keyword
MENU ▼
Read by QxMD icon Read
search

glycolic acid

keyword
https://www.readbyqxmd.com/read/28528117/composite-elastomeric-polyurethane-scaffolds-incorporating-small-intestinal-submucosa-for-soft-tissue-engineering
#1
Lincui Da, Mei Gong, Anjing Chen, Yi Zhang, Yizhou Huang, Zhijun Guo, Shengfu Li, Jesse Li-Ling, Li Zhang, Huiqi Xie
Although soft tissue replacement has been clinically successful in many cases, the corresponding procedure has many limitations including the lack of resilience and mechanical integrity, significant donor-site morbidity, volume loss with time, and fibrous capsular contracture. These disadvantages can be alleviated by utilizing bio-absorbable scaffolds with high resilience and large strain, which are capable of stimulating natural tissue regeneration. Hence, the chemically crosslinked tridimensional scaffolds obtained by incorporating water-based polyurethane (PU) (which was synthesized from polytetramethylene ether glycol, isophorone diisocyanate, and 2,2-bis(hydroxymethyl) butyric acid) into a bioactive extracellular matrix consisting of small intestinal submucosa (SIS) have been tested in this study to develop a new approach for soft tissue engineering...
May 17, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28527469/molecular-adsorption-at-electrolyte-%C3%AE-al2o3-interface-of-aluminum-electrolytic-capacitor-revealed-by-sum-frequency-vibrational-spectroscopy
#2
Ming Jia, Xiaoyu Hu, Jin Liu, Yexiang Liu, Liang Ai
The operating voltage of an aluminum electrolytic capacitor is determined by the breakdown voltage (Ub) of the Al2O3 anode. Ub is related to the molecular adsorption at the Al2O3/electrolyte interface. Therefore, we have employed sum-frequency vibrational spectroscopy (SFVS) to study the adsorption states of a simple electrolyte, ethylene glycol (EG) solution with ammonium adipate, on an α-Al2O3 surface. In an acidic electrolyte (pH < 6), the Al2O3 surface is positively charged. The observed SFVS spectra show that long chain molecules poly ethylene glycol and ethylene glycol adipate adopt a "lying" orientation at the interface...
May 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28527016/chemical-derivatization-of-metabolite-mass-profiling-of-the-recretohalophyte-aeluropus-lagopoides-revealing-salt-stress-tolerance-mechanism
#3
Murali Krishna Paidi, Parinita Agarwal, Prashant More, Pradeep K Agarwal
Plants are the primary producers of food for human being. Their intracellular environment alternation is influenced by abiotic stress factors such as drought, heat and soil salinity. Aeluropus lagopoides is a strong halophyte that grows with ease under high saline muddy banks of creeks of Gujarat, India. To study the response of salinity on metabolite changes in Aeluropus, three treatments, i.e. control, salinity and recovery, were selected for both shoot and root tissue. The cytosolic metabolite state was analysed by molecular chemical derivatization gas chromatography mass profiling...
May 19, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28525957/determining-dominant-driving-forces-affecting-controlled-protein-release-from-polymeric-nanoparticles
#4
Josh Smith, Kayla G Sprenger, Rick Liao, Andrea Joseph, Elizabeth Nance, Jim Pfaendtner
Enzymes play a critical role in many applications in biology and medicine as potential therapeutics. One specific area of interest is enzyme encapsulation in polymer nanostructures, which have applications in drug delivery and catalysis. A detailed understanding of the mechanisms governing protein/polymer interactions is crucial for optimizing the performance of these complex systems for different applications. Using a combined computational and experimental approach, this study aims to quantify the relative importance of molecular and mesoscale driving forces to protein release from polymeric nanoparticles...
May 19, 2017: Biointerphases
https://www.readbyqxmd.com/read/28525949/capsaicin-loaded-folic-acid-conjugated-lipid-nanoparticles-for-enhanced-therapeutic-efficacy-in-ovarian-cancers
#5
Lin Lv, Yu-Xin Zhuang, Hui-Wu Zhang, Nan-Nan Tian, Wen-Zhen Dang, Shao-Yu Wu
In this study, folic acid-conjugated lipid nanoparticles were successfully prepared to enhance the active targeting of capsaicin (CAP) in ovarian cancers. The particles were nanosized and exhibited a controlled release of drug in the physiological conditions. The folic acid (FA)-conjugated system exhibited a remarkably higher uptake of nanoparticles in the cancer cells compared to that of non-targeted system. The folate-conjugated CAP-loaded lipid nanoparticles (CFLN) upon interacting with cancer cells were internalized via receptor-mediated endocytosis mechanism and resulted in higher concentration in the cancer cells...
May 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28524376/fluorinated-peg-polypeptide-polyplex-micelles-have-good-serum-resistance-and-low-cytotoxicity-for-gene-delivery
#6
Ting Wu, Longhai Wang, Shenggang Ding, Yezi You
A novel PEGylation polypeptide, poly(ethylene glycol)-b-poly(l-lysine)-b-poly(l-cysteine) (PEG-PLL-PCys) triblock copolymer is synthesized via the sequential ring-opening polymerization of amino acid N-carboxyanhydrides initiated by methoxypolyethylene glycol amine (mPEG-NH2 , Mw is 2 kDa). Subsequently, the obtained polypeptide is partially conjugated with fluorocarbon chains via disulfide exchange reaction. PLL segment can condense plasmid DNA through an electrostatic force to form a complex core, PEG segment surrounding the complex like a corona can prevent the complex from precipitation and reduce the adsorption of serum, while PCys segment with fluorocarbon can enhance the cellular uptake and the stability of the formed polyplex micelles in physiological conditions...
May 19, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28522396/ultrafast-spectroscopy-on-dna-cleavage-by-endonuclease-in-molecular-crowding
#7
Priya Singh, Susobhan Choudhury, Shreyasi Dutta, Aniruddha Adhikari, Siddhartha Bhattacharya, Debasish Pal, Samir Kumar Pal
The jam-packed intracellular environments differ the activity of a biological macromolecule from that in laboratory environments (in vitro) through a number of mechanisms called molecular crowding related to structure, function and dynamics of the macromolecule. Here, we have explored the structure, function and dynamics of a model enzyme protein DNase I in molecular crowing of polyethylene glycol (PEG; MW 3350). We have used steady state and picosecond resolved dynamics of a well-known intercalator ethidium bromide (EB) in a 20-mer double-stranded DNA (dsDNA) to monitor the DNA-cleavage by the enzyme in absence and presence PEG...
May 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28521697/an-accelerated-release-method-of-risperidone-loaded-plga-microspheres-with-good-ivivc
#8
Hu Xiaoqin, Jianwei Zhang, Xuemei Tang, Mingyuan Li, Siyu Ma, Cheng Liu, Gao Yue, Yue Zhang, Yan Liu, Fanglin Yu, Yang Yang, Guo Jia, Zhiping Li, Xingguo Mei
The purpose of this study was to obtain an accelerated release method of risperidone loaded poly(lactic-co-glycolic acid) (PLGA) microspheres with good in vitro/in vivo correlation (IVIVC). Two formulations of risperidone loaded PLGA microspheres used for evaluating IVIVC were prepared by O/W method. The accelerated release condition was optimized by investigating the effect of pH, osmotic pressure, temperature and ethanol concentration on the release of risperidone from microspheres and the in vitro accelerated release profiles of risperidone from PLGA microspheres were obtained under this optimized accelerated release condition...
May 15, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28521677/molluscum-contagiosum-an-update
#9
Alexander Kc Leung, Benjamin Barankin, Kam Lun Hon
BACKGROUND: Molluscum contagiosum is a viral cutaneous infection in childhood that occurs worldwide. Physicians should familiarize themselves with this common condition. OBJECTIVE: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications and, in particular, treatment of molluscum contagiosum. METHODS: A PubMed search was completed in Clinical Queries using the key term "molluscum contagiosum". Patents were searched using the key term "molluscum contagiosum" from www...
May 17, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28520445/telodendrimers-for-physical-encapsulation-and-covalent-linking-of-individual-or-combined-therapeutics
#10
Ashok Kakkar, Jason Choi, Alexandre Moquin, Enzo Bomal, Li Na, Dusica Maysinger
New therapeutics for glioblastoma multiforme and our ability to deliver them using efficient nanocarriers, constitute topical areas of research. We report a comparative study of temozolomide and quercetin in the treatment of glioblastoma (GBM) in 3D, and their incorporation into micelles obtained from synthetically articulated architectural copolymers, and a commercially available linear polymer poly(ethylene glycol)-poly(lactic-co-glycolic acid) (PEG-PLGA). A versatile synthetic methodology to telodendrimers which can be easily adapted to the needs of other therapeutic interventions, is presented...
May 18, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28517011/dissection-of-h-bonding-interactions-in-a-glycolic-acid-water-dimer
#11
Quanli Gu, Dan Shen, Zhen Tang, Wei Wu, Peifeng Su, Yong Xia, Zhijun Yang, Carl O Trindle
The binding strength and collective effects of multiple H-bonds in the glycolic acid-water dimer were studied in comparison to the aromatic analog, 9-hydroxy-9-fluorene carboxylic acid (9HFCA). Quantitative analysis by the generalized Kohn-Sham energy decomposition analysis shows that the energy difference in each specific physical interaction, from a glycolic acid-water dimer to a 9HFCA-water dimer, is small and amounts to less than 5% of the binding energy of the 9HFCA-water dimer. Extensive comparison of further, similar H-bonded complexes with widely varying binding strengths reinforces their excellent analogy in that the fluorene group acts as a non-interfering spectator for intermolecular H-bonding interactions...
May 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28516460/taxane-grafted-metal-oxide-nanoparticles-as-a-new-theranostic-tool-against-cancer-the-promising-example-of-docetaxel-functionalized-titanate-nanotubes-on-prostate-tumors
#12
Alexis Loiseau, Julien Boudon, Céline Mirjolet, Gilles Créhange, Nadine Millot
The combination of anticancer drugs and metal oxide nanoparticles is of great interest in cancer nanomedicine. Here, the development of a new nanohybrid, titanate nanotube-docetaxel (TiONts-DTX) is reported, the two parts of which are conjugated by covalent linkages. Unlike most nanoparticles currently being developed for biomedical purposes, TiONts present a needle-shaped morphology. The surface of TiONts is linked with 3-aminopropyl triethoxysilane and with a hetero-bifunctional polymer (polyethylene glycol) to create well-dispersed and biocompatible nanovectors...
May 18, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28516417/microbial-lipid-production-from-enzymatic-hydrolysate-of-pecan-nutshell-pretreated-by-combined-pretreatment
#13
Lizhen Qin, Hanyu Qian, Yucai He
Biodiesel is a fuel composed of monoalkyl esters of long-chain fatty acids derived from renewable biomass sources. In this study, biomass waste pecan nutshell (PS) was attempted to be converted into microbial oil. For effective utilization of PS, sequential pretreatment with ethylene glycol-H2SO4-water (78:2:20, wt:wt:wt) at 130 °C for 30 min and aqueous ammonia (25 wt%) at 50 °C for 24 h was used to enhance its enzymatic saccharification. Significant linear correlation was obtained about delignification-saccharification (R (2) = 0...
May 17, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28516412/optimization-of-adhesive-pastes-for-dental-caries-prevention
#14
Patteera Sodata, Apa Juntavee, Niwut Juntavee, Jomjai Peerapattana
Dental caries prevention products available on the market contain only remineralizing agents or antibacterial agents. This study aimed to develop adhesive pastes containing calcium phosphate and α-mangostin for dental caries prevention using the optimization technique. Calcium phosphate was used as a remineralizing agent, and extracted α-mangostin was used as an antibacterial agent. The effect of the independent variables, which were fumed silica, Eudragit(®) EPO, polyethylene glycol, and ethyl alcohol, on the responses was investigated...
May 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28516168/selective-surface-pegylation-of-uio-66-nanoparticles-for-enhanced-stability-cell-uptake-and-ph-responsive-drug-delivery
#15
Isabel Abánades Lázaro, Salame Haddad, Sabrina Sacca, Claudia Orellana-Tavra, David Fairen-Jimenez, Ross S Forgan
The high storage capacities and excellent biocompatibilities of metal-organic frameworks (MOFs) have made them emerging candidates as drug-delivery vectors. Incorporation of surface functionality is a route to enhanced properties, and here we report on a surface-modification procedure-click modulation-that controls their size and surface chemistry. The zirconium terephthalate MOF UiO-66 is (1) synthesized as ∼200 nm nanoparticles coated with functionalized modulators, (2) loaded with cargo, and (3) covalently surface modified with poly(ethylene glycol) (PEG) chains through mild bioconjugate reactions...
April 13, 2017: Chem
https://www.readbyqxmd.com/read/28515763/poly-ethylene-co-vinyl-alcohol-based-polymeric-thermo-responsive-nanocarriers-for-controlled-delivery-of-epirubicin-to-hepatocellular-carcinoma
#16
Farshid Hassanzadeh, Maryam Farzan, Jaleh Varshosaz, Ghadam Ali Khodarahmi, Sahar Maaleki, Mahboubeh Rostami
In this study, poly(ethylene-co-vinyl alcohol) (EVOH) as a novel biocompatible polymeric scaffold was surface modified by succinylation to get EVOHS and further pegylated to improve structural properties using methoxypolyethylene glycol (5000 Da) succinate (PEGS) along with targeting with retinoic acid (RA) to get final modified active and passive targeted conjugate (PEGS-EVOHS-RA) to evaluate its ability in carrying and delivery of epirubicin to hepatocellular carcinoma cell lines in response to varying temperatures...
April 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28514061/mapping-intermediate-degradation-products-of-poly-lactic-co-glycolic-acid-in-vitro
#17
Jian Li, Peter Nemes, Ji Guo
There is widespread interest in using absorbable polymers, such as poly(lactic-co-glycolic acid) (PLGA), as components in the design and manufacture of new-generation drug eluting stents (DES). PLGA undergoes hydrolysis to progressively degrade through intermediate chemical entities to simple organic acids that are ultimately absorbed by the human body. Understanding the composition and structure of these intermediate degradation products is critical not only to elucidate polymer degradation pathways accurately, but also to assess the safety and performance of absorbable cardiovascular implants...
May 17, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28513723/amphiphilic-coatings-for-the-protection-of-upconverting-nanoparticles-against-dissolution-in-aqueous-media
#18
Olivija Plohl, Slavko Kralj, Boris Majaron, Eleonore Fröhlich, Maja Ponikvar-Svet, Darko Makovec, Darja Lisjak
Upconverting nanoparticles (UCNPs) of β-NaYF4, co-doped with Yb(3+) and Tm(3+) and 21-36 nm large, were synthesized using a modified thermal decomposition method. The as-synthesized UCNPs were coated with oleic acid and dispersed in nonpolar media. Their morphology, size and crystal structure were analysed with transmission electron microscopy and X-ray diffraction. The UCNPs showed a fluorescence emission spectrum characteristic of Tm(3+). Their dissolution in water (pH ∼ 4-5) and phosphate buffered saline (PBS, pH = 7...
May 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28511928/rational-design-of-nanoparticles-towards-targeting-antigen-presenting-cells-and-improved-t-cell-priming
#19
Eva Zupančič, Caterina Curato, Maria Paisana, Catarina Rodrigues, Ziv Porat, Ana S Viana, Carlos A M Afonso, João Pinto, Rogério Gaspar, João N Moreira, Ronit Satchi-Fainaro, Steffen Jung, Helena F Florindo
Vaccination is a promising strategy to trigger and boost immune responses against cancer or infectious disease. We have designed, synthesized and characterized aliphatic-polyester (poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP) to investigate how the nature of protein association (adsorbed versus entrapped) and polymer/surfactant concentrations impact on the generation and modulation of antigen-specific immune responses. The ability of the NP formulations to target dendritic cells (DC), be internalized and activate the T cells was characterized and optimized in vitro and in vivo using markers of DC activation and co-stimulatory molecules...
May 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28511059/development-and-validation-of-a-rapid-reversed-phase-hplc-method-for-the-quantification-of-monoclonal-antibody-bevacizumab-from-polyester-based-nanoparticles
#20
Flávia Sousa, Virgínia M F Gonçalves, Bruno Sarmento
Bevacizumab is a powerful human monoclonal antibody approved worldwide for treatment of several types of cancer and ocular diseases due to its potential as antiangiogenic drug. Nowadays, in order to improve the monoclonal antibody-based therapy, attempts have been focused in the formulation of these biomacromolecules into nanoparticles. Thus, the aim of this work was to develop and validate a reversed-phase high-performance liquid chromatography with fluorescence detection method for the determination of bevacizumab from nanoparticulate systems, according to the International Conference on Harmonization guidelines...
May 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
keyword
keyword
36380
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"