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https://www.readbyqxmd.com/read/28427301/corneal-endothelial-changes-in-long-term-cannabinoid-users
#1
Nihat Polat, Birgul Cumurcu, Tongabay Cumurcu, İlknur Tuncer
PURPOSE: The aim of this study was to evaluate the effects of long-term cannabis use on the corneal endothelial cells with the specular microscopy. METHODS: The study enrolled 28 eyes of 28 patients diagnosed with cannabinoid use disorder. The cannabinoid group was selected among patients who had been using the substance for 3 days or more per week over the past 1 year. 32 eyes of 32 age- and sex-matched healthy individuals enrolled as control group in the study...
April 20, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28380096/visual-rehabilitation-using-mini-scleral-contact-lenses-after-penetrating-keratoplasty
#2
Guilherme Andrade do Nascimento Rocha, Patrícia Oliveira Braga Miziara, Ana Clara Vieira de Castro, Arthur Andrade do Nascimento Rocha
Purpose: To report the visual rehabilitation outcomes and complications of patients fitted with mini-scleral rigid gas-permeable (RGP) contact lenses (mini-SCLs) after penetrating keratoplasty. Methods: We retrospectively reviewed 27 eyes (21 patients) that were fitted with mini-SCLs between October 2013 and December 2014. We analyzed demographic data, previous corneal disorders, visual outcomes, interval from keratoplasty to contact lens fitting, topographic and specular microscope data, fitted contact lens parameters, and complications...
January 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28374155/morphometry-of-organ-cultured-corneal-endothelium-using-voronoi-segmentation
#3
Nigel H Brookes
The endothelial viability of eye-banked corneas must be assessed before transplantation, yet phase-contrast images of the endothelium of corneas stored in an Organ Culture system have a huge variety of endothelial appearance at different focal planes, due to stromal swelling and an evaluation technique that swells the cells and their intercellular spaces to make them visible. This makes them difficult to assess using common edge-based segmentation methodologies that have mostly been developed in vivo using specular microscopy...
April 3, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28368996/evaluation-of-angle-closure-as-a-risk-factor-for-reduced-corneal-endothelial-cell-density
#4
Varshini Varadaraj, Sabyasachi Sengupta, Krishnamurthy Palaniswamy, Kavitha Srinivasan, Mohideen A Kader, Ganesh Raman, Sharmila Reddy, Pradeep Y Ramulu, Rengaraj Venkatesh
PURPOSE: Acute angle closure attacks are frequently accompanied by corneal edema. However, little is known about corneal endothelial cell status at different stages of angle closure. Here, we compared endothelial cell density (ECD) in unoperated eyes with that in eyes with open angles (OAs) and various stages of angle closure disease. MATERIALS AND METHODS: The study was conducted at Aravind Eye Hospitals in India. Masked examiners performed gonioscopy to classify each eye as follows: (1) OA, (2) primary angle closure suspect, or (3) primary angle closure (PAC)/primary angle closure glaucoma (PACG)...
March 31, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28362786/dark-field-brillouin-microscopy
#5
Giuseppe Antonacci
Brillouin microscopy is a non-contact and label-free technique for mapping fundamental micro-mechanical properties in the volume of biological systems. Specular reflections and elastic scattering easily overwhelm the weak Brillouin spectra due to the limited extinction of virtually imaged phased array spectrometers, thereby affecting the image acquisition. In this Letter, a dark-field method was demonstrated to reject the elastic background light using an annular illumination and a confocal detection. To validate the method, images of polystyrene and liquid samples were obtained using both a confocal and the dark-field system...
April 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28346276/comparison-of-noncontact-specular-and-confocal-microscopy-for-evaluation-of-corneal-endothelium
#6
Jianyan Huang, Jyotsna Maram, Tudor C Tepelus, Srinivas R Sadda, Vikas Chopra, Olivia L Lee
PURPOSE: To compare endothelial cell analysis obtained by noncontact specular and confocal microscopy, using the Konan NSP-9900 and Nidek ConfoScan4 systems, respectively. METHODS: Three groups including 70 healthy eyes, 49 eyes with Fuchs endothelial corneal dystrophy (FECD), and 78 eyes with glaucoma were examined with both the Konan NSP-9900 specular microscope and the Nidek ConfocScan4 confocal microscope. Certified graders at the Doheny Image Reading Center compared corneal endothelial images from both instruments side by side to assess image quality...
March 24, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28306601/assessing-the-impact-of-diabetes-mellitus-on-donor-corneal-endothelial-cell-density
#7
Chase A Liaboe, Benjamin T Aldrich, Pamela C Carter, Jessica M Skeie, Kimberlee A Burckart, Gregory A Schmidt, Cynthia R Reed, M Bridget Zimmerman, Mark A Greiner
PURPOSE: To quantify changes in endothelial cell density (ECD) of donor corneal tissue in relation to the presence or absence of a medical history of diabetes mellitus diagnosis, treatment, and complications. METHODS: A retrospective review was performed for all corneas collected at Iowa Lions Eye Bank between January 2012 and December 2015. For purposes of analysis, donor corneas were divided into 4 groups: nondiabetic, non-insulin-dependent diabetic, insulin-dependent diabetic without medical complications due to diabetes, and insulin-dependent diabetic with medical complications due to diabetes...
May 2017: Cornea
https://www.readbyqxmd.com/read/28280298/corneal-endothelium-and-central-corneal-thickness-changes-in-type-2-diabetes-mellitus
#8
Amira El-Agamy, Shams Alsubaie
PURPOSE: This study was conducted to compare the corneal endothelial cell density (ECD), morphological features, and central corneal thickness (CCT) in type 2 diabetes mellitus (DM) with age-matched, nondiabetic control subjects using EM-3000 Specular Microscope. STUDY DESIGN: This was a prospective, hospital-based, nonrandomized, case-control, observational, and quantitative study. SUBJECTS AND METHODS: The study included 57 patients (57 eyes) with type 2 DM and 45 control (nondiabetic) subjects (45 eyes)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28268563/automated-morphometric-description-of-human-corneal-endothelium-from-in-vivo-specular-and-confocal-microscopy
#9
F Scarpa, A Ruggeri
Corneal images acquired by in-vivo specular and confocal microscopy provide clinical information on the cornea endothelium health state. Indeed, the normal hexagonal shape of endothelial cells is usually affected by age and pathologies. At present, the analysis is based on manual or semi-automatic methods and the segmentation of a large number of endothelial cells is required for a meaningful estimation of the clinical parameters. We propose an automated method that detects the centers of endothelial cells by convolving the original image with customized two-dimensional kernels, derives a structure made by connected vertices from the recognized centers using the Euclidean distance, and fine-tunes the derived structure through a genetic algorithm, which combines information about the typical regularity of endothelial cells shape with the pixels intensity of the actual image...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28254359/accuracy-of-cirrus-hd-oct-and-topcon-sp-3000p-for-measuring-central-corneal-thickness
#10
Jorge A Calvo-Sanz, Javier Ruiz-Alcocer, Miguel A Sánchez-Tena
PURPOSE: To compare and analyze the interchangeability of three measuring systems, each based on a different technique, for central corneal thickness (CCT) analysis. METHODS: CCT measurements were measured using optical coherence tomography (OCT), non-contact specular microscopy (NCSM), and ultrasonic pachymetry (USP) in 60 eyes of 60 healthy patients with a mean age of 66.5±15.0 years and a mean spherical equivalent of 0.43±1.14 D. Analysis of variations in measurement concordance and correlation among the three different methods were performed...
February 18, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/28244295/safety-of-using-matrix-metalloproteinase-inhibitor-in-experimental-glaucoma-filtration-surgery
#11
Wool Suh, Kyung Eun Han, Jae Ryong Han
We evaluated the safety of matrix metalloproteinase (MMP) inhibitor in experimental glaucoma filtration surgery in an animal model. Fifteen New Zealand white rabbits underwent an experimental trabeculectomy and were randomly allocated into 3 groups according to the adjuvant agent: no treatment group (n = 5), 0.02% mitomycin C (MMC) soaking group (n = 5), and MMP inhibitor (ilomastat) subconjunctival injection group (n = 5). Slit lamp examination with Seidel testing, pachymetry, and specular microscopy was performed preoperatively and postoperatively...
April 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28239829/comparison-of-anterior-segment-parameter-values-obtained-with-scheimpflug-placido-topographer-optical-low-coherence-reflectometry-and-noncontact-specular-microscopy-in-morbid-obesity
#12
B Dogan, U Dogan, M K Erol, M Habibi, M T Oruc
OBJECTIVE: To investigate the measurement of anterior segment parameters using Sirius Scheimpflug-Placido topographer, Lenstar optical low coherence reflectometry (OLCR), and noncontact specular microscopy (SM) in morbidly obese and nonobese subjects. PATIENTS AND METHODS: Twenty-eight morbidly obese subjects (BMI ≥ 40; Group 1) and 28 age- sex-matched healthy nonobese subjects (BMI 18.50-24.99; Group 2) were included in this study. Anterior segment parameters were measured by Scheimpflug-Placido topographer and OLCR...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28237147/corneal-endothelial-cell-loss-after-pars-plana-vitrectomy-and-combined-phacoemulsification-vitrectomy-surgeries
#13
Keyvan Koushan, Mikel Mikhail, Anne Beattie, Nina Ahuja, Allan Liszauer, Lawrence Kobetz, Forough Farrokhyar, James A Martin
OBJECTIVE: To compare postoperative corneal endothelial cell density (ECD) loss in eyes undergoing pars plana vitrectomy (PPV), or combination of cataract extraction (using phacoemulsification) and intraocular lens implantation with vitrectomy (CE/IOL-PPV) surgeries. METHODS: Institutional setting. Best-corrected visual acuity (BCVA) and ECD by specular microscopy were measured preoperatively and 3 months postoperatively in both groups. Relative postoperative ECD loss was the primary outcome measure...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28226740/automated-morphometric-description-of-human-corneal-endothelium-from-in-vivo-specular-and-confocal-microscopy
#14
F Scarpa, A Ruggeri, F Scarpa, A Ruggeri, A Ruggeri, F Scarpa
Corneal images acquired by in-vivo specular and confocal microscopy provide clinical information on the cornea endothelium health state. Indeed, the normal hexagonal shape of endothelial cells is usually affected by age and pathologies. At present, the analysis is based on manual or semi-automatic methods and the segmentation of a large number of endothelial cells is required for a meaningful estimation of the clinical parameters. We propose an automated method that detects the centers of endothelial cells by convolving the original image with customized two-dimensional kernels, derives a structure made by connected vertices from the recognized centers using the Euclidean distance, and fine-tunes the derived structure through a genetic algorithm, which combines information about the typical regularity of endothelial cells shape with the pixels intensity of the actual image...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28129302/evaluation-and-quality-assessment-of-prestripped-preloaded-descemet-membrane-endothelial-keratoplasty-grafts
#15
Khoa D Tran, Philip K Dye, Kelly Odell, Joshua Galloway, Christopher G Stoeger, Michael D Straiko, Mark A Terry
PURPOSE: To determine graft quality and feasibility of Descemet membrane endothelial keratoplasty (DMEK) grafts that are prestripped and preloaded into injectors by eye bank technicians before shipping to surgeons. METHODS: DMEK grafts (n = 31) were prepared from donor corneas and preloaded into Straiko Modified Jones tubes and set inside viewing chambers filled with 20 mL of Optisol-GS. Preloaded grafts were evaluated using specular microscopy and slit-lamp biomicroscopy...
January 26, 2017: Cornea
https://www.readbyqxmd.com/read/28114585/immune-cells-on-the-corneal-endothelium-of-an-allogeneic-corneal-transplantation-rabbit-model
#16
Elena Koudouna, Naoki Okumura, Yugo Okazaki, Shinichiro Nakano, Ryota Inoue, Nigel J Fullwood, Junko Hori, Shigeru Kinoshita, Noriko Koizumi
Purpose: Corneal endothelial cell density undergoes a progressive decrease for many years after transplantation, eventually threatening patients with late endothelial failure. The purpose of this study was to investigate the possibility of an immunologic response in successfully grafted corneal endothelium. Methods: The corneal endothelium of patients who had undergone corneal transplantation was evaluated by specular microscopy. Rabbit models were subjected to penetrating keratoplasty (PK) with either syngeneic or allogeneic corneal transplants and Descemet's stripping endothelial keratoplasty (DSEK) with allogeneic corneal transplants...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28060145/corneal-endothelial-cell-density-and-morphology-in-different-trimesters-of-pregnancy
#17
Nurgül Örnek, Zeynep Özcan Dağ, Kemal Örnek
OBJECTIVES: To evaluate corneal endothelial cell density (CD) and morphology in different trimesters of pregnancy. METHODS: This prospective study included 66 (66 eyes) pregnant women. The patient group was divided into three subgroups comprised of 22 women in the first, second, and third trimesters of pregnancy. An age-matched group of 22 (22 eyes) volunteers served as controls. Corneal measurements were performed using specular microscopy (Noncon Robo SP8000, Konan Medical)...
January 4, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28060074/eventual-endothelial-failure-after-initial-corneal-clearing-after-a-detached-endothelial-graft-in-fuchs-dystrophy
#18
Hyunjoo J Lee, Wuqaas M Munir
PURPOSE: To report a case of eventual corneal endothelial cell failure after spontaneous resolution of corneal edema after failed Descemet membrane endothelial keratoplasty (DMEK). METHODS: Retrospective case report. RESULTS: A 56-year-old man with Fuchs endothelial corneal dystrophy underwent cataract and DMEK surgery in the left eye. The transplanted DMEK graft detached in the early postoperative period and formed a peripheral scroll. Despite graft detachment, corneal edema resolved with endothelial cell repopulation of the central cornea...
February 2017: Cornea
https://www.readbyqxmd.com/read/28060070/enhancing-dmek-success-by-identifying-optimal-levels-of-trypan-blue-dye-application-to-donor-corneal-tissue
#19
Parag A Majmudar, Lauren Johnson
PURPOSE: The purpose of this study was to determine the correct concentration and duration of application of trypan blue dye to Descemet membrane endothelial keratoplasty (DMEK) donor corneal tissue before transplant to enhance visibility while minimizing damage to the tissue. METHODS: Corneas were precut for DMEK using an 8-mm punch, and each was stained with either 0.06% or 0.15% trypan blue for a duration of 1, 3, or 5 minutes. After staining, each tissue was placed in balanced salt solution and observed to determine how quickly the stain faded from the tissue using a grading system...
February 2017: Cornea
https://www.readbyqxmd.com/read/28060061/conventional-and-iontophoresis-corneal-cross-linking-for-keratoconus-efficacy-and-assessment-by-optical-coherence-tomography-and-confocal-microscopy
#20
Léa Jouve, Vincent Borderie, Otman Sandali, Cyrille Temstet, Elena Basli, Laurent Laroche, Nacim Bouheraoua
PURPOSE: To compare the efficacy, safety, and microstructural corneal changes during 2 years after conventional corneal collagen cross-linking (C-CXL) and transepithelial corneal CXL by iontophoresis (I-CXL) for keratoconus. METHODS: Eighty eyes of 80 patients with progressive keratoconus were treated by C-CXL (n = 40) or I-CXL (n = 40). Patients were investigated before surgery and 1, 3, 6, 12, and 24 months after treatment. We measured central corneal thickness and maximal simulated keratometry values (Kmax) and performed specular microscopy and in vivo confocal microscopy at each time point...
February 2017: Cornea
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