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Rotavirus immune response

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https://www.readbyqxmd.com/read/29762363/immunogenicity-and-safety-of-primary-and-booster-vaccinations-of-a-fully-liquid-dtap-ipv-hb-prp-t-hexavalent-vaccine-in-healthy-infants-and-toddlers-in-germany-and-the-czech-republic
#1
Roman Prymula, Dorothee Kieninger, Emmanuel Feroldi, Emilia Jordanov, Siham B'Chir, Xavier DaCosta
BACKGROUND: To support a fully liquid, diphtheria (D)-tetanus (T)-acellular pertussis (aP)-inactivated poliovirus (IPV)-hepatitis B (HB)-Haemophilus influenzae b (PRP-T) vaccine in Europe using a 2, 3, 4 month primary series and a booster at 11 to 15 months of age. METHODS: Phase III, randomized, observer-blind studies in Germany and the Czech Republic. Participants who had not received HB vaccine were randomized to a 2, 3, 4 month primary series of DTaP-IPV-HB-PRP-T (Group 1; N=266) or a reconstituted DTaPHB-IPV//PRP-T comparator (Group 2; N=263) and a booster of the same vaccine...
May 14, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29757386/impact-of-vaccine-stock-outs-on-infant-vaccination-coverage-a-hospital-based-survey-from-south-africa
#2
Rosemary J Burnett, Gloria Mmoledi, Ntombenhle J Ngcobo, Carine Dochez, L Mapaseka Seheri, M Jeffrey Mphahlele
Introduction: National population-based immunization coverage surveys provide data for validating official administrative coverage figures. However, these costly and logistically challenging surveys are conducted infrequently. This hospital-based records review determined coverage of birth-dose vaccines, fully immunized under 1-y-old coverage (FIC) of 12- to 59-mo-old children; and the reasons for missed vaccinations. Methods: Rotavirus surveillance in South Africa is based on under-5-y-old children being treated for diarrhoea, and includes photocopying the official vaccination document and collecting data on reasons for missed vaccinations...
May 11, 2018: International Health
https://www.readbyqxmd.com/read/29736406/immune-response-to-rotavirus-and-gluten-sensitivity
#3
Antonio Puccetti, Daniele Saverino, Roberta Opri, Oretta Gabrielli, Giovanna Zanoni, Andrea Pelosi, Piera Filomena Fiore, Francesca Moretta, Claudio Lunardi, Marzia Dolcino
Rotavirus is a double-stranded RNA virus belonging to the family of Reoviridae . The virus is transmitted by the faecal-oral route and infects intestinal cells causing gastroenteritis. Rotaviruses are the main cause of severe acute diarrhoea in children less than 5 years of age worldwide. In our previous work we have shown a link between rotavirus infection and celiac disease. Nonceliac gluten sensitivity (NCGS) is emerging as new clinical entity lacking specific diagnostic biomarkers which has been reported to occur in 6-10% of the population...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29709097/autophagy-the-multi-purpose-bridge-in-viral-infections-and-host-cells
#4
REVIEW
Asghar Abdoli, Mehrdad Alirezaei, Parvaneh Mehrbod, Faezeh Forouzanfar
Autophagy signaling pathway is involved in cellular homeostasis, developmental processes, cellular stress responses, and immune pathways. The aim of this review is to summarize the relationship between autophagy and viruses. It is not possible to be fully comprehensive, or to provide a complete "overview of all viruses". In this review, we will focus on the interaction of autophagy and viruses and survey how human viruses exploit multiple steps in the autophagy pathway to help viral propagation and escape immune response...
April 30, 2018: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29708975/high-prevalence-of-g3-rotavirus-in-hospitalized-children-in-rawalpindi-pakistan-during-2014
#5
Massab Umair, Bilal Haider Abbasi, Salmaan Sharif, Muhammad Masroor Alam, Muhammad Suleman Rana, Ghulam Mujtaba, Yasir Arshad, M Qaiser Fatmi, Sohail Zahoor Zaidi
Rotavirus A species (RVA) is the leading cause of severe diarrhea among children in both developed and developing countries. Among different RVA G types, humans are most commonly infected with G1, G2, G3, G4 and G9. During 2003-2004, G3 rotavirus termed as "new variant G3" emerged in Japan that later disseminated to multiple countries across the world. Although G3 rotaviruses are now commonly detected globally, they have been rarely reported from Pakistan. We investigated the genetic diversity of G3 strains responsible RVA gastroenteritis in children hospitalized in Rawalpindi, Pakistan during 2014...
2018: PloS One
https://www.readbyqxmd.com/read/29670610/neonatal-immunization-rationale-current-state-and-future-prospects
#6
REVIEW
Elizabeth Whittaker, David Goldblatt, Peter McIntyre, Ofer Levy
Infections take their greatest toll in early life necessitating robust approaches to protect the very young. Here, we review the rationale, current state, and future research directions for one such approach: neonatal immunization. Challenges to neonatal immunization include natural concern about safety as well as a distinct neonatal immune system that is generally polarized against Th1 responses to many stimuli such that some vaccines that are effective in adults are not in newborns. Nevertheless, neonatal immunization could result in high-population penetration as birth is a reliable point of healthcare contact, and offers an opportunity for early protection of the young, including preterm newborns who are deficient in maternal antibodies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29662124/stag2-deficiency-induces-interferon-responses-via-cgas-sting-pathway-and-restricts-virus-infection
#7
Siyuan Ding, Jonathan Diep, Ningguo Feng, Lili Ren, Bin Li, Yaw Shin Ooi, Xin Wang, Kevin F Brulois, Linda L Yasukawa, Xingnan Li, Calvin J Kuo, David A Solomon, Jan E Carette, Harry B Greenberg
Cohesin is a multi-subunit nuclear protein complex that coordinates sister chromatid separation during cell division. Highly frequent somatic mutations in genes encoding core cohesin subunits have been reported in multiple cancer types. Here, using a genome-wide CRISPR-Cas9 screening approach to identify host dependency factors and novel innate immune regulators of rotavirus (RV) infection, we demonstrate that the loss of STAG2, an important component of the cohesin complex, confers resistance to RV replication in cell culture and human intestinal enteroids...
April 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29656244/human-organoid-cultures-transformative-new-tools-for-human-virus-studies
#8
REVIEW
Sasirekha Ramani, Sue E Crawford, Sarah E Blutt, Mary K Estes
Studies of human infectious diseases have been limited by the paucity of functional models that mimic normal human physiology and pathophysiology. Recent advances in the development of multicellular, physiologically active organotypic cultures produced from embryonic and pluripotent stem cells, as well as from stem cells isolated from biopsies and surgical specimens are allowing unprecedented new studies and discoveries about host-microbe interactions. Here, we summarize recent developments in the use of organoids for studying human viral pathogens, including intestinal infections with human rotavirus, norovirus, enteroviruses and adenoviruses (intestinal organoids and enteroids), neuronal infections with Zika virus (cerebral organoids) and respiratory infections with respiratory syncytial virus in (lung bud organoids)...
April 2018: Current Opinion in Virology
https://www.readbyqxmd.com/read/29621276/rotavirus-intestinal-infection-induces-an-oral-mucosa-cytokine-response
#9
José Gómez-Rial, María José Curras-Tuala, Irene Rivero-Calle, Carmen Rodríguez-Tenreiro, Lorenzo Redondo-Collazo, Alberto Gómez-Carballa, Jacobo Pardo-Seco, Antonio Salas, Federico Martinón-Torres
INTRODUCTION: Salivary glands are known immune effector sites and considered to be part of the whole mucosal immune system. The aim of the present study was to assess the salivary immune response to rotavirus (RV) infection through the analysis of the cytokine immune profile in saliva. MATERIAL AND METHODS: A prospective comparative study of serial saliva samples from 27 RV-infected patients (sampled upon admission to the hospital during acute phase and at convalescence-i...
2018: PloS One
https://www.readbyqxmd.com/read/29560435/antibody-secreting-b-cells-and-plasma-antibody-response-to-rotavirus-vaccination-in-infants-from-kolkata-india
#10
Anuradha Sinha, Suman Kanungo, Deok Ryun Kim, Byomkesh Manna, Manki Song, Ju Yeon Park, Bisakha Haldar, Prashant Sharma, Aiyel Haque Mallick, Soon Ae Kim, Sudhir Babji, Dipika Sur, Gagandeep Kang, Mohammad Ali, William A Petri, Thomas F Wierzba, Cecil Czerkinsky, Ranjan Kumar Nandy, Ayan Dey
Background: Assessing immune response after rotavirus vaccination consists in measuring serum or plasma IgA and IgG antibodies, but these assays provide very little information about the mucosal immune response. Thus the development of assays for detection of mucosal immune response following rotavirus vaccination is essential. We evaluate to assess circulating antibody-secreting cells (ASCs) as a potential means to evaluate mucosal immune responses to rotavirus vaccine. Methods: 372 subjects, aged 6 weeks, were enrolled in the study...
January 2018: Heliyon
https://www.readbyqxmd.com/read/29555220/expression-and-characterization-of-a-novel-truncated-rotavirus-vp4-for-the-development-of-a-recombinant-rotavirus-vaccine
#11
Yijian Li, Miaoge Xue, Linqi Yu, Guoxing Luo, Han Yang, Lianzhi Jia, Yuanjun Zeng, Tingdong Li, Shengxiang Ge, Ningshao Xia
The outer capsid protein VP4 is an important target for the development of a recombinant rotavirus vaccine because it mediates the attachment and penetration of rotavirus. Due to the poor solubility of full-length VP4, VP8 was explored as candidate rotavirus vaccines in the past years. In previous studies, it has been found that the N-terminal truncated VP8 protein, VP8-1 (aa26-231), could be expressed in soluble form with improved immunogenicity compared to the core of VP8 (aa65-223). However, this protein stimulated only a weak immune response when aluminum hydroxide was used as an adjuvant...
March 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29543547/a-phase-4-multicentre-randomized-single-blind-clinical-trial-to-evaluate-the-immunogenicity-of-the-live-attenuated-oral-rotavirus-vaccine-116e-rotavac%C3%A2-administered-simultaneously-with-or-without-the-buffering-agent-in-healthy-infants-in-india
#12
Raches Ella, Radhika Bobba, Sanjay Muralidhar, Sudhir Babji, Krishna Mohan Vadrevu, Maharaj Kishan Bhan
BACKGROUND: The World Health Organization recommends that rotavirus vaccines should be included in all national immunization programs. Some currently licensed oral rotavirus vaccines contain a buffering agent (either as part of a ready-to-use liquid formulation or added during reconstitution) to reduce possible degradation of the vaccine virus in the infant gut, which poses several programmatic challenges (the large dose volume or the reconstitution requirement) during vaccine administration...
March 15, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29496429/evaluation-of-the-immunogenicity-of-a-recombinant-hsv-1-vector-expressing-human-group-c-rotavirus-vp6-protein
#13
Rosana P Rota, Carlos A Palacios, C Facundo Temprana, Marcelo H Argüelles, Marcelo G Mandile, Nora Mattion, Andrea S Laimbacher, Cornell Fraefel, Alejandro A Castello, Graciela Glikmann
Group C Rotavirus (RVC) has been associated globally with sporadic outbreaks of gastroenteritis in children and adults. RVC also infects animals, and interspecies transmission has been reported as well as its zoonotic potential. Considering its genetic diversity and the absence of effective vaccines, it is important and necessary to develop new generation vaccines against RVC for both humans and animals. The aim of the present study was to develop and characterize an HSV-1-based amplicon vector expressing a human RVC-VP6 protein and evaluate the humoral immune response induced after immunizing BALB/c mice...
June 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29475500/generation-of-murine-monoclonal-antibodies-with-specificity-against-conventional-camelid-igg1-and-heavy-chain-only-igg2-3
#14
Pamela Holzlöhner, Monique Butze, Natalia Maier, Nicole Hebel, Erik Schliebs, Burkhard Micheel, Jonas Füner, Gabriele Heidicke, Katja Hanack
Camelids possess antibodies with a conventional four-chain structure consisting of two heavy and two light chains (of subclass IgG1) but further they also generate heavy-chain only antibodies (of subclass IgG2 and 3) which are fully functional in antigen binding. In this study subclass-specific murine monoclonal antibodies specific to conventional camelid IgG1 and heavy-chain only IgG2/3 were generated and validated for the use as potent secondary detection reagents. The monoclonal antibodies are able to differentiate between all camelid IgGs, conventional four-chain camelid antibodies (of subclass IgG1) and exclusively heavy chain-only antibodies (of subclasses IgG2 and IgG3)...
March 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29466421/protective-effects-and-immunomodulation-on-piglets-infected-with-rotavirus-following-resveratrol-supplementation
#15
Qiankun Cui, Qiuting Fu, Xinghong Zhao, Xu Song, Jiankang Yu, Yi Yang, Kai Sun, Lu Bai, Ye Tian, Shufan Chen, Renyong Jia, Yuanfeng Zou, Lixia Li, Xiaoxia Liang, Changliang He, Lizi Yin, Gang Ye, Cheng Lv, Guizhou Yue, Zhongqiong Yin
Rotavirus (RV), belonging to Reoviridae family, is the leading cause of acute severe viral diarrhea in children (under 5 years old) and infant animals worldwide. Although vaccines are commonly used to prevent infection, episodes of diarrhea caused by RV frequently occur. Thus, this study was conducted to determine whether resveratrol had protective effects against RV infection in piglets. Following pretreatment with resveratrol dry suspension through adding into the basal diet for 3 weeks, the piglets were orally challenged with RV...
2018: PloS One
https://www.readbyqxmd.com/read/29466164/human-neonatal-rotavirus-vaccine-rv3-bb-to-target-rotavirus-from-birth
#16
RANDOMIZED CONTROLLED TRIAL
Julie E Bines, Jarir At Thobari, Cahya Dewi Satria, Amanda Handley, Emma Watts, Daniel Cowley, Hera Nirwati, James Ackland, Jane Standish, Frances Justice, Gabrielle Byars, Katherine J Lee, Graeme L Barnes, Novilia S Bachtiar, Ajeng Viska Icanervilia, Karen Boniface, Nada Bogdanovic-Sakran, Daniel Pavlic, Ruth F Bishop, Carl D Kirkwood, Jim P Buttery, Yati Soenarto
BACKGROUND: A strategy of administering a neonatal rotavirus vaccine at birth to target early prevention of rotavirus gastroenteritis may address some of the barriers to global implementation of a rotavirus vaccine. METHODS: We conducted a randomized, double-blind, placebo-controlled trial in Indonesia to evaluate the efficacy of an oral human neonatal rotavirus vaccine (RV3-BB) in preventing rotavirus gastroenteritis. Healthy newborns received three doses of RV3-BB, administered according to a neonatal schedule (0 to 5 days, 8 weeks, and 14 weeks of age) or an infant schedule (8 weeks, 14 weeks, and 18 weeks of age), or placebo...
February 22, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29377961/shared-and-organism-specific-host-responses-to-childhood-diarrheal-diseases-revealed-by-whole-blood-transcript-profiling
#17
Hannah A DeBerg, Mussaret B Zaidi, Matthew C Altman, Prasong Khaenam, Vivian H Gersuk, Freddy D Campos, Iza Perez-Martinez, Mario Meza-Segura, Damien Chaussabel, Jacques Banchereau, Teresa Estrada-Garcia, Peter S Linsley
Globally, diarrheal diseases are a leading cause of death in children under five and disproportionately affect children in developing countries. Children who contract diarrheal diseases are rarely screened to identify the etiologic agent due to time and cost considerations associated with pathogen-specific screening and hence pathogen-directed therapy is uncommon. The development of biomarkers to rapidly identify underlying pathogens could improve treatment options and clinical outcomes in childhood diarrheal diseases...
2018: PloS One
https://www.readbyqxmd.com/read/29336924/immunization-of-preterm-infants-with-gsk-s-hexavalent-combined-diphtheria-tetanus-acellular-pertussis-hepatitis-b-inactivated-poliovirus-haemophilus-influenzae-type-b-conjugate-vaccine-a-review-of-safety-and-immunogenicity
#18
Felix Omeñaca, Liliana Vázquez, Pilar Garcia-Corbeira, Narcisa Mesaros, Linda Hanssens, Jan Dolhain, Ivonne Puente Gómez, Johannes Liese, Markus Knuf
BACKGROUND: Infants with history of prematurity (<37 weeks gestation) and low birth weight (LBW, <2500 g) are at high risk of infection due to functional immaturity of normal physical and immunological defense mechanisms. Despite current recommendations that infants with history of prematurity/LBW should receive routine immunization according to the same schedule and chronological age as full-term infants, immunization is often delayed. METHODS: Here we summarize 10 clinical studies and 15 years of post-marketing safety surveillance of GSK's hexavalent vaccine (DTPa-HBV-IPV/Hib), a combined diphtheria-tetanus-acellular-pertussis-hepatitis-B-inactivated-poliovirus-Haemophilus influenzae-type-b (Hib) conjugate vaccine, when administered alone, or co-administered with pneumococcal conjugate, rotavirus, and meningococcal vaccines and respiratory syncytial virus IgG to infants with history of prematurity/LBW in clinical trials...
February 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29330512/inactivated-rotavirus-vaccine-by-parenteral-administration-induces-mucosal-immunity-in-mice
#19
Theresa K Resch, Yuhuan Wang, Sung-Sil Moon, Jessica Joyce, Song Li, Mark Prausnitz, Baoming Jiang
To improve the safety and efficacy of oral rotavirus vaccines, we developed an inactivated rotavirus vaccine (IRV) for parenteral administration. Since it remains unknown whether parenteral vaccination can induce mucosal immunity, we performed a comprehensive assessment of immune responses to IRV in mice with an adjuvant-free dissolving polymer MN patch or by alum-adjuvanted IM injection. We demonstrated that IRV induced the expression of the gut homing receptor LPAM-1 on T and B cells in spleen and mLN of vaccinated mice...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29290097/challenges-in-developing-mucosal-vaccines-and-antibodies-against-infectious-diarrhea-in-children
#20
REVIEW
Daisuke Tokuhara
Infectious diarrhea in children can be life-threatening and imposes a large economic burden on healthcare systems, therefore more effective prophylactic and therapeutic drugs are needed urgently. Because most of the pathogens responsible for childhood diarrhea infect the gastrointestinal mucosa, providing protective immunity at the mucosal surface is an ideal way to control pathogen invasion and toxic activity. Mucosal (e.g. oral, nasal) vaccines are superior to systemic (subcutaneous or intramuscular) vaccination for conferring both mucosal and systemic pathogen-specific immune responses...
March 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
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