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https://www.readbyqxmd.com/read/29283262/production-of-antifungal-p-aminobenzoic-acid-in-lysobacter-antibioticus-oh13
#1
Pedro Laborda, Yangyang Zhao, Jun Ling, Rongxian Hou, Fengquan Liu
Among Lysobacter species, Lysobacter antibioticus has been demonstrated to be an interesting source of antimicrobial metabolites for the biocontrol of plant diseases. Although the antibacterial activity was attributed to N-oxide phenazines, the active compounds involved in the antifungal function remained unknown. In this work, an antifungal compound has been isolated and identified as p-aminobenzoic acid (pABA). Antifungal activity screening revealed that pABA shows activity against a number of plant pathogens...
December 28, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29275262/design-synthesis-antibacterial-evaluation-and-molecular-docking-studies-of-some-new-quinoxaline-derivatives-targeting-dihyropteroate-synthase-enzyme
#2
Maryam A Z El-Attar, Rasha Y Elbayaa, Omaima G Shaaban, Nargues S Habib, Abeer E Abdel Wahab, Ibrahim A Abdelwahab, Soad A M El-Hawash
Development of new antimicrobial agents is a good solution to overcome drug-resistance problems. From this perspective, new quinoxaline derivatives bearing various bioactive heterocyclic moieties (thiadiazoles, oxadiazoles, pyrazoles and thiazoles) were designed and synthesized. The newly synthesized compounds were evaluated for their in vitro antibacterial activity against nine bacterial human pathogenic strains using the disc diffusion assay. In general, most of the synthesized compounds exhibited good antibacterial activities...
December 5, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29188033/simple-methods-to-reduce-major-allergens-ara-h-1-and-ana-o-1-2-in-peanut-and-cashew-extracts
#3
Si-Yin Chung, Christopher P Mattison, Casey C Grimm, Shawndrika Reed
Whole peanut or cashew extracts are usually used in immunotherapy. Reducing major allergen(s) in the extracts may lessen their side effects. Three methods were evaluated to reduce major allergens in peanut extracts: (1) p-aminobenzamidine; (2) magnetic agarose beads; and (3) extraction of a commercial peanut flour at pH 7, respectively. The first two methods were also used to reduce major allergens in cashew extracts. After treatments, samples were evaluated by SDS-PAGE. pABA-treated samples were also analyzed for IgE binding in western blot...
November 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/29171692/8-mercaptoguanine-derivatives-as-inhibitors-of-dihydropteroate-synthase
#4
James Swarbrick, Matthew Dennis, Michael Lee, Jitendra Harjani, Mohamed Ahmed, Aaron Debono, Noel Pitcher, Zhong-Chang Wang, Sandeep Chhabra, Nicholas Barlow, Raphael Rahmani, Ben Cleary, Olan Dolezal, Meghan Hattarki, Luigi Aurelio, Jeremy Shonberg, Bim Graham, Tom Peat, Jonathan Baell
Dihydropteroate synthase (DHPS) is an enzyme of the folate biosynthesis pathway which catalyzes the formation of 7,8-dihydropteroate (DHPt) from 6-hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPPP) and para-aminobenzoic acid (pABA). DHPS is the long-standing target of the sulfonamide class of antibiotics that compete with pABA. In the wake of sulfa drug resistance, targeting the structurally rigid (and more conserved) pterin site has been proposed as an alternate strategy to inhibit DHPS in wild-type and sulfa drug resistant strains...
November 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29046667/nanopore-long-read-guided-complete-genome-assembly-of-hydrogenophaga-intermedia-and-genomic-insights-into-4-aminobenzenesulfonate-p-aminobenzoic-acid-and-hydrogen-metabolism-in-the-genus-hydrogenophaga
#5
Han M Gan, Yin P Lee, Christopher M Austin
We improved upon the previously reported draft genome of Hydrogenophaga intermedia strain PBC, a 4-aminobenzenesulfonate-degrading bacterium, by supplementing the assembly with Nanopore long reads which enabled the reconstruction of the genome as a single contig. From the complete genome, major genes responsible for the catabolism of 4-aminobenzenesulfonate in strain PBC are clustered in two distinct genomic regions. Although the catabolic genes for 4-sulfocatechol, the deaminated product of 4-aminobenzenesulfonate, are only found in H...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29046490/exposure-to-airborne-endotoxin-in-italian-greenhouses-environmental-analyses
#6
Angela Gioffrè, Antonella Marramao, Ignazio DI Gesu, Pasquale Samele, Emilia Paba, Anna Marcelloni, Alessandra Chiominto, Sergio Iavicoli
The peculiar characteristics of the greenhouses as confined spaces, microclimate and poor air exchange with the outside environment, encourage the development of a large number of biological agents. Endotoxin, is probably a major causative agent of occupational health problems. The objective of this study was to measure the concentrations of airborne endotoxin in greenhouses with different cultures. The influence of microclimate was studied in correlation with endotoxin levels and type of cultured vegetables...
October 19, 2017: Industrial Health
https://www.readbyqxmd.com/read/29043425/arylamine-n-acetyltransferase-1-in-situ-n-acetylation-on-cd3-peripheral-blood-mononuclear-cells-correlate-with-natb-mrna-and-nat1-haplotype
#7
Raúl A Salazar-González, Eneida Turiján-Espinoza, David W Hein, Perla C Niño-Moreno, Silvia Romano-Moreno, Rosa C Milán-Segovia, Diana P Portales-Pérez
Human arylamine N-acetyltransferase 1 (NAT1) is responsible for the activation and elimination of xenobiotic compounds and carcinogens. Genetic polymorphisms in NAT1 modify both drug efficacy and toxicity. Previous studies have suggested a role for NAT1 in the development of several diseases. The aim of the present study was to evaluate NAT1 protein expression and in situ N-acetylation capacity in peripheral blood mononuclear cells (PBMC), as well as their possible associations with the expression of NAT1 transcript and NAT1 genotype...
October 17, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28992479/bioaccumulation-of-uv-filters-in-mytilus-galloprovincialis-mussel
#8
Leticia Vidal-Liñán, Eugenia Villaverde-de-Sáa, Rosario Rodil, José Benito Quintana, Ricardo Beiras
In this study the bioaccumulation kinetics of organic UV filters, such as 4-MBC, BP-3, BP-4, OC and OD-PABA in wild Mytilus galloprovincialis mussels was investigated. The uptake and accumulation of waterborne 4-MBC, BP-4 and OC was very rapid, and after only 24 h of exposure to 1 μg L(-1), the tissular concentrations were 418, 263 and 327 μg kg(-1)d.w., respectively. The kinetics of bioaccumulation of BP-4 and OC significantly fitted to an asymptotic model with BCF values of 905 L kg(-1) and 2210 L kg(-1), respectively...
September 29, 2017: Chemosphere
https://www.readbyqxmd.com/read/28949807/pesticide-dispersion-by-spraying-under-tropical-conditions
#9
Tomaz Langenbach, Denise Mano, Maize M Campos, Alessandra L M C Cunha, Tácio M P De Campos
Pesticide air pollution by spraying was evaluated under different temperature, humidity and wind climatic conditions in Brazil. Field experiments were performed with application towards the soil and in guava orchards, where spray dispersion was monitored by adding p-aminobenzoic acid (PABA), a fluorescent substance, as a tracer to the water contained in the spray tanks. Samples were collected with filter membranes (Whatman 180025), and the PABA was extracted from the filters by shaking with water in a Petri dish and measured in a spectrofluorometer...
September 26, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/28924191/metabolic-crosstalk-regulates-porphyromonas-gingivalis-colonization-and-virulence-during-oral-polymicrobial-infection
#10
Masae Kuboniwa, John R Houser, Erik L Hendrickson, Qian Wang, Samar A Alghamdi, Akito Sakanaka, Daniel P Miller, Justin A Hutcherson, Tiansong Wang, David A C Beck, Marvin Whiteley, Atsuo Amano, Huizhi Wang, Edward M Marcotte, Murray Hackett, Richard J Lamont
Many human infections are polymicrobial in origin, and interactions among community inhabitants shape colonization patterns and pathogenic potential (1) . Periodontitis, which is the sixth most prevalent infectious disease worldwide (2) , ensues from the action of dysbiotic polymicrobial communities (3) . The keystone pathogen Porphyromonas gingivalis and the accessory pathogen Streptococcus gordonii interact to form communities in vitro and exhibit increased fitness in vivo (3,4) . The mechanistic basis of this polymicrobial synergy, however, has not been fully elucidated...
November 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28886459/inner-filter-with-carbon-quantum-dots-a-selective-sensing-platform-for-detection-of-hematin-in-human-red-cells
#11
Qian Qian Zhang, Bin Bin Chen, Hong Yan Zou, Yuan Fang Li, Cheng Zhi Huang
Hematin plays a crucial role in various physiological functions, and the determination of hematin in complex biological matrixes is a significant but difficult issue. Considering the unique photophysical/photochemical properties of carbon quantum dots (CQDs) prepared with p-aminobenzoic acid (PABA) and ethanol, a new strategy for the design of fluorescent probes for hematin has been achieved. The proposed sensor array is fabricated based on the inner filter effect (IFE) between hematin and CQDs with phenomenon of selective fluorescence quenching of CQDs which results from the strong absorption of the excitation and emission spectrum of CQDs by hematin...
August 24, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28879804/evaluation-of-the-endocrine-disrupting-effects-of-homosalate-hms-and-2-ethylhexyl-4-dimethylaminobenzoate-od-paba-in-rat-pups-during-the-prenatal-lactation-and-early-postnatal-periods
#12
Meltem Erol, Ismet Çok, Özlem Bostan Gayret, Pembegül Günes, Özgül Yigit, Elif Sayman, Aysegül Günes, Duygu Sultan Çelik, Sahin Hamilçikan, Serdar Altinay, Oya Ercan
Homosalate (HMS) and 2-ethylhexyl 4-dimethylaminobenzoate (OD-PABA) are ultraviolet filters. We aimed to investigate the effects of dermal exposure to HMS and OD-PABA during the prenatal, lactation, and early infancy periods on pubertal development and thyroid function in male and female rats. The thyroid glands, uteri, testes, prostate glands, and seminal vesicles were excised and weighed, the reproductive organs were analyzed histologically, and the serum hormone levels were measured. In the prenatal period, the thyroxine (T4) levels increased in the female rats in the exposed groups ( p < 0...
October 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28874401/chemical-uv-filters-can-affect-human-sperm-function-in-a-progesterone-like-manner
#13
Anders Rehfeld, Dorte Egeberg, Kristian Almstrup, Jørgen Holm Petersen, Steen Dissing, Niels Erik Skakkebæk
Human sperm cell function must be precisely regulated to achieve natural fertilization. Progesterone released by the cumulus cells surrounding the egg induces a Ca2+-influx into human sperm cells via the CatSper Ca2+-channel and thereby controls sperm function. Multiple chemical UV filters have been shown to induce a Ca2+-influx through CatSper, thus mimicking the effect of progesterone on Ca2+-signaling. We hypothesized that these UV filters could also mimic the effect of progesterone on sperm function. We examined 29 UV filters allowed in sunscreens in the US and/or EU for their ability to affect acrosome reaction, penetration, hyperactivation, and viability in human sperm cells...
September 5, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28867759/development-and-optimization-of-orally-and-topically-applied-liquid-crystal-drug-formulations
#14
Wesam R Kadhum, Tomoki Hada, Ichiro Hijikuro, Hiroaki Todo, Kenji Sugibayashi
Liquid crystal (LC)-forming lipids represent an important class of biocompatible amphiphiles and their application extends to cosmeceutical, dietary, and pharmaceutical technologies. In the present study, we aimed to develop strategies for designing and optimizing oral and topical LC formulations by evaluating their in vitro and in vivo drug absorption performances. C17-Monoglycerol ester (MGE) was used as a LC-forming lipid. p-Amino benzoic acid, methyl PABA, ethyl PABA, and sodium fluorescein were selected as drug models with different physiochemical properties...
2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28860887/new-developments-in-the-management-of-relapsed-refractory-multiple-myeloma-the-role-of-ixazomib
#15
REVIEW
Paul G Richardson, Shaji Kumar, Jacob P Laubach, Claudia Paba-Prada, Neeraj Gupta, Deborah Berg, Helgi van de Velde, Philippe Moreau
Ixazomib is the first oral proteasome inhibitor to be approved, in combination with lenalidomide and dexamethasone, for the treatment of patients with multiple myeloma who have received at least one prior therapy. Approval was on the basis of results from the phase 3, double-blind, placebo-controlled TOURMALINE-MM1 study, which demonstrated a 35% improvement in progression-free survival with the all-oral combination of ixazomib plus lenalidomide-dexamethasone versus lenalidomide-dexamethasone alone (median: 20...
2017: Journal of Blood Medicine
https://www.readbyqxmd.com/read/28856664/iga-multiple-myeloma-in-a-patient-with-an-igg-pemphigus-foliaceus-like-exanthem
#16
Nayoung Lee, Stephen J Lockwood, Paul Richardson, Claudia Paba-Prada, Arturo P Saavedra
No abstract text is available yet for this article.
October 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28808156/identification-of-staphylococcus-aureus-factors-required-for-pathogenicity-and-growth-in-human-blood
#17
John Connolly, Emma Boldock, Lynne R Prince, Stephen A Renshaw, Moira K Whyte, Simon J Foster
Staphylococcus aureus is a human commensal but also has devastating potential as an opportunistic pathogen. S. aureus bacteremia is often associated with an adverse outcome. To identify potential targets for novel control approaches, we have identified S. aureus components that are required for growth in human blood. An ordered transposon mutant library was screened, and 9 genes involved specifically in hemolysis or growth on human blood agar were identified by comparing the mutants to the parental strain. Three genes (purA, purB, and pabA) were subsequently found to be required for pathogenesis in the zebrafish embryo infection model...
November 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28805228/highly-dispersed-tio2-nanoparticles-with-abundant-active-sites-induced-by-surfactants-as-a-prominent-substrate-for-sers-charge-transfer-contribution
#18
Libin Yang, Di Yin, Yu Shen, Ming Yang, Xiuling Li, Xiaoxia Han, Xin Jiang, Bing Zhao
In this study, highly-dispersed TiO2 nanoparticles (NPs) with abundant active sites were synthesized by a simple sol-hydrothermal method with the assistance of surfactant polyethylene glycol (PEG) which served as an effective SERS-active substrate for the first time. The observed considerable SERS enhancement of 4-mercaptobenzoic acid (4-MBA) probe molecules on TiO2 NPs is attributed to the contribution of the charge transfer mechanism from the substrate to the probe molecule. It is suggested that PEG can act as a protective agent in the reductive calcination of the surfactant-coated nanocrystallite and consequently brings about abundant surface oxygen vacancies for TiO2 NPs, which provide more effective sites for the adsorption of probe molecules and promote the charge transfer effect and its consequent SERS enhancement...
August 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28747479/a-nutrient-mediates-intraspecific-competition-between-rodent-malaria-parasites-in-vivo
#19
Nina Wale, Derek G Sim, Andrew F Read
Hosts are often infected with multiple strains of a single parasite species. Within-host competition between parasite strains can be intense and has implications for the evolution of traits that impact patient health, such as drug resistance and virulence. Yet the mechanistic basis of within-host competition is poorly understood. Here, we demonstrate that a parasite nutrient, para-aminobenzoic acid (pABA), mediates competition between a drug resistant and drug susceptible strain of the malaria parasite, Plasmodium chabaudi We further show that increasing pABA supply to hosts infected with the resistant strain worsens disease and changes the relationship between parasite burden and pathology...
July 26, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28736527/human-coq9-rescues-a-coq9-yeast-mutant-by-enhancing-coenzyme-q-biosynthesis-from-4-hydroxybenzoic-acid-and-stabilizing-the-coq-synthome
#20
Cuiwen H He, Dylan S Black, Christopher M Allan, Brigitte Meunier, Shamima Rahman, Catherine F Clarke
Coq9 is required for the stability of a mitochondrial multi-subunit complex, termed the CoQ-synthome, and the deamination step of Q intermediates that derive from para-aminobenzoic acid (pABA) in yeast. In human, mutations in the COQ9 gene cause neonatal-onset primary Q10 deficiency. In this study, we determined whether expression of human COQ9 could complement yeast coq9 point or null mutants. We found that expression of human COQ9 rescues the growth of the temperature-sensitive yeast mutant, coq9-ts19, on a non-fermentable carbon source and increases the content of Q6, by enhancing Q biosynthesis from 4-hydroxybenzoic acid (4HB)...
2017: Frontiers in Physiology
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