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MAOA uVNTR

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https://www.readbyqxmd.com/read/27752275/regional-cortical-thinning-of-the-orbitofrontal-cortex-in-medication-na%C3%A3-ve-female-patients-with-major-depressive-disorder-is-not-associated-with-maoa-uvntr-polymorphism
#1
Eunsoo Won, Sunyoung Choi, June Kang, Min-Soo Lee, Byung-Joo Ham
BACKGROUND: Orbitofrontal cortex alterations have been suggested to underlie the impaired mood regulation in depression. MAOA-uVNTR (monoamine oxidase A-upstream variable number of tandem repeats) polymorphism has been reported to be associated with major depressive disorder by various studies. The influence of MAOA-uVNTR genotype on function and structure of the orbitofrontal cortex has previously been reported. In this study, we investigated the difference in orbitofrontal cortex thickness between medication-naïve female patients with major depressive disorder and healthy controls, and the influence of MAOA-uVNTR genotype on orbitofrontal cortex thickness in depression...
2016: Annals of General Psychiatry
https://www.readbyqxmd.com/read/27112218/platelet-monoamine-oxidase-type-b-maob-intron-13-and-maoa-uvntr-polymorphism-and-symptoms-of-post-traumatic-stress-disorder
#2
Dubravka Svob Strac, Zrnka Kovacic Petrovic, Matea Nikolac Perkovic, Danica Umolac, Gordana Nedic Erjavec, Nela Pivac
Post-traumatic stress disorder (PTSD), a disorder that develops following exposure to traumatic experience(s), is frequently associated with agitation, aggressive behavior and psychotic symptoms. Monoamine oxidase (MAO) degrades different biogenic amines and regulates mood, emotions and behavior, and has a role in the pathophysiology of various neuropsychiatric disorders. The aim of the study was to investigate the association between different symptoms occurring in PTSD [PTSD symptom severity assessed by the Clinician Administered PTSD Scale (CAPS), agitation and selected psychotic symptoms assessed by the Positive and Negative Syndrome Scale (PANSS)] and platelet MAO-B activity and/or genetic variants of MAOB rs1799836 and MAOA-uVNTR polymorphisms in 249 Croatian male veterans with PTSD...
July 2016: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/26851573/monoamine-oxidase-and-agitation-in-psychiatric-patients
#3
Matea Nikolac Perkovic, Dubravka Svob Strac, Gordana Nedic Erjavec, Suzana Uzun, Josip Podobnik, Oliver Kozumplik, Suzana Vlatkovic, Nela Pivac
Subjects with schizophrenia or conduct disorder display a lifelong pattern of antisocial, aggressive and violent behavior and agitation. Monoamine oxidase (MAO) is an enzyme involved in the degradation of various monoamine neurotransmitters and neuromodulators and therefore has a role in various psychiatric and neurodegenerative disorders and pathological behaviors. Platelet MAO-B activity has been associated with psychopathy- and aggression-related personality traits, while variants of the MAOA and MAOB genes have been associated with diverse clinical phenotypes, including aggressiveness, antisocial problems and violent delinquency...
August 1, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/26557993/no-association-of-bdnf-comt-maoa-slc6a3-and-slc6a4-genes-and-depressive-symptoms-in-a-sample-of-healthy-colombian-subjects
#4
Yeimy González-Giraldo, Andrés Camargo, Sandra López-León, Diego A Forero
Background. Major depressive disorder (MDD) is the second cause of years lived with disability around the world. A large number of studies have been carried out to identify genetic risk factors for MDD and related endophenotypes, mainly in populations of European and Asian descent, with conflicting results. The main aim of the current study was to analyze the possible association of five candidate genes and depressive symptoms in a Colombian sample of healthy subjects. Methods and Materials. The Spanish adaptation of the Hospital Anxiety and Depression Scale (HADS) was applied to one hundred eighty-eight healthy Colombian subjects...
2015: Depression Research and Treatment
https://www.readbyqxmd.com/read/26086709/correction-samochowiec-a-et-al-monoamine-oxidase-a-promoter-variable-number-of-tandem-repeats-maoa-uvntr-in-alcoholics-according-to-lesch-typology-int-j-environ-res-public-health-2015-12-3317-3326
#5
Agnieszka Samochowiec, Magdalena Chęć, Edyta Kopaczewska, Jerzy Samochowiec, Otto Lesch, Elżbieta Grochans, Andrzej Jasiewicz, Przemyslaw Bienkowski, Łukasz Kołodziej, Anna Grzywacz
No abstract text is available yet for this article.
June 2015: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/25809512/monoamine-oxidase-a-promoter-variable-number-of-tandem-repeats-maoa-uvntr-in-alcoholics-according-to-lesch-typology
#6
Agnieszka Samochowiec, Magdalena Chęć, Edyta Kopaczewska, Jerzy Samochowiec, Otto Lesch, Elżbieta Grochans, Andrzej Jasiewicz, Przemyslaw Bienkowski, Kołodziej Łukasz, Anna Grzywacz
BACKGROUND: The aim of this study was to examine the association between the MAOA-uVNTR gene polymorphism in a homogeneous subgroups of patients with alcohol dependence categorized according to Lesch's typology. METHODS: DNA was provided from alcohol dependent (AD) patients (n=370) and healthy control subjects (n=168) all of Polish descent. The history of alcoholism was obtained using the Polish version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA)...
March 2015: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/25794322/-association-between-the-maoa-uvntr-polymorphism-and-antisocial-personality-traits-in-alcoholic-men
#7
C Laqua, P Zill, G Koller, U Preuss, M Soyka
AIMS: We have analysed the MAOA-uVNTR polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. The first aim was to examine the association between the MAOA genotype and the alcoholic phenotype. In the second part of the paper we have analysed the association of the MAOA genotype with impulsive and aggressive behaviour. Genotypes with 3 or 5-repeat alleles (MAOA-L-genotype) were reported to be associated with impulsive and aggressive traits. METHODS: The MAOA genotype was determined in 371 male alcohol-dependent subjects and 236 male controls all of German descent...
March 2015: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/25747527/association-study-of-monoamine-oxidase-a-gene-promoter-polymorphism-maoa-uvntr-with-self-reported-anxiety-and-other-psychopathological-symptoms-in-a-community-sample-of-early-adolescents
#8
Núria Voltas, Estefania Aparicio, Victoria Arija, Josefa Canals
The polymorphism upstream of the gene for monoamine oxidase A (MAOA-uVNTR) is reported to be an important enzyme involved in human physiology and behavior. With a sample of 228 early-adolescents from a community sample (143 girls) and adjusting for environmental variables, we examined the influence of MAOA-uVNTR alleles on the scores obtained in the Screen for Childhood Anxiety and Related Emotional Disorders and in the Child Symptom Inventory-4. Our results showed that girls with the high-activity MAOA allele had higher scores for generalized and total anxiety than their low-activity peers, whereas boys with the low-activity allele had higher social phobia scores than boys with the high-activity allele...
April 2015: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/25660313/meta-analysis-of-six-genes-bdnf-drd1-drd3-drd4-grin2b-and-maoa-involved-in-neuroplasticity-and-the-risk-for-alcohol-dependence
#9
Diego A Forero, Sandra López-León, Hyoung Doo Shin, Byung Lae Park, Dai-Jin Kim
BACKGROUND: Alcohol-related problems have a large impact on human health, accounting for around 4% of deaths and 4.5% of disability-adjusted life-years around the world. Genetic factors could explain a significant fraction of the risk for alcohol dependence (AD). Recent meta-analyses have found significant pooled odds ratios (ORs) for variants in the ADH1B, ADH1C, DRD2 and HTR2A genes. METHODS: In the present study, we carried out a meta-analysis of common variants in 6 candidate genes involved in neurotransmission and neuroplasticity: BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA...
April 1, 2015: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/25522433/genotypes-do-not-confer-risk-for-delinquency-but-rather-alter-susceptibility-to-positive-and-negative-environmental-factors-gene-environmentinteractions-of-bdnf-val66met-5-httlpr-and-maoa-uvntr-corrected
#10
Kent W Nilsson, Erika Comasco, Sheilagh Hodgins, Lars Oreland, Cecilia Åslund
BACKGROUND: Previous evidence of gene-by-environment interactions associated with emotional and behavioral disorders is contradictory. Differences in findings may result from variation in valence and dose of the environmental factor, and/or failure to take account of gene-by-gene interactions. The present study investigated interactions between the brain-derived neurotrophic factor gene (BDNF Val66Met), the serotonin transporter gene-linked polymorphic region (5-HTTLPR), the monoamine oxidase A (MAOA-uVNTR) polymorphisms, family conflict, sexual abuse, the quality of the child-parent relationship, and teenage delinquency...
March 2015: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/25199967/identifying-the-interaction-of-maternal-sensitivity-and-two-serotonin-related-gene-polymorphisms-on-infant-self-regulation
#11
Minghao Zhang, Xinyin Chen, Huihua Deng, Zuhong Lu
During infancy, orienting and gaze aversion serve as major self-regulatory mechanisms and play an important role in the development of deliberate self-regulation and control. The present study examined the interaction of intrinsic factors (MAOA-uVNTR and 5-HTTLPR gene polymorphisms) and extrinsic factors (maternal sensitivity) on early infant self-regulatory behavior. We assessed 5-HTTLPR (ss+sl versus ll) and MAOA-uVNTR (3 and 4 among boys, and 3/3, 3/4, and 4/4 among girls) polymorphisms, determined maternal sensitivity during mother-child free play, and coded infant self-regulatory behavior (i...
November 2014: Infant Behavior & Development
https://www.readbyqxmd.com/read/25142096/mitigating-aggressiveness-through-education-the-monoamine-oxidase-a-genotype-and-mental-health-in-general-population
#12
Evelyn Kiive, Kariina Laas, Kirsti Akkermann, Erika Comasco, Lars Oreland, Toomas Veidebaum, Jaanus Harro
OBJECTIVE: Monoamine oxidase A (MAOA) gene promoter region includes a variable number of tandem repeat (VNTR) associated with antisocial behaviour in adverse environment. We have examined the effect of the MAOA-uVNTR on mental health and academic success by using a population representative sample and a longitudinal design. METHODS: The data of the older cohort (n = 593, aged 15 years at the original sampling) of the longitudinal Estonian Children Personality, Behaviour and Health Study (ECPBHS) were used...
February 2014: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/25082653/association-of-low-activity-maoa-allelic-variants-with-violent-crime-in-incarcerated-offenders
#13
Dean A Stetler, Chad Davis, Kathryn Leavitt, Ilana Schriger, Katie Benson, Samir Bhakta, Lam Chee Wang, Cynthia Oben, Matthew Watters, Tara Haghnegahdar, Marco Bortolato
The main enzyme for serotonin degradation, monoamine oxidase (MAO) A, has recently emerged as a key biological factor in the predisposition to impulsive aggression. Male carriers of low-activity variants of the main functional polymorphism of the MAOA gene (MAOA-uVNTR) have been shown to exhibit a greater proclivity to engage in violent acts. Thus, we hypothesized that low-activity MAOA-uVNTR alleles may be associated with a higher risk for criminal violence among male offenders. To test this possibility, we analyzed the MAOA-uVNTR variants of violent (n = 49) and non-violent (n = 40) male Caucasian and African-American convicts in a correctional facility...
November 2014: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/25052486/self-regulatory-failure-and-the-perpetration-of-adolescent-dating-violence-examining-an-alcohol-use-by-gene-explanation
#14
Vangie A Foshee, Thad S Benefield, Samantha Puvanesarajah, Heath Luz McNaughton Reyes, Brett C Haberstick, Andrew Smolen, Susan T Ennett, Chirayath Suchindran
Studies report that alcohol use is related to partner violence, but for many, alcohol use does not culminate in violence against partners. Guided by a self-regulatory failure framework, we predicted that alcohol use would be more strongly associated with dating violence perpetration among adolescents with genotypes linked to impulsivity and emotional reactivity. The hypothesis was tested using random coefficient modeling of data from a multi-wave longitudinal study spanning grades 8-12 (ages 13-18) (n = 1,475)...
March 2015: Aggressive Behavior
https://www.readbyqxmd.com/read/24983833/monoamine-oxidase-a-genotype-childhood-adversity-and-criminal-behavior-in-an-incarcerated-sample
#15
Todd A Armstrong, Brian B Boutwell, Shahida Flores, Mary Symonds, Shawn Keller, David A Gangitano
BACKGROUND: A number of studies have found a functional variable number tandem repeat polymorphism in the upstream regulatory region of the monoamine oxidase A gene (MAOA-uVNTR) interacts with childhood adversity to increase risk for antisocial behavior. Several studies have also reported null findings. METHODS: Here, we examine the association between MAOA-uVNTR genotype, childhood adversity, and criminal activity in a sample of 99 male volunteers who were incarcerated in a large city jail in the Southern United States...
August 2014: Psychiatric Genetics
https://www.readbyqxmd.com/read/24902785/candidate-genes-for-aggression-and-antisocial-behavior-a-meta-analysis-of-association-studies-of-the-5httlpr-and-maoa-uvntr
#16
Courtney A Ficks, Irwin D Waldman
Variation in central serotonin levels due to genetic mutations or experimental modifications has been associated with the manifestation of aggression in humans and animals. Many studies have examined whether common variants in serotonergic genes are implicated in aggressive or antisocial behaviors (ASB) in human samples. The two most commonly studied polymorphisms have been the serotonin transporter linked polymorphic region of the serotonin transporter gene (5HTTLPR) and the 30 base pair variable number of tandem repeats of the monoamine oxidase A gene (MAOA-uVNTR)...
September 2014: Behavior Genetics
https://www.readbyqxmd.com/read/24764243/molecular-genetics-and-antisocial-behavior-where-do-we-stand
#17
REVIEW
Caterina Iofrida, Sara Palumbo, Silvia Pellegrini
Over the last two decades, it has become increasingly evident that control of aggressive behavior is modulated by the individual genetic profile as well. Several candidate genes have been proposed to play a role in the risk to develop antisocial behavior, and distinct brain imaging studies have shown that specific cortical areas may be functionally and/or structurally impaired in impulsive violent subjects on the basis of their genotypes. In this paper, we review the findings regarding four polymorphisms-MAOA (Monoamine oxidase A) uVNTR, SLC6A4 (solute carrier family 6 (neurotransmitter transporter), member 4) 5HTTLPR, COMT (Catechol-O-methyltransferase) Val158Met and DRD4 (dopamine D4 receptor) VNTR 1-11-that all have been found to be associated with an increased vulnerability for antisocial and impulsive behavior in response to aversive environmental conditions...
November 2014: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/24494688/the-upstream-variable-number-tandem-repeat-polymorphism-of-the-monoamine-oxidase-type-a-gene-influences-trigeminal-pain-related-evoked-responses
#18
Cherubino Di Lorenzo, Andrea Daverio, Patrizio Pasqualetti, Gianluca Coppola, Ioannis Giannoudas, Ylenia Barone, Gaetano S Grieco, Cinzia Niolu, Esterina Pascale, Filippo M Santorelli, Ferdinando Nicoletti, Francesco Pierelli, Alberto Siracusano, Stefano Seri, Giorgio Di Lorenzo
Monoamines have an important role in neural plasticity, a key factor in cortical pain processing that promotes changes in neuronal network connectivity. Monoamine oxidase type A (MAOA) is an enzyme that, due to its modulating role in monoaminergic activity, could play a role in cortical pain processing. The X-linked MAOA gene is characterized by an allelic variant of length, the MAOA upstream Variable Number Tandem Repeat (MAOA-uVNTR) region polymorphism. Two allelic variants of this gene are known, the high-activity MAOA (HAM) and low-activity MAOA (LAM)...
February 2014: European Journal of Neuroscience
https://www.readbyqxmd.com/read/24453887/genetic-variants-of-neurotransmitter-related-genes-and-mirnas-in-egyptian-autistic-patients
#19
Ahmed M Salem, Samira Ismail, Waheba A Zarouk, Olwya Abdul Baky, Ahmed A Sayed, Sawsan Abd El-Hamid, Sohair Salem
Autism is a neurodevelopmental disorder with indisputable evidence for a genetic component. This work studied the association of autism with genetic variations in neurotransmitter-related genes, including MAOA uVNTR, MAOB rs1799836, and DRD2 TaqI A in 53 autistic patients and 30 healthy individuals. The study also analyzed sequence variations of miR-431 and miR-21. MAOA uVNTR was genotyped by PCR, MAOB and DRD2 polymorphisms were analyzed by PCR-based RFLP, and miR-431 and miR-21 were sequenced. Low expressing allele of MAOA uVNTR was frequently higher in female patients compared to that in controls (OR = 2...
2013: TheScientificWorldJournal
https://www.readbyqxmd.com/read/24443391/investigation-of-association-of-serotonin-transporter-and-monoamine-oxidase-a-genes-with-alzheimer-s-disease-and-depression-in-the-vita-study-cohort-a-90-month-longitudinal-study
#20
Claus-Jürgen Scholz, Susanne Jungwirth, Walter Danielczyk, Heike Weber, Ildiko Wichart, Karl Heinz Tragl, Peter Fischer, Peter Riederer, Jürgen Deckert, Edna Grünblatt
Alzheimer's disease (AD) and depression (DE) are common psychiatric disorders strongly intertwined with one another. Nevertheless, etiology and early diagnosis of the disorders are still elusive. Several genetic variations have been suggested to associate with AD and DE, particularly in genes involved in the serotonergic system such as the serotonin transporter (SERT/SLC6A4), responsible for the removal from the synaptic cleft, and the monoamine-oxidase-A (MAOA), responsible for the presynaptic degradation of serotonin...
March 2014: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
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