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Diabetes prevention

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https://www.readbyqxmd.com/read/29452335/change-in-cardiometabolic-risk-among-blacks-whites-and-hispanics-findings-from-the-health-and-retirement-study
#1
Uchechi A Mitchell, Jennifer A Ailshire, Eileen M Crimmins
Background: Blacks experience greater multi-system physiological dysregulation, or cumulative biological risk, which is associated with poor cardiometabolic health and mortality. In this study, we assess race differences in change in risk over four years among older whites, blacks and Hispanics. Method: We examined race differences in 4-year change in individual biomarkers and a cumulative measure of risk-cardiometabolic risk (CMR)-using data for each respondent from two waves of the Health and Retirement Study's biomarker assessment (n=5,512)...
February 14, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29451860/a-hierarchical-bayesian-tri-variate-analysis-on-factors-associated-with-anthropometric-measures-in-a-large-sample-of-children-and-adolescents-the-caspian-iv-study
#2
Roya Kelishadi, Zahra Heidari, Iraj Kazemi, Tohid Jafari-Koshki, Marjan Mansourian, Mohammad-Esmaeil Motlagh, Ramin Heshmat
BACKGROUND: This study aimed to assess determinants of anthropometric measures in a nationally representative sample of Iranian children and adolescents. METHODS: This nationwide study was conducted among 13,280 students, aged 6-18 years, who were randomly selected from 30 provinces in Iran. Anthropometric measures were determined by calibrated instruments. Demographic and socio-economic (SES) variables, lifestyle behaviors, family history of chronic disease and prenatal factors were studied, as well...
February 16, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29450884/is-sonographically-measured-cervical-length-at-37-weeks-gestation-associated-with-intrapartum-cesarean-section-a-prospective-cohort-study
#3
Bradley de Vries, Rajit Narayan, Kevin McGeechan, Stanley Santiagu, Ramesh Vairavan, Minke Burke, Hala Phipps, Jon Hyett
Cesarean section rates continue to increase globally. Prediction of intrapartum cesarean section could lead to preventative measures. Our aim was to assess the association between sonographically measured cervical length at 37 weeks' gestation and cesarean section among women planning a vaginal birth. The population was women with a low risk pregnancy or with gestational diabetes MATERIAL AND METHODS: This was a prospective cohort study conducted in a tertiary referral hospital in Sydney, Australia. 212 women with a low risk pregnancy or with gestational diabetes were recruited including 158 nulliparous and 54 parous women...
February 16, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29450481/messengers-of-truth-and-health-young-artists-of-color-raise-their-voices-to-prevent-diabetes
#4
Dean Schillinger, Natasha Huey
No abstract text is available yet for this article.
February 14, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29450408/effect-of-arginase-1-inhibition-on-the-incidence-of-autoimmune-diabetes-in-nod-mice
#5
Luis F Hernandez, Peter Buchwald, Midhat H Abdulreda
Metabolism of the amino acid L-arginine is implicated in many physiological and pathophysiological processes including autoimmune conditions such as type 1 diabetes (T1D). Alternate arginine metabolism through the citrulline-nitric oxide (NO) or the ornithine pathways can lead to proinflammatory or immune regulatory effects, respectively. In this report, we blocked the arginine-ornithine metabolic pathway by inhibiting the enzyme arginase-1 with Nω-hydroxy-nor-arginine (nor-NOHA) to make arginine more available to the alternate citrulline pathway for augmented NO production and increased incidence of autoimmune T1D in female non-obese diabetic (NOD) mice...
January 2018: Current Research in Diabetes & Obesity Journal
https://www.readbyqxmd.com/read/29449960/physician-initiated-clinical-study-of-limb-ulcers-treated-with-a-functional-peptide-sr-0379-from-discovery-to-a-randomized-double-blind-placebo-controlled-trial
#6
Hironori Nakagami, Ken Sugimoto, Takahiro Ishikawa, Taku Fujimoto, Toshifumi Yamaoka, Misa Hayashi, Eiji Kiyohara, Hiroshi Ando, Yuta Terabe, Yoichi Takami, Koichi Yamamoto, Yasushi Takeya, Minoru Takemoto, Masaya Koshizaka, Tamotsu Ebihara, Ayumi Nakamura, Mitsunori Nishikawa, Xiang Jing Yao, Hideki Hanaoka, Ichiro Katayama, Koutaro Yokote, Hiromi Rakugi
SR-0379 is a functional peptide that has wound healing effect with anti-microbial action, making it an ideal drug to prevent infection. To evaluate the safety, efficacy, and pharmacokinetics of SR-0379 for the treatment of leg ulcers, a physician-initiated, phase I/IIa, first-in-patient clinical study was designed. A multi-center, double-blind, randomized clinical study was conducted from October 2015 to September 2016. The inclusion criteria for leg ulcers were (1) diabetes or critical limb ischemia and (2) wound size <6 cm in diameter...
2018: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/29449958/a-mobile-phone-based-program-to-promote-healthy-behaviors-among-adults-with-prediabetes-study-protocol-for-a-pilot-randomized-controlled-trial
#7
Dina H Griauzde, Jeffrey T Kullgren, Brad Liestenfeltz, Caroline Richardson, Michele Heisler
Background: Rates of participation in Diabetes Prevention Programs (DPPs) are low. This may be due, in part, to low levels of autonomous motivation (i.e., motivation that arises from internal sources and sustains healthy behaviors over time) to prevent type 2 diabetes (T2DM) among many individuals with prediabetes. Mobile health (mHealth) technologies that incorporate principles from the Self-Determination Theory offer an effective and scalable approach to increase autonomous motivation levels...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29449952/variations-of-dietary-intake-by-glycemic-status-and-hispanic-latino-heritage-in-the-hispanic-community-health-study-study-of-latinos-hchs-sol
#8
Sarah S Casagrande, Daniela Sotres-Alvarez, Larissa Avilés-Santa, Matthew J O'Brien, Cristina Palacios, Cynthia M Pérez, Samantha A Reina, Xueyin Wang, Qibin Qi, Aida L Giachello, Rebeca A Espinoza Giacinto, Catherine C Cowie
Objective: A healthy diet is important for diabetes prevention and control; however, few studies have assessed dietary intake among US Hispanics/Latinos, a diverse population with a significant burden of diabetes. To address this gap in the literature, we determined intake of energy, macro/micronutrients, and vitamin supplements among Hispanics/Latinos by glycemic status and heritage. Research design and methods: Cross-sectional study of adults aged 18-74 years from the Hispanic Community Health Study/Study of Latinos (2008-2011) with complete baseline data on glycemic status and two 24-hour dietary recalls (n=13 089)...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29449950/impact-of-malnutrition-on-survival-and-healthcare-utilization-in-medicare-beneficiaries-with-diabetes-a-retrospective-cohort-analysis
#9
Naseer Ahmed, Yong Choe, Vikkie A Mustad, Sumita Chakraborty, Scott Goates, Menghua Luo, Jeffrey I Mechanick
Objective: The aim of this study was to examine the impact of pre-existing malnutrition on survival and economic implications in elderly patients with diabetes. Research design and methods: A retrospective observational study was conducted to examine the impact of malnutrition with or without other significant health conditions on survival time and healthcare costs using the Centers for Medicare and Medicaid Services (CMS) data from 1999 to 2014 for beneficiaries with a confirmed first date of initial diagnosis of diabetes (n=15 121 131)...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29449811/hdac6-inhibition-promotes-transcription-factor-eb-activation-and-is-protective-in-experimental-kidney-disease
#10
Angela S Brijmohan, Sri N Batchu, Syamantak Majumder, Tamadher A Alghamdi, Karina Thieme, Sarah McGaugh, Youan Liu, Suzanne L Advani, Bridgit B Bowskill, M Golam Kabir, Laurette Geldenhuys, Ferhan S Siddiqi, Andrew Advani
To contend with the deleterious effects of accumulating misfolded protein aggregates or damaged organelles cells rely on a system of quality control processes, among them the autophagy-lysosome pathway. This pathway is itself controlled by a master regulator transcription factor termed transcription factor EB (TFEB). When TFEB localizes to the cell nucleus it promotes the expression of a number of genes involved in protein clearance. Here, we set out to determine (1) whether TFEB expression is altered in chronic kidney disease (CKD); (2) whether inhibition of the cytosolic deacetylase histone deacetylase 6 (HDAC6) affects TFEB acetylation and nuclear localization; and (3) whether HDAC6 inhibition, in turn, alters the natural history of experimental CKD...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29449364/diabetic-cardiomyopathy-an-update-of-mechanisms-contributing-to-this-clinical-entity
#11
REVIEW
Guanghong Jia, Michael A Hill, James R Sowers
Heart failure and related morbidity and mortality are increasing at an alarming rate, in large part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes associated with heart failure are considerably worse for patients with diabetes mellitus than for those without diabetes mellitus. In people with diabetes mellitus, the presence of myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia, has led to the descriptive terminology, diabetic cardiomyopathy...
February 16, 2018: Circulation Research
https://www.readbyqxmd.com/read/29449147/relation-between-hba-1c-and-incident-cardiovascular-disease-over-a-period-of-6-years-in-the-hong-kong-population
#12
E Y F Wan, E Y T Yu, C S C Fung, W Y Chin, D Y T Fong, A K C Chan, C L K Lam
AIM: The current trend on diabetes management advocates replacing the paradigm from a uniform to an individualized patient-centered haemoglobin A 1c (HbA 1c ) target, but there is no consensus on the optimal HbA 1c level. The study aimed at examining the association between HbA 1c and the risk of cardiovascular diseases (CVD) for diabetic patients with different characteristics, in order to identify patient-centered treatment targets. METHODS: A retrospective cohort study was conducted on 115,782 Chinese adult primary care patients with type 2 diabetes mellitus (DM) but no known CVD history, who were prescribed antidiabetic medications in 2010-2011...
February 3, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29449096/evaluating-the-impact-of-diabetes-self-management-education-methods-on-knowledge-attitudes-and-behaviours-of-adult-patients-with-type-2-diabetes-mellitus
#13
Laura Adam, Colleen O'Connor, Alicia C Garcia
OBJECTIVES: Diabetes self-management refers to all activities patients undertake to care for their illness, promote health and prevent the long- and short-term effects of diabetes. This study compared the effectiveness of 2 diabetes self-management education methods by examining changes in glycated hemoglobin (A1C) levels and knowledge, attitudes and behaviours (KABs) after traditional group education (TE) or with diabetes conversation maps (CMs). The CMs group was postulated to show greater decrease in A1C levels and improved KABs scores compared to the TE group...
November 23, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29448969/prevalence-of-erectile-dysfunction-and-associated-factors-among-diabetic-men-attending-the-diabetic-clinic-at-felege-hiwot-referral-hospital-bahir-dar-north-west-ethiopia-2016
#14
Bizuayehu Walle, Kidist Reba Lebeta, Yamrot Debela Fita, Hordofa Gutema Abdissa
OBJECTIVE: Even though several scholars have conducted study in different part of the world on erectile dysfunction in patients diagnosed with diabetes mellitus, it's magnitude vary among their finding with the range between 20 and 90%. This study aimed at assessing the prevalence of erectile dysfunction and associated factors among diabetic clients. RESULTS: A cross sectional study was conducted from January 2016 to March, 2016. Systematic random sampling technique was used...
February 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29448285/-risk-factors-and-therapeutic-goals-for-primary-and-secondary-cardiovascular-prevention-significance-for-the-glaucoma-patient
#15
Claudia Hacke, Carl Erb, Burkhard Weisser
Hypertension, diabetes mellitus and dyslipidaemia are among the most important cardiovascular risk factors. In addition, there is an association with the development and progression of glaucoma. During the last years, there has been an intense discussion concerning optimal treatment goals for these risk factors. Recently, the American Heart Association has defined a blood pressure greater than 130/80 mmHg as hypertension and the European guidelines will follow this definition. These lower blood pressure limits increase the risk for a too strict blood pressure treatment with night values, which might be too low for glaucoma patients...
February 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29448118/calcium-channel-blockers-as-drug-repurposing-candidates-for-gestational-diabetes-mining-large-scale-genomic-and-electronic-health-records-data-to-repurpose-medications
#16
Jeffery A Goldstein, Lisa A Bastarache, Joshua C Denny, Dan M Roden, Jill M Pulley, David M Aronoff
New therapeutic approaches are needed for gestational diabetes mellitus (GDM), but must show safety and efficacy in a historically understudied population. We studied associations between electronic medical record (EMR) phenotypes and genetic variants to uncover drugs currently considered safe in pregnancy that could treat or prevent GDM. We identified 129 systemically active drugs considered safe in pregnancy targeting the proteins produced from 196 genes. We tested for associations between GDM and/or type 2 diabetes (DM2) and 306 SNPs in 130 genes represented on the Illumina Infinium Human Exome Bead Chip (DM2 was included due to shared pathophysiological features with GDM)...
February 12, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29448006/plasma-triglycerides-as-a-risk-factor-for-chronic-kidney-disease-in-type-2-diabetes-mellitus-evidence-from-the-northeastern-of-thailand
#17
Sojib Bin Zaman, Mohd Anisul Karim, Naznin Hossain, Gulam Muhammed Al Kibria, Sheikh Mohammed Shariful Islam
AIMS: To investigate the observational association between plasma triglyceride and CKD in patients with T2DM. METHODS: A hospital-based retrospective registry was used to obtain data of 3748 T2DM patients from May 2016 to October 2016. Anthropometric measurements and biochemical reports of T2DM patients with CKD were obtained by data extraction of medical records. CKD was defined according to the estimated glomerular filtration rate (eGFR <60mL/min/1.73 m 2 )...
February 12, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29447962/low-molecular-weight-fucoidan-attenuates-liver-injury-via-sirt1-ampk-pgc1%C3%AE-axis-in-db-db-mice
#18
Yuanyuan Zheng, Tiantian Liu, Zhiqiang Wang, Yang Xu, Quanbin Zhang, Dali Luo
Non-alcoholic fatty-liver disease (NAFLD), caused by elevated hepatic lipids, inflammation and oxidative stress, is the most common liver disease globally. Low molecular weight fucoidan (LMWF), a sulfated polysaccharide extracted from brown seaweeds, has shown strong anti-inflammatory and antioxidant activities, which has not been explored in diabetes-induced NAFLD. Therefore, the present study sought to determine whether LMWF protects obese diabetic db/db mice against NAFLD. Results showed LMWF administration decreased plasma level of alanine aminotransferase, aspartate aminotransferase, total cholesterol, and triglyceride, as well as alleviated hepatic accumulation of triglyceride and total cholesterol in db/db mice...
February 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29447854/risk-factors-associated-complications-for-postoperative-urinary-retention-after-lumbar-surgery-for-lumbar-spinal-stenosis
#19
Joshua L Golubovsky, Haariss Ilyas, Jinxiao Chen, Joseph E Tanenbaum, Thomas E Mroz, Michael P Steinmetz
BACKGROUND CONTEXT: Postoperative Urinary Retention (POUR) is a very common post-operative complication of all surgeries (5 - 70%) that may lead to complications such as urinary tract infection (UTI), bladder over-distention, autonomic dysregulation, and increased postoperative length of stay (LOS). Within the field of spine surgery, the reported incidence of POUR is highly variable (5.6 - 38%). Lack of clear stratification of surgical level, spinal pathology, and inadequate sample size is a major limitation of available studies concerning POUR following spine surgery that may lead to inconsistency in the incidence of POUR and the ability to model its occurrence and consequences...
February 12, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29447397/barriers-and-facilitators-of-diabetes-services-in-nepal-a-qualitative-evaluation
#20
Nicole Ide, James P LoGerfo, Biraj Karmacharya
For the past three decades, the burden of diabetes in Nepal has been steadily increasing, with an estimated 3% annual increase since the year 2000. Although the burden is increasing, the methods of addressing the challenge have remained largely unchanged. This study sought to assess the current state of diabetes services provided by health facilities and to identify the major barriers that people with diabetes commonly face in Nepal. For this qualitative study, we selected five health facilities of varying levels and locations...
February 13, 2018: Health Policy and Planning
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