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https://www.readbyqxmd.com/read/28922738/mixed-symptoms-in-major-depressive-and-bipolar-disorders-a-systematic-review
#1
REVIEW
Gustavo H Vázquez, María Lolich, Casimiro Cabrera, Ruzica Jokic, Dusan Kolar, Leonardo Tondo, Ross J Baldessarini
BACKGROUND: The DSM-5 mixed features specifier for mood disorders encourages renewed interest in mixed states and led us to pool research findings regarding prevalence of mixed features in episodes of major depressive (MDD) and bipolar disorders (BD). METHODS: We systematically searched to July 2017 for reports on mixed symptoms in depressive episodes of MDD and in depression and mania or hypomania in types I and II BD. For primary mood-states and diagnostic groups we compared rates of the presence of mixed symptoms: as defined by DSM-5 (≥3 features opposite to the dominant mood-polarity but not overlapping those of the primary disorder) or as having any ≥3 features of opposite polarity...
September 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28922729/lithium-induced-oxidative-damage-and-inflammation-in-the-rat-s-heart-protective-effect-of-grape-seed-and-skin-extract
#2
Ali Mezni, Hanène Aoua, Olfa Khazri, Ferid Limam, Ezzeddine Aouani
Lithium (Li) is a relevant mood stabilizer metal for the treatment of bipolar disorder (BD), as it protects from both depression and mania and reduces the risk of suicide. However, Lihas some clinical concerns as a narrow therapeutic index requiring routine monitoring of the serum level. The present study was designed to analyze the cardio-toxic side effect of Li and the ability of grape seed and skin extract (GSSE) to protect the heart against such toxicity. After 30days of exposure to Li (0, 2, 5 and 100mg/kg bw) and prevention with GSSE (4000mg/kg bw), rats were killed by decapitation and their heart processed for Li-induced oxidative stress...
September 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28922592/determining-if-borderline-personality-disorder-and-bipolar-disorder-are-alternative-expressions-of-the-same-disorder-results-from-the-national-epidemiologic-survey-on-alcohol-and-related-conditions
#3
Iris de la Rosa, María A Oquendo, Gemma García, Barbara Stanley, Ana González-Pinto, Shang-Min Liu, Carlos Blanco
OBJECTIVE: To examine whether bipolar disorder and borderline personality disorder represent 2 different disorders or alternative manifestations of the same disorder. METHODS: The data were collected between January 1, 2004, and December 31, 2005. The analyses were conducted between December 21 and December 27, 2010. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were performed on 25 symptoms assessing depression, mania, and borderline personality disorder from the National Epidemiologic Survey on Alcohol and Related Conditions, a large nationally representative sample of the US adult population (N = 34,653)...
September 5, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28922589/higher-baseline-proinflammatory-cytokines-mark-poor-antidepressant-response-in-bipolar-disorder
#4
Francesco Benedetti, Sara Poletti, Thomas A Hoogenboezem, Clara Locatelli, Harm de Wit, Annemarie J M Wijkhuijs, Cristina Colombo, Hemmo A Drexhage
BACKGROUND: The clinical relevance of raised levels of circulating cytokines in bipolar disorder is still unclear. Cytokines influence neurotransmitters, neuroplasticity, and white matter integrity. An inconsistent literature suggests that higher cytokine levels could hamper antidepressant response. Total sleep deprivation (TSD) and light therapy (LT) prompt a rapid antidepressant response and can provide a model treatment to study predictors of response. METHODS: We studied at baseline 15 immune-regulating compounds in 37 consecutively admitted inpatients with a major depressive episode in the course of bipolar disorder (DSM-5 criteria) and in 24 controls...
September 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28921840/the-role-of-cadherin-genes-in-five-major-psychiatric-disorders-a-literature-update
#5
REVIEW
Ziarih Hawi, Janette Tong, Callum Dark, Hannah Yates, Beth Johnson, Mark A Bellgrove
Converging evidence from candidate gene, genome-wide linkage, and association studies support a role of cadherins in the pathophysiology of five major psychiatric disorders including attention deficit hyperactivity disorder, autism spectrum disorder (ASD), schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). These molecules are transmembrane proteins which act as cell adhesives by forming adherens junctions (AJs) to bind cells within tissues. Members of the cadherin superfamily are also involved in biological processes such as signal transduction and plasticity that have been implicated in the etiology of major psychiatric conditions...
September 18, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28921675/altered-cav1-2-function-in-the-timothy-syndrome-mouse-model-produces-ascending-serotonergic-abnormalities
#6
Daniel G Ehlinger, Kathryn G Commons
Polymorphism in the gene CACNA1C, encoding the pore-forming subunit of Cav1.2 L-type calcium channels, has one of the strongest genetic linkages to schizophrenia, bipolar disorder, and major depressive disorder: psychopathologies in which serotonin signaling has been implicated. Additionally, a gain-of-function mutation in CACNA1C is responsible for the neurodevelopmental disorder Timothy Syndrome that presents with prominent behavioral features on the autism spectrum. Given an emerging role for serotonin in the etiology of autism spectrum disorders, we investigate the relationship between Cav1...
September 16, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28918859/a-preliminary-study-of-bipolar-disorder-type-i-by-mass-spectrometry-based-serum-lipidomics
#7
Henrique C Ribeiro, Aline Klassen, Mariana Pedrini, Michelle S Carvalho, Lucas B Rizzo, Mariane N Noto, Maiara Zeni-Graiff, Sumit Sethi, Francisco A H Fonseca, Ljubica Tasic, Mirian A F Hayashi, Quirino Cordeiro, Elisa Brietzke, Alessandra Sussulini
The present study aimed at investigating possible alterations in the serum lipid profile of euthymic patients with bipolar disorder type I (BD) compared to healthy controls (HC). Thirty-five individuals from both genders were recruited, with 14 diagnosed and treated as BD patients (BD group) and 21 healthy subjects (HC group). Clinical assessment was based on the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Young Mania Rating Scale (YMRS), and 17-items of Hamilton Depression Rating Scale (HDRS-17) data, which were used to confirm diagnosis, to verify psychiatric comorbidities, and to estimate the severity of manic and depressive symptoms...
August 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28918761/quality-of-life-in-bipolar-disorder-towards-a-dynamic-understanding
#8
E Morton, G Murray, E E Michalak, R W Lam, S Beaulieu, V Sharma, P Cervantes, S V Parikh, L N Yatham
BACKGROUND: Although quality of life (QoL) is receiving increasing attention in bipolar disorder (BD) research and practice, little is known about its naturalistic trajectory. The dual aims of this study were to prospectively investigate: (a) the trajectory of QoL under guideline-driven treatment and (b) the dynamic relationship between mood symptoms and QoL. METHODS: In total, 362 patients with BD receiving guideline-driven treatment were prospectively followed at 3-month intervals for up to 5 years...
September 18, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28918419/-about-the-association-between-antipsychotic-medication-and-cardiovascular-morbidity-epidemiology-and-possible-background-mechanisms
#9
Gabor Gaszner, Gabor Barna, Peter Dome
The history of antipsychotics began with the discovery of chlorpromazine in the 1950s. Since then this group of medications has become one of the most important element of the armamentarium of psychopharmacology. While initially these pharmacons were used in the treatment of psychotic states (including psychotic mania) in the last approximately 10-15 years new indications - such as treatment of depressive, manic and mixed states and also mood-stabilization in bipolar disorder and also the treatment of major depressive disorder - for several second-generation antipsychotic (SGA) agents have been introduced...
June 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/28918417/-clinical-features-of-psychotic-and-non-psychotic-bipolar-patients
#10
Zsuzsanna Belteczki, Zoltan Rihmer, Julia Ujvari
BACKGROUND: Psychotic symptoms are common in the case of manic, depressive and mixed episodes of bipolar disorder; however, the assessment of delusions and hallucinations is frequently improper, thus the patients presenting also psychotic symptoms are treated based on their diagnosis of schizophrenia, schizoaffective disorder or paranoia. Psychotic symptoms in bipolar disorder result less favourable outcomes and course of illness. METHODS: 365 patients (106 males, 259 females) were hospitalized in or institution from January 1st 2015 to September 30th 2016, who were diagnosed with bipolar disorder according to the ICD-10 criteria...
June 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/28918241/stigma-experienced-by-patients-with-severe-mental-disorders-a-nationwide-multicentric-study-from-india
#11
Sandeep Grover, Ajit Avasthi, Aakanksha Singh, Amitava Dan, Rajarshi Neogi, Darpan Kaur, Bhavesh Lakdawala, Abhijit R Rozatkar, Naresh Nebhinani, Suravi Patra, Priya Sivashankar, Alka A Subramanyam, Adarsh Tripathi, Ab Majid Gania, Gurvinder Pal Singh, Prakash Behere
This study aimed to evaluate the stigma and its correlates among patients with severe mental disorders. Patients with diagnosis of schizophrenia (N = 707), bipolar disorder (N = 344) and recurrent depressive disorder (N = 352) currently in clinical remission from 14 participating centres were assessed on Internalized Stigma of Mental Illness Scale (ISMIS). Patients with diagnosis of schizophrenia experienced higher level of alienation, sterotype endorsement, discrimination experience and total stigma when compared to patients with bipolar disorder and recurrent depressive disorder...
August 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28917190/posttraumatic-stress-symptoms-and-dissociation-between-childhood-trauma-and-two-different-types-of-psychosis-like-experience
#12
Ji Young Choi
This study examined the roles of posttraumatic stress (PTS) symptoms and dissociation in the relationship between childhood trauma and two different types of psychosis-like experience, including persecutory ideation and aberrant experience, in non-psychotic psychiatric patients. From August 2015 to August 2016, among psychiatric out patients seeking treatment at the Department of Psychiatry at a major teaching medical hospital in Seoul, Korea, 169 patients who had never been diagnosed with a psychotic disorder, including schizophrenia spectrum disorder, bipolar disorder, and/or depressive disorder with psychotic features, completed the Korean Childhood Trauma Questionnaire, the Korean version of the Impact of Event Scale-Revised, the modified Korean version of the Peritraumatic Dissociation Experiences Questionnaire, and the Korean Minnesota Multiphasic Personality Inventory-2 (MMPI-2)...
September 13, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28914726/pro-inflammatory-cytokines-mood-and-sleep-in-interepisode-bipolar-disorder-and-insomnia-a-pilot-study-with-implications-for-psychosocial-interventions
#13
Michael R Dolsen, Adriane M Soehner, Allison G Harvey
OBJECTIVE: Pro-inflammatory cytokines are associated with bipolar disorder (BD), but less is known about how cytokines function during the interepisode period. This study examined cytokines, mood symptoms, and sleep in individuals with interepisode BD with complaints of insomnia. We also investigated the effects of a BD-specific modification of cognitive behavior therapy for insomnia (CBTI-BP) on cytokine levels. METHODS: The 22 adults with interepisode BD Type I and insomnia were drawn from a subset of an NIMH-funded study...
September 13, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28912043/abnormal-segments-of-right-uncinate-fasciculus-and-left-anterior-thalamic-radiation-in-major-and-bipolar-depression
#14
Feng Deng, Ying Wang, Huiyuan Huang, Meiqi Niu, Shuming Zhong, Ling Zhao, Zhangzhang Qi, Xiaoyan Wu, Yao Sun, Chen Niu, Yuan He, Li Huang, Ruiwang Huang
Differential brain structural abnormalities between bipolar disorder (BD) and major depressive disorder (MDD) may reflect different pathological mechanisms underlying these two brain disorders. However, few studies have directly compared the brain structural properties, especially in white matter (WM) tracts, between BD and MDD. Using automated fiber-tract quantification (AFQ), we utilized diffusion tensor images (DTI) from 67 unmedicated depressed patients, including 31 BD and 36 MDD, and 45 healthy controls (HC) to create fractional anisotropy (FA) tract profiles along 20 major WM tracts...
September 11, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28912037/the-role-of-mental-imagery-in-mood-amplification-an-investigation-across-subclinical-features-of-bipolar-disorders
#15
Caitlin O'Donnell, Martina Di Simplicio, Randi Brown, Emily A Holmes, Stephanie Burnett Heyes
Vivid emotional mental imagery has been identified across a range of mental disorders. In bipolar spectrum disorders - psychopathologies characterized by mood swings that alternate between depression and mania, and include irritability and mixed affect states - mental imagery has been proposed to drive instability in both 'positive' and 'negative' mood. That is, mental imagery can act as an "emotional amplifier". The current experimental study tested this hypothesis and investigated imagery characteristics associated with mood amplification using a spectrum approach to psychopathology...
August 18, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28911851/cortisol-awakening-response-in-patients-with-bipolar-disorder-during-acute-episodes-and-partial-remission-a-pilot-study
#16
Ming-Chyi Huang, Shan-Chi Chuang, Mei-Chih Meg Tseng, Yi-Ling Chien, Shih-Cheng Liao, Hsi-Chung Chen, Po-Hsiu Kuo
This exploratory study examined the cortisol awakening response (CAR) in patients with bipolar disorder (BPD) at acute phases and partial remission of manic or depressive episodes. Saliva samples of twenty-seven BPD inpatients and 25 healthy controls were collected to determine the CAR patterns, and 12 patients were sampled again at partial remission. BPD patients exhibited a non-enhanced CAR pattern. Lower cortisol expression and a blunted CAR distinguished bipolar-depressive patients from the controls. The intra-individual follow-up for both patient groups revealed a non-significant improvement in CAR patterns, indicating a trend of a normalized CAR after partial remission for BPD patients...
September 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28910601/identification-of-plasma-biomarkers-for-distinguishing-bipolar-depression-from-major-depressive-disorder-by-itraq-coupled-lc-ms-ms-and-bioinformatics-analysis
#17
Juanjuan Ren, Guoqing Zhao, Xiujia Sun, Hongmei Liu, Ping Jiang, Jun Chen, Zhiguo Wu, Daihui Peng, Yiru Fang, Chen Zhang
It is important to differentiate between bipolar disorder (BD) and major depressive disorder (MDD) in the first depressive episode because of the potential treatment implications. Previous studies have mainly focused on the different clinical features or pathological biomarkers to distinguish these two diseases; however, a better understanding of the proteomics profiling of BD may help aid future therapeutic strategies. Here, we applied isobaric tags for relative and absolute quantification (iTRAQ) technology combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify differentially expressed proteins between MDD and bipolar depression (BP)...
September 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28906604/a-multisymptomatic-child-with-bipolar-disorder-how-to-track-and-sequence-treatment
#18
Robert M Post, Michael Rowe, Dana Kaplan, Robert L Findling
Treatment sequences for the multisymptomatic child with bipolar disorder are not adequately described or based on a systematic clinical trial database, and systems for longitudinal tracking of symptoms are rarely utilized. We present a patient whose symptoms of depression, anxiety, attention-deficit/hyperactivity disorder, oppositional behavior, and mania are rated by a parent and plotted on a weekly basis in the Child Network under a Johns Hopkins Institutional Review Board-approved protocol. This 9-year-old girl remained inadequately responsive to lithium or risperidone...
August 31, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28906054/neuropathological-comorbidity-associated-with-argyrophilic-grain-disease
#19
REVIEW
Osamu Yokota, Tomoko Miki, Chikako Ikeda, Shigeto Nagao, Shintaro Takenoshita, Hideki Ishizu, Takashi Haraguchi, Shigetoshi Kuroda, Seishi Terada, Norihito Yamada
Argyrophilic grain disease (AGD) is a common four-repeat tauopathy in elderly people. While dementia is a major clinical picture of AGD, recent studies support the possibility that AGD may be a pathological base in some patients with mild cognitive impairment, late-onset psychosis, bipolar disorder and depression. AGD often coexists with various other degenerative changes. The frequency of AGD in progressive supranuclear palsy (PSP) cases was reported to range from 18.8% to 80%. The frequency of AGD in corticobasal degeneration (CBD) cases tends to be higher than that in PSP cases, ranging from 41...
September 14, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28904813/seasonal-affective-disorder-and-non-seasonal-affective-disorders-results-from-the-nesda-study
#20
Wim H Winthorst, Annelieke M Roest, Elisabeth H Bos, Ybe Meesters, Brenda W J H Penninx, Willem A Nolen, Peter de Jonge
BACKGROUND: Seasonal affective disorder (SAD) is considered to be a subtype of depression. AIMS: To compare the clinical picture of SAD to non-seasonal affective disorders (non-SADs). METHOD: Diagnoses according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) were established in 2185 participants of the Netherlands Study of Depression and Anxiety. The Seasonal Pattern Assessment Questionnaire was administered to diagnose SAD...
July 2017: BJPsych Open
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