#21
RANDOMIZED CONTROLLED TRIAL
Tingting Liu, Xinling Liu, Rong Wan
BACKGROUND: Postoperative delirium (POD) and neurological dysfunction are very common following cardiac surgery and deteriorate the patient's prognosis and the outcome of surgical procedures. A clinically effective management strategy or drug is not yet available for POD. Additionally, it is unknown whether remote ischemic preconditioning (RIPC) has neuroprotective and anti-delirium benefits in patients who undergo cardiac surgery. METHODS: This study examined whether RIPC can improve POD and neurological function in cardiac surgery patients...
August 31, 2023: Heart Surgery Forum
#22
JOURNAL ARTICLE
Changping Jiao, Cui Liu, Zhenhua Yang, Chunfeng Jin, Xi Chen, Jujun Xue, Ge Zhang, Chengli Pan, Jianrong Jia, Xiaojun Hou
To assess the effectiveness and molecular mechanisms of mild hypothermia and remote ischemic postconditioning (RIPC) in patients with acute ischemic stroke (AIS) who have undergone thrombolysis therapy. A total of 58 AIS patients who received recombinant tissue plasmin activator (rt-PA) intravenous thrombolysis were included in this prospective study. Participants were randomly allocated to the experimental group (rt-PA intravenous thrombolysis plus mild hypothermic ice cap plus remote ischemic brain protection, n = 30) and the control group (rt-PA intravenous thrombolysis plus 0...
September 4, 2023: Therapeutic Hypothermia and Temperature Management
#23
JOURNAL ARTICLE
Tuomas Anttila, Johanna Herajärvi, Henna Laaksonen, Caius Mustonen, Hannu-Pekka Honkanen, Elitsa Y Dimova, Jarkko Piuhola, Peppi Koivunen, Tatu Juvonen, Vesa Anttila
Objectives. Remote ischemic preconditioning (RIPC) mitigates acute myocardial infarction (AMI). We hypothesized that RIPC reduces the size and severity of AMI and explored molecular mechanisms behind this phenomenon. Design. In two series of experiments, piglets underwent 60 min of the circumflex coronary artery occlusion, resulting in AMI. Piglets were randomly assigned into the RIPC groups ( n = 7 + 7) and the control groups ( n = 7 + 7). The RIPC groups underwent four 5-min hind limb ischemia-reperfusion cycles before AMI...
December 2023: Scandinavian Cardiovascular Journal: SCJ
#24
RANDOMIZED CONTROLLED TRIAL
Zhen-Zhou Zhao, En Li, Xue-Jie Li, Quan Guo, Qing-Bo Shi, Mu-Wei Li
This study aimed to determine the effect of short-term remote ischemic preconditioning (RIPC) on coronary blood flow and microcirculation function using the quantitative flow ratio (QFR) and index of microcirculatory resistance (IMR). We randomly divided 129 patients undergoing coronary angiography (CAG) into RIPC and control groups. Following the first CAG, we randomly divided the patients further into the unilateral upper limb and lower limb groups for four cycles of ischemia/reperfusion circulation; subsequently, we performed the second CAG...
August 17, 2023: BMC Cardiovascular Disorders
#25
JOURNAL ARTICLE
Jana Končekova, Klaudia Kotorova, Miroslav Gottlieb, Martin Bona, Petra Bonova
Remote ischaemic conditioning (RIC) becomes an attractive strategy for the endogenous stimulation of mechanisms protecting neurons against ischaemia. Although the processes underlying the RIC are not clearly understood, the homeostasis of glutamate seems to play an important role. The present study is focused on the investigation of the brain to blood efflux of glutamate in a condition mimicking ischaemia-mediated excitotoxicity and remote ischaemic preconditioning (RIPC). The animals were pre-treated with a hind-limb tourniquet one hour before the intraventricular administration of glutamate and its release was monitored as the concentration of glutamate/glutathione in blood and liquor for up to 1 h...
August 2, 2023: Neurochemical Research
#26
JOURNAL ARTICLE
Asmaa A Khalifa, Mennatallah A Ali, Nahed H Elsokkary, Samar S Elblehi, Mahmoud M El-Mas
AIMS: Skeletal muscle ischemia and reperfusion (S-I/R) injury is relieved by interventions like remote ischemic preconditioning (RIPC). Here, we tested the hypothesis that simultaneous exposure to a minimal dose of erythropoietin (EPO) boosts the protection conferred by RIPC against S-I/R injury and concomitant mitochondrial oxidative and apoptotic defects. MAIN METHODS: S-I/R injury was induced in rats by 3-h right hindlimb ischemia followed by 3-h of reperfusion, whereas RIPC involved 3 brief consecutive I/R cycles of the contralateral hindlimb...
July 27, 2023: Life Sciences
#27
JOURNAL ARTICLE
Karl Kuusik, Teele Kasepalu, Mihkel Zilmer, Jaan Eha, Kaido Paapstel, Kalle Kilk, Aune Rehema, Jaak Kals
Remote ischemic preconditioning (RIPC) has demonstrated protective effects in patients with lower extremity arterial disease (LEAD) undergoing digital subtraction angiography (DSA) and/or percutaneous transluminal angioplasty (PTA). This study aimed to investigate the impact of RIPC on the metabolomical profile of LEAD patients undergoing these procedures and to elucidate its potential underlying mechanisms. A total of 100 LEAD patients were enrolled and randomly assigned to either the RIPC group (n = 46) or the sham group (n = 54)...
July 18, 2023: Metabolites
#28
JOURNAL ARTICLE
Yiu-Fai Cheung, Vivian Wing-Yi Li, Edwina Kam-Fung So, Frankie Wai-Tsoi Cheng, Jeffery Ping-Wa Yau, Sau-Ying Chiu, Wilfred Hing-Sang Wong, Daniel Ka-Leung Cheuk
BACKGROUND: Anthracycline cardiotoxicity is a concern in survivors of childhood cancers. Recent evidence suggests that remote ischemic conditioning (RIC) may offer myocardial protection. OBJECTIVES: This randomized sham-controlled single-blind study tested the hypothesis that RIC may reduce myocardial injury in pediatric cancer patients receiving anthracycline chemotherapy. METHODS: We performed a phase 2 sham-controlled single-blind randomized controlled trial to determine the impact of RIC on myocardial injury in pediatric cancer patients receiving anthracycline-based chemotherapy...
June 2023: JACC CardioOncology
#29
JOURNAL ARTICLE
Fan Wang, Chu-Jun Liang, Jian-Kun Shi, Qing-Shan Huang, Bizo Mailoga Nassirou, Xi Wang, San-Qing Jin, Yang Zhao
INTRODUCTION: Myocardial injury after non-cardiac surgery (MINS) caused by an ischaemic mechanism is common and is associated with adverse short-term and long-term prognoses. However, MINS is a recent concept, and few studies have prospectively used it as a primary outcome. Remote ischaemic preconditioning (RIPC) is a non-invasive procedure that induces innate cardioprotection and may reduce MINS. METHODS AND ANALYSIS: This is a multicentre, randomised, sham-controlled, observer-blinded trial...
June 23, 2023: BMJ Open
#30
JOURNAL ARTICLE
Rahul Kota, Marco Gemelli, Arnaldo Dimagli, Saadeh Suleiman, Marco Moscarelli, Tim Dong, Gianni D Angelini, Daniel P Fudulu
INTRODUCTION: Postoperative Atrial Fibrillation (POAF) is a common complication of cardiac surgery, associated with increased mortality, stroke risk, cardiac failure and prolonged hospital stay. Our study aimed to assess the patterns of release of systemic cytokines in patients with and without POAF. METHODS: A post-hoc analysis of the Remote Ischemic Preconditioning (RIPC) trial, including 121 patients (93 males and 28 females, mean age of 68 years old) who underwent isolated coronary artery bypass grafting (CABG) and aortic valve replacement (AVR)...
2023: Frontiers in Surgery
#31
JOURNAL ARTICLE
Farkašová Farkašová, L Kindernay, M Ferko, T Rajtík, A Szobi, T Ravingerová
Remote ischemic preconditioning (RIPC) represents one of the forms of innate cardioprotection. While being effective in animal models, its application in humans has not been always beneficial, which might be attributed to the presence of various comorbidities, such as hypertension, or being related to the confounding factors, such as patients' sex and age. RIPC has been shown to mediate its cardioprotective effects through the activation of Reperfusion Injury Salvage Kinase (RISK) pathway in healthy animals, however, scarce evidence supports this effect of RIPC in the hearts of spontaneously hypertensive (SHR) rats, in particular, in relationship with aging...
June 9, 2023: Physiological Research
#32
JOURNAL ARTICLE
Lawrence P Cahalin, Magno F Formiga, Johnny Owens, Brian M Osman
Purpose: To determine the effects of remote ischemic preconditioning (RIPC) on pulmonary gas exchange in people undergoing pulmonary surgery and discuss a potential role of RIPC in COVID-19. Method: A search for studies examining the effects of RIPC after pulmonary surgery was performed. RevMan was used for statistical analyses examining measures of A-ado2 , Pao2 /Fio2 , respiratory index (RI), a/A ratio and Paco2 obtained earlier after surgery (i.e., 6-8 hours) and later after surgery (i.e., 18-24 hours). Results: Four trials were included ( N = 369 participants)...
2023: Physiotherapy Canada. Physiothérapie Canada
#33
JOURNAL ARTICLE
Kenji Omae, Tsunenori Kondo, Shingo Fukuma, Tatsuyoshi Ikenoue, Daisuke Toki, Hidekazu Tachibana, Toshihide Horiuchi, Ryo Ishiyama, Maki Yoshino, Yudai Ishiyama, Shunichi Fukuhara, Kazunari Tanabe, Toshio Takagi
We aimed to evaluate the renoprotective effects of remote ischemic preconditioning (RIPC) in patients undergoing robot-assisted laparoscopic partial nephrectomy (RAPN). Data from 59 patients with solitary renal tumors who underwent RAPN with RIPC comprising three cycles of 5-min inflation to 200 mmHg of a blood pressure cuff applied to one lower limb followed by 5-min reperfusion by cuff deflation, from 2018 to 2020 were analyzed. Patients who underwent RAPN for solitary renal tumors without RIPC between 2018 and 2020 were selected as controls...
May 22, 2023: Journal of Robotic Surgery
#34
JOURNAL ARTICLE
Haizhao Zhang, Shuang Li, Yu Jin
PURPOSE: Remote ischemic preconditioning (RIPC) confers cardioprotection against ischemia reperfusion (IR) injury. However, the precise mechanisms involved in RIPC-induced cardioprotection are not fully explored. The present study was aimed to identify the role of melatonin in RIPC-induced late cardioprotective effects in rats and to explore the role of H2S, TNF-α and mitoKATP in melatonin-mediated effects in RIPC. METHODS: Wistar rats were subjected to RIPC in which hind limb was subjected to four alternate cycles of ischemia and reperfusion of 5 min duration by using a neonatal blood pressure cuff...
2023: Acta Cirúrgica Brasileira
#35
JOURNAL ARTICLE
Yu Wu, Simin Zhou, Yaling Li, Pei Huang, Zhifeng Zhong, Huaping Dong, Huaijun Tian, Shuai Jiang, Jiaxin Xie, Peng Li
OBJECTIVE: The high-altitude hypoxia environment will cause poor acclimatization in a portion of the population. Remote ischemic preconditioning(RIPC)has been demonstrated to prevent cardiovascular and cerebrovascular diseases under ischemic or hypoxic conditions. However, its role in improving acclimatization and preventing acute mountain sickness (AMS) at high altitude has been undetermined. This study aims to estimate the effect of RIPC on acclimatization of individuals exposed to high altitude...
April 15, 2023: Travel Medicine and Infectious Disease
#36
JOURNAL ARTICLE
Liang Zhao, Zhuo Chen, Jing Cheng, Baojun Chen, Yong Liu
BACKGROUND: Acute lung injury (ALI) may result in severe systemic inflammation and is life-threatening. Remote inflammatory preconditioning (RIPC) has been confirmed to have an endogenous protective effect against ALI. Budesonide (BS) is a potent corticosteroid typically administered through nebulization that reduces inflammation in the lungs. We speculate that the combined use of RIPC and nebulized BS has a stronger protective effect on ALI. METHODS: 48 Sprague-Dawley male rats were used for the experiments...
April 13, 2023: Pulmonary Pharmacology & Therapeutics
#37
REVIEW
Aikaterini Papadopoulou, Matthew Dickinson, Theophilus L Samuels, Christian Heiss, Lui Forni, Ben Creagh-Brown
BACKGROUND: Remote ischaemic preconditioning (RIPC) has been investigated as a simple intervention to potentially mitigate the ischaemic effect of the surgical insult and reduce postoperative morbidity. This review systematically evaluates the effect of RIPC on morbidity, including duration of hospital stay and parameters reflective of cardiac, renal, respiratory, and hepatic dysfunction following non-cardiac non-vascular (NCNV) surgery. METHODS: The electronic databases PubMed, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from their inception date to November 2021...
April 10, 2023: Perioperative Medicine
#38
JOURNAL ARTICLE
Yang Du, Rui Qiu, Lei Chen, Yuewen Chen, Zhifeng Zhong, Peng Li, Fangcheng Fan, Yong Cheng
BACKGROUND: Remote ischemic preconditioning (RIPC) refers to a brief episode of exposure to potential adverse stimulation and prevents injury during subsequent exposure. RIPC has been shown to increase tolerance to ischemic injury and improve cerebral perfusion status. Exosomes have a variety of activities, such as remodeling the extracellular matrix and transmitting signals to other cells. This study aimed to investigate the potential molecular mechanism of RIPC-mediated neuroprotection...
April 3, 2023: Journal of Translational Medicine
#39
JOURNAL ARTICLE
Kirsten L Wahlstrøm, Hannah F Hansen, Madeline Kvist, Jakob Burcharth, Jens Lykkesfeldt, Ismail Gögenur, Sarah Ekeloef
Endothelial dysfunction result from inflammation and excessive production of reactive oxygen species as part of the surgical stress response. Remote ischemic preconditioning (RIPC) potentially exerts anti-oxidative and anti-inflammatory properties, which might stabilise the endothelial function after non-cardiac surgery. This was a single centre randomised clinical trial including 60 patients undergoing sub-acute laparoscopic cholecystectomy due to acute cholecystitis. Patients were randomised to RIPC or control...
March 16, 2023: Cells
#40
JOURNAL ARTICLE
Mengnan Han, Xiaoqian Wu, Jianli Li, Shuang Han, Junfang Rong
PURPOSE: We hypothesized that remote ischemic preconditioning (RIPC) could improve postoperative cognitive dysfunction (POCD) in elderly patients following laparoscopic cholecystectomy (LC). PATIENTS AND METHODS: Eighty-eight patients were randomly assigned to either the control or the RIPC group. The RIPC was applied on the right upper limb using a blood pressure cuff inflating 200 mmHg, consisting of 3 cycles of 5 min ischemia and 5 min reperfusion. Serum concentrations of Neuron-specific Enolase (NSE) and Brain-Derived Neurotrophic Factor (BDNF) were collected at one-day preoperative (T0), at the end of the operation (T4) and one-day postoperative (T5)...
2023: International Journal of General Medicine
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