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Penis cancer

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https://www.readbyqxmd.com/read/27864120/epidermal-growth-factor-receptor-as-an-adverse-survival-predictor-in-squamous-cell-carcinoma-of-the-penis
#1
Alice Muglia Thomaz da Silva Amancio, Isabela Werneck da Cunha, José Ivanildo Neves, Josiane da Silva Quetz, Dirce Maria Carraro, Rafael Malagoli Rocha, Stenio Cássio Zequi, Antonio Leopoldo Cubilla, Francisco Paulo da Fonseca, Ademar Lopes, Maria do Perpétuo Socorro Saldanha da Cunha, Marcos Venício Alves Lima, José Vassallo, Gustavo Cardoso Guimarães, Fernando Augusto Soares
Penile carcinoma (PC) is more frequent in underdeveloped countries, generally is diagnosed at an advanced stage when therapeutic options are restricted, and thus is associated with high morbidity/mortality rates. Recent studies have demonstrated clinical benefits with epidermal growth factor receptor (EGFR)-targeted therapy in PC patients, although there is no test that provides accurate patient selection. The aim of the present study was to evaluate the prognostic value of EGFR gene and protein status in tumor samples from patients with primary penile squamous cell carcinoma (SCC)...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27862230/penile-compression-clamps-a-model-of-the-internal-mechanical-state-of-penile-soft-tissues
#2
Ayelet Levy, Mandy Fader, Daniel Bader, Amit Gefen
AIMS: Prostate cancer is the most frequently diagnosed male cancer and urinary incontinence represents a major consequence following surgery. Penile compression clamps (PCCs) which externally occlude the urethra may be used to manage the incontinence. Despite potential complication of PCCs, such as deformation-inflicted tissue damage, to date, there are no reported biomechanical criteria for design of PCCs, in terms of quantitative parameters for evaluating the safety-versus-efficacy of existing or future designs...
November 15, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27862129/anogenital-distance-a-biomarker-of-prenatal-androgen-exposure-is-associated-with-prostate-cancer-severity
#3
Ana B Maldonado-Cárceles, Carlos Sánchez-Rodríguez, Eva M Vera-Porras, Julián J Árense-Gonzalo, Julián Oñate-Celdrán, Paula Samper-Mateo, Damián García-Escudero, Marcos Torres-Roca, Francisco Martínez-Díaz, Jaime Mendiola, Alberto M Torres-Cantero
BACKGROUND: Anogenital distance (AGD), the distance from the centre of the anus to the genitals, is a sexually dimorphic phenotype in mammals. Experimental studies have shown that AGD is a biomarker of prenatal androgen exposure during the masculinisation period of development. The aim of this study is to assess the relationship between anogenital distance (AGD), as an indirect marker of prenatal hormonal environment, and prostate cancer (PCa) severity. MATERIALS: We conducted a cross-sectional study with a total of 120 PCa patients with confirmed biopsy of the tumour from April 2007 to July 2015...
November 16, 2016: Prostate
https://www.readbyqxmd.com/read/27846930/-ccafu-french-national-guidelines-2016-2018-on-penile-cancer
#4
P Sèbe, L Ferretti, P-H Savoie, N Morel-Journel, A Fléchon, T Murez, L Rocher, P Camparo, A Méjean, X Durand
INTRODUCTION: The aim of this work is to establish guidelines proposed by the external genital organ group of the CCAFU for the diagnosis, treatment and follow-up of penile cancer. MATERIAL AND METHODS: The multidisciplinary working party studied 2013 guidelines exhaustively reviewed the literature, and evaluated references and their level of proof in order to attribute grades of recommandation. RESULTS: The most common histological type is squamous cell carcinoma...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27822104/the-danish-national-penile-cancer-quality-database
#5
REVIEW
Jakob Kristian Jakobsen, Buket Öztürk, Mette Søgaard
AIM OF DATABASE: The Danish National Penile Cancer Quality database (DaPeCa-data) aims to improve the quality of cancer care and monitor the diagnosis, staging, and treatment of all incident penile cancer cases in Denmark. The aim is to assure referral practice, guideline adherence, and treatment and development of the database in order to enhance research opportunities and increase knowledge and survival outcomes of penile cancer. STUDY POPULATION: The DaPeCa-data registers all patients with newly diagnosed invasive squamous cell carcinoma of the penis in Denmark since June 2011...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27792895/a-case-report-of-a-complete-degloving-injury-of-the-penile-skin
#6
Helena Aineskog, Fredrik Huss
INTRODUCTION: Male genital degloving injuries are unusual and rarely caused by animal bite. Usually patients attend health care immediately if bitten in the genital area. Prophylactic antibiotics is routinely used (Gomes et al., 2000). A penile degloving usually begins just proximal of the coronal line and progress down to the base of the shaft. Deep erectile tissue and the spermatic cord are seldom damaged and the endogenous skin of glans usually survives (Brown and Fryer, 1957; Morey et al...
October 15, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27746062/glansectomy-and-split-thickness-skin-graft-for-penile-cancer
#7
Arie S Parnham, Maarten Albersen, Varun Sahdev, Michelle Christodoulidou, Raj Nigam, Peter Malone, Alex Freeman, Asif Muneer
BACKGROUND: Penile cancer is a rare malignancy that is confined to the glans in up to four out of five cases. Although descriptions of glansectomy exist, there are no contemporary video explanations or large published single centre series. OBJECTIVE: To show the efficacy and safety of glansectomy and split-thickness skin graft (STSG) reconstruction. DESIGN, SETTING, AND PARTICIPANTS: Data were collected retrospectively for patients identified from surgical theatre diaries between February 2005 and January 2016...
October 13, 2016: European Urology
https://www.readbyqxmd.com/read/27743482/the-management-of-non-visualisation-following-dynamic-sentinel-lymph-node-biopsy-for-squamous-cell-carcinoma-of-the-penis
#8
Varun Sahdev, Maarten Albersen, Michelle Christodoulidou, Arie Parnham, Peter Malone, Raj Nigam, Jamshed Bomanji, Asif Muneer
OBJECTIVES: To review the management and clinical outcomes of uni- or bilateral non-visualization of inguinal lymph nodes following dynamic sentinel lymph node biopsy (DSNB) in patients diagnosed with penile cancer and clinically impalpable inguinal lymph nodes (cN0). An additional objective was to develop an algorithm for the management of patients in which non-visualisation occurs. PATIENTS AND METHODS: This is a retrospective observational study over a period of 4 years comprising 166 patients with penile squamous cell carcinoma undergoing DSNB and followed up for a minimum of 6 months...
October 15, 2016: BJU International
https://www.readbyqxmd.com/read/27717430/contemporary-role-of-radiotherapy-in-the-management-of-primary-penile-tumors-and-metastatic-disease
#9
Juanita Crook
Squamous cell cancer of the penis is a radiocurable malignancy all too often managed solely by partial or total penectomy. Effective management of the primary tumor while preserving penile morphology and function is a priority. External radiotherapy and brachytherapy have a role to play in the definitive management of the primary tumor. Surgical nodal staging remains a cornerstone of management because it is the strongest predictor of survival, and inguinal status determines pelvic management. Postoperative radiotherapy of the regional nodes for high-risk pathology is indicated...
November 2016: Urologic Clinics of North America
https://www.readbyqxmd.com/read/27672265/human-papillomavirus-and-gastrointestinal-cancer-a-review
#10
REVIEW
Dania Bucchi, Fabrizio Stracci, Nicola Buonora, Giuseppe Masanotti
Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. Exposure to HPV is very common, and an estimated 65%-100% of sexually active adults are exposed to HPV in their lifetime. The majority of HPV infections are asymptomatic, but there is a 10% chance that individuals will develop a persistent infection and have an increased risk of developing a carcinoma. The International Agency for Research on Cancer has found that the following cancer sites have a strong causal relationship with HPV: cervix uteri, penis, vulva, vagina, anus and oropharynx, including the base of the tongue and the tonsils...
September 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27631245/hiv-and-cancer-registry-linkage-identifies-a-substantial-burden-of-cancers-in-persons-with-hiv-in-india
#11
Sheela V Godbole, Karabi Nandy, Mansi Gauniyal, Pallavi Nalawade, Suvarna Sane, Shravani Koyande, Joy Toyama, Asha Hegde, Phil Virgo, Kishor Bhatia, Ramesh S Paranjape, Arun R Risbud, Sam M Mbulaiteye, Ronald T Mitsuyasu
We utilized computerized record-linkage methods to link HIV and cancer databases with limited unique identifiers in Pune, India, to determine feasibility of linkage and obtain preliminary estimates of cancer risk in persons living with HIV (PLHIV) as compared with the general population.Records of 32,575 PLHIV were linked to 31,754 Pune Cancer Registry records (1996-2008) using a probabilistic-matching algorithm. Cancer risk was estimated by calculating standardized incidence ratios (SIRs) in the early (4-27 months after HIV registration), late (28-60 months), and overall (4-60 months) incidence periods...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27630937/penile-sarcoma-report-of-a-rare-malignancy
#12
Shiv Rajan, Vijay Kumar, Arun Chaturvedi, Jeevan Ram Vishnoi, Prashant Dontula
Penile cancer is an uncommon malignancy. Squamous cell carcinoma constitutes approximately 95% of all histology. Non-squamous malignancies are rare in penis. Sarcomas of penis are rarer among them. Spindle cell sarcoma is one of the extremely rare sarcoma of penis. To best of our knowledge, only two cases have been reported so far, one in English literature and other in Japanese. We are presenting this uncommon case of spindle cell sarcoma of penis, which was diagnosed with microscopy with its characteristic immunohistochemistry...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27628800/re-development-and-external-validation-of-a-prognostic-tool-for-prediction-of-cancer-specific-mortality-after-complete-loco-regional-pathological-staging-for-squamous-cell-carcinoma-of-the-penis
#13
https://www.readbyqxmd.com/read/27628265/prospective-study-comparing-video-endoscopic-radical-inguinal-lymph-node-dissection-veilnd-with-open-radical-ilnd-oilnd-for-penile-cancer-over-an-8-year-period
#14
Vivekanandan Kumar, K Krishna Sethia
OBJECTIVE: To compare the complications and oncological outcomes between video-endoscopic inguinal lymph node dissection (VEILND) and open ILND (OILND) in men with carcinoma of the penis. PATIENTS AND METHODS: A prospectively collected institutional database was used to determine the outcomes in 42 consecutive patients undergoing ILND between 2008 and 2015 in a centre for treating penile cancer. Before 2013 all procedures were OILNDs. Since 2013 we have performed VEILND on all patients in need of ILND...
September 15, 2016: BJU International
https://www.readbyqxmd.com/read/27600594/searching-beyond-the-usual-papillomavirus-suspects-in-squamous-carcinomas-of-the-vulva-penis-and-head-and-neck
#15
Marta Félez-Sánchez, Marleny Vergara, Silvia de Sanjosé, Xavier Castellsagué, Laia Alemany, Ignacio G Bravo
Human Papillomaviruses (HPVs) are involved in the etiology of anogenital and head and neck cancers. The HPV DNA prevalence greatly differs by anatomical site. Indeed, the high rates of viral DNA prevalence in anal and cervical carcinomas contrast with the lower fraction of cancer cases attributable to HPVs in other anatomical sites, chiefly the vulva, the penis and head and neck. Here we analyzed 2635 Formalin Fixed Paraffin Embedded surgical samples that had previously tested negative for the presence of HPVs DNA using the SPF10/DEIA procedure, in order to identify the presence of other PVs not explicitly targeted by standard molecular epidemiologic approaches...
September 4, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27594553/pathologic-evaluation-and-reporting-of-carcinoma-of-the-penis
#16
Andreas Erbersdobler
Carcinoma of the penis is a rare tumor in the United States and in western European countries. Clinical management has become more complex in recent years, because organ-preserving strategies are being favored. Furthermore, our understanding of the pathogenesis of this malignancy has grown considerably. As a result of these developments, the demands on the pathology reports of surgical specimens from the penis have increased. There are also some peculiarities with the current World Health Organization and TNM classification systems of penile cancer as compared with other tumor entities...
August 10, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27552138/the-role-of-surgery-in-metastatic-squamous-cell-carcinoma-of-the-penis
#17
Nicola Nicolai, Mario Catanzaro, Michele Zazzara
PURPOSE OF REVIEW: Prognosis of penile squamous cell cancer (PeSCC) depends on the involvement of the groin(s) as first step. We introduce the current available evidences that should rule the use of surgery in the management of PeSCC. RECENT FINDINGS: Prophylactic inguinal node dissection in patients with no palpable nodes associates with immediate and long-term side-effects in up to 70% of patients. Recent findings support selective intervention based on early identification of dynamic sentinel node biopsy (DSNB) with false negative rate of 4-12%...
November 2016: Current Opinion in Urology
https://www.readbyqxmd.com/read/27551559/quality-of-life-in-penile-carcinoma-patients-post-total-penectomy
#18
Roman Sosnowski, Marta Kulpa, Mariola Kosowicz, Jan Karol Wolski, Olga Kuczkiewicz, Katarzyna Moskal, Michał Szymański, Tomasz Kalinowski, Tomasz Demkow
INTRODUCTION: Total amputation, as a treatment for advanced penile cancer, significantly debilitates the patient's quality of life and sexual function. The aim of the study was to assess the quality of life in patients who had undergone total penectomy. MATERIAL AND METHODS: The questionnaires EORTC QLQ C-30, SES, CMNI, and a modified IIEF-15 questionnaire, were sent to 11 patients. RESULTS: A total of 10 patients returned the questionnaires completed...
2016: Central European Journal of Urology
https://www.readbyqxmd.com/read/27523740/immunogenicity-of-next-generation-hpv-vaccines-in-non-human-primates-measles-vectored-hpv-vaccine-versus-pichia-pastoris-recombinant-protein-vaccine
#19
Gaurav Gupta, Viviana Giannino, Narayan Rishi, Reinhard Glueck
Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide. HPVs are oncogenic small double-stranded DNA viruses that are the primary causal agent of cervical cancer and other types of cancers, including in the anus, oropharynx, vagina, vulva, and penis. Prophylactic vaccination against HPV is an attractive strategy for preventing cervical cancer and some other types of cancers. However, there are few safe and effective vaccines against HPV infections. Current first-generation commercial HPV vaccines are expensive to produce and deliver...
September 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27522713/-melanoma-and-human-papillomaviruses-is-there-an-outlook-for-study
#20
REVIEW
G M Volgareva, I N Mikhaylova, D A Golovina
Melanoma is one of the most aggressive human malignant tumors. Its incidence and mortality are growing steadily. Ultraviolet irradiation is the main risk factor for melanoma involved in melanomagenesis. The probability of viral etiology of melanoma has been discussed. Human papillomaviruses (HPV) have been mentioned among candidates for its etiologic agents because some HPV types are the powerful carcinogens causing cervical cancer and other cancers. The review analyses the literature data on the association of melanoma with HPV Several groupsfound HPVin skin melanomas as well as in mucosa; viruses of high oncogenic risk were detected in some cases...
2016: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
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