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Durgawati Patel, Puspendra Kumar, Swapnil Sharma, Jaya Dwivedi
Metformin is a widely prescribed oral anti-hyperglycemic agent used in the management of non-insulin dependent diabetes mellitus (NIDDM) or type II diabetes. This article accentuates various analytical methods viz. HPLC, HPTLC, spectrophotometric, electrochemical, capillary electrophoresis and LC-MS for the estimation of metformin in pharmaceutical formulations and in biological matrices.
March 10, 2017: Critical Reviews in Analytical Chemistry
Yam Nath Paudel, Md Rahmat Ali, Sadia Shah, Mohd Adil, Md Sayeed Akhtar, Ravisha Wadhwa, Sandhya Bawa, Manju Sharma
Thiazole derivatives are potential candidates for drug development. They can be efficiently synthesized and are extremely active against several diseases, including diabetes. In our present study, we investigated the anti-diabetic, anti-oxidant and anti-inflammatory properties of 2-[(4-Chlorobenzyl) amino]-4-methyl-1,3-thiazole-5-carboxylic acid (BAC) a new thiazole derivative, in a streptozotocin (STZ) induced neonatal model of non-insulin dependent diabetes mellitus (NIDDM) rats. Diabetes was induced by injecting STZ (100mg/kg) intraperitoneally to two days old pups...
March 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Marcus Wiemer, Sinisa Stoikovic, Alexander Samol, Zisis Dimitriadis, Juan M Ruiz-Nodar, Ralf Birkemeyer, Jacques Monsegu, Gérard Finet, David Hildick-Smith, Damras Tresukosol, Enrique Garcia Novo, Jacques J Koolen, Emanuele Barbato, Gian Battista Danzi
OBJECTIVE: To report the long-term safety and efficacy data of a third generation drug eluting stent (DES) with biodegradable polymer in the complex patient population of diabetes mellitus after a follow-up period of 5 years. BACKGROUND: After percutaneous coronary intervention patients with diabetes mellitus are under higher risk of death, restenosis and stent thrombosis (ST) compared to non-diabetic patients. METHODS: In 126 centers worldwide 3067 patients were enrolled in the NOBORI 2 registry, 888 patients suffered from diabetes mellitus (DM), 213 of them (14%) being insulin dependent (IDDM)...
February 10, 2017: Cardiovascular Diabetology
Karima Belhaj, Soumia Meftah, Laila Mahir, Fatima Lmidmani, Abdellatif Elfatimi
OBJECTIVE: Diabetic foot includes all foot abnormalities in diabetics; they are secondary to several pathophysiological mechanisms. Few studies have compared the two types of diabetes for podiatric complications. The objective of this work is to make a comparative study of podiatry profile, clinical, optical and electronic podoscopique between insulin-dependent diabetes (IDDM) and non-insulin dependent (NIDDM). MATERIALS/PATIENTS AND METHODS: This is a prospective study over one year, including diabetic patients who have been made, an optical podocopique review and static and dynamic electronics...
September 2016: Annals of Physical and Rehabilitation Medicine
Efi Koloverou, Demosthenes B Panagiotakos
Medical nutrition therapy constitutes an important lifestyle intervention in diabetes management. Several nutrition patterns have been effective in improving diabetes control, but there has been a debate about the optimal macronutrient composition in diabetes meal planning. For many years, the recommended diets for persons with and without diabetes were similar, i.e. heart-healthy and low in fat. For almost three decades, carbohydrates have been lauded, lipids demonized, and proteins considered of little importance...
2016: Review of Diabetic Studies: RDS
Kevin Phan, Jun S Kim, Nathan Lee, Parth Kothari, Samuel K Cho
STUDY DESIGN: A retrospective analysis of prospectively collected data. OBJECTIVE: Our objective was to analyze insulin-dependent and noninsulin-dependent diabetes mellitus (IDDM and NIDDM) as potential risk factors for complications, reoperations, and readmissions within 30 days following anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: ACDF is a common surgical procedure with growing utilization and good long-term outcomes...
April 1, 2017: Spine
Jorge Alberto García-Díaz, Gabriel Navarrete-Vázquez, Sara García-Jiménez, Sergio Hidalgo-Figueroa, Julio C Almanza-Pérez, Francisco Javier Alarcón-Aguilar, Jaime Gómez-Zamudio, Miguel Cruz, Maximiliano Ibarra-Barajas, Samuel Estrada-Soto
Flavonoids from medicinal plants have been used in traditional medicine to treat a variety of prevalent diseases. Flavones activate the signaling pathways promoting fuel metabolism and insulin sensitizing in hepatocytes and adipocytes, which suggests that flavones may have the potential to exert in vivo antidiabetic and antihyperlipidemic effects. Thus, the aim of the current study was to determine the antidiabetic, antihyperlipidemic and anti-inflammatory effects of tilianin in diabetic rats. Also, to understand the mechanism involved using in vitro 3T3-L1 cells and tissues from experimental animals treated with test samples through molecular profile studies...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Kyungah Jeong, So J Park, Ji H Jeon, Sa R Lee, Hye W Chung
The purpose of this study is to identify predictive markers for abnormal glucose metabolism in Korean women with polycystic ovary syndrome (PCOS). METHODSː A total of 312 PCOS patients were evaluated. All patients underwent 75-g oral glucose tolerance tests. The 2-hour plasma glucose level was used to categorize subjects as impaired glucose tolerance (IGT) or non-insulin-dependent diabetes mellitus (NIDDM). Areas under the receiver operating characteristic (ROC) curves were used to compare the power of serum markers...
August 2016: Minerva Medica
N G C van der Sande, J A N Dorresteijn, F L J Visseren, J P Dwyer, P J Blankestijn, Y van der Graaf, H L J Heerspink
AIMS: To predict individualized treatment effects of angiotensin receptor blockers (ARBs) on cardiovascular and renal complications in order to help clinicians and patients assess the benefit of treatment (or adherence) and estimate remaining disease risk. MATERIALS AND METHODS: In patients with diabetic nephropathy, the 3-year treatment effect of ARBs was predicted in terms of absolute risk reduction (ARR) for end-stage renal disease (ESRD) and cardiovascular disease (CVD; i...
June 23, 2016: Diabetes, Obesity & Metabolism
Valery Muzhikov, Elena Vershinina, Vadim Belenky, Ruslan Muzhikov
In order to assess patterns of heat sensitivity thresholds in patients with diabetes mellitus, the Akabane test was carried out on patients with insulin dependent diabetes mellitus (IDDM) (250 men and 309 women) and patients with noninsulin dependent diabetes mellitus (NIDDM) (158 men and 227 women). For comparison, a group of healthy subjects made up of 116 men and 277 women was also used. As soon as we revealed the influence of factors of pathology with a high significance level and gender and the interaction "gender*pathology", all the results are described separately for groups of men and women and for groups with IDDM and NIDDM...
2016: Acupuncture & Electro-therapeutics Research
Jianwen Li, He Lian
As a complex endocrine and metabolic disorder, type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus, NIDDM) has become a major threat to human health. Because of the heterogeneous and progressive disorders induced by insulin resistance and pancreatic b-cell dysfunction, the treatment of NIDDM is still challenging. Although antidiabetic drugs with different pharmacological mechanisms of action have been used clinically, different degrees of undesirable glucose control and the incidences of a variety of side effects, including hypoglycemia, cardiovascular complications and weight gain require the better treatment options...
June 2016: Archives of Pharmacal Research
Jun Li, Tao Chen, Kun Li, Hongtao Yan, Xiaowei Li, Yun Yang, Yulan Zhang, Bingyin Su, Fuxiang Li
Non-insulin-dependent diabetes mellitus (NIDDM) is associated with chronic inflammatory activity and disrupted insulin signaling, leading to insulin resistance (IR). The present study investigated the benefits of neurolytic celiac plexus block (NCPB) on IR in a rat NIDDM model. Goto-Kakizaki rats fed a high-fat, high-glucose diet to induce signs of NIDDM were randomly divided into NCPB and control groups; these received daily bilateral 0.5% lidocaine or 0.9% saline injections into the celiac plexus, respectively...
May 2016: Experimental and Therapeutic Medicine
Kyungah Jeong, So Y Park, Ji H Jeon, Sa R Lee, Hye W Chung
BACKGROUND: The purpose of this study is to identify predictive markers for abnormal glucose metabolism in Korean women with polycystic ovary syndrome (PCOS). METHODS: A total of 312 PCOS patients were evaluated. All patients underwent 75g oral glucose tolerance tests. The 2 hour plasma glucose level was used to categorize subjects as impaired glucose tolerance (IGT) or non-insulin-dependent diabetes mellitus (NIDDM). Areas under the receiver operating characteristic (ROC) curves were used to compare the power of serum markers...
May 6, 2016: Minerva Medica
Natalia Rudovich, Olga Pivovarova, Wolfgang Bernigau, Andrea Sparwasser, Christopher Tacke, Veronica Murahovshi, Gabriele Mertes, Andreas L Birkenfeld, Andreas Bergmann, Martin O Weickert, Andreas F Pfeiffer
BACKGROUND: Acarbose, an alpha-glucosidase inhibitor, unexpectedly reduced the incidence of hypertension and cardiovascular endpoints in the STOP-NIDDM study. Based on the growing evidence of a link between vasoregulatory peptides and metabolic traits, we hypothesized that changes of the Glycemic Index by acarbose may modulate vasoregulatory peptide levels via regulation of postprandial metabolism. METHODS: Subjects with type 2 diabetes and with metabolic syndrome were treated with acarbose (12 weeks, 300mg/d) in a double-blind, placebo-controlled, cross-over intervention...
December 2016: Minerva Endocrinologica
Finja Jockenhöfer, Knut Kröger, Joachim Klode, Regina Renner, Cornelia Erfurt-Berge, Joachim Dissemond
BACKGROUND: Necrobiosis lipoidica (NL) is a rare granulomatous inflammatory skin disease of unknown pathophysiology. Its potential association with diabetes mellitus is well known. Other relevant cofactors and comorbidities are subject to controversial debate. PATIENTS AND METHODS: DRG (diagnosis-related groups) data of all inpatients with a coded primary or secondary diagnosis of NL treated at German hospitals in 2012 were evaluated. RESULTS: Data of 262 inpatient cases with the primary or secondary diagnosis of NL were analyzed...
March 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Mathur Ritu, Johri Nandini
BACKGROUND: The prevalence of diabetes is rapidly rising all over the globe at an alarming rate. India shelters the highest number of diabetics and is thus known as the 'Diabetes Capital of the World'. The chemical management of diabetes has side effects and hence the present study was undertaken to assess the hypoglycaemic and hypolipidaemic effect of Stevia rebaudiana in patients with type 2 diabetes, non-insulin dependent diabetes mellitus (NIDDM). Its nutritional composition and use as a sweetener substitute were also assessed...
September 2016: Journal of the Science of Food and Agriculture
Jitjiroj Ittichaicharoen, Nipon Chattipakorn, Siriporn C Chattipakorn
Salivary gland dysfunction in several systemic diseases has been shown to decrease the quality of life in patients. In non-insulin dependent diabetes mellitus (NIDDM), inadequate salivary gland function has been evidenced to closely associate with this abnormal glycemic control condition. Although several studies demonstrated that NIDDM has a positive correlation with impaired salivary gland function, including decreased salivary flow rate, some studies demonstrated contradictory findings. Moreover, the changes of the salivary gland function in pre-diabetic stage known as insulin resistance are still unclear...
April 2016: Archives of Oral Biology
Megha Sharma, Seema Kohli, Agnimitra Dinda
During the study repaglinide encapsulated floating microspheres were formulated and characterized for enhancing residence time of drug in git and thereby increasing its bioavailability. Floating microspheres of ethylcellulose (EC) and hydroxypropyl methyl cellulose (HPMC) (5 and 100 cps) were prepared by emulsion solvent diffusion technique. During process optimization various parameters were studied such as: drug: polymer ratio, polymer ratio, concentration of emulsifier and stirring speed. Selected optimized formulations were studied for SEM, entrapment, floating behavior, drug release and kinetics...
November 2015: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Dawn Konrad-Martin, Curtis J Billings, Garnett P McMillan, Daniel McDermott, Jane Gordon, Donald Austin, Marilyn F Dille
OBJECTIVES: (1) To characterize the influence of type 2 diabetes mellitus (DM) on cortical auditory-evoked potentials (CAEPs) separate from the effects of normal aging, and (2) to determine whether the disease-related effects are modified by insulin dependence. DESIGN: A cross-sectional study was conducted in a large cohort of Veterans to investigate the relationships among type 2 DM, age, and CAEPs in randomly selected participants with (N = 108) and without (N = 114) the disease and who had no more than a moderate hearing loss...
May 2016: Ear and Hearing
Charles Qin, John Y S Kim, Wellington K Hsu
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: The objective of our study was to evaluate the differential impact of insulin dependence on lumbar surgery outcomes, including surgical and medical complications, total length of hospital stay, nonhome bound discharge, and unplanned readmissions. SUMMARY OF BACKGROUND DATA: Although the negative effects of diabetes mellitus (DM) on joint arthroplasty outcomes are well documented, there is a paucity of studies evaluating those on spine surgery...
June 2016: Spine
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