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https://www.readbyqxmd.com/read/29766828/protective-effects-of-crocetin-on-depression-like-behavior-induced-by-immobilization-in-rat
#1
Tahereh Farkhondeh, Saeed Samarghandian, Fariborz Samini, Ali Rajabpour Sanati
Crocetin, an active ingredient of saffron, has been recognized as a potent antioxidant. Plant extracts or their components may be useful in ameliorating the various diseases, including neurodegenerative disorders. This study investigated the effects of crocetin on oxidative damage induced by chronic restraint stress in the rat brain. For this reason, rats were kept in the restrainers for 1 hour every day, for 21 consecutive days. The animals were injected of crocetin (20, 40, 60 mg/kg) or vehicle daily for 21 days...
May 15, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29747750/crocus-sativus-a-natural-food-coloring-and-flavoring-has-potent-anti-tumor-properties
#2
REVIEW
Zahra Khorasanchi, Mojtaba Shafiee, Farnoush Kermanshahi, Majid Khazaei, Mikhail Ryzhikov, Mohammad Reza Parizadeh, Behnoush Kermanshahi, Gordon A Ferns, Amir Avan, Seyed Mahdi Hassanian
BACKGROUND: Saffron, the dried stigmas of Crocus sativus L., is a highly valued agricultural product that is used mainly as a food coloring and flavoring agent. Three main secondary metabolites of Crocus sativus including crocin, picrocrocin, and safranal are responsible for the color, the bitter taste and for the odor and aroma, respectively. As a component of traditional medicine, saffron has been utilized as a medicinal herb for treating various ailments including cramps, asthma, liver disease, menstruation disorders, pain, and in the pathogenesis of cancer...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29747375/expression-and-interaction-analysis-among-saffron-aldhs-and-crocetin-dialdehyde
#3
Lourdes Gómez-Gómez, Luis F Pacios, Araceli Diaz-Perales, María Garrido-Arandia, Javier Argandoña, Ángela Rubio-Moraga, Oussama Ahrazem
In saffron, the cleavage of zeaxanthin by means of CCD2 generates crocetin dialdehyde, which is then converted by an unknown aldehyde dehydrogenase to crocetin. A proteome from saffron stigma was released recently and, based on the expression pattern and correlation analyses, five aldehyde dehydrogenases (ALDHs) were suggested as possible candidates to generate crocetin from crocetin dialdehydes. We selected four of the suggested ALDHs and analyzed their expression in different tissues, determined their activity over crocetin dialdehyde, and performed structure modeling and docking calculation to find their specificity...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29710463/a-comprehensive-review-on-regulatory-effects-of-crocin-on-ischemia-reperfusion-injury-in-multiple-organs
#4
REVIEW
Ghaidafeh Akbari, Seyyed Ali Mard, Ali Veisi
Ischemia-reperfusion (I/R) injury affects o2 -dependent organs including liver, kidneys, heart, brain, and intestine. I/R injury is described as the cellular injury in an organ caused by ischemia and then further aggravated during the reperfusion due to intracellular alterations. It is a process that happens in clinical settings such as organ transplantation, reperfusion after thrombolytic therapy, and coronary angioplasty. Crocus sativus L. known as saffron used in folk medicine for its beneficial effects...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29692651/influence-of-crocetin-on-high-cholesterol-diet-induced-atherosclerosis-in-rats-via-anti-oxidant-activity-together-with-inhibition-of-inflammatory-response-and-p38-mapk-signaling-pathway
#5
Shu-Ling Diao, Jing-Wu Sun, Bao-Xin Ma, Xiao-Mei Li, Dong Wang
The present study aimed to investigate the effect and possible mechanism of action of crocetin on the high cholesterol diet (HCD) induced atherosclerosis rat. The Wistar rats were used in the current investigation. The rats were divided into following group, Group I: control, Group II: HCD induced AS, Group III: AS + crocetin (25 mg/kg), Group IV: AS + crocetin (50 mg/kg) and Group V: AS + Simvastatin, respectively. AS was induced in the rats using the vitamin D3 and HCD. The rats received the pre-determined treatment for the 10 weeks...
March 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29622218/quality-assessment-of-saffron-crocus-sativus-l-extracts-via-uhplc-dad-ms-analysis-and-detection-of-adulteration-using-gardenia-fruit-extract-gardenia-jasminoides-ellis
#6
Benjamin Moras, Loïc Loffredo, Stéphane Rey
A new UHPLC-DAD-MS method based on a Core-Shell particles column was developed to realize the rapid separation of saffron stigma metabolites (Crocus sativus L.). A single separation of 35 compounds included cis and trans-crocetin esters (crocins), cis-crocetin, trans-crocetin, kaempferol derivatives, safranal, and picrocrocin from pure saffron stigmas. This method permitted the detection of 11 picrocrocin derivatives as the typical group of compounds from saffron as well as the detection of gardenia-specific compounds as typical adulterant markers...
August 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29486335/crocin-attenuates-cyclophosphamide-induced-testicular-toxicity-by-preserving-glutathione-redox-system
#7
Ajay Godwin Potnuri, Lingesh Allakonda, Mangala Lahkar
Chemotherapy induced testicular toxicity is an emerging reason for azoospermia and impotency in males. Cyclophosphamide (CP) is a widely used chemotherapeutic agent to manage neoplastic and non-neoplastic autoimmune diseases. Testicular toxicity along with bladder and hepatotoxicity are its widely reported adverse effects. Crocin (CR) is the digentiobiosyl ester of crocetin, found in the fruits of gardenia (Gardenia jasminoides E.) and dried stigmas of saffron (Crocus sativus L.) possess antioxidant, anti-depressant, anti-tumor and aphrodisiac properties...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29434251/transcriptome-analysis-in-tissue-sectors-with-contrasting-crocins-accumulation-provides-novel-insights-into-apocarotenoid-biosynthesis-and-regulation-during-chromoplast-biogenesis
#8
Oussama Ahrazem, Javier Argandoña, Alessia Fiore, Carolina Aguado, Rafael Luján, Ángela Rubio-Moraga, Mónica Marro, Cuauhtémoc Araujo-Andrade, Pablo Loza-Alvarez, Gianfranco Diretto, Lourdes Gómez-Gómez
Crocins, the red soluble apocarotenoids of saffron, accumulate in the flowers of Crocus species in a developmental and tissue-specific manner. In Crocus sieberi, crocins accumulate in stigmas but also in a distinct yellow tepal sector, which we demonstrate contains chromoplast converted from amyloplasts. Secondary metabolites were analysed by LC-DAD-HRMS, revealing the progressive accumulation of crocetin and crocins in the yellow sector, which were also localized in situ by Raman microspectroscopy. To understand the underlying mechanisms of crocin biosynthesis, we sequenced the C...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29392745/latest-advances-in-the-extraction-and-determination-of-saffron-apocarotenoids
#9
REVIEW
Anastasia Kyriakoudi, Maria Z Tsimidou
Saffron, the dried red stigmas of Crocus sativus L. plant, is the most expensive spice in the world. It is highly valued not only for the color and flavor that exerts to various foods and drinks but also for its functional properties. Various classes of apocarotenoids such as crocetin sugar esters, picrocrocin and safranal are responsible for these characteristics. In the present review, the evolution of the methods proposed by the ISO standard for extraction and determination of saffron apocarotenoids since 1980 is presented in parallel to other approaches proposed by various scientists to overcome limitations of the standard...
February 2, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29306211/a-comprehensive-review-of-the-pharmacological-potential-of-crocus-sativus-and-its-bioactive-apocarotenoids
#10
REVIEW
Syed Imran Bukhari, Mahreen Manzoor, M K Dhar
Crocus sativus is an herbaceous plant that belongs to family Iridaceae. It is commonly known as saffron and has been used for medicinal purposes since many centuries in India and other parts of the world. Saffron of commercial importance comprises of dried stigmas of the plant and is rich in flavonoids, vitamins, and carotenoids. Carotenoids represent the main components of saffron and their cleavage results in the formation of apocarotenoids such as crocin, picrocrocin, and safranal. Studies conducted during the past two decades have revealed the immense therapeutic potential of saffron...
February 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29295497/saffron-an-old-medicinal-plant-and-a-potential-novel-functional-food
#11
REVIEW
María José Bagur, Gonzalo Luis Alonso Salinas, Antonia M Jiménez-Monreal, Soukaina Chaouqi, Silvia Llorens, Magdalena Martínez-Tomé, Gonzalo L Alonso
The spice saffron is made from the dried stigmas of the plant Crocus sativus L. The main use of saffron is in cooking, due to its ability to impart colour, flavour and aroma to foods and beverages. However, from time immemorial it has also been considered a medicinal plant because it possesses therapeutic properties, as illustrated in paintings found on the island of Santorini, dated 1627 BC. It is included in Catalogues of Medicinal Plants and in the European Pharmacopoeias, being part of a great number of compounded formulas from the 16th to the 20th centuries...
December 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29237384/ros-scavenging-and-anti-tyrosinase-properties-of-crocetin-on-b16f10-murine-melanoma-cells
#12
Seyed Hamed Hashemi-Shahri, Alireza Golshan, Seyed Ahmad Mohajeri, Javad Baharara, Elaheh Amini, Farzaneh Salek, Amirhossein Sahebkar, Zahra Tayarani-Najaran
BACKGROUND: Crocus sativus (Iridaceae) has been traditionally used in the Iranian folk medicine and as a culinary additive. Major components of the plant that are responsible for biological properties are saffranal, crocin, picrocrocin and crocetin. Although the level of crocetin is not high, some of the important activities of saffron such as antioxidant activity have been attributed to crocetin. OBJECTIVE: In the present study, we investigated the effects of crocetin on melanogenesis in B16 melanoma cells...
December 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29217355/crocetin-attenuates-spared-nerve-injury-induced-neuropathic-pain-in-mice
#13
Xiaolei Wang, Guangqing Zhang, Yong Qiao, Chang Feng, Xin Zhao
Crocetin is the main component of saffron and exhibits anti-oxidative and anti-inflammatory effects. Neuroinflammation and oxidative stress have been recognized to play a crucial role in the pathogenesis of neuropathic pain. We investigated the effect of crocetin in a mouse model with neuropathic pain induced by spared nerve injury (SNI). Crocetin was intrathecally perfused at various doses for up to 12 days starting 3 days before the surgery. Behavioral tests were performed to determine pain sensitivity. The concentrations of proinflammatory cytokines tumor necrosis factor (TNF-α) and interleukin-1β (IL-1β) were measured to assess neuroinflammation...
December 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29147836/effects-of-saffron-and-its-constituents-crocin-1-crocin-2-and-crocetin-on-%C3%AE-synuclein-fibrils
#14
Eiji Inoue, Yasuharu Shimizu, Ryo Masui, Tomomi Hayakawa, Tomoe Tsubonoya, Satoko Hori, Keiichi Sudoh
Saffron, the stigma of Crocus sativus Linné (Iridaceae family), has been known to inhibit aggregation of β-amyloid, a nerve tissue protein. α-Synuclein (αS) is a 140-amino acid protein found abundantly in various regions of the brain. Its abnormal aggregation and accumulation in nerve tissue are said to cause neurodegenerative diseases such as Parkinson's disease, Lewy body dementia, and multiple-system atrophy. This study (part of this study was presented at the 137th Annual Meeting of the Pharmaceutical Society of Japan) examined the effects of saffron, its constituents (crocin-1, crocin-2, crocetin, and safranal), and crocetin structural analogs (hexadecanedioic acid, norbixin, and trans, trans-muconic acid) on αS aggregation, and αS fibril dissociation...
January 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29136374/saffron-against-components-of-metabolic-syndrome-current-status-and-prospective
#15
REVIEW
Mojtaba Shafiee, Nazanin Sadat Aghili Moghaddam, Mohammad Nosrati, Mahsa Tousi, Amir Avan, Mikhail Ryzhikov, Mohammad Reza Parizadeh, Hamid Fiuji, Majid Rajabian, Amirhossein Bahreyni, Majid Khazaei, Seyed Mahdi Hassanian
Saffron, the dried stigmas of Crocus sativus L., is mainly used as a food coloring and flavoring agent. This agricultural product is used in traditional medicine for the treatment of several diseases including asthma, liver disease, menstruation disorders, and, of special interest in this review, metabolic syndrome. Saffron and its active components including crocin, crocetin, and safranal are potential therapeutic candidates for attenuating MetS complications including hypertension, hyperglycemia, obesity, and dyslipidemia...
December 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29134501/pharmacokinetic-properties-of-saffron-and-its-active-components
#16
Azar Hosseini, Bibi Marjan Razavi, Hossein Hosseinzadeh
Saffron as a medicinal plant has many therapeutic effects. Phytochemical studies have reported that saffron is composed of at least four active ingredients which include crocin, crocetin, picrocrocin and safranal. The carotenoids of saffron are sensitive to oxygen, light, heat and enzymatic oxidization. However, regulation of these factors is required for saffron quality. Some pharmacologic effects of saffron and its active compounds include cardioprotective, neuroprotective, memory enhancer, antidepressant and anxiolytic...
November 13, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29093644/synergistic-anticancer-effect-of-combined-crocetin-and-cisplatin-on-kyse-150-cells-via-p53-p21-pathway
#17
Sheng Li, Xiu-Yin Shen, Ting Ouyang, Yuhua Qu, Tao Luo, Hua-Qiao Wang
Background: More than 400,000 patients die from esophageal cancer annually. Considerable efforts have been made to develop new and effective treatments, one of which is directed toward herbal medication. Crocetin is a natural carotenoid dicarboxylic acid isolated from the Chinese herb saffron. We recently reported on the anticancer effects of saffron. This study aimed to determine whether crocetin combined cisplatin has synergistic effect in KYSE-150 cells and explore the underlying mechanism...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28981773/evolutionarily-distinct-carotenoid-cleavage-dioxygenases-are-responsible-for-crocetin-production-in-buddleja-davidii
#18
Oussama Ahrazem, Gianfranco Diretto, Javier Argandoña, Ángela Rubio-Moraga, José Manuel Julve, Diego Orzáez, Antonio Granell, Lourdes Gómez-Gómez
Crocetin, one of the few colored apocarotenoids known in nature, is present in flowers and fruits and has long been used medicinally and as a colorant. Saffron is the main source of crocetin, although a few other plants produce lower amounts of this apocarotenoid. Notably, Buddleja davidii accumulates crocetin in its flowers. Recently, a carotenoid dioxygenase cleavage enzyme, CCD2, has been characterized as responsible for crocetin production in Crocus species. We searched for CCD2 homologues in B. davidii and identified several CCD enzymes from the CCD1 and CCD4 subfamilies...
July 20, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28970011/crocetin-inhibits-the-proliferation-migration-and-tgf-%C3%AE-2-induced-epithelial-mesenchymal-transition-of-retinal-pigment-epithelial-cells
#19
Hui-Fang Wang, Jing-Xue Ma, Qing-Li Shang, Jian-Bin An, Hai-Ting Chen
Retinal pigment epithelial (RPE) cells, the major cell type in the fibrotic membrane of proliferative vitreoretinopathy, display enhanced proliferative and migratory capacities and epithelial-mesenchymal transition (EMT). In this study, we investigated the potential impact of crocetin on the proliferation, migration and EMT of cultured ARPE-19 cells. The cells were treated with crocetin alone or in combination with transforming growth factor-β2 (TGF-β2). Cell proliferation was examined using the CCK-8 assay...
November 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28852439/crocin-has-anti-inflammatory-and-protective-effects-in-ischemia-reperfusion-induced-renal-injuries
#20
Zeynab Mohamadi Yarijani, Ali Pourmotabbed, Tayebeh Pourmotabbed, Houshang Najafi
OBJECTIVES: Crocus sativus (saffron) has been widely used in traditional medicine. It has also been found to possess many beneficial properties in modern medicine. The most important ingredients of saffron are crocin, crocetin, safranal, and picrocrocin. This study evaluated the protective effects of crocin against the inflammation, oxidative stress, and functional disturbances of the kidney induced by renal ischemia/reperfusion (I/R). MATERIALS AND METHODS: Different doses of crocin (0, 100, 200, and 400 mg/kg) were administered intraperitoneally 30 min before I/R...
July 2017: Iranian Journal of Basic Medical Sciences
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