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https://www.readbyqxmd.com/read/29750475/effects-of-losartan-and-allopurinol-on-cardiorespiratory-regulation-in-obstructive-sleep-apnoea
#1
Barbara J Morgan, Mihaela Teodorescu, David F Pegelow, Emily R Jackson, Devin L Schneider, David T Plante, James P Gapinski, Scott J Hetzel, John M Dopp
Chemoreflex sensitization produced by chronic intermittent hypoxia (CIH) in rats is attenuated by angiotensin II type 1 receptor (AT1 R) blockade. AT1 R blockade and xanthine oxidase inhibition both ameliorate CIH-induced endothelial dysfunction. We hypothesized treatment with losartan and allopurinol would reduce chemoreflex sensitivity and improve hypoxic vasodilation in patients with obstructive sleep apnoea (OSA). Eighty-six hypertensive patients with apnoea-hypopnoea index ≥25 events/hr and no other cardiovascular, pulmonary, renal, or metabolic disease were randomly assigned to receive allopurinol, losartan, or placebo for 6 weeks...
May 11, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29727888/-heart-failure-despite-low-bnp-level-paradoxon-or-pathfinder-a-case-of-pericarditis-constrictiva
#2
Henning Dopp, Petra Maagh, Axel Meissner
HISTORY AND CLINICIAL FINDINGS:  We elaborate a case of a 48-year old patient of indian descent who presented with shortness of breath, lower extremity edema and ascites in our emergency unit.One year beforehand tuberculous pleuritis was diagnosed and treated in accordance with guidelines. INVESTIGATIONS:  CT-Scan of the heart revealed a pericardial thickening with calcifications. Echocardiographic examination and invasive pressure measurement did not provide any clear evidence of pericarditis constrictiva...
May 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29619643/economic-impact-of-multisystemic-therapy-for-child-abuse-and-neglect
#3
Alex R Dopp, Cindy M Schaeffer, Cynthia Cupit Swenson, Jennifer S Powell
This study evaluated the economics of Multisystemic Therapy for Child Abuse and Neglect (MST-CAN) by applying the Washington State Institute for Public Policy (WSIPP) cost-benefit model to data from a randomized effectiveness trial with 86 families (Swenson et al. in JFP 24:497-507, 2010b). The net benefit of MST-CAN, versus enhanced outpatient treatment, was $26,655 per family at 16 months post-baseline. Stated differently, every dollar spent on MST-CAN recovered $3.31 in savings to participants, taxpayers, and society at large...
April 4, 2018: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/29561178/effect-of-chronic-intermittent-hypoxia-on-angiotensin-ii-receptors-in-the-central-nervous-system
#4
Barbara J Morgan, Nicole Schrimpf, Morgan Rothman, Ann Mitzey, Mark S Brownfield, Robert C Speth, John M Dopp
Chronic intermittent hypoxia (CIH) increases basal sympathetic nervous system activity, augments chemoreflex-induced sympathoexcitation, and raises blood pressure. All effects are attenuated by systemic or intracerebroventricular administration of angiotensin II type 1 receptor (AT1 R) antagonists. This study aimed to quantify the effects of CIH on AT1 R- and AT2 R-like immunoreactivity in the rostroventrolateral medulla (RVLM) and paraventricular nucleus of the hypothalamus (PVN), central regions that are important components of the extended chemoreflex pathway...
March 21, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29491486/low-nocturnal-diastolic-ocular-perfusion-pressure-as-a-risk-factor-for-ntg-progression-a-5-year-prospective-study
#5
Pushpa Raman, Nurull Bahya Suliman, Mimiwati Zahari, Michael Kook, Norlina Ramli
OBJECTIVE: To assess the relationship between baseline intraocular pressure (IOP), blood pressure (BP) and ocular perfusion pressure (OPP), and the 5-year visual field progression in normal-tension glaucoma (NTG) patients. DESIGN: Prospective, longitudinal study. METHODS: Sixty-five NTG patients who were followed up for 5 years are included in this study. All the enrolled patients underwent baseline 24-h IOP and BP monitoring via 2-hourly measurements in their habitual position and were followed up for over 5 years with reliable VF tests...
March 1, 2018: Eye
https://www.readbyqxmd.com/read/29356922/point-by-point-versus-multisite-electrode-mapping-in-vt-ablation-does-freedom-from-vt-recurrences-depend-on-mapping-catheter-an-observational-study
#6
Petra Maagh, Arnd Christoph, Markus Sebastian Müller, Henning Dopp, Gunnar Plehn, Axel Meissner
PURPOSE: This study was conducted with the purpose of determining whether or not the potential technical advantages of multi-electrode mapping catheters in catheter ablation (CA) of ventricular tachycardia (VT) result in any relevant clinical benefit for VT patients. METHODS: A single-center VT study, having taken place from 2012 to 2014 using a standard 3.5-mm catheter (Thermocool SF® group 1) and from 2014 to 2016 using a 1-mm multi-electrode-mapping catheter (PentaRay® group 2), was conducted...
March 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29317972/high-density-mapping-in-ventricular-tachycardia-ablation-a-pentaray-%C3%A2-study
#7
Petra Maagh, Arnd Christoph, Henning Dopp, Markus Sebastian Mueller, Gunnar Plehn, Axel Meissner
Background: High-density mapping of ventricular tachycardia (VT) with PentaRay® (Biosense-Webster) provides high resolution with discrimination of local abnormal electrograms and slow conducting channels. We evaluate the feasibility of PentaRay® to characterize the anatomical substrate and assume an influence of the outcome despite limitations. Methods: Over a 24-month period, 26 endocardial and four epicardial maps were obtained of 26 VT patients (18 ischemic cardiomyopathy (ICM, 69...
December 2017: Cardiology Research
https://www.readbyqxmd.com/read/29198387/international-differences-in-the-location-and-use-of-arteriovenous-accesses-created-for-hemodialysis-results-from-the-dialysis-outcomes-and-practice-patterns-study-dopps
#8
Ronald L Pisoni, Lindsay Zepel, Richard Fluck, Charmaine E Lok, Hideki Kawanishi, Gültekin Süleymanlar, Haimanot Wasse, Francesca Tentori, Jarcy Zee, Yun Li, Douglas Schaubel, Steven Burke, Bruce Robinson
BACKGROUND: Vascular access practice is strongly associated with clinical outcomes. There is substantial international variation in the use of arteriovenous fistulas (AVFs) and grafts (AVGs), as well as AVF maturation time and location. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: Hemodialysis patients participating in the prospective Dialysis Outcomes and Practice Patterns Study (DOPPS) from the United States, Japan, and Europe/ANZ (Belgium, France, Germany, Italy, Spain, Sweden, United Kingdom, Australia, and New Zealand), including 3,850 patients receiving 4,247 new AVFs and 842 patients receiving 1,129 new AVGs in 2009 to 2015...
November 29, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29122150/moving-towards-wellness-physical-activity-practices-perspectives-and-preferences-of-users-of-outpatient-mental-health-service
#9
Carol A Janney, Kathryn Fant Brzoznowski, Caroline R Richardson, Richard R Dopp, Michelle L Segar, Dara Ganoczy, Ann J Mooney, Lauren Emerson, Marcia Valenstein
OBJECTIVE: This study assessed the beliefs, barriers and preferences for physical activity (PA) among users of outpatient mental health (MH) services. Outpatient discussions with MH providers were also evaluated. METHOD: Between September-December 2014, patient advisors approached adult and family members in an academic MH clinic's waiting room on high volume patient visit days during peak clinic hours; 83% participated in the survey. Analyses were restricted to MH services users (n=295)...
November 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29121874/evaluating-the-effectiveness-of-iv-iron-dosing-for-anemia-management-in-common-clinical-practice-results-from-the-dialysis-outcomes-and-practice-patterns-study-dopps
#10
Bruce M Robinson, Maria Larkina, Brian Bieber, Werner Kleophas, Yun Li, Francesco Locatelli, Keith P McCullough, Jackie G Nolen, Friedrich K Port, Ronald L Pisoni
BACKGROUND: Anemia management protocols in hemodialysis (HD) units differ conspicuously regarding optimal intravenous (IV) iron dosing; consequently, patients receive markedly different cumulative exposures to IV iron and erythropoiesis-stimulating agents (ESAs). Complementary to IV iron safety studies, our goal was to gain insight into optimal IV iron dosing by estimating the effects of IV iron doses on Hgb, TSAT, ferritin, and ESA dose in common clinical practice. METHODS: 9,471 HD patients (11 countries, 2009-2011) in the DOPPS, a prospective cohort study, were analyzed...
November 9, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29040687/mortality-risk-in-patients-on-hemodiafiltration-versus-hemodialysis-a-real-world-comparison-from-the-dopps
#11
Francesco Locatelli, Angelo Karaboyas, Ronald L Pisoni, Bruce M Robinson, Joan Fort, Raymond Vanholder, Hugh C Rayner, Werner Kleophas, Stefan H Jacobson, Christian Combe, Friedrich K Port, Francesca Tentori
Background: With its convective component, hemodiafiltration (HDF) provides better middle molecule clearance compared with hemodialysis (HD) and is postulated to improve survival. A previous analysis of Dialysis Outcomes and Practice Patterns Study (DOPPS) data in 1998-2001 found lower mortality rates for high replacement fluid volume HDF versus HD. Randomized controlled trials have not shown uniform survival advantage for HDF; in secondary (non-randomized) analyses, better outcomes were observed in patients receiving the highest convection volumes...
October 11, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28941772/influence-of-the-copper-induced-viable-but-non-culturable-state-on-the-toxicity-of-pseudomonas-aeruginosa-towards-human-bronchial-epithelial-cells-in-vitro
#12
Elke Dopp, Jessica Richard, Zenyta Dwidjosiswojo, Anne Simon, Jost Wingender
The viable but non-culturable (VBNC) state of the opportunistic bacterium Pseudomonas aeruginosa was previously shown to be induced by copper ions in concentrations relevant to those in drinking water plumbing systems. This decrease of bacterial culturability without loss of viability might have an influence on human health due to an underestimation of the actual contamination in drinking water systems. The aim of this study was to investigate the influence of culturable P. aeruginosa, viable but not culturable as well as culturable again after resuscitation from the VBNC state on human bronchial epithelial cells (BEAS-2B) in vitro...
November 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28880814/investigation-of-full-scale-ozonation-at-a-municipal-wastewater-treatment-plant-using-a-toxicity-based-evaluation-concept
#13
Fabian Itzel, Linda Gehrmann, Helena Bielak, Paul Ebersbach, Andrea Boergers, Heinrich Herbst, Christian Maus, Anne Simon, Elke Dopp, Monika Hammers-Wirtz, Torsten C Schmidt, Jochen Tuerk
Effluents from municipal wastewater treatment plants (WWTPs) are known to be point sources of micropollutants for surface waters. The aim of this study was to examine a reconstructed full-scale ozonation equipped with a pump-injector system for ozone (O3 ) dosage and a fluidized moving-bed reactor as biological posttreatment at a municipal WWTP utilizing an effect-directed approach. This approach consists of chemical analysis in combination with toxicological tests for the assessment of treatment efficiency of the plant...
2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28877202/shorter-dialysis-session-length-was-not-associated-with-lower-mental-health-and-physical-functioning-in-elderly-hemodialysis-patients-results-from-the-japan-dialysis-outcome-and-practice-patterns-study-j-dopps
#14
Masashi Kitagawa, Ken-Ei Sada, Norikazu Hinamoto, Miho Kimachi, Yosuke Yamamoto, Yoshihiro Onishi, Shunichi Fukuhara
BACKGROUND: Health-related quality of life (HRQOL) is often prioritized over long-term survival in elderly patients. Although a longer dialysis session length (DSL) has been shown to reduce mortality, its effects on improving the HRQOL are unknown. METHODS: Using data from the Japan Dialysis Outcomes and Practice Patterns Study (J-DOPPS), patients aged ≥ 65 years on maintenance hemodialysis were enrolled. DSL was categorized as short (<210 minutes), medium (210-240 minutes), or long (>240 minutes)...
2017: PloS One
https://www.readbyqxmd.com/read/28834360/ras-inhibitor-is-not-associated-with-cardiovascular-benefits-in-patients-undergoing-hemodialysis-in-japan
#15
Masahide Mizobuchi, Hiroaki Ogata, Yoshihiro Onishi, Shingo Fukuma, Tadao Akizawa, Shunichi Fukuhara
Definitive evidence of whether renin angiotensin system (RAS) inhibition is beneficial on cardiovascular events (CVE) among patients undergoing hemodialysis (HD) is lacking. The objective of this study was to investigate the association of RAS inhibitor usage with CVEs in patients enrolled in the Dialysis Outcomes Practice Pattern Study in Japan (J-DOPPS). Association of RAS inhibitor prescription with outcomes including all-cause death, death caused by CVE, and hospitalization due to cardiac failure was investigated by using a multivariable Cox proportional hazards model...
August 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28771674/a-c-index-for-recurrent-event-data-application-to-hospitalizations-among-dialysis-patients
#16
Sehee Kim, Douglas E Schaubel, Keith P McCullough
We propose a C-index (index of concordance) applicable to recurrent event data. The present work addresses the dearth of measures for quantifying a regression model's ability to discriminate with respect to recurrent event risk. The data which motivated the methods arise from the Dialysis Outcomes and Practice Patterns Study (DOPPS), a long-running prospective international study of end-stage renal disease patients on hemodialysis. We derive the theoretical properties of the measure under the proportional rates model (Lin et al...
August 3, 2017: Biometrics
https://www.readbyqxmd.com/read/28742807/association-of-coping-strategies-with-mortality-and-health-related-quality-of-life-in-hemodialysis-patients-the-japan-dialysis-outcomes-and-practice-patterns-study
#17
Kakuya Niihata, Shingo Fukuma, Tadao Akizawa, Shunichi Fukuhara
BACKGROUND: Hemodialysis patients are exposed to disease- and treatment-related stresses, and use various coping strategies to deal with these stresses. Although some studies have reported the association of coping strategies with mortality or health-related quality of life (QOL) in some populations, the effect of coping strategies on clinical outcomes in hemodialysis patients remains unclear. We investigated the association in a longitudinal design among Japanese hemodialysis patients...
2017: PloS One
https://www.readbyqxmd.com/read/28724618/initiation-of-sevelamer-and-mortality-among-hemodialysis-patients-treated-with-calcium-based-phosphate-binders
#18
MULTICENTER STUDY
Hirotaka Komaba, Mia Wang, Masatomo Taniguchi, Suguru Yamamoto, Takanobu Nomura, Douglas E Schaubel, Abigail R Smith, Jarcy Zee, Angelo Karaboyas, Brian Bieber, Masafumi Fukagawa, Francesca Tentori
BACKGROUND AND OBJECTIVES: Prior studies have shown that sevelamer attenuates progression of arterial calcification and may reduce the risk of death compared with calcium-based phosphate binders. In clinical practice, however, sevelamer is used not only as an alternative but also as an add-on therapy in patients already being treated with calcium-based phosphate binders. We analyzed the Dialysis Outcomes and Practice Patterns Study (DOPPS) data to test the hypothesis that the initiation of sevelamer is associated with improved survival in patients on hemodialysis treated with calcium-based phosphate binders...
September 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28617161/insomnia-and-relationship-with-immunosuppressant-therapy-after-lung-transplantation
#19
Kalynn A Rohde, Zachary W Schlei, Krista M Katers, Ashley K Weber, Marissa M Brokhof, Donald S Hawes, Kelly L Radford, Mary L Francois, Nathan J Menninga, Richard Cornwell, Ruth Benca, Mary S Hayney, John M Dopp
BACKGROUND: Lung transplant recipients are at high risk of developing sleep disorders such as insomnia, but the prevalence and features are currently poorly characterized within this population. Since these disorders are associated with increased morbidity and mortality, it is important to identify them to optimize the care of lung transplant recipients. We sought to evaluate the prevalence of insomnia within our university-based lung transplant clinic and determine whether a relationship exists between insomnia and exposure to immunosuppressant medications following transplantation...
June 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/28333535/family-based-treatments-for-serious-juvenile-offenders-a-multilevel-meta-analysis
#20
Alex R Dopp, Charles M Borduin, Mark H White, Sofie Kuppens
OBJECTIVE: Researchers have identified several family-based treatments that hold considerable promise in reducing serious juvenile offending; however, these treatments remain underutilized by youth service systems. In the present study, we used meta-analysis to summarize the findings of research on family-based treatments for serious juvenile offenders. METHOD: We conducted a multilevel meta-analysis that modeled dependencies between multiple effect sizes from the same study...
April 2017: Journal of Consulting and Clinical Psychology
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