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Tiziana Lazzarotto, Angela Chiereghin, Antonio Piralla, Giulia Piccirilli, Alessia Girello, Giulia Campanini, Liliana Gabrielli, Cristina Costa, Arcangelo Prete, Francesca Bonifazi, Alessandro Busca, Roberto Cairoli, Anna Amelia Colombo, Marco Zecca, Francesca Sidoti, Gabriele Bianco, Pierpaolo Paba, Carlo Federico Perno, Rossana Cavallo, Fausto Baldanti
Currently, no consensus has been reached on the optimal blood compartment to be used for surveillance of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) DNAemia. Although several comparative studies have been performed correlating CMV and EBV DNA loads in whole blood (WB) vs plasma, to our knowledge, no studies have ever analyzed the kinetics of both viruses in the two blood compartments. In this retrospective non-interventional multicenter cohort study the kinetics of CMV and EBV DNA in 121 hematopoietic stem cell transplant recipients (HSCTR) have been investigated by analyzing in parallel 569 and 351 paired samples from 80 and 58 sequential episodes of CMV and EBV DNAemia, respectively...
March 12, 2018: Biology of Blood and Marrow Transplantation
Libo Zhang, Yanmei Xu, Thomas M Makris, Qian Wang
A novel N-oxygenase coated core-shell nanoparticle was generated through the co-assembly of poly(4-vinylpyridine) (P4VP) and arylamine N-oxygenase CmlI. The resulting enzyme-hybridized particles, P4VP-CmlI, showed excellent catalytic activities on the oxidation of two arylamine substrates, i.e. p-aminophenol (pAP) and p-aminobenzoic acid (pABA), using a surrogate redox system or a peroxide shunt as co-oxidants. In comparison to the free enzyme, P4VP-CmlI particles exhibited a significantly enhanced catalytic efficiency when using pyridine nucleotide (NADH) and proper redox mediators...
February 20, 2018: Biomacromolecules
Gonzalo E Fenoy, Juan M Giussi, Catalina von Bilderling, Eliana M Maza, Lía I Pietrasanta, Wolfgang Knoll, Waldemar A Marmisollé, Omar Azzaroni
We present the covalent modification of a Pani-like conducting polymer (polyaminobenzylamine, PABA) by grafting of a polyelectrolyte brush (poly [2-(methacryloyloxy)-ethyl-trimethylammonium chloride], PMETAC). As PABA has extra pendant amino moieties, the grafting procedure does not affect the backbone nitrogen atoms that are implicated in the electronic structure of the conducting polymers. Moreover, perchlorate anions interact very strongly with the quaternary ammonium pendant groups of PMETAC through ion pairing...
February 7, 2018: Journal of Colloid and Interface Science
Roberto Cameriere, Luz Andrea Velandia Palacio, Jorge Pinares, Fiorella Bestetti, Rossella Paba, Erminia Coccia, Luigi Ferrante
This retrospective cross-sectional study has two-fold aims: the first is to assess new cut-offs at the legal age thresholds (LATs) of 14 and 16 years old and the second is to validate the cut-off of third molar index I3M=0.08 for 18 years of age in Chilean people. Orthopantomographs from 822 Chilean children aged from 11 to 22 (472 girls and 350 boys) were analysed. For LAT of 14 years, cut-offs were found using the ROC curves singly for boys and girls. The cut-offs for boys were I2M=0.16 and I3M=0.73 while for girls we obtained I2M=0...
January 8, 2018: Forensic Science International
Dany Siverio-Mota, Isabel Andujar, Yovani Marrero-Ponce, Rosa M Giner, Claudia Diaz Mendoza, Ganiveth Manjarrez Paba, Liliana Vicet-Muro, Maria Lorena Cordero-Maldonado, Peter A M de Witte, Alexander D Crawford, Maite Sylla-Iyarreta Veitia, Facundo Perez-Jimenez, Vicente J Aran
After the identification of the anti-inflammatory properties of the VA5-13l (2-benzyl-1-methyl-5-nitroindazolinone) in previous investigations, some analogous compounds of them were designed, synthesized and evaluated in two anti-inflammatory methods: LPS-enhanced leukocyte migration assay in zebrafish and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema. Of the products evaluates (3, 6, 8, 9 and 10) showed the lower values of relative leukocyte migration at 30 µM (0.14, 0.07, 0.10, 0.13 and 0...
January 19, 2018: Current Topics in Medicinal Chemistry
Pedro Laborda, Yangyang Zhao, Jun Ling, Rongxian Hou, Fengquan Liu
Among Lysobacter species, Lysobacter antibioticus has been demonstrated to be an interesting source of antimicrobial metabolites for the biocontrol of plant diseases. Although the antibacterial activity was attributed to N-oxide phenazines, the active compounds involved in the antifungal function remained unknown. In this work, an antifungal compound has been isolated and identified as p-aminobenzoic acid (pABA). Antifungal activity screening revealed that pABA shows activity against a number of plant pathogens...
December 28, 2017: Journal of Agricultural and Food Chemistry
Maryam A Z El-Attar, Rasha Y Elbayaa, Omaima G Shaaban, Nargues S Habib, Abeer E Abdel Wahab, Ibrahim A Abdelwahab, Soad A M El-Hawash
Development of new antimicrobial agents is a good solution to overcome drug-resistance problems. From this perspective, new quinoxaline derivatives bearing various bioactive heterocyclic moieties (thiadiazoles, oxadiazoles, pyrazoles and thiazoles) were designed and synthesized. The newly synthesized compounds were evaluated for their in vitro antibacterial activity against nine bacterial human pathogenic strains using the disc diffusion assay. In general, most of the synthesized compounds exhibited good antibacterial activities...
December 5, 2017: Bioorganic Chemistry
Si-Yin Chung, Christopher P Mattison, Casey C Grimm, Shawndrika Reed
Whole peanut or cashew extracts are usually used in immunotherapy. Reducing major allergen(s) in the extracts may lessen their side effects. Three methods were evaluated to reduce major allergens in peanut extracts: (1) p -aminobenzamidine; (2) magnetic agarose beads; and (3) extraction of a commercial peanut flour at pH 7, respectively. The first two methods were also used to reduce major allergens in cashew extracts. After treatments, samples were evaluated by SDS-PAGE. pABA-treated samples were also analyzed for IgE binding in western blot...
November 2017: Food Science & Nutrition
Matthew L Dennis, Michael D Lee, Jitendra R Harjani, Mohamed Ahmed, Aaron J DeBono, Noel P Pitcher, Zhong-Chang Wang, Sandeep Chhabra, Nicholas Barlow, Raphaël Rahmani, Ben Cleary, Olan Dolezal, Meghan Hattarki, Luigi Aurelio, Jeremy Shonberg, Bim Graham, Thomas S Peat, Jonathan B Baell, James D Swarbrick
Dihydropteroate synthase (DHPS) is an enzyme of the folate biosynthesis pathway, which catalyzes the formation of 7,8-dihydropteroate (DHPt) from 6-hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPPP) and para-aminobenzoic acid (pABA). DHPS is the long-standing target of the sulfonamide class of antibiotics that compete with pABA. In the wake of sulfa drug resistance, targeting the structurally rigid (and more conserved) pterin site has been proposed as an alternate strategy to inhibit DHPS in wild-type and sulfa drug resistant strains...
February 6, 2018: Chemistry: a European Journal
Han M Gan, Yin P Lee, Christopher M Austin
We improved upon the previously reported draft genome of Hydrogenophaga intermedia strain PBC, a 4-aminobenzenesulfonate-degrading bacterium, by supplementing the assembly with Nanopore long reads which enabled the reconstruction of the genome as a single contig. From the complete genome, major genes responsible for the catabolism of 4-aminobenzenesulfonate in strain PBC are clustered in two distinct genomic regions. Although the catabolic genes for 4-sulfocatechol, the deaminated product of 4-aminobenzenesulfonate, are only found in H...
2017: Frontiers in Microbiology
Angela Gioffrè, Antonella Marramao, Ignazio DI Gesu, Pasquale Samele, Emilia Paba, Anna Marcelloni, Alessandra Chiominto, Sergio Iavicoli
The peculiar characteristics of the greenhouses as confined spaces, microclimate and poor air exchange with the outside environment, encourage the development of a large number of biological agents. Endotoxin, is probably a major causative agent of occupational health problems. The objective of this study was to measure the concentrations of airborne endotoxin in greenhouses with different cultures. The influence of microclimate was studied in correlation with endotoxin levels and type of cultured vegetables...
October 19, 2017: Industrial Health
Raúl A Salazar-González, Eneida Turiján-Espinoza, David W Hein, Perla C Niño-Moreno, Silvia Romano-Moreno, Rosa C Milán-Segovia, Diana P Portales-Pérez
Human arylamine N-acetyltransferase 1 (NAT1) is responsible for the activation and elimination of xenobiotic compounds and carcinogens. Genetic polymorphisms in NAT1 modify both drug efficacy and toxicity. Previous studies have suggested a role for NAT1 in the development of several diseases. The aim of the present study was to evaluate NAT1 protein expression and in situ N-acetylation capacity in peripheral blood mononuclear cells (PBMC), as well as their possible associations with the expression of NAT1 transcript and NAT1 genotype...
October 17, 2017: Archives of Toxicology
Leticia Vidal-Liñán, Eugenia Villaverde-de-Sáa, Rosario Rodil, José Benito Quintana, Ricardo Beiras
In this study the bioaccumulation kinetics of organic UV filters, such as 4-MBC, BP-3, BP-4, OC and OD-PABA in wild Mytilus galloprovincialis mussels was investigated. The uptake and accumulation of waterborne 4-MBC, BP-4 and OC was very rapid, and after only 24 h of exposure to 1 μg L(-1), the tissular concentrations were 418, 263 and 327 μg kg(-1)d.w., respectively. The kinetics of bioaccumulation of BP-4 and OC significantly fitted to an asymptotic model with BCF values of 905 L kg(-1) and 2210 L kg(-1), respectively...
September 29, 2017: Chemosphere
Tomaz Langenbach, Denise Mano, Maize M Campos, Alessandra L M C Cunha, Tácio M P De Campos
Pesticide air pollution by spraying was evaluated under different temperature, humidity and wind climatic conditions in Brazil. Field experiments were performed with application towards the soil and in guava orchards, where spray dispersion was monitored by adding p-aminobenzoic acid (PABA), a fluorescent substance, as a tracer to the water contained in the spray tanks. Samples were collected with filter membranes (Whatman 180025), and the PABA was extracted from the filters by shaking with water in a Petri dish and measured in a spectrofluorometer...
September 26, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
Masae Kuboniwa, John R Houser, Erik L Hendrickson, Qian Wang, Samar A Alghamdi, Akito Sakanaka, Daniel P Miller, Justin A Hutcherson, Tiansong Wang, David A C Beck, Marvin Whiteley, Atsuo Amano, Huizhi Wang, Edward M Marcotte, Murray Hackett, Richard J Lamont
Many human infections are polymicrobial in origin, and interactions among community inhabitants shape colonization patterns and pathogenic potential (1) . Periodontitis, which is the sixth most prevalent infectious disease worldwide (2) , ensues from the action of dysbiotic polymicrobial communities (3) . The keystone pathogen Porphyromonas gingivalis and the accessory pathogen Streptococcus gordonii interact to form communities in vitro and exhibit increased fitness in vivo (3,4) . The mechanistic basis of this polymicrobial synergy, however, has not been fully elucidated...
November 2017: Nature Microbiology
Qian Qian Zhang, Bin Bin Chen, Hong Yan Zou, Yuan Fang Li, Cheng Zhi Huang
Hematin plays a crucial role in various physiological functions, and the determination of hematin in complex biological matrixes is a significant but difficult issue. Considering the unique photophysical/photochemical properties of carbon quantum dots (CQDs) prepared with p-aminobenzoic acid (PABA) and ethanol, a new strategy for the design of fluorescent probes for hematin has been achieved. The proposed sensor array is fabricated based on the inner filter effect (IFE) between hematin and CQDs with phenomenon of selective fluorescence quenching of CQDs which results from the strong absorption of the excitation and emission spectrum of CQDs by hematin...
August 24, 2017: Biosensors & Bioelectronics
Meltem Erol, Ismet Çok, Özlem Bostan Gayret, Pembegül Günes, Özgül Yigit, Elif Sayman, Aysegül Günes, Duygu Sultan Çelik, Sahin Hamilçikan, Serdar Altinay, Oya Ercan
Homosalate (HMS) and 2-ethylhexyl 4-dimethylaminobenzoate (OD-PABA) are ultraviolet filters. We aimed to investigate the effects of dermal exposure to HMS and OD-PABA during the prenatal, lactation, and early infancy periods on pubertal development and thyroid function in male and female rats. The thyroid glands, uteri, testes, prostate glands, and seminal vesicles were excised and weighed, the reproductive organs were analyzed histologically, and the serum hormone levels were measured. In the prenatal period, the thyroxine (T4) levels increased in the female rats in the exposed groups ( p < 0...
October 2017: Toxicology and Industrial Health
Anders Rehfeld, Dorte Egeberg, Kristian Almstrup, Jørgen Holm Petersen, Steen Dissing, Niels Erik Skakkebæk
Human sperm cell function must be precisely regulated to achieve natural fertilization. Progesterone released by the cumulus cells surrounding the egg induces a Ca2+-influx into human sperm cells via the CatSper Ca2+-channel and thereby controls sperm function. Multiple chemical UV filters have been shown to induce a Ca2+-influx through CatSper, thus mimicking the effect of progesterone on Ca2+-signaling. We hypothesized that these UV filters could also mimic the effect of progesterone on sperm function. We examined 29 UV filters allowed in sunscreens in the US and/or EU for their ability to affect acrosome reaction, penetration, hyperactivation, and viability in human sperm cells...
September 5, 2017: Endocrine Connections
Wesam R Kadhum, Tomoki Hada, Ichiro Hijikuro, Hiroaki Todo, Kenji Sugibayashi
Liquid crystal (LC)-forming lipids represent an important class of biocompatible amphiphiles and their application extends to cosmeceutical, dietary, and pharmaceutical technologies. In the present study, we aimed to develop strategies for designing and optimizing oral and topical LC formulations by evaluating their in vitro and in vivo drug absorption performances. C17-Monoglycerol ester (MGE) was used as a LC-forming lipid. p-Amino benzoic acid, methyl PABA, ethyl PABA, and sodium fluorescein were selected as drug models with different physiochemical properties...
2017: Journal of Oleo Science
Paul G Richardson, Shaji Kumar, Jacob P Laubach, Claudia Paba-Prada, Neeraj Gupta, Deborah Berg, Helgi van de Velde, Philippe Moreau
Ixazomib is the first oral proteasome inhibitor to be approved, in combination with lenalidomide and dexamethasone, for the treatment of patients with multiple myeloma who have received at least one prior therapy. Approval was on the basis of results from the phase 3, double-blind, placebo-controlled TOURMALINE-MM1 study, which demonstrated a 35% improvement in progression-free survival with the all-oral combination of ixazomib plus lenalidomide-dexamethasone versus lenalidomide-dexamethasone alone (median: 20...
2017: Journal of Blood Medicine
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