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Skin and soft tissue infections

Gabriela Ensinck, Adriana Ernst, Gustavo Lazarte, Antonela Romagnoli, Yanina Sguassero, Nanci Míguez, Santiago López Papucci, Alicia Aletti, Ana Chiossone, Fernanda Pigozzi, Matías Pinotti, Ana Cantador
INTRODUCTION: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are a common reason for consultation in pediatrics. Most of them present as skin and soft tissue infections; however, invasive infections have increased during the last decade. OBJECTIVES: The main objective was to describe the clinical-epidemiological characteristics of CA-MRSA infections. The secondary objective was to compare prevalence, clinical presentation and antibiotic susceptibility with a pre-study period (1/2004-12/2007)...
April 1, 2018: Archivos Argentinos de Pediatría
Elizabeth Ann Misch, Christopher Saddler, James Muse Davis
PURPOSE OF REVIEW: This review describes recent trends in the epidemiology of nontuberculous mycobacteria (NTM), emerging pathogens, new insights into NTM pathogenesis, and advances in diagnosis and treatment. RECENT FINDINGS: Emerging pathogens include Mycobacterium chimaera and drug-resistant subspecies of Mycobacterium abscessus. Important virulence mechanisms of pathogenic NTM include the ability to alter the macrophage's permissiveness to intracellular bacterial growth...
March 19, 2018: Current Infectious Disease Reports
Jonathan D Scrafford, Buvana Reddy, Colleen Rivard, Rachel Isaksson Vogel
PURPOSE: To compare the rates of wound-related complications among women undergoing a cesarean section when the surgical team used intra-operative glove changing versus usual care. METHODS: All women undergoing a cesarean section at a single, county hospital were randomized to usual care or intra-operative glove changing prior to abdominal closure. Participants were randomized at the time of decision for cesarean section; surgeons were not blinded to the randomization arm...
March 19, 2018: Archives of Gynecology and Obstetrics
Marco Ellis, Lisa Hwang, Ni-Ka Ford, Konstantin Slavin
BACKGROUND: Full-thickness scalp defects pose a reconstructive problem, especially in the setting of infection, chemotherapy/radiation, and underlying cranial defects. Current options include dermal matrices, skin grafts, and local flaps. Local flaps often fail, requiring subsequent microvascular free flap reconstruction. OBJECTIVE: To describe the visor flap, a novel bipedicled advancement flap design, and its role in reconstruction of scalp defects. METHODS: A retrospective review of 21 adult patients who developed scalp defects reconstructed using the visor flap from 2013 to 2017...
March 14, 2018: Operative Neurosurgery (Hagerstown, Md.)
C Correa-Martinez, A Brentrup, K Hess, K Becker, A H Groll, F Schaumburg
Coprinopsis cinerea is an environmental fungus which can cause disseminated infections in immunocompromised patients, often leading to death. Here we report the case of a paediatric patient with an invasive wound infection due to C. cinerea, which was successfully treated with surgical debridement and oral posaconazole.
January 2018: New Microbes and New Infections
Adam J Pelzek, Bo Shopsin, Emily E Radke, Kayan Tam, Beatrix M Ueberheide, David Fenyö, Stuart M Brown, Qianhao Li, Ada Rubin, Yi Fulmer, William K Chiang, David N Hernandez, Hanane El Bannoudi, William E Sause, Alexis Sommerfield, Isaac P Thomsen, Andy O Miller, Victor J Torres, Gregg J Silverman
Staphylococcus aureus is a Gram-positive opportunistic pathogen that causes superficial and invasive infections in the hospital and community. High mortality from infection emphasizes the need for improved methods for prevention and treatment. Although S. aureus possesses an arsenal of virulence factors that contribute to evasion of host defenses, few studies have examined long-term humoral and B-cell responses. Adults with acute-phase skin and soft tissue infections were recruited; blood samples were obtained; and S...
March 13, 2018: MBio
Christy P Su, Levita Hidayat, Shafiqur Rahman, Veena Venugopalan
BACKGROUND: Medication reconciliation is a major patient safety concern, and the impact of a structured process to evaluate anti-infective agents at hospital discharge warrants further review. OBJECTIVE: The aim of this study was to (1) describe a structured, multidisciplinary approach to review anti-infectives at discharge and (2) measure the impact of a stewardship-initiated antimicrobial review process in identifying and preventing anti-infective-related medication errors (MEs) at discharge...
January 1, 2018: Journal of Pharmacy Practice
Hiroshige Mikamo, Yoshio Takesue, Yuji Iwamoto, Takahiko Tanigawa, Masaharu Kato, Yoko Tanimura, Shigeru Kohno
The objective of this open-label, randomised (i.e. 2:1 ratio), Phase 3 study was to compare the efficacy and safety of tedizolid phosphate 200 mg, once-daily treatment with that of linezolid 600 mg, twice-daily treatment for 7-14 days in Japanese adult patients (N = 125) with skin and soft tissue infections (SSTIs) and/or for 7-21 days for those with SSTI-related bacteraemia, caused by confirmed or highly suspected methicillin-resistant Staphylococcus aureus (MRSA). Primary outcome was clinical cure rate at test-of-cure (TOC, in SSTI: 7-14 days, in bacteraemia: 4-6 weeks after end-of-therapy [EOT]) time point in the microbiologically evaluable MRSA (ME-MRSA) population (N = 39)...
March 9, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
A Guiroy, A Sícoli, N Gonzalez Masanés, A Morales Ciancio, M Gagliardi, A Falavigna
Background: The paraspinal, posterolateral, or Wiltse approach is an old technique that observes the principles of an MIS procedure. The aim of this study was to provide a step-by-step description from the literature of the Wiltse paraspinal approach and analyze its main advantages and limitations. Methods: Here, we provide a step-by-step description of the Wiltse approach. Utilizing PubMed and Lilacs and the Mesh terms "Wiltse approach," "paraspinal approach," "muscle sparing approach," and "lumbar spine," we identified 10 papers...
2018: Surgical Neurology International
Silvano Esposito, Silvana Noviello, Francesco De Caro, Giovanni Boccia
Skin and soft tissue infections (SSTIs) involve a heterogeneous group of entities with different clinical presentations classified according to several specific criteria. Because of their great variability, their incidence and prevalence is difficult to accurately determine. Yet it is generally thought that the rate of SSTIs is globally increasing due to an aging population, strictly associated with the increase in the number of critical and immunocompromised patients. The aetiology of SSTIs is also extremely variable, reflecting the noteworthy heterogeneity of their clinical presentations and their epidemiology...
March 1, 2018: Le Infezioni in Medicina
Nicole M Acquisto, Ryan P Bodkin, Jack E Brown, Paul S Graman, Courtney Marie Cora Jones, Timmy Li, Dwight J Hardy, Elizabeth Dodds Ashley
OBJECTIVES: Skin and soft tissue infections (SSTI) caused by methicillin-resistant Staphylococcus aureus (MRSA) are prevalent in the emergency department (ED). We determined whether MRSA nasal carriage better identifies patients with MRSA wound infection than clinical risk factors or emergency medicine (EM) provider's choice of discharge prescriptions. METHODS: Adult patients presenting to a large academic medical centre ED in the USA with SSTI between May 2010 and November 2011 were screened...
March 9, 2018: Emergency Medicine Journal: EMJ
Nicole Bertin, Gabriele Brosolo, Fabrizio Pistola, Francesco Pelizzo, Christian Marini, Franco Pertoldi, Olga Vriz
BACKGROUND: Capnocytophaga canimorsus is a bacterium of the normal oral flora of dogs and cats. Human infection is caused by animal bite but is rarely observed, mainly in immunocompromised patients. We present 2 cases of C. canimorsus infection that occurred in immunocompetent patients and caused multiorgan failure and in both cases severe neurologic involvement. CASE REPORT: In the first case, we present a 69-year-old immunocompetent woman with septic shock derived from skin and soft tissue infection after a dog's bite...
March 6, 2018: Journal of Emergency Medicine
Patrick Reich, Thomas Shute, Colleen Lysen, Shawn R Lockhart, M Kelly Keating, Philip Custer, Rachel Orscheln
An 11-year-old immunocompetent girl presented with two and a half months of progressive right orbital cellulitis, which did not respond to multiple courses of antibiotics or prednisone. A panfungal polymerase chain reaction primer was positive for Saksenaea vasiformis, and she completed 5 months of oral posaconazole therapy after debridement. Saksenaea vasiformis is a rare cause of zygomycosis, and it typically causes skin and soft tissue infection in immunocompetent hosts, particularly after a traumatic injury...
March 7, 2018: Journal of the Pediatric Infectious Diseases Society
S S Almarzoky Abuhussain, K J Goodlet, M D Nailor, D P Nicolau
Skin and skin structure infections (SSSIs) refer to a collection of clinical infectious syndromes involving layers of skin and associated soft tissues. Although associated with less morbidity and mortality than other common skin infections, SSSIs represent a significant increasing source of healthcare expense, with a prevalence of 500 episodes per 10,000 patient-years in the United States resulting in burdening health care systems, of approximately $6 billion annually. Areas covered: Opportunities to reduce costs of care associated with SSSI are highlighted, including transitions of care and avoiding unnecessary hospital admissions...
March 9, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
Silvia Seibt, Catherine A Gilchrist, Peter W Reed, Emma J Best, Anthony Harnden, Carlos A Camargo, Cameron C Grant
BACKGROUND: Infectious diseases are the leading cause of hospital admissions in young children. Hospitalisation with an infectious disease is a recurrent event for some children. Our objective was to describe risk factors for infectious disease readmission following hospital admission with an infectious disease in the first two years of life. METHODS: We performed a national cohort study of New Zealand children, born 2005-2009, with an infectious disease admission before age 24 months...
March 5, 2018: BMC Pediatrics
Il Hoon Sung, Dong Woo Jang, Se Wan Kim, Youn Hwan Kim, Sang Wha Kim
BACKGROUND: Reconstruction of complicated diabetic lower leg and foot defects involving multiple tissue components remains a challenge. The purpose of this report is to introduce thoracodorsal artery perforator (TDAP) chimeric flaps for reconstructing diabetic lower leg and foot soft tissue defects. PATIENTS AND METHODS: Between April 2010 and August 2016, 17 patients with multiple diabetic lower leg and foot defects underwent reconstruction with TDAP chimeric flaps...
March 5, 2018: Microsurgery
Kordo Saeed, Silvano Esposito, Ian Gould, Tiziana Ascione, Matteo Bassetti, Eric Bonnet, Emilio Bouza, Monica Chan, Joshua S Davis, Giuseppe De Simone, Matthew Dryden, Thomas Gottlieb, Karolin Hijazi, David C Lye, Pasquale Pagliano, Christina Petridou, Elda Righi, John Segreti, Serhet Unal, Ata Nevzat Yalcin
No abstract text is available yet for this article.
February 28, 2018: International Journal of Antimicrobial Agents
Hichem Bargui, Manel Marzouk, Ahmed Benhadj, Moufida Hadj Ali, Youssef Ben Salem, Jalel Boukadida
OBJECTIVE: To present the clinical and bacteriological characteristics of human Aeromonas infections in the central region of Tunisia from January 2011 to September 2015. METHODS: Retrospective study concerning all Aeromonas spp strains isolated at our laboratory during a period of 5 years (2011-2015). Following data were collected: gender, age, hospital department, co-morbidities, site of infection, date, the Aeromonas species and susceptibility phenotype. Identification was based on conventional criteria and antibiotic susceptibility was performed according to the recommendations of "the Committee of the French Society of Microbiology...
April 2017: La Tunisie Médicale
Lina María Castaño-Jaramillo, C Beltrán-Arroyave, L C Santander-Peláez, A M Vélez-Escobar, C G Garcés-Samudio, Mónica Trujillo-Honeysberg
BACKGROUND: Skin and soft tissue infections (SSTI) are very common in children and Staphylococcus aureus is the main agent, with an increase of methicillin resistant strains (MRSA) in recent years. AIM: To identify the frequency of MRSA in skin and soft tissue infections (SSTI) in children from a high complex hospital in Medellin, Colombia. METHODS: This is a descriptive, retrospective study, information was obtained from medical records. We included patients younger than 18 years with SSTI due to S...
October 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Rondi B Gelbard, Paula Ferrada, D Dante Yeh, Brian Williams, Michele Loor, James Yon, Caleb Mentzer, Kosar Khwaja, Mansoor Khan, Anirudh Kohli, Eileen M Bulger, Bryce R H Robinson
BACKGROUND: Necrotizing soft tissue infections (NSTI) are rare, life-threatening, soft-tissue infections characterized by rapidly spreading inflammation and necrosis of the skin, subcutaneous fat, and fascia. While it is widely accepted that delay in surgical debridement contributes to increased mortality, there are currently no practice management guidelines regarding the optimal timing of surgical management of this condition. Although debridement within 24 hours of diagnosis is generally recommended, the time ranges from 3 hours to 36 hours in the existing literature...
February 27, 2018: Journal of Trauma and Acute Care Surgery
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