keyword
https://read.qxmd.com/read/38527610/prevalence-of-apical-periodontitis-in-patients-with-autoimmune-liver-diseases-under-immune-suppressants-and-immune-modulators-a-cross-sectional-study
#1
JOURNAL ARTICLE
Francesca Ideo, Sadia Niazi, Luchino Chessa, Michela Miglianti, Giulia Bardini, Francesco Mannocci, Elisabetta CottiDDS
INTRODUCTION: Autoimmune liver diseases (ALDs) are chronic conditions generated by an immune-mediated auto-aggressive inflammatory reaction in genetically susceptible individuals. The purpose of this study was to evaluate the prevalence of AP in patients suffering from ALDs, in treatment with the immune-suppressants glucocorticoids, azathioprine, and/or ursodeoxycholic acid. METHODS: The ALDs group included 46 patients (11 men and 35 women, average age: 57.9 ± 11...
March 23, 2024: Journal of Endodontics
https://read.qxmd.com/read/38504287/characterisation-and-evaluation-of-physical-properties-of-ah-plus-sealer-with-and-without-the-incorporation-of-petasin-pachymic-acid-curcumin-and-shilajit-an-invitro-study
#2
JOURNAL ARTICLE
Selvanathan Mj Vinola, Sekar Mahalaxmi
BACKGROUND: AH Plus, an epoxy resin-based sealer, is widely used in endodontic practice, owing to its good physical properties that confers longstanding dimensional stability and good adhesion to dentin. Nevertheless, its propensity to trigger inflammation, especially in its freshly mixed state, has been extensively documented. Phytochemicals such as Petasin, Pachymic acid, Curcumin, and Shilajit are known for their anti-inflammatory and analgesic effects. This study aimed to analyze and determine the effect of these natural products on the physical properties of AH Plus sealer when incorporated with the sealer...
March 19, 2024: BMC Oral Health
https://read.qxmd.com/read/38491076/effect-of-sodium-hypochlorite-ethylenediaminetetraacetic-acid-and-dual-rinse-irrigation-on-dentin-adhesion-using-an-etch-and-rinse-or-self-etch-approach
#3
JOURNAL ARTICLE
Matej Par, Tobias Steffen, Selinay Dogan, Noah Walser, Tobias T Tauböck
The aim was to investigate the influence of endodontic irrigation solutions and protocols on the micro-tensile bond strength (μTBS) to dentin using an etch-and-rinse (ER) or self-etch (SE) adhesive approach. Eighty extracted human molars were ground to dentin. After pretreating for 27 min (21 min-3 min-3 min) with five different endodontic irrigation protocols (Group 1: NaOCl-EDTA-NaOCl; Group 2: NaOCl-NaOCl-EDTA; Group 3: NaOCl-NaCl-NaOCl; Group 4: Dual Rinse-Dual Rinse-Dual Rinse; Group 5: NaCl-NaCl-NaCl), an ER (Optibond FL, Kerr) or a SE (Clearfil SE Bond, Kuraray) adhesive system was applied...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38463481/effect-of-collagen-cross-linking-agents-on-the-depth-of-penetration-of-bioceramic-sealer-and-release-of-hydroxyproline-an-in-vitro-study
#4
JOURNAL ARTICLE
K Hanisha Reddy, Bollineni Swetha, B Devi Priya, T Murali Mohan, Duvvuri Lakshmi Malini, M Sai Sravya
CONTEXT: During endodontic treatment, sealers seal off dentinal tubules and prevent microbial attack. Bioceramic sealers have excellent bioactivity, but its high alkalinity is found to have detrimental effects on radicular collagen. Collagen cross linkers have the ability to chemically modify collagen and can prevent the detrimental effects of the sealer. AIM: This research was aimed to assess the effect of collagen cross-linking agents on the integrity of radicular collagen matrix and depth of penetration of sealer...
February 2024: J Conserv Dent Endod
https://read.qxmd.com/read/38463473/an-in-vitro-comparison-of-calcium-ions-release-and-diffusion-ability-of-calcium-hydroxide-based-intracanal-medicament-in-combination-with-three-different-vehicles-like-propolis-chitosan-and-propylene-glycol
#5
JOURNAL ARTICLE
Pinku T Thomas, Jyoti Sumi Issac, Parvathy Girija, Lekshmi S Chandran, D S Arjun, A J Siddik
CONTEXT: Calcium hydroxide, which is an intracanal medicament, is widely used in endodontics. Improvements can be made to its effectiveness, as calcium hydroxide is dependent on the vehicle. AIM: The study aims to compare and evaluate the release and diffusion ability of calcium hydroxide when mixed with - propolis, chitosan, and propylene glycol. METHODS: For this study, 33 single-rooted extracted premolar teeth have been decoronated. After the working length and enlargement of the canals had been established, different preparations of calcium hydroxide with vehicles such as propolis, chitosan, and propylene glycol were loaded into the canals...
February 2024: J Conserv Dent Endod
https://read.qxmd.com/read/38457086/influence-of-systemic-antibiotic-therapy-on-the-development-and-progression-of-induced-apical-periodontitis-in-wistar-rats
#6
JOURNAL ARTICLE
Flávio Duarte Faria, Cristiane Cantiga-Silva, Carolina de Barros Morais Cardoso, Nathália Evelyn da Silva Machado, Pedro Henrique Chaves de Oliveira, Mariana Pagliusi Justo, Juliana Goto, Rogério de Castilho Jacinto, Gustavo Sivieri-Araújo, Luciano Tavares Angelo Cintra
The aim of this study was to investigate the influence of systemic antibiotic therapy on the development and progression of induced apical periodontitis (AP) in Wistar rats. Fifty-six rats were submitted to pulp exposure of the lower left first molar for the induction of AP. On the same day, intraperitoneal antibiotic therapy was administered once a day, for 15 days, until euthanasia. The groups were formed according to the different treatments (n = 8): C-control; GEN-treated with gentamicin (10 mg/Kg); AC-treated with amoxicillin (100 mg/Kg); MZ-treated with metronidazole (40 mg/Kg); AMP-treated with ampicillin (100 mg/Kg); AMC group-treated with amoxicillin + clavulanic acid (100 mg/kg); CLI-treated with clindamycin (60 mg/kg)...
March 8, 2024: Odontology
https://read.qxmd.com/read/38449492/prevalence-of-salivary-microbial-load-and-lactic-acid-presence-in-diabetic-and-non-diabetic-individuals-with-different-dental-caries-stages
#7
JOURNAL ARTICLE
Monika Mohanty, Shashirekha Govind, Shakti Rath
OBJECTIVES: This study aims to correlate caries-causing microorganism load, lactic acid estimation, and blood groups to high caries risk in diabetic and non-diabetic individuals and low caries risk in healthy individuals. MATERIALS AND METHODS: This study includes 30 participants divided into 3 groups: Group A, High-risk caries diabetic individuals; Group B, High-risk caries non-diabetic individuals; and Group C, Low-risk caries individuals. The medical condition, oral hygiene, and caries risk assessment (American Dental Association classification and International Caries Detection and Assessment System scoring) were documented...
February 2024: Restorative Dentistry & Endodontics
https://read.qxmd.com/read/38447912/the-evaluation-of-anti-osteoclastic-activity-of-the-novel-calcium-hydroxide-biodegradable-nanoparticles-as-an-intracanal-medicament
#8
JOURNAL ARTICLE
Patarawadee Promta, Patcharaporn Chaiyosang, Aussara Panya, Pongrapee Laorodphun, Warat Leelapornpisid, Napatsorn Imerb
INTRODUCTION: The aim of this study was to evaluate the anti-osteoclastic activity of calcium hydroxide-loaded poly(lactic-co-glycolic acid) nanoparticles (Ca(OH)2 -loaded PLGA NPs) in comparison to calcium hydroxide nanoparticles (Ca(OH)2 NPs). METHODS: RAW 264.7 cell lines (third-fifth passage) were cultured and incubated with soluble receptor activator of nuclear factor-κB ligand (RANKL) in triplicates. Subsequently, Ca(OH)2 -loaded PLGA NPs and Ca(OH)2 NPs were added for 7 days to evaluate their effects on RANKL-induced osteoclast differentiation of RAW 264...
March 4, 2024: Journal of Endodontics
https://read.qxmd.com/read/38441321/harnessing-antimicrobial-peptides-in-endodontics
#9
REVIEW
Xinzi Kong, Vijetha Vishwanath, Prasanna Neelakantan, Zhou Ye
Endodontic therapy includes various procedures such as vital pulp therapy, root canal treatment and retreatment, surgical endodontic treatment and regenerative endodontic procedures. Disinfection and tissue repair are crucial for the success of these therapies, necessitating the development of therapeutics that can effectively target microbiota, eliminate biofilms, modulate inflammation and promote tissue repair. However, no current endodontic agents can achieve these goals. Antimicrobial peptides (AMPs), which are sequences of amino acids, have gained attention due to their unique advantages, including reduced susceptibility to drug resistance, broad-spectrum antibacterial properties and the ability to modulate the immune response of the organism effectively...
March 5, 2024: International Endodontic Journal
https://read.qxmd.com/read/38425325/comparison-of-the-accuracy-of-apex-locator-digital-radiography-and-cone-beam-computed-tomography-in-root-canal-working-length-determination-in-teeth-with-external-root-resorption-an-in-vitro-study
#10
JOURNAL ARTICLE
Seyed Mohsen Hasheminia, Sanaz Jahadi, Farida Ghazanfari Moghaddam, Shervin Bagherieh
BACKGROUND: The aim of this study was to compare the accuracy of apex locator, digital periapical radiography, and cone-beam computed tomography (CBCT) for determining the root canal working length (WL) in teeth with external root resorption (ERR). MATERIALS AND METHODS: In this in vitro study, the sample consisted of 54 extracted permanent single-rooted human teeth. ERRs were performed at the 3 mm apical root using 65% of nitric acid for 24 h. After determining the actual WL by K-file #10 (gold standard) with the visualization method, the teeth were mounted in alginate and the WL of each tooth was determined using the electronic apex locator (EAL) equipped with a K-file #15...
2024: Dental Research Journal
https://read.qxmd.com/read/38376094/investigation-of-the-early-apical-release-from-endodontic-hydrogels-a-3d-printed-model
#11
JOURNAL ARTICLE
Marianne Leveque, Mourad Bekhouche, Jean-Christophe Farges, Raphaël Richert, Maxime Ducret
AIM: Regenerative Endodontic Procedures (REPs) using new materials such as hydrogels aim to replace current endodontic treatments, but numerous limitations are to overcome. Apical release was little explored in previous studies, especially regarding hydrogels that incorporate molecules, such as growth factors and antibiotics. Apical release is a key mechanism in achieving regeneration, as it could regulate disinfection or cell colonization. Few models exist for apical release, limiting the transfer of these devices from bench to bedside...
February 20, 2024: International Endodontic Journal
https://read.qxmd.com/read/38374518/calcium-hydroxide-loaded-nanoparticles-dispersed-in-thermosensitive-gel-as-a-novel-intracanal-medicament
#12
JOURNAL ARTICLE
Xavier Roig, Lyda Halbaut, Firas Elmsmari, Rubén Pareja, Aizea Arrien, Fernando Duran-Sindreu, Luis María Delgado, Marta Espina, María Luisa García, José Antonio González Sánchez, Elena Sánchez-López
AIM: Design, produce and assess the viability of a novel nanotechnological antibacterial thermo-sensible intracanal medicament This involves encapsulating calcium hydroxide (Ca(OH)2 ) within polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) and dispersing them in a thermosensitive gel (Ca(OH)2 -NPs-gel). In addition, perform in vitro and ex vivo assessments to evaluate tissue irritation and penetration capacity into dentinal tubules in comparison to free Ca(OH)2 . METHODOLOGY: Reproducibility of Ca(OH)₂-NPs was confirmed by obtaining the average size of the NPs, their polydispersity index, zeta potential and entrapment efficiency...
February 19, 2024: International Endodontic Journal
https://read.qxmd.com/read/38340038/next-generation-antibacterial-nanopolymers-for-treating-oral-chronic-inflammatory-diseases-of-bacterial-origin
#13
REVIEW
Manuel Toledano-Osorio, Raquel Osorio, Jaime Bueno, Cristina Vallecillo, Marta Vallecillo-Rivas, Mariano Sanz
BACKGROUND: 'Periodontitis' refers to periodontal destruction of connective tissue attachment and bone, in response to microorganisms forming subgingival biofilms on the root surface, while 'apical periodontitis' refers to periapical inflammatory processes occurring in response to microorganisms within the root canal system. The treatment of both diseases is based on the elimination of the bacterial challenge, though its predictability depends on the ability of disrupting these biofilms, what may need adjunctive antibacterial strategies, such as the next-generation antibacterial strategies (NGAS)...
February 10, 2024: International Endodontic Journal
https://read.qxmd.com/read/38323923/final-irrigation-with-bioglass-solution-in-regenerative-endodontic-procedure-induces-tissue-formation-inside-the-root-canals-collagen-maturation-proliferation-cell-and-presence-of-osteocalcin
#14
JOURNAL ARTICLE
Kiani Dos Santos de Paula, Alexandre Henrique Dos Reis-Prado, Witalo Pereira de Jesus, Juliana Goto, Lara Cancella de Arantes, Marina Verçosa, Luciano Tavares Angelo Cintra, Edilson Ervolino, Raphael Escorsim Szawka, Murilo Camuri Crovace, Ricardo Alves de Mesquita, Francine Benetti
AIM: To evaluate the influence of an experimental solution of cobalt-doped F18 bioactive glass (F18Co) on tissue repair following regenerative endodontic procedure (REP) in rat molars. METHODOLOGY: The F18Co solution was prepared at a ratio of 1:5 F18Co powder to distilled water. The right or left upper first molars of 12 Wistar rats were used, where the pulps were exposed, removed, and irrigated with 2.5% sodium hypochlorite (NaOCl), followed by 17% ethylenediaminetetraacetic acid (EDTA) (5 min each)...
February 7, 2024: International Endodontic Journal
https://read.qxmd.com/read/38317393/effect-of-boswellic-acid-on-viability-of-dental-pulp-stem-cells-compared-to-the-commonly-used-intracanal-medications-an-in-vitro-study
#15
JOURNAL ARTICLE
Nouran Ahmad Amer, Manal Farouk Badawi, Mohamed Gamal Elbeltagi, Amany Elsaid Badr
AIM: This study was aimed at evaluating the effect of acetyl-11-keto-β-boswellic acid (AKBA) on dental pulp stem cells (DPSCs) viability and proliferation to be used as a potential root canal medicament. MATERIALS AND METHODS: Dental pulp stem cells were isolated from human third molars. The phenotypic characterization of DPSCs was verified by flow cytometry analysis. The viability assay was performed using the methyl-thiazoltetrazolium (MTT) assay. Cells were treated with different concentration of triple antibiotic paste (TAP) and calcium hydroxide Ca(OH2 ) (5, 2...
December 1, 2023: Journal of Contemporary Dental Practice
https://read.qxmd.com/read/38303880/in%C3%A2-vitro-cytotoxicity-and-antibacterial-activity-of-hypochlorous-acid-antimicrobial-agent
#16
JOURNAL ARTICLE
Cheng-Feng Tsai, Jia-Jia Chung, Shinn-Jyh Ding, Chun-Cheng Chen
BACKGROUND/PURPOSE: Bacteria-associated oral diseases such as dental caries and periodontitis are widespread epidemics that cause oral pain and loss of function. The purpose of this study was to evaluate the in vitro cytotoxicity and antibacterial activity of different concentrations of hypochlorous acid (HOCl). MATERIALS AND METHODS: Five different concentrations (100, 200, 300, 400, and 500 ppm) of HOCl were evaluated for their antimicrobial efficacy against Gram-negative ( A...
January 2024: Journal of Dental Sciences
https://read.qxmd.com/read/38219035/the-effect-of-hydrogel-hyaluronic-acid-on-dentine-sialophosphoprotein-expression-of-human-dental-pulp-stem-cells
#17
JOURNAL ARTICLE
Valonia Irene Nugraheni, Dini Asrianti Bagio, Anggraini Margono, Indah Julianto
OBJECTIVE: Hyaluronic acid (HA) is glycosaminoglycan and one of important factors in extracellular matrix. In an inflamed pulp, when niche biology is conducive, the recruitment of human dental pulp stem cells (hDPSCs) will take place and differentiate into odontoblast like cell, creating reparative dentine and expressing dentine sialophosphoprotein (DSPP). Therefore, the purpose of this study was to analyze the potential of hydrogel HA in various concentration towards hDPSCs differentiation via DSPP expression at day 7 and 14...
August 2023: European Endodontic Journal
https://read.qxmd.com/read/38219034/evaluation-of-effect-of-natural-extract-sodium-gluconate-on-smear-layer-and-dentine-decalcification-compared-with-edta-an-in-vitro-study
#18
JOURNAL ARTICLE
Hari Raghavendar Karthikeyan, Arasappan Rajakumaran, Mathan Rajan Rajendran, Lakshmi Balaji
OBJECTIVE: Mechanical instrumentation of the root canal system generates a smear layer on the canal walls which are removed most commonly with the help of chelators such as ethylenediaminetetraacetic acid (EDTA) but can potentially cause severe dentinal erosion. Considerable research has been conducted to find an al- ternative to EDTA which removes the smear layer without causing dentinal erosion. The current study aimed at evaluating the ability of sodium gluconate compared with that of 17% EDTA in smear layer removal along with its effect on dentine decalcification when used as a final irrigant...
August 2023: European Endodontic Journal
https://read.qxmd.com/read/38219031/effectiveness-of-triton-irrigation-solution-in-smear-layer-removal-an-in-vitro-study
#19
JOURNAL ARTICLE
Huda Wakas Oraim, Iman Mohammed Al-Zaka
OBJECTIVE: This in vitro study aimed to compare and evaluate the effectiveness of different irrigation solutions, including Triton, 0.5% Chitosan nanoparticles (CNP), and 17% ethylenediaminetetraacetic acid (EDTA), on the smear layer removal of the root canal walls. METHODS: Forty extracted sound mandibular premolars were examined; the samples were decoronated to obtain a root length of 14 mm. Each sample was instrumented using ProTaper Next rotary file X4 (40/0...
January 12, 2024: European Endodontic Journal
https://read.qxmd.com/read/38185301/applications-of-selected-polysaccharides-and-proteins-in-dentistry-a-review
#20
REVIEW
Abdullah Alsalhi
In the last ten years, remarkable characteristics and a variety of functionalities have been created in biopolymeric materials for clinical dental applications. This review gives an overview of current knowledge of natural biopolymers (biological macromolecules) in terms of structural, functional, and property interactions. Natural biopolymers such as polysaccharides (chitosan, bacterial cellulose, hyaluronic acid, and alginate) and polypeptides (collagen and silk fibroin) have been discussed for dental uses...
January 5, 2024: International Journal of Biological Macromolecules
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