keyword
MENU ▼
Read by QxMD icon Read
search

PABA

keyword
https://www.readbyqxmd.com/read/27905500/targeting-intracellular-p-aminobenzoic-acid-production-potentiates-the-anti-tubercular-action-of-antifolates
#1
Joshua M Thiede, Shannon L Kordus, Breanna J Turman, Joseph A Buonomo, Courtney C Aldrich, Yusuke Minato, Anthony D Baughn
The ability to revitalize and re-purpose existing drugs offers a powerful approach for novel treatment options against Mycobacterium tuberculosis and other infectious agents. Antifolates are an underutilized drug class in tuberculosis (TB) therapy, capable of disrupting the biosynthesis of tetrahydrofolate, an essential cellular cofactor. Based on the observation that exogenously supplied p-aminobenzoic acid (PABA) can antagonize the action of antifolates that interact with dihydropteroate synthase (DHPS), such as sulfonamides and p-aminosalicylic acid (PAS), we hypothesized that bacterial PABA biosynthesis contributes to intrinsic antifolate resistance...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27853705/shelf-life-evaluation-of-ricotta-fresca-sheep-cheese-in-modified-atmosphere-packaging
#2
Carlo Pala, Christian Scarano, Massimiliano Venusti, Daniela Sardo, Daniele Casti, Francesca Cossu, Sonia Lamon, Vincenzo Spanu, Michela Ibba, Michela Marras, Antonio Paba, Carlo Spanu, Enrico Pietro Luigi De Santis
Ricotta fresca cheese is the product of Sardinian dairy industry most exposed to microbial post-process contamination. Due to its technological characteristics, intrinsic parameters, pH (6.10-6.80) and water activity (0.974-0.991), it represents an excellent substrate for the growth of spoilage and pathogenic microorganisms, which are usually resident in cheese-making plants environments. Generally, ricotta fresca has a shelf life of 5-7 days. For this reason, at industrial level, modified atmosphere packaging (MAP) is used to extend the durability of the product...
June 3, 2016: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/27827943/a-spatial-hierarchical-analysis-of-the-temporal-influences-of-the-el-ni%C3%A3-o-southern-oscillation-and-weather-on-dengue-in-kalutara-district-sri-lanka
#3
Prasad Liyanage, Hasitha Tissera, Maquins Sewe, Mikkel Quam, Ananda Amarasinghe, Paba Palihawadana, Annelies Wilder-Smith, Valérie R Louis, Yesim Tozan, Joacim Rocklöv
Dengue is the major public health burden in Sri Lanka. Kalutara is one of the highly affected districts. Understanding the drivers of dengue is vital in controlling and preventing the disease spread. This study focuses on quantifying the influence of weather variability on dengue incidence over 10 Medical Officer of Health (MOH) divisions of Kalutara district. Weekly weather variables and data on dengue notifications, measured at 10 MOH divisions in Kalutara from 2009 to 2013, were retrieved and analysed. Distributed lag non-linear model and hierarchical-analysis was used to estimate division specific and overall relationships between weather and dengue...
November 4, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27806428/daratumumab-elotuzumab-and-the-development-of-therapeutic-monoclonal-antibodies-in-multiple-myeloma
#4
Jacob P Laubach, Claudia E Paba Prada, Paul G Richardson, Dan L Longo
There has been substantial progress in clinical outcomes for patients with multiple myeloma. This encouraging trend derives in large part from the increasing number of effective therapeutic options and the ability as a result of this to achieve higher quality responses to treatment. The approval of both daratumumab and of elotuzumab in combination with lenalidomide and dexamethasone in late 2015 was a notable achievement in the field, as daratumumab and elotuzumab represent the first monoclonal antibodies available for use in multiple myeloma...
November 2, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27796094/analysis-of-the-biotechnological-potential-of-a-lentinus-crinitus-isolate-in-the-light-of-its-secretome
#5
Geison Cambri, Mirta Mittelstedt Leal de Sousa, Davi de Miranda Fonseca, Fabricio Marchini, Joana Lea Meira da Silveira, Jaime Paba
Analysis of fungal secretomes is a prospection tool for the discovery of new catalysts with biotechnological application. Since enzyme secretion is strongly modulated by environmental factors, evaluation of growth conditions is of utmost importance to achieve optimal enzyme production. Here, a non-sequenced wood-rotting fungus, L. crinitus, was used for secretome analysis by enzymatic assays and a proteomics approach. Enzyme production was assessed after culturing the fungus in five different carbon sources and three nitrogen containing compounds...
October 31, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27734316/degradation-of-triclosan-in-the-presence-of-p-aminobenzoic-acid-under-simulated-sunlight-irradiation
#6
Pingping Zhai, Xuan Chen, Wenbo Dong, Hongjing Li, Jean-Marc Chovelon
This study aimed to investigate the degradation of triclosan (TCS) in the presence of p-aminobenzoic acid (PABA) under simulated sunlight irradiation (λ ≥ 290 nm). The effect of PABA concentration, pH, dissolved organic matter (DOM), and DOM-hydrolytic Fe(III) species complexes on the photodegradation of TCS in the presence of PABA (TCS-PABA) was also studied. The photolysis of TCS-PABA obeyed pseudo-first-order kinetics well, and the degradation of TCS-PABA enhanced with increasing solution pH (from 3...
October 13, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27723351/aggregate-elasticity-crystal-structure-and-tableting-performance-for-p-aminobenzoic-acid-and-a-series-of-its-benzoate-esters
#7
Aditya B Singaraju, Kyle Nguyen, Abhay Jain, Rahul V Haware, Lewis L Stevens
The tableting performance for p-aminobenzoic acid (PABA) and a series of its benzoate esters with increasing alkyl chain length (methyl-, ethyl- and n-butyl) was determined over a broad range of compaction pressures. The crystalline structure of methyl benzoate (Me-PABA) exhibits no slip systems and does not form viable compacts under any compaction pressure. The ethyl (Et-PABA) and n-butyl (Bu-PABA) esters each have a similar, corrugated-layer structure that displays a prominent slip plane and improves material plasticity at low compaction pressure...
October 10, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27711471/the-influence-of-solution-environment-on-the-nucleation-kinetics-and-crystallisability-of-para-aminobenzoic-acid
#8
T D Turner, D M C Corzo, D Toroz, A Curtis, M M Dos Santos, R B Hammond, X Lai, K J Roberts
The influence of solvent type on the solution thermodynamics, nucleation-kinetics and crystal growth of alpha para-aminobenzoic acid (PABA) crystallising from supersaturated ethanol, acetonitrile and water solutions, is examined using poly-thermal analysis of the metastable zone width. Application of a recently proposed model for analysis of crystallisation kinetics (J. Cryst. Growth, 2010, 312, 698-704) indicates a solvent and concentration dependence of the nucleation mechanism and key nucleation parameters for the alpha form of PABA...
October 5, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27696263/treatment-of-relapsed-refractory-multiple-myeloma
#9
Paola Neri, Nizar J Bahlis, Claudia Paba-Prada, Paul Richardson
Survival outcomes of patients with Multiple Myeloma (MM) have improved over the last decade due to the introduction of novel agents such as the immunomodulatory drugs thalidomide, lenalidomide (Len) and pomalidomide, and the proteasome inhibitors bortezomib (BTZ) and carfilzomib [1, 2]. However, despite these major advances, MM remains largely incurable and almost all patients relapse and require additional therapy [3]. The successful introduction of next generation novel agents including oral proteasome inhibitors, deacetylase inhibitors, and especially monoclonal antibodies as part of immunotherapy promises to further improve outcome...
2016: Cancer Treatment and Research
https://www.readbyqxmd.com/read/27635025/a-systematic-approach-for-developing-bacteria-specific-imaging-tracers
#10
Alvaro A Ordonez, Edward A Weinstein, Lauren E Bambarger, Vikram Saini, Yong S Chang, Vincent P DeMarco, Mariah H Klunk, Michael E Urbanowski, Kimberly L Moulton, Allison M Murawski, Supriya Pokkali, Alvin S Kalinda, Sanjay K Jain
: The modern patient is increasingly susceptible to bacterial infections including those due to multi-drug resistant organisms (MDROs). Noninvasive whole-body analysis with pathogen-specific imaging technologies can significantly improve patient outcomes by rapidly identifying a source of infection and monitoring the response to treatment, but no such technology exists clinically. METHODS: We systematic screened 961 random, radiolabeled molecules in silico as substrates for essential metabolic pathways in bacteria, followed by in vitro uptake in representative bacteria - Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and mycobacteria...
September 15, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27535155/homogeneous-photocatalytic-oxidation-of-uv-filter-para-aminobenzoic-acid-in-aqueous-solutions
#11
Sophia Tsoumachidou, Dimitra Lambropoulou, Ioannis Poulios
The presence of personal care product (PCP) residues in the aquatic environment is an emerging issue due to their uncontrolled release through graywater; for this reason, efforts are being made to develop methods to inactivate or eliminate this class of substances in the environment. In this work, homogeneous photocatalysis has been applied for the degradation of UV filter para-aminobenzoic acid (PABA), which exists in several types of PCPs, in order to identify the optimum degradation conditions. The oxidation of PABA by photo-Fenton and oxalate-induced photo-Fenton (ferrioxalate) processes was investigated, and the effect of various operating variables has been assessed, i...
August 18, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27529387/unveiling-self-sensitized-photodegradation-pathways-by-dft-calculations-a-case-of-sunscreen-p-aminobenzoic-acid
#12
Siyu Zhang, Jingwen Chen, Qing Zhao, Qing Xie, Xiaoxuan Wei
Self-sensitized photodegradation has been observed for diverse aquatic organic pollutants. However, photodegradation pathways have not been clarified in previous experimental studies. Here, we attempted to probe self-sensitized photodegradation pathways of organic pollutants employing both photolytic experiments and density functional theory calculations. By performing photolytic experiments, we found that singlet state oxygen ((1)O2) play an essential role in photodegradation of a sunscreen p-aminobenzoic acid (PABA)...
November 2016: Chemosphere
https://www.readbyqxmd.com/read/27471069/production-of-para-aminobenzoate-by-genetically-engineered-corynebacterium-glutamicum-and-non-biological-formation-of-an-n-glucosyl-byproduct
#13
Takeshi Kubota, Akira Watanabe, Masako Suda, Takahisa Kogure, Kazumi Hiraga, Masayuki Inui
para-Aminobenzoate (PABA), a valuable chemical raw material, can be synthesized by most microorganisms. This aromatic compound is currently manufactured from petroleum-derived materials by chemical synthesis. To produce PABA from renewable resources, its production by fermentation was investigated. The evaluation of the sensitivity to PABA toxicity revealed that Corynebacterium glutamicum had better tolerance to PABA than several other microorganisms. To produce PABA from glucose, genetically engineered C. glutamicum was constructed by introducing both pabAB and pabC...
July 25, 2016: Metabolic Engineering
https://www.readbyqxmd.com/read/27467016/nation-wide-measure-of-variability-in-hcmv-ebv-and-bkv-dna-quantification-among-centers-involved-in-monitoring-transplanted-patients
#14
Isabella Abbate, Antonio Piralla, Agata Calvario, Annapaola Callegaro, Cristina Giraldi, Giovanna Lunghi, William Gennari, Giuseppe Sodano, Paolo Ravanini, Pier Giulio Conaldi, Marialinda Vatteroni, Aurelia Gaeta, Pierpaolo Paba, Rossana Cavallo, Fausto Baldanti, Tiziana Lazzarotto
BACKGROUND: Inter-laboratory variability in quantifying pathogens involved in viral disease following transplantation may have a great impact on patient care, especially when pre-emptive strategies are used for prevention. OBJECTIVES: The aim of this study was to analyze the variability in quantifying CMV, EBV and BKV DNA from 15 virology laboratories of the Italian Infections in Transplant Working Group (GLaIT) involved in monitoring transplanted patients. STUDY DESIGN: Panels from international Quality Control programs for Molecular Diagnostics (QCMD, year 2012), specific for the detection of CMV in plasma, CMV in whole blood (WB), EBV and BKV were used...
September 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27375262/genomic-approach-to-studying-nutritional-requirements-of-clostridium-tyrobutyricum-and-other-clostridia-causing-late-blowing-defects
#15
Michelangelo Storari, Sandra Kulli, Daniel Wüthrich, Rémy Bruggmann, Hélène Berthoud, Emmanuelle Arias-Roth
Clostridium tyrobutyricum is the main microorganism responsible for the late blowing defect in hard and semi-hard cheeses, causing considerable economic losses to the cheese industry. Deeper knowledge of the metabolic requirements of this microorganism can lead to the development of more effective control approaches. In this work, the amino acids and B vitamins essential for sustaining the growth of C. tyrobutyricum were investigated using a genomic approach. As the first step, the genomes of four C. tyrobutyricum strains were analyzed for the presence of genes putatively involved in the biosynthesis of amino acids and B vitamins...
October 2016: Food Microbiology
https://www.readbyqxmd.com/read/27315123/vitamins-for-enhancing-plant-resistance
#16
REVIEW
Hatem Boubakri, Mahmoud Gargouri, Ahmed Mliki, Faiçal Brini, Julie Chong, Moez Jbara
This paper provides an overview on vitamins with inducing activities in plants, the molecular and cellular mechanisms implicated, and the hormonal signalling-network regulating this process. Moreover, it reports how vitamins might be part of the molecular events linked to induced resistance by the conventional elicitors. Induced resistance (IR), exploiting the plant innate-defense system is a sustainable strategy for plant disease control. In the last decade, vitamins have been proven to act as inducers of disease resistance, and these findings have received an important attention owing to their safety and cost effectiveness...
September 2016: Planta
https://www.readbyqxmd.com/read/27241954/characteristics-of-and-factors-associated-with-dengue-vector-breeding-sites-in-the-city-of-colombo-sri-lanka
#17
Valérie R Louis, Carlos Alberto Montenegro Quiñonez, Pad Kusumawathie, Paba Palihawadana, Sakoo Janaki, Yesim Tozan, Ruwan Wijemuni, Annelies Wilder-Smith, Hasitha A Tissera
INTRODUCTION: Dengue has emerged as a major public health problem in Sri Lanka. Vector control at community level is a frequent and widespread strategy for dengue control. The aim of the study was to assess Aedes mosquito breeding sites and the prevention practices of community members in a heavily urbanized part of Colombo. METHODS: A cross-sectional entomological survey was conducted from April to June 2013 in 1469 premises located in a subdistrict of the City of Colombo...
March 2016: Pathogens and Global Health
https://www.readbyqxmd.com/read/27235899/environmental-occurrence-and-ecological-risk-assessment-of-organic-uv-filters-in-marine-organisms-from-hong-kong-coastal-waters
#18
Ziye Sang, Kelvin Sze-Yin Leung
Organic UV filters, now considered to be emerging contaminants in aquatic ecosystems, are being intensively tracked in environmental waters worldwide. However, their environmental fate and impact of these contaminants on marine organisms remains largely unknown, especially in Asia. This work elucidates the occurrence and the ecological risks of seven UV filters detected in farmed fish, wild mussels and some other wild organisms collected from local mariculture farms in Hong Kong. For all of the organisms, ethylhexyl methoxycinnamate (EHMC) and octyl dimethyl p-aminobenzoic acid (OD-PABA) were the predominant contaminants with the highest concentrations up to 51...
October 1, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27232656/deuterium-labeled-precursor-feeding-reveals-a-new-paba-containing-meroterpenoid-from-the-mango-pathogen-xanthomonas-citri-pv-mangiferaeindicae
#19
Hesham Saleh, Daniel Petras, Andi Mainz, Dennis Kerwat, Ayse Nalbantsoy, Yalcin Erzurumlu, Roderich D Süssmuth
A new para-aminobenzoic-acid-containing natural product from the mango pathogenic organism Xanthomonas citri pv. mangiferaeindicae is described. By means of stable isotope precursor feeding combined with nontargeted LC-MS/MS, the generated spectra were clustered and visualized in a molecular network. This led to the identification of a new member of the meroterpenoids, termed xanthomonic acid, which is composed of an isoprenylated para-aminobenzoic acid. In vitro cytotoxicity assays demonstrated activity of xanthomonic acid against several human cancer cell lines by induction of autophagy...
June 24, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27230236/production-of-para-aminobenzoic-acid-from-different-carbon-sources-in-engineered-saccharomyces-cerevisiae
#20
Nils J H Averesch, Gal Winter, Jens O Krömer
BACKGROUND: Biological production of the aromatic compound para-aminobenzoic acid (pABA) is of great interest to the chemical industry. Besides its application in pharmacy and as crosslinking agent for resins and dyes pABA is a potential precursor for the high-volume aromatic feedstocks terephthalic acid and para-phenylenediamine. The yeast Saccharomyces cerevisiae synthesises pABA in the shikimate pathway: Outgoing from the central shikimate pathway intermediate chorismate, pABA is formed in two enzyme-catalysed steps, encoded by the genes ABZ1 and ABZ2...
2016: Microbial Cell Factories
keyword
keyword
36375
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"