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Skin and soft tissue infections

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https://www.readbyqxmd.com/read/29158645/evaluation-of-functional-outcome-of-pilon-fractures-managed-with-limited-internal-fixation-and-external-fixation-a-prospective-clinical-study
#1
Umesh Kumar Meena, Mahesh Chand Bansal, Prateek Behera, Rahul Upadhyay, Gyan Chand Gothwal
Introduction: The management of pilon fractures is controversial primarily due to the high rate of complications irrespective of the mode of treatment. Limited internal fixation with external fixation is associated with minimal soft tissue handling. This may reduce the chances of wound dehiscence and infection. This study was designed to evaluate the functional and clinical outcomes in patients treated with limited internal fixation combined with external fixation in pilon fractures. Material and methods: This study was conducted as a prospective clinical study on 56 skeletally mature patients with closed fractures with poor skin condition, and with open grade 1 and grade 2 distal tibial intra-articular fractures...
November 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29158144/ceftolozane-tazobactam-in-the-treatment-of-osteomyelitis-and-skin-and-soft-tissue-infections-due-to-extensively-drug-resistant-pseudomonas-aeruginosa-clinical-and-microbiological-outcomes
#2
B Dietl, I Sánchez, P Arcenillas, E Cuchi, L Gómez, F J González de Molina, L Boix-Palop, J Nicolás, E Calbo
Infections due to multidrug-resistant bacteria (MDRB) are currently a clinical challenge, mainly in elderly patients. Ceftolozane/tazobactam spectrum, safety and efficacy make it an attractive option for MDRB beyond the indications approved to date. We report our experience with ceftolozane/tazobactam in 4 cases of osteomyelitis and 3 skin-soft-tissue infections due to extensively-drug-resistant Pseudomonas aeruginosa.
November 17, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29157827/supplementation-with-tocotrienols-from-bixa-orellana-improves-the-in-vivo-efficacy-of-daptomycin-against-methicillin-resistant-staphylococcus-aureus-in-a-mouse-model-of-infected-wound
#3
Elisa Pierpaoli, Fiorenza Orlando, Oscar Cirioni, Oriana Simonetti, Andrea Giacometti, Mauro Provinciali
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of skin and soft-tissue infection worldwide. An adequate immune response acts as a first line of defence against infections and therefore plays an essential role in the maintenance of health. Tocotrienols (T3s), the lesser known isomers of vitamin E, possess many biological properties and have been recognized as immunomodulators. PURPOSE: The aim of this study was to investigate whether the in vivo supplementation with a mixture of 87...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29154746/in-vitro-and-in-vivo-activity-of-fosfomycin-alone-and-in-combination-with-rifampin-and-tigecycline-against-gram-positive-cocci-isolated-from-surgical-wound-infections
#4
Oriana Simonetti, Gianluca Morroni, Roberto Ghiselli, Fiorenza Orlando, Andrea Brenciani, Ledia Xhuvelaj, Mauro Provinciali, Annamaria Offidani, Mario Guerrieri, Andrea Giacometti, Oscar Cirioni
Complicated skin and soft tissue infections constitute a heterogeneous group of severe disorders, with surgical site infections being the most common hospital-acquired ones. The aim of our study was to investigate the synergistic and bactericidal activities of antimicrobial combinations of fosfomycin with rifampicin and tigecycline against Enterococcus faecalis, Enterococcus faecium and methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates, and also to evaluate their in vivo effects in a mouse wound infection model...
November 20, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29149266/association-between-prior-antibiotic-therapy-and-subsequent-risk-of-community-acquired-infections-a-systematic-review
#5
Umer Malik, David Armstrong, Mark Ashworth, Alex Dregan, Veline L'Esperance, Lucy McDonnell, Mariam Molokhia, Patrick White
Background: Antibiotic use can have negative unintended consequences including disruption of the human microbiota, which is thought to protect against pathogen overgrowth. We conducted a systematic review to assess whether there is an association between exposure to antibiotics and subsequent risk of community-acquired infections. Methods: We searched MEDLINE, EMBASE and Web of Science for studies published before 30 June 2017, examining the association between antibiotic use and subsequent community-acquired infection...
November 14, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29124834/prevalence-and-characterization-of-staphylococcus-aureus-causing-community-acquired-skin-and-soft-tissue-infections-on-java-and-bali-indonesia
#6
Dewi Santosaningsih, Sanarto Santoso, Nanik Setijowati, Harun A Rasyid, Nyoman S Budayanti, Ketut Suata, Dicky B Widhyatmoko, Priyo B Purwono, Kuntaman Kuntaman, Damayanti Damayanti, Cita R S Prakoeswa, Mitchell Laurens, Josephine W I van Nierop, Geraldine L Nanninga, Neline Oudenes, Michelle de Regt, Susan V Snijders, Henri A Verbrugh, Juliëtte A Severin
OBJECTIVES: To define the role of Staphylococcus aureus in community settings among patients with skin and soft tissue infections (SSTI) in Indonesia. METHODS: S. aureus were cultured from anterior nares, throat, and wounds of 567 ambulatory patients presenting with SSTI. The mecA gene and genes encoding Panton-Valentine leukocidin (PVL; lukF-PV and lukS-PV) and exfoliative toxin (ET; eta and etb) were determined by PCR. Clonal relatedness among methicillin-resistant S...
November 10, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29110982/point-of-care-ultrasound-is-associated-with-decreased-length-of-stay-in-children-presenting-to-the-emergency-department-with-soft-tissue-infection
#7
Margaret J Lin, Mark Neuman, Rachel Rempell, Michael Monuteaux, Jason Levy
BACKGROUND: Point-of-care ultrasound (POCUS) is increasingly being used to differentiate cellulitis from abscess in the pediatric emergency department (ED). POCUS has also been shown to decrease length of stay (LOS) for other applications among adult patients. OBJECTIVE: We sought to determine if ED LOS differed for children presenting with skin and soft tissue infections who received POCUS versus radiology-performed ultrasound. METHODS: We performed a retrospective cohort study of children presenting to an urban pediatric ED between January 2011 and June 2013 with a diagnosis of cellulitis or abscess who underwent soft tissue ultrasound...
October 27, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29107417/osteoarticular-and-skin-and-soft-tissue-infections-caused-by-streptococcus-agalactiae-in-elderly-patients-are-frequently-associated-with-bacteremia
#8
Corinne Ruppen, Julia Notter, Carol Strahm, Beat Sonderegger, Parham Sendi
Older persons (≥65 years) are at risk for invasive group B streptococcal (GBS) infections. The most frequent clinical syndromes in 174 infection episodes were osteoarticular (40%) and skin and soft-tissue infections (30%). In 36% of episodes, a companion microorganism was isolated, and in 45%, blood culture results were positive. Antibiotics were streamlined after species identification in 29% of monomicrobial infections. These findings have clinical and therapeutic implications for GBS infections in the elderly...
September 19, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29102120/antimicrobial-resistance-in-clinical-escherichia-coli-isolated-from-companion-animals-in-australia
#9
Sugiyono Saputra, David Jordan, Tahlia Mitchell, Hui San Wong, Rebecca J Abraham, Amanda Kidsley, John Turnidge, Darren J Trott, Sam Abraham
Multidrug-resistant (MDR) Escherichia coli have become a major public health concern to both humans and animal health. While the frequency of antimicrobial resistance (AMR) in clinical E. coli is monitored regularly in human medicine, current frequency of AMR in companion animals remains unknown in Australia. In this study we conducted antimicrobial susceptibility testing (AST) and where possible, determined potential risk factors for MDR infection among 883 clinical Escherichia coli isolated from dogs (n=514), cats (n=341) and horses (n=28)...
November 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29101576/trends-in-community-versus-health-care-acquired-methicillin-resistant-staphylococcus-aureus-infections
#10
REVIEW
David P Calfee
Since the first clinical isolate of methicillin-resistant Staphylococcus aureus was described in 1961, this pathogen has established itself as a leading cause of health care-associated infections. More recently, MRSA has become a relatively common cause of infection among persons without typical health care-associated risk factors and is now the most common cause of community-onset purulent skin and soft-tissue infections in many regions of the USA. The appearance of "community-associated" MRSA is not due to the expansion of health care-associated MRSA into the community but rather the result of the independent emergence of a novel clone of MRSA...
November 3, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29094435/the-burden-of-common-infections-in-children-and-adolescents-with-diabetes-mellitus-a-pediatric-health-information-system-study
#11
Lindsey Korbel, Robert S Easterling, Nidhi Punja, John David Spencer
BACKGROUND: People with diabetes mellitus (DM) have increased infection risk. The healthcare utilization of pediatric and adolescent diabetic patients with infection is not well defined. This study evaluates the number of pediatric and adolescent patients with DM that seek medical treatment for infection management and assesses its socioeconomic impact. METHODS: A retrospective analysis was performed using the Pediatric Health Information System (PHIS) database on children and adolescents with DM who presented to the Emergency Department (ED) or were hospitalized for infection management from 2008 to 2014...
November 2, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29091186/antimicrobial-resistance-in-mycobacterium-abscessus-complex-isolated-from-patients-with-skin-and-soft-tissue-infections-at-a-tertiary-teaching-hospital-in-taiwan
#12
Ming-Chun Lee, Pei-Lun Sun, Tsu-Lan Wu, Li-Hsin Wang, Chih-Hsun Yang, Wen-Hung Chung, An-Jing Kuo, Tsui-Ping Liu, Jang-Jih Lu, Cheng-Hsun Chiu, Hsin-Chih Lai, Nan-Yu Chen, Jeng-How Yang, Ting-Shu Wu
Background: Mycobacterium abscessus complex (MABC) is the most common non-tuberculous mycobacterium that causes complicated skin and soft tissue infections (cSSTIs). The selection of antimycobacterial agents for successful treatment of such infections is a critical issue. Objectives: To investigate the antimicrobial susceptibility patterns of MABC isolates from skin and soft tissue to a variety of antimycobacterial agents. Methods: Sixty-seven MABC isolates were collected and partial gene sequencing of secA1, rpoB and hsp65 was used to classify them into three subspecies: M...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29090420/soft-tissue-infection-secondary-to-cellulitis-killed-st-john-of-the-cross-1542-1591
#13
Raffaella Bianucci, Otto Appenzeller, Peter Evans, Philippe Charlier, Antonio Perciaccante
PURPOSE: St. John of the Cross (1542-1591) died aged 49 years after 3 months of excruciating pain following a trivial lesion in his right foot. Erysipelas, a superficial bacterial infection of the skin, and subsequent sepsis were previously suggested as the cause of his death. Here, an alternative diagnosis is proposed. METHODS: An accurate perusal of his biography allowed the symptomatology, the clinical evolution, the depth of the infection and the associated systemic manifestations displayed by Fray John to be reconstructed...
October 31, 2017: Infection
https://www.readbyqxmd.com/read/29089730/clinical-presentation-of-soft-tissue-infections-and-its-management-a-study-of-100-cases
#14
Baldev Singh, Sukha Singh, Sudhir Khichy, Avinash Ghatge
BACKGROUND: Soft-tissue infections vary widely in their nature and severity. A clear approach to the management must allow their rapid identification and treatment as they can be life-threatening. OBJECTIVE: Clinical presentation of soft-tissue infections and its management. MATERIALS AND METHODS: A prospective study based on 100 patients presenting with soft-tissue infections was done. All the cases of soft-tissue infections were considered irrespective of age, sex, etiological factors, or systemic disorders...
July 2017: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/29082520/necrotizing-soft-tissue-infections-a-multicentre-prospective-observational-study-infect-protocol-and-statistical-analysis-plan
#15
M B Madsen, S Skrede, T Bruun, P Arnell, A Rosén, M Nekludov, Y Karlsson, F Bergey, E Saccenti, V A P Martins Dos Santos, A Perner, A Norrby-Teglund, O Hyldegaard
BACKGROUND: The INFECT project aims to advance our understanding of the pathophysiological mechanisms in necrotizing soft tissue infections (NSTIs). The INFECT observational study is part of the INFECT project with the aim of studying the clinical profile of patients with NSTIs and correlating these to patient-important outcomes. With this protocol and statistical analysis plan we describe the methods used to obtain data and the details of the planned analyses. METHODS: The INFECT study is a multicentre, prospective observational cohort study...
October 29, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29082050/a-case-of-rituximab-induced-necrotizing-fasciitis-and-a-review-of-the-literature
#16
Abdullateef Abdulkareem, Ryan S D'Souza, Oluwaseun Shogbesan, Anthony Donato
Necrotizing fasciitis is a fulminant soft tissue infection characterized by rapid progression and high mortality. Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic lymphocytic leukemia who suffered necrotizing fasciitis of his left lower extremity secondary to Clostridium septicum 7 weeks after treatment with rituximab. Despite immediate intravenous antimicrobial therapy and emergent fasciotomy with extensive debridement, his hospital course was complicated by septic shock and he required an above-the-knee amputation...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/29079067/clinical-mimics-an-emergency-medicine-focused-review-of-cellulitis-mimics
#17
Garrett Blumberg, Brit Long, Alex Koyfman
BACKGROUND: Cellulitis is a common clinical condition with low rates of morbidity and mortality if treated appropriately. Mimics of cellulitis presenting with erythema, edema, warmth, and pain can be associated with grave morbidity and mortality if misdiagnosed. OBJECTIVE: This review investigates the signs and symptoms of cellulitis, mimics of cellulitis, and an approach to the management of both cellulitis and its mimics. DISCUSSION: The current emergency medicine definition of cellulitis includes erythema, induration, warmth, and swelling...
October 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29074158/staphylococcus-aureus-colonization-during-military-service-a-prospective-cohort-study
#18
Hege Vangstein Aamot, Petri Kaarlo Juhani Eskonsipo, Silje Bakken Jørgensen, Anita Blomfeldt
OBJECTIVES: Staphylococcus aureus colonization leading to skin and soft tissue infections (SSTI) are known challenges in crowded settings such as the military. The aim of the study was to a) establish and compare the prevalence of S. aureus colonization in recruits at enrolment and discharge after the first year of military service and b) investigate the prevalence of S. aureus SSTI. METHODS: All recruits entering first year of military service in January 2013 to be stationed at three garrisons in the northern part of Norway were invited to join this prospective cohort study...
October 23, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29071377/-plate-osteosynthesis-of-patellar-fractures
#19
REVIEW
E C Müller, K-H Frosch
OBJECTIVE: Anatomic reconstruction of the retropatellar articular surface and repair of the extensor mechanism of the knee joint. The osteosynthesis should allow immediate mobilization as part of an early functional postoperative rehabilitation protocol. INDICATIONS: Displaced fractures of the patella, especially multifragment and comminuted fractures with a retropatellar incongruity or dislocation of >2 mm. CONTRAINDICATIONS: Critical local soft tissue because of the risk of postoperative infection...
October 25, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29069651/staphylococcus-aureus-%C3%AE-toxin-induces-inflammatory-cytokines-via-lysosomal-acid-sphingomyelinase-and-ceramides
#20
Jie Ma, Erich Gulbins, Michael J Edwards, Charles C Caldwell, Martin Fraunholz, Katrin Anne Becker
BACKGROUND/AIMS: Staphylococcus aureus (S. aureus) infections are a major clinical problem and range from mild skin and soft-tissue infections to severe and even lethal infections such as pneumonia, endocarditis, sepsis, osteomyelitis, and toxic shock syndrome. Toxins that are released from S. aureus mediate many of these effects. Here, we aimed to identify molecular mechanisms how α-toxin, a major S. aureus toxin, induces inflammation. METHODS: Macrophages were isolated from the bone marrow of wildtype and acid sphingomyelinase-deficient mice, stimulated with S...
October 25, 2017: Cellular Physiology and Biochemistry
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