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https://www.readbyqxmd.com/read/28699227/implication-of-chemo-resistant-memory-t-cells-for-immune-surveillance-in-patients-with-sarcoma-receiving-chemotherapy
#1
Yuji Shibayama, Tomohide Tsukahara, Makoto Emori, Kenji Murata, Emi Mizushima, Yoshihiko Hirohashi, Takayuki Kanaseki, Munehide Nakatsugawa, Terufumi Kubo, Toshihiko Yamashita, Noriyuki Sato, Toshihiko Torigoe
Chemotherapy has improved the prognosis of patients with sarcomas. However, it may suppress anti-tumor immunity. Recently, we reported a novel CD8(+) memory T cell population with a chemo-resistance property, "young memory" T (TYM ) cells. In this study, we investigated the proportion and function of TYM cells in peripheral blood of healthy donors and sarcoma patients who received chemotherapy and those who did not. The proportion of TYM cells was significantly decreased in patients compared with that in healthy donors...
July 12, 2017: Cancer Science
https://www.readbyqxmd.com/read/28691378/coexistence-of-low-damping-and-strong-magnetoelastic-coupling-in-epitaxial-spinel-ferrite-thin-films
#2
Satoru Emori, Benjamin A Gray, Hyung-Min Jeon, Joseph Peoples, Maxwell Schmitt, Krishnamurthy Mahalingam, Madelyn Hill, Michael E McConney, Matthew T Gray, Urusa S Alaan, Alexander C Bornstein, Padraic Shafer, Alpha T N'Diaye, Elke Arenholz, Greg Haugstad, Keng-Yuan Meng, Fengyuan Yang, Dongyao Li, Sushant Mahat, David G Cahill, Pallavi Dhagat, Albrecht Jander, Nian X Sun, Yuri Suzuki, Brandon M Howe
Low-loss magnetization dynamics and strong magnetoelastic coupling are generally mutually exclusive properties due to opposing dependencies on spin-orbit interactions. So far, the lack of low-damping, magnetostrictive ferrite films has hindered the development of power-efficient magnetoelectric and acoustic spintronic devices. Here, magnetically soft epitaxial spinel NiZnAl-ferrite thin films with an unusually low Gilbert damping parameter (<3 × 10(-3) ), as well as strong magnetoelastic coupling evidenced by a giant strain-induced anisotropy field (≈1 T) and a sizable magnetostriction coefficient (≈10 ppm), are reported...
July 10, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28666680/the-safety-immunogenicity-and-acceptability-of-inactivated-influenza-vaccine-delivered-by-microneedle-patch-tiv-mnp-2015-a-randomised-partly-blinded-placebo-controlled-phase-1-trial
#3
Nadine G Rouphael, Michele Paine, Regina Mosley, Sebastien Henry, Devin V McAllister, Haripriya Kalluri, Winston Pewin, Paula M Frew, Tianwei Yu, Natalie J Thornburg, Sarah Kabbani, Lilin Lai, Elena V Vassilieva, Ioanna Skountzou, Richard W Compans, Mark J Mulligan, Mark R Prausnitz
BACKGROUND: Microneedle patches provide an alternative to conventional needle-and-syringe immunisation, and potentially offer improved immunogenicity, simplicity, cost-effectiveness, acceptability, and safety. We describe safety, immunogenicity, and acceptability of the first-in-man study on single, dissolvable microneedle patch vaccination against influenza. METHODS: The TIV-MNP 2015 study was a randomised, partly blinded, placebo-controlled, phase 1, clinical trial at Emory University that enrolled non-pregnant, immunocompetent adults from Atlanta, GA, USA, who were aged 18-49 years, naive to the 2014-15 influenza vaccine, and did not have any significant dermatological disorders...
June 27, 2017: Lancet
https://www.readbyqxmd.com/read/28665189/schools-must-include-faculty-and-staff-in-sexual-violence-prevention-efforts
#4
Jessica Sales, Kathleen Krause
Creating a normative campus environment intolerant to sexual violence is important for prevention. While prevention initiatives focusing on students are vital, faculty and staff have a central role in supporting and sustaining a comprehensive strategy for preventing campus sexual violence. Nationwide, colleges and universities recently implemented campus climate surveys. At Emory, we decided to survey faculty and staff as well as students, motivated by our use of an ecological framing of campus sexual violence...
June 30, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28643914/the-use-of-cell-culture-platforms-to-identify-novel-markers-of-bone-and-dentin-resorption
#5
W J Rody, O Krokhin, V Spicer, C A Chamberlain, M Chamberlain, K P McHugh, S M Wallet, A K Emory, J D Crull, L S Holliday
OBJECTIVES: 1) To test the hypothesis that there would be proteomic differences in the composition of exosomes isolated from osteoclasts and odontoclasts and 2) to determine the clinical usefulness of these in vitro biomarker candidates. MATERIALS AND METHODS: Mouse bone marrow-derived precursors were cultured on either dentin or bone slices and allowed to mature and begin resorption. Exosomes were isolated from cell culture media and characterized by mass spectrometry...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28636442/the-national-ebola-training-and-education-center-preparing-the-united-states-for-ebola-and-other-special-pathogens
#6
Christopher J Kratochvil, Laura Evans, Bruce S Ribner, John J Lowe, Melissa Cole Harvey, Richard C Hunt, Abbigail J Tumpey, Ryan P Fagan, Michelle M Schwedhelm, Sonia Bell, John Maher, Colleen S Kraft, Nicholas V Cagliuso, Sharon Vanairsdale, Angela Vasa, Philip W Smith
The National Ebola Training and Education Center (NETEC) was established in 2015 in response to the 2014-2016 Ebola virus disease outbreak in West Africa. The US Department of Health and Human Services office of the Assistant Secretary for Preparedness and Response and the US Centers for Disease Control and Prevention sought to increase the competency of healthcare and public health workers, as well as the capability of healthcare facilities in the United States, to deliver safe, efficient, and effective care to patients infected with Ebola and other special pathogens nationwide...
May 2017: Health Security
https://www.readbyqxmd.com/read/28633723/validated-measures-of-insomnia-function-sleepiness-and-nasal-obstruction-in-a-cpap-alternatives-clinic-population
#7
Austin S Lam, Nancy A Collop, Donald L Bliwise, Raj C Dedhia
STUDY OBJECTIVES: Although efficacious in the treatment of obstructive sleep apnea (OSA), continuous positive airway pressure (CPAP) can be difficult to tolerate, with long-term adherence rates approaching 50%. CPAP alternatives clinics specialize in the evaluation and treatment of CPAP-intolerant patients; yet this population has not been studied in the literature. To better understand these patients, we sought to assess insomnia, sleep-related functional status, sleepiness, and nasal obstruction, utilizing data from validated instruments...
June 16, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28618965/time-dependent-effects-of-prognostic-biomarkers-of-systemic-inflammation-in-patients-with-metastatic-renal-cell-carcinoma
#8
Wayne B Harris, Chao Zhang, Yuan Liu, Dale K Robertson, Mikhail Y Akbashev, Brian M Lingerfelt, Omer Kucuk, Bradley C Carthon, Theresa W Gillespie, Adeboye O Osunkoya, Viraj A Master
The goal of this study was to examine time-dependent effects of prognostic biomarkers of systemic inflammation in patients with metastatic renal cell carcinoma. Retrospective chart reviews were conducted at the Winship Cancer Institute of Emory University and the Atlanta Veterans Administration Medical Center with authorization from the Emory University Institutional Review Board and the Veterans Administration Research and Development Committee. Inclusion criteria included age ⩾18 years, treatment with targeted therapy for clear cell or non-clear cell metastatic renal cell carcinoma and concomitant assessment of C-reactive protein and albumin levels on ⩾3 occasions that were ⩾10 days apart...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28596100/aerodynamic-patterns-in-patients-with-voice-disorders-a-retrospective-study
#9
Marina Gilman, Brian Petty, Carissa Maira, Madeleine Pethan, Lijia Wang, Edie R Hapner, Michael M Johns
OBJECTIVE: A recently published retrospective chart review of aerodynamic profiles of women with primary muscle tension dysphonia by Gillespie et al (2013) identified various relationships between mean airflow rate (MFR) and estimated subglottal pressure (est-Psub). The current retrospective study expanded the diagnostic categories to include all voice disorders referred for voice therapy. Three research questions were proposed: (1) Are there differences in the MFR and the est-Psub compared with the normal control group? (2) Within the disordered population, are there different variations in the pairing of MFR and est-Psub? (3) If these variations exist, are they diagnosis specific? METHODS: A retrospective chart review of patients seen for acoustic and aerodynamic voice assessment at the Emory Voice Center between January 1, 2013 and December 31, 2014, were examined for aerodynamic measures of est-Psub and MFR; of these, 192 met the inclusion criteria...
June 5, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28586952/brain-metastasis-velocity-a-novel-prognostic-metric-predictive-of-overall-survival-and-freedom-from-whole-brain-radiation-therapy-after-distant-brain-failure-following-upfront-radiosurgery-alone
#10
Michael Farris, Emory R McTyre, Christina K Cramer, Ryan Hughes, David M Randolph, Diandra N Ayala-Peacock, J Daniel Bourland, Jimmy Ruiz, Kounosuke Watabe, Adrian W Laxton, Stephen B Tatter, Xiaobo Zhou, Michael D Chan
PURPOSE: Prior statistical models attempted to identify risk factors for time to distant brain failure (DBF) or time to salvage whole-brain radiation therapy (WBRT) to predict the benefit of early WBRT versus stereotactic radiosurgery (SRS) alone. We introduce a novel clinical metric, brain metastasis velocity (BMV), for predicting clinical outcomes after initial DBF following upfront SRS alone. METHODS AND MATERIALS: BMV was defined as the cumulative number of new brain metastases that developed over time since first SRS in years...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28583908/emory-s-winship-earns-comprehensive-status
#11
(no author information available yet)
Emory University's Winship Cancer Institute in Atlanta, GA, has been granted Comprehensive Cancer Center status, the NCI's highest designation. The center was particularly recognized for its population-based research and extensive clinical trials program.
June 5, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28581405/external-validity-of-a-risk-stratification-score-predicting-early-distant-brain-failure-and-salvage-whole-brain-radiation-therapy-after-stereotactic-radiosurgery-for-brain-metastases
#12
Robert H Press, Danielle M Boselli, James T Symanowski, Scott P Lankford, Robert J McCammon, Benjamin J Moeller, John H Heinzerling, Carolina E Fasola, Stuart H Burri, Kirtesh R Patel, Anthony L Asher, Ashley L Sumrall, Walter J Curran, Hui-Kuo G Shu, Ian R Crocker, Roshan S Prabhu
BACKGROUND: A scoring system using pretreatment factors was recently published for predicting the risk of early (≤6 months) distant brain failure (DBF) and salvage whole brain radiation therapy (WBRT) after stereotactic radiosurgery (SRS) alone. Four risk factors were identified: (1) lack of prior WBRT; (2) melanoma or breast histologic features; (3) multiple brain metastases; and (4) total volume of brain metastases <1.3 cm(3), with each factor assigned 1 point. The purpose of this study was to assess the validity of this scoring system and its appropriateness for clinical use in an independent external patient population...
July 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28571577/protocol-for-the-emory-university-african-american-vaginal-oral-and-gut-microbiome-in-pregnancy-cohort-study
#13
Elizabeth J Corwin, Carol J Hogue, Bradley Pearce, Cherie C Hill, Timothy D Read, Jennifer Mulle, Anne L Dunlop
BACKGROUND: Adverse birth and neonatal outcomes disproportionately affect African American women and infants compared to those of other races/ethnicities. While significant research has sought to identify underlying factors contributing to these disparities, current understanding remains limited, constraining prevention, early diagnosis, and treatment. With the development of next generation sequencing techniques, the contribution of the vaginal microbiome to adverse maternal and neonatal outcomes has come under consideration...
June 1, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28537447/hypocretin-measurement-shelf-age-of-radioimmunoassay-kit-but-not-freezer-time-influences-assay-variability
#14
Glenda Keating, Donald L Bliwise, Prabhjyot Saini, David B Rye, Lynn Marie Trotti
The hypothalamic peptide hypocretin 1 (orexin A) may be assayed in cerebrospinal fluid to diagnose narcolepsy type 1. This testing is not commercially available, and factors contributing to assay variability have not previously been comprehensively explored. In the present study, cerebrospinal fluid hypocretin concentrations were determined in duplicate in 155 patient samples, across a range of sleep disorders. Intra-assay variability of these measures was analyzed. Inter-assay correlation between samples tested at Emory and at Stanford was high (r = 0...
May 24, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28536486/emerging-indications-for-fractionated-gamma-knife-radiosurgery
#15
Emory McTyre, Corbin A Helis, Michael Farris, Lisa Wilkins, Darrell Sloan, William H Hinson, J Daniel Bourland, William A Dezarn, Michael T Munley, Kounosuke Watabe, Fei Xing, Adrian W Laxton, Stephen B Tatter, Michael D Chan
BACKGROUND: Gamma Knife radiosurgery (GKRS) allows for the treatment of intracranial tumors with a high degree of dose conformality and precision. There are, however, certain situations wherein the dose conformality of GKRS is desired, but single session treatment is contraindicated. In these situations, a traditional pin-based GKRS head frame cannot be used, as it precludes fractionated treatment. OBJECTIVE: To report our experience in treating patients with fractionated GKRS using a relocatable, noninvasive immobilization system...
February 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28532575/readmission-rates-after-transcatheter-aortic-valve-replacement-in-high-and-extreme-risk-patients-with-severe-aortic-stenosis
#16
Jessica Forcillo, Jose F Condado, Jose N Binongo, Yi Lasanajak, Hope Caughron, Vasilis Babaliaros, Chandan Devireddy, Bradley Leshnower, Robert A Guyton, Peter C Block, Amy Simone, Patricia Keegan, Paul Khairy, Vinod H Thourani
OBJECTIVE: In high- or extreme-risk patients undergoing transcatheter aortic valve replacement, readmissions have not been adequately studied and are the subject of increased scrutiny by healthcare systems. The objectives of this study were to determine the incidence of 30-day and 1-year cardiac and noncardiac readmissions, identify predictors of readmission, and assess the association between readmission and 1-year mortality. METHODS: A retrospective review was performed on 714 patients who underwent transcatheter aortic valve replacement from September 2007 to January 2015 at Emory University...
August 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28511975/leptomeningeal-failure-in-patients-with-breast-cancer-receiving-stereotactic-radiosurgery-for-brain-metastases
#17
REVIEW
Edina C Wang, Andrew J Huang, Karen E Huang, Emory R McTyre, Hui-Wen Lo, Kounosuke Watabe, Linda Metheny-Barlow, Adrian W Laxton, Stephen B Tatter, Roy E Strowd, Michael D Chan, Brandi R Page
PURPOSE: Prior studies suggest a high incidence of leptomeningeal failure (LMF) in breast cancer metastatic to brain. This study examines breast cancer-specific variables affecting development of LMF and survival after Gamma-Knife Radiosurgery (GKS). METHODS: Between 2000-2010, 149 (breast) and 658 other-histology patients were treated with GKS. Hormone/HER2, age, local/distant brain failure, prior craniotomy, and prior whole-brain radiotherapy (WBRT) were assessed...
May 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28481592/luciano-l-abate-1928-2016
#18
Robert Henley Woody
This article memorializes Luciano L'Abate (1928 -2016). In 1964, L'Abate became an assistant professor of medical psychology at the Washington University School of Medicine and, in 1965, an associate professor of pediatrics in the Emory University School of Medicine. He then transitioned to the Georgia State University (GSU), where he was promoted to professor of psychology. From 1965 to 1990, he served as director of the Family Psychology Program and Family Study Center at GSU. In retirement, L'Abate increased his writing and lecturing...
May 2017: American Psychologist
https://www.readbyqxmd.com/read/28474107/-foot-drop-treatment-by-implantation-of-a%C3%A2-neuroprosthesis-actigait%C3%A2
#19
D Yao, E Jakubowitz, S Ettinger, C Plaass, C Stukenborg-Colsman, K Daniilidis
OBJECTIVE: Gait improvement by restoring dorsiflexion using a neuroprosthesis implant. INDICATIONS: Foot drop with damage to the 1st motor neuron; passive mobility in ankle is possible; adult patients. CONTRAINDICATIONS: Foot drop with peripheral damage and injury to the peroneal nerve; already implanted stimulators (e.g., defibrillator, pacemaker, or pain stimulator); severe anesthesia risks in multimorbid patients. SURGICAL TECHNIQUE: Surgery in lateral position...
May 4, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28472248/accounting-for-tumor-purity-improves-cancer-subtype-classification-from-dna-methylation-data
#20
Weiwei Zhang, Hao Feng, Hao Wu, Xiaoqi Zheng
Motivation: Tumor sample classification has long been an important task in cancer research. Classifying tumors into different subtypes greatly benefits therapeutic development and facilitates application of precision medicine on patients. In practice, solid tumor tissue samples obtained from clinical settings are always mixtures of cancer and normal cells. Thus, the data obtained from these samples are mixed signals. The "tumor purity", or the percentage of cancer cells in cancer tissue sample, will bias the clustering results if not properly accounted for...
May 4, 2017: Bioinformatics
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