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https://www.readbyqxmd.com/read/28425237/the-efficacy-of-narrowband-uvb-treatment-in-pediatricvitiligo-a-retrospective-analysis-of-26-cases
#1
Serkan Yazici, Berrin Günay, Emel Bülbül Başkan, Kenan Aydoğan, Hayriye Saricaoğlu, Şükran Tunali
BACKGROUND/AIM: Narrowband UVB (Nb UVB) treatment is commonly used for the management of psoriasis and atopic dermatitis, and is less often used for vitiligo in children. The aim of this study was to evaluate the efficacy and short-term safety of Nb UVB phototherapy in children diagnosed with vitiligo retrospectively. MATERIALS AND METHODS: A total of 26 patients younger than 18 years with the diagnosis of vitiligo and managed with Nb UVB phototherapy as documented in archive records were evaluated...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28419984/topical-histamine-stimulates-repigmentation-of-nonsegmental-vitiligo-by-a-receptor-dependent-mechanism
#2
Jun Liu, Yan Xu, Tzu-Kai Lin, Chengzhi Lv, Peter M Elias, Mao-Qiang Man
BACKGROUND: Though vitiligo is a common depigmentary disorder, it still represents a substantial therapeutic challenge. Therapeutic options are limited in part due to its uncertain etiology. OBJECTIVE: Because recent studies suggest that histamine stimulates melanogenesis in vitro, we determined here whether topical histamine stimulates repigmentation in patients with stable, nonsegmental vitiligo. METHODS: A total of 23 otherwise normal volunteers with vitiligo, including 14 males and 9 females aged 6-59 years (mean age 29...
April 19, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28403523/autologous-cell-suspension-grafting-in-segmental-vitiligo-and-piebaldism-a-randomised-controlled-trial-comparing-full-surface-and-fractional-co2-laser-recipient-site-preparations
#3
J E Lommerts, A A Meesters, L Komen, M W Bekkenk, M A de Rie, R M Luiten, A Wolkerstorfer
BACKGROUND: Autologous non-cultured cell suspension transplantation is an effective treatment for repigmentation in segmental vitiligo and piebaldism. Full surface laser ablation is frequently used to prepare the recipient site before cell suspension transplantation, even though optimal laser settings and ablation depth are unknown. OBJECTIVES: To assess the efficacy and safety of less invasive recipient site preparations. METHODS: In a randomised, observer-blinded, controlled trial we compared different recipient site preparations before cell suspension transplantation in segmental vitiligo and piebaldism...
April 12, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28392666/successful-repigmentation-of-vitiligo-like-hypopigmentation-in-a-case-of-acanthosis-nigricans
#4
Seung Hyun Chun, Ji Hyun Park, Jae Beom Park, Il-Hwan Kim
No abstract text is available yet for this article.
April 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28390737/treatment-of-vitiligo-with-the-topical-janus-kinase-inhibitor-ruxolitinib
#5
Brooke Rothstein, Deep Joshipura, Ami Saraiya, Rana Abdat, Huda Ashkar, Yana Turkowski, Vaneeta Sheth, Victor Huang, Shiu Chung Au, Courtney Kachuk, Nicole Dumont, Alice B Gottlieb, David Rosmarin
BACKGROUND: Existing therapies for vitiligo are limited in efficacy and can be associated with undesirable side effects. Topical Janus kinase inhibitors may offer a new therapeutic option for vitiligo. OBJECTIVE: We sought to assess the role of topical ruxolitinib 1.5% cream, a Janus kinase inhibitor, in vitiligo treatment. METHODS: This 20-week, open-label, proof-of-concept trial of twice-daily topical ruxolitinib 1.5% cream was conducted in 12 patients with a minimum of 1% affected body surface area of vitiligo...
April 5, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28355423/phototherapy-for-vitiligo-a-systematic-review-and-meta-analysis
#6
Jung Min Bae, Han Mi Jung, Bo Young Hong, Joo Hee Lee, Won Joon Choi, Ji Hae Lee, Gyong Moon Kim
Importance: References to the expected treatment response to phototherapy would be helpful in the management of vitiligo because phototherapy requires long treatment durations over several months. Objective: To estimate the treatment response of vitiligo to phototherapy. Data Sources: A comprehensive database search of MEDLINE, EMBASE, and the Cochrane library from inception to January 26, 2016, was performed for all prospective studies. The main keywords used were vitiligo, phototherapy, psoralen, PUVA, ultraviolet, NBUVB, and narrowband...
March 29, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28318054/efficacy-and-safety-of-targeted-high-intensity-medium-band-304-312-nm-ultraviolet-b-light-in-pediatric-vitiligo
#7
Da-Ke Dong, Zhan-Yan Pan, Juan Zhang, Xue-Fen Lu, Cheng Jin, Shi-Qin Tao, Li-Jia Yang
BACKGROUND/OBJECTIVES: Phototherapy is a commonly used treatment for vitiligo that has demonstrated safety and efficacy. High-intensity targeted ultraviolet B (UVB) light (304-312 nm) delivered using a phototherapy device is a useful therapeutic option because it can induce repigmentation in a short time without global exposure to radiation, but information regarding this device in children is limited. METHODS: We performed a retrospective analysis of 95 patches of vitiligo in 27 children treated using a targeted phototherapy device...
March 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28317534/vitiligo-pathogenesis-and-emerging-treatments
#8
REVIEW
Mehdi Rashighi, John E Harris
The pathogenesis of vitiligo involves interplay between intrinsic and extrinsic melanocyte defects, innate immune inflammation, and T-cell-mediated melanocyte destruction. The goal of treatment is to not only halt disease progression but also promote repigmentation through melanocyte regeneration, proliferation, and migration. Treatment strategies that address all aspects of disease pathogenesis and repigmentation are likely to have greatest efficacy, a strategy that may require combination therapies. Current treatments generally involve nontargeted suppression of autoimmunity, whereas emerging treatments are likely to use a more targeted approach based on in-depth understanding of disease pathogenesis, which may provide higher efficacy with a good safety profile...
April 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28317530/depigmentation-therapies-for-vitiligo
#9
REVIEW
Pearl E Grimes, Rama Nashawati
The general goals of medical management of vitiligo are to repigment vitiliginous areas of skin and to stabilize the progression of depigmentation. However, for some patients with vitiligo affecting extensive body surface areas who are unresponsive to repigmentation therapies, depigmentation of the remaining normal skin may be a better choice. Candidates for depigmentation therapy should be carefully screened and patient education is essential. Permanent topical therapies used for depigmentation include monobenzyl ether of hydroquinone, 4-methoxyphenol, and 88% phenol...
April 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28317529/repigmentation-through-melanocyte-regeneration-in-vitiligo
#10
REVIEW
Stanca A Birlea, Nathaniel B Goldstein, David A Norris
Repigmentation in vitiligo is the process that replaces, in the epidermal basal layer of vitiligo skin, the mature melanocytes that have been killed by cytotoxic T cells specific for melanocyte antigens. It consists of mobilization of melanocyte precursors in the hair follicle bulge and infundibulum to proliferate, migrate, and differentiate into mature melanocytes, moving from the hair follicle bulge to the interfollicular epidermis. The most common clinical presentation of repigmentation in vitiligo is the perifollicular pattern...
April 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28317528/surgical-therapies-for-vitiligo
#11
REVIEW
Tasneem F Mohammad, Iltefat H Hamzavi
Surgical management is a safe and effective treatment modality for select patients with vitiligo. Many techniques of vitiligo surgery exist, each with unique advantages and disadvantages. Preoperative screening for appropriate candidates, selection of surgical technique, and postoperative management are all key elements in enabling patients to achieve maximal repigmentation.
April 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28317526/medical-and-maintenance-treatments-for-vitiligo
#12
REVIEW
Thierry Passeron
Medical treatments alone, or in combination with phototherapy, are key approaches for treating nonsegmental vitiligo and, to a lesser extent, segmental vitiligo. The treatments are useful for halting disease progression and have been proven effective for inducing repigmentation and decreasing risk of relapses. Although the treatments have side effects and limitations, vitiligo often induces a marked decrease in quality of life and in most cases the risk:benefit ratio is in favor of an active approach. Systemic and topical agents targeting the pathways involved in loss of melanocytes and in differentiation of melanocyte stem cells should provide more effective approaches in the near future...
April 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28317522/skin-cancer-risk-nonmelanoma-skin-cancers-melanoma-in-vitiligo-patients
#13
REVIEW
Michelle Rodrigues
The relative genetic and immune protection against melanoma and nonmelanoma skin cancers in those with vitiligo is reassuring. The results of recent studies allow us to be cautiously optimistic when discussing the risk of skin cancer caused by therapeutic exposure to narrow-band ultraviolet B light. However, we should continue to recommend sun protection at all other times to avoid burning in vitiliginous skin and to decrease incidental ultraviolet exposure. It is also important to perform full skin checks regularly in light of the prolonged courses of phototherapy required to repigment vitiliginous skin and maintain repigmentation thereafter...
April 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28314912/differences-in-the-melanosome-distribution-within-the-epidermal-melanin-units-and-its-association-with-the-impairing-background-of-leukoderma-in-vitiligo-and-halo-nevi-a-retrospective-study
#14
Xi-Xi Xiong, Gao-Zhong Ding, Wen-E Zhao, Xue Li, Yu-Ting Ling, Li Sun, Qing-Li Gong, Yan Lu
Skin color is determined by the number of melanin granules produced by melanocytes that are transferred to keratinocytes. Melanin synthesis and the distribution of melanosomes to keratinocytes within the epidermal melanin unit (EMU) within the skin of vitiligo patients have been poorly studied. The ultrastructure and distribution of melanosomes in melanocytes and surrounding keratinocytes in perilesional vitiligo and normal skin were investigated using transmission electron microscopy (TEM). Furthermore, we performed a quantitative analysis of melanosome distribution within the EMUs with scatter plot...
March 17, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28272910/punch-graft-versus-follicular-hair-transplantation-in-the-treatment-of-stable-vitiligo
#15
Essam-Elden Mohamed Mohamed, Abdel-Khalek Younes, Ahmed Osman, Refaat Mohamed, Mahmoud Makki, Marwa Younis
OBJECTIVE: To compare the efficacy of follicular hair transplantation and mini punch graft in the treatment of stable vitiligo. METHODS: Thirty two patients with stable vitiligo were included in this comparative study. A single patch from each patient was divided into two halves; one half was treated by punch graft while the other half was treated by follicular hair transplantation followed by excimer light twice weekly and the outcome were assessed at 0, 1, 3and 6 months post operatively by photography and quartile scale...
March 8, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28265789/depigmentation-with-q-switched-nd-yag-laser-in-universal-vitiligo-a-long-term-follow-up-study-of-4%C3%A2-years
#16
Imran Majid, Saher Imran
Q-switched (QS) lasers are used for depigmentation in universal vitiligo, but there is limited data on long-term results after laser treatment. This study was conducted to assess the safety and long-term follow-up results of QS Nd:YAG laser treatment in combination with need-based topical depigmentation therapy for universal vitiligo. A retrospective study was performed on patients with universal vitiligo who had received QS Nd:YAG laser treatment from 2010 to 2013. All patients were contacted and called for follow-up...
March 7, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28163468/use-of-dermatoscope-to-monitor-the-repigmentation-of-various-vitiligo-surgical-procedures
#17
Balakrishnan Nirmal
No abstract text is available yet for this article.
October 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28163453/reduction-of-blister-formation-time-in-suction-blister-epidermal-grafting-in-vitiligo-patients-using-a-household-hair-dryer
#18
Shweta Arora, Bikash Ranjan Kar
BACKGROUND: Suction blister epidermal grafting (SBEG) is a simple and effective way of surgical repigmentation in vitiligo. The major problem faced is the time taken for the formation of blisters. Temperature at the suction site is one of the factors affecting the blister formation time. AIMS AND OBJECTIVES: To reduce the blister formation time in SBEG by increasing the surface temperature to 44°C. MATERIALS AND METHODS: This is a left-right comparison study...
October 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28157763/effect-of-procedural-related-variables-on-melanocyte-keratinocyte-suspension-transplantation-in-nonsegmental-stable-vitiligo-a-clinical-and-immunocytochemical-study
#19
MULTICENTER STUDY
Bakr Mohamed El-Zawahry, Samia Esmat, Dalia Bassiouny, Naglaa Sameh Zaki, Rehab Sobhi, Marwah A Saleh, Dalia Abdel-Halim, Rehab Hegazy, Heba Gawdat, Nesrin Samir, Marwa El-Hawary, Zeinab El Maadawi, Heba Gouda, Mervat Khorshied
BACKGROUND: Melanocyte-keratinocyte suspension (M-K susp) is gaining popularity for vitiligo treatment. Few studies have addressed procedure-related variables. OBJECTIVE: To assess the effect of different M-K susp procedure-related variables on the clinical outcome in stable vitiligo. METHODS: This prospective multicenter comparative study included 40 cases with nonsegmental stable vitiligo. Donor site was either a skin graft in noncultured epidermal cell suspension (NCECS) or hair follicle units in outer root sheath hair follicle suspension (ORSHFS)...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28157762/ultrathin-skin-grafting-in-resistant-stable-vitiligo-a-follow-up-study-of-8-years-in-370-patients
#20
Imran Majid, Saher Imran
BACKGROUND: Ultrathin skin grafting (UTSG) is a tissue grafting technique used in resistant stable vitiligo. OBJECTIVE: To assess long-term follow-up results achieved with UTSG in vitiligo. METHODS: Over a span of 8 years, a total of 415 patients with stable vitiligo were treated with UTSG at the authors' institute. Retrospective analysis of results achieved in these patients was performed, and primary end points assessed included the extent and quality of repigmentation achieved and adverse effects from the procedure...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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