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https://www.readbyqxmd.com/read/29775791/an-imaging-biomarker-for-assessing-hepatic-function-in-patients-with-primary-sclerosing-cholangitis
#1
Jennifer Schulze, Henrike Lenzen, Jan B Hinrichs, Burckhardt Ringe, Michael P Manns, Frank Wacker, Kristina I Ringe
BACKGROUND & AIMS: We aimed to evaluate the potential of hepatobiliary phase magnetic resonance imaging (MRI) as parameter for assessment of hepatocellular function in patients with primary sclerosing cholangitis (PSC). METHODS: We collected data from 111 patients (83 male, 28 female; median, 44 years old), from March 2012 through March 2016, with a confirmed diagnosis of PSC who underwent MRI evaluation before and after injection (hepatobiliary phase) of a hepatocyte-specific contrast agent (gadoxetate disodium)...
May 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29774226/metastatic-gastric-signet-ring-cell-carcinoma-mimicking-crohn-s-disease
#2
Michael W Winter, Amr Dokmak, Zachary Marnoy, Shweta Sinagare, Alexander N Levy
Signet-ring cell carcinoma (SRCC) is an adenocarcinoma characterized by mucin-producing cells and most commonly arises in the stomach. Colonic SRCC can share features of colitis, including long segments of concentric bowel wall thickening and ulcerated mucosa with regions of sparing. We describe a rare case of metastatic gastric SRCC mimicking Crohn's disease. Our patient underwent 2 colonoscopies, and biopsies revealed chronic active inflammation with no evidence of malignancy. The diagnosis of SRCC was only made after colectomy was performed for recurrent bowel obstruction...
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29765745/crystal-structure-of-2-oxopyrrolidin-3-yl-4-2-phenyl-diazen-1-yl-benzoate
#3
Igor Elkin, Thierry Maris, Alexandre Melkoumov, Patrice Hildgen, Xavier Banquy, Grégoire Leclair, Christopher Barrett
In the title compound, C17 H15 N3 O3 , the plane of the pyrrolidone ring is inclined at an angle of 59.791 (2)° to that of the azo-benzene segment, which adopts a configuration close to planar. In the crystal, mol-ecules are oriented pairwise by (2-oxopyrrolidin-3-yl)-oxy moieties at an angle of 76.257 (3)°, linked by hydrogen bonds and π-stacking inter-actions, forming zigzag supra-molecular chains parallel to [010] further linked via additional C-H⋯π inter-actions.
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29762781/the-tubr-centromere-complex-adopts-a-double-ring-segrosome-structure-in-type-iii-partition-systems
#4
Bárbara Martín-García, Alejandro Martín-González, Carolina Carrasco, Ana M Hernández-Arriaga, Rubén Ruíz-Quero, Ramón Díaz-Orejas, Clara Aicart-Ramos, Fernando Moreno-Herrero, María A Oliva
In prokaryotes, the centromere is a specialized segment of DNA that promotes the assembly of the segrosome upon binding of the Centromere Binding Protein (CBP). The segrosome structure exposes a specific surface for the interaction of the CBP with the motor protein that mediates DNA movement during cell division. Additionally, the CBP usually controls the transcriptional regulation of the segregation system as a cell cycle checkpoint. Correct segrosome functioning is therefore indispensable for accurate DNA segregation...
May 14, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29758267/the-functional-architecture-of-axonal-actin
#5
REVIEW
Marie-Jeanne Papandréou, Christophe Leterrier
The cytoskeleton builds and supports the complex architecture of neurons. It orchestrates the specification, growth, and compartmentation of the axon: axon initial segment, axonal shaft, presynapses. The cytoskeleton must then maintain this intricate architecture for the whole life of its host, but also drive its adaptation to new network demands and changing physiological conditions. Microtubules are readily visible inside axon shafts by electron microscopy, whereas axonal actin study has long been focused on dynamic structures of the axon such as growth cones...
May 11, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29755840/treatment-of-mallet-finger-deformity-with-a-modified-palmaris-longus-tendon-graft-through-a-bone-tunnel
#6
Zengbing Liu, Kai Ma, Dong Huang
OBJECTIVE: To investigate the clinical effect of treating mallet finger deformity using a modified palmaris longus tendon graft through a bone tunnel. METHODS: Altogether, 21 patients with mallet finger deformity (16 men, 5 women; average age 31 years, range 19-47 years) were treated with a modified palmaris longus tendon graft through a bone tunnel during 18 months (2014-2016). Four index fingers, seven middle fingers, eight ring fingers, and two little fingers were treated for four cutting injuries, eleven finger sprains, four crush injuries, and two twist injuries (7 open and 14 closed injuries)...
2018: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/29752586/comparison-of-tracheal-reconstruction-with-allograft-fresh-xenograft-and-artificial-trachea-scaffold-in-a-rabbit-model
#7
Jae Yeon Lee, Jeong Hun Park, Dong-Woo Cho
This study evaluated the possibility of tracheal reconstruction with allograft, pig-to-rabbit fresh xenograft or use of a tissue-engineered trachea, and compared acute rejection of three different transplanted tracheal segments in rabbits. Eighteen healthy New Zealand White rabbits weighing 2.5-3.1 kg were transplanted with three different types of trachea substitutes. Two rabbits and two alpha 1, 3-galactosyltransferase gene-knockout pigs weighing 5 kg were used as donors. The rabbits were divided into three groups: an allograft control group consisting of rabbit-to-rabbit allotransplantation animals (n = 6), a fresh xenograft group consisting of pig-to-rabbit xenotransplantation animals (n = 6), and an artificial trachea scaffold group (n = 6)...
May 12, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29752535/tissue-accumulation-patterns-and-concentrations-of-potassium-phosphorus-and-carboxyfluorescein-translocated-from-pine-seed-to-the-root
#8
Thomas C Pesacreta, Karl H Hasenstein
Potassium (K), phosphorous (P), and carboxyfluorescein (CF) accumulate in functionally distinct tissues within the pine seedling root cortex. Seedlings of Pinus pinea translocate exogenous CF and endogenous K and P from the female gametophyte/cotyledons to the growing radicle. Following unloading in the root tip, these materials accumulate in characteristic spatial patterns. Transverse sections of root tips show high levels of P in a circular ring of several layers of inner cortical cells. K and CF are minimal in the high P tissue...
May 11, 2018: Planta
https://www.readbyqxmd.com/read/29750930/a-simplified-technique-for-complex-mitral-valve-regurgitation-via-minimally-invasive-approach
#9
Giuseppe Speziale, Marco Moscarelli, Nicola Di Bari, Raffaele Bonifazi, Massimo Salardino, Teresa De Donatis, Giusepe Nasso
BACKGROUND: Complex mitral valve disease can require surgical repair techniques that are challenging in a minimally invasive context and may expose patients to prolonged cardiopulmonary bypass and cross clamp times. Here, we review our simplified stepwise operative approach for the treatment of complex bileaflet mitral disease, on early outcomes and mid-term follow-up. METHODS: One hundred and forty consecutive patients with bileaflet disease underwent video-assisted right minimally invasive mitral valve repair at our surgical center between 2008 and 2016...
May 8, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29750407/mitral-valve-repair-with-adjustable-ring-annuloplasty
#10
Martin Andreas, Thomas Haberl, Werner Paul, Jani Guri, Alfred Kocher, Ouafa Hamza, Bruno Podesser, Guenther Laufer
We demonstrate the technical aspects of a novel adjustable mitral ring. This new ring was implanted in a female landrace pig, for training and educational purposes. It can be adjusted independently in the P1, P2 and P3 segments, if required, to treat  recurrent mitral regurgitation, and this is a key difference to comparable devices. The first-in-man implantation is anticipated in the near future.
February 28, 2018: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://www.readbyqxmd.com/read/29738584/corneal-allogenic-intrastromal-ring-segments-cairs-combined-with-corneal-cross-linking-for-keratoconus
#11
Soosan Jacob, Shaila R Patel, Amar Agarwal, Arvind Ramalingam, A I Saijimol, John Michael Raj
PURPOSE: To describe a new technique for the treatment of keratoconus using corneal allogenic intrastromal ring segments (CAIRS). METHODS: CAIRS trephined from donor cornea using a double-bladed trephine were implanted into mid-depth femtosecond laser-dissected channels in the cornea of patients with keratoconus in the 6.5-mm optic zone, followed by accelerated corneal cross-linking (A-CXL)-either conventional or contact lens-assisted CXL (A-CACXL), depending on minimum corneal thickness...
May 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29736923/reconstruction-of-complex-tissue-defect-of-forearm-with-a-chimeric-flap-composed-of-a-sural-neurocutaneous-flap-and-a-vascularized-fibular-graft-a-case-report
#12
Chunyang Wang, Jia Xu, Gen Wen, Yimin Chai
One-stage reconstruction of composite bone and soft-tissue defects in the forearm remains a tough challenge. Here, we present a case of reconstruction of complex tissue defect at forearm with a chimeric flap consisting of a sural neurocutaneous flap and a fibular graft. A 61-year-old man suffered from a machine crush injury in his left forearm, resulting in a complex tissue defect including extensive dorsomedial soft-tissue, digit extensor muscles of 2-4 fingers, the muscle flexor carpi ulnaris, the ulna bone with 5...
May 7, 2018: Microsurgery
https://www.readbyqxmd.com/read/29732077/macrocyclic-poly-p-phenylenevinylene-s-by-ring-expansion-metathesis-polymerisation-and-their-characterisation-by-single-molecule-spectroscopy
#13
Benjamin John Lidster, Shuzo Hirata, Shoki Matsuda, Takuya Yamamoto, Venukrishnan Komanduri, Dharam Raj Kumar, Yasuyuki Tezuka, Martin Vacha, Michael L Turner
Ring expansion metathesis polymerisation (REMP) has proven to be a viable approach to prepare high purity cyclic polymers. Macrocyclic polymers with a fully conjugated defect free backbone are of particular interest as these polymers have no end groups that can act as charge traps. In this work soluble macrocyclic poly( p -phenylenevinylene)s ( c PPV s) have been prepared directly via the REMP of substituted paracyclophanedienes. Single-molecule spectroscopy of the two topological forms of PPV i.e. , linear ( l PPV ) and cyclic ( c PPV ) revealed that l PPV exists in an extended conformation whereas the c PPV adopts a restricted ring-like conformation...
March 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29728290/posterior-cornea-and-thickness-changes-after-scleral-lens-wear-in-keratoconus-patients
#14
Maria Serramito, Carlos Carpena-Torres, Jesús Carballo, David Piñero, Michael Lipson, Gonzalo Carracedo
PURPOSE: To evaluate the changes in the corneal thickness, anterior chamber depth and posterior corneal curvature and aberrations after scleral lens wear in keratoconus patients with and without intrastromal corneal ring segments (ICRS). METHODS: Twenty-six keratoconus subjects (36.95 ± 8.95 years) were evaluated after 8 h of scleral lens wear. The subjects were divided into two groups: those with ICRS (ICRS group) and without ICRS (KC group). The study variables evaluated before and immediately after scleral lens wear included corneal thickness evaluated in different quadrants, posterior corneal curvature at 2, 4, 6 and 8 mm of corneal diameter, posterior corneal aberrations for 4, 6 and 8 mm of pupil size and anterior chamber depth...
May 1, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29725515/a-limb-threatening-long-arterial-dissection-caused-by-humerus-neck-fracture-a-case-report
#15
R Kurnaz, M Ikizler, M Ozbayburtlu, T Gunes
Proximal humerus fracture is a common arm trauma and rarely occurs with vascular injury which however is a serious complication. In this case report, we present a long segment dissection of the axillary and brachial arteries as a rare complication due to fragmented proximal humerus fracture and shoulder dislocation. An 80-year old female patient was seen at the emergency department. Radiograph examination has revealed a fragmented proximal humerus fracture besides dislocation of the head of humerus towards the axillary area...
March 2018: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29715767/ultrafast-pm-fiber-ring-laser-mode-locked-by-nonlinear-polarization-evolution-with-short-npe-section-segments
#16
Wenchao Zhang, Yang Liu, Chao Wang, Zhiwei Zhu, Daping Luo, Chenlin Gu, Wenxue Li
We demonstrate a nonlinear polarization evolution (NPE) mode-locked polarization maintaining (PM) Yb-doped fiber laser with short NPE section segments by setting proper splicing angle. With a theoretical analysis, we propose that an appropriate deviation splicing angle exists to maximize the adjustable range of transmission modulation. The simulation results are highly consistent with theoretical conclusions. Experimentally, using the optimal splicing angle predicted by the theoretical calculation, we have achieved an environmentally stable mode-locking fiber laser at 111-MHz repetition rate with corresponding pulse energy of 0...
April 2, 2018: Optics Express
https://www.readbyqxmd.com/read/29703635/differences-in-the-association-of-total-versus-local-coronary-artery-calcium-with-acute-coronary-syndrome-and-culprit-lesions-in-patients-with-acute-chest-pain-the-coronary-calcium-paradox
#17
Stefan B Puchner, Thomas Mayrhofer, Jakob Park, Michael T Lu, Ting Liu, Pal Maurovich-Horvat, Khristine Ghemigian, Daniel O Bittner, Jerome L Fleg, James E Udelson, Quynh A Truong, Udo Hoffmann, Maros Ferencik
BACKGROUND AND AIMS: Total coronary artery calcium (CAC) burden is associated with an increased cardiovascular risk, while local CAC may represent stable plaques. We determined differences in relationship of total CAC with acute coronary syndrome (ACS) and local CAC with culprit lesions in patients with suspected ACS. METHODS: We performed computed tomography (CT) for CAC and CT angiography to assess the presence of significant stenosis and high-risk plaque (positive remodeling, low CT attenuation, napkin-ring sign, spotty calcium) in 37 patients with ACS and 223 controls...
April 17, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29701396/takayasus-s-aortitis-induced-ascending-aorta-dissection
#18
Bruno Fernandes, Joana Saraiva, Lina Carvalho
INTRODUCTION: Takayasu aortitis is a well known yet rare form of large vessel vasculitis. Also known as pulseless disease, occlusive thromboaortopathy, and Martorell syndrome, is a chronic inflammatory aortitis. Vessel inflammation leads to wall thickening, fibrosis, stenosis, and thrombus formation. METHODS: A 64-year-old woman was referred to emergency for lack of pulse in the upper and lower limbs and changes in heart rate. AngioRMN revealed dissection of the ascending aorta while in PET, intense uptake of FDG-F18 involving ascending, crossa, descending thoracic and abdominal segments of the aorta, was evident urgent surgical correction occurred...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29700864/bicuspid-and-tricuspid-aortic-valve-do-not-have-the-same-ascending-aorta-morphology
#19
N d'Ostrevy, H Ngo, B Magnin, K Azarnoush, L Cassagnes, L Camilleri
INTRODUCTION: Bicuspid aortic valves are associated with histopathological abnormalities of the aorta. Their diameters have been measured in several studies, but the literature concerning changes in the overall anatomy of the ascending aorta is limited. We wanted to know whether the anatomy of the valve, bicuspid or tricuspid, is associated with anatomical differences. MATERIALS AND METHODS: We prospectively included patients requiring aortic valve surgery. The protocol included a chest CT scan before the operation to determine the angulations and straight lengths of aortic segments 0 and 1...
April 26, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29677360/distinctive-analysis-of-macular-superficial-capillaries-and-large-vessels-using-optical-coherence-tomographic-angiography-in-healthy-and-diabetic-eyes
#20
Jianqin Lei, Enhui Yi, Yan Suo, Cheng Chen, Xiayu Xu, Wenxiang Ding, Nizar Saleh Abdelfattah, Xiaojuan Fan, Huiqin Lu
Purpose: To quantify and evaluate macular superficial capillaries and large vessels separately using an optical coherence tomographic angiography (OCTA)-based automatic segmentation algorithm. Methods: In this cross-sectional study, all eyes were scanned using an OCTA device with 3 × 3 mm cube centered on the fovea. Retinal large vessels (arterioles/venules) were automatically segmented from superficial vasculature en-face images. All images were normalized, binarized, and skeletonized for quantification...
April 1, 2018: Investigative Ophthalmology & Visual Science
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