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https://www.readbyqxmd.com/read/29142970/cardiovascular-disease-biomarkers-and-supar-in-predicting-decline-in-renal-function-a-prospective-cohort-study
#1
Salim S Hayek, Yi-An Ko, Mosaab Awad, Hina Ahmed, Brandon Gray, Kareem Mohammed Hosny, Hiroshi Aida, Melissa J Tracy, Changli Wei, Sanja Sever, Jochen Reiser, Arshed A Quyyumi
Introduction: Soluble urokinase-type plasminogen activator receptor (suPAR) strongly predicts outcomes and incident chronic kidney disease (CKD) in patients with cardiovascular disease (CVD). Whether the association between suPAR and CKD is a reflection of its overall association with chronic inflammation and poor CVD outcomes is unclear. We examined whether CVD biomarkers, including high-sensitivity C-reactive protein (hs-CRP), fibrin-degradation products (FDPs), heat-shock protein 70 (HSP-70), and high-sensitivity troponin I (hs-TnI) were associated with a decline in kidney function in the Emory Cardiovascular Biobank cohort, in which suPAR levels were shown to be predictive of both incident CKD and CVD outcomes...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29117312/association-of-overlapping-surgery-with-patient-outcomes-in-a-large-series-of-neurosurgical-cases
#2
Brian M Howard, Christopher M Holland, C Christina Mehta, Ganzhong Tian, David P Bray, Jason J Lamanna, James G Malcolm, Daniel L Barrow, Jonathan A Grossberg
Importance: Overlapping surgery (OS) is common. However, there is a dearth of evidence to support or refute the safety of this practice. Objective: To determine whether OS is associated with worsened morbidity and mortality in a large series of neurosurgical cases. Design, Setting, and Participants: A retrospective cohort study was completed for patients who underwent neurosurgical procedures at Emory University Hospital, a large academic referral hospital, between January 1, 2014, and December 31, 2015...
November 8, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29102347/relation-of-changes-in-body-fat-distribution-to-oxidative-stress
#3
Heval M Kelli, Frank E Corrigan, Robert E Heinl, Devinder S Dhindsa, Muhammad Hammadah, Ayman Samman-Tahhan, Pratik Sandesara, Wesley T O'Neal, Ibhar Al Mheid, Yi-An Ko, Viola Vaccarino, Thomas R Ziegler, Laurence S Sperling, Kenneth Brigham, Dean Jones, Greg S Martin, Arshed A Quyyumi
Android fat is a surrogate measure of visceral obesity in the truncal region. Both visceral adiposity and oxidative stress (OS) are linked to cardiometabolic risk factors and clinical cardiovascular disease. However, whether body fat distribution (android vs gynoid) is associated with OS remains unknown. We hypothesized that increased android fat will be associated with greater OS. Body fat distribution and markers of OS, including plasma levels of reduced (cysteine and glutathione) and oxidized (cystine and glutathione disulfide) aminothiols, were estimated in 711 volunteers (67% female, 23% black, mean age 48 ± 11) enrolled in the Emory Georgia Tech Predictive Health study...
September 20, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29096697/race-modifies-the-relationship-between-cognition-and-alzheimer-s-disease-cerebrospinal-fluid-biomarkers
#4
Jennifer C Howell, Kelly D Watts, Monica W Parker, Junjie Wu, Alexander Kollhoff, Thomas S Wingo, Cornelya D Dorbin, Deqiang Qiu, William T Hu
BACKGROUND: African Americans have been reported to have a higher prevalence of Alzheimer's disease (AD) than Caucasians, but etiology-specific AD biomarkers have not been systematically analyzed in older African Americans. Coexisting cerebrovascular disease may also contribute to this increased prevalence. We hypothesized that cerebrospinal fluid (CSF) biomarkers of amyloid, neurodegeneration, and endothelial dysfunction would differ between older African Americans and Caucasians with normal cognition and cognitive impairment associated with AD...
November 2, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29089340/genetic-variation-at-the-adamts7-locus-is-associated-with-reduced-severity-of-coronary-artery-disease
#5
Kenneth Chan, Xiangyuan Pu, Pratik Sandesara, Robin N Poston, Iain A Simpson, Arshed A Quyyumi, Shu Ye, Riyaz S Patel
BACKGROUND: Genome-wide association studies identified ADAMTS7 as a risk locus for coronary artery disease (CAD). Functional studies suggest that ADAMTS7 may promote cellular processes in atherosclerosis. We sought to examine the association between genetic variation at ADAMTS7 and measures of atherosclerosis using histological, angiographic, and clinical outcomes data. METHODS AND RESULTS: The lead CAD-associated single-nucleotide polymorphism rs3825807 at the ADAMTS7 locus was genotyped...
October 31, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29069611/metabolic-modeling-helps-interpret-transcriptomic-changes-during-malaria
#6
Yan Tang, Anuj Gupta, Swetha Garimalla, Mary R Galinski, Mark P Styczynski, Luis L Fonseca, Eberhard O Voit
Disease represents a specific case of malfunctioning within a complex system. Whereas it is often feasible to observe and possibly treat the symptoms of a disease, it is much more challenging to identify and characterize its molecular root causes. Even in infectious diseases that are caused by a known parasite, it is often impossible to pinpoint exactly which molecular profiles of components or processes are directly or indirectly altered. However, a deep understanding of such profiles is a prerequisite for rational, efficacious treatments...
October 22, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29069296/xmwas-a-data-driven-integration-and-differential-network-analysis-tool
#7
Karan Uppal, Chunyu Ma, Young-Mi Go, Dean P Jones
Summary: Integrative omics is a central component of most systems biology studies. Computational methods are required for extracting meaningful relationships across different omics layers. Various tools have been developed to facilitate integration of paired heterogenous omics data; however most existing tools allow integration of only two omics datasets. Furthermore, existing data integration tools do not incorporate additional steps of identifying sub-networks or communities of highly connected entities and evaluating the topology of the integrative network under different conditions...
October 23, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29052706/association-of-an-electroencephalography-based-risk-score-with-seizure-probability-in-hospitalized-patients
#8
Aaron F Struck, Berk Ustun, Andres Rodriguez Ruiz, Jong Woo Lee, Suzette M LaRoche, Lawrence J Hirsch, Emily J Gilmore, Jan Vlachy, Hiba Arif Haider, Cynthia Rudin, M Brandon Westover
Importance: Continuous electroencephalography (EEG) use in critically ill patients is expanding. There is no validated method to combine risk factors and guide clinicians in assessing seizure risk. Objective: To use seizure risk factors from EEG and clinical history to create a simple scoring system associated with the probability of seizures in patients with acute illness. Design, Setting, and Participants: We used a prospective multicenter (Emory University Hospital, Brigham and Women's Hospital, and Yale University Hospital) database containing clinical and electrographic variables on 5427 continuous EEG sessions from eligible patients if they had continuous EEG for clinical indications, excluding epilepsy monitoring unit admissions...
October 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29043554/evaluation-of-left-ventricular-mass-on-cadmium-zinc-telluride-imaging-validation-against-cardiac-magnetic-resonance
#9
Alessia Gimelli, Riccardo Liga, Serena Magro, Salvatore Novo, Roberto Pedrinelli, Anna Sonia Petronio, Paolo Marzullo, Alessia Pepe
BACKGROUND: Single-photon emission computed tomography has shown relevant limitations in the quantification of left ventricular (LV) mass. We sought to compare the estimates of LV mass on Cadmium-Zinc-Telluride (CZT) myocardial perfusion imaging (MPI) as compared to cardiac magnetic resonance (CMR). METHODS AND RESULTS: Twenty-five patients underwent MPI on a CZT camera and CMR on a 1.5 T scanner within 12 ± 3 weeks. LV mass was quantified on CZT images using two softwares: 4D-MSPECT (4DM) and Emory Cardiac Toolbox (ECTb)...
October 17, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29038247/constitutive-activation-of-integrin-%C3%AE-9-augments-self-directed-hyperplastic-and-proinflammatory-properties-of-fibroblast-like-synoviocytes-of-rheumatoid-arthritis
#10
Takashi Emori, Jun Hirose, Kotoko Ise, Jun-Ichiro Yomoda, Michiko Kasahara, Tadanobu Shinkuma, Hiroyuki Yoshitomi, Hiromu Ito, Motomu Hashimoto, Shingo Sugahara, Hirotada Fujita, Nobuchika Yamamoto, Yoshiaki Morita, Shuh Narumiya, Ichiro Aramori
Despite advances in the treatment of rheumatoid arthritis (RA), currently approved medications can have significant side effects due to their direct immunosuppressive activities. Additionally, current therapies do not address residual synovial inflammation. In this study, we evaluated the role of integrin α9 and its ligand, tenascin-C (Tn-C), on the proliferative and inflammatory response of fibroblast-like synoviocytes (FLSs) from RA patients grown in three-dimensional (3D)-micromass culture. FLSs from osteoarthritis patients, when grown in the 3D-culture system, formed self-directed lining-like structures, whereas FLSs from RA tissues (RA-FLSs) developed an abnormal structure of condensed cellular accumulation reflective of the pathogenic features of RA synovial tissues...
November 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29030383/12-week-24-7-ambulatory-artificial-pancreas-with-weekly-adaptation-of-insulin-delivery-settings-effect-on-hemoglobin-a1c-and-hypoglycemia
#11
Eyal Dassau, Jordan E Pinsker, Yogish C Kudva, Sue A Brown, Ravi Gondhalekar, Chiara Dalla Man, Steve Patek, Michele Schiavon, Vikash Dadlani, Isuru Dasanayake, Mei Mei Church, Rickey E Carter, Wendy C Bevier, Lauren M Huyett, Jonathan Hughes, Stacey Anderson, Dayu Lv, Elaine Schertz, Emma Emory, Shelly K McCrady-Spitzer, Tyler Jean, Paige K Bradley, Ling Hinshaw, Alejandro J Laguna Sanz, Ananda Basu, Boris Kovatchev, Claudio Cobelli, Francis J Doyle
OBJECTIVE: Artificial pancreas (AP) systems are best positioned for optimal treatment of type 1 diabetes (T1D) and are currently being tested in outpatient clinical trials. Our consortium developed and tested a novel adaptive AP in an outpatient, single-arm, uncontrolled multicenter clinical trial lasting 12 weeks. RESEARCH DESIGN AND METHODS: Thirty adults with T1D completed a continuous glucose monitor (CGM)-augmented 1-week sensor-augmented pump (SAP) period...
October 13, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29020226/innate-t-and-b-cell-responses-in-acute-human-zika-patients
#12
Lilin Lai, Nadine Rouphael, Yongxian Xu, Muktha S Natrajan, Allison Beck, Mari Hart, Matthew Feldhammer, Amanda Feldpausch, Charles Hill, Henry Wu, Jessica K Fairley, Pamela Lankford-Turner, Nicole Kasher, Patrick Rago, Yi-Juan Hu, Srilatha Edupuganti, Shital M Patel, Kristy O Murray, Mark J Mulligan
Background: There is an urgent need for studies of viral persistence and immunity during human Zika infections to inform planning and conduct of vaccine clinical trials. Methods: In five returned US travelers with acute symptomatic Zika infection, clinical features, viral RNA levels, and immune responses were characterized. Results: Two pregnant, flavivirus-experienced patients had viral RNA persist in plasma for >44 and >26 days. Three days after symptom onset transient increases in pro-inflammatory monocytes began followed at five days by transient decreases in myeloid dendritic cells...
August 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29018933/from-osteoimmunology-to-osteomicrobiology-how-the-microbiota-and-the-immune-system-regulate-bone
#13
REVIEW
Emory Hsu, Roberto Pacifici
Osteomicrobiology refers to the role of microbiota in bone health and the mechanisms by which the microbiota regulates post-natal skeletal development, bone aging, and pathologic bone loss. Here, we review recent reports linking gut microbiota to changes in bone phenotype. A pro-inflammatory cytokine milieu drives bone resorption in conditions such as sex steroid hormone deficiency. The response of the immune system to activation by the microbiome results in increased circulating osteoclastogenic cytokines in a T cell-dependent mechanism...
October 10, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29017278/favipiravir-and-ribavirin-treatment-of-epidemiologically-linked-cases-of-lassa-fever
#14
Vanessa N Raabe, Gerrit Kann, Bruce S Ribner, Andres Morales, Jay B Varkey, Aneesh K Mehta, G Marshall Lyon, Sharon Vanairsdale, Kelly Faber, Stephan Becker, Markus Eickmann, Thomas Strecker, Shelley Brown, Ketan Patel, Philipp De Leuw, Gundolf Schuettfort, Christoph Stephan, Holger Rabenau, John D Klena, Pierre E Rollin, Anita McElroy, Ute Ströher, Stuart Nichol, Colleen S Kraft, Timo Wolf
Two patients with Lassa fever are described who are the first human cases treated with a combination of ribavirin and favipiravir. Both patients survived but developed transaminitis and had prolonged detectable virus RNA in blood and semen, suggesting that the possibility of sexual transmission of Lassa virus should be considered.
September 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28988402/nutritional-markers-may-identify-patients-with-greater-risk-of-re-admission-after-geriatric-hip-fractures
#15
Austin V Stone, Alexander Jinnah, Brian J Wells, Hal Atkinson, Anna N Miller, Wendell M Futrell, Kristin Lenoir, Cynthia L Emory
PURPOSE: Osteoporotic hip fractures are increasing in prevalence with the growing elderly population. Morbidity and mortality remain high following osteoporotic hip fractures despite advances in medical and surgical treatments. The associated costs and medical burdens are increased with a re-admission following hip fracture treatment. This study sought to identify demographic and clinical values that may be a predictive model for 30-day re-admission risk following operative management of an isolated hip fracture...
October 7, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28973432/staged-stereotactic-radiosurgery-for-large-brain-metastases-local-control-and-clinical-outcomes-of-a-one-two-punch-technique
#16
Ammoren Dohm, Emory R McTyre, Catherine Okoukoni, Adrianna Henson, Christina K Cramer, Michael C LeCompte, Jimmy Ruiz, Michael T Munley, Shadi Qasem, Hui-Wen Lo, Fei Xing, Kounosuke Watabe, Adrian W Laxton, Stephen B Tatter, Michael D Chan
BACKGROUND: Treatment options are limited for large, unresectable brain metastases. OBJECTIVE: To report a single institution series of staged stereotactic radiosurgery (SRS) that allows for tumor response between treatments in order to optimize the therapeutic ratio. METHODS: Patients were treated with staged SRS separated by 1 mo with a median dose at first SRS of 15 Gy (range 10-21 Gy) and a median dose at second SRS of 14 Gy (range 10-18 Gy)...
July 7, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28963176/from-albania-to-zimbabwe-surveying-10-years-of-summer-field-experiences-at-the-rollins-school-of-public-health
#17
Evelyn L Howatt Donahoe, Roger W Rochat, Deborah McFarland, Carlos Del Rio
The objective of this article is to describe summer field experiences at the Rollins School of Public Health. An online survey was conducted among Master of Public Health students returning from summer field experiences. We used printed reports from 2004-2012 and original survey data from 2010-2013 to perform a trend analysis using correlation analysis and linear regression. We found that our students have worked for more than 300 organizations in 84 countries. The average cost of a summer field experience fluctuated around US$3,500, with students receiving an average of US$2,180 in funding...
September 27, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28959457/hemangioma-of-the-rib-showing-a-relatively-high-18f-fdg-uptake-a-case-report-with-a-literature-review
#18
Takahide Itabashi, Makoto Emori, Yoshinori Terashima, Tadashi Hasegawa, Junya Shimizu, Satoshi Nagoya, Toshihiko Yamashita
Hemangioma of the rib is a rare benign tumor that is often difficult to distinguish from malignant bone tumors. Rib hemangioma often shows bony disruption with a slight cortical disruption, extraosseous lesion, and expanded bone on computed tomography (CT). We report the case of a 68-year-old man with atypical rib hemangioma with a slight cortical disruption and no expanded bone. The tumor showed relatively high 18FDG-uptake on positron emission tomography (PET)/CT. Rib hemangioma often shows higher 18FDG-uptake...
September 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28956317/the-role-of-nuclear-medicine-in-assessments-of-cardiac-dyssynchrony
#19
Masanao Naya, Osamu Manabe, Kazuhiro Koyanagawa, Nagara Tamaki
Radionuclide imaging has an advantage for quantitative analyses of the tracer concentration and its temporal changes. Myocardial perfusion and function have been adapted for synchrony analyses. Extracted parameters have been demonstrated to measure ventricular synchrony and even to predict CRT outcomes. ERNA has the advantages of higher temporal resolution, greater reproducibility, and the volumetric analysis of both ventricles that can be applied for analyses of intraventricular synchrony and interventricular synchrony...
September 27, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28945361/multifunctional-magnetic-and-upconverting-nanobeads-as-dual-modal-imaging-tools
#20
Maria Elena Materia, Manuel Pernia Leal, Marco Scotto, Preethi Bala Balakrishnan, Sahitya Kumar Avugadda, María L García-Martín, Bruce E Cohen, Emory M Chan, Teresa Pellegrino
We report the fabrication of aqueous multimodal imaging nanocomposites based on superparamagnetic nanoparticles (MNPs) and two different sizes of photoluminescent upconverting nanoparticles (UCNPs). The controlled and simultaneous incorporation of both types of nanoparticles (NPs) was obtained by controlling the solvent composition and the addition rate of the destabilizing solvent. The magnetic properties of the MNPs remained unaltered after their encapsulation into the polymeric beads as shown by the T2 relaxivity measurements...
November 2, 2017: Bioconjugate Chemistry
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