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https://www.readbyqxmd.com/read/28088767/pharmacokinetic-study-of-anidulafungin-in-icu-patients-with-intra-abdominal-candidiasis
#1
H Dupont, L Massias, B Jung, N Ammenouche, P Montravers
BACKGROUND: Only limited pharmacokinetic data are available for anidulafungin in ICU patients, especially in patients treated for severe intra-abdominal infection (IAI). METHODS: This was a prospective multicentre observational study in ICU patients with suspected yeast IAI. All patients received an intravenous loading dose of 200 mg of anidulafungin, followed by 100 mg/day. Thirteen blood samples were drawn between day 1 and day 5 for pharmacokinetic analysis...
January 14, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28076898/characterization-of-the-hog1-mapk-pathway-in-the-entomopathogenic-fungus-beauveria-bassiana
#2
Jing Liu, Zhi-Kang Wang, Huan-Huan Sun, Sheng-Hua Ying, Ming-Guang Feng
High-osmolarity glycerol (HOG) pathway required for yeast osmoregulation relies upon the mitogen-activated protein kinase (MAPK) Hog1 cascade that comprise the MAPKKKs Ssk2/Ssk22 and Ste11 converging on the MAPKK Pbs2. Here we show a Hog1 cascade with the unique MAPKKK Ssk2 acting in Beauveria bassiana. Hypersensitivity to high osmolarity and high resistance to fludioxonil fungicide appeared in Δssk2, Δpbs2 and Δhog1 mutants whereas the two hallmark phenotypes were reversed in Δste11. Increased sensitivity to heat shock and decreased sensitivity to cell wall perturbation also occurred in the three mutants but not in Δste11 although antioxidant phenotypes were different in all deletion mutants...
January 11, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28071648/foliar-application-of-the-leaf-colonizing-yeast-pseudozyma-churashimaensis-elicits-systemic-defense-of-pepper-against-bacterial-and-viral-pathogens
#3
Gahyung Lee, Sang-Heon Lee, Kyung Mo Kim, Choong-Min Ryu
Yeast associates with many plant parts including the phyllosphere, where it is subject to harsh environmental conditions. Few studies have reported on biological control of foliar pathogens by yeast. Here, we newly isolated leaf-colonizing yeasts from leaves of field-grown pepper plants in a major pepper production area of South Korea. The yeast was isolated using semi-selective medium supplemented with rifampicin to inhibit bacterial growth and its disease control capacity against Xanthomonas axonopodis infection of pepper plants in the greenhouse was evaluated...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28067229/tubules-of-plant-reoviruses-exploit-tropomodulin-to-regulate-actin-based-tubule-motility-in-insect-vector
#4
Qian Chen, Linghua Zhang, Yanshuang Zhang, Qianzhuo Mao, Taiyun Wei
Plant reoviruses are known to exploit virion-packaging tubules formed by virus-encoding non-structural proteins for viral spread in insect vectors. Tubules are propelled by actin-based tubule motility (ABTM) to overcome membrane or tissue barriers in insect vectors. To further understand which insect factors mediate ABTM, we utilized yeast two-hybrid and bimolecular fluorescence complementation assays to test interactions between tubule protein Pns10 of rice dwarf virus (RDV), a plant reovirus, and proteins of its insect vector, the leafhopper Nephotettix cincticeps...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28066814/species-in-the-cryptococcus-gattii-complex-differ-in-capsule-and-cell-size-following-growth-under-capsule-inducing-conditions
#5
Kenya E Fernandes, Christine Dwyer, Leona T Campbell, Dee A Carter
Cryptococcus gattii causes invasive fungal infections that have been increasing in incidence and global distribution in recent years. The major molecular genotypes of C. gattii that were previously classified as VGI to VGIV have recently been described as four new species: C. gattii (VGI), C. deuterogattii (VGII), C. bacillisporus (VGIII), and C. tetragattii (VGIV). The main driver for their classification has been phylogeny, and phenotypic diversity has not yet been extensively characterized. This study examines variation in attributes related to virulence and pathogenicity, including capsule thickness, cell size, tolerance to temperature, oxidative and osmotic stress, and cell wall integrity...
November 2016: MSphere
https://www.readbyqxmd.com/read/28063982/proteomic-analysis-of-lysine-succinylation-of-the-human-pathogen-histoplasma-capsulatum
#6
Longxiang Xie, Juan Li, Wanyan Deng, Zhaoxiao Yu, Wenjie Fang, Min Chen, Wanqing Liao, Jianping Xie, Weihua Pan
: Histoplasma capsulatum, the causative agent of histoplasmosis (also called "Darling's disease"), can affect both immunocompetent and immunocompromised hosts. Post-translational protein modification by lysine succinylation (Ksuc) is a frequent occurrence in eukaryote and prokaryote. Recently, the roles of succinylation and its regulatory enzymes in regulating metabolic pathway in bacteria, mammalian and fungus were highlighted. Here, we report the first global profiling of lysine succinylation, with 463 modification sites in 202 proteins from H...
January 4, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28063567/vulvovaginite-d%C3%A3-pistage-et-prise-en-charge-de-la-trichomonase-de-la-candidose-vulvovaginale-et-de-la-vaginose-bact%C3%A3-rienne
#7
Julie van Schalkwyk, Mark H Yudin
OBJECTIF: Analyser les données probantes et formuler des recommandations quant au dépistage et à la prise en charge de la candidose vulvovaginale, de la trichomonase et de la vaginose bactérienne. ISSUES: Parmi les issues évaluées, on trouve l'efficacité de l'antibiothérapie, les taux de guérison en ce qui concerne les infections simples et compliquées, et les implications de ces pathologies pendant la grossesse. RéSULTATS: La littérature publiée a été récupérée par l'intermédiaire de recherches menées dans MEDLINE, EMBASE, CINAHL et The Cochrane Library en juin 2013 au moyen d'un vocabulaire contrôlé (p...
December 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28062578/gmp-synthase-is-required-for-virulence-factor-production-and-infection-by-cryptococcus-neoformans
#8
Jessica L Chitty, Tayla L Tatzenko, Simon J Williams, Y Q Andre E Koh, Elizabeth C Corfield, Mark S Butler, Avril A B Robertson, Matthew A Cooper, Ulrike Kappler, Bostjan Kobe, James A Fraser
Over the last four decades the HIV pandemic and advances in medical treatments that also cause immunosuppression have produced an ever-growing cohort of individuals susceptible to opportunistic pathogens. Of these, AIDS patients are particularly vulnerable to infection by the encapsulated yeast Cryptococcus neoformans Most commonly found in the environment in purine-rich bird guano, C. neoformans experiences a drastic change in nutrient availability during host infection, ultimately disseminating to colonize the purine-poor central nervous system...
January 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28053145/study-of-differential-expression-of-mirnas-in-lung-tissue-of-mice-submitted-to-experimental-infection-by-paracoccidioides-brasiliensis
#9
Denise Turini Gonzales Marioto, Ana Carolina Navarro Dos Santos Ferraro, Fábio Goulart de Andrade, Marília Barros Oliveira, Eiko Nakagawa Itano, Silvana Petrofeza, Emerson José Venancio
MicroRNAs (miRNAs) are small single stranded RNA sequences involved in post-transcriptional regulation of different biological and physiological processes. Paracoccidioidomycosis (PCM) is an infection caused by Paracoccidioides brasiliensis, and it is a major cause of mortality due to systemic mycoses in Brazil. To date, there have been few reports on the role of miRNAs in the immune response against fungi, especially PCM. The objective of this study was to evaluate the differential expression of miRNAs related to the inflammatory response associated with pulmonary infection by P...
January 3, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28052349/chemical-composition-and-antifungal-activity-of-carica-papaya-linn-seeds-essential-oil-against-candida-spp
#10
Xiaowen He, Yinzheng Ma, Guohui Yi, Jinyan Wu, Limin Zhou, Hong Guo
In recent years, the incidence of clinical yeast infections has increased dramatically. Due to the extensive use of broad-spectrum antifungal agents, there has been a notable increase in drug resistance among infections yeast species. As one of the most popular natural antimicrobial agents, essential oils (EOs) have attracted a lot of attention from the scientific community. The aim of this study was to analyze the chemical composition and examine the antifungal activity of the EO extracted from the seeds of Carica papaya Linn...
January 4, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28049510/identification-of-host-proteins-interacting-with-toxoplasma-gondii-gra15-tggra15-by-yeast-two-hybrid-system
#11
Qing Liu, Fa-Cai Li, Hany M Elsheikha, Miao-Miao Sun, Xing-Quan Zhu
BACKGROUND: Toxoplasma gondii, an obligate intracellular protozoan parasite, possesses the remarkable ability to co-opt host cell machinery in order to maintain its intracellular survival. This parasite can modulate signaling pathways of its host through the secretion of polymorphic effector proteins localized in the rhoptry and dense granule organelles. One of such effectors is T. gondii type II-specific dense granule protein 15, TgGRA15, which activates NF-κB pathway. The aim of the present study was to identify the host interaction partner proteins of TgGRA15...
January 3, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28043787/-clusters-of-fusarium-solani-infection-in-juvenile-captive-born-caretta-caretta-sea-turtles
#12
M Garcia-Hartmann, C Hennequin, S Catteau, C Béatini, V Blanc
Various yeasts and filamentous fungi are described as the cause of infection in sea turtles. Among them, Fusarium solani is responsible both for superficial and invasive infection in weakened adults (capture, stranding), and wild nest contamination, causing massive losses during hatching. We illustrate the pathogenicity of this fungus in sea turtles, through our experience with the species Caretta caretta (loggerhead turtle) and its reproduction, which was obtained for the first time in 2010 at the marine park Marineland, Antibes and renewed in 2011 and 2013...
December 30, 2016: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28043539/invasive-forms-of-candida-and-aspergillus-in-sputum-samples-of-pulmonary-tuberculosis-patients-attending-the-tuberculosis-reference-laboratory-in-ghaemshahr-northern-iran-an-analysis-of-samples-collected-during-the-past-10years
#13
Mohammad Reza Jabbari Amiri, Seyed Reza Aghili, Tahereh Shokohi, Mohammad Taghi Hedayati, Mahdi Abastabar, Masoud Aliyali, Masoumeh Jabbari Amiri, Hamid Hasanpour
OBJECTIVE/BACKGROUND: Tuberculosis (TB) continues to be a major public health problem worldwide. This is especially true in Northern Iran, which has high TB prevalence. The chronic nature of this disease is further exacerbated if it is accompanied by fungal infection, which usually remains undiagnosed and thus untreated. Thus, mycotic infections add fatal dimensions to pulmonary TB. Our objective was to determine the prevalence of invasive forms of fungal elements in sputum samples collected from patients with pulmonary TB at a reference laboratory in Ghaemshahr, Northern Iran, during the past 10years...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28041812/metabolic-adaptation-via-regulated-enzyme-degradation-in-the-pathogenic-yeast-candida-albicans
#14
S Y Ting, O A Ishola, M A Ahmed, Y M Tabana, S Dahham, M T Agha, S F Musa, R Muhammed, L T L Than, D Sandai
The virulence of Candida albicans is dependent upon fitness attributes as well as virulence factors. These attributes include robust stress responses and metabolic flexibility. The assimilation of carbon sources is important for growth and essential for the establishment of infections by C. albicans. Previous studies showed that the C. albicans ICL1 genes, which encode the glyoxylate cycle enzymes isocitratelyase are required for growth on non-fermentable carbon sources such as lactate and oleic acid and were repressed by 2% glucose...
December 29, 2016: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28040170/hanseniaspora-uvarum-prolongs-shelf-life-of-strawberry-via-volatile-production
#15
Xiaojie Qin, Hongmei Xiao, Xu Cheng, Hailian Zhou, Linyuan Si
Gray mold caused by Botrytis cinerea led to severe postharvest losses for strawberry industry. In recent years, some studies have shown that postharvest diseases of strawberry can be controlled by using bacterial, fungal and yeast strains. The yeast strain Hanseniaspora uvarum was shown as an effective antagonist against B. cinerea growth. Here, we further investigated the volatile organic compounds (VOCs) production of H. uvarum and how this could impact on postharvest gray mold control of strawberry. A total of 28 VOCs were detected by GC-MS in the headspace of H...
May 2017: Food Microbiology
https://www.readbyqxmd.com/read/28040168/performance-evaluation-of-volatile-organic-compounds-by-antagonistic-yeasts-immobilized-on-hydrogel-spheres-against-gray-green-and-blue-postharvest-decays
#16
Lucia Parafati, Alessandro Vitale, Cristina Restuccia, Gabriella Cirvilleri
Wickerhamomyces anomalus, Metschnikowia pulcherrima, Aureobasidium pullulans and Saccharomyces cerevisiae yeasts were tested for their ability to survive and synthesize antifungal volatile organic compounds (VOCs) both in vitro and in vivo conditions when immobilized on commercial hydrogel spheres. The results showed a good survival of all yeasts on hydrogel spheres up to 10 days of incubation. Moreover, VOCs produced in vitro by tested yeasts inhibited Botrytis cinerea, Penicillium digitatum and P. italicum radial growth and conidial germination, with the highest antagonistic activity reported for W...
May 2017: Food Microbiology
https://www.readbyqxmd.com/read/28034779/a-mitochondrial-membrane-protein-is-a-target-for-rice-ragged-stunt-virus-in-its-insect-vector
#17
Hai-Jian Huang, Cheng-Wen Liu, Xiang Zhou, Chuan-Xi Zhang, Yan-Yuan Bao
Rice ragged stunt virus (RRSV; Reoviridae) is exclusively transmitted by the brown planthopper Nilaparvata lugens in a persistent-propagative manner. It is understood that RNA viral proliferation is associated with the intracellular membranes of the insect host cells. However, the molecular mechanisms of the interaction between the RRSV proliferation and the intracellular membranes remain essentially unknown. It will be of great interest to determine whether RRSV protein(s) directly interact with intracellular membrane components of its host cells...
February 2, 2017: Virus Research
https://www.readbyqxmd.com/read/28027291/interaction-of-prions-causes-heritable-traits-in-saccharomyces-cerevisiae
#18
Anton A Nizhnikov, Tatyana A Ryzhova, Kirill V Volkov, Sergey P Zadorsky, Julia V Sopova, Sergey G Inge-Vechtomov, Alexey P Galkin
The concept of "protein-based inheritance" defines prions as epigenetic determinants that cause several heritable traits in eukaryotic microorganisms, such as Saccharomyces cerevisiae and Podospora anserina. Previously, we discovered a non-chromosomal factor, [NSI+], which possesses the main features of yeast prions, including cytoplasmic infectivity, reversible curability, dominance, and non-Mendelian inheritance in meiosis. This factor causes omnipotent suppression of nonsense mutations in strains of S. cerevisiae bearing a deleted or modified Sup35 N-terminal domain...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/28025839/biological-and-structural-effects-of-the-conjugation-of-an-antimicrobial-decapeptide-with-saturated-unsaturated-methoxylated-and-branched-fatty-acids
#19
María Verónica Húmpola, María Carolina Rey, Nestor M Carballeira, Arturo Carlos Simonetta, Georgina Guadalupe Tonarelli
The increasing bacterial resistance against conventional antibiotics has led to the search for new antimicrobial drugs with different modes of action. Cationic antimicrobial peptides (AMPs) and lipopeptides are promising candidates to treat infections because they act on bacterial membranes causing rapid destruction of sensitive bacteria. In this study, a decapeptide named A2 (IKQVKKLFKK) was conjugated at the N-terminus with saturated, unsaturated, methoxylated and methyl -branched fatty acids of different chain lengths (C8 - C20), the antimicrobial and structural properties of the lipopeptides being then investigated...
December 26, 2016: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28024866/saccharomyces-boulardii-probiotic-associated-fungemia-questioning-the-safety-of-this-preventive-probiotic-s-use
#20
Isabella W Martin, Rita Tonner, Julie Trivedi, Heather Miller, Richard Lee, Xinglun Liang, Leo Rotello, Elena Isenbergh, Jennifer Anderson, Trish Perl, Sean X Zhang
We report a case of fungemia in an immunocompetent patient after administration of probiotic containing Saccharomyces boulardii. We demonstrated the strain relatedness of the yeast from the probiotic capsule and the yeast causing fungal infection using genomic and proteomic typing methods. Our study questions the safety of this preventative biotherapy.
December 16, 2016: Diagnostic Microbiology and Infectious Disease
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