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https://www.readbyqxmd.com/read/28216625/endothelial-overexpression-of-endothelin-1-modulates-aortic-carotid-iliac-and-renal-arterial-responses-in-obese-mice
#1
Oliver Baretella, Sookja K Chung, Aimin Xu, Paul M Vanhoutte
Endothelin-1 (ET-1) is essential for mammalian development and life, but it has also been implicated in increased cardiovascular risk under pathophysiological conditions. The aim of this study was to determine the impact of endothelial overexpression of the prepro-endothelin-1 gene on endothelium-dependent and endothelium-independent responses in the conduit and renal arteries of lean and obese mice. Obesity was induced by high-fat-diet (HFD) consumption in mice with Tie-1 promoter-driven, endothelium-specific overexpression of the prepro-endothelin-1 gene (TET(het)) and in wild-type (WT) littermates on a C57BL/6N background...
February 20, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28208456/nonequilibrium-steady-states-in-a-closed-inhomogeneous-asymmetric-exclusion-process-with-generic-particle-nonconservation
#2
Bijoy Daga, Souvik Mondal, Anjan Kumar Chandra, Tirthankar Banerjee, Abhik Basu
We study the totally asymmetric exclusion process (TASEP) on a nonuniform one-dimensional ring consisting of two segments having unequal hopping rates, or defects. We allow weak particle nonconservation via Langmuir kinetics (LK), which are parametrized by generic unequal attachment and detachment rates. For an extended defect, in the thermodynamic limit the system generically displays inhomogeneous density profiles in the steady state-the faster segment is either in a phase with spatially varying density having no density discontinuity, or a phase with a discontinuous density changes...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28203419/diagnosis-of-mitral-valve-cleft-using-real-time-3-dimensional-echocardiography
#3
Xinchun Yuan, Aiyun Zhou, Li Chen, Cheng Zhang, Yan Zhang, Pan Xu
BACKGROUND: Mitral valve cleft (MVC) is the most common cause of congenital mitral insufficiency, and MVC may occur alone or in association with other congenital heart lesions. Direct suture and valvuloplasty are the major and effective treatments for mitral regurgitation (MR) caused by MVC. Therefore, it is important to determine the location and magnitude of the pathological damage due to MVC when selecting a surgical procedure for treatment. This study explored the application value of transthoracic real-time 3-dimensional (3D) echocardiography (RT-3DE) in the diagnosis of MVC...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28193213/a-case-report-of-spontaneous-umbilical-enterocutaneous-fistula-resulting-from-an-incarcerated-richter-s-hernia-with-a-brief-literature-review
#4
Wei Chen, Lei Liu, Hui Huang, Mianxu Jiang, Tao Zhang
BACKGROUND: Richter's hernia is a high-risk ischaemic gastrointestinal disorder that is typically diagnosed in a delayed manner due to a lack of obvious symptoms. Spontaneous umbilical enterocutaneous fistula (ECF) resulting from an incarcerated Richter's hernia is extremely rare. CASE PRESENTATION: A 62-year-old female presented with a chief complaint of recurrent umbilical region infection for the preceding 20 months with no symptoms of ileus. Preoperative CT and fistulography revealed an incarcerated Richter's hernia complicated by an ECF...
February 13, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28192590/tomographic-findings-after-implantation-of-ferrara-intrastromal-corneal-ring-segments-in-keratoconus
#5
João Marcelo Lyra, Daniela Lyra, Guilherme Ribeiro, Leonardo Torquetti, Paulo Ferrara, Aydano Machado
PURPOSE: To analyze and compare changes to the anterior and posterior corneal surfaces after Ferrara intracorneal ring segment (ICRS) (AJL, Boecillo, Spain) implantation and to correlate those changes with visual outcomes. METHODS: This retrospective case series study comprised consecutive patients with keratoconus implanted with the Ferrara ICRS. Computed tomography scans of the two corneal surfaces were obtained preoperatively and postoperatively with a rotating Scheimpflug imaging system...
February 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28187474/new-mitral-annuloplasty-ring-enables-oversizing-of-transcatheter-heart-valve-and-prevents-central-or-paravalvular-leakage
#6
Georg Daniel Duerr, Jan-Malte Sinning, Armin Georg Welz, Fritz Mellert
Background Transcatheter valve-in-ring strategies have been developed to treat recurrent mitral regurgitation (MR) after failing surgical annuloplasty. However, suboptimal THV expansion with consecutive paravalvular leakage (PVL) is a procedure-immanent issue. Methods A rigid, saddle-shaped ring was cut at four locations. The segments were reconnected with pull-springs, rearranged to the original shape, and covered with a sewing cuff. The length of the annuloplasty ring construct, including extended pull-springs, was defined by the perimeter of an appropriate THV...
February 10, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28186217/time-and-space-resolved-study-of-the-methanol-to-hydrocarbons-mth-reaction-influence-of-zeolite-topology-on-axial-deactivation-patterns
#7
Daniel Rojo-Gama, Samaneh Etemadi, Eliot Kirby, Karl Petter Lillerud, Pablo Beato, Stian Svelle, Unni Olsbye
Zeolites representing seven different topologies were subjected to life-time assessment studies as methanol to hydrocarbons (MTH) catalysts at 400 °C, P(MeOH) = 13 kPa and P(tot) = 100 kPa. The following topologies were studied: ZSM-22 (TON), ZSM-23 (MTT), IM-5 (IMF), ITQ-13 (ITH), ZSM-5 (MFI), mordenite (MOR) and beta (BEA). Two experimental approaches were used. In the first approach, each catalyst was tested at three different contact times, all giving 100% initial conversion. The life-time before conversion decreased to 50% at each contact time was measured and used to calculate critical contact times (i...
February 10, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28184221/identification-of-key-residues-in-the-nisk-sensor-region-for-nisin-biosynthesis-regulation
#8
Xiaoxuan Ge, Kunling Teng, Jian Wang, Fangyuan Zhao, Jie Zhang, Jin Zhong
Histidine kinase (HK) NisK is well known to sense lantibiotic nisin for regulating the biosynthesis of nisin. NisK possesses two trans-membrane segments and a large extracellular region and nisin contains 34 amino acids with five lanthionine rings. Unlike most peptide sensing HK with multi trans-membrane segments, NisK is a representative of a group of rarely reported HK that sense peptide as ligand. To reveal how NisK senses nisin molecule to regulate nisin biosynthesis, we constructed a reporter Lactococcus lactis strain with nisRK constitutively expressed and a reporter gene lacZ expressed under the control of promoter P nisA ...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28176406/imaging-diagnosis-computed-tomographic-angiography-characteristics-of-multiple-vascular-anomalies-in-a-senior-dog-with-late-onset-regurgitation
#9
Hakyoung Yoon, Jaehwan Kim, Gi Bum Kwon, Jin Hyuk Lim, Kidong Eom
A 10-year-old dog weighing 3.4 kg presented with intermittent regurgitation. Esophagography revealed that the thoracic esophagus was compressed dorsally at the region of the fourth intercostal space and segmentally dilated from the second to third intercostal region. Three-dimensional computed tomographic (CT) angiography confirmed a suspected vascular ring anomaly and also revealed multiple other vascular anomalies. These included aberrant right subclavian artery, absence of bilateral external jugular veins, right-gastric caval shunt, and a completely duplicated caudal vena cava...
February 8, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28169924/retrograde-maculopathy-in-patients-with-glaucoma
#10
Jacqueline Brazerol, Milko E Iliev, René Höhn, Stephan Fränkl, Hilary Grabe, Mathias Abegg
PURPOSE: Macular optical coherence tomography (OCT) analysis can be used for quantitative measures of optic nerve atrophy at a location far from the optic nerve head. This recently led to the finding of microcystic macular edema (MME), that is vacuolar inclusions in the macular inner nuclear layer, in some glaucoma patients. The involvement of individual retinal layers is yet unclear in glaucoma. In this study we systematically investigated glaucoma-induced changes in macular layers to evaluate whether glaucoma-associated damage extends beyond the macular ganglion cell layer...
February 6, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28168720/external-morphogenesis-of-the-tardigrade-hypsibius-dujardini-as-revealed-by-scanning-electron-microscopy
#11
Vladimir Gross, Irene Minich, Georg Mayer
Tardigrada, commonly called water bears, is a taxon of microscopic panarthropods with five-segmented bodies and four pairs of walking legs. Although tardigrades have been known to science for several centuries, questions remain regarding many aspects of their biology, such as embryogenesis. Herein, we used scanning electron microscopy to document the external changes that occur during embryonic development in the tardigrade Hypsibius dujardini (Eutardigrada, Parachela, Hypsibiidae). Our results show an accelerated development of external features, with approximately 30 hrs separating the point at which external structures first become recognizable and a fully formed embryo...
February 6, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28168675/vascular-coupling-system-for-end-to-end-anastomosis-an-in-vivo-pilot-case-report
#12
Huizhong Li, Bruce Gale, Jill Shea, Himanshu Sant, Christi M Terry, Jay Agarwal
This paper presents the latest in vivo findings of a novel vascular coupling system. Vascular anastomosis is a common procedure in reconstructive surgeries and traditional hand suturing is very time consuming. The vascular coupling system described herein was designed to be used on arteries for a rapid and error-free anastomosis. The system consists of an engaging ring made from high density polyethylene using computer numerical control machining and a back ring made from polymethylmethacrylate using laser cutting...
February 6, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28165726/synthetic-protein-mimics-for-functional-protein-delivery
#13
Arife Ozgul Tezgel, Paejonette Jacobs, Coralie M Backlund, Janice C Telfer, Gregory N Tew
The use of proteins as biological tools and therapeutic agents is limited due to the fact that proteins do not effectively cross the plasma membrane of cells. Here, we report a novel class of protein transporter molecules based on protein transduction domain mimics (PTDMs) synthesized via ring opening metathesis polymerization (ROMP). The PTDMs reported here were specifically inspired by amphiphilic peptides known to deliver functional proteins into cells via non-covalent interactions between the peptide and cargo...
February 6, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28137288/computer-based-comparison-of-different-methods-for-selecting-mitral-annuloplasty-ring-size
#14
Sameer Al-Maisary, Sandy Engelhardt, Bastian Graser, Ivo Wolf, Matthias Karck, Raffaele De Simone
BACKGROUND: Ring sizing for mitral valve annuloplasty is conventionally done intraoperatively using specific 'sizer' instruments, which are placed onto the valve tissue. This approach is barely reproducible since different sizing strategies have been established among surgeons. The goal of this study is to virtually apply different sizing methods on the basis of pre-repair echocardiography to find out basic differences between sizing strategies. METHODS: In three-dimensional echocardiographs of 43 patients, the mitral annulus and the contour of the anterior mitral leaflet were segmented using MITK Mitralyzer software...
January 30, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28133961/dithieno-fused-polycyclic-aromatic-hydrocarbon-with-a-pyracylene-moiety-strong-antiaromatic-contribution-to-the-electronic-structure
#15
Chaolumen, Michihisa Murata, Atsushi Wakamiya, Yasujiro Murata
A synthetic route to dithieno-fused CP-PAHs with a pyracylene segment is reported. A combination of experimental and theoretical studies revealed a strong contribution of antiaromatic character to the electronic structure of this dithieno-fused CP-PAH. Anisotropy of current-induced density (ACID) calculations indicated a significantly increased paramagnetic ring current on the two pentagonal rings, which is more prominent than that of the dibenzo-fused analogue. Furthermore, enhanced electron affinity and a consequently decreased HOMO-LUMO gap were observed for this dithieno-fused CP-PAH...
January 30, 2017: Organic Letters
https://www.readbyqxmd.com/read/28133888/alterations-of-the-outer-retina-in-non-arteritic-anterior-ischemic-optic-neuropathy-detected-using-spectral-domain-optical-coherence-tomography
#16
Philipp Ackermann, Maike Brachert, Philipp Albrecht, Marius Ringelstein, David Finis, Gerd Geerling, Orhan Aktas, Rainer Guthoff
BACKGROUND: Changes in peripapillary and macular retinal layer thickness in non-arteritic anterior ischemic optic neuropathy (NAION) measured using spectral-domain optical coherence tomography may reflect a characteristic disease pattern. Advanced software enables retinal layer segmentation. In this study, we compared retinal layer thicknesses in acute and chronic NAION. DESIGN: A single-center cross-sectional analysis in a university clinic. PARTICIPANTS: 14 eyes with acute (<7 days) and 13 eyes with chronic NAION and 20 age-matched healthy eyes...
January 30, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28133232/-a-case-of-metachronous-liver-metastases-of-gall-bladder-cancer-successfully-treated-by-liver-resection
#17
Kensuke Asai, Masaru Murata, Kazuhiro Saso, Moyuru Yamada, Hirokazu Sawami, Rei Suzuki, Hiroki Fukunaga, Nobuo Tanaka, Masayuki Yamamoto, Masahiro Hiratsuka
A 73-year-old woman was diagnosed with gall bladder cancer by contrast enhanced CT images.The tumor was detected at the fundus of the gall bladder and enhanced heterogeneously.She underwent radical cholecystectomy including Japanese D2 lymph node dissection for gall bladder cancer.After 4 courses of oral S-1(80mg/m2 administered for 4 weeks and then stopped for 2 weeks)as adjuvant chemotherapy, a liver metastasis at segment 5 appeared 11 months postoperatively.It showed a ring enhanced tumor on contrast enhanced CT images...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28131941/rationally-designed-dual-functional-block-copolymers-for-bottlebrush-like-coatings-in-vitro-and-in-vivo-antimicrobial-antibiofilm-and-antifouling-properties
#18
Qiang Gao, Meng Yu, Yajuan Su, Meihua Xie, Xin Zhao, Peng Li, Peter X Ma
: Numerous antimicrobial coatings have been developed for biomedical devices/implants, but few can simultaneously fulfill the requirements for antimicrobial and antifouling ability and biocompatibility. In this study, to develop an antimicrobial and antibiofilm surface coating, diblock amphiphilic molecules with antimicrobial and antifouling segments in a single chain were rationally designed and synthesized. Cationic antimicrobial polypeptides (AMP) were first synthesized by N-carboxyanhydride ring-opening polymerization (NCA-ROP)...
January 25, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28128962/synthesis-of-the-cyclohepta-e-hydrindane-core-of-the-marine-homoverrucosane-diterpenoid-gagunin-e
#19
Andreas Schäfer, Martin Hiersemann
The synthesis of the A-B-cis B-C-trans annulated cyclohepta[e]hydrindane core of gagunin E with a fully elaborated B-C ring segment has been achieved. Using an adaptable A ring building block, the B ring was annulated by (4 + 2)-cycloaddition and the C ring by ring-closing metathesis. The angular methyl groups were attached by electrophilic cyclopropanation-ring opening.
January 27, 2017: Organic Letters
https://www.readbyqxmd.com/read/28123180/magnesium-prevents-phosphate-induced-vascular-calcification-via-trpm7-and-pit-1-in-an-aortic-tissue-culture-model
#20
Tomohiro Sonou, Masaki Ohya, Mitsuru Yashiro, Asuka Masumoto, Yuri Nakashima, Teppei Ito, Toru Mima, Shigeo Negi, Hiromi Kimura-Suda, Takashi Shigematsu
Previous clinical and experimental studies have indicated that magnesium may prevent vascular calcification (VC), but mechanistic characterization has not been reported. This study investigated the influence of increasing magnesium concentrations on VC in a rat aortic tissue culture model. Aortic segments from male Sprague-Dawley rats were incubated in serum-supplemented high-phosphate medium for 10 days. The magnesium concentration in this medium was increased to demonstrate its role in preventing VC, which was assessed by imaging and spectroscopy...
January 26, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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