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https://www.readbyqxmd.com/read/28932339/penetrating-keratoplasty-for-keratoconus-excimer-versus-femtosecond-laser-trephination
#1
Berthold Seitz, Achim Langenbucher, Tobias Hager, Edgar Janunts, Moatasem El-Husseiny, Nora Szentmáry
BACKGROUND: In case of keratoconus, rigid gas-permeable contact lenses as the correction method of first choice allow for a good visual acuity for quite some time. In a severe stage of the disease with major cone-shaped protrusion of the cornea, even specially designed keratoconus contact lenses are no more tolerated. In case of existing contraindications for intrastromal ring segments, corneal transplantation typically has a very good prognosis. METHODS: In case of advanced keratoconus - especially after corneal hydrops due to rupture of Descemet's membrane - penetrating keratoplasty (PKP) still is the surgical method of first choice...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28931724/vps18-recruits-vps41-to-the-human-hops-complex-via-a-ring-ring-interaction
#2
Morag Hunter, Edward J Scourfield, Edward Emmott, Stephen C Graham
Eukaryotic cells use conserved multisubunit membrane tethering complexes, including CORVET and HOPS, to control the fusion of endomembranes. These complexes have been extensively studied in yeast, but to date there have been far fewer studies of metazoan CORVET and HOPS. Both of these complexes comprise six subunits: a common four-subunit core and two unique subunits. Once assembled, these complexes function to recognise specific endosomal membrane markers and facilitate SNARE-mediated membrane fusion. CORVET promotes the homotypic fusion of early endosomes, while HOPS promotes the fusion of lysosomes to late endosomes and autophagosomes...
September 20, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28921522/extraluminal-biodegradable-splint-to-treat-upper-airway-anterior-malacia-a-preclinical-proof-of-principle
#3
François Gorostidi, Cécile Courbon, Marco Burki, Antoine Reinhard, Kishore Sandu
OBJECTIVE: Upper airway malacia highly complicates the treatment of benign laryngotracheal stenosis, and no ideal option is available to date. We here explore the use of extraluminal biodegradable splints in an animal model of long-segment anterior tracheomalacia (TM). We show the efficacy, as well as the tissue tolerance, of a custom-made biodegradable extraluminal device surgically inserted around the trachea. STUDY DESIGN: Preclinical animal study. METHODS: Anterior TM was induced in rabbits through an anterior neck approach by removing eight consecutive anterior tracheal rings without damaging the underlying mucosa...
September 16, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28917396/modified-bean-shaped-ring-segments-for-suture-fixation-of-the-bag-in-the-lens-intraocular-implant
#4
Sorcha Ní Dhubhghaill, Anca Cristina Dogaroiu, Nadia Zakaria, Marie-José Tassignon
We describe a surgical technique for secondary stabilization of a bag-in-the-lens intraocular lens (BIL IOL) using 2 modified bean-shaped ring segments in cases of zonular dehiscence associated with pseudophakodonesis. The first modified bean segment is anchored in the sulcus with a suture to the sclera in the area of maximum zonular dehiscence, and the second segment is implanted in the opposite sulcus area. Both segments are placed in the BIL IOL interhaptic groove. The segments stabilize and center the BIL IOL by creating an artificial zonule that provides the necessary extra support for the IOL...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28917147/combined-in-silico-approaches-for-the-identification-of-novel-inhibitors-of-human-islet-amyloid-polypeptide-hiapp-fibrillation
#5
Palak Patel, Krupali Parmar, Vivek K Vyas, Dhaval Patel, Mili Das
Human islet amyloid polypeptide (hIAPP) is a natively unfolded polypeptide hormone of glucose metabolism, which is co-secreted with insulin by the β-cells of the pancreas. In patients with type 2 diabetes, IAPP forms amyloid fibrils because of diabetes-associated β-cells dysfunction and increasing fibrillation, in turn, lead to failure of secretory function of β-cells. This provides a target for the discovery of small organic molecules against protein aggregation diseases. However, the binding mechanism of these molecules with monomers, oligomers and fibrils to inhibit fibrillation is still an open question...
September 6, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28915252/expression-and-regulation-of-the-neutral-amino-acid-transporter-b0at1-in-rat-small-intestine
#6
Julia Jando, Simone M R Camargo, Brigitte Herzog, François Verrey
Absorption of neutral amino acids across the luminal membrane of intestinal enterocytes is mediated by the broad neutral amino acid transporter B0AT1 (SLC6A19). Its intestinal expression depends on co-expression of the membrane-anchored peptidase angiotensin converting enzyme 2 (ACE2) and is additionally enhanced by aminopeptidase N (CD13). We investigated in this study the expression of B0AT1 and its auxiliary peptidases as well as its transport function along the rat small intestine. Additionally, we tested its possible short- and long-term regulation by dietary proteins and amino acids...
2017: PloS One
https://www.readbyqxmd.com/read/28913508/confocal-biomicroscopic-changes-of-the-corneal-layers-following-femtosecond-laser-assisted-myoring-implantation-in-keratoconus
#7
Heidar Siatiri, Mahmoud Jabbarvand, Mehrdad Mohammadpour, Amirhossein Mollazadeh, Nasim Siatiri, Arash Mirmohammadsadeghi
PURPOSE: To evaluate the effect of the femtosecond laser-assisted MyoRing implantation on the confocal biomicroscopic findings in different corneal layers of the patients with keratoconus. METHODS: Twelve eyes of 12 patients with mild to moderate keratoconus (keratometry between 48 and 52 diopters) and intolerance to hard contact lens entered the study. All the included patients underwent femtosecond laser-assisted MyoRing (Dioptex GmBH, Linz, Austria) implantation...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28900120/recurrent-network-dynamics-reconciles-visual-motion-segmentation-and-integration
#8
N V Kartheek Medathati, James Rankin, Andrew I Meso, Pierre Kornprobst, Guillaume S Masson
In sensory systems, a range of computational rules are presumed to be implemented by neuronal subpopulations with different tuning functions. For instance, in primate cortical area MT, different classes of direction-selective cells have been identified and related either to motion integration, segmentation or transparency. Still, how such different tuning properties are constructed is unclear. The dominant theoretical viewpoint based on a linear-nonlinear feed-forward cascade does not account for their complex temporal dynamics and their versatility when facing different input statistics...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899499/mechanisms-underlying-antiatherosclerotic-properties-of-an-enriched-fraction-obtained-from-ilex-paraguariensis-a-st-hil
#9
Patrícia Gonçalves Santiago, Francielly Mourão Gasparotto, Karimi Sater Gebara, Flavia Barbieri Bacha, Francislaine Aparecida Dos Reis Lívero, Maria Angélica Strapazon, Euclides Lara Cardozo Junior, Cândida Aparecida Leite Kassuya, Lauro Mera de Souza, Arquimedes Gasparotto Junior
BACKGROUND: Ilex paraguariensis A. St. Hil. var. paraguariensis (Aquifoliaceae) popularly known as 'mate' is an important species native to South America. Despite numerous studies showing significant antioxidant and lipid lowering properties, the antiatherosclerotic mechanisms of this species remain unknown. PURPOSE: To evaluate the possible antiatherosclerotic effects of a butanolic fraction (n-BFIP) obtained from I. paraguariensis and to investigate the molecular mechanisms involved in this activity...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28894642/contrast-based-circular-approximation-for-accurate-and-robust-optic-disc-segmentation-in-retinal-images
#10
Jose Sigut, Omar Nunez, Francisco Fumero, Marta Gonzalez, Rafael Arnay
A new method for automatic optic disc localization and segmentation is presented. The localization procedure combines vascular and brightness information to provide the best estimate of the optic disc center which is the starting point for the segmentation algorithm. A detection rate of 99.58% and 100% was achieved for the Messidor and ONHSD databases, respectively. A simple circular approximation to the optic disc boundary is proposed based on the maximum average contrast between the inner and outer ring of a circle centered on the estimated location...
2017: PeerJ
https://www.readbyqxmd.com/read/28890683/rapid-processing-of-a-global-feature-in-the-on-visual-pathways-of-behaving-monkeys
#11
Jun Huang, Yan Yang, Ke Zhou, Xudong Zhao, Quan Zhou, Hong Zhu, Yingshan Yang, Chunming Zhang, Yifeng Zhou, Wu Zhou
Visual objects are recognized by their features. Whereas, some features are based on simple components (i.e., local features, such as orientation of line segments), some features are based on the whole object (i.e., global features, such as an object having a hole in it). Over the past five decades, behavioral, physiological, anatomical, and computational studies have established a general model of vision, which starts from extracting local features in the lower visual pathways followed by a feature integration process that extracts global features in the higher visual pathways...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28889364/open-complete-anterior-dislocation-of-the-sacro-iliac-joint-in-a-4-year-old-boy-a-case-report-of-a-rare-injury-with-5-year-follow-up
#12
Walid A Elnahal, Mahmoud Fahmy, Mehool Acharya
Pelvic fractures are uncommon in children and account for between 0.3 and 7.5% of all pediatric injuries. Open pelvic fractures only account for up to 12.9% of all pediatric pelvic fractures. An unusual case of open complete anterior sacro-iliac joint dislocation in a 4-year-old boy is presented with a long-term follow-up. The multidisciplinary approach is reported with review of the current literature. A 4-year-old male presented to our institution in January 2012 after having been run over by a tractor. He presented with gross hemodynamical instability, MISS of 25, and an unstable lateral compression type III pelvic fracture with complete anterior dislocation of the left hemipelvis and a groin wound extending into the left thigh...
September 9, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/28888389/scheuermann-s-disease-in-a-juvenile-male-from-the-late-roman-necropolis-of-torrenueva-3rd-4th-century-ce-granada-spain
#13
Joan Viciano, Sandra López-Lázaro, Ángela Pérez-Fernández, Anabel Amores-Ampuero, Ruggero D'Anastasio, José Miguel Jiménez-Triguero
This study details a severe case of Scheuermann's disease (SD) in a well-preserved skeleton of a juvenile male (designated TOR302), dated to 3rd-4th century CE, from the late Roman necropolis of Torrenueva (Granada, Spain). Individual TOR302 shows an evident kyphotic curve in the thoraco-lumbar spine, which is characterised by: (i) vertebral bodies of thoracic vertebra T2, thoracic segment T4-T9, and thoraco-lumbar segment T12-L2 wedged at >5°; (ii) slight anterior extensions of the epiphyseal ring; (iii) Schmorl's nodes on the superior and/or inferior plates; and (iv) a Cobb angle of 75°, derived from thoracic segments T4-T9...
September 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/28880336/toric-icl-implantation-after-sequential-intracorneal-ring-segments-implantation-and-corneal-cross-linking-in-keratoconus-2-year-follow-up
#14
Youssef Abdelmassih, Sylvain El-Khoury, Elias Chelala, Elise Slim, Carole G Cherfan, Elias Jarade
PURPOSE: To evaluate 6-month and 2-year safety and clinical outcomes of Visian toric Implantable Collamer Lens (toric ICL) (STAAR Surgical, Monrovia, CA) implantation for the treatment of residual refractive errors after sequential intracorneal ring segments (ICRS) insertion and cross-linking (CXL) in keratoconus. METHODS: This consecutive case series included the results of a three-step ICRS-CXL-toric ICL procedure in 16 eyes of 13 patients with moderate to severe keratoconus (stages II and III of Amsler-Krumeich classification)...
September 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28878611/low-level-chromosomal-mosaicism-in-neurodevelopmental-disorders
#15
Beatrice Oneda, Reza Asadollahi, Silvia Azzarello-Burri, Dunja Niedrist, Rosa Baldinger, Rahim Masood, Albert Schinzel, Bea Latal, Oskar G Jenni, Anita Rauch
Chromosomal mosaicism, which represents a diagnostic challenge for detection and interpretation, has been described in several genetic conditions. It can contribute to a large phenotypic variation in diseases. At analysis of a well-characterized cohort of 714 patients with neurodevelopmental disorders (NDDs) of unknown etiology using a high-resolution chromosomal microarray platform, we found 2 cases (0.28%) of low-level mosaicism and defined a previously detected extra chromosome in a third patient. Two of the cases were mosaics for segmental imbalances (a partial trisomy 3q26...
August 2017: Molecular Syndromology
https://www.readbyqxmd.com/read/28869225/resection-and-anastomosis-for-benign-tracheal-stenosis-single-institution-experience-of-18-cases
#16
Arvind Kumar, Belal Bin Asaf, Harsh Vardhan Puri, Amr Abdellateef
INTRODUCTION: Tracheal stenosis is a complex condition caused by altered inflammatory response to injury and subsequent excessive circumferential scar formation. Surgical resection, wherever possible, offers the best long-term results. Nonsurgical methods provide immediate relief to all can be curative in few but mostly serve as an excellent bridge to surgery in majority. The purpose of this study is to retrospectively evaluate the outcome following surgery for benign tracheal stenosis at our center...
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28867580/ethanol-potentiates-heat-response-in-the-carotid-artery-via-trpv1
#17
Seham Mustafa, Hishaam N Ismael
AIM: Ethanol is one of the most widely used recreational drugs in the world. At high concentrations, it can induce carotid artery vasoconstriction. Hyperthermia potentiates its effects resulting in carotid artery vasoconstriction at any concentration. The aim of this study is to investigate the interaction between ethanol and heating and to understand the underlying mechanisms leading to their synergistic effect. MATERIALS AND METHODS: Isometric tension of rabbit carotid artery ring segments suspended in organ baths filled with Krebs solution was recorded...
August 31, 2017: Life Sciences
https://www.readbyqxmd.com/read/28867263/effects-of-hyperthyroidism-on-coronary-artery-disease-a%C3%A2-computed-tomography-angiography-study
#18
Christoph Beyer, Fabian Plank, Guy Friedrich, Matthias Wildauer, Gudrun Feuchtner
BACKGROUND: Changes in thyroid hormone concentration can negatively affect the cardiovascular system. Subclinical hyperthyroidism has been linked to an increase of cardiovascular heart disease, however, clinical effects and significance are still uncertain. Therefore, we analyzed coronary computed tomography angiographies of patients with overt and subclinical hyperthyroidism for quantitative parameters and plaque morphology. METHODS: Seven hundred forty-four (47...
July 17, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28865166/asymmetries-in-leaf-branch-are-associated-with-differential-speeds-along-growth-axes-a-theoretical-prediction
#19
Akiko Nakamasu, Nobuhiko J Suematsu, Seisuke Kimura
Morphogenesis, when accompanied by continuous growth, requires stable positional information to create a balanced shape in an organism. Evenly spaced branches are examples of such morphogenesis. Previously, we created a model that showed when a one-dimensional ring (a boundary of a two-dimensional field) was periodically deformed based on a stable, doubled iterative pattern during expansion; a nested, regularly spaced, symmetrically branched structure was generated. The characteristic divaricating pattern is common in the leaves of many plant species; however, the divarication symmetry was often broken...
September 2, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28858044/tonometry-after-intrastromal-corneal-ring-segments-for-keratoconus
#20
Paula Arribas-Pardo, Carmen Mendez-Hernandez, Ricardo Cuiña-Sardiña, José Manuel Benitez-Del-Castillo, Julian Garcia-Feijoo
SIGNIFICANCE: Reliable intraocular pressure (IOP) measurement after intrastromal corneal ring segments (ICRS) implantation is a challenge because of altered corneal morphology. In this study, IOP is measured with four tonometers, compared with Goldmann applanation tonometry (GAT) values and the influence of corneal parameters is established. PURPOSE: This study compares IOP measurements made using different tonometers in patients implanted with ICRS and assesses the effects of central corneal thickness (CCT), corneal curvature, and corneal astigmatism on the IOP measurements obtained...
August 25, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
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