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Wound dressings

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https://www.readbyqxmd.com/read/29665712/nocardia-rubra-cell-wall-skeleton-accelerates-cutaneous-wound-healing-by-enhancing-macrophage-activation-and-angiogenesis
#1
Yi Wang, Ying Hu, Ben Ma, Fei Wang, Sheng Liu, Jing Xu, Xu-Lin Chen, Xiong-Wen Lü
Objective This study was performed to investigate the effect of Nocardia rubra cell wall skeleton (N-CWS) on wound healing of full-thickness skin defects. Methods Two 2- × 2-cm full-thickness wounds, one on each side of the midline, were made on the back of 12 rats. One wound was covered with Vaseline gauze soaked in normal saline, whereas the other was covered with Vaseline gauze and N-CWS. Wound dressings were changed every other day from day 0 (wound creation) to day 11. Four of the 12 rats were killed on day 7, and biopsy samples were obtained for biochemical and histopathological analyses...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29665678/lectin-functionalized-composite-hydrogels-for-capture-and-killing-of-carbapenem-resistant-pseudomonas-aeruginosa
#2
Nicholas Bodenberger, Dennis Kubiczek, Daniel Halbgebauer, Vittoria Rimola, Sebastian Wiese, Daniel Mayer, Armando Alexei Rodr Iacute Guez Alfonso, Ludger Ständker, Steffen Stenger, Frank Rosenau
Infections with multi-resistant pathogens are a leading cause for mortality worldwide. Just recently, the world health organization (WHO) increased the threat rating for multi-resistant Pseudomonas aeruginosa to the highest possible level. With this background it is crucial to develop novel materials and procedures in the fight against multi-resistant pathogens. In this study we present a novel antimicrobial material, which could find applications as a wound dressing or antimicrobial coating. Lectins are multivalent sugar-binding proteins, which can be found in a variety of plants and bacteria, where they are associated with biofilm formation...
April 17, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29665285/hemostatic-and-absorbent-polyhipe-kaolin-composites-for-3d-printable-wound-dressing-materials
#3
Benjamin C Streifel, Jeffrey G Lundin, Allix M Sanders, Karli A Gold, Thomas S Wilems, Sierra J Williams, Elizabeth Cosgriff-Hernandez, James H Wynne
A novel hemostatic and absorbent wound dressing material compatible with 3D printing is developed to address deficiencies in current wound dressing protocol. The design involves an open celled, microporous hydrogel foam via a high internal phase emulsion (HIPE) template with biocompatible components and tunable hemostatic character by kaolin loading, the viscosity and cure kinetics of which are tailored for 3D printing applications. The use of nontoxic mineral oil organic phase results in cytocompatability with human dermal fibroblasts...
April 17, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29664827/skin-graft-fixation-using-hydrofiber-aquacel%C3%A2-extra
#4
Ya-Hui Yen, Chih-Ming Lin, Honda Hsu, Ying-Chen Chen, Yi-Wen Chen, Wan-Yu Li, Chia-Nan Hsieh, Chieh-Chi Huang
BACKGROUND: The traditional method of skin graft fixation is with tie-over bollus dressing. The use of splints in the extremities for skin graft fixation is a common practice. However, these splints are heavy and uncomfortable and contribute considerably to our overall medical waste. Hydrofiber (Aquacel Extra) has a strong fluid absorption property and fixates well to the underlying wound once applied. In this study, we used hydrofiber for fixation, avoiding the use of splints after skin grafting...
April 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29663928/a-tiered-experimental-approach-for-characterization-and-silver-release-of-silver-containing-wound-dressings
#5
Liming Xu, Ru Bai, Xiang Cheng, Anliang Shao, Liang Chen, Shuxin Qu, Chunying Chen
Silver-containing dressings are widely used for wound care owing to their broad-spectrum microbicidal activity. However, the potential adverse effects on human health emerging from exposure to their active ingredients (silver ions or nanoparticles) have resulted in widespread concerns about their use. The release profiles of various chemical forms of silver (Ag) from silver-containing dressing are closely related to their bioavailability and potential adverse effects on the body. In this research, we demonstrated a tiered experimental approach for systematic characterization and assessment of silver-containing wound dressing, which provides information for risk assessments...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29663607/dynamic-interfacial-adhesion-through-cucurbit-n-uril-molecular-recognition
#6
Ji Liu, Cindy Soo Yun Tan, Oren A Scherman
Supramolecular building block, such as cucurbit[n]uril (CB[n])-based host-guest complexes, have been extensively studied at the nano- and microscale as adhesion promoters. Herein, we exploit a new class of CB[n]-threaded highly-branched polyrotaxanes (HBP-CB[n]) as aqueous adhesives to macroscopically bond two wet surfaces, including biological tissue, through the formation of CB[8] heteroternary complexes. The dynamic nature of these complexes gives rise to adhesion with remarkable self-healing, displaying recovery and re-adhesion after mechanical failure at the interface...
April 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29656131/postoperative-treatment-following-open-incisional-hernia-repair-a-survey-and-a-review-of-literature
#7
Christoph Paasch, Stefan Anders, Martin W Strik
INTRODUCTION: Incisional hernias of the abdominal wall are frequent complication after laparotomy (9-20%). Open incisional hernia repair with sublay mesh placement (SMP) on the posterior rectus sheath is described as being a sufficient method for repairing incisional hernia. In order to ensure wound healing and to therefore prevent recurrence, carrying an abdominal binder (AB) or a pressure dressing (PD) and physical rest for a certain time is the common postoperative recommendation, though the evidence for post-operative treatment is low...
April 12, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29655798/a-potential-antibacterial-wound-dressing-of-cefadroxil-chitosan-nanoparticles-in-situ-gel-fabrication-in-vitro-optimization-and-in-vivo-evaluation
#8
Mona Basha, Mona M AbouSamra, Ghada A Awad, Soheir S Mansy
Wound healing following skin injury is a natural phenomenon that usually lacks quality, rapidity, and aesthetics. Thus, the purpose of this study was to fabricate a new easily applied in situ gel of Cefadroxil (CDX) loaded with chitosan nanoparticles (CDX-CSNPs) that could promote wound healing, capable of inhibiting the possible accompanying bacterial infection. The nanoparticles were prepared by double emulsion technique and the influence of formulation parameters on drug entrapment efficiency (EE%), particle size (PS), polydispersity index (PDI) and zeta potential (ZP) were investigated using a full factorial design...
April 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29652825/fabrication-of-sericin-agrose-gel-loaded-lysozyme-and-its-potential-in-wound-dressing-application
#9
Meirong Yang, Yejing Wang, Gang Tao, Rui Cai, Peng Wang, Liying Liu, Lisha Ai, Hua Zuo, Ping Zhao, Ahmad Umar, Chuanbin Mao, Huawei He
Sericin is a biomaterial resource for its significant biodegradability, biocompatibility, hydrophilicity, and reactivity. Designing a material with superabsorbent, antiseptic, and non-cytotoxic wound dressing properties is advantageous to reduce wound infection and promote wound healing. Herein, we propose an environment-friendly strategy to obtain an interpenetrating polymer network gel through blending sericin and agarose and freeze-drying. The physicochemical characterizations of the sericin/agarose gel including morphology, porosity, swelling behavior, crystallinity, secondary structure, and thermal property were well characterized...
April 13, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29651952/special-traumatized-populations-burns-and-hypothermia
#10
Shruti Mehrotra, Amita Misir
It is important for physicians treating children to be aware of unique presentation that require expertise and knowledge. Two areas of importance when caring for traumatized children are Thermal Burn Injuries, and Hypothermia. Burns commonly result in morbidity in children; as such, the appropriate identification of the severity of the burn and appropriate management are integral to minimize the complications of burns during the acute phase. Attention to proper fluid management is paramount. Knowledge of types of solutions to use during Burn treatment is important...
April 11, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29651394/the-healing-effect-of-sesame-oil-camphor-and-honey-on-second-degree-burn-wounds-in-rat
#11
Reza Vaghardoost, Seyed GholamReza Mousavi Majd, Hamid Tebyanian, Hamid Babavalian, Leila Malaei, Mitra Niazi, Ali Javdani
BACKGROUND: Many studies were carried out to improve sophisticated dressings to accelerate healing processes and reduce the microbial burden in burn wounds. This study evaluated the healing effect of herbal ointment containing extract of sesame oil, camphor and honey on second degree burn wounds in rats in comparison with daily dressing oil vaseline. METHODS: Forty rats were randomly assigned to two equal groups. A deep second degree burn was formed on the back of each rat with using a standard burning technique...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29651393/wound-healing-potential-of-intermittent-negative-pressure-under-limited-access-dressing-in-burn-patients-biochemical-and-histopathological-study
#12
Honnegowda Thittamaranahalli Muguregowda, Pramod Kumar, Padmanabha Udupa Echalasara Govindarama
BACKGROUND: Malondialdehyde (MDA) is an oxidant that causes damage to membranes, DNA, proteins, and lipids at the cellular level. Antioxidants minimize the effects of oxidants and thus help in formation of healthy granulation tissues with higher level of hydroxyproline and total protein. This study compared the effect of limited access dressing (LAD) with conventional closed dressing biochemically and histopathologically. METHODS: Seventy-two 12-65 years old burn patients with mean wound size of 14 cm2 were divided to two groups of LAD (n=37), and conventional dressing groups (n=35)...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29649056/topical-aloe-vera-gel-for-accelerated-wound-healing-of-split-thickness-skin-graft-donor-sites-a-double-blind-randomized-controlled-trial-and-systematic-review
#13
Chairat Burusapat, Monlada Supawan, Chatchai Pruksapong, Anont Pitiseree, Chaichoompol Suwantemee
BACKGROUND: Aloe vera has been used to treat wounds since ancient times. However, the efficacy of Aloe vera for burns and split-thickness skin graft (STSG) donor sites are inconclusive. METHODS: A double-blind, randomized, controlled trial was conducted. Patients who underwent STSG harvesting from the thigh were included. STSG donor sites were divided into two groups: Aloe vera group and placebo group. The visual analogue scale (VAS) score evaluated pain and complete epithelialization was assessed...
March 30, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29644297/negative-pressure-in-treatment-of-persistent-post-traumatic-subcutaneous-emphysema-with-respiratory-failure-case-report-and-literature-review
#14
Jakov Mihanović, Ivan Bačić, Nina Sulen
Subcutaneous emphysema may aggravate traumatic pneumothorax treatment, especially when mechanical ventilation is required. Expectative management usually suffices, but when respiratory function is impaired surgical treatment might be indicated. Historically relevant methods are blowhole incisions and placement of various drains, often with related wound complications. Since the first report of negative pressure wound therapy for the treatment of severe subcutaneous emphysema in 2009, only few publications on use of commercially available sets were published...
February 2018: Trauma Case Reports
https://www.readbyqxmd.com/read/29628695/medical-textiles-in-orthopedics-an-overview
#15
REVIEW
Raju Vaishya, Amit Kumar Agarwal, Manish Tiwari, Abhishek Vaish, Vipul Vijay, Yash Nigam
The use of textile in the medical field is not new; this has given rise to a new branch known as medical textiles. These are being used to repair or replace various other musculoskeletal tissues. The most common uses of biomaterials are to create aseptic conditions for protection, general health care, and hygiene including bedding and clothing, surgical gowns, face masks, head and shoe covers, sterilization wraps, suture anchors, fiber cast and braces/orthotics. These are also used as materials for preparation of wipes, swabs, wound dressings, bandages, gauzes, plasters, pressure garments, orthopedic belts and for new applications, such as heart valves, vascular grafts, artificial veins, artificial ligaments, artificial joints, artificial skin, and artificial cartilage...
March 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29628671/scrotal-reconstruction-with-integra-following-necrotizing-fasciitis
#16
Briar L Dent, Anant Dinesh, Khuram Khan, Ryan Engdahl
Scrotal loss from Fournier's gangrene can be a devastating injury with esthetic and functional consequences. Local reconstructive options can be limited by the presence of infection or the loss of neighboring tissue from debridement. IntegraTM bilayer matrix wound dressing is a well-established reconstructive modality, but only one report exists of its use in scrotal reconstruction and this was not in the setting of Fournier's gangrene. We report the successful use of Integra and a subsequent split-thickness skin graft for reconstruction of the anterior scrotum and coverage of the exposed testes in a 43-year-old man who developed Group A Streptococcus necrotizing fasciitis of his right lower extremity, groin, and scrotum requiring serial operative debridements...
January 2018: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/29628252/processing-and-antibacterial-properties-of-chitosan-coated-alginate-fibers
#17
Mélanie Dumont, Régis Villet, Manon Guirand, Alexandra Montembault, Thierry Delair, Stéphane Lack, Michel Barikosky, Agnès Crepet, Pierre Alcouffe, Frédéric Laurent, Laurent David
The preparation of chitosan-coated alginate fibers by a wet spin process is presented and the characterization of the antibacterial activities of these fibers is discussed. Preformed calcium alginate fibers were passed in chitosan acetate solutions. The coagulation method of the coating consisted in the immersion of fibers in a bath of calcium dihydroxide solution (0.1 M). The antibacterial evaluation was achieved by a CFU (Colony-Forming Units) counting method after 6 h of incubation at 37 °C. The incorporation of chitosan on calcium alginate fibers brings antibacterial activities against Staphylococcus epidermidis, Escherichia coli and various Staphylococcus aureus strains namely MSSA (Methicillin Sensitive Staphylococcus aureus), CA-MRSA (Community Associated Methicillin Resistant Staphylococcus aureus) and HA-MRSA (Healthcare Associated Methicillin Resistant Staphylococcus aureus) which make these chitosan-coated fibers potential candidates for wound dressing materials...
June 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29627463/recent-advances-on-silver-nanoparticle-and-biopolymer-based-biomaterials-for-wound-healing-applications
#18
REVIEW
Sathish Sundar Dhilip Kumar, Naresh Kumar Rajendran, Nicolette Nadene Houreld, Heidi Abrahamse
Silver nanoparticles (AgNPs) are classified as metal-based nanoparticles and have gained considerable attention amongst researchers in wound healing applications, owing to their physicochemical and biological properties. The effectiveness of AgNPs has been tested in vitro and are well documented in the literature. Silver nanoparticles have been shown to possess fast, broad-spectrum antibacterial activity. Dressings which contain AgNPs are non-cytotoxic and safe for patients in wound care management. Silver nanoparticle based biomaterials (AgNP-BMs) are actively utilized for the treatment of all types of chronic wounds, and this combination plays an important role in wound healing applications...
April 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29627131/treatment-of-toxic-epidermal-necrolysis-by-a-multidisciplinary-team-a-review-of-literature-and-treatment-results
#19
Anthony Papp, Sheena Sikora, Morgan Evans, Diana Song, Mark Kirchhof, Monica Miliszewski, Jan Dutz
BACKGROUND: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are mucocutaneous hypersensitivity reactions, usually to drugs or their metabolites. TEN is the most severe involving greater than 30% of the total body surface area (TBSA). Management of these patients usually benefits from a large multidisciplinary team for both wound and medical management. Treatment of these patients varies between centers and physicians and there is lack of a standardized treatment protocol in the medical literature...
April 4, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29622085/l-inermis-loaded-nanofibrous-scaffolds-for-wound-dressing-applications
#20
Saeid Vakilian, Mohammad Norouzi, Mahsa Soufi-Zomorrod, Iman Shabani, Simzar Hosseinzadeh, Masoud Soleimani
Since ancient times, some herbal medicines have been extensively used for burn and wound treatments, showing preference to the common synthetic medications by virtue of having less side effects and faster healing rate. In this study, hybrid nanofibrous scaffolds of poly-l-lactic-acid (PLLA) and gelatin incorporated L. inermis were fabricated via electrospinning technique. Morphology and characteristics of the scaffolds were studied by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR), respectively...
April 2018: Tissue & Cell
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