keyword
https://read.qxmd.com/read/36566240/dietary-supplement-mislabelling-case-study-on-selected-slimming-products-by-developing-a-green-isocratic-hplc-method-for-their-quality-control
#21
JOURNAL ARTICLE
Noha F El-Azab, Sarah H Abdelaal, Said A Hassan, Amira M El-Kosasy
Nowadays, a huge population consumes Dietary supplements for losing weight. Products are often claimed as botanical blends, yet they aren't necessarily safe. Misleading labels are also very common. Thus, validated analytical methods for a wide range of slimming compounds are highly needed. Herein, we present a simple HPLC/PDA method for the quantitation of seven popular slimming ingredients. Studied compounds were Caffeine, Raspberry Ketone, trans-Resveratrol, p-Synephrine, p-Octopamine, p-Hordenine and 2-phenethylamine...
December 24, 2022: Scientific Reports
https://read.qxmd.com/read/36468583/the-signatures-of-liver-metabolomics-and-gut-microbiota-in-high-fat-diet-fed-mice-supplemented-with-rhododendrol
#22
JOURNAL ARTICLE
Xiaoping Li, Yu Wang, Chengwei Yu, Yexuan Yao, Xi Chen, Ze-Yuan Deng, Zhao Yao, Ting Luo
As aromatic compounds found within red fruits and berries, raspberry ketones (RK) have the potential for nonalcoholic fatty liver disease (NAFLD) amelioration. However, the mechanism of RK on NAFLD is unclear, and their bioactive metabolite is unknown. As the major metabolites of RK that are mainly distributed in the liver, rhododendrol (RHO) is used in our current study to test whether RHO accounts for the beneficial effect of RK on NAFLD and the underlying mechanism. In a 16-week trial, RHO significantly decreased final body weight, improved serum lipid profile and ameliorated liver inflammation...
December 5, 2022: Food & Function
https://read.qxmd.com/read/36460224/metabolic-gene-signature-in-white-adipose-tissue-of-oral-doses-raspberry-ketone-4-4-hydroxyphenyl-2-butanone-that-prevent-diet-induced-weight-gain-and-induce-loss-of-righting-reflex
#23
JOURNAL ARTICLE
Dushyant Kshatriya, Lihong Hao, Nicholas T Bello
Raspberry ketone (RK; [4-(4-hydroxyphenyl)-2-butanone]) is a synthetic flavoring agent and dietary supplement for weight control. This study investigated the metabolic signature of oral doses of RK that prevent weight gain or promote loss of righting reflex (LORR) in C57Bl/6J mice. Daily RK 200 mg/kg prevented high-fat diet (HFD; 45% Kcal fat) fed weight gain (∼8% reduction) over 35 days. RNA-seq of inguinal white adipose tissue (WAT) performed in males revealed 12 differentially expressed genes...
November 29, 2022: Food and Chemical Toxicology
https://read.qxmd.com/read/36341819/ethnopharmacology-of-rubus-idaeus-linnaeus-a-critical-review-on-ethnobotany-processing-methods-phytochemicals-pharmacology-and-quality-control
#24
REVIEW
Yi Tao, Jiaqi Bao, Fei Zhu, Meiling Pan, Qing Liu, Ping Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Rubus idaeus Linnaeus (RI) is a Chinese herbal medicine that has been widely used in China for a long time to reinforce the kidney, nourish the liver, improve vision, and arrest polyuria. AIM OF THE STUDY: This work aims to evaluate the recent progress of the chemical composition, pharmacological activity, pharmacokinetics, metabolism, and quality control and of Rubus idaeus, which focuses on the insufficiency of existing research and will shed light on future studies of Rubus idaeus...
February 10, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/35687750/identification-of-gut-bacterial-enzymes-for-keto-reductive-metabolism-of-xenobiotics
#25
JOURNAL ARTICLE
Liangyu Qian, Huanrong Ouyang, Lois Gordils-Valentin, Joshua Hong, Arul Jayaraman, Xuejun Zhu
Human gastrointestinal microbiota are known for the keto-reductive metabolism of small-molecule pharmaceuticals; however, the responsible enzymes remain poorly understood. Through in vitro biochemical assays, we report the identification of enzymes encoded in the genome of Clostridium bolteae that can reduce the ketone groups of nabumetone, hydrocortisone, and tacrolimus. The homologues to a newly identified enzyme (i.e., DesE) are potentially widely distributed in the gut microbiome. The selected enzymes display different levels of activities against additional chemicals such as two dietary compounds (i...
July 15, 2022: ACS Chemical Biology
https://read.qxmd.com/read/35638340/a-whiff-of-the-future-functions-of-phenylalanine-derived-aroma-compounds-and-advances-in-their-industrial-production
#26
REVIEW
Oded Skaliter, Yarin Livneh, Shani Agron, Sharoni Shafir, Alexander Vainstein
Plants produce myriad aroma compounds-odorous molecules that are key factors in countless aspects of the plant's life cycle, including pollinator attraction and communication within and between plants. For humans, aroma compounds convey accurate information on food type, and are vital for assessing the environment. The phenylpropanoid pathway is the origin of notable aroma compounds, such as raspberry ketone and vanillin. In the last decade, great strides have been made in elucidating this pathway with the identification of numerous aroma-related biosynthetic enzymes and factors regulating metabolic shunts...
September 2022: Plant Biotechnology Journal
https://read.qxmd.com/read/35629916/metabolism-of-enantiomers-of-rhododendrol-in-human-skin-homogenate
#27
JOURNAL ARTICLE
Lihao Gu, Kazuhisa Maeda
We reported that raspberry ketone (RK) is produced from rhododendrol (RD) in excised mouse skin. We confirmed that RK is also produced from RD in human skin homogenates. We also observed more conversion of RD to RK when the oxidized form of nicotinamide adenine dinucleotide (NAD+ ), a coenzyme of alcohol dehydrogenase (ADH), was added to human skin homogenates. Chiral column analysis of the consumption of RD enantiomers in human skin homogenates also showed that more of the R enantiomers of RD remained than the S enantiomers of RD...
May 3, 2022: Metabolites
https://read.qxmd.com/read/35488673/raspberry-ketone-promotes-fndc5-protein-expression-via-ho-1-upregulation-in-3t3-l1-adipocytes
#28
JOURNAL ARTICLE
Yung-Chieh Tsai, Jung-Hua Chen, Yen-Mei Lee, Mao-Hsiung Yen, Pao-Yun Cheng
Obesity is a global health problem and a risk factor for cardiovascular diseases and cancers. Exercise is an effective intervention to combat obesity. Fibronectin type III domain containing protein 5 (FNDC5)/irisin, a myokine, can stimulate the browning of white adipose tissue by increasing uncoupling protein 1 (UCP1) expression, and therefore may represent a link between the beneficial effects of exercise and improvement in metabolic diseases. Thus, upregulating the endogenous expression of FNDC5/irisin by administering medication would be a good approach for treating obesity...
March 2022: Chinese Journal of Physiology
https://read.qxmd.com/read/35452838/a-comprehensive-phylogeny-helps-clarify-the-evolutionary-history-of-host-breadth-and-lure-response-in-the-australian-dacini-fruit-flies-diptera-tephritidae
#29
JOURNAL ARTICLE
M L Starkie, S L Cameron, M N Krosch, M J Phillips, J E Royer, M K Schutze, F Strutt, A D Sweet, M P Zalucki, A R Clarke
The tribe Dacini (Diptera: Tephritidae) contains over 930 recognised species and has been widely studied due to the economic importance of some taxa, such as the Oriental fruit fly Bactrocera dorsalis. Despite the attention this group has received, very few phylogenetic reconstructions have comprehensively sampled taxa from a single biogeographic region, thereby limiting our capacity to address more targeted evolutionary questions. To study the evolution of diet breadth and male lure response, two key traits fundamental to understanding dacine diversity and the biology of pest taxa, we analysed 273 individuals representing 144 described species from Australia (80% continental coverage), the Pacific, and select close relatives from South-east Asia to estimate a dated molecular phylogenetic reconstruction of the Dacini...
July 2022: Molecular Phylogenetics and Evolution
https://read.qxmd.com/read/35049959/effect-of-issatchenkia-terricola-wjl-g4-on-deacidification-characteristics-and-antioxidant-activities-of-red-raspberry-wine-processing
#30
JOURNAL ARTICLE
Hongying He, Yuchen Yan, Dan Dong, Yihong Bao, Ting Luo, Qihe Chen, Jinling Wang
Our previous study isolated a novel Issatchenkia terricola WJL-G4, which exhibited a potent capability of reducing citric acid. In the current study, I . terricol a WJL-G4 was applied to decrease the content of citric acid in red raspberry juice, followed by the red raspberry wine preparation by Saccharomyces cerevisiae fermentation, aiming to investigate the influence of I . terricola WJL-G4 on the physicochemical properties, organic acids, phenolic compounds and antioxidant activities during red raspberry wine processing...
December 27, 2021: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/34941428/raspberry-rubus-idaeus-l-a-promising-alternative-in-the-treatment-of-hyperglycemia-and-dyslipidemias
#31
JOURNAL ARTICLE
Norma Piña-Contreras, Alma Gabriela Martínez-Moreno, Jessica Del Pilar Ramírez-Anaya, Ana Cristina Espinoza-Gallardo, Elia Herminia Miramontes Valdés
Raspberry production and consumption have increased in recent years due to its polyphenol content such as anthocyanins and ketones, bioactive compounds that have been studied to reduce blood glucose levels and stabilize the blood lipid profile. The objective of this study was to systematically recover and review scientific evidence regarding the consumption of raspberry or its bioactive compounds and the action mechanisms involved in the hypoglycemic and lipid-lowering effects they present. Original articles from in vitro and in vivo enzyme inhibition studies, animal models, and human clinical studies were compiled in PubMed, Web of Science, and Science Direct databases...
December 23, 2021: Journal of Medicinal Food
https://read.qxmd.com/read/34913499/potential-metabolic-activities-of-raspberry-ketone
#32
REVIEW
Xiaoping Li, Teng Wei, Min Wu, Fang Chen, Peng Zhang, Ze-Yuan Deng, Ting Luo
Novel food and food compounds interventions have attracted a lot of attention nowadays for the prevention and treatment of metabolic diseases. Raspberry ketone (RK) is aromatic compound found within red fruits and berries, has been used as an over-the-counter product for weight loss. However, actually, the effect of RK on weight loss is still controversial, and the mechanism is largely unknown. Besides, in vivo and in vitro studies have demonstrated the beneficial effect of RK on the development of other metabolic diseases...
January 2022: Journal of Food Biochemistry
https://read.qxmd.com/read/34887778/reduced-body-fat-and-epididymal-adipose-apelin-expression-associated-with-raspberry-ketone-4-4-hydroxyphenyl-2-butanone-weight-gain-prevention-in-high-fat-diet-fed-mice
#33
JOURNAL ARTICLE
Lihong Hao, Nicholas T Bello
Raspberry ketone [4-(4-hydroxyphenyl)-2-butanone] is a natural aromatic compound found in raspberries and other fruits. Raspberry ketone (RK) is synthetically produced for use as a commercial flavoring agent. In the United States and other markets, it is sold as a dietary supplement for weight control. The potential of RK to reduce or prevent excessive weight gain is unclear and could be a convergence of several different actions. This study sought to determine whether acute RK can immediately delay carbohydrate hyperglycemia and reduce gastrointestinal emptying...
2021: Frontiers in Physiology
https://read.qxmd.com/read/34712844/high-yield-one-pot-biosynthesis-of-raspberry-ketone-a-high-value-fine-chemical
#34
JOURNAL ARTICLE
Simon J Moore, Tommaso Tosi, David Bell, Yonek B Hleba, Karen M Polizzi, Paul S Freemont
Cell-free extract and purified enzyme-based systems provide an attractive solution to study biosynthetic strategies towards a range of chemicals. 4-(4-hydroxyphenyl)-butan-2-one, also known as raspberry ketone, is the major fragrance component of raspberry fruit and is used as a natural additive in the food and sports industry. Current industrial processing of the natural form of raspberry ketone involves chemical extraction from a yield of ∼1-4 mg kg-1 of fruit. Due to toxicity, microbial production provides only low yields of up to 5-100 mg L-1 ...
2021: Synthetic Biology
https://read.qxmd.com/read/34517584/development-and-validation-of-a-micro-quechers-method-with-high-throughput-enhanced-matrix-removal-followed-with-uhplc-qqq-ms-ms-for-analysis-of-raspberry-ketone-related-phenolic-compounds-in-adipose-tissues
#35
JOURNAL ARTICLE
Bo Yuan, Danyue Zhao, Weiting Lyu, Zhiya Yin, Dushyant Kshatriya, James E Simon, Nicholas T Bello, Qingli Wu
Raspberry ketone (RK) is a major flavor compound in red raspberries, and it has been marketed as a popular weight-loss dietary supplement with high potential in accumulating in fatty tissues. However, challenges in extracting and characterizing RK and its associated phenolic compounds in fatty tissues persist due to the complex matrix effect. In this work, we reported a high-throughput sample preparation method for RK and 25 related phenolic compounds in white adipose tissues using an improved micro-scale QuEChERS (quick, efficient, cheap, easy, rugged and safe) approach with enhanced matrix removal (EMR)-lipid cleanup in 96-well plates, followed by UHPLC-QqQ-MS/MS analysis...
December 1, 2021: Talanta
https://read.qxmd.com/read/34480052/raspberry-ketone-diet-supplement-reduces-attraction-of-sterile-male-queensland-fruit-fly-to-cuelure-by-altering-expression-of-chemoreceptor-genes
#36
JOURNAL ARTICLE
Mohammed Abul Monjur Khan, Nandan P Deshpande, Lucas A Shuttleworth, Terry Osborne, Damian Collins, Marc R Wilkins, Geoff M Gurr, Olivia L Reynolds
Sterile male Queensland fruit fly, Bactrocera tryoni (Froggatt), fed as immature adults on the plant compound raspberry ketone (RK), show a reduced attraction to cuelure, a synthetic analogue of RK used as an attractant in Male Annihilation Technique. We hypothesized the reduced attraction of RK-fed adult males to cuelure may be a consequence of altered expression of chemoreception genes. A Y-tube olfactometer assay with RK-fed and RK-unfed sterile B. tryoni males tested the subsequent behavioural response to cuelure...
September 3, 2021: Scientific Reports
https://read.qxmd.com/read/34442697/does-organic-farming-increase-raspberry-quality-aroma-and-beneficial-bacterial-biodiversity
#37
JOURNAL ARTICLE
Daniela Sangiorgio, Antonio Cellini, Francesco Spinelli, Brian Farneti, Iuliia Khomenko, Enrico Muzzi, Stefano Savioli, Chiara Pastore, María Teresa Rodriguez-Estrada, Irene Donati
Plant-associated microbes can shape plant phenotype, performance, and productivity. Cultivation methods can influence the plant microbiome structure and differences observed in the nutritional quality of differently grown fruits might be due to variations in the microbiome taxonomic and functional composition. Here, the influence of organic and integrated pest management (IPM) cultivation on quality, aroma and microbiome of raspberry ( Rubus idaeus L.) fruits was evaluated. Differences in the fruit microbiome of organic and IPM raspberry were examined by next-generation sequencing and bacterial isolates characterization to highlight the potential contribution of the resident-microflora to fruit characteristics and aroma...
July 29, 2021: Microorganisms
https://read.qxmd.com/read/34407814/correction-to-refactoring-of-a-synthetic-raspberry-ketone-pathway-with-ecoflex
#38
Simon J Moore, Yonek B Hleba, Sarah Bischoff, David Bell, Karen M Polizzi, Paul S Freemont
No abstract text is available yet for this article.
August 18, 2021: Microbial Cell Factories
https://read.qxmd.com/read/34386350/production-of-raspberry-ketone-by-redirecting-the-metabolic-flux-to-the-phenylpropanoid-pathway-in-tobacco-plants
#39
JOURNAL ARTICLE
Takao Koeduka, Sachiho Takarada, Koya Fujii, Akifumi Sugiyama, Kazufumi Yazaki, Masahiro Nishihara, Kenji Matsui
Raspberry ketone is one of the characteristic flavors of raspberry fruits, and it is an important and expensive ingredient in the flavor and fragrance industries. It is present at low levels in plant tissues, and its occurrence is limited to a few taxa. In this context, the stable production of nature-identical raspberry ketone using heterologous synthesis in plants hosts has recently garnered the attention of plant biochemists. In this study, we demonstrate the rational switching of the metabolic flow from anthocyanin pigments to volatile phenylbutanoid production via the phenylpropanoid pathway...
December 2021: Metabolic Engineering Communications
https://read.qxmd.com/read/34327914/-overexpression-of-a-fusion-protein-of-4-coumaroyl-coa-ligase-and-polyketide-synthase-for-raspberry-ketone-production-in-chlamydomonas-reinhardtii
#40
JOURNAL ARTICLE
Wenqing Niu, Hangtao Wei, Feiyan Xue, Mingfeng Yang
Raspberry ketones have important therapeutic properties such as anti-influenza and prevention of diabetes. In order to obtain raspberry ketone from Chlamydomonas reinhardtii, two enzymes catalyzing the last two steps of raspberry ketone synthesis, i.e. 4-coumaryl-CoA ligase (4CL) and polyketide synthase (PKS1), were fused using a glycine-serine-glycine (GSG) tripeptide linker to construct an expression vector pChla-4CL-PKS1. The fusion gene 4CL-PKS1 driven by a PSAD promoter was transformed into a wild-type (CC125) and a cell wall-deficient C...
July 25, 2021: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
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