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https://www.readbyqxmd.com/read/29137004/the-principle-of-preserving-outflow-structures-in-partial-alpps-a-commentary-on-segment-4-a-key-point-of-alpps-procedure
#1
Henrik Petrowsky, Pierre-Alain Clavien
No abstract text is available yet for this article.
December 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29137003/segment-4-a-key-point-of-alpps-procedure
#2
Giuseppe Maria Ettorre, Nicola Guglielmo, Roberto Luca Meniconi, Giovanni Battista Levi Sandri, Marco Colasanti, Giovanni Vennarecci
No abstract text is available yet for this article.
December 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29136967/are-we-ready-to-perform-fully-minimally-invasive-alpps
#3
Giovanni Battista Levi Sandri, Francesco Guerra
No abstract text is available yet for this article.
December 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29046476/tracking-mesenchymal-stem-cell-contributions-to-regeneration-in-an-immunocompetent-cartilage-regeneration-model
#4
Daniela Zwolanek, María Satué, Verena Proell, José R Godoy, Kathrin I Odörfer, Magdalena Flicker, Sigrid C Hoffmann, Thomas Rülicke, Reinhold G Erben
It is currently controversially discussed whether mesenchymal stem cells (MSC) facilitate cartilage regeneration in vivo by a progenitor- or a nonprogenitor-mediated mechanism. Here, we describe a potentially novel unbiased in vivo cell tracking system based on transgenic donor and corresponding immunocompetent marker-tolerant recipient mouse and rat lines in inbred genetic backgrounds. Tolerance of recipients was achieved by transgenic expression of an immunologically neutral but physicochemically distinguishable variant of the marker human placental alkaline phosphatase (ALPP)...
October 19, 2017: JCI Insight
https://www.readbyqxmd.com/read/29046260/assessment-of-liver-regeneration-after-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-a-comparative-study-with-portal-vein-ligation
#5
Ruo-Fan Sheng, Li Yang, Kai-Pu Jin, He-Qing Wang, Hao Liu, Yuan Ji, Cai-Xia Fu, Meng-Su Zeng
BACKGROUND: To investigate the diagnostic value of diffusion kurtosis imaging (DKI) and diffusion-weighted imaging (DWI) in assessing liver regeneration after associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) compared with portal vein ligation (PVL). METHODS: Thirty rats were divided into the ALPPS, PVL, and control groups. DKI and DWI were performed before and 7 days after surgery. Corrected apparent diffusion (D), kurtosis (K) and apparent diffusion coefficient (ADC) were calculated and compared, radiologic-pathologic correlations were evaluated...
October 15, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29032374/the-alpps-approach-for-colorectal-liver-metastases-impact-of-kras-mutation-status-in-survival
#6
Matteo Serenari, Fernando Andres Alvarez, Victoria Ardiles, Martin de Santibañes, Juan Pekolj, Eduardo de Santibañes
BACKGROUND/AIMS: Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations influence survival after hepatectomy for colorectal liver metastases (CRLM). However, their prognostic significance has never been evaluated in patients who undergo Associating Liver Partition and Portal vein occlusion for Staged hepatectomy (ALPPS). METHODS: Between June 2011 and March 2016, 26 patients underwent ALPPS for CRLM. Complications were classified according to the Clavien-Dindo classification...
October 14, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28990002/two-cases-of-alpps-procedure-simultaneous-alpps-and-colorectal-resection-and-alpps-procedure-for-hepatic-malignancy-larger-than-15-centimeter
#7
Young Il Choi, Hyung Hwan Moon, Dong Hoon Shin
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has recently been introduced as a new surgical technique to increase future liver remnant in patients with marginal liver volume contemplating major liver resection. We herein present two cases. Case 1: a 68-year-old male patient with colorectal liver metastasis was referred to our department. The future liver remnant (FLR) was 22%. We performed first-stage ALPPS and colorectal surgery concurrently and second stage operation was performed 8 days later...
August 2017: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/28961380/effects-of-magnetic-stimulation-on-urodynamic-stress-incontinence-refractory-to-pelvic-floor-muscle-training-in-a-randomized-sham-controlled-study
#8
Tomonori Yamanishi, Tsuneki Suzuki, Ryo Sato, Kanya Kaga, Mayuko Kaga, Miki Fuse
OBJECTIVE: The aim of the present study was to evaluate the effect of magnetic stimulation on urodynamic stress incontinence refractory to pelvic floor muscle training in a randomized sham-controlled study. METHODS: Female patients with urodynamic stress incontinence who had not been cured by pelvic floor muscle training were randomly assigned at a ratio of 2 : 1 to either active treatment or sham treatment for 10 weeks. The randomization was made using magnetic cards for individuals indicating active or sham stimulation...
September 29, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28941575/bioenergetic-adaptations-of-the-human-liver-in-the-alpps-procedure-how-liver-regeneration-correlates-with-mitochondrial-energy-status
#9
Henrique Alexandrino, Anabela Rolo, João S Teodoro, Henrique Donato, Ricardo Martins, Marco Serôdio, Mónica Martins, José G Tralhão, Filipe Caseiro Alves, Carlos Palmeira, Francisco Castro E Sousa
BACKGROUND: The Associating Liver Partition and Portal Ligation for Staged Hepatectomy (ALPPS) depends on a significant inter-stages kinetic growth rate (KGR). Liver regeneration is highly energy-dependent. The metabolic adaptations in ALPPS are unknown. AIMS: i) Assess bioenergetics in both stages of ALPPS (T1 and T2) and compare them with control patients undergoing minor (miHp) and major hepatectomy (MaHp), respectively; ii) Correlate findings in ALPPS with volumetric data; iii) Investigate expression of genes involved in liver regeneration and energy metabolism...
September 20, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28917644/alpps-as-a-salvage-procedure-after-insufficient-future-liver-remnant-hypertrophy-following-portal-vein-occlusion
#10
Marcelo Enne, Erik Schadde, Bergthór Björnsson, Roberto Hernandez Alejandro, Klaus Steinbruck, Eduardo Viana, Ricardo Robles Campos, Massimo Malago, Pierre-Alain Clavien, Eduardo De Santibanes, Brice Gayet
BACKGROUND: A minimum future liver remnant (FLR) of 30% is required to avoid post hepatectomy liver failure (PHLF). Portal vein occlusion (PVO) is the main strategy to induce hypertrophy of the FLR, but some patients will not reach sufficient FLR hypertrophy to enable resection. Recently ALPPS has emerged as a "Salvage Procedure" for PVO failure. The aim of this study was to report the short term outcomes of ALPPS following PVO failure. METHODS: A retrospective analysis of patients enrolled within the international ALPPS Registry between October 2012 and November 2015 (NCT01924741) was performed...
September 13, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28902669/alpps-improves-resectability-compared-with-conventional-two-stage-hepatectomy-in-patients-with-advanced-colorectal-liver-metastasis-results-from-a-scandinavian-multicenter-randomized-controlled-trial-ligro-trial
#11
Per Sandström, Bård I Røsok, Ernesto Sparrelid, Peter N Larsen, Anna L Larsson, Gert Lindell, Nicolai A Schultz, Bjorn A Bjørnbeth, Bengt Isaksson, Magnus Rizell, Bergthor Björnsson
OBJECTIVE: The aim of the study was to evaluate if associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) could increase resection rates (RRs) compared with two-stage hepatectomy (TSH) in a randomized controlled trial (RCT). BACKGROUND: Radical liver metastasis resection offers the only chance of a cure for patients with metastatic colorectal cancer. Patients with colorectal liver metastasis (CRLM) and an insufficient future liver remnant (FLR) volume are traditionally treated with chemotherapy with portal vein embolization or ligation followed by hepatectomy (TSH)...
September 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28861759/diffusion-outcomes-and-implementation-of-minimally-invasive-liver-surgery-a-snapshot-from-the-i-go-mils-italian-group-of-minimally-invasive-liver-surgery-registry
#12
Luca Aldrighetti, Francesca Ratti, Umberto Cillo, Alessandro Ferrero, Giuseppe Maria Ettorre, Alfredo Guglielmi, Felice Giuliante, Fulvio Calise
The Italian Group of MILS (I Go MILS) prospective registry was established in 2014 with the goals to create a hub for data and projects on a national basis and to promote the diffusion and implementation of MILS programs on a national scale. The primary endpoint of the present study is to give a snapshot of the real diffusion and outcomes of MILS in Italy, while analyzing the role of the registry in the implementation of MILS programs nationwide. The I Go MILS Registry is a prospective and intention-to-treat registry opened to any Italian center performing MILS, without restriction criteria based on number of procedures...
August 31, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28859921/greater-hypertrophy-can-be-achieved-with-associating-liver-partition-with-portal-vein-ligation-for-staged-hepatectomy-compared-to-conventional-staged-hepatectomy-but-with-a-higher-price-to-pay
#13
Daryl K A Chia, Zachery Yeo, Stanley E K Loh, Shridhar Ganpathi Iyer, Glenn Kunnath Bonney, Krishnakumar Madhavan, Alfred W C Kow
BACKGROUND: Associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) and conventional staged hepatectomy (CSH) are options for patients with unresectable liver tumors due to insufficient future liver remnant (FLR). METHODS: A retrospective comparison of clinical data, liver volumetry and surgical outcomes between 10 ALPPS and 29 CSH patients was performed. RESULTS: Patient demographics and disease characteristics were similar between both groups...
August 26, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28857819/partial-tipe-alpps-for-perihilar-cancer
#14
Yoshihiro Sakamoto, Masaru Matsumura, Suguru Yamashita, Naoki Ohkura, Kiyoshi Hasegawa, Norihiro Kokudo
No abstract text is available yet for this article.
August 29, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28844397/functional-considerations-in-alpps-consequences-for-clinical-management
#15
Martin Stockmann, Jan Bednarsch, Maciej Malinowski, Elisabeth Blüthner, Johann Pratschke, Daniel Seehofer, Maximilian Jara
BACKGROUND: Since perioperative morbidity and mortality in ALPPS are extraordinarily high, a deeper understanding of actual liver function during the procedure is essential to make the approach safer. METHODS: Data from 17 patients who underwent ALLPS were analyzed regarding their course of liver function capacity assessed with the LiMAx test and compared to an equal-sized matched cohort of patients that underwent PVE. RESULTS: A comparison of LiMAx prior to and following ALPPS Step I (330 [258-385] vs...
November 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28841539/salvage-transhepatic-arterial-embolization-after-failed-stage-i-alpps-in-a-patient-with-a-huge-hcc-with-chronic-liver-disease-a-case-report
#16
Zheng Wang, Yuanfei Peng, Qiman Sun, Xudong Qu, Min Tang, Yajie Dai, Zhaoyou Tang, Wan Yee Lau, Jia Fan, Jian Zhou
INTRODUCTION: The degree of hypertrophy of the future liver remnant (FLR) induced by associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in patients with HCC and chronic liver disease is often limited as compared with patients with a healthy liver. PRESENTATION OF CASE: We reported a 53-year-old male who had a huge HCC (14.8×12×9.4cm) arising from a background of hepatitis B liver fibrosis (METAVIR score F3). The ratio of the FLR/standard liver volume (SLV) was 23...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28829432/rat-model-of-the-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-alpps-procedure
#17
Erik Schadde, Martin Hertl, Stefan Breitenstein, Beatrice Beck-Schimmer, Martin Schläpfer
Recent clinical data support an aggressive surgical approach to both primary and metastatic liver tumors. For some indications, like colorectal liver metastases, the amount of liver tissue left behind after liver resection has become the main limiting factor of resectability of large or multiple liver tumors. A minimal amount of functional tissue is required to avoid the severe complication of post-hepatectomy liver failure, which has high morbidity and mortality. Inducing liver growth of the prospective remnant prior to resection has become more established in liver surgery, either in the form of portal vein embolization by interventional radiologists or in the form of portal vein ligation several weeks prior to resection...
August 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28809736/monosegmental-alpps-after-bilateral-hepatectomy
#18
Klaus Steinbrück, Marcelo D'Oliveira, Renato Cano, Marcelo Enne
Associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) has emerged as an alternative for patients with bilobar colorectal liver metastasis and a small future liver remnant (FLR). In cases of extensive disease, ALPPS can be performed, leaving only one segment of the liver as FLR. We describe a case of monosegmental ALPPS using segment 4 as FLR. In conclusion, ALPPS should be reserved for a selected group of patients. Monosegmental ALPPS is feasible, but should be performed by hepatobiliary surgeons in specialized centers...
September 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28806301/risk-adjustment-in-alpps-is-associated-with-a-dramatic-decrease-in-early-mortality-and-morbidity
#19
Michael Linecker, Bergthor Björnsson, Gregor A Stavrou, Karl J Oldhafer, Georg Lurje, Ulf Neumann, René Adam, Francois-René Pruvot, Stefan A Topp, Jun Li, Ivan Capobianco, Silvio Nadalin, Marcel Autran Machado, Sergey Voskanyan, Deniz Balci, Roberto Hernandez-Alejandro, Fernando A Alvarez, Eduardo De Santibañes, Ricardo Robles-Campos, Massimo Malagó, Michelle L de Oliveira, Mickael Lesurtel, Pierre-Alain Clavien, Henrik Petrowsky
OBJECTIVE: To longitudinally assess whether risk adjustment in Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) occurred over time and is associated with postoperative outcome. BACKGROUND: ALPPS is a novel 2-stage hepatectomy enabling resection of extensive hepatic tumors. ALPPS has been criticized for its high mortality, which is reported beyond accepted standards in liver surgery. Therefore, adjustments in patient selection and technique have been performed but have not yet been studied over time in relation to outcome...
November 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28798996/operative-results-and-oncologic-outcomes-of-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-alpps-versus-two-stage-hepatectomy-tsh-in-patients-with-unresectable-colorectal-liver-metastases-a-systematic-review-and-meta-analysis
#20
REVIEW
Dimitrios Moris, Sean Ronnekleiv-Kelly, Ioannis D Kostakis, Diamantis I Tsilimigras, Eliza W Beal, Alexandros Papalampros, Dimitrios Dimitroulis, Evangelos Felekouras, Timothy M Pawlik
BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has recently emerged as a treatment choice for patients with colorectal liver metastases (CLM) and inadequate future liver remnant (FLR). The aim of this study was to define the results of ALPPS compared with two-stage hepatectomy (TSH) for patients with CLM. MATERIALS AND METHODS: A meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analysis guidelines...
August 10, 2017: World Journal of Surgery
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