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https://www.readbyqxmd.com/read/27698842/tazarotene-induced-gene-2-is-associated-with-poor-survival-in-non-small-cell-lung-cancer
#1
Qi Cai, Zhongwei Huang, Lei Qi, Ting Wang, Yanbo Shen, Jian'an Huang
The aim of the present study was to investigate the expression of tazarotene-induced gene 2 (TIG2) and evaluate the clinicopathological variables and prognostic value for non-small cell lung cancer (NSCLC) patients. Reverse transcription-polymerase chain reaction and western blotting were utilized to detect TIG2 expression in NSCLC specimens and adjacent noncancerous tissue. Furthermore, the present study investigated the protein expression and the clinicopathological significance of TIG2 in 98 paraffin-embedded NSCLC samples by using immunohistochemistry...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27627552/the-negative-impact-of-selective-activation-of-retinoic-acid-receptors-on-bone-metabolism-and-bone-mechanical-properties-in-rats
#2
Beata Nowak, Agnieszka Matuszewska, Jarosław Filipiak, Anna Nikodem, Anna Merwid-Ląd, Małgorzata Pieśniewska, Joanna Kwiatkowska, Bartosz Grotthus, Adam Szeląg
BACKGROUND: Drug-induced osteoporosis is a significant health problem, as many drugs have deleterious effects on bone metabolism. Data from several studies concerning the influence of retinol on bone homeostasis are inconsistent. OBJECTIVES: The purpose of this study was to investigate the influence of tazarotene, a selective agonist of the retinoic acid receptor (RAR), on bone metabolism and bone mechanical properties in rats. MATERIAL AND METHODS: Sixteen male Wistar rats were assigned either to the group receiving tazarotene or to the control group...
March 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27435415/health-economic-analyses-of-psoriasis-management-a-systematic-literature-search
#3
Mandy Gutknecht, Magdalene Krensel, Matthias Augustin
In the course of the chronic skin disease psoriasis, where a variety of treatment interventions is available, a strong growth of health economic studies comparing treatment costs and benefits can be noticed. The objective was to identify health economic evaluations of psoriasis treatments that have been published to date. Of particular interest were the mostly used analysis and outcome parameters, the compared treatments, and the question, if available health economic studies may be used to perform a meta-analysis of qualitative findings...
November 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27424662/comparison-of-the-ligand-binding-site-of-cyp2c8-with-cyp26a1-and-cyp26b1-a-structural-basis-for-the-identification-of-new-inhibitors-of-the-retinoic-acid-hydroxylases
#4
Robert S Foti, Philippe Diaz, Dominique Douguet
The CYP26s are responsible for metabolizing retinoic acid and play an important role in maintaining homeostatic levels of retinoic acid. Given the ability of CYP2C8 to metabolize retinoic acid, we evaluated the potential for CYP2C8 inhibitors to also inhibit CYP26. In vitro assays were used to evaluate the inhibition potencies of CYP2C8 inhibitors against CYP26A1 and CYP26B1. Using tazarotenic acid as a substrate for CYP26, IC50 values for 17 inhibitors of CYP2C8 were determined for CYP26A1 and CYP26B1, ranging from ∼20 nM to 100 μM, with a positive correlation observed between IC50s for CYP2C8 and CYP26A1...
July 17, 2016: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/27220773/how-much-do-we-know-about-maintaining-treatment-response-after-successful-acne-therapy-systematic-review-on-the-efficacy-and-safety-of-acne-maintenance-therapy
#5
Corinna Dressler, Stefanie Rosumeck, Alexander Nast
After cessation of successful initial acne therapy, patients often experience flares. Consecutive maintenance treatment after successful induction therapy is promoted by guidelines; however, little is known about the efficacy/safety of different maintenance regimens. A systematic review on acne maintenance treatments was conducted. We identified 5 randomized controlled trials [RCTs; adapalene vs. vehicle or vs. no treatment (3 RCTs), adapalene/benzoyl peroxide (BPO) vs. vehicle, combination/monotherapy of minocycline (systemic)/tazarotene/placebo] and 3 non-RCTs on systemic isotretinoin, adapalene/BPO and azelaic acid...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27174314/jojoba-oil-soft-colloidal-nanocarrier-of-a-synthetic-retinoid-preparation-characterization-and-clinical-efficacy-in-psoriatic-patients
#6
Maha Nasr, Sameh Abdel-Hamid, Noha H Moftah, Maha Fadel, Abdullah A Alyoussef
BACKGROUND: Nanotechnology has provided substantial benefits in drug delivery, especially in the treatment of dermatological diseases. Psoriasis is a chronic inflammatory skin disease in which topical delivery of antipsoriatic agents is considered the first line treatment. OBJECTIVE: To investigate whether the encapsulation of the synthetic retinoid tazarotene in a nanocarrier based on jojoba oil would decrease its irritation potential and clinically improve its therapeutic outcome in psoriatic patients...
May 13, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27074696/topical-therapies-for-psoriasis-improving-management-strategies-and-patient-adherence
#7
REVIEW
Linda F Stein Gold
Psoriasis is a chronic disease that has a substantial effect on quality of life of patients and often needs long-term treatment. Topical treatments for psoriasis include corticosteroids, vitamin D derivatives, tazarotene, anthralin, tacrolimus, pimecrolimus, and newer formulations of tar. Although many of these treatments are effective, they must be prescribed appropriately and used consistently for a period of weeks to months before clinical evidence of improvement can be seen and patients perceive that the treatment is working...
March 2016: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27041288/nail-psoriasis-a-review-of-treatment-options
#8
REVIEW
Marcel C Pasch
Nail involvement affects 80-90 % of patients with plaque psoriasis, and is even more prevalent in patients with psoriatic arthritis. This review is the result of a systemic approach to the literature and covers topical, intralesional, conventional systemic, and biologic systemic treatments, as well as non-pharmacological treatment options for nail psoriasis. The available evidence suggests that all anti-tumor necrosis factor-α, anti-interleukin (IL)-17, and anti-IL-12/23 antibodies which are available for plaque psoriasis and psoriatic arthritis are highly effective treatments for nail psoriasis...
April 2016: Drugs
https://www.readbyqxmd.com/read/26955129/median-nail-dystrophy-involving-the-thumb-nail
#9
Rahulkrishna Kota, Abhishek Pilani, Pragya Ashok Nair
Median canaliform dystrophy of Heller is a rare entity characterized by a midline or a paramedian ridge or split and canal formation in nail plate of one or both the thumb nails. It is an acquired condition resulting from a temporary defect in the matrix that interferes with nail formation. Habitual picking of the nail base may be responsible for some cases. Histopathology classically shows parakeratosis, accumulation of melanin within and between the nail bed keratinocytes. Treatment of median nail dystrophy includes injectable triamcinalone acetonide, topical 0...
January 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/26951515/the-antitumor-effect-of-tig3-in-liver-cancer-cells-is-involved-in-erk1-2-inhibition
#10
Yan Xu, Ting Chen, Degui Liao, Xiaoqin Wu, Yun Zhong, Shiming Liu, Hui Yang, Yuqiang Nie
Tazarotene-induced gene 3 (TIG3) was first characterized in tazarotene-treated human keratinocytes and identified as a retinoic acid responder gene, an important mediator of antitumor effects by retinoids. In this study, we aim to investigate the inhibitory effect of TIG3 on the growth of liver cancer and explore its underlying mechanism. Human hepatocellular carcinoma (HCC) Hep3B cells were transfected with plasmid GV141 carrying full-length TIG3 complementary DNA (cDNA). The effects of TIG3 on cell proliferation, apoptosis, and migration were determined in vitro...
August 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26937021/identification-of-tazarotenic-acid-as-the-first-xenobiotic-substrate-of-human-retinoic-acid-hydroxylase-cyp26a1-and-cyp26b1
#11
Robert S Foti, Nina Isoherranen, Alex Zelter, Leslie J Dickmann, Brian R Buttrick, Philippe Diaz, Dominique Douguet
Cytochrome P450 (CYP) 26A1 and 26B1 are heme-containing enzymes responsible for metabolizing all-trans retinoic acid (at-RA). No crystal structures have been solved, and therefore homology models that provide structural information are extremely valuable for the development of inhibitors of cytochrome P450 family 26 (CYP26). The objectives of this study were to use homology models of CYP26A1 and CYP26B1 to characterize substrate binding characteristics, to compare structural aspects of their active sites, and to support the role of CYP26 in the metabolism of xenobiotics...
May 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/26765142/novel-investigational-therapies-for-onychomycosis-an-update
#12
REVIEW
Aditya K Gupta, Catherine Studholme
INTRODUCTION: Onychomycosis is an infection of the nail plate that is prevalent among the ageing population. Onychomycosis is difficult to treat with low initial cure rates, high rates of relapse, and reinfection. Present treatment options include oral and topical therapies, with oral therapies yielding better results. However, there has been a greater emphasis on the development of topical antifungal therapies as they have fewer side effects and drug interactions. AREAS COVERED: This review summarizes new and reformulated drugs...
2016: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/26569440/the-influence-of-bexarotene-a-selective-agonist-of-the-retinoid-receptor-x-rxr-and-tazarotene-a-selective-agonist-of-the-retinoid-acid-receptor-rar-on-bone-metabolism-in-rats
#13
Beata Nowak, Agnieszka Matuszewska, Jarosław Filipiak, Anna Nikodem, Anna Merwid-Ląd, Małgorzata Pieśniewska, Lidia Fereniec-Gołębiewska, Joanna Kwiatkowska, Adam Szeląg
PURPOSE: The purpose of this study was to investigate the influence of selective agonists of the retinoid receptor X (RXR) and the retinoid acid receptor (RAR) on bone metabolism in rats. METHODS: Thirty six male Wistar rats were divided into three groups: receiving bexarotene, or tazarotene, or to control group. Serum biochemical markers of bone turnover (osteocalcin - OC, tartrate resistant acid phosphatase 5 - TRACP5b and osteoprotegerin - OPG) and mechanical properties of bones were analyzed...
March 2016: Advances in Medical Sciences
https://www.readbyqxmd.com/read/26560170/tazarotene-foam-0-1-for-the-treatment-of-acne
#14
Jaclyn A Smith, Swetha Narahari, Dane Hill, Steven R Feldman
INTRODUCTION: Acne is a common skin condition of the pilosebaceous units that affects the young and old, ranges from moderate to severe and can be treated with an array of options. Topical retinoids are the initial treatment for acne due to their ability to treat comedones, the starting point of acne. AREAS COVERED: Tazarotene is a topical retinoid available as a cream, gel and foam. Tazarotene 0.1% foam was FDA approved in 2012 for the treatment of acne in patients ages ≥12 and is the first foam topical retinoid on the market...
January 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/26334480/novel-microemulsion-based-gel-formulation-of-tazarotene-for-therapy-of-acne
#15
Mrunali Rashmin Patel, Rashmin Bharatbhai Patel, Jolly R Parikh, Bharat G Patel
The objective of this study was to develop and evaluate a novel microemulsion based gel formulation containing tazarotene for targeted topical therapy of acne. Psudoternary phase diagrams were constructed to obtain the concentration range of oil, surfactant, and co-surfactant for microemulsion formation. The optimized microemulsion formulation containing 0.05% tazarotene was formulated by spontaneous microemulsification method consisting of 10% Labrafac CC, mixed emulsifiers 15% Labrasol-Cremophor-RH 40 (1:1), 15% Capmul MCM, and 60% distilled water (w/w) as an external phase...
September 3, 2015: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/26133080/optimizing-the-dermal-accumulation-of-a-tazarotene-microemulsion-using-skin-deposition-modeling
#16
Maha Nasr, Sameh Abdel-Hamid
CONTEXT: It is well known that microemulsions are mainly utilized for their transdermal rather than their dermal drug delivery potential due to their low viscosity, and the presence of penetration enhancing surfactants and co-surfactants. OBJECTIVE: Applying quality by design (QbD) principles, a tazarotene microemulsion formulation for local skin delivery was optimized by creating a control space. MATERIALS AND METHODS: Critical formulation factors (CFF) were oil, surfactant/co-surfactant (SAA/CoS), and water percentages...
2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/26035235/withdrawn-interventions-for-photodamaged-skin
#17
REVIEW
Miny Samuel, Rebecca Brooke, Sally Hollis, Christopher E M Griffiths
No abstract text is available yet for this article.
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25969914/using-photodynamic-therapy-to-estimate-effectiveness-of-innovative-combined-diclofenac-and-tazaroten-therapy-of-disseminated-actinic-keratosis
#18
Beata J Osiecka, Kamil Jurczyszyn, Piotr Nockowski, Artur Lipinski, Agnieszka Sieja, Piotr Ziółkowski
Early diagnosis and therapy of precancerous lesions and malignant tumors belong to the most challenging tasks in modern medicine. Photodynamic diagnosis can help diagnose both precancerous lesions and early carcinoma. Actinic keratosis (AK) is the most common precancerous lesion of the skin. The available data show a high effectiveness of diclofenac in treating multifocal AK. We report a case of a 52-year-old woman who complained of multiple disseminated AK lesions predominantly on the lower limbs and trunk with a significant exacerbation within the last 6 months...
2015: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/25873365/psoriasis-during-pregnancy-characteristics-and-important-management-recommendations
#19
REVIEW
Melissa B Hoffman, Michael Farhangian, Steven R Feldman
The treatment of psoriasis in pregnant women can be challenging. Psoriasis generally improves during pregnancy; however, many pregnant patients still require treatment. In treating pregnant patients, the benefits of treatment and risks to the mother and the fetus must be considered. For localized psoriasis, topical corticosteroids are the treatment of choice. Other topical agents that are approved for the treatment of psoriasis, such as topical tar products and topical tazarotene, should be avoided during pregnancy because of unclear risks of teratogenicity...
June 2015: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/25857837/a-custom-tailored-model-to-investigate-skin-penetration-in-porcine-skin-and-its-comparison-with-human-skin
#20
COMPARATIVE STUDY
Michael E Herbig, Pia Houdek, Sascha Gorissen, Michaela Zorn-Kruppa, Ewa Wladykowski, Thomas Volksdorf, Stephan Grzybowski, Georgios Kolios, Christoph Willers, Henning Mallwitz, Ingrid Moll, Johanna M Brandner
Reliable models for the determination of skin penetration and permeation are important for the development of new drugs and formulations. The intention of our study was to develop a skin penetration model which (1) is viable and well supplied with nutrients during the period of the experiment (2) is mimicking human skin as far as possible, but still is independent from the problems of supply and heterogeneity, (3) can give information about the penetration into different compartments of the skin and (4) considers specific inter-individual differences in skin thickness...
September 2015: European Journal of Pharmaceutics and Biopharmaceutics
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