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https://www.readbyqxmd.com/read/29785156/correlations-of-aldehyde-dehydrogenase-1-aldh1-expression-with-traditional-prognostic-parameters-and-different-molecular-subtypes-of-breast-carcinoma
#1
Piyabi Sarkar, Keya Basu, Pubali Sarkar, Uttara Chatterjee, Madhumita Mukhopadhyay, Manoj Kumar Choudhuri, Diptendra Kumar Srakar
Background and aim: Breast cancer, a heterogeneous disease, is the most common cause of cancer-related death in women worldwide. Despite considerable developments in treatment modalities, a subset of patients with advanced-stage breast carcinoma display poor prognosis. Breast cancer heterogeneity and risk of recurrence could be explained with the help of cancer stem cell hypothesis. Stem cells have the capacity to self-renew and differentiate into multiple cell types. Aldehyde dehydrogenase-1 (ALDH1), an enzyme responsible for the oxidation of intracellular aldehydes, contributes to normal and tumor stem cell differentiation...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29780673/breast-fibroblasts-in-both-cancer-and-normal-tissues-induce-phenotypic-transformation-of-breast-cancer-stem-cells-a-preliminary-study
#2
Bixiao Wang, Chunfang Xi, Mingwei Liu, Haichen Sun, Shuang Liu, Lei Song, Hua Kang
Background: Breast cancer stem cells (BCSCs) are associated with the invasion of breast cancer. In recent years, studies have demonstrated different phenotypes among BCSCs. Furthermore, BCSCs of diverse phenotypes are present at different tumour sites and different histological stages. Fibroblasts are involved in the phenotypic transformation of BCSCs. Cancer-associated fibroblasts (CAFs) participate in the induction of epithelial-mesenchymal transition, thereby promoting the acquisition of stem cell characteristics, but little is known about the role of normal fibroblasts (NFs) in the phenotypic transformation of BCSCs or about the effect of CAFs and NFs on BCSC phenotypes...
2018: PeerJ
https://www.readbyqxmd.com/read/29779728/association-between-aldehyde-dehydrogenase-2-glu504lys-polymorphism-and-alcoholic-liver-disease
#3
Binxia Chang, Shuli Hao, Longyu Zhang, Miaomiao Gao, Ying Sun, Ang Huang, Guangju Teng, Baosen Li, David W Crabb, Praveen Kusumanchi, Li Wang, Suthat Liangpunsakul, Zhengsheng Zou
BACKGROUND: Only a subset of patients with excessive alcohol use develop alcoholic liver disease (ALD), though the exact mechanism is not completely understood. Once ingested, alcohol is metabolized by 2 key oxidative enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). There are 2 major ALDH isoforms, cytosolic and mitochondrial, encoded by the aldehyde ALDH1 and ALDH2 genes, respectively. The ALDH2 gene was hypothesized to alter genetic susceptibility to alcohol dependence and alcohol-induced liver diseases...
March 20, 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29779037/expression-of-cancer-stem-cell-markers-cd44-aldh1-and-p75ntr-in-actinic-cheilitis-and-lip-cancer
#4
Marcos Custódio, Cibele Pelissari, Thalita Santana, Marília Trierveiler
PURPOSE: The aim of this work was to evaluate the expression of the cancer stem cell (CSC) markers CD44, ALDH1 and p75NTR in the ultraviolet-induced lesions actinic cheilitis (AC) and lip squamous cell carcinoma (LSCC), and to correlate it with p53 expression. METHODS: Immunohistochemistry was performed in 4 cases of normal lip (NL), 43 of AC and 20 of LSCC. RESULTS: All cases were positive for CD44, showing a membranous staining without differences between the groups...
May 19, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29777274/the-natural-agent-4-vinylphenol-targets-metastasis-and-stemness-features-in-breast-cancer-stem-like-cells
#5
Hoi-Wing Leung, Chun-Hay Ko, Grace Gar-Lee Yue, Ingrid Herr, Clara Bik-San Lau
BACKGROUND AND PURPOSE: Cancer stem-like cells (CSC) are regarded as the source of tumour origins, metastasis and drug resistance, and limits current treatment regimens. Previously, we reported the first study of the anti-angiogenic and anti-tumour activities of 4-vinylphenol. To further examine the therapeutic role of 4-vinylphenol, the inhibitory effects of 4-vinylphenol on cancer stemness, drug resistance and metastasis in breast cancer were investigated in the present study. STUDY DESIGN AND METHODS: We enriched parental MDA-MB-231 cells with CSCs in serum-free medium to give spheroids...
May 18, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29753392/the-prognostic-impact-of-cancer-stem-like-cell-biomarker-aldehyde-dehydrogenase-1-aldh1-in-ovarian-cancer-a-meta-analysis
#6
Ilary Ruscito, Silvia Darb-Esfahani, Hagen Kulbe, Filippo Bellati, Ilaria Grazia Zizzari, Hassan Rahimi Koshkaki, Chiara Napoletano, Donatella Caserta, Aurelia Rughetti, Mirjana Kessler, Jalid Sehouli, Marianna Nuti, Elena Ioana Braicu
OBJECTIVE: To investigate the association of cancer stem cell biomarker aldehyde dehydrogenase-1 (ALDH1) with ovarian cancer patients' prognosis and clinico-pathological characteristics. METHODS: The electronic searches were performed in January 2018 through the databases PubMed, MEDLINE and Scopus by searching the terms: "ovarian cancer" AND "immunohistochemistry" AND ["aldehyde dehydrogenase-1" OR "ALDH1" OR "cancer stem cell"]...
May 10, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29747452/cytokeratin-19-krt19-has-a-role-in-the-reprogramming-of-cancer-stem-cell-like-cells-to-less-aggressive-and-more-drug-sensitive-cells
#7
Subbroto Kumar Saha, Kyeongseok Kim, Gwang-Mo Yang, Hye Yeon Choi, Ssang-Goo Cho
Cytokeratin 19 ( KRT19 ) is a cytoplasmic intermediate filament protein, which is responsible for structural rigidity and multipurpose scaffolds. In several cancers, KRT19 is overexpressed and may play a crucial role in tumorigenic transformation. In our previous study, we revealed the role of KRT19 as signaling component which mediated Wnt/NOTCH crosstalk through NUMB transcription in breast cancer. Here, we investigated the function of KRT19 in cancer reprogramming and drug resistance in breast cancer cells...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29744876/flubendazole-elicits-anti-metastatic-effects-in-triple-negative-breast-cancer-via-stat3-inhibition
#8
Eunhye Oh, Yoon-Jae Kim, Hyunsook An, Daeil Sung, Tae-Min Cho, Lee Farrand, Seojin Jang, Jae Hong Seo, Ji Young Kim
Tumor metastasis remains the cause of 90% of cancer-related deaths. Cancer stem cells (CSC) are thought to be responsible for the aggressive and metastatic nature of triple-negative breast cancers (TNBC), and new therapeutic strategies are being devised to target them. Flubendazole (FLU) is a widely used anthelmintic agent that also exhibits anticancer activity in several cancer types. The aim of the present study was to characterize the mechanism of action of FLU on breast cancer stem cell (BCSC)-like properties and metastasis in TNBC...
May 9, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29738110/genotoxic-stress-induces-sca-1-expressing-metastatic-mammary-cancer-cells
#9
Jianlin Gong, Benjamin J Lang, Desheng Weng, Takanori Eguchi, Ayesha Murshid, Thiago J Borges, Sachin Doshi, Baizheng Song, Mary Ann Stevenson, Stuart K Calderwood
We describe a cell damage-induced phenotype in mammary carcinoma cells involving acquisition of enhanced migratory and metastatic properties. Induction of this state by radiation required increased activity of the Ptgs2 gene product cyclooxygenase 2 (Cox2), secretion of its bioactive lipid product prostaglandin E2 (PGE2) and the activity of the PGE2 receptor EP4. Although largely transient, decaying to low levels in a few days to a week, this phenotype was cumulative with damage and levels of cell markers Sca-1 and ALDH1 increased with treatment dose...
May 8, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29733965/mesenchymal-stem-cell-s-secretome-promotes-selective-enrichment-of-cancer-stem-like-cells-with-specific-cytogenetic-profile
#10
Gema Jiménez, Michael Hackenberg, Purificación Catalina, Houria Boulaiz, Carmen Griñán-Lisón, María Ángel García, Macarena Perán, Elena López-Ruiz, Alberto Ramírez, Cynthia Morata-Tarifa, Esther Carrasco, Margarita Aguilera, Juan Antonio Marchal
Cancer stem cells (CSCs) are responsible for tumour initiation, metastasis and cancer recurrence, however the involvement of microenvironment is crucial. Here, we have analyzed how human mesenchymal stem cells (MSCs)-derived conditioned medium (CM) affect colon and melanoma CSCs enrichment and maintenance. Our results strongly suggest that the secretome of CM-MSCs selects and maintains subpopulations with high expression of CSCs markers and ALDH1 activity, low proliferation rates with G1 phase arrest, and notably retain in vivo these properties...
May 4, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29730663/clinicopathological-and-prognostic-significance-of-cancer-stem-cell-markers-in-ovarian-cancer-patients-evidence-from-52-studies
#11
Yifeng Tao, Hui Li, Rongyong Huang, Dan Mo, Tian Zeng, Min Fang, Meiqin Li
BACKGROUND/AIMS: Relevant markers of cancer stem cells (CSCs) may serve as commonly used biomarkers of ovarian cancer (OC). However, their actual clinicopathological and prognostic significance remains inconclusive. Thus, we conducted a meta-analysis to quantitatively evaluate the association between the expression of CSC-relevant markers (ALDH1, CD117, CD133, and CD44) and OC. METHODS: We used an odds ratio (OR) and a hazard ratio (HR) with a 95% confidence interval (CI) to estimate the effects by analyzing 52 studies from a literature search...
April 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29725036/initial-characterisation-of-adult-human-ovarian-cell-populations-isolated-by-ddx4-expression-and-aldehyde-dehydrogenase-activity
#12
Yvonne L Clarkson, Marie McLaughlin, Martin Waterfall, Cheryl E Dunlop, Paul A Skehel, Richard A Anderson, Evelyn E Telfer
The existence of a population of putative stem cells with germline developmental potential (oogonial stem cells: OSCs) in the adult mammalian ovary has been marked by controversy over isolation methodology and potential for in-vitro transformation, particularly where cell sorting has been based on expression of DEAD box polypeptide 4 (DDX4). This study describes a refined tissue dissociation/fluorescence-activated cell sorting (FACS) protocol for the ovaries of adult women which results in increased cell viability and yield of putative OSCs...
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29693231/lnc-rna-h19-is-associated-with-poor-prognosis-in-breast-cancer-patients-and-promotes-cancer-stemness
#13
Hidetaka Shima, Kumiko Kida, Shoko Adachi, Akimitsu Yamada, Sadatoshi Sugae, Kazutaka Narui, Yohei Miyagi, Mayuko Nishi, Akihide Ryo, Soichiro Murata, Hideki Taniguchi, Yasushi Ichikawa, Takashi Ishikawa, Itaru Endo
PURPOSE: Aldehyde dehydrogenase1 (ALDH1) is widely accepted as a stem cell marker for normal breast as well as in breast cancer. Although the clinical impact of ALDH1 was observed in our previous study, we do not know how ALDH1 affects stem cell features resulting in worsening of prognosis in breast cancer. The purpose of this study is to explore ALDH1-related gene and its function on cancer stem cell (CSC). METHODS: In five cases of ALDH1-positive triple-negative breast cancer, mRNA expression profile was compared between ALDH1-positive and ALDH1-negative cells by Affymetrix microarray analysis after microdissection...
April 24, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29693155/assessing-stemness-and-proliferation-properties-of-the-newly-established-colon-cancer-stem-cell-line-csc480-and-novel-approaches-to-identify-dormant-cancer-cells
#14
Faisal Alowaidi, Saeed Mujahid Hashimi, Naif Alqurashi, Reem Alhulais, Saso Ivanovski, Bernadette Bellette, Adrian Meedenyia, Alfred Lam, Stephen Wood
To date two questions that remain unanswered regarding cancer are the following: i) how is it initiated, and ii) what is the role that cancer stem cells (CSCs) play in the disease process? Understanding the biology of CSCs and how they are generated is pivotal for the development of successful treatment regimens. To date, the lack of a representative cell model has prevented the successful identification and eradication of CSCs in vivo. The current methods of CSC identification are dependent on the protocol used to generate these cells, which has introduced variation and made the identification process more complicated...
April 23, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29685462/aldh1-and-tumor-infiltrating-lymphocytes-as-predictors-for-neoadjuvant-chemotherapy-response-in-breast-cancer
#15
Anbok Lee, Kyu Yeoun Won, Sung-Jig Lim, Sun Young Cho, Sang-Ah Han, SaeGwang Park, Jeong-Yoon Song
Many studies have reported that Aldehyde dehydrogenase 1 (ALDH1) and tumor-infiltrating lymphocytes (TIL) are related to breast cancer prognosis. However, the clinical significance of ALDH1 and tumor-infiltrating immune cells in breast cancer has not been fully investigated in patients who received neoadjuvant chemotherapy (NAC). We studied the significance of the expression of ALDH1 and the population of TIL for predicting the prognosis and chemotherapeutic response of patients with breast cancer who had received NAC...
April 18, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29662319/clinicopathological-characteristics-and-prognostic-value-of-the-cancer-stem-cell-marker-aldh1-in-ovarian-cancer-a-meta-analysis
#16
Wenge Zhao, Chuanxin Zang, Tingting Zhang, Jia Li, Ruijuan Liu, Fubin Feng, Qingliang Lv, Liang Zheng, Jinhui Tian, Changgang Sun
Background: The clinicopathological and prognostic values of the cancer stem cell marker aldehyde dehydrogenase 1 (ALDH1) in ovarian cancer (OC) remain unknown. The aim of our meta-analysis was to evaluate ALDH1's association with clinicopathological characteristics and its prognostic significance in patients with OC. Materials and methods: PubMed, Embase, and China Biology Medicine were systematically searched for eligible studies (up to October 2017). Pooled odds ratios (ORs) or hazard ratios (HRs) with 95% CIs were used to evaluate the association of ALDH1 expression with clinicopathological features and survival outcomes...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29660692/aggressive-phenotype-of-cells-disseminated-via-hematogenous-and-lymphatic-route-in-breast-cancer-patients
#17
Aleksandra Markiewicz, Anna Nagel, Jolanta Szade, Hanna Majewska, Jaroslaw Skokowski, Barbara Seroczynska, Tomasz Stokowy, Marzena Welnicka-Jaskiewicz, Anna J Zaczek
Intratumoral heterogeneity of breast cancer remains a major challenge in successful treatment. Failure of cancer therapies can also be accredited to inability to systemically eradicate cancer stem cells (CSCs). Recent evidence points to the role of epithelial-mesenchymal transition (EMT) in expanding the pool of tumor cells with CSCs features. Thus, we assessed expression level as well as heterogeneity of CSCs markers in primary tumors (PT), lymph node metastasis (LNM), and circulating tumor cells (CTCs)-enriched blood fractions in order to correlate them with signs of EMT activation as well as clinicopathological data of breast cancer patients...
April 13, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29627827/lgr5-cd44-epcam-strictly-defines-cancer-stem-cells-in-human-colorectal-cancer
#18
Zhengwei Leng, Qinghua Xia, Jinhuang Chen, Yong Li, Jiqian Xu, Ende Zhao, Hai Zheng, Walden Ai, Jiangchuan Dong
BACKGROUND/AIMS: Although EpCAM+CD44+ cells exhibit more stem-like properties than did EpCAM-CD44- cells, the specificity of EpCAM combined with CD44 in defining CSCs needs further improvement. Lgr5 is used as a biomarker to isolate cancer stem cells (CSCs) in colorectal cancer. However, it remains unclear whether Lgr5, along with EpCAM and CD44, can further identify and define CSCs in colorectal cancer. METHODS: Lgr5+CD44+EpCAM+, Lgr5+CD44+EpCAM-, Lgr5+CD44-EpCAM+, Lgr5-CD44+EpCAM+, and Lgr5-CD44-EpCAM-cells were separately isolated using fluorescence-activated cell sorting (FACS)...
March 29, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29603383/tgf-%C3%AE-mediated-lefty-akt-gsk-3%C3%AE-snail-axis-modulates-epithelial-mesenchymal-transition-and-cancer-stem-cell-properties-in-ovarian-clear-cell-carcinomas
#19
Toshihide Matsumoto, Ako Yokoi, Miki Hashimura, Yasuko Oguri, Masashi Akiya, Makoto Saegusa
Advanced ovarian clear cell carcinoma (OCCCa) shows poor prognosis with chemoresistance, which is associated with epithelial-mesenchymal transition (EMT)/cancer stem cell (CSC) features. The left-right determination factor (LEFTY), a novel member of the TGF-β superfamily, is a marker of stemness. Here we focused on the functional roles of LEFTY in OCCCas. OCCCa cell lines that were cultured in STK2, a serum-free medium for mesenchymal stem cells, or treated with TGF-β1 underwent morphological changes toward an EMT appearance, along with increased expression of LEFTY and Snail...
March 30, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29568377/molecular-profiling-of-aldh1-colorectal-cancer-stem-cells-reveals-preferential-activation-of-mapk-fak-and-oxidative-stress-pro-survival-signalling-pathways
#20
Radhakrishnan Vishnubalaji, Muthurangan Manikandan, Mohamed Fahad, Rimi Hamam, Musaad Alfayez, Moustapha Kassem, Abdullah Aldahmash, Nehad M Alajez
Tumour heterogeneity leads to variable clinical response and inaccurate diagnostic and prognostic assessment. Cancer stem cells (CSCs) represent a subpopulation responsible for invasion, metastasis, therapeutic resistance, and recurrence in many human cancer types. However, the true identity of colorectal cancer (CRC) SCs remains elusive. Here, we aimed to characterize and define the gene expression portrait of CSCs in CRC-model SW403 cells. We found that ALDH+ positive cells are clonogenic and highly proliferative; their global gene expression profiling-based molecular signature revealed gene enrichment related to DNA damage, MAPK, FAK, oxidative stress response, and Wnt signalling...
March 2, 2018: Oncotarget
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