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https://www.readbyqxmd.com/read/27915442/co-exposure-to-low-doses-of-the-food-contaminants-deoxynivalenol-and-nivalenol-has-a-synergistic-inflammatory-effect-on-intestinal-explants
#1
Imourana Alassane-Kpembi, Olivier Puel, Philippe Pinton, Anne-Marie Cossalter, Ting-Chao Chou, Isabelle P Oswald
The global incidence of Fusarium head blight and attendant cereal grains multi-contamination by the trichothecene mycotoxins deoxynivalenol (DON) and nivalenol (NIV) are increasing as a possible result of climate change and inadequate agricultural practices. At the molecular level, these mycotoxins bind to the ribosome, activate the mitogen-activated protein kinase and induce a local and systemic inflammation. DON is of public health concern owing to the narrow margin between exposure and tolerable daily intake...
December 3, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27915289/codon-usage-is-less-optimized-in-eukaryotic-gene-segments-encoding-intrinsically-disordered-regions-than-in-those-encoding-structural-domains
#2
Keiichi Homma, Tamotsu Noguchi, Satoshi Fukuchi
Codon usage tends to be optimized in highly expressed genes. A plausible explanation for this phenomenon is that translational accuracy is increased in highly expressed genes with infrequent use of rare codons. Besides structural domains (SDs), eukaryotic proteins generally have intrinsically disordered regions (IDRs) that by themselves do not assume unique three-dimensional structures. As IDRs are free from structural constraint, they can probably accommodate more translational errors than SDs can. Thus, codon usage in IDRs is likely to be less optimized than that in SDs...
December 1, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27915264/three-dimensional-rotational-angiography-of-the-left-atrium-and-the-oesophagus-the-short-term-mobility-of-the-oesophagus-and-the-stability-of-the-fused-three-dimensional-model-of-the-left-atrium-and-the-oesophagus-during-catheter-ablation-for-atrial-fibrillation
#3
Zdenek Starek, Frantisek Lehar, Jiri Jez, Martin Scurek, Jiri Wolf, Tomas Kulik, Alena Zbankova, Miroslav Novak
AIMS: The objective of this study was to evaluate the mobility of the oesophagus and the stability of the three-dimensional (3D) model of the oesophagus using 3D rotational angiography (3DRA) of the left atrium (LA) and the oesophagus, fused with live fluoroscopy during catheter ablation for atrial fibrillation. METHODS AND RESULTS: From March 2015 to September 2015, 3DRA of the LA and the oesophagus was performed in 33 patients before catheter ablation for atrial fibrillation...
December 2, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27915125/artificial-neural-networks-as-a-powerful-numerical-tool-to-classify-specific-features-of-a-tooth-based-on-3d-scan-data
#4
Stefan Raith, Eric Per Vogel, Naeema Anees, Christine Keul, Jan-Frederik Güth, Daniel Edelhoff, Horst Fischer
Chairside manufacturing based on digital image acquisition is gainingincreasing importance in dentistry. For the standardized application of these methods, it is paramount to have highly automated digital workflows that can process acquired 3D image data of dental surfaces. Artificial Neural Networks (ANNs) arenumerical methods primarily used to mimic the complex networks of neural connections in the natural brain. Our hypothesis is that an ANNcan be developed that is capable of classifying dental cusps with sufficient accuracy...
November 27, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27914911/cervical-cancer-brachytherapy-in-canada-a-focus-on-interstitial-brachytherapy-utilization
#5
Amandeep S Taggar, Tien Phan, Laurel Traptow, Robyn Banerjee, Corinne M Doll
PURPOSE: Brachytherapy (BT) techniques for cervical cancer in Canada have changed over the last decade, with evolution to high-dose-rate and image-guided BT. However, there are currently no national data on the use of interstitial BT (IBT). The purpose of this study was to document IBT utilization in Canadian centers, as well as update details of cervical cancer BT practices. METHODS AND MATERIALS: All Canadian centers with gynecologic BT services (n = 33) were identified, and one gynecology radiation oncologist per center was sent a 33-item e-mail questionnaire regarding their center's practice for cervical cancer BT in 2015...
November 30, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27914847/the-three-dimensional-glenohumeral-subluxation-index-in-primary-osteoarthritis-of-the-shoulder
#6
Matthijs Jacxsens, Alexander Van Tongel, Heath B Henninger, Robert Z Tashjian, Lieven De Wilde
BACKGROUND: Assessment of glenohumeral subluxation is essential in preoperative planning of total shoulder arthroplasty. The purpose of this study was to evaluate a 3-dimensional (3D) glenohumeral subluxation index (GHSI) in shoulders with primary osteoarthritis (OA) and its relationship with morbid glenoid retroversion. METHODS: The 3D computed tomography reconstructions of 120 healthy shoulders and 110 shoulders with primary glenohumeral arthritis (OA group), classified according to Walch's glenoid morphology, were analyzed...
November 30, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27914668/three-dimensional-finite-element-analysis-of-implant-assisted-removable-partial-dentures
#7
Ju-Won Eom, Young-Jun Lim, Myung-Joo Kim, Ho-Beom Kwon
STATEMENT OF PROBLEM: Whether the implant abutment in implant-assisted removable partial dentures (IARPDs) functions as a natural removable partial denture (RPD) tooth abutment is unknown. PURPOSE: The purpose of this 3-dimensional finite element study was to analyze the biomechanical behavior of implant crown, bone, RPD, and IARPD. MATERIAL AND METHODS: Finite element models of the partial maxilla, teeth, and prostheses were generated on the basis of a patient's computed tomographic data...
November 30, 2016: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/27914428/from-local-to-global-measurements-of-nonclassical-nonlinear-elastic-effects-in-geomaterials
#8
Martin Lott, Marcel C Remillieux, Pierre-Yves Le Bas, T J Ulrich, Vincent Garnier, Cédric Payan
In this letter, the equivalence between local and global measures of nonclassical nonlinear elasticity is established in a slender resonant bar. Nonlinear effects are first measured globally using nonlinear resonance ultrasound spectroscopy (NRUS), which monitors the relative shift of the resonance frequency as a function of the maximum dynamic strain in the sample. Subsequently, nonlinear effects are measured locally at various positions along the sample using dynamic acousto elasticity testing (DAET). After correcting analytically the DAET data for three-dimensional strain effects and integrating numerically these corrected data along the length of the sample, the NRUS global measures are retrieved almost exactly...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27914418/direct-noise-simulation-of-a-canonical-high-lift-device-and-comparison-with-an-analytical-model
#9
Pablo Salas, Guillaume Fauquembergue, Stéphane Moreau
The noise of a canonical main-element/flap high-lift device (HLD) is computed directly using compressible wall-resolved Large Eddy Simulation. An experimental database for the chosen configuration allows us to successfully validate the chosen numerical approach. Both the noise sources and the far-field acoustic pressure are shown to be well predicted. Although the two elements trailing-edge noise can be observed in the near field, the flap remains as the dominant source in the far-field. The simplicity of the studied configuration enables the comparison of the validated numerical results with a recently developed analytical model that takes into account the diffraction of the flap noise by the main-element...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27914404/high-frequency-imaging-and-elastic-effects-for-a-solid-cylinder-with-axis-oblique-relative-to-a-nearby-horizontal-surface
#10
Daniel S Plotnick, Philip L Marston
The calibrated acoustic backscattering spectrum versus aspect angle, also called the "acoustic color" or "acoustic template," of solid cylinders located near a flat interface was previously studied for the case where the cylinder axis was vertically oblique relative to the interface and was insonified by a beam at a non-zero grazing angle. The presence of the interface allows for multiple paths by which sound is backscattered. These multipaths are highly dependent on the relative orientations of the target, the interface, and the source/receiver...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27914396/laryngeal-muscular-control-of-vocal-fold-posturing-numerical-modeling-and-experimental-validation
#11
Jun Yin, Zhaoyan Zhang
A three-dimensional continuum model of vocal fold posturing was developed to investigate laryngeal muscular control of vocal fold geometry, stiffness, and tension, which are difficult to measure in live humans or in vivo models. This model was able to qualitatively reproduce in vivo experimental observations of laryngeal control of vocal fold posturing, despite the many simplifications which are necessary due to the lack of accurate data of laryngeal geometry and material properties. The results present a first comprehensive study of the co-variations between glottal width, vocal fold length, stiffness, tension at different conditions of individual, and combined laryngeal muscle activation...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27914395/active-control-of-scattered-acoustic-fields-cancellation-reproduction-and-cloaking
#12
Jordan Cheer
The active control of sound fields has been widely applied in both active noise control and sound field reproduction, however, relatively few studies have focused on active acoustic cloaking. In order to build upon the knowledge and understanding in the areas of active noise control and sound field reproduction, this paper investigates the corresponding physical limitations and compares them to the active cloaking problem when the three strategies are employed in the presence of an acoustic scatterer. The three sound field control strategies have been formulated within a consistent framework, and this has enabled insight into the physical control mechanisms...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27914387/investigation-of-horizontal-refraction-on-florida-straits-continental-shelf-using-a-three-dimensional-gaussian-ray-bundling-model
#13
Sean M Reilly, Gopu R Potty, David Thibaudeau
Acoustic transmission loss measurements from the calibration operations (CALOPS) experiment for the Shallow Water Array Performance (SWAP) program included horizontally refracted returns that were as much as 30° away from the true bearing between source and receiver. In many cases, the in-shore refracted path was 20 dB stronger than the true bearing path. In this study CALOPS transmission loss measurements at 415 Hz are compared to predictions from a three-dimensional Gaussian ray bundling model. The geoacoustic model that provides good model-data comparison is consistent with the geologic and sediment core data collected at the location but differs slightly from the bottom model used at lower frequencies (206 and 52...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27914385/beamforming-pointing-error-of-a-triaxial-velocity-sensor-under-gain-uncertainties
#14
Tsair-Chuan Lin, Kainam Thomas Wong, Macario O Cordel, Joel Paz Ilao
A "triaxial velocity sensor" consists of three uniaxial velocity sensors, which are nominally identical, orthogonally oriented among themselves, and co-centered at one point in space. A triaxial velocity sensor measures the acoustic particle velocity vector, by its three Cartesian components, individually component-by-component, thereby offering azimuth-elevation two-dimensional spatial directivity, despite the physical compactness that comes with the collocation of its three components. This sensing system's azimuth-elevation beam-pattern has been much analyzed in the open literature, but only for an idealized case of the three uniaxial velocity sensors being exactly identical in gain...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27914369/dna-tetrahedral-scaffolds-based-platform-for-the-construction-of-electrochemiluminescence-biosensor
#15
Qiu-Mei Feng, Zhen Zhou, Mei-Xing Li, Wei Zhao, Jing-Juan Xu, Hong-Yuan Chen
Proximal metallic nanoparticles (NPs) could quench the electrochemiluminescence (ECL) emission of semiconductor quantum dots (QDs) due to Förster energy transfer (FRET), but at a certain distance, the coupling of light-emission with surface plasmon resonance (SPR) result in enhanced ECL. Thus, the modification strategies and distances control between QDs and metallic NPs are critical for the ECL intensity of QDs. In this strategy, a SPR enhanced ECL sensor based on DNA tetrahedral scaffolds modified platform was reported for the detection of telomerase activity...
November 27, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27914291/influence-of-laser-power-on-atom-probe-tomographic-analysis-of-boron-distribution-in-silicon
#16
Y Tu, H Takamizawa, B Han, Y Shimizu, K Inoue, T Toyama, F Yano, A Nishida, Y Nagai
The relationship between the laser power and the three-dimensional distribution of boron (B) in silicon (Si) measured by laser-assisted atom probe tomography (APT) is investigated. The ultraviolet laser employed in this study has a fixed wavelength of 355nm. The measured distributions are almost uniform and homogeneous when using low laser power, while clear B accumulation at the low-index pole of single-crystalline Si and segregation along the grain boundaries in polycrystalline Si are observed when using high laser power (100pJ)...
November 25, 2016: Ultramicroscopy
https://www.readbyqxmd.com/read/27914271/individual-exposure-estimates-may-be-erroneous-when-spatiotemporal-variability-of-air-pollution-and-human-mobility-are-ignored
#17
Yoo Min Park, Mei-Po Kwan
This study aims to empirically demonstrate the necessity to consider both the spatiotemporal variability of air pollution and individual daily movement patterns in exposure and health risk assessment. It compares four different types of exposure estimates generated by using (1) individual movement data and hourly air pollution concentrations; (2) individual movement data and daily average air pollution data; (3) residential location and hourly pollution levels; and (4) residential location and daily average pollution data...
November 30, 2016: Health & Place
https://www.readbyqxmd.com/read/27914265/automated-quantification-of-three-dimensional-organization-of-fiber-like-structures-in-biological-tissues
#18
Zhiyi Liu, Dimitra Pouli, Disha Sood, Aswin Sundarakrishnan, Carrie K Hui Mingalone, Lisa M Arendt, Carlo Alonzo, Kyle P Quinn, Charlotte Kuperwasser, Li Zeng, Thomas Schnelldorfer, David L Kaplan, Irene Georgakoudi
Fiber-like structures are prevalent in biological tissues, yet quantitative approaches to assess their three-dimensional (3D) organization are lacking. We develop 3D directional variance, as a quantitative biomarker of truly 3D fibrillar organization by extending the directional statistics formalism developed for describing circular data distributions (i.e. when 0° and 360° are equivalent) to axial ones (i.e. when 0° and 180° are equivalent). Significant advantages of this analysis include its time efficiency, sensitivity and ability to provide quantitative readouts of organization over different size scales of a given data set...
November 25, 2016: Biomaterials
https://www.readbyqxmd.com/read/27914048/geometric-potentials-for-computational-protein-sequence-design
#19
Jie Li, Patrice Koehl
Computational protein sequence design is the rational design based on computer simulation of new protein molecules to fold to target three-dimensional structures, with the ultimate goal of designing novel functions. It requires a good understanding of the thermodynamic equilibrium properties of the protein of interest. Here, we consider the contribution of the solvent to the stability of the protein. We describe implicit solvent models, focusing on approximations of their nonpolar components using geometric potentials...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27913905/proteins-immunologically-related-to-map65-1-accumulate-and-localize-differentially-during-bud-development-in-vitis-vinifera-l
#20
Luigi Parrotta, Claudia Faleri, Mauro Cresti, Giampiero Cai
Various arrays of microtubules are present throughout the plant cell cycle and are involved in distinct functions. Microtubule-associated proteins (MAPs) regulate microtubule dynamics by acting as stabilizers, destabilizers, and promoters of microtubule dynamics. The MAP65 family is a specific group of cross-linkers required for structural maintenance of microtubules. In plants, different isoforms of MAP65 are differentially expressed according to their developmental program. In this work, we analyzed the differential distribution of proteins immunologically related to MAP65-1 during bud development in grapevine (Vitis vinifera L...
December 2, 2016: Protoplasma
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