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https://www.readbyqxmd.com/read/29130941/remote-ischemia-preconditioning-attenuates-blood-spinal-cord-barrier-breakdown-in-rats-undergoing-spinal-cord-ischemia-reperfusion-injury-associated-with-activation-and-upregulation-of-cb1-and-cb2-receptors
#1
Na Jing, Bo Fang, Zhi-Lin Wang, Hong Ma
BACKGROUND/AIMS: Remote ischemic preconditioning (RIPC) has protective effects on spinal cord ischemia reperfusion (I/R) injury, but the potential mechanisms remain unclear. In our study, the effects and underlying mechanisms of RIPC on blood-spinal cord barrier (BSCB) breakdown following I/R injury were investigated. METHODS: animals underwent intraperitoneal administration with cannabinoid-1 (CB1) receptor antagonist AM251, cannabinoid-2 (CB2) receptor antagonist AM630 or vehicle 15 minutes before three 3-minute occlusion-reperfusion cycles on the right femoral artery or a sham operation...
October 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29094209/comparison-of-the-protective-effects-of-direct-ischemic-preconditioning-and-remote-ischemic-preconditioning-in-a-rabbit-model-of-transient-spinal-cord-ischemia
#2
Takehiko Fukui, Kazuyoshi Ishida, Yoichi Mizukami, Kiyotaka Shiramoto, Hidenori Harada, Atsuo Yamashita, Satoshi Yamashita, Mishiya Matsumoto
INTRODUCTION: This study aimed to determine the relative potency of direct ischemic preconditioning (DIPC) and remote ischemic preconditioning (RIPC) for protection against ischemic spinal cord injury in rabbits and to explore the mechanisms involved. METHODS: In experiment 1, we compared the neurological and histopathological outcomes of DIPC, kidney RIPC, and limb RIPC. The DIPC and kidney RIPC groups received two cycles of 5-min occlusion/15-min reperfusion of the abdominal aorta and left renal artery, respectively...
November 1, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/29083941/modulation-of-remote-ischemic-preconditioning-by-proinflammatory-cytokines-in-renal-transplant-recipients
#3
Homero Zapata-Chavira, Marco Hernández-Guedea, Julio César Jiménez-Pérez, Edelmiro Pérez-Rodríguez, Linda Muñoz-Espinosa, Gerardo Muñoz-Maldonado, Paula Cordero-Pérez
AIM: Remote ischemic preconditioning (RIPC) has been used as a strategy to reduce acute renal injury and ischemia-reperfusion injury (IRI) in renal transplantation (RT) with controversial results. OBJECTIVE: To determine if RIPC modifies IRI in cadaveric RT recipients through inflammatory mediators and graft function. METHODS: Twenty-nine RT recipients were studied, 12 in the control group (CG) and 17 in the RIPC group. RIPC which was performed on donors using a pneumatic tourniquet placed on both thighs for 10 min followed by the determination of IL-1, IL-6, TNF-α, VEGF, and ICAM-1, and hematological and biochemical parameters in different phases of RT...
October 30, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29077609/impact-of-anesthetic-regimen-on-remote-ischemic-preconditioning-in-the-rat-heart-in-vivo
#4
Friederike Behmenburg, Patrick van Caster, Sebastian Bunte, Timo Brandenburger, André Heinen, Markus W Hollmann, Ragnar Huhn
Remote ischemic preconditioning (RIPC) seems to be a promising cardioprotective strategy with contradictive clinical data suggesting the anesthetic regimen influencing the favorable impact of RIPC. This study aimed to investigate whether cardio protection by RIPC is abolished by anesthetic regimens. Male Wistar rats were randomized to 6 groups. Anesthesia was either maintained by pentobarbital (Pento) alone or a combination of sevoflurane (Sevo) and remifentanil or propofol (Prop) and remifentanil in combination with and without RIPC...
October 26, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29063424/assessing-renal-changes-after-remote-ischemic-preconditioning-ripc-of-the-upper-extremity-using-bold-imaging-at-3t
#5
Florian Siedek, Thorsten Persigehl, Roman-Ulrich Mueller, Volker Burst, Thomas Benzing, David Maintz, Stefan Haneder
OBJECTIVE: Acute kidney injury (AKI) is an important risk factor for a number of adverse outcomes including end-stage renal disease and cardiovascular morbidity and mortality. Whilst many clinical situations that can induce AKI are known-e.g. drug toxicity, contrast agent exposure or ischemia during surgery-targeted preventive or therapeutic measures are still lacking. As to renoprotective strategies, remote ischemic preconditioning (RIPC) is one of the most promising novel approaches and has been examined by a number of clinical trials...
October 23, 2017: Magma
https://www.readbyqxmd.com/read/29062582/effect-of-remote-ischemic-preconditioning-on-perioperative-cardiac-events-in-patients-undergoing-elective-percutaneous-coronary-intervention-a-meta-analysis-of-16-randomized-trials
#6
REVIEW
Xiangming Wang, Na Kong, Chuanwei Zhou, Deeraj Mungun, Zakaria Iyan, Yan Guo, Zhijian Yang
BACKGROUND: The main objective of this meta-analysis was to investigate whether remote ischemic preconditioning (RIPC) reduces cardiac and renal events in patients undergoing elective cardiovascular interventions. METHODS AND RESULTS: We systematically searched articles published from 2006 to 2016 in PubMed, EMBASE, Web of Science, Cochrane Library, and Google Scholar. Odds ratios (ORs) with 95% confidence intervals (CIs) were used as the effect index for dichotomous variables...
2017: Cardiology Research and Practice
https://www.readbyqxmd.com/read/29055710/remote-ischemic-preconditioning-in-high-risk-cardiovascular-surgery-patients-a-randomized-controlled-trial
#7
Nicole S Coverdale, Andrew Hamilton, Dimitri Petsikas, R Scott McClure, Paul Malik, Brian Milne, Tarit Saha, David Zelt, Peter Brown, Darrin M Payne
Remote ischemic preconditioning (RIPC) may reduce biomarkers of ischemic injury after cardiovascular surgery. However, it is unclear whether RIPC has a positive impact on clinical outcomes. We performed a blinded, randomized controlled trial to determine if RIPC resulted in fewer adverse clinical outcomes after cardiac or vascular surgery. The intervention consisted of 3 cycles of RIPC on the upper limb for 5 minutes alternated with 5 minutes of rest. A sham intervention was performed on the control group. Patients were recruited who were undergoing (1) high-risk cardiac or vascular surgery or (2) cardiac or vascular surgery and were at high risk of ischemic complications...
September 11, 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29052801/coronary-flow-response-to-remote-ischemic-preconditioning-is-preserved-in-old-cardiac-patients
#8
Elpidio Santillo, Monica Migale, Fabrizio Balestrini, Demetrio Postacchini, Silvia Bustacchini, Fabrizia Lattanzio, Raffaele Antonelli-Incalzi
BACKGROUND: The effect of remote ischemic preconditioning (RIPC) on coronary flow in elderly cardiac patients has not been investigated yet. Thus, we aimed to study the change of coronary flow subsequent to RIPC in old patients with heart diseases and to identify its main correlates. METHODS: Ninety-five elderly patients (aged ≥ 65 years) accessing cardiac rehabilitation ward underwent transthoracic ultrasound evaluation of peak diastolic flow velocity of left anterior descending artery...
October 20, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29033507/syntax-score-of-infarct-related-artery-other-than-the-number-of-coronary-balloon-inflations-and-deflations-as-an-independent-predictor-of-contrast-induced-acute-kidney-injury-in-patients-with-st-segment-elevation-myocardial-infarction
#9
Cheng-Wei Liu, Pen-Chih Liao, Kuo-Chin Chen, Jung-Cheng Hsu, Chung-Ming Tu, Yen-Wen Wu, Ai-Hsien Li, Shin-Rong Ke, Jiunn-Lee Lin
BACKGROUND: Although remote ischemic post-conditioning (RIPC) has been shown to prevent contrast-induced acute kidney injury (CIAKI) in patients with acute coronary syndrome, its efficacy in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. We examined the relationship among balloon inflations and deflations (BID) times, SYNTAX score of infarction-related artery (SI), periprocedural complications, and CIAKI in STEMI patients undergoing primary percutaneous coronary intervention (pPCI)...
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28992285/remote-ischaemic-preconditioning-for-renal-and-cardiac-protection-in-adult-patients-undergoing-cardiac-surgery-with-cardiopulmonary-bypass-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
Giacomo Deferrari, Alice Bonanni, Maurizio Bruschi, Cristiano Alicino, Alessio Signori
Background: The main aim of this systematic review was to assess whether remote ischaemic preconditioning (RIPC) protects kidneys and the heart in cardiac surgery with cardiopulmonary bypass (CPB) and to investigate a possible role of anaesthetic agents. Methods: Randomized clinical trials (RCTs) on the effects of RIPC through limb ischaemia in adult patients undergoing cardiac surgery with CPB were searched (1965-October 2016) in PubMed, Cochrane Library and article reference lists...
July 19, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28988529/effect-of-anesthetics-on-efficiency-of-remote-ischemic-preconditioning
#11
D N Silachev, E A Usatikova, I B Pevzner, L D Zorova, V A Babenko, M V Gulyaev, Yu A Pirogov, E Yu Plotnikov, D B Zorov
Remote ischemic preconditioning of hind limbs (RIPC) is an effective method for preventing brain injury resulting from ischemia. However, in numerous studies RIPC has been used on the background of administered anesthetics, which also could exhibit neuroprotective properties. Therefore, investigation of the signaling pathways triggered by RIPC and the effect of anesthetics is important. In this study, we explored the effect of anesthetics (chloral hydrate and Zoletil) on the ability of RIPC to protect the brain from injury caused by ischemia and reperfusion...
September 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28978919/potential-humoral-mediators-of-remote-ischemic-preconditioning-in-patients-undergoing-surgical-coronary-revascularization
#12
Nilgün Gedik, Eva Kottenberg, Matthias Thielmann, Ulrich H Frey, Heinz Jakob, Jürgen Peters, Gerd Heusch, Petra Kleinbongard
Remote ischemic preconditioning (RIPC) by repeated brief cycles of limb ischemia/reperfusion may reduce myocardial ischemia/reperfusion injury and improve patients' prognosis after elective coronary artery bypass graft (CABG) surgery. The signal transducer and activator of transcription (STAT)5 activation in left ventricular myocardium is associated with RIPC´s cardioprotection. Cytokines and growth hormones typically activate STATs and could therefore act as humoral transfer factors of RIPC´s cardioprotection...
October 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28954945/ischemic-tolerance-of-the-brain-and-spinal-cord-a-review
#13
Masatoshi Yunoki, Takahiro Kanda, Kenta Suzuki, Atsuhito Uneda, Koji Hirashita, Kimihiro Yoshino
Ischemic tolerance is an endogenous neuroprotective phenomenon induced by sublethal ischemia. Ischemic preconditioning (IPC), the first discovered form of ischemic tolerance, is widely seen in many species and in various organs including the brain and the spinal cord. Ischemic tolerance of the spinal cord is less familiar among neurosurgeons, although it has been reported from the viewpoint of preventing ischemic spinal cord injury during aortic surgery. It is important for neurosurgeons to have opportunities to see patients with spinal cord ischemia, and to understand ischemic tolerance of the spinal cord as well as the brain...
September 27, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28951984/remote-ischemic-preconditioning-protects-human-neural-stem-cells-from-oxidative-stress
#14
Ayako Motomura, Mikiko Shimizu, Akira Kato, Kazuya Motomura, Akane Yamamichi, Hiroko Koyama, Fumiharu Ohka, Tomohide Nishikawa, Yusuke Nishimura, Masahito Hara, Tetsuya Fukuda, Yasuhiko Bando, Toshihide Nishimura, Toshihiko Wakabayashi, Atsushi Natsume
In previous clinical trials, we showed that remote ischemic preconditioning (rIPC) reduced myocardial damage in children undergoing treatment for congenital heart defects and postoperative renal failure in patients undergoing abdominal aortic aneurysm surgery. In rabbit experiments, pre-treatment with plasma and plasma dialysate (obtained using 15-kDa cut-off dialysis membrane) from donor rabbits subjected to rIPC similarly protected against cardiac infarction. However, the protective substances containing in rIPC plasma have been unknown...
November 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28932492/kidney-remote-ischemic-preconditioning-as-a-novel-strategy-to-explore-the-accurate-protective-mechanisms-underlying-remote-ischemic-preconditioning
#15
Muobarak J Tuorkey
INTRODUCTION: This study reports a novel strategy for investigating the key factors responsible for the protective effect of remote ischemic preconditioning (RIPC) against renal ischemia-reperfusion (IR) injury, which remains the leading cause of the acute kidney injury that increase the morbidity and mortality in patients with renal impairment. METHODS: The renal blood flow of the right kidneys in kidney remote ischemic preconditioning (KRIPC) group was occluded for 20 min...
March 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28920042/mitochondrial-atp-sensitive-potassium-channels-play-a-role-in-reducing-both-myocardial-infarction-and-reperfusion-arrhythmia-in-remote-ischemic-preconditioned-hearts
#16
Young-Ho Jang, June-Hong Kim, Yong-Cheol Lee
BACKGROUND: Mitochondrial ATP-sensitive potassium (mKATP) channels play a role in reperfusion arrhythmias (RAs) in ischemia-reperfusion (I/R) injury. Evidence suggests that remote ischemic preconditioning (RIPC) reduces RAs, however not much is known on the mechanistic role of mKATP in RIPC. We evaluated whether mKATP channels are associated with reducing arrhythmia and infarct size in RIPC. METHODS: Isolated rat hearts received 30 minutes of regional ischemia followed by 2 hours of reperfusion through the Langendorff perfusion system...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28893433/effects-of-remote-ischemic-preconditioning-in-patients-with-concentric-myocardial-hypertrophy-a-randomized-controlled-trial-with-molecular-insights
#17
Young Song, Jong Wook Song, Sak Lee, Ji-Hae Jun, Young-Lan Kwak, Jae-Kwang Shim
BACKGROUND: Efficacy of remote ischemic preconditioning (RIPC) for cardioprotection in cardiac surgery is controversial. We aimed to evaluate the clinical and molecular effects of RIPC on the concentrically hypertrophied myocardium. METHODS: Seventy-two aortic stenosis patients receiving aortic valve replacement (AVR) under sevoflurane anesthesia were randomly allocated to RIPC (3cycles of 5-min inflation [300mmHg] and deflation on the left arm) or control (deflated cuff placement) group...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28887256/remote-ischemic-preconditioning-decreases-the-magnitude-of-hepatic-ischemia-reperfusion-injury-on-a-swine-model-of-supraceliac-aortic-cross-clamping
#18
G Martikos, A Kapelouzou, M Peroulis, A Paspala, D Athanasiadis, A Maheras, T D Liakakos, K Moulakakis, S Vasdekis, A M Lazaris
BACKGROUND: Temporary hepatic ischemia is inevitable during open aortic surgery when supraceliac clamping is necessary, as in thoracoabdominal or pararenal aneurysms. Remote ischemic preconditioning (RIPC) has been described as a potential protective means against ischemia - reperfusion injury (IRI) in various tissues including the liver. The aim of this experimental study was to detect the effect of RIPC on liver IRI in a model of supraceliac aortic cross-clamping. METHODS: An animal study was performed...
September 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28835448/cyclical-blood-flow-restriction-resistance-exercise-a-potential-parallel-to-remote-ischemic-preconditioning
#19
Justin Daniel Sprick, Caroline A Rickards
Remote ischemic preconditioning (RIPC) is characterized by the cyclical application of limb blood flow restriction and reperfusion, and has been shown to protect vital organs during a subsequent ischemic insult. Blood flow restriction exercise (BFRE) similarly combines bouts of blood flow restriction with low-intensity exercise and thus could potentially emulate the protection demonstrated by RIPC. One concern with BFRE, however, is the potential for an augmented rise in sympathetic outflow, due to greater activation of the exercise pressor reflex...
August 23, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28835447/combining-remote-ischemic-preconditioning-and-aerobic-exercise-a-novel-adaptation-of-blood-flow-restriction-exercise
#20
Justin Daniel Sprick, Caroline A Rickards
Remote ischemic preconditioning (RIPC) can attenuate tissue damage sustained by ischemia-reperfusion injury. Blood flow restriction exercise (BFRE) restricts blood flow to exercising muscles. We implemented a novel approach to BFRE with cyclical bouts of blood flow restriction-reperfusion, reflecting the RIPC model. A concern about BFRE, however, is potential amplification of the exercise pressor reflex, which could be unsafe in at-risk populations. We hypothesized that cyclical BFRE would elicit greater increases in sympathetic outflow and arterial pressure than conventional exercise (CE), performed at the same relative intensity...
August 23, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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