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https://www.readbyqxmd.com/read/29924221/tazarotene-gel-with-narrow-band-uvb-phototherapy-a-synergistic-combination-in-psoriasis
#1
Surabhi Dayal, Rajiv Kaura, Priyadarshini Sahu, Vijay Kumar Jain
BACKGROUND: Narrow-band UVB (NB-UVB) has been shown to be one of the most effective treatment modalities for psoriasis. Tazarotene, a known effective anti-psoriatic modality, when combined with NB-UVB may enhance the therapeutic success. OBJECTIVE: To study clinical efficacy and safety of combination of NB-UVB with topical tazarotene 0.05% gel in psoriasis. METHOD: Thirty patients with plaque psoriasis having symmetrical lesions were enrolled for 12 weeks...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29902837/tazarotene-induced-gene-1-interacts-with-dnajc8-and-regulates-glycolysis-in-cervical-cancer-cells
#2
Chun-Hua Wang, Rong-Yaun Shyu, Chang-Chieh Wu, Mao-Liang Chen, Ming-Cheng Lee, Yi-Yin Lin, Lu-Kai Wang, Shun-Yuan Jiang, Fu-Ming Tsai
The tazarotene-induced gene 1 (TIG1) protein is a retinoidinducible growth regulator and is considered a tumor suppressor. Here, we show that DnaJ heat shock protein family member C8 (DNAJC8) is a TIG1 target that regulates glycolysis. Ectopic DNAJC8 expression induced the translocation of pyruvate kinase M2 (PKM2) into the nucleus, subsequently inducing glucose transporter 1 (GLUT1) expression to promote glucose uptake. Silencing either DNAJC8 or PKM2 alleviated the upregulation of GLUT1 expression and glucose uptake induced by ectopic DNAJC8 expression...
June 14, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29847610/rate-of-recurrence-of-lentigo-maligna-treated-with-off-label-neoadjuvant-topical-imiquimod-5-cream-prior-to-conservatively-staged-excision
#3
Jessica M Donigan, Mark A Hyde, David E Goldgar, Michael L Hadley, Marianne Bowling, Glen M Bowen
Importance: Staged excision of lentigo maligna (LM) often requires multiple stages and can result in significant cosmetic morbidity. Imiquimod cream has been used off-label as monotherapy in the treatment of LM and may be used in the neoadjuvant setting prior to staged excision as a strategy to reduce the size of the surgical margins required to confirm negative histologic margins. Objective: To examine the rate of recurrence of LM in patients treated with neoadjuvant topical imiquimod, 5%, cream prior to conservatively staged excisions...
May 30, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29614243/safety-and-efficacy-of-a-halobetasol-tazarotene-fixed-combination-in-the-treatment-of-moderate-to-severe-plaque-psoriasis-results-of-two-phase-3-randomized-controlled-trials
#4
Linda Stein Gold, Mark G Lebwohl, Jeffrey L Sugarman, David M Pariser, Tina Lin, Gina Martin, Radhakrishnan Pillai, Robert Israel, Tage Ramakrishna
Topical corticosteroids are the mainstay of psoriasis treatment; long-term safety concerns limit use. Combination with tazarotene may optimize efficacy, minimizing safety/tolerability concerns, In patients with moderate-to-severe plaque psoriasis treated with HP/TAZ lotion, improvement is noted within 2 weeks with few adverse effects observed after 8 weeks., HP/TAZ lotion may provide a realistic topical option for psoriasis management.
March 31, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29421320/retinoic-acid-receptor-%C3%AE-a-potential-therapeutic-target-in-the-inhibition-of-adenovirus-replication
#5
Xiaolong Wang, Qiling Zhang, Zhe Zhou, Manjiao Liu, Yubao Chen, Jianbo Li, Linlin Xu, Jing Guo, Qingjun Li, Jing Yang, Shengqi Wang
Human adenoviruses (HAdVs) usually cause mild respiratory infections, but they can also lead to fatal outcomes for immunosuppressive patients. Unfortunately, there has been no specific anti-HAdV drug approved for medical use. A better understanding of the nature of virus-host interactions during infection is beneficial to the discovery of potential antiviral targets and new antiviral drugs. In this study, a time-course transcriptome analysis of HAdV-infected human lung epithelial cells (A549 cells) was performed to investigate virus-host interactions, and several key host molecules involved in the HAdV infection process were identified...
April 2018: Antiviral Research
https://www.readbyqxmd.com/read/29169400/hypermethylation-and-loss-of-retinoic-acid-receptor-responder-1-expression-in-human-choriocarcinoma
#6
H Huebner, R Strick, D L Wachter, S Kehl, P L Strissel, R Schneider-Stock, A Hartner, W Rascher, L C Horn, M W Beckmann, M Ruebner, F B Fahlbusch
BACKGROUND: Human placental development resembles tumorigenesis, due to the invasive and fusogenic potential of trophoblasts. However, these features are tightly controlled in trophoblasts. Disturbance of this spatial and temporal regulation is thought to contribute to the rare formation of choriocarcinomas. Promoter hypermethylation and loss of the tumor suppressor Retinoic acid receptor responder 1 (RARRES1) were shown to contribute to cancer progression. Our study investigated the epigenetic and transcriptional regulation of RARRES1 in healthy human placenta in comparison to choriocarcinoma cell lines and cases...
November 23, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28913735/efficacy-and-safety-of-tazarotene-0-1-plus-clindamycin-1-gel-versus-adapalene-0-1-plus-clindamycin-1-gel-in-facial-acne-vulgaris-a-randomized-controlled-clinical-trial
#7
RANDOMIZED CONTROLLED TRIAL
Rituparna Maiti, Chandra Sekhar Sirka, M A Ashique Rahman, Anand Srinivasan, Sansita Parida, Debasish Hota
BACKGROUND: Acne vulgaris is a multifactorial disorder which is ideally treated with combination therapy with topical retinoids and antibiotics. OBJECTIVES: The present study was conducted to compare the efficacy and safety of tazarotene plus clindamycin against adapalene plus clindamycin in facial acne vulgaris. METHODS: This study is a randomized, open-label, parallel design clinical trial conducted on 60 patients with facial acne at the outpatient dermatology department in a tertiary healthcare center...
November 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28912874/dietary-vitamin-b6-modulates-the-gene-expression-of-myokines-nrf2-related-factors-myogenin-and-hsp60-in-the-skeletal-muscle-of-rats
#8
Sofya Suidasari, Shinji Uragami, Noriyuki Yanaka, Norihisa Kato
Previous studies have suggested that vitamin B6 is an ergogenic factor. However, the role of dietary vitamin B6 in skeletal muscle has not been widely researched. The aim of the present study was to investigate the effects of dietary vitamin B6 on the gene expression of 19 myokines, 14 nuclear factor erythroid 2-related factor 2 (Nrf2)-regulated factors, 8 myogenesis-related factors and 4 heat shock proteins (HSPs), which may serve important roles in skeletal muscles. Rats were fed a diet containing 1 (marginal vitamin B6 deficiency), 7 (recommended dietary level) or 35 mg/kg of pyridoxine (PN) HCl/ for 6 weeks...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28895378/complete-regression-of-keratoacanthoma-with-topical-tazarotene-gel-0-1-therapeutic-and-pathophysiological-perspectives
#9
Giovanni Paolino, Luca M Muscardin, Michele Donati, Dario Didona, Chiara Panetta, Pietro Donati
No abstract text is available yet for this article.
September 8, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28885351/a-mal-de-meleda-patient-with-severe-flexion-contractures-of-hands-and-feet-a-case-report-in-west-china
#10
Yun Pan, Hengguang Zhao, Aijun Chen, Xin Huang
RATIONALE: Palmoplantar keratoderma (PPK) is a genetically heterogeneous group of skin diseases, which is characterized by erythema and hyperkeratosis. Mal de Meleda (MDM) is a rare type of PPK with an estimated prevalence in the general population of 1 in 100,000. PATIENT CONCERNS: In this study, we report a MDM patient with severe lesion in skin and flexion contractures of fingers and toes. DIAGNOSES: MDM was diagnosed based on clinical manifestations and gene test...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28815772/ectropion-improvement-with-topical-tazarotene-in-children-with-lamellar-ichthyosis
#11
Brooke Hanson, Lauren Becker, Kristen Hook, Ingrid Polcari, Raymond G Areaux, Sheilagh Maguiness
BACKGROUND/OBJECTIVES: Lamellar ichthyosis (LI) is a well-described phenotypic subtype of autosomal recessive congenital ichthyosis (ARCI). The condition typically presents at birth with collodion membrane and leads to thick, plate-like scaling of the skin throughout the body, alopecia, and prominent ocular manifestations. Ocular complications include bilateral cicatricial ectropion and lagophthalmos. These ocular complications can lead to chronic exposure keratitis and in some cases corneal ulceration and blindness...
August 17, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28761838/topical-therapies-in-psoriasis
#12
REVIEW
R Torsekar, Manjyot M Gautam
Topical therapy as monotherapy is useful in psoriasis patients with mild disease. Topical agents are also used as adjuvant for moderate-to-severe disease who are being concurrently treated with either ultraviolet light or systemic medications. Emollients are useful adjuncts to the treatment of psoriasis. Use of older topical agents such as anthralin and coal tar has declined over the years. However, they are cheaper and can still be used for the treatment of difficult psoriasis refractory to conventional treatment...
July 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28678839/multiple-roles-of-rarres1-in-prostate-cancer-autophagy-induction-and-angiogenesis-inhibition
#13
Arpita Roy, Malathi Ramalinga, Okjin J Kim, Juliet Chijioke, Solomon Lynch, Stephen Byers, Deepak Kumar
BACKGROUND: Prostate cancer (PCa) poses a major health concern in men worldwide. Retinoic Acid Receptor Responder (RARRES1)/ Tazarotene-induced gene-1 (TIG-1) is a putative tumor suppressor gene that exerts its tumor suppressor function via unknown mechanisms. Epigenetic silencing of RARRES1 leads to its loss in several types of cancer, including PCa. Determining the molecular mechanisms that mediate the tumor suppressor role of RARRES1 in PCa is the focus of our study. FINDINGS: Our data indicates that RARRES1 over expression in PCa cell lines represses mitogen-activated protein kinase (MAPK) activation...
2017: PloS One
https://www.readbyqxmd.com/read/28639915/high-expression-of-tig3-predicts-poor-survival-in-patients-with-primary-glioblastoma
#14
Hongxiang Wang, Hanchong Xu, Tao Xu, Cong Tan, Mei Jiang, Yihong Chen, Xinyu Hu, Jinxu Zhou, Junyan Shen, Rong Qin, Daiyu Hu, Qilin Huang, Min Wang, Lian Wang, Dongxia Duan, Yong Yan, Juxiang Chen
TIG3 (tazarotene-induced gene 3) has been reported to suppress the progression of several malignancies, where this gene is universally downregulated. However, the expression of TIG3 in primary glioblastoma and its relevance to patient's prognosis have not been elaborated. Thus, this study was aimed to evaluate TIG3 expression level in primary glioblastoma and investigate the prognostic value of TIG3 for patients. The Cancer Genome Atlas database was first utilized to analyze the expression and prognostic potential of TIG3 in 528 glioblastoma cases...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28629004/performance-evaluation-of-non-ionic-surfactant-based-tazarotene-encapsulated-proniosomal-gel-for-the-treatment-of-psoriasis
#15
Vure Prasad, Sundeep Chaurasia
The study aims to explore the potential of non-ionic surfactant based proniosomal gel (PNG) in improving the topical delivery of tazarotene by in vitro and in vivo studies. The PNG was prepared using coacervation phase separation method composed of span, stearylamine, cholesterol, and lecithin. The PNG demonstrated favorable vesicle size (3.26±0.22μm) and percent encapsulation efficiency (49.50±2.3%). The PNG was evaluated for viscosity which indicated that the ratio of span:cholesterol:stearylamine (64...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28543445/psoriasis-in-those-planning-a-family-pregnant-or-breast-feeding-the-australasian-psoriasis-collaboration
#16
REVIEW
Marius Rademaker, Karen Agnew, Megan Andrews, Katherine Armour, Chris Baker, Peter Foley, John Frew, Kurt Gebauer, Monisha Gupta, Debra Kennedy, Gillian Marshman, John Sullivan
The Australasian Psoriasis Collaboration has reviewed the evidence for managing moderate to severe psoriasis in those who are pregnant or are breast-feeding, or planning a family. The severity of the psoriasis, associated comorbidities and specific anti-psoriasis treatment, along with other exposures, can have a deleterious effect on pregnancy outcomes. Psoriasis itself increases the risk of preterm and low birthweight babies, along with spontaneous and induced abortions, but no specific birth defects have been otherwise demonstrated...
May 23, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28301614/a-phase-2-multicenter-double-blind-randomized-vehicle-controlled-clinical-study-to-assess-the-safety-and-efficacy-of-a-halobetasol-tazarotene-fixed-combination-in-the-treatment-of-plaque-psoriasis
#17
RANDOMIZED CONTROLLED TRIAL
Jeffrey L Sugarman, Linda Stein Gold, Mark G Lebwohl, David M Pariser, Binu J Alexander, Radhakrishnan Pillai
<p>BACKGROUND: Psoriasis is a chronic, immune-mediated disease that varies widely in its clinical expression. Treatment options focus on relieving symptoms, reducing inflammation, induration, and scaling, and controlling the extent of the disease. Topical corticosteroids are the mainstay of treatment, however long-term safety remains a concern, particularly with the more potent formulations. Combination therapy with a corticosteroid and tazarotene may improve psoriasis signs at a lower corticosteroid concentration providing a superior safety profile...
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28247492/lentigo-maligna-successfully-treated-with-combination-therapy-of-topical-tazarotene-and-imiquimod
#18
S Menzies, M Mc Menamin, R Barry
No abstract text is available yet for this article.
March 1, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28052368/synthesis-and-activity-of-the-salicylic-acid-ester-of-bakuchiol-in-psoriasis-surrogate-keratinocytes-and-skin-substitutes
#19
S Ma, K Gobis, W R Swindell, R Chaudhuri, R Bojanowski, K Bojanowski
BACKGROUND: Topical retinoids are effective in retarding skin ageing and restoring homeostasis in skin conditions such as psoriasis. However their adverse effects (AEs), which include irritation (retinoid dermatitis), photosensitivity and teratogenicity, limit their use and patient compliance. Development of retinoid analogues with minimal AEs would allow a broader and more compliant use. AIM: To synthesise a novel molecule, bakuchiol salicylate (bakusylan), with a modulatory gene expression profile similar to retinoids, using as reference three prescription retinoids: tretinoin, tazarotene and adapalene...
April 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27989102/tazarotene-induced-gene-1-enhanced-cervical-cell-autophagy-through-transmembrane-protein-192
#20
Rong-Yaun Shyu, Chun-Hua Wang, Chang-Chieh Wu, Mao-Liang Chen, Ming-Cheng Lee, Lu-Kai Wang, Shun-Yuan Jiang, Fu-Ming Tsai
Tazarotene-induced gene 1 (TIG1) is a retinoic acid-inducible protein that is considered a putative tumor suppressor. The expression of TIG1 is decreased in malignant prostate carcinoma or poorly differentiated colorectal adenocarcinoma, but TIG1 is present in benign or well-differentiated tumors. Ectopic TIG1 expression led to suppression of growth in cancer cells. However, the function of TIG1 in cell differentiation is still unknown. Using a yeast two-hybrid system, we found that transmembrane protein 192 (TMEM192) interacted with TIG1...
December 2016: Molecules and Cells
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