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https://www.readbyqxmd.com/read/28318118/distinct-expression-of-nk2-homeobox-1-nkx2-1-and-goblet-cell-hyperplasia-in-nasal-polyps-with-different-endotypes
#1
Jintao Du, Luo Ba, Bo Li, Feng Liu, Xianting Hu, Jie Zhang, Yafeng Liu, Junming Xian, Sixi Liu, Huabin Li
BACKGROUND: Decreased expression of airway epithelial-specific transcription factor NK2 homeobox 1 (NKX2-1) was associated with allergic inflammation in asthma patients. However, the expression and role of NKX2-1 in nasal polyps (NPs) with different endotypes were undefined yet. METHODS: We examined the expression of key cytokines (interleukin [IL]-4 IL-5, IL-13, and IL-17A, etc.) and NKX2-1 in NPs with different endotypes and control tissues by immunohistochemistry staining, qualitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA), and Western blot analysis...
March 20, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28303416/microrna-24-modulates-staphylococcus-aureus-induced-macrophage-polarization-by-suppressing-chi3l1
#2
Zhang Jingjing, Zhang Nan, Wu Wei, Guo Qinghe, Wang Weijuan, Wang Peng, Wang Xiangpeng
Macrophages play a crucial role in host innate anti-Staphylococcus aureus defense, which is tightly regulated by multiple factors, including microRNAs. A recent study showed that miR-24 plays an important role in macrophage polarization. Here, we investigated the biological function of miR-24 in S. aureus-stimulated macrophages. The results revealed that miR-24 expression was significantly decreased in both human and mouse macrophage cell lines with S. aureus stimulation in a time-dependent manner. Moreover, miR-24 overexpression significantly decreased the production of M1 phenotype markers, such as IL-6, iNOS, TNF-α, CD86, and CD80, whereas it increased the production of M2 markers, such as Arg1, CCL17, CCL22, CD163, and CD206, in S...
March 16, 2017: Inflammation
https://www.readbyqxmd.com/read/28274317/-changes-of-trgv-genes-and-prognosis-related-chemokine-receptor-gene-expressions-in-t-cell-lymphoma
#3
Qiang Luo, Zhenyi Jin, Shaohua Chen, Lijian Yang, Bo Li, Wenyu Li, Yangqiu Li, Xiuli Wu
Objective To analyze the expressions of T cell receptor γ subfamily variable region I, II, and III genes (TRGV I~III) and prognosis-related chemokines and their receptor genes (CCL20, CCR6, CCL17, CCL22 and CCR4) in the peripheral blood of T-cell lymphoma (non-γδ T cell type) patients, and to investigate the correlations between γδ T cells and chemokines/receptors and their relevance to disease prognosis. Methods Peripheral blood samples were collected from 27 patients with T-cell lymphoma (non-γδ T cell type) and 9 healthy individuals as controls...
March 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28245601/distinct-antigen-delivery-systems-induce-dendritic-cells-divergent-transcriptional-response-new-insights-from-a-comparative-and-reproducible-computational-analysis
#4
Valerio Costa, Dario Righelli, Francesco Russo, Piergiuseppe De Berardinis, Claudia Angelini, Luciana D'Apice
Vaccination is the most successful and cost-effective method to prevent infectious diseases. However, many vaccine antigens have poor in vivo immunogenic potential and need adjuvants to enhance immune response. The application of systems biology to immunity and vaccinology has yielded crucial insights about how vaccines and adjuvants work. We have previously characterized two safe and powerful delivery systems derived from non-pathogenic prokaryotic organisms: E2 and fd filamentous bacteriophage systems. They elicit an in vivo immune response inducing CD8+ T-cell responses, even in absence of adjuvants or stimuli for dendritic cells' maturation...
February 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28240436/the-ccl17-ccr4-axis-between-endometrial-stromal-cells-and-macrophages-contributes-to-the-high-levels-of-il-6-in-ectopic-milieu
#5
Wen-Jie Zhou, Xin-Xin Hou, Xiao-Qiu Wang, Da-Jin Li
Endometriosis is a chronic inflammatory disease characterized by the elevation of proinflammatory cytokines, such as IL-6, in the peritoneal fluid. However, the precise mechanism of the highly elevated IL-6 levels in ectopic milieu remains unclear. The aim of this study was to investigate whether the cross talk between endometrial stromal cells (ESCs) and macrophages contributes to the elevated IL-6 production. Samples of endometrium and ectopic tissues were obtained from patients with or without endometriosis...
February 27, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28219704/%C3%AE-lactam-hypersensitivity-involves-expansion-of-circulating-and-skin-resident-th22-cells
#6
Andrew Sullivan, Eryi Wang, John Farrell, Paul Whitaker, Lee Faulkner, Daniel Peckham, B Kevin Park, Dean J Naisbitt
BACKGROUND: β-lactam hypersensitivity has been classified according to the phenotype and function of drug-specific T-cells; however, new T-cell subsets have not been considered. OBJECTIVE: The objective of this study was use piperacillin as a model of β-lactam hypersensitivity to study the nature of the drug-specific T-cell response induced in the blood and skin of hypersensitive patients and healthy volunteers. METHODS: Drug-specific T-cells were cloned from blood and inflamed skin and cellular phenotype and function was explored...
February 17, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28178948/low-ccl17-expression-associates-with-unfavorable-postoperative-prognosis-of-patients-with-clear-cell-renal-cell-carcinoma
#7
Ying Xiong, Li Liu, Yu Xia, Jiajun Wang, Wei Xi, Qi Bai, Yang Qu, Jiejie Xu, Jianming Guo
BACKGROUND: Chemokine (C-C motif) ligand 17 (CCL17) is a chemokine mainly produced by myeloid dendritic cells. It is a ligand for CC chemokine receptor 4 (CCR4) and CC chemokine receptor 8 (CCR8). The aim of this study was to investigate prognostic values of CCL17 expression in patients with clear cell renal cell carcinoma (ccRCC). METHODS: The study included 286 patients with ccRCC. CCL17 expression was analyzed by immunohistochemistry on tissue microarrays. Prognostic values of CCL17 expression and patients' clinical outcomes were evaluated...
February 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28154552/chemokines-associated-with-pathologic-responses-to-orthopedic-implant-debris
#8
REVIEW
Nadim J Hallab, Joshua J Jacobs
Despite the success in returning people to health saving mobility and high quality of life, the over 1 million total joint replacements implanted in the US each year are expected to eventually fail after approximately 15-25 years of use, due to slow progressive subtle inflammation to implant debris compromising the bone implant interface. This local inflammatory pseudo disease state is primarily caused by implant debris interaction with innate immune cells, i.e., macrophages. This implant debris can also activate an adaptive immune reaction giving rise to the concept of implant-related metal sensitivity...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28146427/mir-155-5p-positively-regulates-ccl17-induced-colon-cancer-cell-migration-by-targeting-rhoa
#9
Amr A Al-Haidari, Ingvar Syk, Henrik Thorlacius
Colorectal cancer is the second most common cause of cancer-related death, which is due to migration of tumor cells to distant sites of metastasis. Accumulating data indicate that mciroRNAs play an important role in several aspects of colon cancer cell biology. Herein, we examined the role of miR-155-5p in colon cancer cell migration induced by the CCL17-CCR4 axis in HT-29 colon cancer cells. We found that miR-155-5p knockdown in serum starved colon cancer cells decreased CCL17-induced cell chemotaxis. Moreover, knocking down miR-155-5p markedly decreased CCL17-provoked activation of RhoA in colon cancer cells...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28134623/a-ccr4-antagonist-reverses-the-tumor-promoting-microenvironment-of-renal-cancer
#10
Chiara Berlato, Moddasar N Khan, Tiziana Schioppa, Richard Thompson, Eleni Maniati, Anne Montfort, Maryam Jangani, Monica Canosa, Hagen Kulbe, Urs B Hagemann, Alexander R Duncan, Laura Fletcher, Robert W Wilkinson, Thomas Powles, Sergio A Quezada, Frances R Balkwill
Elevated expression of the chemokine receptor CCR4 in tumors is associated with poor prognosis in several cancers. Here, we have determined that CCR4 was highly expressed in human renal cell carcinoma (RCC) biopsies and observed abnormal levels of CCR4 ligands in RCC patient plasma. An antagonistic anti-CCR4 antibody had antitumor activity in the RENCA mouse model of RCC. CCR4 inhibition did not reduce the proportion of infiltrating leukocytes in the tumor microenvironment but altered the phenotype of myeloid cells, increased NK cell and Th1 cytokine levels, and reduced immature myeloid cell infiltrate and blood chemokine levels...
March 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28119485/plasma-cytokines-and-chemokines-in-zambian-children-with-measles-innate-responses-and-association-with-hiv-1-co-infection-and-in-hospital-mortality
#11
Wen-Hsuan W Lin, Ashley Nelson, Judith J Ryon, William J Moss, Diane E Griffin
To identify immune factors present during the acute rash phase of measles and associations with outcome and HIV-1 co-infection, we measured the plasma levels of 22 cytokines and chemokines in Zambian children hospitalized with measles (N=148) and control children (N=44). Children with measles had higher levels of innate cytokines TNF-α , IL-1β , IL-18 and IL-6; chemokines CCL2, CCL4, CCL11, CCL22, CXCL8 and CXCL10; and T cell cytokines IFN-γ , IL-2, IL-10 and IL-17. Children who died in-hospital had higher levels of TNF-α , IL-1β , IL-12p70; CCL2, CCL4, CCL13, CCL17, CXCL8, CXCL10; IL-2 and IFN-γ and lower levels of IL-4, than children who survived...
January 24, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28111965/identification-of-cd4-t-cell-derived-cd161-cd39-and-cd39-cd73-microparticles-as-new-biomarkers-for-rheumatoid-arthritis
#12
Wenqiang Fan, Wenxiang Wang, Jie Wu, Ling Ma, Jinyan Guo
AIM: This study aimed to identify CD4(+) T-cell-derived microparticles (MPs) and investigate their roles in rheumatoid arthritis (RA). METHODS: Synovial fluids from 34 RA, 33 osteoarthritis patients and 42 healthy individuals were analyzed by flow cytometry. Human fibroblast-like synoviocytes and peripheral blood mononuclear cells were cultured with or without isolated MPs, chemokines and cytokines were measured by ELISA. RESULTS: CD4(+)CD161(+)CD39(+) and CD4(+)CD39(+)CD73(+) MPs were abundantly present in RA patients, which were positively or negatively correlated with RA features, respectively...
February 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28089872/identification-of-airway-mucosal-type-2-inflammation-by-using-clinical-biomarkers-in-asthmatic-patients
#13
Philip E Silkoff, Michel Laviolette, Dave Singh, J Mark FitzGerald, Steven Kelsen, Vibeke Backer, Celeste M Porsbjerg, Pierre-Olivier Girodet, Patrick Berger, Joel N Kline, Geoffrey Chupp, Vedrana S Susulic, Elliot S Barnathan, Frédéric Baribaud, Matthew J Loza
BACKGROUND: The Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study profiled patients with mild, moderate, and severe asthma and nonatopic healthy control subjects. OBJECTIVE: We explored this data set to define type 2 inflammation based on airway mucosal IL-13-driven gene expression and how this related to clinically accessible biomarkers. METHODS: IL-13-driven gene expression was evaluated in several human cell lines. We then defined type 2 status in 25 healthy subjects, 28 patients with mild asthma, 29 patients with moderate asthma, and 26 patients with severe asthma based on airway mucosal expression of (1) CCL26 (the most differentially expressed gene), (2) periostin, or (3) a multigene IL-13 in vitro signature (IVS)...
January 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28039457/tumor-associated-macrophages-promote-prostate-cancer-migration-through-activation-of-the-ccl22-ccr4-axis
#14
Aerken Maolake, Kouji Izumi, Kazuyoshi Shigehara, Ariunbold Natsagdorj, Hiroaki Iwamoto, Suguru Kadomoto, Yuta Takezawa, Kazuaki Machioka, Kazutaka Narimoto, Mikio Namiki, Wen-Jye Lin, Guzailinuer Wufuer, Atsushi Mizokami
Previous studies have found that tumor-associated macrophages (TAMs) promote cancer progression. We previously reported that TAMs promote prostate cancer metastasis via activation of the CCL2-CCR2 axis. The CCR4 (receptor of CCL17 and CCL22) expression level in breast cancer was reported to be associated with lung metastasis. The aim of this study was to elucidate the role of CCR2 and CCR4 in prostate cancer progression. CCR2 and CCR4 were expressed in human prostate cancer cell lines and prostate cancer tissues...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28030356/transcriptional-immune-response-in-mesenteric-lymph-nodes-in-pigs-with-different-levels-of-resistance-to-ascaris-suum
#15
Per Skallerup, Peter Nejsum, Susanna Cirera, Kerstin Skovgaard, Christian B Pipper, Merete Fredholm, Claus B Jørgensen, Stig M Thamsborg
A single nucleotide polymorphism on chromosome 4 (SNP TXNIP) has been reported to be associated with roundworm (Ascaris suum) burden in pigs. The objective of the present study was to analyse the immune response to A. suum mounted by pigs with genotype AA (n = 24) and AB (n = 23) at the TXNIP locus. The pigs were repeatedly infected with A. suum from eight weeks of age until necropsy eight weeks later. An uninfected control group (AA; n = 5 and AB; n = 5) was also included. At post mortem, we collected mesenteric lymph nodes and measured the expression of 28 selected immune-related genes...
March 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/27986411/interleukin-16-and-ccl17-thymus-and-activation-regulated-chemokine-in-patients-with-aspirin-exacerbated-respiratory-disease
#16
Luis Manuel Teran, Fernando Ramirez-Jimenez, Gabriela Soid-Raggi, Juan Raymundo Velazquez
BACKGROUND: Interleukin (IL) 16 and thymus and activation-regulated cytokine (TARC) are chemoattractant cytokines for eosinophils and TH2 cells. Differential levels of these components in aspirin-exacerbated respiratory disease (AERD) and allergic rhinitis with asthma (ARwA) may be related to a different inflammatory response in both asthma phenotypes. OBJECTIVE: To assess the nasal lavage immunoreactivity of IL-16 and TARC cytokines. METHODS: We used multienzyme-linked immunosorbent assays to detect IL-5, IL-13, IL-16, IL-33, I-309/CCL1, TARC/CCL17, monocyte-derived chemokine/CCL22, periostin, and eosinophil cationic protein levels in nasal lavages from patients with AERD and patients with ARwA...
December 13, 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27940218/multiplex-assay-reliability-and-long-term-intra-individual-variation-of-serologic-inflammatory-biomarkers
#17
Heather S McKay, Joseph B Margolick, Otoniel Martínez-Maza, Joseph Lopez, John Phair, Giovanna Rappocciolo, Thomas N Denny, Larry I Magpantay, Lisa P Jacobson, Jay H Bream
BACKGROUND: Circulating cytokines, chemokines, and soluble cytokine receptors can serve as biomarkers of inflammation and immune dysregulation. Good reliability of multiplex platforms, which allow for simultaneous, comprehensive biomarker assessment, is critical for their utility in epidemiologic studies. We examined the reliability of the Meso-Scale Discovery (MSD) platform to simultaneously quantitate 15 cytokines and chemokines and the Luminex platform (R&D Systems) to quantitate 5 soluble receptors and 2 chemokines and cytokines and evaluated long-term within-person correlation of these biomarkers...
December 8, 2016: Cytokine
https://www.readbyqxmd.com/read/27897453/clinical-usefulness-of-simultaneous-measurement-of-the-tear-levels-of-ccl17-ccl24-and-il-16-for-the-biomarkers-of-allergic-conjunctival-disorders
#18
Jun Shoji, Hiroshi Aso, Noriko Inada
PURPOSE: This study investigated the clinical usefulness of a multiple tear cytokine/chemokine test by simultaneously determining tear levels of CC chemokine ligand 17 (CCL17)/thymus and activation-regulated chemokine (TARC), CCL24/eotaxin-2, and interleukin-16 (IL-16) for assessing acute and chronic allergic inflammation in allergic conjunctival disorders (ACDs). SUBJECTS AND METHODS: This study included 37 patients with ACD and 11 healthy adults (controls). Patients with ACDs were divided into the following three groups; patients with allergic conjunctivitis (AC group, n = 17), patients with atopic keratoconjunctivitis (AKC group, n = 6), and patients with vernal keratoconjunctivitis (VKC group, n = 14)...
November 29, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27897229/global-gene-regulation-during-activation-of-immunoglobulin-class-switching-in-human-b-cells
#19
Youming Zhang, David J Fear, Saffron A G Willis-Owen, William O Cookson, Miriam F Moffatt
Immunoglobulin class switch recombination (CSR) to IgE is a tightly regulated process central to atopic disease. To profile the B-cell transcriptional responses underlying the activation of the germinal centre activities leading to the generation of IgE, naïve human B-cells were stimulated with IL-4 and anti-CD40. Gene expression and alternative splicing were profiled over 12 days using the Affymetrix Human Exon 1.0 ST Array. A total of 1,399 genes, forming 13 temporal profiles were differentially expressed...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27893098/vitreal-cytokine-profile-differences-between-eyes-with-epiretinal-membranes-or-macular-holes
#20
Souska Zandi, Christoph Tappeiner, Isabel B Pfister, Alain Despont, Robert Rieben, Justus G Garweg
Purpose: Cytokines play an important role in cell signaling in inflammatory and repair processes, also within the posterior segment of the eye. These molecules are thus implicated in the pathophysiology of several vitreoretinal diseases. In the present study, we compared vitreal cytokine profiles in patients with idiopathic epiretinal membranes (ERMs) and idiopathic full-thickness macular holes (MHs) without epiretinal membranes. Methods: Native vitreal humor was collected during elective pars plana vitrectomy for the treatment of macular pathologies (group 1: ERM; group 2: MH) from patients without any other ocular or systemic disease...
November 1, 2016: Investigative Ophthalmology & Visual Science
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