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https://www.readbyqxmd.com/read/29783663/clinical-and-molecular-aspects-of-vitiligo-treatments
#1
REVIEW
Anuradha Bishnoi, Davinder Parsad
Vitiligo is an asymptomatic but cosmetically disfiguring disorder that results in the formation of depigmented patches on skin and/or mucosae. Vitiligo can be segmental or non-segmental depending upon the morphology of the clinical involvement. It can also be classified as progressing or stable based on the activity of the disease. Further, the extent of involvement can be limited (localized disease) or extensive (generalized disease). The treatment of vitiligo therefore depends on the clinical classification/characteristics of the disease and usually comprises of 2 strategies...
May 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29781089/the-effect-of-topical-piperine-combined-with-narrowband-uvb-on-vitiligo-treatment-a-clinical-trial-study
#2
Anoosh Shafiee, Mahmood Hoormand, Mohammad Shahidi-Dadras, Alireza Abadi
Vitiligo is the most common acquired hypopigmentary disease in the community. Piperine as an herbal extract derived from black pepper has strong impact on the melanocyte proliferation and adverse side effects less than synthetic drugs such as corticosteroids. For the first time, this study was aimed to evaluate the effect of topical piperine combined with narrowband ultraviolet B (NB-UVB) on vitiligo treatment. In this double-blind clinical trial, 63 patients with facial vitiligo were randomly divided into 2 groups: treated with piperine (case) and placebo (control)...
May 21, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29741410/management-of-resistant-halo-nevi
#3
Sherif S Awad, Rasha Ta Abdel Aziz, Sahar S Mohammed
BACKGROUND: Halo nevus (HN) is a rare dermatologic disorder characterized by typical whitish rim surrounding an existing melanocytic nevus resembling halo. It is a cosmetic problem that may be linked to vitiligo, and it is advised to remove these nevi in order to avoid development of vitiligo. OBJECTIVES: The aim of the present study is to evaluate the cosmetic outcome after nevus removal and leukoderma dermabrasion with epithelial graft followed by narrow-band ultraviolet B (NB-UVB) phototherapy as management of resistant halo nevi and avoidance of development of vitiligo...
May 9, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29731587/suction-blister-epidermal-grafting-for-vitiligo-involving-angles-of-lip-experience-of-112-patients
#4
Bikash R Kar, Chinmoy Raj
Background: Lip vitiligo is usually resistant to medical modalities of treatment, and in all these cases, surgery offers a hope. Suction blister grafting (SBG) has been tried since long for lip vitiligo with high rate of success. There have been no long-term follow-up studies of patients with SBG at a difficult-to-treat site like angles of lip, which prompted us to conduct this study. Aims and Objectives: To assess the pigmentation rate and patient satisfaction of SBG on vitiligo involving angles of lip...
January 2018: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29707867/combination-of-fractional-carbon-dioxide-laser-with-narrow-band-ultraviolet-b-to-induce-repigmentation-in-stable-vitiligo-a-comparative-study
#5
Noha Nabil Doghaim, Shereen Farouk Gheida, Rania Ahmed El-Tatawy, Dareen Abdelaziz Mohammed Ali
BACKGROUND: Despite the numerous treatment modalities available for vitiligo, responses to treatment are still unsatisfactory. For this reason, new treatment modalities and approaches are needed. OBJECTIVE: To evaluate the efficacy and safety of fractional carbon dioxide (CO2 ) laser therapy followed by narrow band ultraviolet-B (NB-UVB) phototherapy on stable resistant vitiligo. SUBJECTS AND METHODS: Thirty-two patients with stable bilateral vitiligo were enrolled...
April 30, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29671735/how-tattoos-can-complement-breast-reconstruction
#6
Lisa Franczak
Tattooing offers expanded possibilities for creative expression for women who have undergone mastectomies and breast reconstruction surgeries. Tattoo techniques for areola restoration, such as repigmentation, do not address breast asymmetry or heavy scarring, but breast tattoos can embolden a woman's sexuality, self-confidence, and sense of body reclamation, as well as strengthen her postsurgical capacity for relating to her breasts and expressing her identity. There are many factors involved when a tattoo artist is asked to design an image for a patient...
April 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29619991/accelerated-repigmentation-of-vitiligo-after-an-irritant-reaction-following-occlusion-dressing-with-topical-tacrolimus
#7
Hyun Jeong Ju, Ji Hye Lee, Gyong Moon Kim, Chul Jong Park, Jung Min Bae
No abstract text is available yet for this article.
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29615444/home-interventions-and-light-therapy-for-the-treatment-of-vitiligo-hi-light-vitiligo-trial-study-protocol-for-a-randomised-controlled-trial
#8
Rachel H Haines, Kim S Thomas, Alan A Montgomery, Jane C Ravenscroft, Perways Akram, Joanne R Chalmers, Diane Whitham, Lelia Duley, Viktoria Eleftheriadou, Garry Meakin, Eleanor J Mitchell, Jennifer White, Andy Rogers, Tracey Sach, Miriam Santer, Wei Tan, Trish Hepburn, Hywel C Williams, Jonathan Batchelor
INTRODUCTION: Vitiligo is a condition resulting in white patches on the skin. People with vitiligo can suffer from low self-esteem, psychological disturbance and diminished quality of life. Vitiligo is often poorly managed, partly due to lack of high-quality evidence to inform clinical care. We describe here a large, independent, randomised controlled trial (RCT) assessing the comparative effectiveness of potent topical corticosteroid, home-based hand-held narrowband ultraviolet B-light (NB-UVB) or combination of the two, for the management of vitiligo...
April 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29573480/the-role-of-phototherapy-in-the-surgical-treatment-of-vitiligo-a-systematic-review
#9
REVIEW
J E Lommerts, S E Uitentuis, M W Bekkenk, M A de Rie, A Wolkerstorfer
Vitiligo is frequently treated with the combination of phototherapy and melanocyte transplantation. However, the additional benefit of phototherapy is unclear. Moreover, the optimal type and regimen of phototherapy are unknown. The objective of this systematic review was to identify whether phototherapy improves the outcome of melanocyte transplantation in vitiligo. We searched and screened for eligible studies in the databases of MEDLINE, EMBASE and CENTRAL. We included all clinical studies investigating melanocyte transplantation combined with phototherapy...
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29532621/comparison-between-the-efficacy-of-microneedling-combined-with-5-fluorouracil-vs-microneedling-with-tacrolimus-in-the-treatment-of-vitiligo
#10
Mary Mina, Lamia Elgarhy, Hanan Al-Saeid, Zeinab Ibrahim
BACKGROUND: Several treatment modalities had been used for the treatment of vitiligo, but the optimal treatment has not yet been identified. OBJECTIVES: To study the efficacy of microneedling with 5-flurouracil vs its efficacy with tacrolimus in the treatment of vitiligo. PATIENTS AND METHODS: Twenty-five patients with vitiligo were subjected to microneedling of 2 patches of vitiligo with dermapen, then application of 5-fluorouracil to 1 patch and tacrolimus on the other patch...
March 12, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29524288/effect-of-narrow-band-ultraviolet-b-on-the-serum-of-25-hydroxyvitamin-d-in-vitiligo-patients
#11
Hassan Ibrahim, Moustafa El Taieb, Zeinab El Gamel, Abdel Rahman El Saied
BACKGROUND: Narrow-band ultraviolet B (NB-UVB) is the gold standard in the treatment of vitiligo. 25-hydroxyvitamin D (25-OH- vitamin D) might play a physiological role in photo-induced melanogenesis in human skin so the association between vitamin D levels and vitiligo still needs to be investigated more thoroughly. OBJECTIVE: we aim to investigate the influence of cumulative doses of NB-UVB phototherapy on vitamin D in patients with vitiligo and their correlation with NB-UVB-induced pigmentation...
March 10, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29512683/a-novel-psoralen-derivative-mpfc-enhances-melanogenesis-via-activation-of-p38-mapk-and-pka-signaling-pathways-in-b16-cells
#12
Li Yin, Guangxian Pang, Chao Niu, Maidina Habasi, Jun Dou, Haji Akber Aisa
As an active compound, psoralen is present in various Chinese herbal medicines and has exhibited significant activity in skin disease treatment. Its derivative 8-methoxypsoralan (8-MOP) is the most commonly used drug to induce repigmentation of vitiligo. In our previous screening assays, 4-methyl-6-phenyl-2H-furo[3,2-g]chromen-2-one (MPFC), a psoralen derivative, was identified as more effective tyrosinase and melanin activator than the positive control 8-MOP in consideration of low doses, as well as low toxicity...
June 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29483980/an-innovative-therapeutic-protocol-for-vitiligo-experience-with-the-use-of-fraxel-herbium-laser-topical-latanoprost-and-successive-irradiation-with-uva-1-laser
#13
Torello Lotti, Uwe Wollina, Georgi Tchernev, Yan Valle, Jacopo Lotti, Katlein França, Francesca Satolli, Miriam Rovesti, Michael Tirant, Ilia Lozev, Ivan Pidakev, Serena Gianfaldoni
Despite the continuous introduction of innovative therapies for vitiligo, today none of them provide constant and excellent results in term of repigmentation. The authors report their experience in treating a localised form of vitiligo with a new protocol consisting in the use of a Fraxel Herbium laser, and in the following application of topical Latanoprost solution and, one day after, in lesional irradiation with UVA1 laser.
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29483979/micro-focused-phototherapy-associated-to-janus-kinase-inhibitor-a-promising-valid-therapeutic-option-for-patients-with-localized-vitiligo
#14
Serena Gianfaldoni, Georgi Tchernev, Uwe Wollina, Maria Grazia Roccia, Massimo Fioranelli, Jacopo Lotti, Miriam Rovesti, Francesca Satolli, Yan Valle, Andy Goren, Michael Tirant, Mirna Situm, Maja Kovacevic, Katlein França, Torello Lotti
BACKGROUND: Vitiligo is an acquired pigmentary cutaneous disease, characterised by the progressive loss of melanocytes, resulting in hypopigmented skin areas which progressively become amelanotic. Classically, vitiligo treatments are unsatisfactory and challenging. Despite the continuous introduction of new therapies, phototherapy is still the mainstay for vitiligo repigmentation. AIM: The aim of this multicenter observational retrospective study was to evaluate the efficacy and safety of the nb - UVB micro - phototherapy (BIOSKIN EVOLUTION®), used alone or in associations with an oral Janus kinase inhibitor (Tofacitinib citrate), in the treatment of stable or active forms of localised vitiligo...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29454011/comparative-study-on-some-oxidative-stress-parameters-in-blood-of-vitiligo-patients-before-and-after-combined-therapy
#15
A Zheleva, G Nikolova, Y Karamalakova, E Hristakieva, R Lavcheva, V Gadjeva
Currently accepted that oxidative stress is a triggering event in the melanocytic destruction and is probably involved in the etiopathogenesis of vitiligo disease. Despite numerous investigations, contradictory results were reported about the levels of oxidative stress biomarkers measured in the skin and blood of vitiligo patients. By Electron Paramagnetic Resonance spectroscopy (EPR) and spectrophotometry, we have investigated and compared some oxidative stress biomarkers in the blood of vitiligo patients' before and after UVB Narrow Band 311 nm phototherapy combined with the antioxidant nutritional supplement containing - Vitamin C, Vitamin B1, L -Cysteine, Lipoic Acid, and polyunsaturated fatty acids...
April 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29436008/treatment-outcomes-of-vitiligo-in-asian-children
#16
Evelyn Yuxin Tay, Cui Lian Vanessa Chong, Wen Jie Jonathan Paul Chong, Yiping Emily Gan, Sai Yee Chuah, Wei Ding Virlynn Tan, Tien Guan Steven Thng
This retrospective study aimed to identify factors that predict treatment response in a cohort of Asian children with vitiligo. Shorter duration of vitiligo was associated with better repigmentation. Patients with focal vitiligo of short duration have a good chance of achieving repigmentation with topical agents alone.
March 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29398855/to-compare-the-gingival-melanin-repigmentation-after-diode-laser-application-and-surgical-removal
#17
Gaurav Mahajan, Harjit Kaur, Sanjeev Jain, Navnit Kaur, Navneet Kaur Sehgal, Aditi Gautam
Aim: The aim of the present study is to compare the gingival melanin repigmentation after diode laser application and surgical removal done by scraping with Kirkland knife. Materials and Methods: This study was a randomized split-mouth study where 10 patients presenting with unattractive, diffuse, dark brown to black gingival discoloration on the facial aspect of the maxillary gingiva were treated by diode laser application and surgical removal and followed up for 3-, 6-, and 9-month intervals...
March 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29387874/combination-of-follicular-and-epidermal-cell-suspension-as-a-novel-surgical-approach-in-difficult-to-treat-vitiligo-a-randomized-clinical-trial
#18
Muhammed Razmi T, Ravinder Kumar, Seema Rani, Sendhil M Kumaran, Sushma Tanwar, Davinder Parsad
Importance: Epidermal cell suspension (ECS) and follicular cell suspension (FCS) are successful surgical modalities for the treatment of stable vitiligo. However, repigmentation in generalized and acrofacial vitiligo and over acral or bony sites (eg, elbows, knees, iliac crests, and malleoli), which are difficult to treat, is challenging. Objective: To study the efficacy of transplanting a combination of autologous, noncultured ECS and FCS (ECS + FCS) compared with ECS alone in stable vitiligo...
March 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29387870/rapid-repigmentation-of-vitiligo-using-tofacitinib-plus-low-dose-narrowband-uv-b-phototherapy
#19
Sa Rang Kim, Henry Heaton, Lucy Y Liu, Brett A King
No abstract text is available yet for this article.
March 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29364459/optimizing-suction-blister-epidermal-graft-technique-in-the-surgical-treatment-of-vitiligo
#20
Gerson Dellatorre, Wagner Bertolini, Caio Cesar Silva de Castro
Surgical management of vitiligo is considered an excellent terapeutic option for recalcitrant cases, provided the disease is stable and there is absence of Koebner phenomenom. Among surgical modalities, Suction Blister Epidermal Graft is a low cost and effective option (65 to 100% repigmentation can be achieved in up to 80% of patients). We describe how it can be optimized by using an alternative suction equipment, by customization of graft format and by application of an anesthetic technique that substantially reduces procedure time...
November 2017: Anais Brasileiros de Dermatologia
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