keyword
https://read.qxmd.com/read/38469594/acute-histological-reactions-in-the-otolith-organs-to-inner-ear-drug-delivery-through-a-cochlear-implant
#1
JOURNAL ARTICLE
Raquel Manrique-Huarte, Marta Álvarez de Linera-Alperi, Nicolás Pérez-Fernández, Manuel Manrique
INTRODUCTION: Cochlear implantation is currently regarded as a safe and minimally invasive procedure. However, cochlear implantation can have an impact on vestibular function, despite the lack of correlation between patient symptomatology and damage in vestibular tests. Thus, the present study aims to analyze the presence of hydrops and histological reactions at the level of the vestibule after cochlear implantation with dexamethasone pump delivery in Macaca fascicularis (Mf). MATERIALS AND METHODS: A detailed histological study was conducted on a total of 11 Mf...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38370888/investigation-of-aspergillosis-outbreak-in-young-ducklings-unraveling-the-role-of-hatcheries-in-aspergillus-fumigatus-transmission
#2
JOURNAL ARTICLE
Ahmed El-Shemy, Hoda Mekky, Mohamed Bosila, Khaled Elbayoumi, Mohamed Amer, Mohamed Elaish
OBJECTIVE: Aspergillosis is a disease that affects several species of birds and causes substantial losses in the poultry business. The purpose of the investigation was to identify the pathogen responsible for a respiratory outbreak among juvenile ducklings. MATERIALS AND METHODS: An epidemic of Aspergillosis infected a total of 800 Muscovy ducks that were being reared in El-Beheira Governorate. Tissue samples were obtained to isolate suspected fungi from diseased birds and the hatchery environment...
December 2023: Journal of Advanced Veterinary and Animal Research
https://read.qxmd.com/read/38363783/development-of-the-terminal-air-spaces-in-the-gray-short-tailed-opossum-monodelphis-domestica-3d-reconstruction-by-microcomputed-tomography
#3
JOURNAL ARTICLE
Kirsten Ferner
Marsupials are born with structurally immature lungs when compared to eutherian mammals. The gray short-tailed opossum (Monodelphis domestica) is born at the late canalicular stage of lung development. Despite the high degree of immaturity, the lung is functioning as respiratory organ, however supported by the skin for gas exchange during the first postnatal days. Consequently, the majority of lung development takes place in ventilated functioning state during the postnatal period. Microcomputed tomography (μCT) was used to three-dimensionally reconstruct the terminal air spaces in order to reveal the timeline of lung morphogenesis...
2024: PloS One
https://read.qxmd.com/read/38353199/pyolaryngocele-presenting-with-acute-onset-stridor
#4
JOURNAL ARTICLE
Shyam Sabat, Luis Gonzalez, Amit Agarwal
CASE PRESENTATION: This case describes the classic imaging findings of pyolaryngocele and highlights the importance of prompt imaging for diagnosis of clinically occult airway lesions. The case also highlights how pyolaryngoceles can become large and present with acute-onset clinical symptoms, including stridor and dyspnea. DISCUSSION: Pyolaryngoceles represent an uncommon but life-threatening complication of laryngoceles. Laryngoceles are frequently seen as an incidental, abnormal, air-filled dilation of the laryngeal saccule related to various local pathologies of the larynx...
November 2023: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38350105/uterine-sacculation-with-entrapped-placenta-after-delivery
#5
JOURNAL ARTICLE
Michael T Solotke, Glenn Boyles, Kara Rood, Emily Hinchcliff, Jeanne M Horowitz, Lynn M Yee
BACKGROUND: Uterine sacculation refers to a temporary pouch or sac within the uterus that may contain the placenta or fetal parts and that may be diagnosed antepartum or after delivery. There is very limited published information about this rare condition and its management. CASES: We report two cases of uterine sacculation with entrapped placenta diagnosed immediately postpartum, managed with two different approaches. In one case, the patient underwent immediate laparotomy and placental extraction...
February 13, 2024: Obstetrics and Gynecology
https://read.qxmd.com/read/38326635/morphological-chest-ct-changes-in-cystic-fibrosis-and-massive-hemoptysis
#6
JOURNAL ARTICLE
Martha Dohna, Hilmar Kühl, Sivagurunathan Sutharsan, Nora Bruns, Van Dai Vo Chieu, Susanne Hellms, Norman Kornemann, Michael J Montag
BACKGROUND: Massive hemoptysis (MH) is a rare but potentially life-threatening condition of patients with mainly advanced cystic fibrosis (CF). Morphological lung changes are aggravated with disease progression. The aim of this study was to determine whether morphological lung changes differ between patients with CF (pwCF) who have MH and pwCF without MH. METHODS: Chest computed tomography (CT) scans of pwCF and MH acquired at a maximum of 4 months prior to MH (1/2008 to 2/2015) were evaluated for morphological changes and bronchial artery (BA) diameters...
February 7, 2024: Radiologie (Heidelb)
https://read.qxmd.com/read/38326448/assessing-the-optimal-mri-descriptors-to-diagnose-m%C3%A3-ni%C3%A3-re-s-disease-and-the-added-value-of-analysing-the-vestibular-aqueduct
#7
JOURNAL ARTICLE
Steve Connor, Irumee Pai, Philip Touska, Sarah McElroy, Sebastien Ourselin, Joseph V Hajnal
OBJECTIVES: To evaluate the diagnostic performance and reliability of MRI descriptors used for the detection of Ménière's disease (MD) on delayed post-gadolinium MRI. To determine which combination of descriptors should be optimally applied and whether analysis of the vestibular aqueduct (VA) contributes to the diagnosis. MATERIALS AND METHODS: This retrospective single centre case-control study evaluated delayed post-gadolinium MRI of patients with Ménièriform symptoms examined consecutively between Dec 2017 and March 2023...
February 7, 2024: European Radiology
https://read.qxmd.com/read/38295585/nestin-expressing-cells-are-mitotically-active-in-the-mammalian-inner-ear
#8
JOURNAL ARTICLE
Olivia Kalmanson, Hiroki Takeda, Sean R Anderson, Anna Dondzillo, Samuel Gubbels
Nestin expression is associated with pluripotency. Growing evidence suggests nestin is involved in hair cell development. The objective of this study was to investigate the morphology and role of nestin-expressing cells residing in the early postnatal murine inner ear. A lineage-tracing nestin reporter mouse line was used to further characterize these cells. Their cochleae and vestibular organs were immunostained and whole-mounted for cell counting. We found Nestin-expressing cells present in low numbers throughout the inner ear...
January 23, 2024: Hearing Research
https://read.qxmd.com/read/38197496/surgical-considerations-in-inner-ear-gene-therapy-from-human-temporal-bone-anatomy
#9
JOURNAL ARTICLE
Alyssa Brown, MengYu Zhu, Alireza Rohani, Hanif Ladak, Sumit K Agrawal, Konstantina M Stankovic, D Bradley Welling
OBJECTIVE(S): Recently directed methods of inner ear drug delivery underscore the necessity for understanding critical anatomical dimensions. This study examines anatomical measurements of the human middle and inner ear relevant for inner ear drug delivery studied with three different imaging modalities. METHODS: Post-mortem human temporal bones were analyzed using human temporal bone histopathology (N = 24), micro computerized tomography (μCT; N = 4), and synchrotron radiation phase-contrast imaging (SR-PCI; N = 7)...
January 10, 2024: Laryngoscope
https://read.qxmd.com/read/38165436/the-importance-of-bone-density-and-anatomical-structure-in-superior-semicircular-canal-dehiscence
#10
JOURNAL ARTICLE
Güler Berkiten, Cem Çelik, Melis Koşar Tunç, Defne Gürbüz, Hasan Sami Bircan, Belgin Tutar, Ertan Berkiten, Yavuz Uyar
OBJECTIVE: This study investigates the importance of bone density, surface area, and diameter of anatomical structures of the superior semicircular canal (SSC), lateral semicircular canal (LSC), posterior semicircular canal (PSC), utricle, and saccule in patients diagnosed with superior semicircular canal dehiscence (SSCD). MATERIALS AND METHODS: The bone density, surface area, and diameter of SSC, LSC, PSC, utricle, and saccule were measured and compared between the SSCD group and control group...
January 2, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38148055/mitophagy-decreases-in-the-peripheral-vestibular-system-of-aged-c57bl-6j-mice
#11
JOURNAL ARTICLE
Sung Il Cho, Eu-Ri Jo, Suhyun Lee
BACKGROUND/AIM: Mitophagy is a cardinal process for maintaining healthy and functional mitochondria. A decline in mitophagy has been associated with age-related pathologies. We aimed to investigate mitophagy changes in age-related balance problems using an animal model. MATERIALS AND METHODS: C57BL/6J mice were divided into young (1 month old) and aged (12 months old) groups. Balance performance, mitochondrial DNA integrity, ATP content, mitophagic process, and mitophagy-related genes and proteins were investigated in both groups...
2024: In Vivo
https://read.qxmd.com/read/38130821/head-centric-computing-for-vestibular-stimulation-under-head-free-conditions
#12
JOURNAL ARTICLE
Barbara La Scaleia, Claudia Brunetti, Francesco Lacquaniti, Myrka Zago
Background: The vestibular end organs (semicircular canals, saccule and utricle) monitor head orientation and motion. Vestibular stimulation by means of controlled translations, rotations or tilts of the head represents a routine manoeuvre to test the vestibular apparatus in a laboratory or clinical setting. In diagnostics, it is used to assess oculomotor postural or perceptual responses, whose abnormalities can reveal subclinical vestibular dysfunctions due to pathology, aging or drugs. Objective: The assessment of the vestibular function requires the alignment of the motion stimuli as close as possible with reference axes of the head, for instance the cardinal axes naso-occipital, interaural, cranio-caudal...
2023: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38081224/masseter-vestibular-evoked-myogenic-potential-result-of-possible-meniere-s-patients
#13
JOURNAL ARTICLE
Meliha Basoz, Ozlem Konukseven, Aysegul Yabacı
BACKGROUND: The Masseter Vestibular-Evoked Myogenic Potential (mVEMP) test evaluates the vestibulo-masseteric reflex neural pathway between the sound-stimulated saccule hair cells and the motor neurons of the trigeminal nerve. PURPOSE: This study aims to investigate the contribution of mVEMP to the conclusive diagnosis of recurrent vestibulopathy patients that were diagnosed with Possible Ménière's disease. METHODS: The study includes 20 healthy individuals aged 18-40 years and 20 patients that were diagnosed with possible Ménière's disease according to the American Academy of Otorhinolaryngology and Head and Neck Surgery (AAO-HNS, 1995) Guidelines for the Definition of Ménière's Disease...
December 11, 2023: Journal of the American Academy of Audiology
https://read.qxmd.com/read/38051445/mdct-and-mri-in-bronchiectasis-in-older-children-and-young-adults%C3%A2-a-non-inferiority-trial
#14
JOURNAL ARTICLE
Lokesh, Manisha Jana, Priyanka Naranje, Ashu Seith Bhalla, Sushil K Kabra, Vijay Hadda, Arun Kumar Gupta
OBJECTIVES: To compare and evaluate the usefulness of magnetic resonance imaging (MRI) with computed tomography (CT) in bronchiectasis; to compare MRI and CT scores with pulmonary function tests (PFT) and to evaluate the role of Diffusion-weighted imaging (DWI) in bronchiectasis. METHODS: In this prospective study, 25 patients between 7-21 y of age with a clinical/radiological diagnosis of bronchiectasis underwent MDCT and MRI chest. MRI and CT scoring was performed using modified Bhalla-Helbich's score by two independent radiologists for all parameters...
December 5, 2023: Indian Journal of Pediatrics
https://read.qxmd.com/read/38010492/lung-patterning-is-a-distal-to-proximal-gradient-of-cell-allocation-and-fate-decision-a-general-paradigm-a-gradient-of-distal-to-proximal-distribution-and-differentiation-of-tip-progenitors-produces-distinct-compartments-in-the-lung
#15
JOURNAL ARTICLE
Kuan Zhang, Thin Aung, Erica Yao, Pao-Tien Chuang
Recent studies support a model in which the progeny of SOX9+ epithelial progenitors at the distal tip of lung branches undergo cell allocation and differentiation sequentially along the distal-to-proximal axis. Concomitant with the elongation and ramification of lung branches, the descendants of the distal SOX9+ progenitors are distributed proximally, express SOX2, and differentiate into cell types in the conducting airways. Amid subsequent sacculation, the distal SOX9+ progenitors generate alveolar epithelial cells to form alveoli...
November 27, 2023: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://read.qxmd.com/read/37955566/fish-hearing-revealed-do-we-understand-hearing-in-critical-fishes-and-marine-tetrapods
#16
JOURNAL ARTICLE
Bernd Fritzsch, Karen L Elliott
Hearing evolved in lampreys with a frequency range of 50-200 Hz. This hearing range is comparable to that of elasmobranchs, most non-teleosts, and lungfish. Elasmobranchs most likely use the saccule and the papilla neglecta (PN) for hearing. In non-teleosts and teleosts, lungfish, and certain tetrapods the saccule is the likely sensor for sound reception while the lagena and the PN are important for gravistatic sensing. Coelacanth and most tetrapods have a basilar papilla (BP) for hearing. In coelacanth and tetrapods, the hair cells of the BP are in contact with a basilar and a tectorial membrane...
November 1, 2023: Journal of the Acoustical Society of America
https://read.qxmd.com/read/37938046/comparison-of-the-saccules-and-lagenae-in-six-macrourid-fishes-from-different-deep-sea-habitatsa
#17
JOURNAL ARTICLE
Xiaohong Deng, Hans-Joachim Wagner, Arthur N Popper
There are substantial interspecific differences in the morphology of the ears of the more than 34 000 living fish species. However, almost nothing is known about the functional significance of these differences. One reason is that most comparative studies have been conducted on shallow-water species with far less focus on the numerous species that inhabit the depths of the oceans. Thus, to get a better sense of ear diversity in fishes and its potential role in hearing, this study focuses on the saccule and lagena, the primary auditory end organs, in six species of the family Macrouridae (rattails), a large group of fishes that typically inhabit depths from 1000 to 4000 m...
November 1, 2023: Journal of the Acoustical Society of America
https://read.qxmd.com/read/37903687/features-associated-with-high-risk-of-recurrence-in-saccular-laryngeal-cysts-a-systematic-review-and-qualitative-synthesis
#18
REVIEW
Cecilia Botti, Francesco Chiari, Arianna Burato, Giulia Molinari, Livio Presutti, Gabriele Molteni, Ignacio Javier Fernandez
INTRODUCTION: Saccular cysts are rare benign anomalies of the larynx (1.5% of laryngeal anomalies) determined by dilatation of the laryngeal saccule. They can be congenital or acquired. Clinical manifestation depends on the site of the cyst and the age of the patient. Children frequently have stridor and dyspnea, while adults usually complain of dysphonia.The therapeutic approach can be surgical or nonsurgical (needle aspiration or drainage).However, guidelines on the management of this disease are lacking in the literature...
October 28, 2023: Journal of Voice
https://read.qxmd.com/read/37767687/noise-induced-damage-in-the-zebrafish-inner-ear-endorgans-evidence-for-higher-acoustic-sensitivity-of-saccular-and-lagenar-hair-cells
#19
JOURNAL ARTICLE
Ieng Hou Lau, Raquel O Vasconcelos
The three otolithic endorgans of the inner ear are known to be involved in sound detection in different teleost fishes, yet their relative roles for auditory-vestibular functions within the same species remain unclear. In zebrafish (Danio rerio), saccule and utricle are thought to play key functions in encoding auditory and vestibular information, respectively, but the biological function of the lagena is not clear. We hypothesized that the zebrafish saccule serves as a primary auditory endorgan, making it more vulnerable to noise exposure, and that lagena might have an auditory function given its connectivity to the saccule and dominant vestibular function of the utricle...
September 28, 2023: Journal of Experimental Biology
https://read.qxmd.com/read/37734036/prenatal-fgfr2-signaling-via-pi3k-akt-specifies-the-pdgfra-myofibroblast
#20
JOURNAL ARTICLE
Matthew R Riccetti, Jenna Green, Thomas J Taylor, Anne-Karina T Perl
It is well known that Fibroblast Growth Factor Receptor 2 (FGFR2) signaling is critical for proper lung development. Recent studies demonstrate that epithelial FGFR2 signaling during the saccular phase of lung development (sacculation) regulates AT1 and AT2 cell differentiation. During sacculation, Platelet-Derived Growth Factor Receptor Alpha-positive (PDGFRA+ ) lung fibroblasts exist as three functional subtypes: contractile myofibroblasts, ECM-producing matrix fibroblasts, and lipofibroblasts. All three subtypes are required during alveolarization to establish a niche that supports alveolar type-2 epithelial (AT2) self-renewal and alveolar type-1 epithelial (AT1) differentiation...
September 21, 2023: American Journal of Respiratory Cell and Molecular Biology
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