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LUNG CANCER, MEDIASTINAL TUMOR

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https://www.readbyqxmd.com/read/28293012/-synchronous-triple-primary-lung-adenocarcinomas-one-of-which-showing-a-thin-walled-cavity-nodule-report-of-a-case
#1
Takefumi Doi, Toshihiko Sakamoto
A 74-year-old woman was referred to our hospital to investigate a right apical segment (S1)nodule which was increasing gradually. Chest computed tomography (CT) scan showed three lesions in right S1, posterior segment(S2) and superior segment(S6). S6 lesion was a thin-walled cavity enlarging gradually with same appearance. The S1 nodule was diagnosed as adenocarcinoma by CT guided biopsy. Since the possibility of lung cancer couldn't be denied for S6 lesion, right upper lobectomy and S6 segmentectomy with mediastinal lymph node dissection was performed...
March 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28267977/indications-for-adjuvant-mediastinal-radiotherapy-in-surgically-resected-small-cell-lung-cancer
#2
Elliot Wakeam, Meredith Giuliani, Natasha B Leighl, Samuel R G Finlayson, Thomas K Varghese, Gail E Darling
BACKGROUND: Adjuvant mediastinal radiotherapy (AMR) is used after surgical resection for patients with small cell lung cancer (SCLC), but data guiding its use are scant. We sought to examine whether AMR was associated with an improvement in survival for resected SCLC patients and to define subpopulations who should be selected for AMR. METHODS: Patients undergoing lobectomy, pneumonectomy, and sublobar resection for SCLC were identified in the National Cancer Database (2004 to 2013)...
March 3, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28256095/effect-of-visceral-pleural-invasion-on-the-prognosis-of-patients-with-lymph-node-negative-non-small-cell-lung-cancer
#3
Dan Tian, Yuquan Pei, Qingfeng Zheng, Jianzhi Zhang, Shaolei Li, Xing Wang, Dongmei Lin, Yue Yang
BACKGROUND: Visceral pleural invasion (VPI) is an adverse prognostic factor in non-small cell lung cancer (NSCLC); however, its effect in relation to tumor size remains under debate. To better understand the prognostic impact and potential consequences for staging, we examined correlations between VPI and clinicopathologic characteristics in patients with NSCLC, particularly those with lymph node negative NSCLC. METHODS: We retrospectively analyzed 813 cases of radically resected NSCLC treated in our institution between December 2005 and December 2011...
March 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28238444/pet-ct-in-presurgical-lymph-node-staging-in-non-small-cell-lung-cancer-the-importance-of-false-negative-and-false-positive-findings
#4
A Bustos García de Castro, J Ferreirós Domínguez, R Delgado Bolton, C Fernández Pérez, B Cabeza Martínez, M García García-Esquinas, J L Carreras Delgado
OBJECTIVE: To assess the importance of false-negative and false-positive findings in computed tomography (CT) and (18)F-FDG positron emission tomography (PET) in mediastinal lymph node staging in patients undergoing surgery for non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: This retrospective study included 113 consecutive patients and 120 resected NSCLCs; 22 patients received neoadjuvant treatment. We compared the findings on preoperative (18)F-FDG PET-CT studies with the postoperative pathology findings...
February 23, 2017: Radiología
https://www.readbyqxmd.com/read/28230028/leucine-rich-repeats-and-immunoglobulin-like-domains-protein-1-and-fascin-actin-bundling-protein-1-expression-in-nonsmall-cell-lung-cancer
#5
Juanjuan Zhang, Xiaoyan Wang, Yijie Zhang, Jingcan Wu, Nannan Zhou
OBJECTIVE: To assess the clinical significance of leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) and fascin actin-bundling protein 1 (Fascin-1) expression in nonsmall cell lung cancer (NSCLC). MATERIALS AND METHODS: Six-one NSCLC patients were included in this study. The expression of LRIG1 and Fascin-1 was assayed in the tumor tissue and relative normal lung tissue of the 61 NSCLC patients by immunohistochemistry. The relationship between LRIG1, Fascin-1 expression pattern and lung cancer patients' clinical pathology characteristics was evaluated...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28223676/-multiple-salvage-radiotherapies-for-metachronous-lymph-node-metastasis-from-gastric-cancer-contributed-to-long-term-management-of-disease
#6
Naoto Hori, Shunsuke Kagawa, Satoru Kikuchi, Shinji Kuroda, Megumi Watanabe, Shuichi Sakamoto, Tetsuya Kagawa, Kazuya Kuwada, Tetsushi Kubota, Hiroyuki Kishimoto, Masahiko Nishizaki, Norihisa Katayama, Toshiyoshi Fujiwara
A 70-year-old man who underwent gastrectomy for Stage III C gastric cancer developed lymph node(LN)metastasis posterior to the pancreatic head 3 years after the radical surgery.He was first treated with radiotherapy(RT)followed by chemotherapy.The irradiated tumor regressed completely.However, the cancer relapsed in a single para-aortic LN and he was treated with RT to the lesion followed by chemotherapy.Although it completely regressed, later, lung metastasis was observed.The lung lesions were well suppressed by switching to docetaxel; however, the cancer relapsed again in a mediastinal LN, and it was not responsive to docetaxel...
February 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28206951/missed-lung-cancer-when-where-and-why
#7
Annemilia Del Ciello, Paola Franchi, Andrea Contegiacomo, Giuseppe Cicchetti, Lorenzo Bonomo, Anna Rita Larici
Missed lung cancer is a source of concern among radiologists and an important medicolegal challenge. In 90% of the cases, errors in diagnosis of lung cancer occur on chest radiographs. It may be challenging for radiologists to distinguish a lung lesion from bones, pulmonary vessels, mediastinal structures, and other complex anatomical structures on chest radiographs. Nevertheless, lung cancer can also be overlooked on computed tomography (CT) scans, regardless of the context, either if a clinical or radiologic suspect exists or for other reasons...
March 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28176005/prognosis-of-video-assisted-thoracoscopic-pulmonary-metastasectomy-in-patients-with-colorectal-cancer-lung-metastases-an-analysis-of-154-cases
#8
Fenghao Sun, Li Chen, Mengkun Shi, Xiaodong Yang, Ming Li, Xinyu Yang, Xiyu Dai, Cheng Zhan, Yu Shi, Qun Wang
PURPOSE: Video-assisted thoracoscopic surgery (VATS) is widely used in thoracic surgery and increasingly applied to pulmonary metastasectomy. The purpose of this study was to identify prognostic factors of patients undergoing VATS pulmonary metastasectomy from colorectal cancer (CRC). METHODS: Between January 2005 and June 2015, a total of 154 patients underwent VATS pulmonary metastasectomy from CRC. Patient demographic data and characteristics of the primary tumor and pulmonary metastasis were analyzed to identify factors significantly correlated with prognosis...
February 7, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28174385/-long-term-complete-response-in-postoperative-multiple-lung-and-mediastinal-lymph-node-metastases-of-esophageal-cancer-using-systemic-chemotherapy-with-dcf-treatment-a-case-report
#9
Chihiro Katsumi, Takeo Bamba, Satoru Nakagawa, Masaki Aizawa, Atsushi Matsuki, Hiroshi Yabusaki, Keiichi Homma
A 59-year-old man was diagnosed with advanced thoracic esophageal cancer.He underwent neoadjuvant chemotherapy with cisplatin(CDDP), 5-fluorouracil(5-FU)(CF)followed by transthoracic esophagectomy with three-field lymphadenectomy. Histopathological examination revealed that the tumor was poorly differentiated squamous cell carcinoma invading the adventitia with 6 regional lymph node metastases.Four months after surgery, follow-up thoracic computed tomography (CT)showed multiple lung and mediastinal lymph node metastases...
January 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28174383/-a-case-of-synchronous-double-cancer-of-the-lung-and-stomach-that-responded-to-cisplatin-and-s-1-combination-chemotherapy
#10
Tomohide Sugiyama, Takashi Kasai, Yoichi Nakamura, Yukari Kamiyama, Kiyoshi Mori
A 55-year-old man experienced weight loss, as noted by a physician who was examining him for hypertension. Upper gastrointestinal endoscopy revealed a tumor lesion with an ulcer on the posterior wall of the greater curvature. A biopsy confirmed the presence of an adenocarcinoma(HER2 negative), and demonstrated enlarged para-aortic lymph nodes. Thus, stage IV type 3 ulcer infiltration-type gastric cancer was diagnosed. Computed tomography was included in the examination, and demonstrated nodular shadows in the right lower lobe and enlarged mediastinal nodes, as well as bilateral multiple granular shadows...
January 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28152555/stent-implantation-for-superior-vena-cava-syndrome-of%C3%A2-malignant-cause
#11
Felix A Büstgens, Reinhard Loose, Joachim H Ficker, Michael Wucherer, Michael Uder, Ralf Adamus
Purpose The purpose of this paper is the retrospective analysis of endovascular therapy for the treatment of superior vena cava syndrome (SVCS) of malignant cause. This study focuses on the effectiveness of the therapy regarding the duration of remission, symptom control and practicability. Materials and Methods From January 2003 to November 2012, therapeutic implantation of one or more stents was performed in 141 patients suffering from SVCS. The medical history was retrospectively researched using digitalized patient files...
February 2, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28149548/safety-and-feasibility-of-uniportal-video-assisted-thoracoscopic-surgery-for-locally-advanced-non-small-cell-lung-cancer
#12
Junqiang Fan, Jie Yao, Qi Wang, Zhibo Chang
BACKGROUND: Conventional video-assisted thoracoscopic surgery (VATS) lobectomy for locally advanced non-small cell lung cancer (NSCLC) is a feasible and safe surgery in high-volume centers with significant VATS experience. Uniportal VATS lobectomy has been recently been reported to be a promising, less invasive approach. The purpose of this study is to explore the safety and feasibility of uniportal video-assisted thoracoscopic surgery (U-VATS) for the treatment of patients with locally advanced NSCLC...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28140453/lung-cancer-major-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#13
Ramón Rami-Porta, Hisao Asamura, William D Travis, Valerie W Rusch
Answer questions and earn CME/CNE The revision for the eighth edition of the tumor, node, and metastasis (TNM) classification of lung cancer was based on analyses of the International Association for the Study of Lung Cancer database, which included 77,156 evaluable patients diagnosed with lung cancer from 1999 to 2010. Among tumor (T) descriptors, the following new tumor-size groups were created: T1a, ≤1 cm; T1b, >1 to 2 cm; T1c, >2 to 3 cm; T2a, >3 to 4 cm; T2b, >4 to 5 cm; T3, >5 to 7 cm; and T4, >7 cm...
March 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28130707/topography-of-the-sentinel-node-according-to-the-affected-lobe-in-lung-cancer
#14
J M Galbis-Caravajal, A Lafuente-Sanchis, M Estors-Guerrero, N Martinez-Hernández, C Fuster-Diana, A Cremades, Á Zúñiga
PURPOSE: The objective of this study is to describe the anatomic location of the sentinel lymph node (SLN) of patients with lung carcinoma and to analyze its relationship with the characteristics of the tumor. PATIENTS AND METHODS: 98 Stage I lung cancer patients were included in the study. SLN was marked just after performing the thoracotomy by injecting peritumorally 0.25 mCi of nanocolloid of albumin (Nanocol1) labeled with Tc-99 m in 0.3 ml, and later, it was resected...
January 27, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28130689/comparison-of-machine-learning-methods-for-classifying-mediastinal-lymph-node-metastasis-of-non-small-cell-lung-cancer-from-18-f-fdg-pet-ct-images
#15
Hongkai Wang, Zongwei Zhou, Yingci Li, Zhonghua Chen, Peiou Lu, Wenzhi Wang, Wanyu Liu, Lijuan Yu
BACKGROUND: This study aimed to compare one state-of-the-art deep learning method and four classical machine learning methods for classifying mediastinal lymph node metastasis of non-small cell lung cancer (NSCLC) from (18)F-FDG PET/CT images. Another objective was to compare the discriminative power of the recently popular PET/CT texture features with the widely used diagnostic features such as tumor size, CT value, SUV, image contrast, and intensity standard deviation. The four classical machine learning methods included random forests, support vector machines, adaptive boosting, and artificial neural network...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28125698/late-course-adaptive-adjustment-based-on-metabolic-tumor-volume-changes-during-radiotherapy-may-reduce-radiation-toxicity-in-patients-with-non-small-cell-lung-cancer
#16
Linlin Xiao, Ning Liu, Guifang Zhang, Hui Zhang, Song Gao, Zheng Fu, Suzhen Wang, Qingxi Yu, Jinming Yu, Shuanghu Yuan
To reduce the high risk of radiation toxicity and enhance the quality of life of patients with non-small cell lung cancer (NSCLC), we quantified the metabolic tumor volumes (MTVs) from baseline to the late-course of radiotherapy (RT) by fluorodeoxyglucose positron emission tomography computerized tomography (FDG PET-CT) and discussed the potential benefit of late-course adaptive plans rather than original plans by dose volume histogram (DVH) comparisons. Seventeen patients with stage II-III NSCLC who were treated with definitive conventionally fractionated RT were eligible for this prospective study...
2017: PloS One
https://www.readbyqxmd.com/read/28110489/video-assisted-laser-resection-of-lung-metastases-feasibility-of-a-new-surgical-technique
#17
Christian Meyer, Detlef Bartsch, Nikolas Mirow, Andreas Kirschbaum
Background Our pilot study describes our initial experience to do a laser resection of lung metastases under video-assisted thoracoscopic control via a minithoracotomy. With this approach, if needed, mediastinal lymphadenectomy is also possible. Methods In this study, 15 patients (11 men and 4 women, mean age: 60 years) with resectable lung metastases of different solid primary tumors (colorectal cancer in seven patients, melanoma in three patients, renal cell carcinoma in two patients, and one each with oropharyngeal cancer, breast cancer, and seminoma) were included...
January 22, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28109572/subcarinal-lymph-nodes-should-be-dissected-in-all-lobectomies-for-non-small-cell-lung-cancer-regardless-of-primary-tumor-location
#18
Jens Eckardt, Erik Jakobsen, Peter B Licht
BACKGROUND: Mediastinal staging is of paramount importance for planning of treatment in non-small cell lung cancer (NSCLC). Single institution reports recently claimed that subcarinal lymph node dissection during resection of upper lobe NSCLC could be spared. We used a complete national lung cancer registry to investigate patterns of unsuspected mediastinal lymph node involvement after lobectomy. METHODS: During an 11-year period (2004 to 2014) 5,577 consecutive patients who underwent operations for NSCLC were investigated for unsuspected mediastinal lymph node involvement (N2 disease) discovered at final histopathology...
January 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28029320/pulmonary-infiltrates-in-a-patient-with-advanced-melanoma
#19
Charles A Powell
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
March 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27991022/-minimal-invasive-esophageal-resection-with-anastomosis-on-the-neck-mckeown-our-experiences-after-20-cases
#20
Elemér Mohos, Attila Nagy, György Szabados, György Réti, Tamás Kovács, Zoltán Jánó, Csaba Berki, József Mohay, Lóránt Szabó, Krisztina Bene, Gábor Bognár, Myroslav Horzov, Petra Mohos, Gábor Sándor, Gábor Tornai, Péter Szenkovits, Tibor Nagy, Csaba Orbán, Vivien Herpai
OBJECTIVE: Esophageal resection is a traumatic intervention usually performed on patients with poor condition, resulting high mortality and morbidity. To improve the high incidence of complications, minimal invasive interventions were introduced. The results of the thoracoscopically and laparoscopically performed esophageal resection (McKeown) was investigated after 20 cases and the technical details of the surgical intervention are presented. PATIENTS AND METHOD: 20 thoracoscopic esophageal resection with laparoscopic gastric tube formation (sec...
December 2016: Magyar Sebészet
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