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https://www.readbyqxmd.com/read/28079309/bioactive-injectable-aggregates-with-nanofibrous-microspheres-and-human-dental-pulp-stem-cells-a-translational-strategy-in-dental-endodontics
#1
I Garzón, M A Martin-Piedra, V Carriel, M Alaminos, X Liu, R D Souza
Regeneration of the pulp-dentin complex with stem cells is a potential alternative to conventional root canal treatments. Human dental pulp stem cells (hDPSCs) have been extensively studied because of their ability to proliferate and differentiate into mineralized dental and nondental tissues. In this work we combined hDPSCs with two types of injectable poly-L-lactic acid (PLLA) microspheres with a nanofibrous or smooth surface to form bioactive injectable aggregates, and examined their ability to promote pulp regeneration in the root canal in an in vivo model...
January 12, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28041686/evaluation-of-a-commercially-available-hyaluronic-acid-hydrogel-restylane-as-injectable-scaffold-for-dental-pulp-regeneration-an-in%C3%A2-vitro-evaluation
#2
Vanessa Chrepa, Obadah Austah, Anibal Diogenes
INTRODUCTION: Regenerative endodontic procedures (REPs) are viable alternatives for treating immature teeth, yet these procedures do not predictably lead to pulp-dentin regeneration. A true bioengineering approach for dental pulp regeneration requires the incorporation of a scaffold conducive with the regeneration of the pulp-dentin complex. Several materials have been proposed as scaffolds for REPs; nonetheless, the majority are not eligible for immediate clinical chairside use. Thus, the aim of this study was to evaluate Restylane, a Food and Drug Administration-approved hyaluronic acid-based gel, as possible scaffold for REPs...
December 29, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/28038357/streptococcus-gordonii-induces-nitric-oxide-production-through-its-lipoproteins-stimulating-toll-like-receptor-2-in-murine-macrophages
#3
Hyun Young Kim, Jung Eun Baik, Ki Bum Ahn, Ho Seong Seo, Cheol-Heui Yun, Seung Hyun Han
Streptococcus gordonii, a Gram-positive commensal in the oral cavity, is an opportunistic pathogen that can cause endodontic and systemic infections resulting in infective endocarditis. Lipoteichoic acid (LTA) and lipoprotein are major virulence factors of Gram-positive bacteria that are preferentially recognized by Toll-like receptor 2 (TLR2) on immune cells. In the present study, we investigated the effect of S. gordonii LTA and lipoprotein on the production of the representative inflammatory mediator nitric oxide (NO) by the mouse macrophages...
December 27, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/28005295/antibiotics-in-endodontics-a-review
#4
REVIEW
J J Segura-Egea, K Gould, B Hakan Şen, P Jonasson, E Cotti, A Mazzoni, H Sunay, L Tjäderhane, P M H Dummer
The overuse of antibiotics and the emergence of antibiotic-resistant bacterial strains is a global concern. This concern is also of importance in terms of the oral microbiota and the use of antibiotics to deal with oral and dental infections. The aim of this paper is to review the current literature on the indications and use of antibiotics and to make recommendations for their prescription in endodontic patients. Odontogenic infections, including endodontic infections, are polymicrobial, and in most cases, the prescription of antibiotics is empirical...
December 22, 2016: International Endodontic Journal
https://www.readbyqxmd.com/read/28001242/effect-of-the-time-point-of-acid-etching-on-the-persistence-of-sealer-residues-after-using-different-dental-cleaning-protocols
#5
Keren Cristina Fagundes Jordão-Basso, Milton Carlos Kuga, Matheus Coêlho Bandéca, Marco Antonio Hungaro Duarte, Flávia Angélica Guiotti
Endodontic sealer residues remaining within the pulp chamber dentin after root canal obturation and cleaning with various solvents may compromise the appearance and the durability of dental restorations. Acid etching is routinely performed prior to application of dentine adhesive systems, but is effect on residual sealer material and the optimal time-point for performing etching, are unknown. Here, we evaluated the effect of acid etching on the dentin surface when performed either immediately or 7 days after removal of the endodontic sealer with two solvents, i...
December 22, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/28000644/comparative-analysis-of-cleaning-ability-of-three-nickel-titanium-rotary-systems-protaper-universal-k3-and-mtwo-an-in-vitro-scanning-electron-microscopic-study
#6
Ambar W Raut, Vijay Mantri, Aparna Palekar, Rupal Gadodia, Shubham Kala, Radha A Raut
BACKGROUND: Endodontic instruments including the nickel-titanium (NiTi) instruments produce debris and smear layer during instrumentation. The study was carried out to evaluate and compare the cleaning effectiveness of root canal preparation using three different rotary NiTi instrumentation systems - ProTaper Universal, K3 and Mtwo by means of scanning electron microscopy (SEM). METHODS: Thirty-six freshly extracted permanent mandibular molars were randomly divided into four groups: ProTaper Universal, K3, Mtwo system and control group...
October 2016: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27994888/a-rare-malignant-peripheral-nerve-sheath-tumor-of-the-maxilla-mimicking-a-periapical-lesion
#7
José Alcides Arruda, Pamella Álvares, Luciano Silva, Alexandrino Pereira Dos Santos Neto, Cleomar Donizeth Rodrigues, Antônio Caubi, Marcia Silveira, Sandra Sayão, Ana Paula Sobral
Malignant peripheral nerve sheath tumor is a malignant neoplasm that is rarely found in the oral cavity. About 50% of this tumor occurs in patients with neurofibromatosis type I and comprises approximately 10% of all soft tissue sarcomas of head and neck region. Intraosseous malignant peripheral nerve sheath tumor of the maxilla is rare. This article is the first to address malignant peripheral nerve sheath tumor of the maxilla presenting as a periapical radiolucency on nonvital endodontically treated teeth in the English medical literature...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27982236/limewater-and-polymyxin-b-associated-with-naocl-for-endotoxin-detoxification-in-root-canal-with-necrotic-pulp
#8
Alessandra Sverberi Carvalho, Luciane Dias de Oliveira, Flávia Goulart da Rosa Cardoso, Felipe Eduardo de Oliveira, Marcia Carneiro Valera, Cláudio Antônio Talge Carvalho
This clinical study investigated the effects of endodontic treatment by using different irrigants (limewater + NaOCl and polymyxin B + NaOCl) and intracanal medication on endotoxins in teeth with primary endodontic infection and radiographically visible apical periodontitis. Thirty-three teeth with necrotic pulp and periapical lesions from different patients were selected for this study. Samples were collected after the coronal opening (S1) and after instrumentation (S2). Root canals were divided in 3 groups (n = 11) according to the irrigant combination used: NaOCl + LW: 2...
September 2016: Brazilian Dental Journal
https://www.readbyqxmd.com/read/27892627/withdrawn-pulp-management-for-caries-in-adults-maintaining-pulp-vitality
#9
REVIEW
Hiroshi Miyashita, Helen V Worthington, Alison Qualtrough, Alphons Plasschaert
BACKGROUND: There is a range of treatment options for the management of the pulp in extensively decayed teeth. These include direct and indirect pulp capping, pulpotomy or pulpectomy. If the tooth is symptomatic or if there are periapical bone changes, then endodontic treatment is required. However, if the tooth is asymptomatic but the caries is extensive, there is no consensus as to the best method of management. In addition, there has been a recent move towards using alternative materials and methods such as the direct or indirect placement of bonding agents and mineral trioxide aggregate...
28, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27794157/assessment-of-the-incidence-of-posttreatment-endodontic-flare-ups-in-patients-undergoing-single-sitting-root-canal-therapies-a-clinical-study
#10
Harsh Priyank, T M Chaitra Devi, Pallavi Goel, Nivedita Sahu, Shweta Nihalani, Ashutosh Shandilya
INTRODUCTION: Endodontic therapy is one of the commonly used procedures for treating the teeth affected by various pathologies. One of the major problems for endodontists despite the advancements in the root canal procedures is the posttreatment endodontic flare-ups. Much debate exists regarding the completion of endodontic therapy in a single sitting or multiple sittings. Hence, we assessed the incidence of endodontic flare-ups in patients undergoing single-sitting root canal therapies...
October 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27790583/comparative-assessment-of-antimicrobial-efficacy-of-different-antibiotic-coated-gutta-percha-cones-on-enterococcus-faecalis-an-invitro-study
#11
Vardhaman Mulchand Jain, Gundabaktha Nagappa Karibasappa, Arun Suresh Dodamani, Prashanth Kumar Vishwakarma, Gaurao Vasant Mali
INTRODUCTION: The major goal of endodontic treatment is to eliminate bacteria from the root canals and prevent re-infection. Enterococcus faecalis (E. faecalis) has been attributed to be the most common organism for the endodontic treatment failures. The choice of endodontic material that have high antimicrobial efficacy can help in decreasing/avoiding growth of micro-organisms and facilitate the success rate of treatment. AIM: The present study was designed with an aim to evaluate the antimicrobial efficacy of antibiotic coated gutta-percha cones on E...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27766106/the-effect-of-different-cleaning-protocols-on-post-space-a-sem-study
#12
Giuseppe Lo Giudice, Angelo Lizio, Roberto Lo Giudice, Antonio Centofanti, Giuseppina Rizzo, Michele Runci, Angela Alibrandi, Marco Cicciù
Aim. Purpose of the present paper is to analyze the efficiency of different post-space irrigation protocols. Methods. 28 single rooted teeth were endodontically treated. After post-space preparation every sample was assigned to one of three experimental groups and to one control group. In each group different irrigation protocols were performed as follows: EDTA (Group A), 37% orthophosphoric acid (Group B), and EDTA + 37% orthophosphoric acid with ultrasounds activation (Group C). In the control group (Group D) the irrigate association was not activated by ultrasounds...
2016: International Journal of Dentistry
https://www.readbyqxmd.com/read/27759881/endodontic-procedures-for-retreatment-of-periapical-lesions
#13
REVIEW
Massimo Del Fabbro, Stefano Corbella, Patrick Sequeira-Byron, Igor Tsesis, Eyal Rosen, Alessandra Lolato, Silvio Taschieri
BACKGROUND: When primary root canal therapy fails, periapical lesions can be retreated with or without surgery. Root canal retreatment is a non-surgical procedure that involves removal of root canal filling materials from the tooth, followed by cleaning, shaping and obturating of the canals. Root-end resection is a surgical procedure that involves exposure of the periapical lesion through an osteotomy, surgical removal of the lesion, removal of part of the root-end tip, disinfection and, commonly, retrograde sealing or filling of the apical portion of the remaining root canal...
October 19, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27742205/resistance-profiles-to-antimicrobial-agents-in-bacteria-isolated-from-acute-endodontic-infections-systematic-review-and-meta-analysis
#14
REVIEW
Pauline M Lang, Rogério C Jacinto, Tatiane S Dal Pizzol, Maria Beatriz C Ferreira, Francisco Montagner
Infected root canal or acute apical abscess exudates can harbour several species, including Fusobacterium, Porphyromonas, Prevotella, Parvimonas, Streptococcus, Treponema, Olsenella and not-yet cultivable species. A systematic review and meta-analysis was performed to assess resistance rates to antimicrobial agents in clinical studies that isolated bacteria from acute endodontic infections. Electronic databases and the grey literature were searched up to May 2015. Clinical studies in humans evaluating the antimicrobial resistance of primary acute endodontic infection isolates were included...
November 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27706660/preliminary-study-on-total-protein-extraction-methods-from-enterococcus-faecalis-biofilm
#15
W Chen, J Liang, Z He, W Jiang
Enterococcus faecalis is the major pathogen of post-endodontic disease and refractory periapical periodontitis, and recent research on this species has focused on its pathogenicity. E. faecalis most often causes disease in the form of a biofilm, and total protein expression shows a strong association with its virulence. Therefore, the purpose of our study was to explore different methods of extracting the total proteins of the E. faecalis (ATCC 33186 standard strain) biofilm. The total proteins in the biofilm were extracted using an ultrasonication method with varied parameters, including duration, amplitude setting, period, and duty cycle...
August 30, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27652250/comparative-analysis-of-endodontic-smear-layer-removal-efficacy-of-17-ethylenediaminetetraacetic-acid-7-maleic-acid-and-2-chlorhexidine-using-scanning-electron-microscope-an-in-vitro-study
#16
Kailash Attur, Mathew T Joy, Riyas Karim, V J Anil Kumar, C Deepika, Haseena Ahmed
AIM: The aim of the present study was to evaluate the efficiency of different endodontic irrigants in the removal of smear layer through scanning electron microscopic image analysis. MATERIALS AND METHODS: The present in vitro study was carried out on 45 single-rooted extracted human mandibular premolar teeth with single canal and complete root formation. Teeth were randomly assigned to three groups with 15 teeth in each group. Group I samples were irrigated with 17% ethylenediaminetetraacetic (EDTA) irrigation, Group II with 7% maleic acid irrigation, and Group III with 2% chlorhexidine irrigation...
August 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/27595725/comparative-evaluation-of-smear-layer-and-debris-on-the-canal-walls-prepared-with-a-combination-of-hand-and-rotary-protaper-technique-using-scanning-electron-microscope
#17
S Kiran, Sandeep Prakash, Pujari R Siddharth, Supradip Saha, Naiza E Geojan, Mookambika Ramachandran
INTRODUCTION: The effect of smear layer and debris on the success rate of endodontic treatment has not yet been definitely determined. So the present study was aimed to evaluate the amount of smear layer and debris on the canal walls prepared with a combination of hand and rotary ProTaper technique using NaOCl and ethylenediaminetetraacetic acid (EDTA) alternately as root canal irrigants using scanning electron microscope (SEM). MATERIALS AND METHODS: Eighty intact freshly extracted human permanent mandibular premolar teeth were collected and randomly divided equally into four groups...
July 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27555893/effect-of-dimethyl-sulfoxide-on-bond-durability-of-fiber-posts-cemented-with-etch-and-rinse-adhesives
#18
Fereshteh Shafiei, Mahtab Memarpour, Zahra Sarafraz
PURPOSE: This study was undertaken to investigate whether use of an adhesive penetration enhancer, dimethyl sulfoxide (DMSO), improves bond stability of fiber posts to root dentin using two two-step etch-and-rinse resin cements. MATERIALS AND METHODS: Forty human maxillary central incisor roots were randomly divided into 4 groups after endodontic treatment and post space preparation, based on the fiber post/cement used with and without DMSO pretreatment. Acid-etched root dentin was treated with 5% DMSO aqueous solution for 60 seconds or with distilled water (control) prior to the application of Excite DSC/Variolink II or One-Step Plus/Duo-link for post cementation...
August 2016: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/27520407/sodium-hypochlorite-inactivates-lipoteichoic-acid-of-enterococcus-faecalis-by-deacylation
#19
Sun Woong Hong, Jung Eun Baik, Seok-Seong Kang, Kee-Yeon Kum, Cheol-Heui Yun, Seung Hyun Han
INTRODUCTION: Enterococcus faecalis is a pathogenic gram-positive bacterium closely associated with apical periodontitis. Although sodium hypochlorite (NaOCl) has been used as a common endodontic irrigant to eradicate bacteria in the root canal, it has not been elucidated whether NaOCl attenuates the inflammatory response induced by the E. faecalis virulence factor lipoteichoic acid (EfLTA). METHODS: Structurally intact EfLTA purified from E. faecalis was treated with NaOCl at various concentrations and time periods...
October 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27307670/comparison-of-removal-of-endodontic-smear-layer-using-ethylene-glycol-bis-beta-amino-ethyl-ether-n-n-n-n-tetraacetic-acid-and-citric-acid-in-primary-teeth-a-scanning-electron-microscopic-study
#20
Rahul J Hegde, Kavita Bapna
BACKGROUND: Root canal irrigants are considered momentous in their tissue dissolving property, eliminating microorganisms, and removing smear layer. The present study was aimed to compare the removal of endodontic smear layer using ethylene glycol bis (beta-amino ethyl ether)-N, N, N', N'-tetraacetic acid (EGTA) and citric acid solutions with saline as a control in primary anterior teeth. MATERIALS AND METHODS: Thirty primary anterior teeth were chosen for the study...
April 2016: Contemporary Clinical Dentistry
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