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https://www.readbyqxmd.com/read/28095300/knockdown-of-cxcl14-disrupts-neurovascular-patterning-during-ocular-development
#1
Ana F Ojeda, Ravi P Munjaal, Peter Y Lwigale
The C-X-C motif ligand 14 (CXCL14) is a recently discovered chemokine that is highly conserved in vertebrates and expressed in various embryonic and adult tissues. CXCL14 signaling has been implicated to function as an antiangiogenic and anticancer agent in adults. However, its function during development is unknown. We previously identified novel expression of CXCL14 mRNA in various ocular tissues during development. Here, we show that CXCL14 protein is expressed in the anterior eye at a critical time during neurovascular development and in the retina during neurogenesis...
January 14, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28056553/quercetin-and-the-ocular-surface-what-we-know-and-where-we-are-going
#2
Tina B McKay, Dimitrios Karamichos
Flavonoids are a class of plant and fungus secondary metabolites that serve functional roles in protecting against UV-induced oxidative stress, mediating auxin signaling, and promoting microbial defense. Flavonoids are extremely abundant in nature where their potent antioxidant capacity and very low toxicity makes them highly attractive as potential therapeutic agents. In terms of clinical applications, neither the Food and Drug Administration (FDA) nor the European Food Safety Authority (EFSA) has approved any health claims or drugs related to the use of flavonoids for therapeutic purposes...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28055102/galectin-3-inhibition-by-a-small-molecule-inhibitor-reduces-both-pathological-corneal-neovascularization-and-fibrosis
#3
Wei-Sheng Chen, Zhiyi Cao, Hakon Leffler, Ulf J Nilsson, Noorjahan Panjwani
Purpose: Corneal neovascularization and scarring commonly lead to significant vision loss. This study was designed to determine whether a small-molecule inhibitor of galectin-3 can inhibit both corneal angiogenesis and fibrosis in experimental mouse models. Methods: Animal models of silver nitrate cautery and alkaline burn were used to induce mouse corneal angiogenesis and fibrosis, respectively. Corneas were treated with the galectin-3 inhibitor, 33DFTG, or vehicle alone and were processed for whole-mount immunofluorescence staining and Western blot analysis to quantify the density of blood vessels and markers of fibrosis...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28052006/subconjunctival-injection-of-antagomir-21-alleviates-corneal-neovascularization-in-a-mouse-model-of-alkali-burned-cornea
#4
Yun Zhang, Ting Zhang, Xiaoyun Ma, Jun Zou
Corneal neovascularization may result in loss of corneal transparency and blindness. However, developing successful and inexpensive medical treatments for corneal neovascularization remains an unresolved issue. Recently, several studies have implicated miRNA functions in the regulation of cornea homeostasis. This study aimed to identify the miRNA expression profile in the neovascularized cornea after an alkali burn and to investigate the related underlying mechanisms. Here, alkali-burned corneas and matched normal tissues were pooled to perform miRNA sequencing...
December 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/28025793/allogenic-cultivated-limbal-stem-cell-transplantation-versus-cadaveric-keratolimbal-allograft-in-ocular-surface-disorder-1-year-outcome
#5
Jitendra Kumar Singh Parihar, Avinash Singh Parihar, Vaibhav Kumar Jain, Jaya Kaushik, Pramod Nath
PURPOSE: To compare the outcome of allogenic ex vivo cultivated limbal stem cell transplantation (LSCT) versus cadaveric keratolimbal allograft in patients with limbal stem cell deficiency (LSCD). METHODS: In this prospective interventional study from Army Hospital Research and Referral in New Delhi, 50 eyes of 40 patients with ocular surface disorder having LSCD underwent either cultivated LSCT (group 1: 25 eyes of 20 patients) or keratolimbal allograft transplantation (group 2: 25 eyes of 20 patients)...
December 26, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/28012874/management-of-high-risk-corneal-transplantation
#6
REVIEW
Antonio Di Zazzo, Ahmad Kheirkhah, Tulio B Abud, Sunali Goyal, Reza Dana
The cornea is the most commonly transplanted tissue in medicine. The main cause of corneal graft failure is allograft rejection. The incidence of graft rejection depends on the presence of high-risk characteristics, most notably corneal neovascularization. Although corneal grafting has a high success rates in the absence of these risk factors, high-risk keratoplasty is associated with low success rates because of a high incidence of immune-mediated graft rejection. To improve the survival of high-risk corneal transplantation, various preoperative, intraoperative, and postoperative measures can be considered...
December 21, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28004126/the-hif-1-antagonist-acriflavine-visualization-in-retina-and-suppression-of-ocular-neovascularization
#7
Mingbing Zeng, Jikui Shen, Yuanyuan Liu, Lucy Yang Lu, Kun Ding, Seth D Fortmann, Mahmood Khan, Jiangxia Wang, Sean F Hackett, Gregg L Semenza, Peter A Campochiaro
: Acriflavine, a fluorescent drug previously used for bacterial and trypanosomal infections, reduces hypoxia-inducible factor-1 (HIF-1) and HIF-2 transcriptional activity. In mice with oxygen-induced ischemic retinopathy, intraocular or intraperitoneal injections of acriflavine caused dose-dependent suppression of retinal neovascularization (NV) and significantly reduced expression of HIF-1-responsive genes. Intraocular injection of 100 ng caused inner retina fluorescence within 1 h that was seen throughout the entire retina between 1 and 5 days, and at 7 days after injection, strongly suppressed choroidal NV at Bruch's membrane rupture sites...
December 21, 2016: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28003975/preoperative-evaluation-and-outcome-of-corneal-transplantation-for-limbal-dermoids-a-ten-year-follow-up-study
#8
Meng Xin, Yue-Rong Gong, Shan-Hao Jiang, Chun-Hua Dai, Su-Xia Li, Wei-Yun Shi
AIM: To summarize preoperative evaluation and outcome of corneal transplantation for limbal dermoids for ten years. METHODS: Eighty-five patients diagnosed with limbal dermoids and treated with corneal transplantation were analyzed retrospectively. All patients were further divided into two groups according to absence or presence of neovascularization surrounding the dermoids in the corneal stroma. Eighty-two eyes were treated with tumor excision combined with partial lamellar sclerokeratoplasty, and the other three eyes were performed by penetrating keratoplasty...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27998864/-role-of-stromal-cell-derived-factor-1-and-cxc-chemokine-receptor-4-in-corneal-graft-rejection-in-rats
#9
Xiao-Song Wu, Jing Wu, Ming Ma, Xiao-Li Lu, Jian Yu, Zhen-Yu Zhang
OBJECTIVE: To examine expression of stromal cell-derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) in rat cornea tissue and their role in corneal allograft rejection. METHODS: With 15 Wistar rats as the normal control group, 22 Wistar rats received autologous corneal graft transplantation, and 44 Wistar rats received transplantation of corneal graft from SD rats with penetrating keratoplasty. From the rats with allograft transplantation, 22 were selected randomly for treatment with TobraDex eye drops for 30 days after the operation (twice a day), and the remaining 22 rats were treated with normal saline only...
December 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27990354/effect-of-trapping-vascular-endothelial-growth-factor-a-in-a-murine-model-of-dry-eye-with-inflammatory-neovascularization
#10
Jin Woo Kwon, Jin A Choi, Eun Young Shin, Tae Yoon La, Dong Hyun Jee, Yeon Woong Chung, Yang Kyung Cho
AIM: To evaluate whether trapping vascular endothelial growth factor A (VEGF-A) would suppress angiogenesis and inflammation in dry eye corneas in a murine corneal suture model. METHODS: We established two groups of animals, one with non-dry eyes and the other with induced dry eyes. In both groups, a corneal suture model was used to induce inflammation and neovascularization. Each of two groups was again divided into three subgroups according to the treatment; subgroup I (aflibercept), subgroup II (dexamethasone) and subgroup III (phosphate buffered saline, PBS)...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27896297/a-mouse-model-of-multi-drug-resistant-staphylococcus-aureus-induced-ocular-disease
#11
Nicole M Broekema, Inna V Larsen, Erika S Naruzawa, Marcin Filutowicz, Aaron W Kolb, Leandro B C Teixeira, Curtis R Brandt
Staphylococcus aureus infection of the cornea is a significant threat to vision. The percentage of bacterial isolates resistant to antibiotics is increasing as is the percentage of infections caused by methicillin resistant isolates. There is a critical need for additional therapeutic approaches and their development will require the use of animal models to test efficacy. Two mouse models of S. aureus keratitis have been described but only quantified stromal keratitis (corneal clouding and perforation). We have extended these models using the methicillin resistant S...
November 2016: Journal of Ocular Biology
https://www.readbyqxmd.com/read/27882245/ocular-biocompatibility-of-poly-n-isopropylacrylamide-pnipam
#12
Luiz H Lima, Yael Morales, Thiago Cabral
Purpose. To study the safety of intravitreal injections of poly-N-isopropylacrylamide (pNIPAM) tissue adhesive in rabbit eyes. Methods. Twelve study rabbits received an intravitreal injection of 0.1 mL 50% pNIPAM in the right eye. Follow-up examinations included color fundus photography, fundus fluorescein angiography (FA), optical coherence tomography (OCT), and electroretinography (ERG). Subsequent to the last follow-up assessment, the rabbits were sacrificed and histopathological study on the scleral incision sites was performed...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27825105/mir-184-exhibits-angiostatic-properties-via-regulation-of-akt-and-vegf-signaling-pathways
#13
Jong Kook Park, Han Peng, Wending Yang, Julia Katsnelson, Olga Volpert, Robert M Lavker
Corneal avascularity is critical for achieving transparency necessary for proper transmission of light to the lens and visual acuity. Although much is known about angiogenesis and angiostasis, the precise regulation of these processes in the cornea is unclear. MicroRNA (miR)-184, the most abundant corneal epithelial miRNA, has been suggested to function in corneal angiostasis by altering VEGF signaling; however, the mechanism(s) underlying this regulation have not been addressed. Using a combination of in vitro and in vivo assays to evaluate angiogenesis, we demonstrated that human limbal epithelial keratinocytes (HLEKs) engineered to overexpress miR-184 secreted lower amounts of angiogenic mitogens...
January 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27766030/lacrimal-duct-occlusion-is-associated-with-infectious-keratitis
#14
Guigang Li, Jingmin Guo, Rong Liu, Weikun Hu, Lingjuan Xu, Juan Wang, Subo Cai, Hong Zhang, Yingting Zhu
Background: To explore the prevalence of lacrimal duct obstruction in patients with infectious keratitis, and the necessity of lacrimal duct dredge in the treatment of human infectious keratitis. Methodology/Principle Findings: The design is prospective, non-control case series. Thirty-one eyes from twenty-eight continuous patients with infectious keratitis were included in this study. The presence/absence of lacrimal duct obstruction was determined by the lacrimal duct irrigation test. The diagnosis of infectious keratitis was made based on clinical manifestations, cornea scraping microscopic examination and bacterial/fungus culture...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27742136/-limbal-stem-cell-deficiency-management-a-review
#15
REVIEW
V Kocaba, O Damour, C Auxenfans, C Burillon
Limbal stem cell deficiency is predominantly caused by severe eye burns resulting in a decreased or a complete ablation of the regenerative potential of these stem cells. The inability to reconstruct the corneal epithelium further leads conjunctivalization of the gimbal-epithelial barrier. These abnormalities collectively result in the progressive opacification of the cornea responsible for blindness that is driven by chronic corneal ulceration and neovascularization. The underlying pathology of the cornea affects the homeostasis of the neighboring conjunctiva, eyelids, and tear film...
November 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27724848/morphological-changes-in-the-meibomian-glands-of-patients-with-phlyctenular-keratitis-a-multicenter-cross-sectional-study
#16
Takashi Suzuki, Naoyuki Morishige, Reiko Arita, Shizuka Koh, Tohru Sakimoto, Rika Shirakawa, Kazunori Miyata, Yuichi Ohashi
BACKGROUND: Phlyctenular keratitis is a hypersensitivity reaction of the cornea, and a complication of eyelid margin disease in children and young adults. In this study, we compared the morphology of the meibomian glands in eyelids between phlyctenular keratitis patients and healthy young adults, using noncontact meibography. METHODS: The study included 16 eyes of 13 patients diagnosed with phlyctenular keratitis and 17 eyes of 17 healthy volunteers. Slit-lamp observations of the cornea and eyelid were performed on all subjects...
October 10, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27694752/nerve-growth-factor-facilitates-the-innervation-of-perivascular-nerves-in-tumor-derived-neovasculature-in-the-mouse-cornea
#17
Yoko Sone, Shingo Takatori, Eiko Ochi, Yoshito Zamami, Akiko Matsuyama, Satoko Fukuhara, Mitsuhiro Goda, Yoshihisa Kitamura, Hiromu Kawasaki
BACKGROUND: Tumor neovascular vessels are not innervated by perivascular nerves. This study was an investigation of the effects of the nerve growth factor (NGF) on the distribution of perivascular nerves and neovessel formation in tumor tissues. METHODS: A gel containing DU145 prostate carcinoma cells or HT1080 fibrosarcoma cells was implanted into mouse corneas. NGF was subcutaneously administered using an osmotic mini-pump. The distribution of perivascular nerves in mouse corneas and densities of CD31-immunopositive neovessels and smooth muscles (α-smooth muscle actin, α-SMA) in tumor tissues were quantified...
October 1, 2016: Pharmacology
https://www.readbyqxmd.com/read/27672587/attenuation-of-corneal-neovascularization-by-topical-low-molecular-weight-heparin-taurocholate-7-without-bleeding-complication
#18
Jae Yong Kim, Soo Yeon Kim, Mi Hyun Cheon, Eun-Soon Kim, In Seok Song, Myoung Joon Kim, Hungwon Tchah
AIM: To investigate the antiangiogenic effects and safety of topically administered low-molecular-weight heparin-taurocholate 7 (LHT7) on corneal neovascularization (CoNV). METHODS: Twenty-four Sprague-Dawley rats were randomly distributed into four groups of six rats each. The central corneas were cauterized using a silver/potassium nitrate solution. From 2d after cauterization, 12.5 mg/mL (low LHT7 group) or 25 mg/mL (high LHT7 group) LHT7 was topically administered three times daily; 12...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27651001/construction-of-a-corneal-stromal-equivalent-with-smile-derived-lenticules-and-fibrin-glue
#19
Houfa Yin, Peijin Qiu, Fang Wu, Wei Zhang, Wenqi Teng, Zhenwei Qin, Chao Li, Jiaojie Zhou, Zhi Fang, Qiaomei Tang, Qiuli Fu, Jian Ma, Yabo Yang
The scarcity of corneal tissue to treat deep corneal defects and corneal perforations remains a challenge. Currently, small incision lenticule extraction (SMILE)-derived lenticules appear to be a promising alternative for the treatment of these conditions. However, the thickness and toughness of a single piece of lenticule are limited. To overcome these limitations, we constructed a corneal stromal equivalent with SMILE-derived lenticules and fibrin glue. In vitro cell culture revealed that the corneal stromal equivalent could provide a suitable scaffold for the survival and proliferation of corneal epithelial cells, which formed a continuous pluristratified epithelium with the expression of characteristic markers...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27631351/two-photon-microscopy-of-the-mouse-peripheral-cornea-ex-vivo
#20
Jun Ho Lee, Ki Hean Kim, Seunghun Lee, Hyerin Jeong, Myoung Joon Kim
PURPOSE: To investigate the 3-dimensional (3D) cell and extracellular matrix (ECM) structure of mouse peripheral corneas in normal and corneal neovascularization tissues using 2-photon microscopy (TPM) based on both intrinsic and extrinsic moxifloxacin contrasts. METHODS: Peripheral corneas in freshly enucleated mouse eyes were imaged by TPM based on both intrinsic and extrinsic contrasts. Intrinsic autofluorescence and second harmonic generation were used to image cells and ECM collagen, respectively...
November 2016: Cornea
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