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https://www.readbyqxmd.com/read/28631923/influence-of-ingesting-a-flavonoid-rich-supplement-on-the-metabolome-and-concentration-of-urine-phenolics-in-overweight-obese-women
#1
David C Nieman, Sivapriya Ramamoorthy, Colin D Kay, Courtney L Goodman, Christopher R Capps, Zach L Shue, Nicole Heyl, Mary H Grace
This study evaluated the effect of ingesting a flavonoid-rich supplement (329 mg/d) on total urine phenolics and shifts in plasma metabolites in overweight/obese female adults using untargeted metabolomics procedures. Participants (N=103, 18-65 y, BMI ≥ 25 kg/m2) were randomized to flavonoid (F) or placebo (P) groups for 12 weeks, with blood and 24-h urine samples collected pre-study, 4- and 12-weeks in a parallel design. Supplements were prepared as chewable tablets, and included vitamin C, wild bilberry fruit extract, green tea leaf extract, quercetin, caffeine, and omega 3 fatty acids...
June 20, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28624857/bioaccumulation-of-heavy-metals-and-ecophysiological-responses-to-heavy-metal-stress-in-selected-populations-of-vaccinium-myrtillus-l-and-vaccinium-vitis-idaea-l
#2
Marta Kandziora-Ciupa, Aleksandra Nadgórska-Socha, Gabriela Barczyk, Ryszard Ciepał
The aim of this study was to determine the concentrations of heavy metals (Cd, Pb, Zn, Fe, and Mn) in soil, and their bioavailability and bioaccumulation in Vaccinium myrtillus L. and Vaccinium vitis-idaea L. organs. Analysis also concerned the physiological responses of these plants from three polluted sites (immediate vicinity of a zinc smelter in Miasteczko Śląskie, ArcelorMittal Poland S.A. iron smelter in Dąbrowa Górnicza-Łosień, and Jaworzno III power plant in Jaworzno) and one pseudo-control site (Pazurek nature reserve in Jaroszowiec Olkuski)...
June 17, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28617532/the-effect-of-a-natural-standardized-bilberry-extract-mirtoselect%C3%A2-in-dry-eye-a-randomized-double-blinded-placebo-controlled-trial
#3
A Riva, S Togni, F Franceschi, S Kawada, Y Inaba, R Eggenhoffner, L Giacomelli
OBJECTIVE: Dry eye, a chronic disease of lachrymal fluid and corneo-conjunctival epithelium, could significantly impact visual function, affects quality of life and work productivity. Beside several conventional treatments, nutritional supplements based on bilberry extract have been identified as effective contributors to eye health. Here, we aim at investigating the bioavailability of a standardized bilberry extract, its ability to alleviate dry eye symptoms and its antioxidant potential...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28609455/differential-iridoid-production-as-revealed-by-a-diversity-panel-of-84-cultivated-and-wild-blueberry-species
#4
Courtney P Leisner, Mohamed O Kamileen, Megan E Conway, Sarah E O'Connor, C Robin Buell
Cultivated blueberry (Vaccinium corymbosum, Vaccinium angustifolium, Vaccinium darrowii, and Vaccinium virgatum) is an economically important fruit crop native to North America and a member of the Ericaceae family. Several species in the Ericaceae family including cranberry, lignonberry, bilberry, and neotropical blueberry species have been shown to produce iridoids, a class of pharmacologically important compounds present in over 15 plant families demonstrated to have a wide range of biological activities in humans including anti-cancer, anti-bacterial, and anti-inflammatory...
2017: PloS One
https://www.readbyqxmd.com/read/28570634/neuroprotective-effect-of-bilberry-extract-in-a-murine-model-of-photo-stressed-retina
#5
Hideto Osada, Tomohiro Okamoto, Hirohiko Kawashima, Eriko Toda, Seiji Miyake, Norihiro Nagai, Saori Kobayashi, Kazuo Tsubota, Yoko Ozawa
Excessive exposure to light promotes degenerative and blinding retinal diseases such as age-related macular degeneration and retinitis pigmentosa. However, the underlying mechanisms of photo-induced retinal degeneration are not fully understood, and a generalizable preventive intervention has not been proposed. Bilberry extract is an antioxidant-rich supplement that ameliorates ocular symptoms. However, its effects on photo-stressed retinas have not been clarified. In this study, we examined the neuroprotective effects of bilberry extract against photo-stress in murine retinas...
2017: PloS One
https://www.readbyqxmd.com/read/28556578/fasting-serum-hippuric-acid-is-elevated-after-bilberry-vaccinium-myrtillus-consumption-and-associates-with-improvement-of-fasting-glucose-levels-and-insulin-secretion-in-persons-at-high-risk-of-developing-type-2-diabetes
#6
Vanessa Df de Mello, Maria A Lankinen, Jaana Lindström, Riitta Puupponen-Pimiä, David E Laaksonen, Jussi Pihlajamäki, Marko Lehtonen, Matti Uusitupa, Jaakko Tuomilehto, Marjukka Kolehmainen, Riitta Törrönen, Kati Hanhineva
SCOPE: Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry-enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries and cloudberries (SRC; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism. METHODS AND RESULTS: Hippuric acid was measured with LC-QTOF-MS metabolite profiling analysis from fasting serum samples at baseline and after an 8-week intervention in 47 individuals with features of the metabolic syndrome who were randomized to either a BB diet (n = 15), a SRC diet (n = 20) or a control diet (n = 12)...
May 29, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28499643/pharmacokinetic-profile-of-bilberry-anthocyanins-in-rats-and-the-role-of-glucose-transporters-lc-ms-ms-and-computational-studies
#7
G Baron, A Altomare, L Regazzoni, V Redaelli, S Grandi, A Riva, P Morazzoni, A Mazzolari, M Carini, G Vistoli, G Aldini
The aim of the present investigation was to better understand the pharmacokinetic profile of bilberry (Vaccinium Myrtillus) anthocyanins and the role of glucose transporters (sGLT1 and GLUT2) on their absorption. In particular, the absorption of 15 different anthocyanins contained in a standardized bilberry extract (Mirtoselect(®)) was measured in rats by a validated LC-ESI-MS/MS approach. The plasma concentration peak (Cmax) of 11.1ng/mL was reached after 30min and fasting condition significantly increased the bioavailability of anthocyanins by more than 7 fold in respect to fed rats...
April 27, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28494451/anthocyanins-prevent-colorectal-cancer-development-in-a-mouse-model
#8
Elisabeth Lippert, Petra Ruemmele, Florian Obermeier, Stefan Goelder, Claudia Kunst, Gerhard Rogler, Nadja Dunger, Helmut Messmann, Arndt Hartmann, Esther Endlicher
BACKGROUND: Colorectal cancer is the main leading cause of cancer-related deaths worldwide. Present data suggest that plant-derived anthocyanins have anti-inflammatory and chemopreventive properties. This study was aimed at evaluating the effect of an anthocyanin-rich extract from bilberries on colorectal tumour development and growth in the administration of azoxymethan (AOM)/dextran sodium sulfate (DSS) mouse model. METHODS: Colonic carcinogenesis was induced by AOM and DSS 3 or 5%, respectively, in 50 female Balb/c mice...
May 12, 2017: Digestion
https://www.readbyqxmd.com/read/28492798/medicinal-plants-profile-used-by-the-3rd-district-population-of-macei%C3%A3-al
#9
S A S Griz, T J Matos-Rocha, A F Santos, J G Costa, K C Mousinho
Herein the use of medicinal plants by the population of the 3rd Sanitary District of Maceió-AL city is reported. Transversal description was conducted from February 2013 to January 2014, with a sample of 116 individuals of both Gender Genders aged over 18 years. The ethnobotanical information interviews ethnobotanical information were obtained through semi - structured questionnaire featuring the use of medicinal plants and social and economical data. Descriptive statistics was applied for quantitative variables as mean and standard deviation and proportions for qualitative variables in the frequency table format...
May 4, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28452948/chemical-composition-antioxidant-and-%C3%AE-glucosidase-inhibiting-activities-of-the-aqueous-and-hydroethanolic-extracts-of-vaccinium-myrtillus-leaves
#10
Kristina Bljajić, Roberta Petlevski, Lovorka Vujić, Ana Čačić, Nina Šoštarić, Jasna Jablan, Isabel Saraiva de Carvalho, Marijana Zovko Končić
Vaccinium myrtillus (bilberry) leaf is traditionally used in southeastern Europe for the treatment of diabetes. In the present study, the ability of bilberry leaf extracts to inhibit carbohydrate-hydrolyzing enzymes and restore glutathione concentration in Hep G2 cells subjected to glucose-induced oxidative stress was investigated. A comprehensive analysis of the antioxidant activity of two bilberry leaf extracts was performed. The aqueous extract showed excellent total antioxidant and chelating activity. Its antioxidant activity in the β-carotene-linoleic acid assay was very good, reaching the activity of the antioxidant standard BHA (93...
April 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28450007/human-intervention-study-to-investigate-the-intestinal-accessibility-and-bioavailability-of-anthocyanins-from-bilberries
#11
Dolores Mueller, Kathrin Jung, Manuel Winter, Dorothee Rogoll, Ralph Melcher, Elke Richling
We investigated the importance of the large intestine on the bioavailability of anthocyanins from bilberries in humans with/without a colon. Low bioavailability of anthocyanins in plasma and urine was observed in the frame of this study. Anthocyanins reached the circulation mainly as glucuronides. Analysis of ileal effluents (at end of small intestine) demonstrated that 30% of ingested anthocyanins were stable during 8h passage through the upper intestine. Only 20% degradants were formed and mostly intact anthocyanins were absorbed from the small intestine...
September 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28374224/effects-of-insect-herbivory-on-bilberry-production-and-removal-of-berries-by-frugivores
#12
Tuuli-Marjaana Koski, Marika Kalpio, Toni Laaksonen, Päivi M Sirkiä, Heikki P Kallio, Baoru Yang, Kaisa M Linderborg, Tero Klemola
The evolutionary purpose of a fleshy fruit is to attract seed dispersers and get the seeds dispersed by frugivorous animals. For this reason, fruits should be highly rewarding to these mutualists. However, insect herbivory can alter plant reproductive success e.g. by decreasing fruit yield or affecting the attractiveness of the fruits to mutualistic seed dispersers. Under natural conditions, we tested the effects of experimental larval-defoliation on berry ripening and consumption of a non-cultivated dwarf shrub, the bilberry (Vaccinium myrtillus L...
April 3, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28331586/how-to-induce-defense-responses-in-wild-plant-populations-using-bilberry-vaccinium-myrtillus-as-example
#13
Tarald Seldal, Stein Joar Hegland, Knut Rydgren, Cesar Rodriguez-Saona, Joachim Paul Töpper
Inducible plant defense is a beneficial strategy for plants, which imply that plants should allocate resources from growth and reproduction to defense when herbivores attack. Plant ecologist has often studied defense responses in wild populations by biomass clipping experiments, whereas laboratory and greenhouse experiments in addition apply chemical elicitors to induce defense responses. To investigate whether field ecologists could benefit from methods used in laboratory and greenhouse studies, we established a randomized block-design in a pine-bilberry forest in Western Norway...
March 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28202351/exosomal-formulation-of-anthocyanidins-against-multiple-cancer-types
#14
Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan, Ashish K Agrawal, Ashley M Mudd, Al Hassan Kyakulaga, Inder P Singh, Manicka V Vadhanam, Ramesh C Gupta
Over the last two decades, berries and berry bioactives, particularly anthocyanins and their aglycones anthocyanidins (Anthos) have demonstrated excellent anti-oxidant, anti-proliferative, apoptotic and anti-inflammatory properties. However, their physicochemical and pharmacokinetic limitations such as, low permeability, and poor oral bioavailability are considered as unfavorable properties for development as drugs. Therefore there is a need to develop systems for efficient systemic delivery and robust bioavailability...
February 12, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28106822/red-fruits-extraction-of-antioxidants-phenolic-content-and-radical-scavenging-determination-a-review
#15
REVIEW
Gádor-Indra Hidalgo, María Pilar Almajano
Red fruits, as rich antioxidant foods, have gained over recent years capital importance for consumers and manufacturers. The industrial extraction of the phenolic molecules from this source has been taking place with the conventional solvent extraction method. New non-conventional extraction methods have been devised as environmentally friendly alternatives to the former method, such as ultrasound, microwave, and pressure assisted extractions. The aim of this review is to compile the results of recent studies using different extraction methodologies, identify the red fruits with higher antioxidant activity, and give a global overview of the research trends regarding this topic...
January 19, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28036078/dibasic-ammonium-phosphate-application-enhances-aromatic-compound-concentration-in-bog-bilberry-syrup-wine
#16
Shao-Yang Wang, Yi-Qing Li, Teng Li, Hang-Yu Yang, Jie Ren, Bo-Lin Zhang, Bao-Qing Zhu
A nitrogen deficiency always causes bog bilberry syrup wine to have a poor sensory feature. This study investigated the effect of nitrogen source addition on volatile compounds during bog bilberry syrup wine fermentation. The syrup was supplemented with 60, 90, 120 or 150 mg/L dibasic ammonium phosphate (DAP) before fermentation. Results showed that an increase of DAP amounts accelerated fermentation rate, increased alcohol content, and decreased sugar level. Total phenol and total flavonoid content were also enhanced with the increase of DAP amounts...
December 29, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28025668/ericoid-roots-and-mycospheres-govern-plant-specific-bacterial-communities-in-boreal-forest-humus
#17
Sari Timonen, Hanna Sinkko, Hui Sun, Outi-Maaria Sietiö, Johanna M Rinta-Kanto, Heikki Kiheri, Jussi Heinonsalo
In this study, the bacterial populations of roots and mycospheres of the boreal pine forest ericoid plants, heather (Calluna vulgaris), bilberry (Vaccinium myrtillus), and lingonberry (Vaccinium vitis-idaea), were studied by qPCR and next-generation sequencing (NGS). All bacterial communities of mycosphere soils differed from soils uncolonized by mycorrhizal mycelia. Colonization by mycorrhizal hyphae increased the total number of bacterial 16S ribosomal DNA (rDNA) gene copies in the humus but decreased the number of different bacterial operational taxonomic units (OTUs)...
December 26, 2016: Microbial Ecology
https://www.readbyqxmd.com/read/27993193/intake-of-bilberries-vaccinium-myrtillus-l-reduced-risk-factors-for-cardiovascular-disease-by-inducing-favorable-changes-in-lipoprotein-profiles
#18
Marta Habanova, Jorge A Saraiva, Miroslav Haban, Marianna Schwarzova, Peter Chlebo, Lenka Predna, Jan Gažo, Joanna Wyka
Cardiovascular diseases (CVDs) are the leading causes of death, and lifestyle modification, including dietary changes, is recommended to improve this condition. In this study, regular consumption of bilberries was hypothesized to have beneficial effects on CVD risk reduction, by changes in human health indicators such as decreasing low-density lipoprotein cholesterol (LDL-C) and triglycerides (TGs) and increasing high-density lipoprotein cholesterol (HDL-C). The research involved women (n=25) and men (n=11) who consumed 150 g of frozen stored bilberries 3 times a week for 6 weeks...
December 2016: Nutrition Research
https://www.readbyqxmd.com/read/27865612/changes-in-intestinal-immunity-gut-microbiota-and-expression-of-energy-metabolism-related-genes-explain-adenoma-growth-in-bilberry-and-cloudberry-fed-apc-min-mice
#19
Essi Päivärinta, Mikael Niku, Johanna Maukonen, Markus Storvik, Anu Heiman-Lindh, Maria Saarela, Anne-Maria Pajari, Marja Mutanen
We showed previously that ellagitannin-rich cloudberries and anthocyanin-rich bilberries reduce the number of intestinal adenomas in multiple intestinal neoplasia/+ (Apc(Min)) mice. We also found that cloudberries decreased the size of adenomas, whereas bilberries increased it. Here we hypothesized that the difference in adenoma growth could be explained by dissimilar effects of the berries on intestinal immune responses and gut microbiota, potentially driven by the distinct polyphenol compositions of the 2 berries...
November 2016: Nutrition Research
https://www.readbyqxmd.com/read/27855899/phenolic-compounds-extracted-by-acidic-aqueous-ethanol-from-berries-and-leaves-of-different-berry-plants
#20
Ye Tian, Jaana Liimatainen, Aino-Liisa Alanne, Anni Lindstedt, Pengzhan Liu, Jari Sinkkonen, Heikki Kallio, Baoru Yang
Phenolic compounds of berries and leaves of thirteen various plant species were extracted with aqueous ethanol and analyzed with UPLC-DAD-ESI-MS, HPLC-DAD, and NMR. The total content of phenolics was consistently higher in leaves than in berries (25-7856 vs. 28-711mg/100g fresh weight). Sea buckthorn leaves were richest in phenolic compounds (7856mg/100g f.w.) with ellagitannins as the dominant compound class. Sea buckthorn berries contained mostly isorhamnetin glycosides, whereas quercetin glycosides were typically abundant in most samples investigated...
April 1, 2017: Food Chemistry
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