Yufang Rao, Ke Qiu, Yao Song, Minzi Mao, Lan Feng, Danni Cheng, Junhong Li, Ziyan Zhang, Yuyang Zhang, Xiuli Shao, Wendu Pang, Yan Wang, Xuemei Chen, Chuanhuan Jiang, Sisi Wu, Shuaishuai Yu, Jun Liu, Haiyang Wang, Xingchen Peng, Lin Yang, Li Chen, Xiaosong Mu, Yongbo Zheng, Wei Xu, Geoffrey Liu, Fei Chen, Haopeng Yu, Yu Zhao, Jianjun Ren
Exhausted CD8+ T cells (Texs) are characterized by the expression of various inhibitory receptors (IRs), whereas the functional attributes of these co-expressed IRs remain limited. Here, we systematically characterized the diversity of IR co-expression patterns in Texs from both human oropharyngeal squamous cell carcinoma (OPSCC) tissues and syngeneic OPSCC model. Nearly 60% of the Texs population co-expressed two or more IRs, and the number of co-expressed IRs was positively associated with superior exhaustion and cytotoxicity phenotypes...
May 17, 2024: IScience