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Alessandra Maria Mont Alverne Pierre, Ana Cristina de Castro Amaral Feldner, Roberto José de Carvalho Filho, Edmundo Pessoa de Almeida Lopes, Michele Soares Gomes Gouvea, João Renato Rebello Pinho, Claudia Teresa Carvente, Christini Takemi Emori, Genimari Arruda da Silva, Maria Lúcia Cardoso Gomes Ferraz
INTRODUCTION: Hepatitis B virus infection is an important cause of liver disease in hemodialysis patients and renal transplant recipients. Hepatitis Delta virus is a defective virus transmitted by the same route of hepatitis B virus, which requires the helper function of hepatitis B virus. Data about hepatitis B virus/hepatitis delta virus coinfection are scarce and there are no studies regarding the coinfection among hemodialysis patients and renal transplant in our country. OBJECTIVE: This study aimed to investigate the prevalence of hepatitis delta virus infection among hemodialysis patients and renal transplant recipients...
March 2018: International Journal of Artificial Organs
Kristen Emory, Francisco O Buchting, Dennis R Trinidad, Lisa Vera, Sherry L Emery
Background: LGBT populations use tobacco at disparately higher rates nationwide, compared to national averages. The tobacco industry has a history targeting LGBT with marketing efforts, likely contributing to this disparity. This study explores whether exposure to tobacco content on traditional and social media is associated with tobacco use among LGBT and non-LGBT. Methods: This study reports results from LGBT (N=1,092) and non-LGBT (N=16,430) respondents to a 2013 nationally representative cross-sectional online survey of US adults (N=17,522)...
March 12, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Patricio Riva-Posse, Collin R Reiff, Johnathan A Edwards, Gregory P Job, Gail C Galendez, Steven J Garlow, Tammy C Saah, Boadie W Dunlop, William M McDonald
BACKGROUND: The dissociative anesthetic agent ketamine is increasingly being utilized to treat depression, despite not having FDA (Food and Drug Administration) approval for this indication. There are many questions about the potential risks of this treatment and hence the proper setting and degree of monitoring required to ensure patient safety. There is limited data about the cardiovascular safety of ketamine when administered at subanesthetic doses to treat depression. METHODS: 66 patients in the Department of Psychiatry at Emory University received a total of 684 ketamine infusions between 2014 and 2016...
February 21, 2018: Journal of Affective Disorders
Teng Fei, Tengjiao Zhang, Weiyang Shi, Tianwei Yu
Motivation: It is well known that batch effects exist in RNA-seq data and other profiling data. Although some methods do a good job adjusting for batch effects by modifying the data matrices, it is still difficult to remove the batch effects entirely. The remaining batch effect can cause artifacts in the detection of patterns in the data. Results: In this study, we consider the batch effect issue in the pattern detection among the samples, such as clustering, dimension reduction, and construction of networks between subjects...
March 1, 2018: Bioinformatics
Hiroyuki Tsuchie, Makoto Emori, Hiroyuki Nagasawa, Naohisa Miyakoshi, Yasutaka Murahashi, Emi Mizushima, Toshihiko Yamashita, Yoichi Shimada
BACKGROUND: Soft tissue sarcoma (STS) mainly occurs in middle-aged and senior citizens. Although a poorer prognosis has been reported for older patients, few studies have examined advanced elderly excessive older patients. We evaluated the clinical features of advanced elderly patients with STS. METHODS: One hundred and forty-four patients were included in this retrospective study, and we divided them into two groups based on a cut-off age of 85 (older and younger groups)...
February 27, 2018: International Journal of Clinical Oncology
Abhinav Koul, Anand C Baxi, Ruilian Shang, Xianmei Meng, Lianyong Li, Steven A Keilin, Field F Willingham, Qiang Cai
Background: Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) has become the preferred method to diagnose pancreatic masses due to its minimally invasive approach and diagnostic accuracy. Many studies have shown that rapid on-site evaluation (ROSE) improves diagnostic yield by 10-30%; however, more recent studies have demonstrated effective diagnostic accuracy rates without ROSE. Our study aims to examine whether the current standard of performing ROSE after each FNA pass adds diagnostic value during EUS-guided FNA of pancreatic masses...
February 2018: Gastroenterology Report
Christina M Correnti, Suephy C Chen, Benjamin K Stoff
BACKGROUND: Video-based patient education about long-term systemic corticosteroid treatment has not been assessed. OBJECTIVE: To compare video-based versus verbal education in patient knowledge gained and satisfaction. METHODS: English-speaking adults (≥18 years) were recruited from March-August 2013 from medical dermatology clinics. Study provider clinics were the unit of randomization. Verbal subjects heard a script based on the standard discussions of two top systemic corticosteroid prescribers at Emory...
September 15, 2017: Dermatology Online Journal
Hugh A Stoddard, Erica D Brownfield
PROBLEM: Undergraduate medical education (UME) has trended toward outcomes-based education, unveiling new issues for UME program organization and leadership. Using a common language for categorizing and linking all program components is essential. The Emory Curriculum Alignment Taxonomy (ECAT) was designed as a common vocabulary for curriculum mapping in the outcomes-based environment of the Emory University School of Medicine. APPROACH: The ECAT, developed in 2016, uses a set of 291 controlled identifiers, or "tags," to describe every educational activity's content, instruction, assessment, and outcomes, and thereby to align teaching inputs with student outcomes...
February 20, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
Michael C LeCompte, Emory McTyre, Adrianna Henson, Michael Farris, Catherine Okoukoni, Christina K Cramer, Pierre Triozzi, Jimmy Ruiz, Kounosuke Watabe, Hui-Wen Lo, Michael T Munley, Adrian W Laxton, Stephen B Tatter, Xiaobo Zhou, Michael Chan
Introduction The roles of early whole brain radiotherapy (WBRT) and upfront stereotactic radiosurgery (SRS) alone in the treatment of melanoma patients with brain metastasis remain uncertain. We investigated the volumetric kinetics of brain metastasis development and associations with clinical outcomes for melanoma patients who received upfront SRS alone. Methods Volumetric brain metastasis velocity (vBMV) was defined as the volume of new intracranial disease at the time of distant brain failure (DBF) for the first DBF (DBF1) and second DBF (DBF2) averaged over the time since initial or most recent SRS...
December 11, 2017: Curēus
Kaley Ann Sheppard, David Emory Rival
A bio-inspired, slotted delta wing was abstracted from a multi-vane propulsor geometry ubiquitous in nature, and analysed to investigate aerodynamic performance during acceleratory and steady-state motions. Evolutionary convergence of slotted geometries in nature suggests an aerodynamic benefit in manoeuvrability, as exemplified in the fins and wings of a broad range of extant and extinct swimmers and flyers, respectively. Through direct force measurements and stereoscopic particle image velocimetry, it was found that the abstracted, slotted geometry exhibited a region of steady-state lift and drag enhancement at angles of attack greater than 25° when compared to a reference profile based on a delta-wing plate...
February 15, 2018: Bioinspiration & Biomimetics
Dharmender Malik, Ashwani Sood, Madan Parmar, Bhagwant Rai Mittal
Background: Phase analysis can be easily performed by different software to assess the left ventricular dyssynchrony from gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) with high precision. However, the normal values of histogram bandwidth (HBW) and phase standard deviation (PSD) and their comparison using different programs have not been fully elucidated and actively being evaluated at present. The aim of this study was to determine the phase analysis parameters values and to compare the phase indices of two commonly used programs in a group of patients with normal gated SPECT-MPI...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
G Shankar Ganesh, Ranjita Kumari, Monalisa Pattnaik, Patitapaban Mohanty, Chittaranjan Mishra, Parminder Kaur, Anandhi Dakshinamoorthy
BACKGROUND AND PURPOSE: Spasticity is a major disabling symptom in patients post stroke. Though studies have demonstrated that electrical stimulation (ES) can reduce spasticity and improve passive ankle range of motion (ROM), not many studies have evaluated the effectiveness of ES on active ankle ROM. The purpose of this study was to determine the effectiveness of Faradic and Russian currents in the reduction of ankle plantar-flexor spasticity and improving motor recovery in patients post stroke...
February 8, 2018: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
Bhakti Dwivedi, Jeanne Kowalski
While many methods exist for integrating multi-omics data or defining gene sets, there is no one single tool that defines gene sets based on merging of multiple omics data sets. We present shinyGISPA, an open-source application with a user-friendly web-based interface to define genes according to their similarity in several molecular changes that are driving a disease phenotype. This tool was developed to help facilitate the usability of a previously published method, Gene Integrated Set Profile Analysis (GISPA), among researchers with limited computer-programming skills...
2018: PloS One
Melat Gebre, Anna Woodbury, Vitaly Napadow, Venkatagiri Krishnamurthy, Lisa C Krishnamurthy, Roman Sniecinski, Bruce Crosson
BACKGROUND: Fibromyalgia is a chronic pain state that includes widespread musculoskeletal pain, fatigue, psychiatric symptoms, cognitive and sleep disturbances, and multiple somatic symptoms. Current therapies are often insufficient or come with significant risks, and while there is an increasing demand for non-pharmacologic and especially non-opioid pain management such as that offered through complementary and alternative medicine therapies, there is currently insufficient evidence to recommend these therapies...
February 6, 2018: JMIR Research Protocols
Sherif G Nour, Jonathan S Lewin
The expansive technological developments that occurred over the past decades have clearly moved the field of Interventional MRI beyond the arena of the "proof of concept" to a viable option for minimally invasive diagnosis and therapy. State-of-the-art MRI technology can currently be employed to identify an occult target pathology, confidently steer an interventional device into complex anatomy, accurately deliver a device, drug, or energy, and/or monitor the real time effect of a treatment. Implementing a full-scope interventional MRI service requires substantial physical and conceptual modifications of the traditional diagnostic MRI environment...
February 2018: Topics in Magnetic Resonance Imaging: TMRI
Mehmet Asim Bilen, Giselle Marie Almeida Dutcher, Yuan Liu, Deepak Ravindranathan, Haydn T Kissick, Bradley C Carthon, Omer Kucuk, Wayne B Harris, Viraj A Master
BACKGROUND: Biomarkers to guide treatment in metastatic renal-cell carcinoma (mRCC) are lacking. We aimed to investigate the association between pretreatment neutrophil-to-lymphocyte ratio (NLR) and outcome of patients with mRCC receiving nivolumab. PATIENTS AND METHODS: Through retrospective chart review, we identified 38 patients with mRCC treated with standard-of-care nivolumab between 2015 and 2016 at Winship Cancer Institute of Emory University. NLR was determined from complete blood count collected before starting treatment, and imaging was performed to assess progression...
January 4, 2018: Clinical Genitourinary Cancer
Qiang Cui, Stephan Irle, Jamal Musaev
Keiji Morokuma, William Henry Emerson Professor Emeritus of Emory University and Research Leader at the Fukui Institute for Fundamental Chemistry, Kyoto University, passed away at the age of 83 on November 27, 2017. Morokuma made numerous contributions to theoretical methodologies for the determination of reaction mechanisms and the understanding of intermolecular interactions.
February 2, 2018: Angewandte Chemie
Frank E Corrigan, Xiao Zhou, John C Lisko, Salim S Hayek, Ioannis Parastatidis, Patricia Keegan, Sharon Howell, Vinod Thourani, Vasilis C Babaliaros, Stamatios Lerakis
BACKGROUND: Global longitudinal strain (GLS) has incremental value in assessing left ventricular (LV) function in severe aortic stenosis and is related to clinical outcome after transcatheter aortic valve replacement (TAVR). We sought to identify relevant echocardiographic predictors of GLS improvement and myocardial function recovery after TAVR. METHODS: We analyzed baseline and 12-month follow-up echocardiograms for LV strain analysis from 123 patients who underwent at Emory University Hospital with the Edwards SAPIEN valve between 7/2007 and 7/2013...
January 25, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
Yan Xu, Keliang Chen, Qianhua Zhao, Qihao Guo
BACKGROUND: The present study was conducted to detect neuropsychological differences and to identify discriminators between mild dementia with L ewy bodies (DLB ) and mild A lzheimer's disease (AD ). METHODS: The present study included 37 mild DLB patients, 48 mild AD patients, and 80 healthy elderly individuals. A comprehensive battery of neuropsychological tests was administrated to assess their cognitive function. Linear stepwise discriminant analysis was used to identify the neuropsychological measures with values that could differentiate between mild DLB and mild AD ...
January 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Luciana Paula Maximino, Ticiana Cristina de Freitas Zambonato, Mirela Machado Picolini-Pereira, Camila de Castro Corrêa, Mariza Ribeiro Feniman, Wanderléia Quinhoneiro Blasca
Introduction  Cleft lip and cleft palate can result in impairments in communication, specifically in hearing, making the use of technological resources such as blogs a fundamental guideline for health professionals. Objective  The aim of this study was to prepare and analyze the access to a blog about cleft lip and cleft palate and hearing as a pedagogical tool for health professionals. Methods  The first stage for the development of the blog was the selection of the content that would be addressed and the respective illustrations...
January 2018: International Archives of Otorhinolaryngology
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