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https://www.readbyqxmd.com/read/28822273/ligand-binding-characterization-of-simulated-%C3%AE-adrenergic-like-octopamine-receptor-in-schistocerca-gregaria-via-progressive-structure-simulation
#1
Hui-Meng Lu, Xiao-Li Lu, Jia-Hui Zhai, Ren-Bin Zhou, Yan-Li Qin, Jing-Di Li, Chen-Yan Zhang, Jian-Yu Shi
It is important to design insecticides having both low drug resistance and less undesirable toxicity for desert locust control. Specific GPCRs of Schistocerca gregaria, especially β-adrenergic-like octopamine receptor (SgOctβR), can be considered as its potential effective insecticide targets. However, either the unavailability of SgOctβR's structure or the inadequate capability of its sequence lead the development of insecticide for Schistocerca gregaria meets its plateau. To relax this difficulty, this paper develops a promising progressive structure simulation from SgOctβR's sequence, to its predicted structure of SgOctβR in vacuum, to its conformation as well as its complex with endogenous ligand octopamine in a solvent-membrane system...
July 27, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28822099/insecticide-toxicity-to-the-borer-neoleucinodes-elegantalis-guen%C3%A3-e-lepidoptera-crambidae-developmental-and-egg-laying-effects
#2
R S Silva, L P Arcanjo, J R S Soares, D O Ferreira, J E Serrão, J C Martins, Á H Costa, M C Picanço
Neoleucinodes elegantalis (Guenée) (Lepidoptera: Crambidae) is one of the major pests of solanaceous plants in South America. It is considered a great threat by the European and Mediterranean Plant Protection Organization due to the serious economic damage that it causes on tomato farms; therefore, controlling this pest is a challenging task in South America. Controlling N. elegantalis at the egg stage is the best way to prevent it from damaging crops; however, thorough studies about the effectiveness of chemicals on the different life stages of this insect pest are lacking...
August 18, 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/28820722/house-structure-is-associated-with-plasmodium-falciparum-infection-in-a-low-transmission-setting-in-southern-zambia
#3
Matthew M Ippolito, Kelly M Searle, Harry Hamapumbu, Timothy M Shields, Jennifer C Stevenson, Philip E Thuma, William J Moss, For The Southern Africa International Center Of Excellence For Malaria Research
House structure may influence the risk of malaria by affecting mosquito entry and indoor resting. Identification of construction features associated with protective benefits could inform vector control approaches, even in low-transmission settings. We examined the association between house structure and malaria prevalence in a cross-sectional analysis of 2,788 children and adults residing in 866 houses in a low-transmission area of Southern Province, Zambia, over the period 2008-2012. Houses were categorized according to wall (brick/cement block or mud/grass) and roof (metal or grass) material...
August 7, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28820587/flupyrimin-a-novel-insecticide-acting-at-the-nicotinic-acetylcholine-receptors
#4
Yasumichi Onozaki, Ryo Horikoshi, Ikuya Ohno, Shigeki Kitsuda, Kathleen A Durkin, Tomonori Suzuki, Chiaki Asahara, Natsuko Hiroki, Rena Komabashiri, Rikako Shimizu, Shogo Furutani, Makoto Ihara, Kazuhiko Matsuda, Masaaki Mitomi, Shinzo Kagabu, Katsuhito Uomoto, Motohiro Tomizawa
A novel chemotype insecticide flupyrimin (FLP) [N-[(E)-1-(6-chloro-3-pyridinylmethyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide], discovered by Meiji Seika Pharma, has unique biological properties including outstanding potency to imidacloprid (IMI)-resistant rice pests together with superior safety toward pollinators. Intriguingly, FLP acts as a nicotinic antagonist in American cockroach neurons and [3H]FLP binds to the multiple high-affinity binding components in house fly nicotinic acetylcholine (ACh) receptor (nAChR) preparation...
August 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28820005/inhibition-of-endocannabinoid-metabolizing-enzymes-in-peripheral-tissues-following-developmental-chlorpyrifos-exposure-in-rats
#5
Robert W Buntyn, Navatha Alugubelly, Rachel L Hybart, Afzaal N Mohammed, Carole A Nail, Greta C Parker, Matthew K Ross, Russell L Carr
Repeated developmental exposure to the organophosphate (OP) insecticide chlorpyrifos (CPF) inhibits brain fatty acid amide hydrolase (FAAH) activity at low levels, whereas at higher levels, it inhibits brain monoacylglycerol lipase (MAGL) activity. FAAH and MAGL hydrolyze the endocannabinoids anandamide (AEA) and 2-arachidonylglycerol (2-AG), respectively. Peripherally, AEA and 2-AG have physiological roles in the regulation of lipid metabolism and immune function, and altering the normal levels of these lipid mediators can negatively affect these processes...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28819819/evaluation-of-the-leaching-potential-of-anthranilamide-insecticides-through-the-soil
#6
Nuria Vela, Gabriel Pérez-Lucas, María J Navarro, Isabel Garrido, José Fenoll, Simón Navarro
The mobility of two relatively new antranilic diamide insecticides, cyanantraniliprole (CY) and cholantraniliprole (CH) in soil was examined, by means of disturbed columns loaded with a typical semiarid Mediterranean soil (Calcaric fluvisol) under laboratory conditions. Both insecticides appeared in leachates, with 52% of CY and 41% of CH of the initial mass added (1 µg g(-1)) present. For CY, 21% and 19% were recovered from the upper and bottom layers of the soil, respectively, while for CH, 33% and 22% were recovered from the upper and bottom layers respectively...
August 17, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28819698/sublethal-effects-of-pyrethroid-and-neonicotinoid-insecticides-on-iphiseiodes-zuluagai-denmark-and-muma-mesostigmata-phytoseiidae
#7
Odimar Zanuzo Zanardi, Gabriela Pavan Bordini, Aline Aparecida Franco, Cynthia Renata Oliveira Jacob, Pedro Takao Yamamoto
The predator mite Iphiseiodes zuluagai Denmark & Muma is an important biological-control agent of mite pests, and it is one of the most common species found in citrus orchards. This study assessed, under laboratory conditions, the toxicity and duration of the harmful effects of five insecticides, the three pyrethroids deltamethrin, esfenvalerate and lambda-cyhalothrin, and the two neonicotinoids imidacloprid and thiamethoxam on I. zuluagai. Furthermore, we estimated the life-table parameters of the predator...
August 17, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28819220/nosema-ceranae-fipronil-and-their-combination-compromise-honey-bee-reproduction-via-changes-in-male-physiology
#8
Guillaume Kairo, David G Biron, Faten Ben Abdelkader, Marc Bonnet, Sylvie Tchamitchian, Marianne Cousin, Claudia Dussaubat, Boris Benoit, André Kretzschmar, Luc P Belzunces, Jean-Luc Brunet
The honey bee is threatened by biological agents and pesticides that can act in combination to induce synergistic effects on its physiology and lifespan. The synergistic effects of a parasite/pesticide combination have been demonstrated on workers and queens, but no studies have been performed on drones despite their essential contribution to colony sustainability by providing semen diversity and quality. The effects of the Nosema ceranae/fipronil combination on the life traits and physiology of mature drones were examined following exposure under semi-field conditions...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818627/cross-sectional-analysis-of-the-association-between-bedtime-and-malaria-exposure-in-the-ouest-and-sud-est-departments-of-haiti
#9
Caroline J Stephenson, Matthew E Rossheim, Cara L Frankenfeld, Jacques Boncy, Bernard O Okech, Michael E von Fricken
INTRODUCTION: The governments of Haiti and the Dominican Republic have a binational agreement to work towards malaria elimination for the island of Hispaniola by the year 2020. Understanding malaria-related knowledge and behaviors can help inform elimination efforts. This study examined the association between social-behavioral factors, like bedtime and bed net ownership, with malaria seroconversion status among people in the Ouest and Sud-Est departments of Haiti. METHODS: In 2013, cross-sectional survey data (n=377) and blood samples were collected from a convenience sample of individuals within community, clinic and school settings...
August 14, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28818077/evaluation-of-piperonyl-butoxide-in-enhancing-the-efficacy-of-pyrethroid-insecticides-against-resistant-anopheles-gambiae-s-l-in-ghana
#10
Samuel K Dadzie, Joseph Chabi, Andy Asafu-Adjaye, Otubea Owusu-Akrofi, Aba Baffoe-Wilmot, Keziah Malm, Constance Bart-Plange, Sylvester Coleman, Maxwell A Appawu, Daniel A Boakye
BACKGROUND: Malaria vector control methods involving the use of pyrethroids remain the strategies being used against malaria vectors in Ghana. These methods include the use of long-lasting insecticidal nets and indoor residual spraying in many areas in Ghana. However, there is evidence that pyrethroid resistance is widespread in many areas in Ghana. Synergists have been shown to be useful in inhibiting the enzymes that are responsible for the development of resistance and hence enhance the insecticide susceptibility of Anopheles gambiae sensu lato (s...
August 17, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28815867/baseline-susceptibility-of-spotted-wing-drosophila-drosophila-suzukii-to-four-key-insecticide-classes
#11
Steven Van Timmeren, David Mota-Sanchez, John C Wise, Rufus Isaacs
BACKGROUND: The invasive drosophilid pest, Drosophila suzukii Matsumura, is affecting berry production in most fruit-producing regions of the world. Chemical control is the dominant management approach, creating concern for insecticide resistance in this pest. We compared the insecticide susceptibility of D. suzukii populations collected from conventional, organic, or insecticide-free blueberry sites. RESULTS: The sensitivity of D. suzukii to malathion and spinetoram declined slightly across the three years of monitoring, whereas it was more consistent for methomyl and zeta-cypermethrin...
August 16, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28815728/effects-of-bifenthrin-exposure-on-the-estrogenic-and-dopaminergic-pathways-in-zebrafish-embryos-and-juveniles
#12
Luísa Becker Bertotto, Jaben Richards, Jay Gan, David Christopher Volz, Daniel Schlenk
Bifenthrin (BF) is a pyrethroid insecticide used in urban and agricultural applications. Previous studies have shown that environmentally relevant (ng/L) concentrations of BF increased plasma concentrations of 17β-estradiol (E2) and altered the expression of dopaminergic (DA) pathway components. DA neurons can indirectly regulate E2 biosynthesis, suggesting that BF may disrupt the hypothalamic-pituitary-gonadal (HPG) axis. Since embryos do not have a complete HPG axis, the hypothesis that BF impairs DA regulation was tested in embryonic and one-month old juvenile zebrafish (Danio rerio) with exposure to measured concentrations of 0...
August 16, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28814307/which-intervention-is-better-for-malaria-vector-control-insecticide-mixture-long-lasting-insecticidal-nets-or-standard-pyrethroid-nets-combined-with-indoor-residual-spraying
#13
Corine Ngufor, Josias Fagbohoun, Jessica Critchley, Raphael N'Guessan, Damien Todjinou, David Malone, Martin Akogbeto, Mark Rowland
BACKGROUND: Malaria control today is threatened by widespread insecticide resistance in vector populations. The World Health Organization (WHO) recommends the use of a mixture of unrelated insecticides for indoor residual spraying (IRS) and long-lasting insecticidal nets (LNs) or as a combination of interventions for improved vector control and insecticide resistance management. Studies investigating the efficacy of these different strategies are necessary. METHODS: The efficacy of Interceptor(®) G2 LN, a newly developed LN treated with a mixture of chlorfenapyr (a pyrrole) and alpha-cypermethrin (a pyrethroid), was compared to a combined chlorfenapyr IRS and Interceptor(®) LN (a standard alpha-cypermethrin LN) intervention in experimental huts in Cove Southern Benin, against wild, free-flying, pyrethroid-resistant Anopheles gambiae s...
August 16, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28811174/subchronic-exposure-to-sublethal-dose-of-imidacloprid-changes-electrophysiological-properties-and-expression-pattern-of-nicotinic-acetylcholine-receptor-subtypes-in-insect-neurosecretory-cells
#14
Yassine Benzidane, Delphine Goven, Aly Ahmed Abd-Ella, Caroline Deshayes, Bruno Lapied, Valérie Raymond
Neonicotinoids are the most important class of insecticides used in agriculture over the last decade. They act as selective agonists of insect nicotinic acetylcholine receptors (nAChRs). The emergence of insect resistance to these insecticides is one of the major problems, which limit the use of neonicotinoids. The aim of our study is to better understand physiological changes appearing after subchronic exposure to sublethal doses of insecticide using complementary approaches that include toxicology, electrophysiology, molecular biology and calcium imaging...
August 12, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28810872/-repel-all-biters-an-enhanced-collection-of-endophilic-anopheles-gambiae-and-anopheles-arabiensis-in-cdc-light-traps-from-the-kagera-region-of-tanzania-in-the-presence-of-a-combination-mosquito-net-impregnated-with-piperonyl-butoxide-and-permethrin
#15
Corey LeClair, Judith Cronery, Enock Kessy, Elsa V E Tomás, Yohannes Kulwa, Franklin W Mosha, Mark Rowland, Natacha Protopopoff, J Derek Charlwood
BACKGROUND: Mosquito nets containing synergists designed to overcome metabolic resistance mechanisms in vectors have been developed. These may enhance excitability in the mosquitoes and affect how they respond to CDC light-traps. Investigating the behaviour of vectors of disease in relation to novel mosquito nets is, therefore, essential for the design of sampling and surveillance systems. METHODS: In an initial experiment in Muleba, Tanzania, nine bedrooms from three housing clusters were sampled...
August 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28810866/the-development-of-an-ivermectin-based-attractive-toxic-sugar-bait-atsb-to-target-anopheles-arabiensis
#16
Frank Chelestino Tenywa, Athumani Kambagha, Adam Saddler, Marta Ferreira Maia
BACKGROUND: An increasing number of countries in sub-Saharan Africa are moving towards malaria-elimination, mostly thanks to successful vector control campaigns. However, elimination has proven challenging, resulting in the persistence of malaria transmission. It is now accepted that in order to eliminate malaria, new complementary vector control approaches must be developed. This study describes the development of a sugar-baited resting place containing a toxic dose of ivermectin for the control of Anopheles arabiensis...
August 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28810861/the-implementation-of-long-lasting-insecticidal-bed-nets-has-differential-effects-on-the-genetic-structure-of-the-african-malaria-vectors-in-the-anopheles-gambiae-complex-in-dielmo-senegal
#17
Seynabou Sougoufara, Cheikh Sokhna, Nafissatou Diagne, Souleymane Doucouré, Pape MBacké Sembène, Myriam Harry
BACKGROUND: Mosquitoes belonging to the Anopheles gambiae complex are the main vectors of malaria in sub-Saharan Africa. Among these, An. gambiae, Anopheles coluzzii and Anopheles arabiensis are the most efficient vectors and are largely distributed in sympatric locations. However, these species present ecological and behavioural differences that impact their vectorial capacity and complicate vector-control efforts, mainly based on long-lasting insecticidal bed nets (LLINs) and indoor residual spraying (IRS)...
August 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28809107/synthesis-and-insecticidal-activity-of-enzyme-triggered-functionalized-hollow-mesoporous-silica-for-controlled-release
#18
Amir Esmat Kaziem, Yunhao Gao, Shun He, Jianhong Li
In the present study, enzymatic responsive controlled release formulations (CRFs) were fabricated. The CRFs were achieved by anchoring mechanically interlocked molecules using α-cyclodextrin onto the surface pore rims of hollow mesoporous silica (HMS). The CRFs were characterized using Fourier transform infrared spectroscopy, scanning electron microscope, transmission electron microscope, and thermogravimetric analysis. The results showed that the CRFs had extraordinary loading ability for chlorantraniliprole (42% w/w) and could effectively preserve chlorantraniliprole against degradation under thermal conditions and UV radiation...
August 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28808317/bumblebee-colony-development-following-chronic-exposure-to-field-realistic-levels-of-the-neonicotinoid-pesticide-thiamethoxam-under-laboratory-conditions
#19
Dara A Stanley, Nigel E Raine
Neonicotinoid pesticides are used in agriculture to reduce damage from crop pests. However, beneficial insects such as bees can come into contact with these pesticides when foraging in treated areas, with potential consequences for bee declines and pollination service delivery. Honeybees are typically used as a model organism to investigate insecticide impacts on bees, but relatively little is known about impacts on other taxa such as bumblebees. In this experiment, we chronically exposed whole mature bumblebee (Bombus terrestris) colonies to field-realistic levels of the neonicotinoid thiamethoxam (2...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807279/acaricidal-activity-of-fluralaner-against-ornithodoros-moubata-and-ornithodoros-erraticus-argasid-ticks-evaluated-through-in-vitro-feeding
#20
R Pérez-Sánchez, A Oleaga
Ornithodoros erraticus and Ornithodoros moubata are argasid tick vectors that transmit severe diseases such as African swine fever and human relapsing fever. Elimination of the synanthropic populations of these vectors would facilitate the control of these diseases. Fluralaner is a novel isoxazoline that selectively blocks the GABA- and glutamate-gated channels, providing potent insecticidal and acaricidal activity. The aim of the current study was to provide quantitative data on the susceptibility of males, females and third nymphal instar of O...
August 30, 2017: Veterinary Parasitology
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