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https://www.readbyqxmd.com/read/28537447/hypocretin-measurement-shelf-age-of-radioimmunoassay-kit-but-not-freezer-time-influences-assay-variability
#1
Glenda Keating, Donald L Bliwise, Prabhjyot Saini, David B Rye, Lynn Marie Trotti
The hypothalamic peptide hypocretin 1 (orexin A) may be assayed in cerebrospinal fluid to diagnose narcolepsy type 1. This testing is not commercially available, and factors contributing to assay variability have not previously been comprehensively explored. In the present study, cerebrospinal fluid hypocretin concentrations were determined in duplicate in 155 patient samples, across a range of sleep disorders. Intra-assay variability of these measures was analyzed. Inter-assay correlation between samples tested at Emory and at Stanford was high (r = 0...
May 24, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28536486/emerging-indications-for-fractionated-gamma-knife-radiosurgery
#2
Emory McTyre, Corbin A Helis, Michael Farris, Lisa Wilkins, Darrell Sloan, William H Hinson, J Daniel Bourland, William A Dezarn, Michael T Munley, Kounosuke Watabe, Fei Xing, Adrian W Laxton, Stephen B Tatter, Michael D Chan
BACKGROUND: Gamma Knife radiosurgery (GKRS) allows for the treatment of intracranial tumors with a high degree of dose conformality and precision. There are, however, certain situations wherein the dose conformality of GKRS is desired, but single session treatment is contraindicated. In these situations, a traditional pin-based GKRS head frame cannot be used, as it precludes fractionated treatment. OBJECTIVE: To report our experience in treating patients with fractionated GKRS using a relocatable, noninvasive immobilization system...
February 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28532575/readmission-rates-after-transcatheter-aortic-valve-replacement-in-high-and-extreme-risk-patients-with-severe-aortic-stenosis
#3
Jessica Forcillo, Jose F Condado, Jose N Binongo, Yi Lasanajak, Hope Caughron, Vasilis Babaliaros, Chandan Devireddy, Bradley Leshnower, Robert A Guyton, Peter C Block, Amy Simone, Patricia Keegan, Paul Khairy, Vinod H Thourani
OBJECTIVE: In high- or extreme-risk patients undergoing transcatheter aortic valve replacement, readmissions have not been adequately studied and are the subject of increased scrutiny by healthcare systems. The objectives of this study were to determine the incidence of 30-day and 1-year cardiac and noncardiac readmissions, identify predictors of readmission, and assess the association between readmission and 1-year mortality. METHODS: A retrospective review was performed on 714 patients who underwent transcatheter aortic valve replacement from September 2007 to January 2015 at Emory University...
April 18, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28511975/leptomeningeal-failure-in-patients-with-breast-cancer-receiving-stereotactic-radiosurgery-for-brain-metastases
#4
REVIEW
Edina C Wang, Andrew J Huang, Karen E Huang, Emory R McTyre, Hui-Wen Lo, Kounosuke Watabe, Linda Metheny-Barlow, Adrian W Laxton, Stephen B Tatter, Roy E Strowd, Michael D Chan, Brandi R Page
PURPOSE: Prior studies suggest a high incidence of leptomeningeal failure (LMF) in breast cancer metastatic to brain. This study examines breast cancer-specific variables affecting development of LMF and survival after Gamma-Knife Radiosurgery (GKS). METHODS: Between 2000-2010, 149 (breast) and 658 other-histology patients were treated with GKS. Hormone/HER2, age, local/distant brain failure, prior craniotomy, and prior whole-brain radiotherapy (WBRT) were assessed...
May 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28481592/luciano-l-abate-1928-2016
#5
Robert Henley Woody
This article memorializes Luciano L'Abate (1928 -2016). In 1964, L'Abate became an assistant professor of medical psychology at the Washington University School of Medicine and, in 1965, an associate professor of pediatrics in the Emory University School of Medicine. He then transitioned to the Georgia State University (GSU), where he was promoted to professor of psychology. From 1965 to 1990, he served as director of the Family Psychology Program and Family Study Center at GSU. In retirement, L'Abate increased his writing and lecturing...
May 2017: American Psychologist
https://www.readbyqxmd.com/read/28474107/-foot-drop-treatment-by-implantation-of-a%C3%A2-neuroprosthesis-actigait%C3%A2
#6
D Yao, E Jakubowitz, S Ettinger, C Plaass, C Stukenborg-Colsman, K Daniilidis
OBJECTIVE: Gait improvement by restoring dorsiflexion using a neuroprosthesis implant. INDICATIONS: Foot drop with damage to the 1st motor neuron; passive mobility in ankle is possible; adult patients. CONTRAINDICATIONS: Foot drop with peripheral damage and injury to the peroneal nerve; already implanted stimulators (e.g., defibrillator, pacemaker, or pain stimulator); severe anesthesia risks in multimorbid patients. SURGICAL TECHNIQUE: Surgery in lateral position...
May 4, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28472248/accounting-for-tumor-purity-improves-cancer-subtype-classification-from-dna-methylation-data
#7
Weiwei Zhang, Hao Feng, Hao Wu, Xiaoqi Zheng
Motivation: Tumor sample classification has long been an important task in cancer research. Classifying tumors into different subtypes greatly benefits therapeutic development and facilitates application of precision medicine on patients. In practice, solid tumor tissue samples obtained from clinical settings are always mixtures of cancer and normal cells. Thus, the data obtained from these samples are mixed signals. The "tumor purity", or the percentage of cancer cells in cancer tissue sample, will bias the clustering results if not properly accounted for...
May 4, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28459761/a-novel-weaning-protocol-for-high-flow-nasal-cannula-in-the-picu
#8
Kristina A Betters, Kiran B Hebbar, Courtney McCracken, David Heitz, Stephanie Sparacino, Toni Petrillo
OBJECTIVE: High-flow nasal cannula use in the PICU continues to increase; however, a protocol for weaning patients has yet to be published. This study aimed to create an efficient and safe protocol for weaning high-flow nasal cannula. DESIGN: A Respiratory Assessment Score was created using two validated scoring systems. A protocol was established for set "holidays" off high-flow nasal cannula, where nasal cannula flow was reduced to age-based low-flow nasal cannula rates if Respiratory Assessment Scores met certain criteria...
April 27, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28426239/performance-of-an-artificial-pancreas-system-for-young-children-with-type-1-diabetes
#9
Mark D DeBoer, Marc D Breton, Christian Wakeman, Elaine M Schertz, Emma G Emory, Jessica L Robic, Laura L Kollar, Boris P Kovatchev, Daniel R Cherñavvsky
BACKGROUND: Young children 5-8 years old with type 1 diabetes (T1D) exhibit clear needs for improved glycemic control but may be limited in their ability to safely interact with an artificial pancreas system. Our goal was to evaluate the safety and performance of an artificial pancreas (AP) system among young children with T1D. RESEARCH DESIGN AND METHODS: In a randomized, crossover trial, children with T1D age 5-8 years were enrolled to receive on separate study periods (in random order) either the UVa AP using the DiAs Control Platform software with child-resistant lock-out screens (followed as an out-patient admission) or their usual insulin pump+continuous glucose monitor (CGM) care at home...
May 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28424653/disentangling-stigma-from-functional-neurological-disorders-conference-report-and-roadmap-for-the-future
#10
Karen S Rommelfanger, Stewart A Factor, Suzette LaRoche, Phyllis Rosen, Raymond Young, Mark H Rapaport
A multidisciplinary expert review of key issues and future directions from the conference "Controversial labels and clinical uncertainties: psychogenic disorders, conversion disorder, and functional symptoms." On October 9 and 10, 2015, a conference entitled "Controversial labels and clinical uncertainties: psychogenic disorders, conversion disorder, and functional symptoms" was held at the Center for Ethics, Emory University, Atlanta, GA, USA. This conference brought together a select group of 30 distinguished thought leaders and practitioners, including ethicists, researchers, clinicians, humanities scholars, and advocates to discuss the unique challenges and controversies related to the diagnosis, treatment, and stigma for patients with what is currently recognized as functional ("psychogenic") neurological disorders...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28421176/distributed-learning-revitalizing-anesthesiology-training-in-resource-limited-ethiopia
#11
Krupa B Patel, Morgan Dooley, Ananya Abate, Vanessa Moll
BACKGROUND: Ethiopia has a significant paucity of available health-care workers. Despite the increasing number of medical schools, there are not enough physician instructors. Furthermore, availability and standardization of postgraduate training are lacking. Modalities of e-learning have been shown to be successful when used to impart medical education in other resource-limited countries. The Emory University and Addis Ababa University (AAU) Departments of Anesthesiology have formed a collaboration with the intent of improving the AAU Anesthesiology residency program, one of two postgraduate training programs for anesthesiology in Ethiopia...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28407643/the-use-of-mathematical-models-of-chlamydia-transmission-to-address-public-health-policy-questions-a-systematic-review
#12
Minttu M Rönn, Emory E Wolf, Harrell Chesson, Nicolas A Menzies, Kara Galer, Rachel Gorwitz, Thomas Gift, Katherine Hsu, Joshua A Salomon
BACKGROUND: Mathematical models of chlamydia transmission can help inform disease control policy decisions when direct empirical evaluation of alternatives is impractical. We reviewed published chlamydia models to understand the range of approaches used for policy analyses and how the studies have responded to developments in the field. METHODS: We performed a literature review by searching Medline and Google Scholar (up to October 2015) to identify publications describing dynamic chlamydia transmission models used to address public health policy questions...
May 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28407623/fine-needle-aspiration-of-langerhans-cell-histiocytosis-a-cytopathologic-study-of-37-cases
#13
Jen-Fan Hang, Momin T Siddiqui, Syed Z Ali
OBJECTIVE: Langerhans cell histiocytosis (LCH) is an uncommon neoplasm of dendritic cells and predominantly occurs in children and young adults. The study aims to evaluate cytopathologic features and current diagnostic concepts in a large series of LCH on fine needle aspiration (FNA). STUDY DESIGN: We retrospectively searched the pathology archives of The Johns Hopkins Hospital (JHH) and Emory University Hospital (EUH) to identify all FNA cases diagnosed as LCH in a period of 21 years...
2017: Acta Cytologica
https://www.readbyqxmd.com/read/28401684/the-effects-of-smoking-status-and-smoking-history-on-patients-with-brain-metastases-from-lung-cancer
#14
Rachel F Shenker, Emory R McTyre, Jimmy Ruiz, Kathryn E Weaver, Christina Cramer, Natalie K Alphonse-Sullivan, Michael Farris, William J Petty, Marcelo R Bonomi, Kounosuke Watabe, Adrian W Laxton, Stephen B Tatter, Graham W Warren, Michael D Chan
There is limited data on the effects of smoking on lung cancer patients with brain metastases. This single institution retrospective study of patients with brain metastases from lung cancer who received stereotactic radiosurgery assessed whether smoking history is associated with overall survival, local control, rate of new brain metastases (brain metastasis velocity), and likelihood of neurologic death after brain metastases. Patients were stratified by adenocarcinoma versus nonadenocarcinoma histologies. Kaplan-Meier analysis was performed for survival endpoints...
May 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28391002/paravalvular-regurgitation-after-transcatheter-aortic-valve-replacement-comparing-transthoracic-versus-transesophageal-echocardiographic-guidance
#15
Salim S Hayek, Frank E Corrigan, Jose F Condado, Shuang Lin, Sharon Howell, James P MacNamara, Shuai Zheng, Patricia Keegan, Vinod Thourani, Vasilis C Babaliaros, Stamatios Lerakis
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is increasingly being performed in cardiac catheterization laboratories using transthoracic echocardiography (TTE) to guide valve deployment. The risk of paravalvular regurgitation (PVR) remains a concern. METHODS: We retrospectively reviewed 454 consecutive patients (mean age, 82 ± 8; 58% male) who underwent transfemoral TAVR at Emory Healthcare from 2007 to 2014. Two hundred thirty-four patients underwent TAVR in the cardiac catheterization laboratory with TTE guidance (TTE-TAVR; mean Society of Thoracic Surgeons score, 10%), while 220 patients underwent the procedure in the hybrid operating room with transesophageal echocardiography (TEE) guidance (TEE-TAVR; mean Society of Thoracic Surgeons score, 11%)...
June 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28385791/reader-training-for-the-re-staging-of-biochemically-recurrent-prostate-cancer-using-fluciclovine-18-f-pet-ct
#16
Matthew P Miller, Lale Kostakoglu, Daniel Pryma, Jian Qin Yu, Albert Chau, Eric Perlman, Bonnie Clarke, Donald Rosen, Penelope Ward
Fluciclovine ((18)F) is a novel positron emission tomography (PET)/computerised tomography (CT) tracer. This blinded image evaluation (BIE) sought to demonstrate that, after limited training, readers naïve to fluciclovine ((18)F), could interpret fluciclovine ((18)F) images from subjects with biochemical recurrent (BCR) prostate cancer with acceptable diagnostic performance and reproducibility. The primary objectives were to establish individual readers' diagnostic performance and the overall interpretation (2/3 reader concordance) compared to standard of truth (SOT) data (histopathology and/or clinical follow-up) and to evaluate inter-reader reproducibility...
April 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28381781/a-case-report-of-duodenal-obstruction-due-to-retroperitoneal-bleeding-after-the-rupture-of-a-lower-pancreaticoduodenal-artery-aneurysm
#17
Nobuhiro Takeuchi, Kazumasa Emori, Yusuke Nomura
We report a case of a patient with duodenal obstruction due to retroperitoneal bleeding after the rupture of a lower pancreaticoduodenal artery aneurysm. An 80-year-old female was admitted to our hospital because of nausea and vomiting. During hospitalization, she developed hemorrhagic shock. Enhanced computed tomography revealed retroperitoneal bleeding. Abdominal angiography revealed an 8-mm aneurysm of the lower pancreaticoduodenal artery, stenosis at the trunk of the celiac artery, and increased blood flow through the pancreaticoduodenal arcades from the superior mesenteric artery...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28364146/bundled-payments-in-total-joint-arthroplasty-and-spine-surgery
#18
REVIEW
Rashad Sullivan, Landry D Jarvis, Tadhg O'Gara, Maxwell Langfitt, Cynthia Emory
PURPOSE OF REVIEW: The goal of this manuscript is to provide an overview and analysis of bundled payment models for joint replacement and select spine procedures. Advantages and disadvantages of bundled payment models will be discussed. RECENT FINDINGS: In select populations, bundled payment models have been shown to reduce costs while maintaining satisfactory outcomes. These models have not been tested with complex patient cohorts, such as older adults with fragility hip fractures, and limited data exist with bundled payment analysis in spine procedures...
March 31, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28355625/predicting-rhesus-monkey-eye-movements-during-natural-image-search
#19
Mark A Segraves, Emory Kuo, Sara Caddigan, Emily A Berthiaume, Konrad P Kording
There are three prominent factors that can predict human visual-search behavior in natural scenes: the distinctiveness of a location (salience), similarity to the target (relevance), and features of the environment that predict where the object might be (context). We do not currently know how well these factors are able to predict macaque visual search, which matters because it is arguably the most popular model for asking how the brain controls eye movements. Here we trained monkeys to perform the pedestrian search task previously used for human subjects...
March 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28337725/comparison-of-diagnostic-performance-of-four-software-packages-for-phase-dyssynchrony-analysis-in-gated-myocardial-perfusion-spect
#20
Koichi Okuda, Kenichi Nakajima, Shinro Matsuo, Soichiro Kashiwaya, Hiroto Yoneyama, Takayuki Shibutani, Masahisa Onoguchi, Mitsumasa Hashimoto, Seigo Kinuya
BACKGROUND: Phase analysis of gated myocardial perfusion single-photon emission computed tomography (SPECT) for assessment of left ventricular (LV) dyssynchrony was investigated using the following dedicated software packages: Corridor4DM (4DM), cardioREPO (cREPO), Emory Cardiac Toolbox (ECTb), and quantitative gated SPECT (QGS). The purpose of this study was to evaluate the normal values of 95% histogram bandwidth, phase standard deviation (SD), and entropy and to compare the diagnostic performance of the four software packages...
December 2017: EJNMMI Research
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