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https://www.readbyqxmd.com/read/27882249/surviving-all-odds-a-unique-case-of-multiple-congenital-unruptured-sinus-of-valsalva-aneurysms-involving-both-left-and-right-coronary-sinuses-with-biventricular-dysfunction-and-heart-block
#1
Aniketh Vijay B, Vikrant Vijan, Navin Mathew
Aneurysms of the sinus of Valsalva are very uncommon, with an incidence ranging from 0.1 to 3.5% of all congenital heart defects. Very few cases have been reported in the literature that presented with involvement of two or more sinuses. We report a case of 27-year-old male with a history of exertional breathlessness of one-month duration. After complete evaluation using transesophageal echocardiography (TEE) and multiple detector computed tomography (MDCT) scanning, the patient was diagnosed to have large congenital unruptured sinus of Valsalva aneurysms involving both left and right coronary sinuses with extension into the interventricular septum...
2016: Case Reports in Cardiology
https://www.readbyqxmd.com/read/27849189/sleep-related-bradyarrhythmic-events-and-heart-rate-variability-in-apparently-healthy-individuals
#2
Tolga Çimen, Hamza Sunman, Mehmet Erat, Tolga Han Efe, Ahmet Akyel, Murat Bilgin, Sadık Açıkel, Mehmet Doğan, Ekrem Yeter
OBJECTIVE: It is thought that abnormal cardiac impulses of the autonomic nervous system during sleep are responsible for sleep-related bradyarrhythmias. Despite a proposed common etiopathogenesis and having common name of "sleep-related bradyarrhythmias," precise importance of sinoatrial or atrioventricular (AV) node involvement remains elusive. This study aimed to determine whether there is a difference in sleeprelated bradyarrhythmias from the point of view of heart rate variability (HRV)...
November 10, 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27717423/conduction-disorders-after-sutureless-aortic-valve-replacement
#3
Ismail Bouhout, Amine Mazine, Lena Rivard, Aly Ghoneim, Ismail El-Hamamsy, Yoan Lamarche, Michel Carrier, Philippe Demers, Denis Bouchard
BACKGROUND: Sutureless self-expandable aortic bioprostheses rely on radial forces for stabilization, raising concern that these devices may increase the risk of postoperative conduction disease. The purpose of this study was to determine the incidence of conduction disorders after sutureless aortic valve replacement (AVR) with the Perceval S (Sorin Group, Saluggia, Italy) bioprosthesis. METHODS: Between June 2011 and March 2013, 108 consecutive patients underwent sutureless AVR with the Perceval S prosthesis...
October 4, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27695244/cardiac-arrhythmia-in-wilson-s-disease-an-oversighted-and-overlooked-entity
#4
Bhupender Kumar Bajaj, Ankur Wadhwa, Richa Singh, Saurabh Gupta
Wilson's disease is a multisystem disorder which manifests with hepatic, neurological, musculoskeletal, hematological, renal, and cardiac symptoms. The hepatic and neurological manifestations often overshadow the other system involvement including cardiac symptoms and signs, which may prove fatal. We report a case of a young female who presented with progressive parkinsonian features and dystonia for around 4 months followed 2 months later by the complaint of episodes of light-headedness. She was diagnosed to have Wilson's disease based on the presence of Kayser-Fleischer ring and laboratory parameters of copper metabolism...
October 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/27624575/cardiac-safety-profile-of-first-dose-of-fingolimod-for-relapsing-remitting-multiple-sclerosis-in-real-world-settings-data-from-a-german-prospective-multi-center-observational-study
#5
Ralf A Linker, Guillaume Wendt
INTRODUCTION: Fingolimod was the first oral therapy approved for the treatment of relapsing-remitting multiple sclerosis (RRMS). Due to its action on cardiac sphingosine 1-phosphate receptors, fingolimod is leading to a transient decrease in heart rate (HR) and the occurrence of rare and asymptomatic self-limited atrioventricular (AV) blocks. This German non-interventional clinical study aimed to assess the cardiac safety profile in RRMS patients during at least 6 h after the initial treatment or restart after interruption of fingolimod in real-world settings...
December 2016: Neurology and Therapy
https://www.readbyqxmd.com/read/27563395/discovery-of-novel-dot1l-inhibitors-through-a-structure-based-fragmentation-approach
#6
Chao Chen, Hugh Zhu, Frédéric Stauffer, Giorgio Caravatti, Susanne Vollmer, Rainer Machauer, Philipp Holzer, Henrik Möbitz, Clemens Scheufler, Martin Klumpp, Ralph Tiedt, Kim S Beyer, Keith Calkins, Daniel Guthy, Michael Kiffe, Jeff Zhang, Christoph Gaul
Oncogenic MLL fusion proteins aberrantly recruit Dot1L, a histone methyltransferase, to ectopic loci, leading to local hypermethylation of H3K79 and misexpression of HoxA genes driving MLL-rearranged leukemias. Inhibition of the methyltransferase activity of Dot1L in this setting is predicted to reverse aberrant H3K79 methylation, leading to repression of leukemogenic genes and tumor growth inhibition. In the context of our Dot1L drug discovery program, high-throughput screening led to the identification of 2, a weak Dot1L inhibitor with an unprecedented, induced pocket binding mode...
August 11, 2016: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27563394/optimization-of-a-fragment-based-screening-hit-toward-potent-dot1l-inhibitors-interacting-in-an-induced-binding-pocket
#7
Clemens Scheufler, Henrik Möbitz, Christoph Gaul, Christian Ragot, Céline Be, César Fernández, Kim S Beyer, Ralph Tiedt, Frédéric Stauffer
Mixed lineage leukemia (MLL) gene rearrangement induces leukemic transformation by ectopic recruitment of disruptor of telomeric silencing 1-like protein (DOT1L), a lysine histone methyltransferase, leading to local hypermethylation of H3K79 and misexpression of genes (including HoxA), which drive the leukemic phenotype. A weak fragment-based screening hit identified by SPR was cocrystallized with DOT1L and optimized using structure-based ligand optimization to yield compound 8 (IC50 = 14 nM). This series of inhibitors is structurally not related to cofactor SAM and is not interacting within the SAM binding pocket but induces a pocket adjacent to the SAM binding site...
August 11, 2016: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27542789/transfemoral-aortic-valve-implantation-with-the-repositionable-lotus-valve-for-treatment-of-patients-with-symptomatic-severe-aortic-stenosis-results-from-a-single-centre-experience
#8
Jochen Wöhrle, Birgid Gonska, Christoph Rodewald, Julia Seeger, Dominik Scharnbeck, Wolfgang Rottbauer
AIMS: The aim of the study was to evaluate the procedural and 30-day results for the repositionable Lotus valve in patients undergoing transfemoral aortic valve implantation in a single-centre experience. METHODS AND RESULTS: We prospectively enrolled 110 patients with severe symptomatic aortic stenosis (NCT02162069). All procedures were performed without general anaesthesia by the transfemoral approach. Patients were followed for 30 days. Patients received the 23 mm (n=20), 25 mm (n=43) or 27 mm (n=47) Lotus device...
August 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27449107/expanding-the-opportunities-for-modulating-kinase-targets-with-allosteric-approaches
#9
Henrik Möbitz, Wolfgang Jahnke, Sandra W Cowan-Jacob
The need for novel approaches for targeting well-known protein families in drug discovery has been discussed for several years. There is a huge amount of literature on the inhibition of kinases with small molecules targeting the ATP site, and as a result of this extensive research, there are a large number of kinase inhibitors in the clinic. However, even though the idea of targeting other sites on kinases is not new, relatively little has been reported. In this review we give an overview of structurally characterized allosteric kinase inhibitors, outline the benefits of these with the use of case studies and then discuss the challenges that need to be overcome and the opportunities for doing this...
July 19, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27448652/expanding-the-opportunities-for-modulating-kinase-targets-with-allosteric-approaches
#10
Henrik Möbitz, Wolfgang Jahnke, Sandra W Cowan-Jacob
The need for novel approaches for targeting well-known protein families in drug discovery has been discussed for several years. There is a huge amount of literature on the inhibition of kinases with small molecules targeting the ATP site, and as a result of this extensive research, there are a large number of kinase inhibitors in the clinic. However, even though the idea of targeting other sites on kinases is not new, relatively little has been reported. In this review we give an overview of structurally characterized allosteric kinase inhibitors, outline the benefits of these with the use of case studies and then discuss the challenges that need to be overcome and the opportunities for doing this...
July 19, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27225279/mobitz-type-i-and-ii-atrioventricular-blocks-during-fingolimod-therapy
#11
Francesco Saccà, Giorgia Puorro, Angela Marsili, Chiara Pane, Cinzia Valeria Russo, Roberta Lanzillo, Anna de Rosa, Antonio Cittadini, Giuseppe De Angelis, Vincenzo Brescia Morra
We investigated patients who showed a second-degree atrioventricular block (S-AVB) after the first fingolimod administration. We observed six patients with S-AVB, three Mobitz type I, and three type II. Monitoring continued on the second day for all patients. Three patients showed persistence of the S-AVB, with resolution on the second or third day. One patient had a persistent S-AVB up to the fourth day when fingolimod was discontinued. We conclude that Mobitz type II S-AVB is possible during fingolimod therapy...
September 2016: Neurological Sciences
https://www.readbyqxmd.com/read/26964391/failure-of-intravenous-lipid-emulsion-in-treatment-of-cardiotoxicity-caused-by-mixed-overdose-including-dihydropyridine-calcium-channel-blockers
#12
Jasmina Jović-Stosić, Vesna Putić, Dragan Zivanović, Milica Mladenov, Gordana Brajković, Snelana Djordjević
INTRODUCTION: Calcium channel blockers and beta-blockers are among the most frequently ingested cardiovascular drugs in self-poisoning causing significant mortality. Intravenous lipid emulsion (ILE) is reported as a potentially novel antidote for treatment of acute poisoning caused by some of these drugs. CASE REPORT: We presented two cases of poisoning with these drugs. The case 1, a 24-year-old woman ingested amplodipine, metformin and gliclazide for self-poisoning...
January 2016: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/26920166/diagnostic-and-prognostic-implications-of-surface-recordings-from-patients-with-atrioventricular-block
#13
REVIEW
William P Nelson
The atrioventricular (AV) bridge is vulnerable to many circumstances that depress conduction. Abnormal impulse transmission may be caused by drugs, autonomic effects, or destructive processes. Type 1 (Wenckebach) AV block is owing to depressed AV nodal conduction and is recognized by a prolonging PR interval ending in a "dropped beat." Type II (Mobitz) AV block is owing to abnormal infranodal conduction, and is usually accompanied by bundle branch block. Second-degree AV block with 2:1 conduction can be a difficult problem...
March 2016: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/26883019/incidence-and-timing-of-potentially-high-risk-arrhythmias-detected-through-long-term-continuous-ambulatory-electrocardiographic-monitoring
#14
Matthew D Solomon, Jingrong Yang, Sue Hee Sung, Martha L Livingston, George Sarlas, Judith C Lenane, Alan S Go
BACKGROUND: Ambulatory electrocardiographic (ECG) monitoring is the standard to screen for high-risk arrhythmias. We evaluated the clinical utility of a novel, leadless electrode, single-patient-use ECG monitor that stores up to 14 days of a continuous recording to measure the burden and timing of potentially high-risk arrhythmias. METHODS: We examined data from 122,815 long term continuous ambulatory monitors (iRhythm ZIO® Service, San Francisco) prescribed from 2011 to 2013 and categorized potentially high-risk arrhythmias into two types: (1) ventricular arrhythmias including non-sustained and sustained ventricular tachycardia and (2) bradyarrhythmias including sinus pauses >3 s, atrial fibrillation pauses >5 s, and high-grade heart block (Mobitz Type II or third-degree heart block)...
2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/26851815/syncope-in-patients-paced-for-atrioventricular-block
#15
Milena Aste, Daniele Oddone, Paolo Donateo, Alberto Solano, Roberto Maggi, Francesco Croci, Diana Solari, Michele Brignole
AIMS: Although syncope is the main reason for cardiac pacing in ∼40% of patients affected by atrioventricular block (AVB), very few data are available on the benefit of cardiac pacing in preventing syncopal recurrences. METHODS AND RESULTS: We retrospectively evaluated 229 consecutive patients (124 males, age 80 ± 10 years) who had received a permanent pacemaker from January 2009 to December 2013 for AVB and syncope (94 patients, 41%) or AVB without syncope (135 patients, 59%)...
February 6, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/26850221/atrioventricular-conduction-disturbances-immediately-after-hepatic-graft-reperfusion-and-their-outcomes-in-patients-undergoing-liver-transplantation
#16
Sung-Hoon Kim, Young-Jin Moon, Sooho Lee, Sung-Moon Jeong, Jun-Gol Song, Gyu-Sam Hwang
Hemodynamic perturbation during hepatic graft reperfusion in patients undergoing liver transplantation (LT) is challenging and is frequently accompanied by bradyarrhythmia and even asystole. However, detailed data on electrocardiographic (ECG) changes during reperfusion are almost nonexistent, although the correct diagnosis by record is important for the treatment. We aimed to identify ECG rhythm disturbances during graft reperfusion and to investigate risk factors and outcomes. Data from 1065 consecutive patients who underwent adult LT were analyzed...
July 2016: Liver Transplantation
https://www.readbyqxmd.com/read/26737292/formation-of-second-degree-atrioventricular-blocks-in-the-cardiac-heterogeneous-oscillator-model
#17
Elena Ryzhii, Maxim Ryzhii
We study formation of second-degree atrioventricular blocks (Wenckebach and Mobitz types) with reduction of coupling between nodes in the heterogeneous oscillator model of cardiac conduction system. We demonstrate that maximal possible number of physiological mode lock patterns in both cases appears at a particular value of coupling coefficient. For the type II atrioventricular block total conduction ratio at high sinus rates might be represented by a product of conduction ratios of atrioventricular nodal and infrahisian blocks...
August 2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/26689859/long-term-effects-of-frequent-maximal-breath-holding-on-the-cardiac-health-of-elite-freedivers
#18
I Zelenkova, P Chomahidze
Cardiac arrhythmias are commonly reported in freedivers during maximal voluntary breath-holds, but their influence on the cardiological status and their long-term effects on the cardiac health of these athletes have not been investigated. Here we present the results of a study on 32 healthy young men (mean age 32.6 ± 1.3 years) who were divided into two groups of 16 subjects. One group included 16 continuously training freedivers at the "high achievers in sports" level (DIVERS group). The CONTROL group included 16 healthy young men not involved in sports...
December 22, 2015: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/26653699/tricuspid-valve-endocarditis-complicated-by-mobitz-type-ii-heart-block-a-case-report-and-literature-review
#19
Chidozie Charles Agu, Divya Salhan, Ahmed Bakhit, Hiba Basheer, Md Basunia, Bikash Bhattarai, Vikram Oke, Marie Frances Schmidt, Alix Dufresne
We present a case of a middle-aged male who manifested with low-grade fever and lower back pain. MRI and bone scan of the spine were suggestive of vertebral osteomyelitis. Blood cultures were persistently positive for Enterococcus faecalis and echocardiogram revealed tricuspid valve endocarditis. There was no history of IV drug use and urine toxicology was negative. EKG showed Mobitz type II AV block and a transesophageal echocardiogram revealed no valve ring or septal abscesses. The heart block persisted despite antibiotic therapy and an epicardial pacemaker was placed...
2015: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/26536992/a-case-of-mobitz-type-ii-atrioventricular-block-due-to-nerium-oleander-poisoning-successfully-managed-with-digoxin-specific-fab-antibody-fragments
#20
Mustafa Adem Tatlısu, Elif İjlal Çekirdekçi, Şükrü Akyüz, Zekeriya Nurkalem
Nerium oleander is a popular ornamental plant grown in many tropical and subtropical countries and in the Mediterranean region. It is dangerous because it has been shown to contain several types of cardiac glycosides, and hence can cause cardiac arrhythmias resembling digoxin in their toxicologic manifestations. We report a patient presenting to our hospital with Mobitz type II atrioventricular block after drinking herbal tea prepared from oleander leaves. Three hours after admission, a 200-mg empiric dose of digoxin-specific Fab antibody fragments was administered intravenously over 30 minutes...
October 2015: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
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