keyword
MENU ▼
Read by QxMD icon Read
search

Alzheimer apoe

keyword
https://www.readbyqxmd.com/read/28427934/cognitive-subtypes-of-probable-alzheimer-s-disease-robustly-identified-in%C3%A2-four-cohorts
#1
Nienke M E Scheltens, Betty M Tijms, Teddy Koene, Frederik Barkhof, Charlotte E Teunissen, Steffen Wolfsgruber, Michael Wagner, Johannes Kornhuber, Oliver Peters, Brendan I Cohn-Sheehy, Gil D Rabinovici, Bruce L Miller, Joel H Kramer, Philip Scheltens, Wiesje M van der Flier
INTRODUCTION: Patients with Alzheimer's disease (AD) show heterogeneity in profile of cognitive impairment. We aimed to identify cognitive subtypes in four large AD cohorts using a data-driven clustering approach. METHODS: We included probable AD dementia patients from the Amsterdam Dementia Cohort (n = 496), Alzheimer's Disease Neuroimaging Initiative (n = 376), German Dementia Competence Network (n = 521), and University of California, San Francisco (n = 589)...
April 17, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28419892/plasma-apolipoproteins-and-physical-and-cognitive-health-in-very-old-individuals
#2
Julia Muenchhoff, Fei Song, Anne Poljak, John D Crawford, Karen A Mather, Nicole A Kochan, Zixuan Yang, Julian N Trollor, Simone Reppermund, Kate Maston, Adam Theobald, Susanne Kirchner-Adelhardt, John B Kwok, Robyn L Richmond, Mark McEvoy, John Attia, Peter W Schofield, Henry Brodaty, Perminder S Sachdev
Apolipoproteins play a crucial role in lipid metabolism with implications in cardiovascular disease, obesity, diabetes, Alzheimer's disease, and longevity. We quantified 7 apolipoproteins in plasma in 1067 individuals aged 56-105 using immunoassays and explored relationships with APOE polymorphism ε2/3/4, vascular health, frailty, and cognition. ApoA1, ApoA2, ApoB, ApoC3, ApoE, ApoH, and ApoJ decreased from mid-life, although ApoE and ApoJ had U-shaped trends. Centenarians had the highest ApoE levels and the lowest frequency of APOE ε4 allele relative to younger groups...
March 1, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28418521/evaluation-of-amyloid-protective-factors-and-alzheimer-disease-neurodegeneration-protective-factors-in-elderly-individuals
#3
Prashanthi Vemuri, David S Knopman, Timothy G Lesnick, Scott A Przybelski, Michelle M Mielke, Jonathan Graff-Radford, Melissa E Murray, Rosebud O Roberts, Maria Vassilaki, Val J Lowe, Mary M Machulda, David T Jones, Ronald C Petersen, Clifford R Jack
Importance: While amyloid and neurodegeneration are viewed together as Alzheimer disease pathophysiology (ADP), the factors that influence amyloid and AD-pattern neurodegeneration may be considerably different. Protection from these ADP factors may be important for aging without significant ADP. Objective: To identify the combined and independent protective factors for amyloid and AD-pattern neurodegeneration in a population-based sample and to test the hypothesis that "exceptional agers" with advanced ages do not have significant ADP because they have protective factors for amyloid and neurodegeneration...
April 17, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28415654/the-associations-between-the-mapt-polymorphisms-and-alzheimer-s-disease-risk-a-meta-analysis
#4
REVIEW
Futao Zhou, Danli Wang
Published studies revealed that the microtubule-associated protein tau (MAPT) gene polymorphisms increased Alzheimer's disease (AD) risk; the associations of 4 single nucleotide polymorphisms (SNPs, rs242557G/A, rs2471738C/T, rs3785883G/A and rs1467967A/G) of the MAPT gene with AD risk, however, remain inconclusive. Here, we conducted a meta-analysis to investigate the relationship between the MAPT SNPs and AD risk. A significant association of SNP rs242557 with AD risk was found in a dominant [odds ratio (OR) = 1...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413778/family-history-and-apoe4-risk-for-alzheimer-s-disease-impact-the-neural-correlates-of-episodic-memory-by-early-midlife
#5
M N Rajah, L M K Wallace, E Ankudowich, E H Yu, A Swierkot, R Patel, M M Chakravarty, D Naumova, J Pruessner, R Joober, S Gauthier, S Pasvanis
Episodic memory impairment is a consistent, pronounced deficit in pre-clinical stages of late-onset Alzheimer's disease (AD). Individuals with risk factors for AD exhibit altered brain function several decades prior to the onset of AD-related symptoms. In the current event-related fMRI study of spatial context memory we tested the hypothesis that middle-aged adults (MA; 40-58 yrs) with a family history of late onset AD (MA+ FH), or a combined + FH and apolipoprotein E ε4 allele risk factors for AD (MA+ FH + APOE4), will exhibit differences in encoding and retrieval-related brain activity, compared to - FH - APOE4 MA controls...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28413413/the-risk-of-incident-mild-cognitive-impairment-and-progression-to-dementia-considering-mild-cognitive-impairment-subtypes
#6
Tzeyu L Michaud, Dejun Su, Mohammad Siahpush, Daniel L Murman
BACKGROUND: It remains unclear how demographic and clinical characteristics are related to the risk of incident mild cognitive impairment (MCI) by its subtypes. Moreover, the contribution of the subtypes of incident MCI to the progression to dementia remains puzzling. METHODS: We used data collected by the National Alzheimer Coordinating Center. Our analysis sample included cognitively normal subjects at baseline. The associations were examined using competing-risks survival regression models and Cox proportional hazards models...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28406978/combined-assessment-of-serum-folate-and-hemoglobin-as-biomarkers-of-brain-amyloid-%C3%AE-accumulation
#7
Takuma Yoshinaga, Hiroto Nishimata, Yoriko Kajiya, Shunichi Yokoyama
A relationship between Alzheimer's disease (AD) and folate has been reported. Amyloid positron emission tomography (PET) is currently one of the most reliable biomarkers for AD. We investigated the correlation between serum folate levels and amyloid imaging to clarify whether serum folate could be a biomarker for AD. We also examined the usefulness of a combined assessment of serum folate levels and red blood cell hemoglobin content. Apolipoprotein E (APOE) gene polymorphisms were also assessed. Serum folate levels and hemoglobin content were evaluated by receiver operating characteristic analysis for their diagnostic capability as AD biomarkers relating to brain amyloid β accumulation...
2017: PloS One
https://www.readbyqxmd.com/read/28402542/positive-affect-predicts-cerebral-glucose-metabolism-in-late-middle-aged-adults
#8
Christopher Nicholas, Siobhan M Hoscheidt, Lindsay R Clark, Annie M Racine, Sara E Berman, Rebecca L Koscik, N Maritza Dowling, Sanjay Asthana, Bradley T Christian, Mark A Sager, Sterling C Johnson
Positive affect is associated with a number of health benefits; however, few studies have examined the relationship between positive affect and cerebral glucose metabolism, a key energy source for neuronal function and a possible index of brain health. We sought to determine if positive affect was associated with cerebral glucose metabolism in late middle-aged adults (n =134). Participants completed the positive affect subscale of the Center for Epidemiological Studies of Depression Scale (CES-D) at two time points over a two-year period and underwent FDG-PET scanning...
April 11, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28399252/association-between-midlife-vascular-risk-factors-and-estimated-brain-amyloid-deposition
#9
Rebecca F Gottesman, Andrea L C Schneider, Yun Zhou, Josef Coresh, Edward Green, Naresh Gupta, David S Knopman, Akiva Mintz, Arman Rahmim, A Richey Sharrett, Lynne E Wagenknecht, Dean F Wong, Thomas H Mosley
Importance: Midlife vascular risk factors have been associated with late-life dementia. Whether these risk factors directly contribute to brain amyloid deposition is less well understood. Objective: To determine if midlife vascular risk factors are associated with late-life brain amyloid deposition, measured using florbetapir positron emission tomography (PET). Design, Setting, and Participants: The Atherosclerosis Risk in Communities (ARIC)-PET Amyloid Imaging Study, a prospective cohort study among 346 participants without dementia in 3 US communities (Washington County, Maryland; Forsyth County, North Carolina; and Jackson, Mississippi) who have been evaluated for vascular risk factors and markers since 1987-1989 with florbetapir PET scans in 2011-2013...
April 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28396874/frequency-specific-effects-of-apoe-%C3%AE%C2%B54-allele-on-resting-state-networks-in-nondemented-elders
#10
Ying Liang, Zhenzhen Li, Jing Wei, Chunlin Li, Xu Zhang, Alzheimer's Disease Neuroimaging Initiative
We applied resting-state functional magnetic resonance imaging (fMRI) to examine the Apolipoprotein E (ApoE) ε4 allele effects on functional connectivity of the default mode network (DMN) and the salience network (SN). Considering the frequency specific effects of functional connectivity, we decomposed the brain network time courses into two bands: 0.01-0.027 Hz and 0.027-0.08 Hz. All scans were acquired by the Alzheimer's Disease Neuroscience Initiative (ADNI). Thirty-two nondemented subjects were divided into two groups based on the presence (n = 16) or absence (n = 16) of the ApoE ε4 allele...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28396259/amyloid-%C3%AE-peptide-promotes-lysosomal-degradation-of-clusterin-via-sortilin-in-hippocampal-primary-neurons
#11
Yunling Wang, Xike Qin, Hemant K Paudel
Progressive accumulation of amyloid-β peptide (Aβ) in the brain is implicated as the central event in the development of Alzheimer's disease (AD). It is thought that extracellular Aβ triggers toxic signals leading to neurodegeneration. The events downstream of Aβ however are not entirely clear. Clusterin (Apo J) is one of the major risk factors for sporadic form of AD. Clusterin binds to Aβ and prevents Aβ aggregation. In addition, clusterin promotes Aβ degradation and accelerates Aβ clearance from the brain...
April 8, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28395086/regional-overlap-of-pathologies-in-lewy-body-disorders
#12
Martí Colom-Cadena, Oriol Grau-Rivera, Lluís Planellas, Catalina Cerquera, Estrella Morenas, Sergio Helgueta, Laia Muñoz, Jaime Kulisevsky, Maria Jose Martí, Eduard Tolosa, Jordi Clarimon, Alberto Lleó, Ellen Gelpi
Lewy body disorders (LBD) are common neurodegenerative diseases characterized by the presence of aggregated α-synuclein in Lewy bodies and Lewy neurites in the central and peripheral nervous systems. The brains of patients with LBD often display other comorbid pathologies, i.e. insoluble tau, β-amyloid aggregates, TAR DNA-binding protein 43 (TDP-43) deposits, and argyrophilic grain disease (AGD). The incidence and physiological relevance of these concurrent pathological findings remain controversial. We performed a semiquantitative detailed mapping of α-synuclein, tau, β-amyloid (Aβ), TDP-43, and AGD pathologies in 17 areas in 63 LBD cases (44 with Parkinson disease [PD], 28 with dementia, and 19 with dementia with Lewy bodies)...
March 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28389477/efad-transgenic-mice-as-a-human-apoe-relevant-preclinical-model-of-alzheimer-s-disease
#13
Leon M Tai, Deebika Balu, Evangelina Avila-Munoz, Laila Abdullah, Riya Thomas, Nicole Collins, Ana Carolina Valencia-Olvera, Mary Jo LaDu
Identified in 1993, APOE4 is the greatest genetic risk factor for sporadic Alzheimers disease (AD), increasing risk up to 12-fold compared to APOE3, with APOE2 decreasing AD risk. However, the functional effects of APOE4 on AD pathology remain unclear and, in some cases, controversial. In vivo progress to understand how the human (h)-APOE genotypes effect AD pathology has been limited by the lack of a tractable familial AD-transgenic (FAD-Tg) mouse model expressing h- rather than mouse (m)-APOE. The disparity between m- and h-apoE is relevant for virtually every AD-relevant pathway, including amyloid beta deposition and clearance, neuroinflammation, tau pathology, neural plasticity and cerebrovascular deficits...
April 7, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28387666/increased-carbohydrate-intake-is-associated-with-poorer-performance-in-verbal-memory-and-attention-in-an-apoe-genotype-dependent-manner
#14
Samantha L Gardener, Stephanie R Rainey-Smith, Hamid R Sohrabi, Michael Weinborn, Giuseppe Verdile, W M A D Binosha Fernando, Yen Ying Lim, Karra Harrington, Samantha Burnham, Kevin Taddei, Colin L Masters, Stuart L Macaulay, Christopher C Rowe, David Ames, Paul Maruff, Ralph N Martins
Evidence suggests that a diet low in carbohydrates can impact on cognitive performance among those with Alzheimer's disease (AD). However, there is a lack of data assessing this relationship among cognitively normal (CN) older adults at increased future risk of developing AD due to carriage of the apolipoprotein E (APOE) ɛ4 allele. We assessed the cross-sectional association between carbohydrate intake, cognitive performance, and cerebral amyloid-β (Aβ) load in CN older adults, genotyped for APOEɛ4 allele carrier status...
April 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28381516/randomized-controlled-trials-in-mild-cognitive-impairment-sources-of-variability
#15
Ronald C Petersen, Ronald G Thomas, Paul S Aisen, Richard C Mohs, Maria C Carrillo, Marilyn S Albert
OBJECTIVE: To examine the variability in performance among placebo groups in randomized controlled trials for mild cognitive impairment (MCI). METHODS: Placebo group data were obtained from 2 National Institute on Aging (NIA) MCI randomized controlled trials, the Alzheimer's Disease Cooperative Study (ADCS) MCI trial and the Alzheimer's Disease Neuroimaging Initiative (ADNI), which is a simulated clinical trial, in addition to industry-sponsored clinical trials involving rivastigmine, galantamine, rofecoxib, and donepezil...
April 5, 2017: Neurology
https://www.readbyqxmd.com/read/28381441/role-of-lrp1-in-the-pathogenesis-of-alzheimer-s-disease-evidence-from-clinical-and-preclinical-studies
#16
Mitsuru Shinohara, Masaya Tachibana, Takahisa Kanekiyo, Guojun Bu
Among the low-density lipoprotein receptor (LDLR) family members, the roles of LDLR-related protein 1 (LRP1 or LRP) in the pathogenesis of Alzheimer's disease (AD), especially late-onset AD, have been the most studied by genetic, neuropathological and biomarker analyses (clinical studies) or cellular and animal model systems (preclinical studies) over the last 25 years. Although there are some conflicting reports, accumulating evidence from preclinical studies indicates that LRP1 not only regulates the metabolism of amyloid-β peptides (Aβ) in the brain and periphery, but also maintains brain homeostasis, impairment of which likely contributes to AD development in Aβ-independent manners...
April 4, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28373057/lysophosphatidylcholine-export-by-human-abca7
#17
Maiko Tomioka, Yoshinobu Toda, Noralyn B Mañucat, Hiroyasu Akatsu, Manabu Fukumoto, Nozomu Kono, Hiroyuki Arai, Noriyuki Kioka, Kazumitsu Ueda
The ATP-binding cassette transporter A7 (ABCA7), which is highly expressed in the brain, is associated with the pathogenesis of Alzheimer's disease (AD). However, the physiological function of ABCA7 and its transport substrates remain unclear. Immunohistochemical analyses of human brain sections from AD and non-AD subjects revealed that ABCA7 is expressed in neuron and microglia cells in the cerebral cortex. The transport substrates and acceptors were identified in BHK/ABCA7 cells and compared with those of ABCA1...
March 31, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28372324/apolipoprotein-e-isoforms-differentially-regulate-alzheimer-s-disease-and-amyloid-%C3%AE-induced-inflammatory-response-in-vivo-and-in-vitro
#18
Evan Dorey, Michelle Bamji-Mirza, Dema Najem, Yan Li, Hong Liu, Debbie Callaghan, Douglas Walker, Lih-Fen Lue, Danica Stanimirovic, Wandong Zhang
Neuroinflammation plays a critical role in neuronal dysfunction and death of Alzheimer's disease (AD). ApoE4 is a major risk factor of AD, while ApoE2 is neuroprotective. Little is known about the roles of ApoE isoforms in the neuroinflammation seen in AD. Their roles and mechanisms in Aβ-induced/neuroinflammation were investigated in this study using in vivo and in vitro models. Rat astrocytes were treated with lipid-poor recombinant hApoE or/and Aβ42. Mouse astrocyte lines-expressing lipidated hApoE were treated with Aβ42 or/and vitamin D receptor (VDR) agonist, 1α,25-dihydroxyvitamin D3...
March 29, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28369008/genetic-ancestry-and-susceptibility-to-late-onset-alzheimer-s-disease-load-in-the-admixed-colombian-population
#19
Diana J Moreno, Sebastián Pino, Ángela Ríos, Francisco Lopera, Henry Ostos, Marc Via, Gabriel Bedoya
INTRODUCTION: Differences in the prevalence of dementia among populations and in the effect of apolipoprotein E (APOE) on the emergence of Alzheimer's disease (AD), which is the main type of dementia, have been reported. METHODS: This study estimated the ancestry of a group of individuals with late-onset Alzheimer's disease (LOAD) (N=280) and established whether there were any differences when compared with a control group (N=357) in a sample of the Colombian population...
March 31, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28366823/redox-status-of-serum-apolipoprotein-e-and-its-impact-on-hdl-cholesterol-levels
#20
Kazuyoshi Yamauchi, Yuka Ebihara, Yasushi Kawakami
BACKGROUND: Apolipoprotein E (apoE) is closely involved in the pathogenesis of apoE-related diseases, such as Alzheimer's disease and cardiovascular disease. The redox modulation of cysteine-thiols in a protein is involved in various pathophysiological regulations; however, that of apoE has not been studied in detail. Herein, we devised an analytical method to determine the redox status of serum apoE and assessed its relation to serum cholesterol levels and apoE phenotype. METHODS: The present method was based on a band shift assay, using a photocleavable maleimide-conjugated polyethylene glycol...
March 30, 2017: Clinical Biochemistry
keyword
keyword
36392
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"