Xavier Roig, Lyda Halbaut, Firas Elmsmari, Rubén Pareja, Aizea Arrien, Fernando Duran-Sindreu, Luis María Delgado, Marta Espina, María Luisa García, José Antonio González Sánchez, Elena Sánchez-López
AIM: Design, produce and assess the viability of a novel nanotechnological antibacterial thermo-sensible intracanal medicament This involves encapsulating calcium hydroxide (Ca(OH)2 ) within polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) and dispersing them in a thermosensitive gel (Ca(OH)2 -NPs-gel). In addition, perform in vitro and ex vivo assessments to evaluate tissue irritation and penetration capacity into dentinal tubules in comparison to free Ca(OH)2 . METHODOLOGY: Reproducibility of Ca(OH)₂-NPs was confirmed by obtaining the average size of the NPs, their polydispersity index, zeta potential and entrapment efficiency...
February 19, 2024: International Endodontic Journal