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Skin and soft tissue infections

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https://www.readbyqxmd.com/read/28722566/molecular-epidemiology-of-staphylococcus-aureus-skin-and-soft-tissue-infections-in-the-lao-people-s-democratic-republic
#1
Alicia D Yeap, Kate Woods, David A B Dance, Bruno Pichon, Sayaphet Rattanavong, Viengmon Davong, Rattanaphone Phetsouvanh, Paul N Newton, Nandini Shetty, Angela M Kearns
This is the first report of the molecular epidemiology of Staphylococcus aureus from skin and soft tissue infections (SSTI) in Laos. We selected a random sample of 96 S. aureus SSTI isolates received by the Microbiology Laboratory, Mahosot Hospital, Vientiane, between July 2012 and June 2014, including representation from seven referral hospitals. Isolates underwent susceptibility testing by Clinical and Laboratory Standards Institute methods, spa typing and DNA microarray analysis, with whole genome sequencing for rare lineages...
May 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28717038/a-human-biofilm-disrupting-monoclonal-antibody-potentiates-antibiotic-efficacy-in-rodent-models-of-both-staphylococcus-aureus-and-acinetobacter-baumannii-infections
#2
Yan Q Xiong, Angeles Estellés, L Li, W Abdelhady, R Gonzales, Arnold S Bayer, Edgar Tenorio, Anton Leighton, Stefan Ryser, Lawrence M Kauvar
Many serious bacterial infections are antibiotic-refractory due to biofilm formation. A key structural component of biofilm is extracellular DNA which is stabilized by bacterial proteins, including those from the DNABII family. TRL1068 is a high affinity human monoclonal antibody against a DNABII epitope conserved across both gram-positive and gram-negative bacterial species. In the current study, the efficacy of TRL1068 for disruption of biofilm was demonstrated in vitro in the absence of antibiotics by scanning electron microscopy...
July 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28712930/disseminated-mycobacterium-kansasii-infection-with-cutaneous-lesions-in-an-immunocompetent-patient
#3
Miaomiao Zhang, Mei Feng, Jian-Qing He
We reported a case of disseminated Mycobacterium Kansasii (M. kansasii) infections involving skin tissue in a 57-year-old male farmer for recurrent fever, respiratory syndromes and skin lesions. Positive findings of syndromes, laboratory examinations and M. kansasii identified in the puncture fluid indicated the diagnosis of disseminated M. kansasii infections involving skin/soft tissue, pulmonary and mediastinal lymph nodes. After applying the standard HRE regime (isoniazid (300mg/d), rifampicin (600mg/d), and ethambutol (750mg/d)), the patient's temperature normalized and symptoms relieved gradually...
July 13, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28711129/care-of-infectious-conditions-in-an-observation-unit
#4
REVIEW
Pawan Suri, Taruna K Aurora
Infectious conditions such as skin and soft tissue infections (SSTIs), Urogenital infections and peritonsillar abscesses frequently require care beyond emergency stabilization and are well-suited for short term care in an observation unit. SSTIs are a growing problem, partly due to emergence of strains of methicillin-resistant S. aureus (MRSA). Antibiotic choice is guided by the presence of purulence and site of infection. Purulent cellulitis is much more likely to be associated with MRSA. Radiographic imaging should be considered to aid in management in patients who are immunosuppressed, have persistent symptoms despite antibiotic therapy, recurrent infections, sepsis or diabetes...
August 2017: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/28708463/epidemiological-trends-observed-from-molecular-characterization-of-methicillin-resistant-staphylococcus-aureus-isolates-from-blood-cultures-at-a-japanese-university-hospital-2012-2015
#5
Yuri Miura, Tetsuo Yamaguchi, Itaru Nakamura, Shinobu Koyama, Kiyoko Tamai, Takashi Okanda, Tetsuya Matsumoto
Despite increasing reports of skin and soft tissue infections caused by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Japan, the extent to which these strains cause nosocomial infections remains unknown, and this is especially true for bloodstream infections. In this study, we molecularly characterized MRSA isolates from Japanese blood samples. Among the 151 MRSA isolates collected from 53 medical facilities in 2011, 115 (76%) and 30 (20%) were classified as staphylococcal cassette chromosome mec (SCCmec) types II and IV, respectively, while the Panton-Valentine leukocidin (PVL) gene was detected in only two isolates...
July 14, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28706447/treatment-patterns-resource-utilization-and-outcomes-among-hospitalized-patients-with-methicillin-resistant-staphylococcus-aureus-complicated-skin-and-soft-tissue-infections-in-lebanon-and-saudi-arabia
#6
Madonna J Matar, Rima Moghnieh, Adel F Alothman, Abdulhakeem O Althaqafi, Thamer H Alenazi, Fayssal M Farahat, Shelby Corman, Caitlyn T Solem, Nirvana Raghubir, Cynthia Macahilig, Seema Haider, Jennifer M Stephens
OBJECTIVES: To describe treatment patterns and medical resource use for methicillin-resistant Staphylococcus aureus (MRSA) complicated skin and soft tissue infections (cSSTI) in Saudi Arabia and Lebanon in terms of drug selection against the infecting pathogen as well as hospital resource utilization and clinical outcomes among patients with these infections. METHODS: This retrospective chart review study evaluated 2011-2012 data from five hospitals in Saudi Arabia and Lebanon...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28705427/invasive-disease-by-streptococcus-pyogenes-patients-hospitalized-for-6-years
#7
Vanessa Arias-Constantí, Victoria Trenchs-Sainz de la Maza, Nuria Elvira Sanz-Marcos, Carmina Guitart-Pardellans, Amadeu Gené-Giralt, Carles Luaces-Cubells
INTRODUCTION AND OBJECTIVE: The last years an increase of severe cases of invasive disease (ID) due to Streptococcus pyogenes or streptococcus b-hemolytic group A (SGA) had been detected. The aim of this study was to analyze the epidemiology and the clinical features of ID due to SGA in a tertiary Pediatric Hospital. MATERIAL AND METHODS: Retrospective study in a Pediatric hospital, of all in-patients with final diagnosis of ID due to SGA during 6 years (2009-2014)...
July 10, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28705150/economic-burden-of-varicella-in-children-1-12%C3%A2-years-of-age-in-hungary-2011-2015
#8
Z Meszner, Z Molnar, E Rampakakis, H K Yang, B J Kuter, Lara J Wolfson
BACKGROUND: Although live-attenuated varicella-zoster virus (VZV) vaccines have been proven to be safe and effective in preventing varicella and real-word evidence shows routine childhood immunization programs are effective in dramatically reducing varicella associated morbidity and mortality, varicella vaccine is not included in the National Immunization Program (NIP) in Hungary. The purpose of this study was to evaluate the clinical and economic burden associated with varicella in Hungary...
July 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28701438/community-associated-methicillin-resistant-staphylococcus-aureus-infection-literature-review-and-clinical-update
#9
REVIEW
Kassandra Loewen, Yoko Schreiber, Mike Kirlew, Natalie Bocking, Len Kelly
OBJECTIVE: To provide information on the prevalence and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections and the distinction between community-associated MRSA and health care-associated MRSA. QUALITY OF EVIDENCE: The MEDLINE and EMBASE databases were searched from 2005 to 2016. Epidemiologic studies were summarized and the relevant treatment literature was based on level I evidence. MAIN MESSAGE: The incidence of community-associated MRSA infection is rising...
July 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28698756/treatment-of-decubitis-ulcer-stage-iv-in-the-patient-with-polytrauma-and-vertical-share-pelvic-fracture-diagnosed-entherocollitis-and-deep-wound-infection-with-clostridium-difficile-with-combined-negative-pressure-wound-therapy-npwt-and-faecal-management-system
#10
Slavcho Stojmenski, Igor Merdzanovski, Andrej Gavrilovski, Sofija Pejkova, Gjorge Dzokic, Smilja Tudzarova
AIM: The aim of this paper was to present a case with the successful treatment of decubitis ulcer stage IV in the patient with polytrauma and vertical share pelvic fracture and diagnosed entherocollitis combined with deep wound infection with Clostridium difficile treated with combined Negative Pressure Wound Therapy (NPWT) and faecal management system. CASE REPORT: Patient D.S.1967 treated on Traumatology Clinic after tentamen suicide on 9.2.2015 with diagnosis: brain contusion; contusion of thoracal space; vertical share pelvic fracture; open fracture type II of the right calcaneus; fracture of the left calcaneus; fracture on the typical place of the left radius; fracture of the right radius with dislocation...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28697851/incidence-and-effects-of-seasonality-on-nonpurulent-lower-extremity-cellulitis-after-the-emergence-of-community-acquired-methicillin-resistant-staphylococcus-aureus
#11
Jasmine R Marcelin, Douglas W Challener, Eugene M Tan, Brian D Lahr, Larry M Baddour
Nonpurulent lower extremity cellulitis (NLEC) is a common clinical diagnosis, with β-hemolytic streptococci and Staphylococcus aureus considered to be the most frequent causes. In 1999, the US Public Health Service alerted clinicians to the presence of community-acquired methicillin-resistant S aureus (CA-MRSA) infections in 4 children in the upper Midwest. Since then, it has become a well-recognized cause of skin and soft-tissue infections, in particular, skin abscess. A previous population-based study of NLEC in Olmsted County, Minnesota, reported an unadjusted incidence rate of 199 per 100,000 person-years in 1999, but it is unknown whether CA-MRSA subsequently has affected NLEC incidence...
July 8, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28697269/pediatric-cellulitis-a-red-hot-concern
#12
Andrew Shriner, Laurie Wilkie
Cellulitis and other skin and soft tissue infections are a common reason for children to seek care, both in the primary care setting and the emergency department. Cellulitis is a common skin and soft-tissue infection that is usually caused by streptococci bacteria or, less commonly, Staphylococcus aureus. Most children recover quickly from cellulitis, but a small subset will require hospitalization. Practitioners need to be skilled in the diagnosis and treatment of cellulitis, including recognition of the need for inpatient treatment...
July 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28695181/prepping-the-knee-in-maximal-flexion-getting-into-every-nook-cranny-and-fold
#13
Peter A Knoll, James A Browne
This article describes a simple surgical skin preparation technique for total knee arthroplasty that permits the application of skin prep agent with the knee in maximal flexion. While most surgeons prep the knee in extension, it is believed that prep of the knee in flexion will provide superior coverage of the skin surface and reduce the potential for surgical-site infection, particularly in obese patients with large soft-tissue layers anterior to the knee.
June 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/28691475/genetic-effects-of-biopad%C3%A2-on-fibroblast-primary-culture
#14
A Baj, G A Beltramini, M Romano, D Lauritano, R M Gaudio, A Palmieri, F Cura, A B Giannì
BIOPAD® is an ivory-white soft sponge, made exclusively of lyophilized type I native heterologous collagen extracted from horse flexor tendon, gelatine free, that keeps its native structure specific to the body’s skin tissue. BIOPAD® is an active dressing, playing an active role in all stages of wound healing process, stimulating granulation tissue growth and enhancing regeneration tissues. It ensures balance between absorption and humidity at wound surface, gaseous exchange of soft tissues during healing process, barrier to prevent bacterial infections and it is completely non-adherent...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28683717/role-of-outpatient-parenteral-antibiotic-therapy-in-the-treatment-of-community-acquired-skin-and-soft-tissue-infections-in-singapore
#15
Monica Chan, Chee Kheong Ooi, Joshua Wong, Lihua Zhong, David Lye
No abstract text is available yet for this article.
July 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28683356/scintigraphic-imaging-of-staphylococcus-aureus-infection-using-99m-tc-radiolabeled-aptamers
#16
Sara Roberta Dos Santos, Camila Maria de Sousa Lacerda, Iêda Mendes Ferreira, André Luís Branco de Barros, Simone Odília Fernandes, Valbert Nascimento Cardoso, Antero Silva Ribeiro de Andrade
Staphylococcus aureus is a specie of great medical importance associated with many infections as bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device related infections. Early identification of infectious foci is crucial for successful treatment. Scintigraphy could contribute to this purpose since specific radiotracers were available. Aptamers due to their high specificity have great potential for radiopharmaceuticals development. In the present study scintigraphic images of S...
June 28, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28682290/prolonged-allograft-survival-in-a-patient-with-chronic-immunosuppression-a-case-report-and-systematic-review
#17
Krishna S Vyas, Chase Burns, Dylan T Ryan, Lesley Wong
A 41-year-old man with past medical history of kidney-liver transplantation requiring chronic immunosuppression presented 2 years posttransplant with a necrotizing soft tissue infection of his right thigh. Serial debridement to remove necrotic tissue was performed, and a Matrix HD Allograft Fenestrated (RTI Surgical, Alachua, FL) was applied. At 5-months post grafting, the patient demonstrated fully vascularized and intact skin. Under normal circumstances, a cadaveric allograft sloughs over several weeks and is not usually considered a permanent solution for wound closure...
June 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28673610/clinical-efficacy-cost-analysis-and-patient-acceptability-of-outpatient-parenteral-antibiotic-therapy-opat-a-decade-of-sheffield-uk-opat-service
#18
Oyewole Christopher Durojaiye, Helen Bell, Dawn Andrews, Fotinie Ntziora, Katharine Cartwright
Outpatient parenteral antimicrobial therapy (OPAT) has evolved relatively slowly in the UK. This study describes the OPAT service based in a large UK teaching hospital in Sheffield, and examines the clinical efficacy, patient acceptability and costs saved over a 10-year period. Data on 3812 episodes of OPAT treatment administered between January 2006 and January 2016 were retrieved from a prospectively maintained electronic database. This study compared the real costs of the OPAT service with estimated costs of conventional inpatient care for these patient episodes, and analysed patient feedback questionnaires that were administered randomly between January 2014 and January 2015...
June 30, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28671898/patterns-and-outcomes-associated-with-timeliness-of-initial-crystalloid-resuscitation-in-a-prospective-sepsis-and-septic-shock-cohort
#19
Daniel E Leisman, Chananya Goldman, Martin E Doerfler, Kevin D Masick, Susan Dries, Eric Hamilton, Mangala Narasimhan, Gulrukh Zaidi, Jason A D'Amore, John K D'Angelo
OBJECTIVES: The objectives of this study were to 1) assess patterns of early crystalloid resuscitation provided to sepsis and septic shock patients at initial presentation and 2) determine the association between time to initial crystalloid resuscitation with hospital mortality, mechanical ventilation, ICU utilization, and length of stay. DESIGN: Consecutive-sample observational cohort. SETTING: Nine tertiary and community hospitals over 1...
June 30, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28671777/-cutaneous-infections-in-the-emergency-department-the-devil-in-the-detail
#20
Ioanna Chrysogelou, Olivier Clerc, Vincent Della Santa
Skin and soft tissue infections, which are a common cause of admission, are characterized by a clinical polymorphism leading to diagnostic errors. To a certain point, confusion exists between used terms and indicated treatment, especially since the emergence of methicillin-resistant Staphylococcus aureus (MRSA) infections.The paucity of cutaneous findings early in the course of deep soft tissue infections makes diagnosis challenging for physicians in charge. Some of these infections are warranted to achieve a lower mortality and morbidity by the administration of effective surgical treatment...
August 10, 2016: Revue Médicale Suisse
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