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large graft cornea

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https://www.readbyqxmd.com/read/28723714/vent-incisions-to-facilitate-peripheral-unfolding-of-the-dmek-graft
#1
Christopher Liu, Alfonso Vasquez-Perez, Jordan Vassileff Chervenkoff, Venkata Avadhanam
PURPOSE: To present the results of 15 cases in which a modified technique of Descemet membrane endothelial keratoplasty (DMEK) with vent incisions was used to assist unfolding of tight peripheral inward folds. METHODS: This is a retrospective case series of 15 consecutive eyes that underwent a modified vent incision technique for DMEK. Six oblique, small-size (1 mm) vent incisions parallel to the limbus and 3.5 mm from the center were performed after descemetorhexis...
July 17, 2017: Cornea
https://www.readbyqxmd.com/read/28700252/modified-allogenic-simple-limbal-epithelial-transplantation-followed-by-keratoplasty-as-treatment-for-total-limbal-stem-cell-deficiency
#2
Alfonso Vasquez-Perez, Mayank A Nanavaty
PURPOSE: To describe a modified allogenic simple limbal epithelial transplant (SLET) technique with large donor tissue explants followed by keratoplasty. METHODS: A 69-year-old with conjunctival melanoma on her left eye developed total limbal stem cell deficiency (LSCD) after multiple cycles of topical mitomycin. She also had herpes stromal keratitis while on treatment with mitomycin. She underwent modified allogenic SLET with large donor limbal tissue explants glued on the cornea directly and the amniotic membrane placed over the limbal explants...
July 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28665475/autologous-cultivated-limbal-stem-cell-transplantation-after-failed-previous-limbal-graft
#3
Karl A Knutsson, Stanislav Matuska, Paolo Rama
PURPOSE: To describe a case of unilateral limbal stem cell deficiency (LSCD) with previously failed autologous graft, resolved by ocular surface reconstruction using cultured autologous limbal stem cells from the contralateral eye. CASE REPORT: A 35-year-old patient presented to our clinic with LSCD due to a unilateral alkali burn. The patient had received a previous limbal graft from the contralateral eye that had failed to impede corneal conjunctivalization. We decided to repeat limbal stem cell transplantation using an ex vivo cultivation procedure to reduce the risk of tissue harvesting on the healthy fellow eye...
June 20, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28658437/indications-and-visual-outcomes-of-intrastromal-corneal-ring-segment-implantation-in-a-large-patient-series
#4
Taíse Tognon, Mauro Campos, João Paulo Wengrzynovski, Kleyton Arlindo Barella, Adriano Pasqualotti, Luiz Antônio de Brito Martins, Adriana Dos Santos Forseto, Luciene Barbosa de Sousa
OBJECTIVES: To describe the indications for and visual outcomes of intrastromal corneal ring segment implantation. METHODS: A large retrospective case-series chart-review study was conducted using Sorocaba Ophthalmological Hospital medical records. This study included 1222 eyes (1196 patients) that were surgically treated between November 2009 and December 2012. The following preoperative data were collected: age, gender, type of medical care and funding source, surgical technique, best-corrected visual acuity, manifest sphere and cylinder refractive error, maximum and minimum central keratometry, and pachymetry measurements of the cornea at the thinnest point and at the ring channel...
June 2017: Clinics
https://www.readbyqxmd.com/read/28544131/sclerocorneal-graft-and-sequential-removal-of-melted-cornea-after-severe-corneal-burn-with-perforation
#5
Anja Viestenz, Berthold Seitz, Hans-Gert Struck, Arne Viestenz
INTRODUCTION: Corneal burn grade IV usually leads to blindness. Several different surgical techniques remain challenging owing to the extensive tissue damage. Here, we introduce a novel technique with a 15 mm corneoscleral and limbal homologous graft combined with sequential autologous corneal removal ab interno, with a vitrectomy probe to save the anterior chamber angle. In vivo anatomy with optical coherence tomography is the surgical key. METHOD: A large 15 mm sclerocorneal graft is sutured on top of the remainder of the destroyed cornea and sclera after removal of the epithelium and conjunctiva, with anterior synechiolysis if necessary, peripheral iridectomy and conjunctivoplasty...
May 22, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28505675/-anti-lymph-angiogenic-strategies-to-improve-corneal-graft-survival
#6
Felix Bock, Claus Cursiefen
Corneal transplantation (keratoplasty) is the most frequently performed form of transplantation worldwide. A rejection reaction against the transplant is the main complication occurring after transplantation in an already vascularized, so-called "high-risk" recipient eye. Our group has shown that clinically invisible lymphatic vessels play a crucial role in the induction of a rejection reaction against the corneal graft, and that anti-(lymph)angiogenic therapies in the mouse model of keratoplasty can significantly improve transplant survival...
May 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28386160/a%C3%A2-serious-adverse-surgical-event-management-of-suspected-hsv-1-keratitis-in-a%C3%A2-donor-cornea
#7
Rebecca Kaye, Bernhard Steger, Jern Y Chen, Vito Romano
PURPOSE: To describe the management of a serious adverse event in a patient undergoing penetrating keratoplasty (PK). CASE REPORT: A 68-year-old man underwent PK for an aphakic bullous keratopathy following previous complicated cataract surgery. He had no past history of herpetic disease. Storage of the corneoscleral disc in the transport bottle precluded microscopic examination. After placement of the trephined donor cornea on the open eye of the recipient, a large dendritiform geographic ulcer was noted on the donor cornea...
2017: Spektrum der Augenheilkunde: Zeitschrift der Österreichischen Ophthalmologischen Gesellschaft, ÖOG
https://www.readbyqxmd.com/read/28060074/eventual-endothelial-failure-after-initial-corneal-clearing-after-a-detached-endothelial-graft-in-fuchs-dystrophy
#8
Hyunjoo J Lee, Wuqaas M Munir
PURPOSE: To report a case of eventual corneal endothelial cell failure after spontaneous resolution of corneal edema after failed Descemet membrane endothelial keratoplasty (DMEK). METHODS: Retrospective case report. RESULTS: A 56-year-old man with Fuchs endothelial corneal dystrophy underwent cataract and DMEK surgery in the left eye. The transplanted DMEK graft detached in the early postoperative period and formed a peripheral scroll. Despite graft detachment, corneal edema resolved with endothelial cell repopulation of the central cornea...
February 2017: Cornea
https://www.readbyqxmd.com/read/27996195/histological-and-clinical-evaluation-of-the-hard-palate-mucous-membrane-graft-for-treatment-of-lower-eyelid-retraction
#9
Sofie D H Larsen, Steffen Heegaard, Peter B Toft
PURPOSE: To evaluate the histological appearances of the epithelial cells and the clinical effect of the hard palate mucous membrane (HPM) graft for the treatment of lower eyelid retraction (LER). METHODS: This was a follow-up study involving 15 patients, with a total of 16 eyes operated. Five patients had LER as a result of Graves' ophthalmopathy and/or inferior rectus recession, six patients because of wearing an eye prosthesis, two patients because of previous tumour excision, one patient because of proptosis due to sphenoid wing meningioma and one patient because of previous lower eyelid blepharoplasty...
December 20, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27785556/-influence-of-the-donor-age-on-graft-survival-is-the-demographic-change-also-important-for-corneal-tissue-donation
#10
REVIEW
N Hofmann, M Derks, M Börgel, K Engelmann
The success of corneal transplantation highly depends on the quality of the used graft. Various factors play a crucial role such as a perfect stroma without optically relevant, centrally located cloudiness or changes (e. g. scars) or an adherent Descemet membrane. One of the most important parameters is the quality of the endothelial cell layer with a sufficiently large endothelial cell count. An open question is so far whether the donor age affects corneal quality and therefore has an impact on the success of transplantation...
May 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27370015/gr-1intcd11b-myeloid-derived-suppressor-cells-accumulate-in-corneal-allograft-and-improve-corneal-allograft-survival
#11
Wungrak Choi, Yong Woo Ji, Hwa-Yong Ham, Areum Yeo, Hyemi Noh, Su-Eon Jin, Jong Suk Song, Hyeon Chang Kim, Eung Kwon Kim, Hyung Keun Lee
We identified the characteristics of myeloid-derived suppressor cells (MDSCs) and investigated their mechanism of induction and their functional role in allograft rejection using a murine corneal allograft model. In mice, MDSCs coexpress CD11b and myeloid differentiation antigen Gr-1. Gr-1(+)CD11b(+) cells infiltrated allografted corneas between 4 d and 4 wk after surgery; however, the frequencies of Gr-1(+)CD11b(+) cells were not different between accepted and rejected allografts or in peripheral blood or BM...
December 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27315294/-pkp-for-keratoconus-from-hand-motor-trephine-to-excimer-laser-and-back-to-femtosecond-laser
#12
B Seitz, N Szentmáry, A Langenbucher, T Hager, A Viestenz, E Janunts, M El-Husseiny
For patients with keratoconus, rigid gas-permeable contact lenses are the first line correction method and allow good visual acuity for quite some time. In severe stages of the disease with major cone-shaped protrusion of the cornea, even specially designed keratoconus contact lenses are no longer tolerated. If there are contraindications for intrastromal ring segments, corneal transplantation typically has a very good prognosis. In patients with advanced keratoconus - especially after corneal hydrops due to rupture of Descemet's membrane - penetrating keratoplasty (PKP) is still the first line surgical method...
June 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27200258/aesthetic-total-reconstruction-of-lower-eyelid-using-scapha-cartilage-graft-on-a-vascularized-propeller-flap
#13
Tetsuji Uemura, Hidekata Watanabe, Kazuyuki Masumoto, Mamoru Kikuchi, Yoshiyasu Satake, Tetsu Yanai, Yoshimi Harada, Yasuhiro Ishihara, Masato Yasuta
BACKGROUND: The aim of this study was to review the results of a cohort of patients based on our experience with a new technique for total lower eyelid reconstruction after a large defect caused by malignant tumor and trauma. A scapha cartilage graft with small skin on a vascularized propeller flap was used for 16 cases requiring lower eyelid reconstruction. METHODS: Patients were identified from a database, and a retrospective case note review was conducted. The scapha cartilage graft was sutured to the margin of the defect of the palpebral conjunctiva and tarsus...
April 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27143848/the-use-of-dry-amniotic-membrane-in-pterygium-surgery
#14
REVIEW
Gelareh S Noureddin, Sonia N Yeung
Pterygium is a fibrovascular growth of the bulbar conjunctiva that crosses the limbus and extends over the peripheral cornea, in some cases resulting in significant visual morbidity. When treatment is indicated, surgery is necessary, and several management options exist. These include excision, conjunctival autografting, and the use of adjuvant therapies. This paper reviews the incidence and prevalence of pterygia and also describes the various techniques currently used to treat this condition. These management options are compared to the use of dry amniotic membrane grafting (AMG), specifically with regard to recurrence rates, time to recurrence, safety and tolerability, as well as patient factors including cosmesis and quality of life...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/26989954/tenons-patch-graft-in-the-management-of-large-corneal-perforations
#15
Sanita Korah, Satheesh S T Selvin, Zia S Pradhan, Pushpa Jacob, Thomas Kuriakose
PURPOSE: To describe a technique to manage corneal perforations between 3 and 6 mm in size using autologous Tenons tissue with cyanoacrylate glue and a bandage contact lens. METHODS: A thin layer of Tenons capsule harvested from the patient's own eye is used to seal the perforation and act as a scaffold. The Tenons patch graft is spread over the perforation and held in place by the application of cyanoacrylate glue. A bandage contact lens is then placed on the eye...
May 2016: Cornea
https://www.readbyqxmd.com/read/26937927/cost-minimization-analysis-of-precut-cornea-grafts-in-descemet-stripping-automated-endothelial-keratoplasty
#16
Kai-Ling Yong, Hai V Nguyen, Howard Y Cajucom-Uy, Valencia Foo, Donald Tan, Eric A Finkelstein, Jodhbir S Mehta
Descemet stripping automated endothelial keratoplasty (DSAEK) is the most common corneal transplant procedure. A key step in the procedure is preparing the donor cornea for transplantation. This can be accomplished via 1 of 3 alternatives: surgeon cuts the cornea on the day of surgery, the cornea is precut ahead of time in an offsite facility by a trained technician, or a precut cornea is purchased from an eye bank. Currently, there is little evidence on the costs and effectiveness of these 3 strategies to allow healthcare providers decide upon the preferred method to prepare grafts...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26788074/limbal-stem-cell-deficiency-current-treatment-options-and-emerging-therapies
#17
REVIEW
Michel Haagdorens, Sara Ilse Van Acker, Veerle Van Gerwen, Sorcha Ní Dhubhghaill, Carina Koppen, Marie-José Tassignon, Nadia Zakaria
Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular surface in advanced stem cell deficient corneas, an autologous or allogenic limbal stem cell transplantation is performed. In recent years, the risk of secondary LSCD due to removal of large limbal grafts has been significantly reduced by the optimization of cultivated limbal epithelial transplantation (CLET). Despite the great successes of CLET, there still is room for improvement as overall success rate is 70% and visual acuity often remains suboptimal after successful transplantation...
2016: Stem Cells International
https://www.readbyqxmd.com/read/26633035/global-survey-of-corneal-transplantation-and-eye-banking
#18
Philippe Gain, Rémy Jullienne, Zhiguo He, Mansour Aldossary, Sophie Acquart, Fabrice Cognasse, Gilles Thuret
IMPORTANCE: Corneal transplantation restores visual function when visual impairment caused by a corneal disease becomes too severe. It is considered the world's most frequent type of transplantation, but, to our knowledge, there are no exhaustive data allowing measurement of supply and demand, although such data are essential in defining local, national, and global strategies to fight corneal blindness. OBJECTIVE: To describe the worldwide situation of corneal transplantation supply and demand...
February 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/26632412/tectonic-lamellar-keratoplasty-using-cryopreserved-cornea-in-a-large-descemetocele
#19
Kang Yoon Kim, Ji Won Jung, Eung Kweon Kim, Kyoung Yul Seo, Tae Im Kim
We describe herein a case of an impending corneal perforation with a large descemetocele in a patient with previous penetrating keratoplasty (PKP) that subsequently was treated with an emergent lamellar keratoplasty using frozen preserved cornea. A 76-year-old male patient, who had a PKP, presented with a completely whitish and edematous graft accompanied by large epithelial defects. Although antibiotics and antiviral agents were tried for three days, the corneal stroma abruptly melted, except for the Descemet's membrane and endothelium...
January 2016: Yonsei Medical Journal
https://www.readbyqxmd.com/read/26600791/a-case-report-of-ablepharon-macrostomia-syndrome-with-amniotic-membrane-grafting
#20
Eric Feinstein, Aisha S Traish, Vinay Aakalu, Iris S Kassem
We describe a rare case of an infant who was born with multiple congenital anomalies, including the absence of eyelids. This patient had many dysmorphic features consistent with a severe phenotype of ablepharon-macrostomia syndrome (AMS) including a fish-like appearance of the mouth, rudimentary ears, absence of body hair, thin skin, absent nipples, abdominal distension, and genital abnormalities. Upon presentation, there was severe exposure keratopathy causing large bilateral sterile ulcers culminating in corneal melting of both eyes...
September 2015: Case Reports in Ophthalmology
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