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https://www.readbyqxmd.com/read/28222509/galantamine-response-associates-with-agitation-and-the-prefrontal-cortex-in-patients-with-alzheimer-s-disease
#1
Sachiko Nakayama, Akimitsu Suda, Hajime Nakanishi, Yumiko Motoi, Nobutaka Hattori
Behavioral and psychological symptoms of dementia (BPSD) occur in up to 80% of AD patients and represent one of the largest factors contributing to caregiver burden. To analyze the effect of galantamine on BPSD and caregiver burden, we treated a total of 50 patients with mild AD for 12 weeks and evaluated them using the Neuropsychiatric Inventory (NPI) and Japanese version of the Zarit Caregiver Burden Interview (ZBI). We also performed regional cerebral blood flow single photon emission computed tomography (rCBF SPECT) at baseline using three-dimensional sterotatic surface projections...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222258/a-simple-and-large-scale-strategy-to-prepare-flexible-graphene-tape-electrode
#2
Li Wang, Jie Yu, Yayun Zhang, Han Yang, Longfei Miao, Yonghai Song
A simple and large-scale strategy to prepare flexible graphene tape electrode (GTE) was proposed. The flexible GTE was prepared by a facile peeling method in which a piece of commercial graphite foil was firstly covered by a commercial acrylic transparent tape and then the transparent adhesive tape was quickly torn off from the graphite foil. Scanning electron microscopy results showed that some folded and wrinkled graphene layers stood up on the GTE surface to form three-dimensional (3D) porous graphene foam...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28222171/metabolite-profiling-of-the-carnivorous-pitcher-plants-darlingtonia-and-sarracenia
#3
Hannu Hotti, Peddinti Gopalacharyulu, Tuulikki Seppänen-Laakso, Heiko Rischer
Sarraceniaceae is a New World carnivorous plant family comprising three genera: Darlingtonia, Heliamphora, and Sarracenia. The plants occur in nutrient-poor environments and have developed insectivorous capability in order to supplement their nutrient uptake. Sarracenia flava contains the alkaloid coniine, otherwise only found in Conium maculatum, in which its biosynthesis has been studied, and several Aloe species. Its ecological role and biosynthetic origin in S. flava is speculative. The aim of the current research was to investigate the occurrence of coniine in Sarracenia and Darlingtonia and to identify common constituents of both genera, unique compounds for individual variants and floral scent chemicals...
2017: PloS One
https://www.readbyqxmd.com/read/28221991/detecting-clinically-meaningful-shape-clusters-in-medical-image-data-metrics-analysis-for-hierarchical-clustering-applied-to-healthy-and-pathological-aortic-arches
#4
Jan L Bruse, Maria A Zuluaga, Abbas Khushnood, Kristin McLeod, Hopewell N Ntsinjana, Tain-Yen Hsia, Maxime Sermesant, Xavier Pennec, Andrew M Taylor, Silvia Schievano
OBJECTIVE: Today's growing medical image databases call for novel processing tools to structure the bulk of data and extract clinically relevant information. Unsupervised hierarchical clustering may reveal clusters within anatomical shape data of patient populations as required for modern Precision Medicine strategies. Few studies have applied hierarchical clustering techniques to three-dimensional patient shape data and results depend heavily on the chosen clustering distance metrics and linkage functions...
February 16, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28221769/manipulation-of-the-precursor-supply-in-yeast-significantly-enhances-the-accumulation-of-prenylated-%C3%AE-carbolines
#5
Katja Backhaus, Lena Ludwig-Radtke, Xiulan Xie, Shu-Ming Li
The tryptophan derivative 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (MTCA) is present in many plants and foods including fermentation products of the baker's yeast Saccharomyces cerevisiae. MTCA is formed from tryp-tophan and acetaldehyde via a Pictet-Spengler reaction. In this study, up to 9 mg/l of MTCA were detected as a mixture of (1S,3S) and (1R,3S) isomers in a ratio of 2.2:1 in Saccharomyces cerevisiae cultures. To the best of our knowledge, this is the first report on the presence of MTCA in laboratory baker's yeast cultures...
February 21, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28221699/beehive-fences-as-a-multidimensional-conflict-mitigation-tool-for-farmers-coexisting-with-elephants
#6
Lucy E King, Fredrick Lala, Hesron Nzumu, Emmanuel Mwambingu, Iain Douglas-Hamilton
Increasing habitat fragmentation and human population growth in Africa has resulted in an escalation in human-elephant conflict between small-scale farmers and free-ranging African elephants (Loxodonta Africana). In 2012 Kenya Wildlife Service (KWS) implemented the national 10-year Conservation and Management Strategy for the Elephant in Kenya, which includes an action aimed at testing whether beehive fences can be used to mitigate human-elephant conflict. From 2012 to 2015, we field-tested the efficacy of beehive fences to protect 10 0...
February 21, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28221044/tunable-volumetric-density-and-porous-structure-of-spherical-poly-%C3%A9-caprolactone-microcarriers-as-applied-in-human-mesenchymal-stem-cell-expansion
#7
Jian Li, Alan Tin-Lun Lam, Jessica Pei Wen Toh, Shaul Reuveny, Steve Kah-Weng Oh, William R Birch
Polymeric microspheres may serve as microcarrier matrices, for the expansion of anchorage-dependent stem cells. They require surface properties that both promote initial cell adhesion and the subsequent spreading of cells, which is a prerequisite for successful expansion. When implemented in a three-dimensional culture environment, under agitation, their suspension under low shear rates depends on the microcarriers having a modest negative buoyancy, with a density of 1.02-1.05 g/cm(3). Bioresorbable polycaprolactone (PCL), with a density of 1...
February 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28221014/value-of-cbct-in-vertical-root-fracture-detection-in-endodontically-treated-teeth
#8
Eshaghali Saberi, Narges F Mollashahi, Zeinab Movasagh, Alireza A Moghaddam, Abbas Mohammadi
BACKGROUND: Vertical root fracture (VRF) is a diagnostic challenge for dentists. Cone-beam computed tomography (CBCT) scans provide accurate three-dimensional images of teeth enabling detection of VRFs. This in-vivo study compared the accuracy of CBCT and exploratory surgery for detection of VRFs in endodontically-treated teeth. METHODS: Forty endodontically-treated teeth of 40 patients with clinical signs and symptoms of VRFs were evaluated. No fracture line was detectable on periapical radiographs...
April 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28220886/earth-s-oldest-bobbit-worm-gigantism-in-a-devonian-eunicidan-polychaete
#9
Mats E Eriksson, Luke A Parry, David M Rudkin
Whilst the fossil record of polychaete worms extends to the early Cambrian, much data on this group derive from microfossils known as scolecodonts. These are sclerotized jaw elements, which generally range from 0.1-2 mm in size, and which, in contrast to the soft-body anatomy, have good preservation potential and a continuous fossil record. Here we describe a new eunicidan polychaete, Websteroprion armstrongi gen. et sp. nov., based primarily on monospecific bedding plane assemblages from the Lower-Middle Devonian Kwataboahegan Formation of Ontario, Canada...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220770/hidden-topological-constellations-and-polyvalent-charges-in-chiral-nematic-droplets
#10
Gregor Posnjak, Simon Čopar, Igor Muševič
Topology has an increasingly important role in the physics of condensed matter, quantum systems, material science, photonics and biology, with spectacular realizations of topological concepts in liquid crystals. Here we report on long-lived hidden topological states in thermally quenched, chiral nematic droplets, formed from string-like, triangular and polyhedral constellations of monovalent and polyvalent singular point defects. These topological defects are regularly packed into a spherical liquid volume and stabilized by the elastic energy barrier due to the helical structure and confinement of the liquid crystal in the micro-sphere...
February 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28220758/a-bio-inspired-electrocommunication-system-for-small-underwater-robots
#11
Wei Wang, Jindong Liu, Guangming Xie, Li Wen, Jianwei Zhang
Weakly electric fishes (Gymnotid and Mormyrid) use an electric field to communicate efficiently (termed electrocommunication) in the turbid waters of confined spaces where other communication modalities fail. Inspired by this biological phenomenon, we design an artificial electrocommunication system for small underwater robots and explore the capabilities of such an underwater robotic communication system. An analytical model for electrocommunication is derived to predict the effect of the key parameters such as electrode distance and emitter current of the system on the communication performance...
February 21, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28220752/putting-3d-modelling-and-3d-printing-into-practice-virtual-surgery-and-preoperative-planning-to-reconstruct-complex-post-traumatic-skeletal-deformities-and-defects
#12
Kevin Tetsworth, Steve Block, Vaida Glatt
3D printing technology has revolutionized and gradually transformed manufacturing across a broad spectrum of industries, including healthcare. Nowhere is this more apparent than in orthopaedics with many surgeons already incorporating aspects of 3D modelling and virtual procedures into their routine clinical practice. As a more extreme application, patient-specific 3D printed titanium truss cages represent a novel approach for managing the challenge of segmental bone defects. This review illustrates the potential indications of this innovative technique using 3D printed titanium truss cages in conjunction with the Masquelet technique...
2017: SICOT-J
https://www.readbyqxmd.com/read/28220659/in-situ-self-assembled-reduced-graphene-oxide-aerogel-embedded-with-nickel-oxide-nanoparticles-for-the-high-efficiency-separation-of-ovalbumin
#13
Lei Chen, Dong-Hua Zheng, Ying Zhang, Ya-Ning Wang, Zhang-Run Xu
A three-dimensional reduced graphene oxide aerogel with embedded nickel oxide nanoparticles was prepared by a one-step self-assembly reaction in a short time. The nanoparticles could be captured into the interior of reduced graphene oxide network during the formation of the three-dimensional architecture. The composite exhibited porosity, good biocompatibility and abundant metal affinity binding sites. The aerogel was used to isolate ovalbumin selectively from egg white, and favorable adsorption was achieved at pH 3...
February 21, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28220629/binding-of-hydroxylated-polybrominated-diphenyl-ethers-with-human-serum-albumin-spectroscopic-characterization-and-molecular-modeling
#14
Lulu Yang, Wu Yang, Zhiwei Wu, Zhongsheng Yi
Three hydroxylated polybrominated diphenyl ethers (OH-PBDEs), 3-OH-BDE-47, 5-OH-BDE-47, and 6-OH-BDE-47, were selected to investigate the interactions between OH-PBDEs with human serum albumin (HSA) under physiological conditions. The observed fluorescence quenching can be attributed to the formation of complexes between HSA and OH-PBDEs. The thermodynamic parameters at different temperatures indicate that the binding was caused by hydrophobic forces and hydrogen bonds. Molecular modeling and three-dimensional fluorescence spectrum showed conformational and microenvironmental changes in HSA...
February 21, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28220610/comparison-and-analysis-on-the-serum-binding-characteristics-of-aspirin-zinc-complex-and-aspirin
#15
Hua-Xin Zhang, Qun Zhang, Hong-Lin Wang, Li-Wei Li
This study was designed to compare the protein-binding characteristics of aspirin-zinc complex (AZN) with those of aspirin itself. AZN was synthesized and interacted with a model transport protein, human serum albumin (HSA). Three-dimensional fluorescence, ultraviolet-visible and circular dichroism (CD) spectra were used to characterize the interaction of AZN with HSA under physiological conditions. The interaction mechanism was explored using a fluorescence quenching method and thermodynamic calculation. The binding site and binding locality of AZN on HSA were demonstrated using a fluorescence probe technique and Förster non-radiation energy transfer theory...
February 21, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28220548/relationship-of-physical-activity-with-physical-function-and-health-related-quality-of-life-in-patients-having-undergone-allogeneic-haematopoietic-stem-cell-transplantation
#16
S Morishita, K Kaida, S Yamauchi, T Wakasugi, K Ikegame, H Ogawa, K Domen
In this study, we investigated the differences in physical activity before and after transplantation, and the relationship between physical activity and physical function and health-related quality of life (QOL) in 30 patients who underwent allogeneic haematopoietic stem cell transplantation (allo-HSCT). Duration and intensity of physical activity were quantified using a three-dimensional accelerometer. Physical function was quantified by handgrip and knee-extensor strength, with the 6-minute walk test (6MWT) used as a measure of exercise capacity...
February 21, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28220492/magnetic-resonance-imaging-of-intratympanic-gadolinium-helps-differentiate-vestibular-migraine-from-m%C3%A3-ni%C3%A3-re-disease
#17
Wenfang Sun, Ping Guo, Tongli Ren, Wuqing Wang
OBJECTIVES/HYPOTHESIS: To study the differential diagnosis of vestibular migraine (VM) and Ménière disease (MD) by using magnetic resonance imaging (MRI) of intratympanic gadolinium. STUDY DESIGN: Prospective cohort study. METHODS: Definite MD patients (n = 30) and definite or probable VM patients (n = 30) were included, and the two groups were age and sex matched. Three-dimensional real inversion recovery (3D-real-IR) MRI was performed 24 hours after bilateral intratympanic gadolinium to assess the presence and degree of endolymphatic hydrops (EH)...
February 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28220396/evaluation-of-the-turning-characteristics-according-to-the-severity-of-parkinson-disease-during-the-timed-up-and-go-test
#18
Minji Son, Changhong Youm, Sangmyung Cheon, Jaewoo Kim, Meounggon Lee, Youkyung Kim, Jinhee Kim, Hyeryun Sung
BACKGROUND: Patients with Parkinson disease (PD) experience problems such as falls and freezing of gait during walking and turning in daily activities. However, few studies have examined the relationship between simultaneous turning tasks and the severity of PD. AIM: To investigate turning characteristics in patients with PD using three-dimensional (3D) analysis during the timed up and go (TUG) test. METHODS: Thirty individuals performed the TUG test under 3D motion analysis: 10 patients with Hoehn and Yahr (H&Y) stages 2...
February 20, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28220303/estimation-of-stature-from-femur-length-measured-using-computed-tomography-after-the-analysis-of-three-dimensional-characteristics-of-femur-bone-in-korean-cadavers
#19
Sookyoung Lee, Ho-Hyeon Gong, Jin-Young Hyun, Hyung-Nam Koo, Han-Young Lee, Nak-Eun Chung, Young-Shik Choi, Kyung-Moo Yang, Byung Ha Choi
Estimation of stature is a basic and important forensic procedure in identifying decomposed or skeletonized bodies. Due to advances in radiologic equipment, forensic science frequently uses computed tomography (CT) and software to apply these findings to investigations. Technical developments have increased the accuracy of the measurement of various bones. However, there are still some inaccuracies, such as defining correct landmarks in three-dimensional (3D) images. Femur length is frequently used for calculation of stature, but because it is a 3D structure, the digital image may not always correlate with the femur length measured with an osteometric board...
February 20, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28220146/horseback-riding-improves-the-ability-to-cause-the-appropriate-action-go-reaction-and-the-appropriate-self-control-no-go-reaction-in-children
#20
Nobuyo Ohtani, Kenji Kitagawa, Kinuyo Mikami, Kasumi Kitawaki, Junko Akiyama, Maho Fuchikami, Hidehiko Uchiyama, Mitsuaki Ohta
BACKGROUND: There are many obvious health benefits to riding, including developing a strong core and legs, but there are also many less obvious benefits, such as increased confidence and introspection. Few studies have addressed the effects of horseback riding on children and the mechanisms underlying how riding affects humans. We examined the effects of horseback riding on the ability to distinguish Go/No-go tasks and solve arithmetic problems in children. METHODS: The subjects were 34 boys and 72 girls, aged 10-12 years old, which were divided into three groups (horse riding, walking, and resting)...
2017: Frontiers in Public Health
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