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https://www.readbyqxmd.com/read/29745344/selection-of-g1-paba-as-a-gper1-ligand-compared-to-phenol-red-via-a-ligand-based-virtual-screening-coupled-to-molecular-dynamics-simulations-and-its-anti-proliferative-effects-on-breast-cancer-cells
#1
Correa-Basurto Jose, Jose G Trujillo-Ferrara, Mendoza-Lujambio Irene, Duenas-Gonzalez Alfonso, Chavez-Blanco Alma, Martinez-Archundia Marlet, M Bello, Garcia Sanchez Jose Ruben, Fragoso-Vazquez Manuel Jonathan, Mendez-Luna David, Prestegui-Martel Berenice, Martinez-Munoz Alberto
Recent reports have demonstrated the role of the G protein-coupled estrogen receptor (GPER1) on the growth and proliferation of breast cancer cells. The coupling of GPER1 to estrogen, tamoxifen or fulvestrant triggers cellular signaling pathways (PI3K and ERK) related to cell proliferation. In an effort to develop new therapeutic strategies against breast cancer, we performed an in silico study to explore the binding pose of a set of designed G15 and G1 analogue compounds, including phenol red. First, we included a carboxyl group instead of the acetyl group from G1 to form amides with several moieties to increase the affinity for GPER1...
May 10, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29743855/design-synthesis-characterization-and-computational-docking-studies-of-novel-sulfonamide-derivatives
#2
Hira Saleem, Arooma Maryam, Saleem Ahmed Bokhari, Ayesha Ashiq, Sadaf Abdul Rauf, Rana Rehan Khalid, Fahim Ashraf Qureshi, Abdul Rauf Siddiqi
This study reports three novel sulfonamide derivatives 4-Chloro-N-[(4-methylphenyl) sulphonyl]-N-propyl benzamide ( 1A ), N-(2-hydroxyphenyl)-4-methyl benzene sulfonamide ( 1B ) and 4-methyl-N-(2-nitrophenyl) benzene sulfonamide ( 1C ). The compounds were synthesised from starting material 4-methylbenzenesulfonyl chloride and their structure was studied through 1 H-NMR and 13 C-NMR spectra. Computational docking was performed to estimate their binding energy against bacterial p -amino benzoic acid (PABA) receptor, the dihydropteroate synthase (DHPS)...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29740809/a-phase-2-study-of-modified-lenalidomide-bortezomib-and-dexamethasone-in-transplant-ineligible-multiple-myeloma
#3
Elizabeth K O'Donnell, Jacob P Laubach, Andrew J Yee, Tianqi Chen, Carol Ann Huff, Frank G Basile, Philip M Wade, Claudia E Paba-Prada, Irene M Ghobrial, Robert L Schlossman, Jill N Burke, Cynthia C Harrington, Kathleen J Lively, Hannah F Lyons, Nikhil C Munshi, Kenneth C Anderson, Lorenzo Trippa, Paul G Richardson, Noopur S Raje
We sought a regimen that incorporates optimal novel agents and balances efficacy with toxicity in transplant-ineligible multiple myeloma (MM) patients. Our study evaluated modified lenalidomide-bortezomib-dexamethasone (RVD lite) in this population and was administered over a 35-day cycle. Lenalidomide 15 mg was given orally on days 1-21; bortezomib 1·3 mg/m2 weekly subcutaneously on days 1, 8, 15 and 22; and dexamethasone 20 mg orally was given on the day of and day after bortezomib for 9 cycles followed by 6 cycles of consolidation with lenalidomide and bortezomib...
May 8, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29712422/-11-c-para-aminobenzoic-acid-a-positron-emission-tomography-tracer-targeting-bacteria-specific-metabolism
#4
Christopher A Mutch, Alvaro A Ordonez, Hecong Qin, Matthew Parker, Lauren E Bambarger, Javier E Villanueva-Meyer, Joseph Blecha, Valerie Carroll, Celine Taglang, Robert Flavell, Renuka Sriram, Henry VanBrocklin, Oren Rosenberg, Michael A Ohliger, Sanjay K Jain, Kiel D Neumann, David M Wilson
Imaging studies are frequently used to support the clinical diagnosis of infection. These techniques include computed tomography (CT) and magnetic resonance imaging (MRI) for structural information and single photon emission computed tomography (SPECT) or positron emission tomography (PET) for metabolic data. However, frequently, there is significant overlap in the imaging appearance of infectious and noninfectious entities using these tools. To address this concern, recent approaches have targeted bacteria-specific metabolic pathways...
May 8, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29545186/cytomegalovirus-and-epstein-barr-virus-dna-kinetics-in-whole-blood-and-plasma-of-allogeneic-hematopoietic-stem-cell-transplantation-recipients
#5
Tiziana Lazzarotto, Angela Chiereghin, Antonio Piralla, Giulia Piccirilli, Alessia Girello, Giulia Campanini, Liliana Gabrielli, Cristina Costa, Arcangelo Prete, Francesca Bonifazi, Alessandro Busca, Roberto Cairoli, Anna Amelia Colombo, Marco Zecca, Francesca Sidoti, Gabriele Bianco, Pierpaolo Paba, Carlo Federico Perno, Rossana Cavallo, Fausto Baldanti
Currently, no consensus has been reached on the optimal blood compartment to be used for surveillance of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) DNAemia. Although several comparative studies have been performed correlating CMV and EBV DNA loads in whole blood (WB) versus plasma, to our knowledge, no studies to date have analyzed the kinetics of both viruses in the 2 blood compartments. In this retrospective noninterventional multicenter cohort study, the kinetics of CMV and EBV DNA in 121 hematopoietic stem cell transplantation (HSCT) recipients were investigated by analyzing in parallel 569 and 351 paired samples from 80 and 58 sequential episodes of CMV and EBV DNAemia, respectively...
March 12, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29461819/enhanced-arylamine-n-oxygenase-activity-of-polymer-enzyme-assemblies-by-facilitating-electron-transferring-efficiency
#6
Libo Zhang, Yanmei Xu, Thomas M Makris, Qian Wang
A novel N-oxygenase-coated core-shell nanoparticle was generated through the coassembly of poly(4-vinylpyridine) (P4VP) and arylamine N-oxygenase CmlI. The resulting enzyme-hybridized particles, P4VP-CmlI, showed excellent catalytic activities on the oxidation of two arylamine substrates, i.e., p-aminophenol ( pAP) and p-aminobenzoic acid ( pABA), using a surrogate redox system or a peroxide shunt as co-oxidants. In comparison with the free enzyme, P4VP-CmlI particles exhibited a significantly enhanced catalytic efficiency when using pyridine nucleotide (NADH) and proper redox mediators...
March 12, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29448230/reversible-modulation-of-the-redox-activity-in-conducting-polymer-nanofilms-induced-by-hydrophobic-collapse-of-a-surface-grafted-polyelectrolyte
#7
Gonzalo E Fenoy, Juan M Giussi, Catalina von Bilderling, Eliana M Maza, Lía I Pietrasanta, Wolfgang Knoll, Waldemar A Marmisollé, Omar Azzaroni
We present the covalent modification of a Pani-like conducting polymer (polyaminobenzylamine, PABA) by grafting of a polyelectrolyte brush (poly [2-(methacryloyloxy)-ethyl-trimethylammonium chloride], PMETAC). As PABA has extra pendant amino moieties, the grafting procedure does not affect the backbone nitrogen atoms that are implicated in the electronic structure of the conducting polymers. Moreover, perchlorate anions interact very strongly with the quaternary ammonium pendant groups of PMETAC through ion pairing...
May 15, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29398075/assessment-of-second-i-2m-and-third-i-3m-molar-indices-for-establishing-14-and-16-legal-ages-and-validation-of-the-cameriere-s-i-3m-cut-off-for-18-years-old-in-chilean-population
#8
Roberto Cameriere, Luz Andrea Velandia Palacio, Jorge Pinares, Fiorella Bestetti, Rossella Paba, Erminia Coccia, Luigi Ferrante
This retrospective cross-sectional study has two-fold aims: the first is to assess new cut-offs at the legal age thresholds (LATs) of 14 and 16 years old and the second is to validate the cut-off of third molar index I3M =0.08 for 18 years of age in Chilean people. Orthopantomographs from 822 Chilean children aged from 11 to 22 (472 girls and 350 boys) were analysed. For LAT of 14 years, cut-offs were found using the ROC curves singly for boys and girls. The cut-offs for boys were I2M =0.16 and I3M =0.73 while for girls we obtained I2M =0...
April 2018: Forensic Science International
https://www.readbyqxmd.com/read/29357800/anti-inflammatory-activity-and-cheminformatics-analysis-of-new-poten-t-2-substituted-1-methyl-5-nitroindazolinones
#9
REVIEW
Dany Siverio-Mota, Isabel Andujar, Yovani Marrero-Ponce, Rosa M Giner, Claudia Diaz-Mendoza, Ganiveth Manjarrez Paba, Liliana Vicet-Muro, Maria Lorena Cordero-Maldonado, Peter A M de Witte, Alexander D Crawford, Maite Sylla-Iyarreta Veitia, Facundo Perez-Jimenez, Vicente J Aran
After the identification of the anti-inflammatory properties of VA5-13l (2-benzyl-1- methyl-5-nitroindazolinone) in previous investigations, some of its analogous compounds were designed, synthesized and evaluated in two anti-inflammatory methods: LPS-enhanced leukocyte migration assay in zebrafish; and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema. The products evaluated (3, 6, 8, 9 and 10) showed the lower values of relative leukocyte migration at 30 µM (0.14, 0.07, 0.10, 0.13 and 0...
February 9, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29283262/production-of-antifungal-p-aminobenzoic-acid-in-lysobacter-antibioticus-oh13
#10
Pedro Laborda, Yangyang Zhao, Jun Ling, Rongxian Hou, Fengquan Liu
Among Lysobacter species, Lysobacter antibioticus has been demonstrated to be an interesting source of antimicrobial metabolites for the biocontrol of plant diseases. Although the antibacterial activity was attributed to N-oxide phenazines, the active compounds involved in the antifungal function remained unknown. In this work, an antifungal compound was isolated and identified as p-aminobenzoic acid (pABA). Antifungal activity screening revealed that pABA shows activity against a number of plant pathogens...
January 24, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29275262/design-synthesis-antibacterial-evaluation-and-molecular-docking-studies-of-some-new-quinoxaline-derivatives-targeting-dihyropteroate-synthase-enzyme
#11
Maryam A Z El-Attar, Rasha Y Elbayaa, Omaima G Shaaban, Nargues S Habib, Abeer E Abdel Wahab, Ibrahim A Abdelwahab, Soad A M El-Hawash
Development of new antimicrobial agents is a good solution to overcome drug-resistance problems. From this perspective, new quinoxaline derivatives bearing various bioactive heterocyclic moieties (thiadiazoles, oxadiazoles, pyrazoles and thiazoles) were designed and synthesized. The newly synthesized compounds were evaluated for their in vitro antibacterial activity against nine bacterial human pathogenic strains using the disc diffusion assay. In general, most of the synthesized compounds exhibited good antibacterial activities...
February 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29188033/simple-methods-to-reduce-major-allergens-ara-h-1-and-ana-o-1-2-in-peanut-and-cashew-extracts
#12
Si-Yin Chung, Christopher P Mattison, Casey C Grimm, Shawndrika Reed
Whole peanut or cashew extracts are usually used in immunotherapy. Reducing major allergen(s) in the extracts may lessen their side effects. Three methods were evaluated to reduce major allergens in peanut extracts: (1) p -aminobenzamidine; (2) magnetic agarose beads; and (3) extraction of a commercial peanut flour at pH 7, respectively. The first two methods were also used to reduce major allergens in cashew extracts. After treatments, samples were evaluated by SDS-PAGE. pABA-treated samples were also analyzed for IgE binding in western blot...
November 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/29171692/8-mercaptoguanine-derivatives-as-inhibitors-of-dihydropteroate-synthase
#13
Matthew L Dennis, Michael D Lee, Jitendra R Harjani, Mohamed Ahmed, Aaron J DeBono, Noel P Pitcher, Zhong-Chang Wang, Sandeep Chhabra, Nicholas Barlow, Raphaël Rahmani, Ben Cleary, Olan Dolezal, Meghan Hattarki, Luigi Aurelio, Jeremy Shonberg, Bim Graham, Thomas S Peat, Jonathan B Baell, James D Swarbrick
Dihydropteroate synthase (DHPS) is an enzyme of the folate biosynthesis pathway, which catalyzes the formation of 7,8-dihydropteroate (DHPt) from 6-hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPPP) and para-aminobenzoic acid (pABA). DHPS is the long-standing target of the sulfonamide class of antibiotics that compete with pABA. In the wake of sulfa drug resistance, targeting the structurally rigid (and more conserved) pterin site has been proposed as an alternate strategy to inhibit DHPS in wild-type and sulfa drug resistant strains...
February 6, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29046667/nanopore-long-read-guided-complete-genome-assembly-of-hydrogenophaga-intermedia-and-genomic-insights-into-4-aminobenzenesulfonate-p-aminobenzoic-acid-and-hydrogen-metabolism-in-the-genus-hydrogenophaga
#14
Han M Gan, Yin P Lee, Christopher M Austin
We improved upon the previously reported draft genome of Hydrogenophaga intermedia strain PBC, a 4-aminobenzenesulfonate-degrading bacterium, by supplementing the assembly with Nanopore long reads which enabled the reconstruction of the genome as a single contig. From the complete genome, major genes responsible for the catabolism of 4-aminobenzenesulfonate in strain PBC are clustered in two distinct genomic regions. Although the catabolic genes for 4-sulfocatechol, the deaminated product of 4-aminobenzenesulfonate, are only found in H...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29046490/exposure-to-airborne-endotoxin-in-italian-greenhouses-environmental-analyses
#15
Angela Gioffrè, Antonella Marramao, Ignazio DI Gesu, Pasquale Samele, Emilia Paba, Anna Marcelloni, Alessandra Chiominto, Sergio Iavicoli
The peculiar characteristics of the greenhouses as confined spaces, microclimate and poor air exchange with the outside environment, encourage the development of a large number of biological agents. Endotoxin, is probably a major causative agent of occupational health problems. The objective of this study was to measure the concentrations of airborne endotoxin in greenhouses with different cultures. The influence of microclimate was studied in correlation with endotoxin levels and type of cultured vegetables...
October 19, 2017: Industrial Health
https://www.readbyqxmd.com/read/29043425/arylamine-n-acetyltransferase-1-in-situ-n-acetylation-on-cd3-peripheral-blood-mononuclear-cells-correlate-with-natb-mrna-and-nat1-haplotype
#16
Raúl A Salazar-González, Eneida Turiján-Espinoza, David W Hein, Perla C Niño-Moreno, Silvia Romano-Moreno, Rosa C Milán-Segovia, Diana P Portales-Pérez
Human arylamine N-acetyltransferase 1 (NAT1) is responsible for the activation and elimination of xenobiotic compounds and carcinogens. Genetic polymorphisms in NAT1 modify both drug efficacy and toxicity. Previous studies have suggested a role for NAT1 in the development of several diseases. The aim of the present study was to evaluate NAT1 protein expression and in situ N-acetylation capacity in peripheral blood mononuclear cells (PBMC), as well as their possible associations with the expression of NAT1 transcript and NAT1 genotype...
February 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/28992479/bioaccumulation-of-uv-filters-in-mytilus-galloprovincialis-mussel
#17
Leticia Vidal-Liñán, Eugenia Villaverde-de-Sáa, Rosario Rodil, José Benito Quintana, Ricardo Beiras
In this study the bioaccumulation kinetics of organic UV filters, such as 4-MBC, BP-3, BP-4, OC and OD-PABA in wild Mytilus galloprovincialis mussels was investigated. The uptake and accumulation of waterborne 4-MBC, BP-4 and OC was very rapid, and after only 24 h of exposure to 1 μg L-1 , the tissular concentrations were 418, 263 and 327 μg kg-1 d.w., respectively. The kinetics of bioaccumulation of BP-4 and OC significantly fitted to an asymptotic model with BCF values of 905 L kg-1 and 2210 L kg-1 , respectively...
January 2018: Chemosphere
https://www.readbyqxmd.com/read/28949807/pesticide-dispersion-by-spraying-under-tropical-conditions
#18
Tomaz Langenbach, Denise Mano, Maize M Campos, Alessandra L M C Cunha, Tácio M P De Campos
Pesticide air pollution by spraying was evaluated under different temperature, humidity and wind climatic conditions in Brazil. Field experiments were performed with application towards the soil and in guava orchards, where spray dispersion was monitored by adding p-aminobenzoic acid (PABA), a fluorescent substance, as a tracer to the water contained in the spray tanks. Samples were collected with filter membranes (Whatman 180025), and the PABA was extracted from the filters by shaking with water in a Petri dish and measured in a spectrofluorometer...
December 2, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/28924191/metabolic-crosstalk-regulates-porphyromonas-gingivalis-colonization-and-virulence-during-oral-polymicrobial-infection
#19
Masae Kuboniwa, John R Houser, Erik L Hendrickson, Qian Wang, Samar A Alghamdi, Akito Sakanaka, Daniel P Miller, Justin A Hutcherson, Tiansong Wang, David A C Beck, Marvin Whiteley, Atsuo Amano, Huizhi Wang, Edward M Marcotte, Murray Hackett, Richard J Lamont
Many human infections are polymicrobial in origin, and interactions among community inhabitants shape colonization patterns and pathogenic potential1 . Periodontitis, which is the sixth most prevalent infectious disease worldwide2 , ensues from the action of dysbiotic polymicrobial communities3 . The keystone pathogen Porphyromonas gingivalis and the accessory pathogen Streptococcus gordonii interact to form communities in vitro and exhibit increased fitness in vivo3,4 . The mechanistic basis of this polymicrobial synergy, however, has not been fully elucidated...
November 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28886459/inner-filter-with-carbon-quantum-dots-a-selective-sensing-platform-for-detection-of-hematin-in-human-red-cells
#20
Qian Qian Zhang, Bin Bin Chen, Hong Yan Zou, Yuan Fang Li, Cheng Zhi Huang
Hematin plays a crucial role in various physiological functions, and the determination of hematin in complex biological matrixes is a significant but difficult issue. Considering the unique photophysical/photochemical properties of carbon quantum dots (CQDs) prepared with p-aminobenzoic acid (PABA) and ethanol, a new strategy for the design of fluorescent probes for hematin has been achieved. The proposed sensor array is fabricated based on the inner filter effect (IFE) between hematin and CQDs with phenomenon of selective fluorescence quenching of CQDs which results from the strong absorption of the excitation and emission spectrum of CQDs by hematin...
August 24, 2017: Biosensors & Bioelectronics
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