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ring segment

Lucio Urbani, Riccardo Balestri, Francesco Sidoti, Juri Riccardo Bernardini, Francesco Arces, Gabriella Licitra, Chiara Leoni, Francesco Forfori, Piero Colombatto, Piero Boraschi, Maura Castagna, Piero Buccianti
BACKGROUND: Parenchyma-sparing liver surgery allows resecting hepatic veins (HV) at the hepatocaval confluence with minor (<3 adjacent segments) liver resections. PTFE graft can be used as a bridge to communicating-veins maturation to ensure the correct outflow of the spared liver. We present a video of an intrahepatic cholangiocarcinoma (IC) involving the three HV at the hepatocaval confluence treated with this approach. METHODS: In a 50-year old obese (BMI 44...
October 11, 2016: Annals of Surgical Oncology
Zuzana Benková, Pavol Námer, Peter Cifra
The combined effects of the channel asymmetry and the closed chain topology on the chain extension, structure factor, and the orientation correlations were studied using coarse-grained molecular dynamics simulations for moderate chain lengths. These effects are related to applications in linearization experiments with a DNA molecule in nanofluidic devices. According to the aspect ratio, the channels are classified as a stripe or slabs. The chain segments do not have any freedom to move in the direction of the narrowest stripe size, being approximately the same size as the segment size...
October 12, 2016: Soft Matter
Saud M Alfayez, Khalid Allimmia, Ahmad Alshammri, Firas Serro, Rakan Almogbel, Abdullah Bin Dous, Raed Almannie, Jesús Palencia
INTRODUCTION: Urological injuries in pelvic fractures are noticed in 6-15% of the cases. The bladder, due to its anatomical position, is prone to rupture in pelvic fractures. The majority of urinary bladder injuries are either extraperitoneal or intraperitoneal. Nonetheless, both types can occur simultaneously in 6% of the cases. PRESENTATION OF THE CASE: A 45-year-old male was brought to our emergency department after being struck by an automobile. In the absence of signs of urethral injury, a Foley's catheter was inserted revealing gross hematuria...
October 3, 2016: International Journal of Surgery Case Reports
Sen Li, Sai-Jie Zuo, Lei Cao, Dong-Zheng Liu, San-Qi Zhang, Yong-Xiao Cao
A novel 3-benzylquinazolin-4(3H)-one derivative Z32, namely 6,7-dimethoxy-3-(3-chloro-4-(4-fluorobenzyloxy)benzyl)quinazolin-4(3H)-one was synthesized. The vasorelaxant and antihypertensive effects of Z32 and its underlying mechanisms were investigated. The following methods were used. The isometric tension of artery ring segments was recorded using an in vitro myography system. Changes in the calcium influx in mesenteric arteries were surveyed using a real-time confocal microscopy. The arterial pressure of spontaneously hypertensive rats was measured in vivo using a non-invasive tail cuff blood pressure system...
October 5, 2016: European Journal of Pharmacology
George Zardalidis, Julian Mars, Jürgen Allgaier, Markus Mezger, Dieter Richter, George Floudas
The absence of entanglements, the more compact structure and the faster diffusion in melts of cyclic poly(ethylene oxide) (PEO) chains have consequences on their crystallization behavior at the lamellar and spherulitic length scales. Rings with molecular weight below the entanglement molecular weight (M < Me), attain the equilibrium configuration composed from twice-folded chains with a lamellar periodicity that is half of the corresponding linear chains. Rings with M > Me undergo distinct step-like conformational changes to a crystalline lamellar with the equilibrium configuration...
October 4, 2016: Soft Matter
Nicolás Otero, Khaled E El-Kelany, Claude Pouchan, Michel Rérat, Panaghiotis Karamanis
Within an attempt to unravel the conundrum of irregular bandgap variations in hybrids of white-graphene (hBN) and graphene (G) observed in both experiment and theory, strong proofs about the decisive role of aromaticity in their electronic properties are brought to light. Sound numerical experiments conducted on zero-, one- and two-dimensional hBNG hybrids demonstrate that upon structural and/or electronic perturbation caused by foreign doping agents, the uniformity in local cyclic electron delocalization of ideal graphene restructures locally creating carbon hexagons of contrasting cyclic electron delocalization (c...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
David Albrecht, Christian M Winterflood, Mohsen Sadeghi, Thomas Tschager, Frank Noé, Helge Ewers
The axon initial segment (AIS) is enriched in specific adaptor, cytoskeletal, and transmembrane molecules. During AIS establishment, a membrane diffusion barrier is formed between the axonal and somatodendritic domains. Recently, an axonal periodic pattern of actin, spectrin, and ankyrin forming 190-nm-spaced, ring-like structures has been discovered. However, whether this structure is related to the diffusion barrier function is unclear. Here, we performed single-particle tracking time-course experiments on hippocampal neurons during AIS development...
October 10, 2016: Journal of Cell Biology
Yu-Mei Huang, Matthew N Rasband
What prevents the movement of membrane molecules between axonal and somatodendritic domains is unclear. In this issue, Albrecht et. al. (2016. J. Cell Biol. demonstrate via high-speed single-particle tracking and superresolution microscopy that lipid-anchored molecules in the axon initial segment are confined to membrane domains separated by periodically spaced actin rings.
October 10, 2016: Journal of Cell Biology
Igor N Berezovsky, Enrico Guarnera, Zejun Zheng
Study of the hierarchy of domain structure with alternative sets of domains and analysis of discontinuous domains, consisting of remote segments of the polypeptide chain, raised a question about the minimal structural unit of the protein domain. The hypothesis on the decisive role of the polypeptide backbone in determining the elementary units of globular proteins have led to the discovery of closed loops. It is reviewed here how closed loops form the loop-n-lock structure of proteins, providing the foundation for stability and designability of protein folds/domain and underlying their co-translational folding...
September 30, 2016: Progress in Biophysics and Molecular Biology
Nader S Alkenani, Mariam A Alosfoor, Abdulaziz K Al-Araifi, Hala A Alnuaim
INTRODUCTION: This is a case report of extreme lengthening of the tibia of about 14.5cm using bone transport technique following road traffic accident trauma to the lower limbs. The management of the subsequent massive skeletal defects was challenging to orthopedic surgeons. Based on reported cases, the highest tibial lengthening was 22cm using bifocal transport, while the highest unifocal tibial lengthening reached 14.5cm. CASE PRESENTATION: A 20-year-old male driver was brought to the emergency department after a road traffic accident...
September 3, 2016: International Journal of Surgery Case Reports
Daming Sun, Jingbo Zhao, Donghua Liao, Pengmin Chen, Hans Gregersen
A number of factors influence gastrointestinal tissue structure and mechanical properties such as the physical environment and diseases like partial obstruction. Hence multi-axial biomechanical properties are important for understanding the pathophysiology of the obstructed intestine. The aim was to estimate the multi-axial biomechanical properties, in particular with focus on the shear modulus. Partial obstruction of mid-jejunum was created surgically by placement of a polyethylene ring for two weeks in seven male rats...
September 29, 2016: Annals of Biomedical Engineering
Chih-Kuang Chen, Wei-Jen Lin, Yu Hsia, Leu-Wei Lo
Well-defined poly(ethylene glycol)-b-allyl functional polylactide-b-polylactides (PEG-APLA-PLAs) are synthesized through sequential ring-opening polymerization. PEG-APLA-PLAs that have amphiphilic properties and reactive allyl side chains on their intermediate blocks are successfully transferred to core-shell interface cross-linked micelles (ICMs) by micellization and UV-initiated irradiation. ICMs have demonstrated enhanced colloidal stability in physiological-mimicking media. Hydrophobic molecules such as Nile Red or doxorubicin (Dox) are readily loaded into ICMs; the resulting drug-ICM formulations possess slow and sustained drug release profiles under physiological-mimicking conditions...
September 28, 2016: Macromolecular Bioscience
Leonardo Torquetti, Carlos Arce, Jesús Merayo-Lloves, Guilherme Ferrara, Paulo Ferrara, Brenno Signorelli, Armando Signorelli
AIM: To evaluate corneal parameters measured with a dual Scheimpflug analyzer in keratoconus patients implanted with intrastromal corneal ring segments (ICRS). METHODS: Fifty eyes of 40 keratoconus patients had Ferrara ICRS implantation from November 2010 to April 2014. Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), refraction, keratometry, asphericity, elevation, pachymetry, root mean square (RMS), spherical aberration and coma were studied...
2016: International Journal of Ophthalmology
Luke F Gamon, Uta Wille
Air pollution is responsible for the premature death of about 7 million people every year. Ozone (O3) and nitrogen dioxide (NO2(•)) are the key gaseous pollutants in the troposphere, which predominantly result from combustion processes. Their inhalation leads to reactions with constituents in the airway surface fluids (ASF) of the respiratory tract and/or lungs. ASF contain small molecular-weight antioxidants, which protect the underlying epithelial cells against oxidative damage. When this defense system is overwhelmed, proteins and lipids present on cell surfaces or within the ASF become vulnerable to attack...
October 18, 2016: Accounts of Chemical Research
Vladimir Baytshtok, Xue Fei, Robert A Grant, Tania A Baker, Robert T Sauer
The I domain of HslU sits above the AAA+ ring and forms a funnel-like entry to the axial pore, where protein substrates are engaged, unfolded, and translocated into HslV for degradation. The L199Q I-domain substitution, which was originally reported as a loss-of-function mutation, resides in a segment that appears to adopt multiple conformations as electron density is not observed in HslU and HslUV crystal structures. The L199Q sequence change does not alter the structure of the AAA+ ring or its interactions with HslV but increases I-domain susceptibility to limited endoproteolysis...
October 4, 2016: Structure
Carmen Mendez-Hernandez, Paula Arribas-Pardo, Ricardo Cuiña-Sardiña, Cristina Fernandez-Perez, Rosalia Mendez-Fernandez, Federico Saenz-Frances, Jose M Benitez-Del-Castillo, Julian Garcia-Feijoo
PURPOSE: To compare intraocular pressure (IOP) measurements made using 5 tonometers in keratoconic eyes with and without intrastromal corneal ring segments. METHODS AND PATIENTS: This was an observational case series study. A total of 147 eyes of 147 patients with keratoconus, 74 of which had undergone corneal ring segment placement, were prospectively evaluated. IOP was measured using the tonometers Tonopen XL, Pascal dynamic contour tonometer, iCare Pro, ocular response analyzer (ORA), and Goldmann applanation (GAT) in random order...
September 21, 2016: Journal of Glaucoma
Xia Che, Xin Wang, Junyan Zhang, Chengfeng Peng, Yilan Zhen, Xu Shao, Gongliang Zhang, Liuyi Dong
PURPOSE: The aim of this study was to explore the cardioprotective effect of vitexin on chronic myocardial ischemia/reperfusion injury in rats and potential mechanisms. METHODS: A chronic myocardial ischemia/reperfusion injury model was established by ligating left anterior descending coronary for 60 minutes, and followed by reperfusion for 14 days. After 2 weeks ischemia/reperfusion, cardiac function was measured to assess myocardial injury. The level of ST segment was recorded in different periods by electrocardiograph...
2016: American Journal of Translational Research
Jacob B Gross, Garvin H Davis, Nicholas P Bell, Robert M Feldman, Lauren S Blieden
PURPOSE: To describe a new surgical technique to effectively close large (>180 degrees) cyclodialysis clefts. METHODS: Our method involves the use of procedures commonly associated with repair of retinal detachment and complex cataract extraction: phacoemulsification with placement of a capsular tension ring followed by pars plana vitrectomy and gas tamponade with light cryotherapy. We also used anterior segment optical coherence tomography (OCT) as a noninvasive mechanism to determine the extent of the clefts and compared those results with ultrasound biomicroscopy (UBM) and gonioscopy...
September 13, 2016: European Journal of Ophthalmology
Byron L Lam, Samuel P Burke, Mindy X Wang, Gloria A Nadayil, Potyra R Rosa, Giovanni Gregori, William J Feuer, Sophia Cuprill-Nilson, Ruth Vandenbroucke, Xiaojun Zhang, John Guy
BACKGROUND AND OBJECTIVE: To determine macular retinal sublayer thickness changes in G11778A Leber hereditary optic neuropathy (LHON). PATIENTS AND METHODS: The authors performed a cross-sectional study by segmenting spectral-domain Cirrus OCT (Carl Zeiss Meditec, Dublin, CA) 512 × 128 macular cube scans from a prospective, observational study of G11778A LHON. The thickness of the retinal sublayers of LHON affected subjects and asymptomatic carriers were compared to those of a normal group...
September 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Diana Vicente, Blanca Hernández, Vanessa Segura, Desirée Pascual, Giacomo Fornaciari, Fermí Monto, Vicente Mirabet, M Carmen Montesinos, Pilar DʼOcon
The sprouting of new vessels is greatly influenced by the procedure chosen. We sought to optimize the experimental conditions of the angiogenic growth of fresh and cryopreserved vessels cultured in Matrigel with the aim to use this system to analyze the pharmacological modulation of the process. Segments of second-order branches of rat mesenteric resistance arteries, thoracic aorta of rat or mouse, and cryopreserved rat aorta and human femoral arteries were cultured in Matrigel for 7-21 days in different mediums, as well as in the absence of endothelial or adventitia layer...
September 2016: Journal of Cardiovascular Pharmacology
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