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https://www.readbyqxmd.com/read/27910127/treatment-of-severe-chronic-hand-eczema-results-from-a-uk-wide-survey
#1
I L Smith, S Brown, J Nixon, F C Cowdell, S Ersser, C Fernandez, M Goodfield, C M Green, P Hampton, J T Lear, C H Smith, L Sunderland, S Tubeuf, M Wittmann
Treatment of severe hand eczema (HE) that is resistant to topical potent corticosteroid treatment is challenging. In 2013, we surveyed 194 UK dermatologists to obtain information about their usual treatment pathways to inform the choice of the comparator in a trial of alitretinoin in severe HE (ALPHA trial); the results indicated that the treatment approaches favoured by UK dermatologists differ. Psoralen combined with ultraviolet A (PUVA) and alitretinoin were identified as the most frequent first-line treatment options for hyperkeratotic HE, whereas oral corticosteroids were identified as the most frequent first-line treatment for vesicular HE, followed by PUVA and alitretinoin...
December 2, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27747960/clinical-and-microscopic-features-of-generalized-discoid-lupus-erythematosus-in-dogs-10-cases
#2
Frane Banovic, Keith E Linder, Maarja Uri, Michael A Rossi, Thierry Olivry
BACKGROUND: Generalized discoid lupus erythematosus (GDLE) is a newly recognized canine variant of chronic cutaneous lupus erythematosus (CLE) that is not well characterized. HYPOTHESIS/OBJECTIVES: We report herein the signalment, clinical signs, treatment outcome, histopathology and immunological findings of 10 dogs with GDLE. METHODS: Inclusion criteria were: (i) a >3 month history of generalized skin lesions indicating a chronic or recurrent nature; (ii) skin lesions resembling those of human GDLE; (iii) histopathology of CLE (lymphocyte-rich interface dermatitis)...
December 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/27547965/what-is-the-evidence-base-for-atopic-eczema-treatments-a-summary-of-published-randomised-controlled-trials
#3
H Nankervis, K S Thomas, F M Delamere, S Barbarot, S Smith, N K Rogers, H C Williams
Atopic eczema (AE) is a common chronic inflammatory skin condition. Whilst many AE treatment options are available, the evidence to support their efficacy varies in depth and quality. In 2000, an NIHR HTA systematic review identified and evaluated existing randomised controlled trials (RCTs) of AE treatments. To ensure continuing utility, the NIHR commissioned an update to the review. Here, we present an overview of the updated report and key findings. Systematic reviews and RCTs of AE treatments that included participants with AE (criteria based or diagnosed) were identified using: MEDLINE, EMBASE, CENTRAL, LILACS, AMED, CINAHL and Cochrane Skin Group Specialised Register (searched to August 31(st) 2013 (RCTs) and 31(st) December 2015 (systematic reviews))...
August 22, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27519560/incidence-and-risk-factors-of-elevated-intraocular-pressure-following-deep-anterior-lamellar-keratoplasty
#4
Olivia S Huang, Jodhbir S Mehta, Hla M Htoon, Donald T Tan, Tina T Wong
PURPOSE: To report the incidence and risk factors of elevated IOP following deep anterior lamellar keratoplasty (DALK). DESIGN: A retrospective case series. METHODS: A retrospective study investigating the 5-year incidence of raised IOP following DALK cases performed from 2004 to 2008 in a tertiary center. Patients with less than 6 months of follow-up were excluded. Elevated IOP was defined as IOP >21 mm Hg. RESULTS: An episode of elevated IOP occurred in 36...
October 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27450147/management-of-severe-and-refractory-mooren-s-ulcers-with-rituximab
#5
Damien Guindolet, Clotilde Reynaud, Gaelle Clavel, Georges Belangé, Maycene Benmahmed, Serge Doan, Gilles Hayem, Isabelle Cochereau, Eric E Gabison
PURPOSE: Management of severe and refractory Mooren's ulcers is challenging as it encompasses tectonic surgical treatment and aggressive immunosuppressive therapies. Efficacy of rituximab in the management of severe Mooren's ulcers has never been reported. METHODS: Five patients (six eyes) from the Cornea and External Disorders department at the Rothschild Ophthalmologic Foundation (Paris, France) were treated for severe Mooren's ulcer unresponsive to conventional treatments between 2008 and 2016...
July 22, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27141648/-how-i-treat-psoriasis-using-step-procedures
#6
C Piérard-Franchimont, G E Piérard
Psoriasis is a multifactorial disease characterized by a cutaneous involvement possibly associated with various comorbidities. The disease associates some qualitative abnormal epidermal proliferation and immune alterations expressed by the presence of a dermal inflammatory infiltrate with neutrophil exocytosis. The hereditary aspect is well-documented and various susceptibility loci have been described on several chromosomes. The treatment relies on an eventual identifiable cause, and on the severity of the cutaneous involvement, as well as the presence of various comorbidities...
February 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/26997607/-topical-cyclosporine-in-ophthalmology-pharmacology-and-clinical-indications
#7
REVIEW
O Levy, A Labbé, V Borderie, L Laroche, N Bouheraoua
Cyclosporine A (CsA) is a cyclic undecapeptide, which is an immunosuppressive drug in the calcineurin inhibitor class. CsA was initially used as a systemic immunosuppressant to minimize rejection of solid organ transplants. In ophthalmology, topically applied CsA was first used to inhibit corneal allograft rejection in the 1980s and later in various inflammatory ocular surface disorders (OSD). Currently, topical ophthalmic CsA is available as a licensed commercial emulsion or is prepared by hospital pharmacies with concentration ranging from 0...
March 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/26833520/atopic-eczema
#8
Sara J Brown
Atopic eczema is an itchy inflammatory skin disease with a chronic relapsing-remitting course; it has increased in prevalence in recent decades and now affects up to 25% of school-aged children in the developed world and up to 10% of adults. Recent advances in understanding the aetiology of eczema have focused interest on skin barrier dysfunction as a common precursor and pathological feature. In addition, genetically determined skin barrier dysfunction (associated with mutations in the gene encoding filaggrin) is known to predispose to multiple systemic atopic diseases...
February 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/26823393/long-term-outcome-after-topical-ciclosporin-in-severe-dry-eye-disease-with-a-10-year-follow-up
#9
Morgane Straub, Alain M Bron, Aurore Muselier-Mathieu, Catherine Creuzot-Garcher
AIM: To report a 10-year follow-up of patients suffering from severe dry eye syndrome (DES) initially treated with topical ciclosporin A (tCSA) for 6 months. METHODS: The charts of 26 patients with severe DES related to keratoconjunctivitis sicca (KCS) and followed for a minimum 10-year follow-up were retrospectively reviewed. All of them were treated initially with tCSA for 6 months. The Schirmer I test, fluorescein and lissamine green staining scores and tear film break-up time (TBUT) were recorded to assess clinical symptoms before, during and after treatment...
January 28, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/26707941/sebaceous-adenitis-and-mural-folliculitis-in-a-cat-responsive-to-topical-fatty-acid-supplementation
#10
Katharina Glos, Wolf von Bomhard, Sonya Bettenay, Ralf S Mueller
OBJECTIVE: To describe a case of feline sebaceous adenitis and mural folliculitis, and its successful treatment with topical fatty acids. ANIMAL: A 5-year-old, male castrated Norwegian Forest cat was presented with a progressive seborrhoeic dermatitis. METHODS: Clinical examination and histopathological examination of skin biopsies. RESULTS: There was severe, multifocal, lymphocytic mural folliculitis and perifollicular dermatitis, moderate hyperkeratosis and sebaceous adenitis on histopathology...
February 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/26586215/an-update-on-the-treatment-of-canine-atopic-dermatitis
#11
REVIEW
Manolis N Saridomichelakis, Thierry Olivry
Canine atopic dermatitis is a common skin disease seen in veterinary clinical practice. Several factors appear to contribute to the cutaneous inflammation and pruritus. The therapeutic strategy should focus on control of those factors that can be identified and for which interventional measures are feasible; these include ectoparasites, bacterial/fungal infection and dietary hypersensitivity. Ectoparasites, particularly fleas, are not the cause of atopic dermatitis, but they are a confounding factor, which can exacerbate pruritus, and preventative measures are therefore indicated...
January 2016: Veterinary Journal
https://www.readbyqxmd.com/read/26276051/treatment-of-canine-atopic-dermatitis-2015-updated-guidelines-from-the-international-committee-on-allergic-diseases-of-animals-icada
#12
Thierry Olivry, Douglas J DeBoer, Claude Favrot, Hilary A Jackson, Ralf S Mueller, Tim Nuttall, Pascal Prélaud
BACKGROUND: In 2010, the International Task Force on Canine Atopic Dermatitis (now International Committee on Allergic Diseases of Animals, ICADA) published the first consensus guidelines for the treatment of atopic dermatitis (AD) in dogs. This is the first 5-year minor update of this document. RESULTS: The treatment of acute flares of AD should involve the search for, and then elimination of, the cause of the flares, bathing with mild shampoos, and controlling pruritus and skin lesions with interventions that include topical and/or oral glucocorticoids or oclacitinib...
2015: BMC Veterinary Research
https://www.readbyqxmd.com/read/26131750/-a-woman-with-painful-ulcera-on-her-lower-leg
#13
Ramon-Michel Schreuder, Barbara Horváth, Hendrik M van Dullemen
A 49-year-old woman presented with painful ulcera on her right lower leg. She was known with Crohn's disease. Wound cultures were negative. Based on clinical findings she was diagnosed with pyoderma gangrenosum. After treatment with topical glucocorticoids and intravenous infliximab and ciclosporin, the ulcera gradually disappeared.
2015: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/25919144/interventions-for-rosacea
#14
REVIEW
Esther J van Zuuren, Zbys Fedorowicz, Ben Carter, Mireille M D van der Linden, Lyn Charland
BACKGROUND: Rosacea is a common chronic skin condition affecting the face, characterised by flushing, redness, pimples, pustules and dilated blood vessels. The eyes are often involved and thickening of the skin with enlargement (phymas), especially of the nose, can occur in some people. A range of treatment options are available but it is unclear which are most effective. OBJECTIVES: To assess the efficacy and safety of treatments for rosacea. SEARCH METHODS: We updated our searches, to July 2014, of: the Cochrane Skin Group Specialised Register, CENTRAL in The Cochrane Library (2014, Issue 6), MEDLINE (from 1946), EMBASE (from 1974) and Science Citation Index (from 1988)...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25278258/targeted-cutaneous-delivery-of-ciclosporin-a-using-micellar-nanocarriers-and-the-possible-role-of-inter-cluster-regions-as-molecular-transport-pathways
#15
Maria Lapteva, Verena Santer, Karine Mondon, Ilias Patmanidis, Gianpaolo Chiriano, Leonardo Scapozza, Robert Gurny, Michael Möller, Yogeshvar N Kalia
Oral administration of ciclosporin A (CsA) is indicated in the treatment of severe recalcitrant plaque psoriasis. However, CsA is both nephro- and hepatotoxic and its systemic administration also exposes the patient to other severe side effects. Although topical delivery of CsA, targeted directly to psoriatic skin, would offer significant advantages, there are no topical formulations approved for dermatological use. The aim of this work was to formulate CsA loaded polymeric micelles using the biodegradable and biocompatible MPEG-dihexPLA diblock copolymer and to evaluate their potential for delivering the drug selectively into the skin without concomitant transdermal permeation...
December 28, 2014: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/24985558/treatment-for-palmoplantar-pustular-psoriasis-systematic-literature-review-evidence-based-recommendations-and-expert-opinion
#16
REVIEW
M Sevrain, M-A Richard, T Barnetche, M Rouzaud, A P Villani, C Paul, M Beylot-Barry, D Jullien, S Aractingi, F Aubin, P Joly, M Le Maitre, A Cantagrel, J-P Ortonne, L Misery
BACKGROUND: Palmoplantar pustular psoriasis (PPPP) is a variant of psoriasis whose the association with psoriatic arthritis (PsA) has been recently described. There is limited evidence regarding how to best reduce palmoplantar pustular psoriasis severity and to maintain remission once achieved. OBJECTIVE: The aim of this study was to elaborate evidence-based recommendations for PPPP treatment supported by a systematic literature review. METHODS: A systematic literature search was carried out in Embase, Medline and Cochrane Library databases from 1980 to February 2013 searching for any trial in patients with PPPP assessing therapeutic interventions not including a systemic biotherapy...
August 2014: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/24964946/management-of-moderate-to-severe-plaque-psoriasis-in-pregnancy-and-lactation-in-the-era-of-biologics
#17
Liljana Mervic
Psoriasis is not uncommon in the reproductive years and therefore in pregnant patients. There are limited data about the impact of psoriasis on the course and prognosis of pregnancy and about the impact of pregnancy on the course of psoriasis. Usually the disease improves during pregnancy and patients experience worsening between 4 and 6 weeks after delivery. A safe option for patients with limited disease is topical therapy, including moisturizers and topical steroids as well as UVB phototherapy. In the case of active psoriasis or even psoriasis worsening during pregnancy, there might be a need for continuation or even introduction of systemic therapy...
2014: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/24914693/the-eye-a-window-of-opportunity-in-rheumatoid-arthritis
#18
REVIEW
Louis Tong, Julian Thumboo, York Kiat Tan, Tien-Yin Wong, Salvatore Albani
Rheumatoid arthritis (RA), the most common autoimmune disorder associated with dry eye syndrome, is also associated with sight-threatening ocular diseases such as peripheral ulcerative keratitis, scleritis and corneal melts. Tissue damage on the ocular surface of patients with RA is autoimmune-mediated. Findings from patients with dry eye have implicated defects in innate immunity (Toll-like receptors, S100A and resident antigen-presenting cells), cytokines, chemokines and T helper (TH)-cell subsets (including TH1 and TH17) in disease pathogenesis...
September 2014: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/24912791/management-of-pyoderma-gangrenosum
#19
Alexandra Teagle, Rachel Hargest
Pyoderma gangrenosum (PG) is an uncommon ulcerative skin disease often associated with underlying systemic diseases. Its pathogenesis is unknown, although immune pathways have been implicated. Targeted therapy is therefore lacking and currently treatment is largely empirical and consists of corticosteroids and ciclosporin first line. This paper reviews the current and emerging knowledge about PG. PG occurs with an incidence of 3-10 per million per year. The ulcers are exquisitely painful and characteristically have a necrotic centre with irregular overhanging bluish borders...
June 2014: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/24811606/an-update-on-current-pharmacotherapy-options-in-atopic-dermatitis
#20
REVIEW
Sakari Reitamo, Anita Remitz
INTRODUCTION: New knowledge on the pathogenesis of atopic dermatitis (AD) gives us new treatment options. This review emphasizes long-term treatment results. AREAS COVERED: This study includes basic pathogenic factors in AD and presents present and future treatment options. Topical corticosteroids treat the inflammation effectively short term. Topical calcineurin inhibitors (TCIs) show better benefit/risk ratio in long-term treatment. For topical treatment, an effective maintenance treatment results in optimal control of the AD...
August 2014: Expert Opinion on Pharmacotherapy
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