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https://www.readbyqxmd.com/read/28732616/stromal-remodeling-and-lenticule-thickness-accuracy-in-small-incision-lenticule-extraction-one-year-results
#1
Nikolaus Luft, Siegfried G Priglinger, Michael H Ring, Wolfgang J Mayer, Anna S Mursch-Edlmayr, Thomas C Kreutzer, Matthias Bolz, Martin Dirisamer
PURPOSE: To prospectively characterize the stromal thickness changes during the first year after myopic small-incision lenticule extraction using spectral-domain optical coherence tomography (SD-OCT). SETTING: Department of Ophthalmology, Kepler University Hospital, Linz, Austria. DESIGN: Prospective case series. METHODS: This study evaluated eyes that had small-incision lenticule extraction to treat myopia or myopic astigmatism...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28732604/artificial-iris-implantation-in-various-iris-defects-and-lens-conditions
#2
Christian Mayer, Tamer Tandogan, Andrea E Hoffmann, Ramin Khoramnia
We describe 6 surgical techniques used to implant a silicone iris prosthesis: sector-shaped iris segments that require suturing, injector-assisted sulcus fixation, injector-assisted capsular bag fixation with an intraocular lens (IOL) and capsular tension ring, folded iris tissue implanted with a forceps and sutured to the sclera with a scleral-fixated IOL, "sandwich" or "backpack" implantation with an IOL, and open-sky implantation with a perforating keratoplasty. The results of the techniques performed in 51 patients are discussed...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28731705/reversible-self-assembly-of-degradable-polymersomes-with-upper-critical-solution-temperature-in-water
#3
Thomas Wolf, Timo Rheinberger, Johanna Simon, Frederik R Wurm
Temperature-induced self-assembly of block copolymers allows the formation of smart nanodimensional structures. Mostly, non-degradable LCST segments are applied to prepare such dynamic aggregates. However, degradable UCST block copolymers that would allow the swelling or disassembly at elevated temperatures with eventual backbone hydrolysis have not been reported to date. We present the first well-defined degradable poly(phosphonate)s with adjustable UCST. The organocatalytic anionic ring-opening copolymerization of 2-alkyl-2-oxo-1,3,2-dioxaphospholanes provided functional polymers with excellent control over molecular weight and copolymer composition...
July 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28724839/effect-of-recurrent-mitral-regurgitation-after-mitral-valve-repair-in-patients-with-degenerative-mitral-regurgitation
#4
Jung-Hwan Kim, Seung Hyun Lee, Hyun-Chel Joo, Young-Nam Youn, Kyung-Jong Yoo, Byung-Chul Chang, Sak Lee
BACKGROUND: This study investigated the consequences of recurrent mitral regurgitation (MR) after mitral valve (MV) repair in patients with degenerative MR and risk factors for recurrence.Methods and Results:From January 1990 to December 2015, 792 patients underwent MV repair due to degenerative MR. Recurrent MR was defined as moderate-to-severe MR on follow-up echocardiography. Mean follow-up duration was 8.71±5.58 years. During the follow-up period, MR recurred in 133 (16.8%) patients, and the MR recurrence-free rate at 20 years was 77...
July 20, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28714285/dynamic-cooperation-of-hydrogen-binding-and-%C3%AF-stacking-in-ssdna-adsorption-on-graphene-oxide
#5
Zhen Xu, Xiaoling Lei, Yusong Tu, Zhi-Jie Tan, Bo Song, Haiping Fang
Functional nanoscale structures consisting of a DNA molecule coupled to graphene or graphene oxide (GO) have great potential for applications in biosensors, biomedicine, nanotechnology, and materials science. Extensive studies using the most sophisticated experimental techniques and theoretical methods have still not clarified the dynamic process of single-stranded DNA (ssDNA) adsorbed on a GO surface. Based on a molecular dynamics simulation, this work shows that an ssDNA segment could be stably adsorbed on a GO surface through hydrogen bonding and a π-π stacking interaction, with preferential binding to an oxidized region rather than to an unoxidized region of the GO surface...
July 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28712961/disruption-in-non-anastomotic-section-of-an-axillofemoral-bypass-a-thorough-critical-review-of-the-literature
#6
REVIEW
S Valverde García, R Peña Cortés, J Torre Eiriz, M B García-Cenador, F S Lozano Sánchez
This work is a thorough non-systematic critical review (PubMed/Medline 1950-september 2016) of "disruption in non-anastomotic section of an axillofemoral bypass". Fourteen cases were selected (including that provided by the authors of this publication) dating from 1963 to 2016 (53 years). This type of disruption is a very unusual complication in axillofemoral bypass. The cases described reveal that this disorder is more frequent in unifemoral bypass (9 cases), in ringed PTFE (10), in blunt trauma (8) and at costal level (12) especially on the left side (8)...
July 13, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28709396/rapid-diversification-of-homothorax-expression-patterns-after-gene-duplication-in-spiders
#7
Natascha Turetzek, Sara Khadjeh, Christoph Schomburg, Nikola-Michael Prpic
BACKGROUND: Gene duplications provide genetic material for the evolution of new morphological and physiological features. One copy can preserve the original gene functions while the second copy may evolve new functions (neofunctionalisation). Gene duplications may thus provide new genes involved in evolutionary novelties. RESULTS: We have studied the duplicated homeobox gene homothorax (hth) in the spider species Parasteatoda tepidariorum and Pholcus phalangioides and have compared these data with previously published data from additional spider species...
July 14, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28706869/posterior-suture-annuloplasty-for-functional-tricuspid-regurgitation
#8
Vakhtang Tchantchaleishvili, Taufiek K Rajab, Lawrence H Cohn
Functional tricuspid regurgitation (TR) is primarily caused by enlargement of the tricuspid annulus due to right ventricular dilation, frequently secondary to left sided valvular disease. Early techniques for the treatment of functional TR were introduced by Jerome Kay in 1965 and Norberto DeVega in 1972. Modified suture annuloplasty is a modification of DeVega's semicircular purse string technique, however, it is based on Kay's principle of obliteration of the posterior segment of the annulus only. While ring annuloplasty is the procedure of choice for severe functional TR, posterior suture annuloplasty is a technically simpler option for patients with moderate functional TR...
May 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28697003/the-respect-rather-than-resect-principle-in-mitral-valve-repair-the-lateral-dislocation-of-the-p2-technique
#9
Marco Zanobini, Gabriella Ricciardi, Francesco Liborio Mammana, Samer Kassem, Paolo Poggio, Alessandro Di Minno, L Cavallotti, Matteo Saccocci
BACKGROUND: Leaflet resection represents the reference standard for surgical treatment of mitral valve (MV) regurgitation. New approaches recently proposed place emphasis on respecting, rather than resecting, the leaflet tissue to avoid the drawbacks of the 'resection' approach. OBJECTIVES: The lateral dislocation of mid portion of mitral posterior leaflet (P2) technique for MV repair is a nonresectional technique in which the prolapsed P2 segment is sutured to normal P1 segment...
July 10, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28683485/-therapeutic-options-in-keratoconus
#10
Frederik Raiskup, Janine Lenk, Robert Herber, Zisis Gatzioufas, Eberhard Spörl
A recent epidemiology study revealed that prevalence of keratoconus was much higher than previously assumed. Therefore, it is no longer deemed an "orphan disease", as it has a relevant socioeconomic impact on the healthcare system. One of the most important risk factors for developing keratoconus is chronic eye rubbing which, apart from other known risk factors such as atopy or Down's syndrome, is the only modifiable factor. Informing the patient and offering behavior modifying therapies seems to be essential...
July 6, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28682307/cryo-em-structure-of-the-protein-conducting-erad-channel-hrd1-in-complex-with-hrd3
#11
Stefan Schoebel, Wei Mi, Alexander Stein, Sergey Ovchinnikov, Ryan Pavlovicz, Frank DiMaio, David Baker, Melissa G Chambers, Huayou Su, Dongsheng Li, Tom A Rapoport, Maofu Liao
Misfolded endoplasmic reticulum (ER) proteins are retro-translocated through the membrane into the cytosol, where they are poly-ubiquitinated, extracted from the ER membrane, and degraded by the proteasome(1-4), a pathway termed ER-associated protein degradation (ERAD). Proteins with misfolded domains in the ER lumen or membrane are discarded through the ERAD-L and -M pathways, respectively. In S. cerevisiae, both pathways require the ubiquitin ligase Hrd1, a multi-spanning membrane protein with a cytosolic RING finger domain(5,6)...
July 6, 2017: Nature
https://www.readbyqxmd.com/read/28681904/bean-shaped-ring-segments-as-a-capsule-enhancement-tool-in-complex-bag-in-the-lens-intraocular-lens-implantation
#12
Ate Altenburg, Sorcha S Ní Dhubhghaill, Marie-José Tassignon
PURPOSE: To describe the outcome of a novel capsular or sulcular device to support the bag-in-the-lens (BIL) implant in cases of capsular or zonular instability. Bean-shaped ring segments or 'beans' (Morcher GmbH, Stuttgart, Germany) are designed to fit the groove of the BIL and may be placed in either the capsule or the ciliary sulcus in cataract cases with loose zonules or unstable capsule. METHODS: This was a retrospective single center observational study of all consecutive cases of bean implantation between May 2011 and April 2015...
July 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28679132/comment-on-advantages-of-anterior-segment-optical-coherence-tomography-evaluation-of-the-kayser-fleischer-ring-in-wilson-disease
#13
Niklas Telinius, Peter Ott, Jesper Hjortdal
No abstract text is available yet for this article.
August 2017: Cornea
https://www.readbyqxmd.com/read/28663088/thermoplastic-polyurethane-based-intravaginal-rings-for-prophylaxis-and-treatment-of-recurrent-bacterial-vaginosis
#14
G Verstraete, L Vandenbussche, S Kasmi, L Nuhn, D Brouckaert, J Van Renterghem, W Grymonpré, V Vanhoorne, T Coenye, B G De Geest, T De Beer, J P Remon, C Vervaet
The aim of the present study was to develop thermoplastic polyurethane (TPU)-based intravaginal rings (IVRs) for prophylaxis and treatment of bacterial vaginosis via hot melt extrusion/injection molding. Therefore, different TPU grades were processed in combination with lactic acid or metronidazole, targeting a sustained lactic acid release over a 28day-period and sustained metronidazole release over 4-7days. Hot melt extrusion of lactic acid/TPU combinations required a lower extrusion temperature due to the plasticizing properties of lactic acid, evidenced by the lower glass transition temperature (Tg) and cross-over point (Ttanδ=1) values...
June 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28658437/indications-and-visual-outcomes-of-intrastromal-corneal-ring-segment-implantation-in-a-large-patient-series
#15
Taíse Tognon, Mauro Campos, João Paulo Wengrzynovski, Kleyton Arlindo Barella, Adriano Pasqualotti, Luiz Antônio de Brito Martins, Adriana Dos Santos Forseto, Luciene Barbosa de Sousa
OBJECTIVES: To describe the indications for and visual outcomes of intrastromal corneal ring segment implantation. METHODS: A large retrospective case-series chart-review study was conducted using Sorocaba Ophthalmological Hospital medical records. This study included 1222 eyes (1196 patients) that were surgically treated between November 2009 and December 2012. The following preoperative data were collected: age, gender, type of medical care and funding source, surgical technique, best-corrected visual acuity, manifest sphere and cylinder refractive error, maximum and minimum central keratometry, and pachymetry measurements of the cornea at the thinnest point and at the ring channel...
June 2017: Clinics
https://www.readbyqxmd.com/read/28632845/iris-malformation-and-anterior-segment-dysgenesis-in-mice-and-humans-with-a-mutation-in-pi-3-kinase
#16
Marie H Solheim, Allen C Clermont, Jonathon N Winnay, Erlend Hallstensen, Anders Molven, Pål R Njølstad, Eyvind Rødahl, C Ronald Kahn
Purpose: To determine the ocular consequences of a dominant-negative mutation in the p85α subunit of phosphatidylinositol 3-kinase (PIK3R1) using a knock-in mouse model of SHORT syndrome, a syndrome associated with short stature, lipodystrophy, diabetes, and Rieger anomaly in humans. Methods: We investigated knock-in mice heterozygous for the SHORT syndrome mutation changing arginine 649 to tryptophan in p85α (PIK3R1) using physical examination, optical coherence tomography (OCT), tonometry, and histopathologic sections from paraffin-embedded eyes, and compared the findings to similar investigations in two human subjects with SHORT syndrome heterozygous for the same mutation...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28623470/reconstruction-of-aaos-type-iii-and-iv-acetabular-defects-with-the-ganz-reinforcement-ring-high-failure-in-pelvic-discontinuity
#17
Cynthia Hourscht, Mohammad K Abdelnasser, Sufian S Ahmad, Lukas Kraler, Marius J Keel, Klaus A Siebenrock, Frank M Klenke
BACKGROUND: Large acetabular defects and pelvic discontinuity represent complex problems in revision total hip arthroplasty. This study aimed to investigate whether reconstruction with the Ganz reinforcement ring would provide durable function in large acetabular defects. PATIENTS AND METHODS: 46 hips (45 patients, 19 male, 26 female, mean age 68 years) with AAOS type III and IV defects undergoing acetabular revision with the Ganz reinforcement ring were evaluated at a mean follow-up of 74 months (24-161 months)...
June 16, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28619543/circumferential-three-dimensional-printed-tracheal-grafts-research-model-feasibility-and-early-results
#18
Faiz Y Bhora, Erik E Lewis, Sadiq S Rehmani, Adil Ayub, Wissam Raad, Adnan M Al-Ayoubi, Robert S Lebovics
BACKGROUND: Methods for tracheal graft research have presented persistent challenges to investigators, and three-dimensional (3D)-printed biosynthetic grafts offer one potential development platform. We aimed to develop an efficient research platform for customizable circumferential 3D-printed tracheal grafts and evaluate feasibility and early structural integrity with a large-animal model. METHODS: Virtual 3D models of porcine subject tracheas were generated using preoperative computed tomography scans...
June 13, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28611586/the-distribution-of-charged-amino-acid-residues-and-the-ca-2-permeability-of-nicotinic-acetylcholine-receptors-a-predictive-model
#19
Sergio Fucile
Nicotinic acetylcholine receptors (nAChRs) are cation-selective ligand-gated ion channels exhibiting variable Ca(2+) permeability depending on their subunit composition. The Ca(2+) permeability is a crucial functional parameter to understand the physiological role of nAChRs, in particular considering their ability to modulate Ca(2+)-dependent processes such as neurotransmitter release. The rings of extracellular and intracellular charged amino acid residues adjacent to the pore-lining TM2 transmembrane segment have been shown to play a key role in the cation selectivity of these receptor channels, but to date a quantitative relationship between these structural determinants and the Ca(2+) permeability of nAChRs is lacking...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28608030/intracorneal-ring-segment-depth-in-keratoconus-patients-a-long-term-follow-up-study
#20
Saied Shahhoseini, Hassan Hashemi, Soheila Asgari
PURPOSE: To compare the actual depth of the tunnel created with femtosecond laser for intracorneal ring segment (ICRS) implantation with the target depth in keratoconus patients. METHODS: In this mix design study, eligible keratoconus patients were identified through chart review. The inclusion criterion was a history of ICRS implantation with femtosecond laser more than 6 months prior to enrollment. Participants underwent anterior segment optical coherence tomography using Spectralis (Heidelberg Engineering GmbH, Heidelberg, Germany) for depth measurement defined as the distance from the anterior corneal surface to anterior rim of the ring...
June 12, 2017: International Ophthalmology
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