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https://www.readbyqxmd.com/read/29790450/opisthotonos-and-unilateral-internal-hydrocephalus-associated-with-aberrant-migration-of-serratospiculum-sp-or-serratospiculoides-sp-in-a-prairie-falcon
#1
Arnaud J Van Wettere, Jaqueline P Kurz, Amanda Wilhelm, Jay Dee Ipsen
A juvenile, wild-caught prairie falcon ( Falco mexicanus) kept for falconry was presented to a veterinary hospital for intermittent opisthotonos and torticollis. Clinical examination, complete blood count, serum biochemistry panel, and fecal analysis were unremarkable. Clinical signs did not resolve, and the bird was euthanized 6 mo after the appearance of clinical signs. Autopsy revealed a mild, unilateral hydrocephalus and nematodes within the thoracic air sac. Histopathology demonstrated mild, unilateral hydrocephalus; scattered glial nodules; meningeal nematode sections; and meningeal and intraventricular embryonated eggs...
May 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29745254/treatment-of-rat-congenital-diaphragmatic-hernia-with-sildenafil-and-ns-304-selexipag-s-active-compound-at-the-pseudoglandular-stage-improves-lung-vasculature
#2
Daphne S Mous, Heleen M Kool, Petra E Burgisser, Marjon J Buscop-van Kempen, Koji Nagata, Anne Boerema-de Munck, Joost van Rosmalen, Oleh Dzyubachyk, Rene Mh Wijnen, Dick Tibboel, Robbert J Rottier
Patients with congenital diaphragmatic hernia (CDH) often suffer from severe pulmonary hypertension and the choice of current vasodilator therapy is mostly based on trial and error. Since pulmonary vascular abnormalities are already present early during development, we performed a study to modulate these pulmonary vascular changes at an early stage during gestation. Pregnant Sprague-Dawley rats were treated with nitrofen at day 9.5 of gestation (E9.5) to induce CDH in the offspring and subsequently the phosphodiesterase-5 inhibitor sildenafil and/or the novel prostaglandin-I receptor agonist selexipag (NS-304) were administered from E17...
May 10, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29719527/vestibular-evoked-myogenic-potentials-in-bilateral-vestibulopathy
#3
REVIEW
Sally M Rosengren, Miriam S Welgampola, Rachael L Taylor
Bilateral vestibulopathy (BVP) is a chronic condition in which patients have a reduction or absence of vestibular function in both ears. BVP is characterized by bilateral reduction of horizontal canal responses; however, there is increasing evidence that otolith function can also be affected. Cervical and ocular vestibular-evoked myogenic potentials (cVEMPs/oVEMPs) are relatively new tests of otolith function that can be used to test the saccule and utricle of both ears independently. Studies to date show that cVEMPs and oVEMPs are often small or absent in BVP but are in the normal range in a significant proportion of patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29703233/molecular-and-morphological-characterisation-of-pharyngostrongylus-kappa-mawson-1965-nematoda-strongylida-from-australian-macropodid-marsupials-with-the-description-of-a-new-species-p-patriciae-n-sp
#4
Tanapan Sukee, Ian Beveridge, Abdul Jabbar
BACKGROUND: Pharyngostrongylus kappa Mawson, 1965 is a nematode (Strongyloidea: Cloacininae), endemic to the sacculated forestomachs of Australian macropodid marsupials (kangaroos and wallaroos). A recent study revealed genetic variation within the internal transcribed spacer region of the nuclear ribosomal DNA among P. kappa specimens collected from Macropus giganteus Shaw and Osphranter robustus (Gould). This study aimed to characterise the genetic and morphological diversity within P...
April 27, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29698363/relationship-between-audio-vestibular-functional-tests-and-inner-ear-mri-in-meniere-s-disease
#5
Raphaële Quatre, Arnaud Attyé, Alexandre Karkas, Agnès Job, Georges Dumas, Sébastien Schmerber
OBJECTIVES: Meniere's disease is an inner ear disorder generally attributed to an endolymphatic hydrops. Different electrophysiological tests and imaging techniques have been developed to improve endolymphatic hydrops diagnosis. The goal of our study was to compare the sensitivity and the specificity of delayed inner ear magnetic resonance imaging (MRI) after intravenous injection of gadolinium with extratympanic clicks electrocochleography (EcochG), phase shift of distortion product otoacoustic emissions (shift-DPOAEs), and cervical vestibular-evoked myogenic potentials (cVEMP) for the diagnosis of Meniere's disease...
April 25, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29649050/temporal-bone-histopathology-in-cockayne-syndrome
#6
Ophir Handzel, Joseph B Nadol
: Cockayne syndrome (CS) is a rare autosomal recessive syndrome resulting in defective DNA repair. Its features include cachectic dwarfism, hearing loss, skin hypersensitivity to sunlight, premature aging, and dementia. Presented is a right temporal bone of a patient who died at the age of 29 years. The clinical course was compatible with type 1 CS, the classical form. Homozygous missense variant in the ERCC6 gene (Excision Repair Cross-Complementation group 6) was found, compatible with CS complementation group B...
April 11, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29624541/toward-optimizing-vemp-calculating-vemp-inhibition-depth-with-a-generic-template
#7
Kimberley S Noij, Mark J van Tilburg, Barbara S Herrmann, Piotr Marciniak, Steven D Rauch, John J Guinan
OBJECTIVES: Cervical vestibular evoked myogenic potentials (cVEMP) indirectly reveal the response of the saccule to acoustic stimuli through the inhibition of sternocleidomastoid muscle electromyographic response. VEMP inhibition depth (VEMPid) is a recently developed metric that estimates the percentage of saccular inhibition. VEMPid provides both normalization and better accuracy at low response levels than amplitude-normalized cVEMPs. Hopefully, VEMPid will aid in the clinical assessment of patients with vestibulopatholgy...
April 5, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29513752/anti-cancer-characteristics-and-ototoxicity-of-platinum-ii-amine-complexes-with-only-one-leaving-ligand
#8
Jerry D Monroe, Heidi L Hruska, Hannah K Ruggles, Kevin M Williams, Michael E Smith
Unlike cisplatin, which forms bifunctional DNA adducts, monofunctional platinum(II) complexes bind only one strand of DNA and might target cancer without causing auditory side-effects associated with cisplatin treatment. We synthesized the monofunctional triamine-ligated platinum(II) complexes, Pt(diethylenetriamine)Cl, [Pt(dien)Cl]+, and Pt(N,N-diethyldiethylenetriamine)Cl, [Pt(Et2dien)Cl]+, and the monofunctional heterocyclic-ligated platinum(II) complexes, pyriplatin and phenanthriplatin, and compared their 5'-GMP binding rates, cellular compartmental distribution and cellular viability effects...
2018: PloS One
https://www.readbyqxmd.com/read/29510119/domineering-non-autonomy-in-vangl1-vangl2-double-mutants-demonstrates-intercellular-pcp-signaling-in-the-vertebrate-inner-ear
#9
Michelle L Stoller, Orvelin Roman, Michael R Deans
The organization of polarized stereociliary bundles is critical for the function of the inner ear sensory receptor hair cells that detect sound and motion, and these cells present a striking example of Planar Cell Polarity (PCP); the coordinated orientation of polarized structures within the plane of an epithelium. PCP is best understood in Drosophila where the essential genes regulating PCP were first discovered, and functions for the core PCP proteins encoded by these genes have been deciphered through phenotypic analysis of core PCP gene mutants...
May 1, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29499975/the-double-dutch-technique-a-new-way-of-creating-an-ileocystoplasty-with-a-lengthy-catheterizable-ileal-tube
#10
P D Polm, S Beyerlein, A J Klijn, T P V M de Jong, P Dik
INTRODUCTION: A tubularized conduit from an open 2-cm vascularized ileal segment is a frequently used technique to create a continent catheterizable channel in cases of an inappropriate or absent appendix. In the long term, many patients experience catheterization problems with the classic ileal segment tube, and even more with spiral or double-segment tubes. OBJECTIVE: The objective of this paper was to introduce an ileocystoplasty modification combined with a long ileal segment tube that has better support by surrounding tissue than other lengthy ileal segment tubes...
February 7, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29459846/vestibular-dysfunctions-in-sudden-sensorineural-hearing-loss-a-systematic-review-and-meta-analysis
#11
Huiqian Yu, Huawei Li
Background: Sudden sensorineural hearing loss (SSHL) not only involves cochlear function but might also be accompanied by vestibular disturbances. The assessment of vestibular function could be of great relevance in SSHL. Objective: To investigate the prevalence of vestibulocochlear lesions in SSHL and the correlation of specific vestibular organs with hearing prognosis. Data sources: A complete literature search of eligible studies in the PubMed and EMBASE databases was performed...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29447806/pediatric-meniere-s-disease
#12
Chi Wang, Chien-Hao Wu, Po-Wen Cheng, Yi-Ho Young
OBJECTIVE: This study adopted an inner ear test battery comprising audiometry, and ocular vestibular evoked myogenic potential (oVEMP), cervical VEMP (cVEMP), and caloric tests to investigate the sequence of inner ear deficits in pediatric Meniere's disease (MD). METHODS: From 2005 to 2016, a total of 24 MD children aged <15 years old underwent otoscopy, CT scan, blood test, and an inner ear test battery. Nine subjects were males and 15 were females, with mean age of 12 years...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29393561/ultrasound-and-computed-tomography-of-sacculitis-and-appendicitis-in-a-rabbit
#13
Maurizio Longo, Florence Thierry, Kevin Eatwell, Tobias Schwarz, Jorge Del Pozo, Jenna Richardson
A 9-month-old neutered male rabbit was referred for lethargy, anorexia, and gastrointestinal stasis. Routine hematology, serum biochemistry, and diagnostic imaging were performed. Computed tomography revealed a wall thickening of the sacculus rotundus and appendix, which was further confirmed on abdominal ultrasound. Full thickness biopsies were collected with histopathology diagnosing a chronic multifocal heterophilic granulomatous sacculitis and appendicitis. The patient was treated medically and at 6 weeks follow-up, clinical signs and intestinal changes had completely regressed...
February 2, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29324449/toward-optimizing-vestibular-evoked-myogenic-potentials-normalization-reduces-the-need-for-strong-neck-muscle-contraction
#14
Kimberley S Noij, Barbara S Herrmann, Steven D Rauch, John J Guinan
BACKGROUND: The cervical vestibular evoked myogenic potential (cVEMP) represents an inhibitory reflex of the saccule measured in the ipsilateral sternocleidomastoid muscle (SCM) in response to acoustic or vibrational stimulation. Since the cVEMP is a modulation of SCM electromyographic (EMG) activity, cVEMP amplitude is proportional to muscle EMG amplitude. We sought to evaluate muscle contraction influences on cVEMP peak-to-peak amplitudes (VEMPpp), normalized cVEMP amplitudes (VEMPn), and inhibition depth (VEMPid)...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/29310507/inner-ear-test-battery-in-guinea-pig-models-a-review
#15
Yi-Ho Young
OBJECTIVE: This study reviewed the development of the inner ear test battery comprising auditory brainstem response (ABR), and caloric, ocular vestibular-evoked myogenic potential (oVEMP), and cervical vestibular-evoked myogenic potential (cVEMP) tests in guinea pig models at our laboratory over the last 20 years. Detailed description of the methodology for testing the small animals is also included. METHODS: Inner ear disorders, i.e. ototoxicity, noise exposure, or perilymph fistula were established in guinea pig models first...
January 8, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29288383/transcription-factors-regulating-embryonic-development-of-pulmonary-vasculature
#16
Craig Bolte, Jeffrey A Whitsett, Tanya V Kalin, Vladimir V Kalinichenko
Lung morphogenesis is a highly orchestrated process beginning with the appearance of lung buds on approximately embryonic day 9.5 in the mouse. Endodermally derived epithelial cells of the primitive lung buds undergo branching morphogenesis to generate the tree-like network of epithelial-lined tubules. The pulmonary vasculature develops in close proximity to epithelial progenitor cells in a process that is regulated by interactions between the developing epithelium and underlying mesenchyme. Studies in transgenic and knockout mouse models demonstrate that normal lung morphogenesis requires coordinated interactions between cells lining the tubules, which end in peripheral saccules, juxtaposed to an extensive network of capillaries...
2018: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/29283095/evaluation-of-cervical-vestibular-evoked-myogenic-potential-in-subjects-with-chronic-noise-exposure
#17
Nehal Mamdouh Abd El-Salam, Elshahat Ibrahem Ismail, Ayman El-Saeed El-Sharabasy
OBJECTIVE: Noise has been recognized as a major cause of cochlear damage resulting in both tinnitus and hearing loss. On the other hand, damage to the vestibular system, especially the saccule, can be considered as a potential problem. The cervical vestibular-evoked myogenic potentials (cVEMPs) have been established as a clinical test of measuring both sac-cular and inferior vestibular nerve function. Therefore, it is thought to be sensitive to the noise-induced damage to the vestibular system...
December 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29198950/comparison-among-ultrasonic-electrical-apparatus-and-toxic-chemicals-for-vestibular-lesion-in-mice
#18
Yusuke Yamaoka, Chikara Abe, Hironobu Morita
BACKGROUND: The vestibular lesion (VL) is required to examine the physiological function of the vestibular system in animals. Toxic chemicals or electrical apparatus have been used for the VL, however, they are not ideal as they have low specificity, and can result in unintended damage, and systemic toxic effect. NEW METHOD: Localized vibration-induced VL, using an ultrasonicator, is expected to overcome the problems associated with chemical and electrical lesions...
February 1, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29194625/laryngeal-chondronecrosis-after-radiation-therapy-in-a-dog
#19
J Bertran, M Martinez, M Breit, M A McLoughlin, K L Ham, E Warry, V Wavreille
A 5-year-old pug presented with a soft tissue swelling on the ventral neck and moderate stridor with associated respiratory effort. This patient received hypofractionated radiotherapy for metastatic upper lip mast cell tumour and to the submandibular lymph nodes 6 months before presentation. Oral examination showed moderate elongation of the soft palate, stage III laryngeal collapse with only the right laryngeal saccule mildly everted and exuberant pale epiglottal and left pharyngeal mucosa. Staphylectomy, resection of the epiglottal mucosa and left arytenoid lateralisation were performed...
November 30, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29117061/three-dimensional-analysis-of-the-fundus-of-the-human-internal-acoustic-canal
#20
Nadine Schart-Morén, Sune Larsson, Helge Rask-Andersen, Hao Li
OBJECTIVES: Documentation of the nerve components in the internal acoustic canal is essential before cochlea implantation surgery. Interpretations may be challenged by wide anatomical variations of the VIIIth nerve and their ramifications. Malformations may further defy proper nerve identification. DESIGN: Using microcomputed tomography, we analyzed the fundus bone channels in an archival collection of 113 macerated human temporal bones and 325 plastic inner molds...
November 7, 2017: Ear and Hearing
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