keyword
https://read.qxmd.com/read/38335838/the-role-of-oligoclonal-band-count-and-igg-index-in-treatment-response-and-disease-activity-in-multiple-sclerosis
#21
JOURNAL ARTICLE
Esra Taşkıran, Murat Terzi, Elif Merve Helvacı, Meltem Zeycan Eser, Bahattin Avcı, Turan Ömer Faruk, Mehmet Fatih Yetkin, Vedat Çilingir, Levent Sinan Bir, Sibel Canbaz Kabay, Nuray Bilge, Turan Poyraz, Caner Feyzi Demir, Dilcan Kotan Dündar, Özgül Ocak, Mustafa Çam, Hatice Mavioğlu, Yaşar Altun, Adnan Karaibrahimoğlu
BACKGROUND/AIM: Multiple sclerosis (MS) is an inflammatory demyelinating central nervous system (CNS) disease. Among the paraclinical tests, brain and spinal Magnetic Resonance Imaging (MRI) is primarily involved in the diagnosis process, and cerebrospinal fluid (CSF) analysis is fundamental in diagnosing MS and the differential diagnosis. A positive relationship was demonstrated between oligoclonal band (OCB) positivity, CSF band number and immunoglobulin G(IgG) index. The study aimed to evaluate whether the number of OCB can predict disease activity and determine a correlation with the IgG index...
March 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38317810/association-of-rs7217186-polymorphism-of-arachidonic-acid-15-lipoxygenase-alox15-gene-with-susceptibility-to-allergic-rhinitis
#22
JOURNAL ARTICLE
Atefeh Eivazi, Bahman Akbari, Sara Falahi, Ali Gorgin Karaji, Alireza Rezaiemanesh, Seyed Hamid Reza Mortazavi, Niloofar Daneshfar, Farhad Salari
BACKGROUND: Allergic rhinitis (AR) is an inflammatory disorder of the nasal mucosa, caused by exposure to environmental allergens. It is known that 15-lipoxygenase (15-LOX) is involved in the biosynthetic pathways of anti-inflammatory lipid mediators, including resolvins and protectins. METHODS: In this study, which was performed on 130 AR patients and 130 healthy controls, we aimed to investigate the association of susceptibility to AR with two selected single-nucleotide polymorphisms (SNPs), that is, rs2619112:A>G and rs7217186:C>T, in the intron regions of arachidonic acid 15-LOX ( ALOX15 ) gene, using SNPinfo and Regulome DB tools...
July 2023: Reports of Biochemistry & Molecular Biology
https://read.qxmd.com/read/38302945/combining-proteins-with-n-3-pufas-epa%C3%A2-%C3%A2-dha-and-their-inflammation-pro-resolution-mediators-for-preservation-of-skeletal-muscle-mass
#23
REVIEW
Renée Blaauw, Philip C Calder, Robert G Martindale, Mette M Berger
The optimal feeding strategy for critically ill patients is still debated, but feeding must be adapted to individual patient needs. Critically ill patients are at risk of muscle catabolism, leading to loss of muscle mass and its consequent clinical impacts. Timing of introduction of feeding and protein targets have been explored in recent trials. These suggest that "moderate" protein provision (maximum 1.2 g/kg/day) is best during the initial stages of illness. Unresolved inflammation may be a key factor in driving muscle catabolism...
February 1, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38294335/assessment-of-second-primary-malignancies-among-treated-and-untreated-patients-with-chronic-lymphocytic-leukemia-using-real-world-data-from-the-usa
#24
REVIEW
Sikander Ailawadhi, Arliene Ravelo, Carmen D Ng, Bonny Shah, Neil Lamarre, Rongrong Wang, Katherine Eakle, Juliana Ml Biondo
Aim: Improved management of chronic lymphocytic leukemia (CLL) has resulted in a growing population of CLL survivors; these patients have a higher risk of developing second primary malignancies (SPMs) versus the general population. This retrospective cohort study aims to assess the timing, frequency, incidence and types of SPMs in treated and untreated patients with CLL in the USA, using the Surveillance, Epidemiology, and End Results (SEER) Medicare database, which links a nationally representative cancer registry with Medicare claims data...
January 31, 2024: Journal of Comparative Effectiveness Research
https://read.qxmd.com/read/38284127/effectiveness-and-risk-of-second-primary-malignancies-after-radiotherapy-in-major-salivary-gland-carcinomas-a-retrospective-study-using-seer-database
#25
JOURNAL ARTICLE
Yuan Feng, Kai Qian, Kai Guo, Yuan Shi, Jiaqing Zhou, Zhuoying Wang
OBJECTIVE: To investigate the effectiveness of radiotherapy and its association with second primary malignancies (SPMs) risk in major salivary gland carcinomas (MSGCs) patients. METHODS: Cohort 1 included 7274 surgically treated MSGC patients from the Surveillance, Epidemiology, and End Results database, assessing the effectiveness of radiotherapy. Cohort 2 (n = 4213) comprised patients with ≥5-year survival in Cohort 1 to study SPMs. RESULTS: Radiotherapy decreased overall survival in MSGCs patients, but improved it in high-grade MSGCs...
January 29, 2024: Head & Neck
https://read.qxmd.com/read/38283253/macrophages-and-microglia-in-inflammation-and-neuroinflammation-underlying-different-pain-states
#26
JOURNAL ARTICLE
Ouyang Chen, Xin Luo, Ru-Rong Ji
Pain is a main symptom in inflammation, and inflammation induces pain via inflammatory mediators acting on nociceptive neurons. Macrophages and microglia are distinct cell types, representing immune cells and glial cells, respectively, but they share similar roles in pain regulation. Macrophages are key regulators of inflammation and pain. Macrophage polarization plays different roles in inducing and resolving pain. Notably, macrophage polarization and phagocytosis can be induced by specialized pro-resolution mediators (SPMs)...
October 2023: Med Rev (2021)
https://read.qxmd.com/read/38281454/risk-of-secondary-primary-malignancies-in-survivors-of-upper-tract-urothelial-carcinoma-a-nationwide-population-based-analysis
#27
JOURNAL ARTICLE
Kuan-Yu Wu, Ian-Seng Cheong, Jung-Nien Lai, Che-Yuan Hu, Kuo-Chuan Hung, Yi-Ting Chen, Lu-Ting Chiu, Hsin-Tzu Tsai, Yeong-Chin Jou, Tzong-Shin Tzai, Yuh-Shyan Tsai
BACKGROUND: To investigate the cancer types and risk factors of secondary primary malignancy (SPM) in patients with upper tract urothelial carcinoma (UTUC) in Taiwan. METHODS: Using National Health Insurance Research Dataset and catastrophic illness registry, we enrolled newly diagnosed UTUC patients from 2000 to 2013. Those without catastrophic illness registration were excluded from the study. The cancer types and hazard ratios (HRs) of subsequent SPMs were calculated according to the antecedent malignancy...
January 27, 2024: Cancer Epidemiology
https://read.qxmd.com/read/38280539/lipid-mediators-in-glaucoma-unraveling-their-diverse-roles-and-untapped-therapeutic-potential
#28
REVIEW
D J Mathew, J M Sivak
Glaucoma is a complex neurodegenerative disease characterized by optic nerve damage and visual field loss and remains a leading cause of irreversible blindness. Elevated intraocular pressure (IOP) is a critical risk factor that requires effective management. Emerging research underscores dual roles of bioactive lipid mediators in both IOP regulation and the modulation of neurodegeneration/neuroinflammation in glaucoma. Bioactive lipids, encompassing eicosanoids, specialized pro-resolving mediators (SPMs), sphingolipids, and endocannabinoids, have emerged as crucial players in these processes, orchestrating inflammation and diverse effects on aqueous humor dynamics and tissue remodeling...
January 25, 2024: Prostaglandins & Other Lipid Mediators
https://read.qxmd.com/read/38278096/high-temperature-requirement-a1-and-macrophage-migration-inhibitory-factor-in-the-cerebrospinal-fluid-a-potential-marker-of-conversion-from-relapsing-remitting-to-secondary-progressive-multiple-sclerosis
#29
JOURNAL ARTICLE
Simone Hjæresen, Eirikur Benedikz, Tobias Sejbaek, Markus Axelsson, Lenka Novakova, Mengliang Zhang, Jan Lycke, Zsolt Illes, Åsa Fex-Svenningsen
BACKGROUND: Predictive and prognostic biomarkers for multiple sclerosis (MS) remain a significant gap in MS diagnosis and treatment monitoring. Currently, there are no timely markers to diagnose the transition to secondary progressive MS (SPMS). OBJECTIVE: This study aims to evaluate the discriminatory potential of the High temperature requirement serine protease (HTRA1)/Macrophage migration inhibitory factor (MIF) cerebrospinal fluid (CSF) ratio in distinguishing relapsing-remitting (RRMS) patients from SPMS patients...
February 15, 2024: Journal of the Neurological Sciences
https://read.qxmd.com/read/38261289/-serum-neurofilament-light-chains-in-assessing-the-course-of-multiple-sclerosis
#30
JOURNAL ARTICLE
E M Kamenskikh, V M Alifirova, D V Pashkovskaya, M A Titova, E S Koroleva, L A Levchuk, S A Ivanova
OBJECTIVE: To study a role of serum neurofilament light chains (sNFL) in assessment of course and progression of multiple sclerosis (MS) in the population of patients with MS in the Tomsk region. MATERIAL AND METHODS: The study involved 93 patients with relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS) ( n RRMS =75, n SPMS =18). The study was carried out in a two-stage design: the first stage was a cross-sectional study for the entire sample; the second stage was a prospective observation with two visits for patients with relapse...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38260401/blood-based-targeted-metabolipidomics-reveals-altered-omega-fatty-acid-derived-lipid-mediators-in-relapsing-remitting-multiple-sclerosis-patients
#31
Insha Zahoor, Jeffrey Waters, Nasar Ata, Indrani Datta, Theresa L Pedersen, Mirela Cerghet, Laila Poisson, Silva Markovic-Plese, Ramandeep Rattan, Ameer Y Taha, John W Newman, Shailendra Giri
Unresolved and uncontrolled inflammation is considered a hallmark of pathogenesis in chronic inflammatory diseases like multiple sclerosis (MS), suggesting a defective resolution process. Inflammatory resolution is an active process partially mediated by endogenous metabolites of dietary polyunsaturated fatty acids (PUFA), collectively termed specialized pro-resolving lipid mediators (SPMs). Altered levels of resolution mediators have been reported in several inflammatory diseases and may partly explain impaired inflammatory resolution...
January 6, 2024: bioRxiv
https://read.qxmd.com/read/38255280/immunosuppression-in-sepsis-biomarkers-and-specialized-pro-resolving-mediators
#32
REVIEW
Cristina M Padovani, Kingsley Yin
Severe infection can lead to sepsis. In sepsis, the host mounts an inappropriately large inflammatory response in an attempt to clear the invading pathogen. This sustained high level of inflammation may cause tissue injury and organ failure. Later in sepsis, a paradoxical immunosuppression occurs, where the host is unable to clear the preexisting infection and is susceptible to secondary infections. A major issue with sepsis treatment is that it is difficult for physicians to ascertain which stage of sepsis the patient is in...
January 13, 2024: Biomedicines
https://read.qxmd.com/read/38252817/specialized-proresolving-mediator-resolvin-e1-corrects-the-altered-cystic-fibrosis-nasal-epithelium-cilia-beating-dynamics
#33
JOURNAL ARTICLE
Maëlle Briottet, Khadeeja Sy, Charlie London, Abdel Aissat, Mickael Shum, Virginie Escabasse, Bruno Louis, Valérie Urbach
In cystic fibrosis (CF), impaired mucociliary clearance leads to chronic infection and inflammation. However, cilia beating features in a CF altered environment, consisting of dehydrated airway surface liquid layer and abnormal mucus, have not been fully characterized. Furthermore, acute inflammation is normally followed by an active resolution phase requiring specialized proresolving lipid mediators (SPMs) and allowing return to homeostasis. However, altered SPMs biosynthesis has been reported in CF. Here, we explored cilia beating dynamics in CF airways primary cultures and its response to the SPMs, resolvin E1 (RvE1) and lipoxin B4 (LXB4)...
January 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38244527/the-glymphatic-system-as-a-potential-biomarker-and-therapeutic-target-in-secondary-progressive-multiple-sclerosis
#34
JOURNAL ARTICLE
Yuji Tomizawa, Akifumi Hagiwara, Yasunobu Hoshino, Moto Nakaya, Koji Kamagata, Davide Cossu, Kazumasa Yokoyama, Shigeki Aoki, Nobutaka Hattori
BACKGROUND: Multiple sclerosis (MS) is a refractory immune-mediated inflammatory disease of the central nervous system, and some cases of the major subtype, relapsing-remitting (RR), transition to secondary progressive (SP). However, the detailed pathogenesis, biomarkers, and effective treatment strategies for secondary progressive multiple sclerosis have not been established. The glymphatic system, which is responsible for waste clearance in the brain, is an intriguing avenue for investigation and is primarily studied through diffusion tensor image analysis along the perivascular space (DTI-ALPS)...
March 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38244525/clinical-characterization-of-long-term-multiple-sclerosis-columbus-patients-in-argentina-a-cross-sectional-non-interventional-study
#35
JOURNAL ARTICLE
Norma Deri, Andres Barboza, Carlos Vrech, Roberto Rey, Marcos Burgos, Marcela Fiol, Cristian CalvoVildoso, Liliana Patrucco, Gustavo Jose, Paula Aliberti, Daniela Chirico, Maria B Federico, Gustavo Seifer, Raul Piedrabuena
BACKGROUND: Most Multiple Sclerosis (MS) clinical trials fail to assess the long-term effects of disease-modifying therapies (DMT) or disability. METHODS: COLuMbus was a single-visit, cross-sectional study in Argentina in adult patients with ≥10 years of MS since first diagnosis. The primary endpoint was to determine patient disability using the Expanded Disability Status Scale (EDSS). The secondary endpoints were to evaluate the distribution of diagnoses between relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS), patient demographics, disease history, and the risk of disability progression...
March 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38212940/domain-specific-cognitive-impairment-in-multiple-sclerosis-a-systematic-review-and-meta-analysis
#36
JOURNAL ARTICLE
Katalin Lugosi, Marie A Engh, Zsolt Huszár, Péter Hegyi, Péter Mátrai, Gábor Csukly, Zsolt Molnár, Klaudia Horváth, Dóra Mátis, Zsolt Mezei
OBJECTIVE: Methods of cognitive measurements in multiple sclerosis (MS) are not standardized. We aimed to identify the prevalence of cognitive domain-specific impairment (DSI) in MS by using subtests of the Brief Repeatable Battery of Neuropsychological Tests (BRB-N) with analyzing different cutoff values. METHODS: The systematic review and meta-analysis were registered on PROSPERO (ID: CRD42021287004). The systematic literature search was performed via PubMed, Embase, and CENTRAL on 24 October 2021...
January 11, 2024: Annals of Clinical and Translational Neurology
https://read.qxmd.com/read/38202810/enhancing-flame-retardancy-and-smoke-suppression-in-epoxy-resin-composites-with-sulfur-phosphorous-reactive-flame-retardant
#37
JOURNAL ARTICLE
Xulong Ma, Ni Kang, Yonghang Zhang, Yang Min, Jianhua Yang, Daming Ban, Wei Zhao
The presence of massive amounts of toxic volatiles and smoke during combustion is a very serious problem facing epoxy resin (EP) composites. Therefore, flame retardants (FRs) can simultaneously enhance flame retardancy and reduce the release of smoke and fatal gases. Herein, a novel sulfur-phosphorous reactive flame retardant (SPMS) was synthesized for epoxy resin. The high efficiency of smoke suppression and flame retardancy of the EP/SPMS-APP hybrid was investigated using a cone calorimeter, a vertical burning test, and limited oxygen index measurements...
December 31, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38201304/simulated-microgravity-affects-pro-resolving-properties-of-primary-human-monocytes
#38
JOURNAL ARTICLE
Alessandro Leuti, Marina Fava, Niccolò Pellegrini, Giulia Forte, Federico Fanti, Francesco Della Valle, Noemi De Dominicis, Manuel Sergi, Mauro Maccarrone
Space-related stressors such as microgravity are associated with cellular and molecular alterations of the immune and inflammatory homeostasis that have been linked to the disorders that astronauts suffer from during their missions. Most of the research of the past 30 years has consistently established that innate adaptive immune cells represent a target of microgravity, which leads to their defective or dysfunctional activation, as well as to an altered ability to produce soluble mediators-e.g., cytokines/chemokines and bioactive lipids-that altogether control tissue homeostasis...
January 3, 2024: Cells
https://read.qxmd.com/read/38201221/pro-resolving-mediators-in-rotator-cuff-disease-how-is-the-bursa-involved
#39
JOURNAL ARTICLE
Franka Klatte-Schulz, Nicole Bormann, Aysha Bonell, Jasmin Al-Michref, Hoang Le Nguyen, Pascal Klöckner, Kathi Thiele, Philipp Moroder, Martina Seifert, Birgit Sawitzki, Britt Wildemann, Georg N Duda
So far, tendon regeneration has mainly been analyzed independent from its adjacent tissues. However, the subacromial bursa in particular appears to influence the local inflammatory milieu in the shoulder. The resolution of local inflammation in the shoulder tissues is essential for tendon regeneration, and specialized pro-resolving mediators (SPMs) play a key role in regulating the resolution of inflammation. Here, we aimed to understand the influence of the bursa on disease-associated processes in neighboring tendon healing...
December 20, 2023: Cells
https://read.qxmd.com/read/38199005/impact-of-metastatic-epidural-spinal-cord-compression-mescc-and-pathological-vertebral-compression-fracture-pvcf-in-neurological-and-survival-prognosis
#40
JOURNAL ARTICLE
Aymeric Amelot, Louis-Marie Terrier, Kaissar Farah, Mourad Aggad, Louis-Romée Le Nail, Patrick Francois, Quentin Beaufort, Bertrand Mathon
BACKGROUND: Metastatic epidural spinal cord compression (MESCC) and pathological vertebral compression fractures (pVCF) are the most serious debilitating morbidities of spine metastases (SpMs) causing devastating neurological damages. The respective impact of these two metastasis-spreading entities on survival and on neurological damage is debated. METHODS: A French prospective cohort study collected 279 consecutive patients presenting with SpMs between January 2017 and 2021...
December 28, 2023: European Journal of Surgical Oncology
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