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https://www.readbyqxmd.com/read/29350267/modern-work-up-and-extended-resection-in-perihilar-cholangiocarcinoma-the-amc-experience
#1
REVIEW
F Rassam, E Roos, K P van Lienden, J E van Hooft, H J Klümpen, G van Tienhoven, R J Bennink, M R Engelbrecht, A Schoorlemmer, U H W Beuers, J Verheij, M G Besselink, O R Busch, T M van Gulik
AIM: Perihilar cholangiocarcinoma (PHC) is a challenging disease and requires aggressive surgical treatment in order to achieve curation. The assessment and work-up of patients with presumed PHC is multidisciplinary, complex and requires extensive experience. The aim of this paper is to review current aspects of diagnosis, preoperative work-up and extended resection in patients with PHC from the perspective of our own institutional experience with this complex tumor. METHODS: We provided a review of applied modalities in the diagnosis and work-up of PHC according to current literature...
January 19, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29344520/did-the-international-alpps-meeting-2015-have-an-impact-on-daily-practice-the-hamburg-barmbek-experience-of-58-cases
#2
Gregor A Stavrou, Marcello Donati, Mohammad H Fard-Aghaie, Martin Zeile, Tessa M Huber, Axel Stang, Karl J Oldhafer
Background: ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) was introduced only 10 years ago and has gained wide acceptance as a variation of staged procedures in liver surgery. It has been criticized for its high morbidity and mortality, which all centers reported in their initial series. Methods: After a world expert meeting in Hamburg in 2015 where all experts in the field met to discuss this method, caveats were extracted and formulated...
December 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29344517/a-comparison-of-pitfalls-after-alpps-stage-1-or-portal-vein-embolization-in-small-for-size-setting-hepatectomies
#3
REVIEW
Andreas A Schnitzbauer
Background: Portal vein embolization (PVE) followed by resection and associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) are tools to enable liver resections in small-for-size settings. Methods: A systematic review of the literature and comparison of pitfalls between PVE and resection and after ALPPS stage 1 were performed. Results: Evidence levels were as low as 4 for both procedures. 20 publications were identified with reports on post-PVE or post-ALPPS stage 1 pitfalls...
December 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29344516/hypertrophy-and-liver-function-in-alpps-correlation-with-morbidity-and-mortality
#4
REVIEW
Danby Kang, Erik Schadde
Background: ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) was introduced with the promise to reduce posthepatectomy liver failure (PHLF) in extended hepatectomies but has higher morbidity and mortality rates compared to conventional methods of volume enhancement. There are few studies of the incidence of PHLF after ALPPS and little information on how to avoid PHLF by functional testing. It remains unclear what causes the compromise in liver function despite rapid volume gain and if any of the modifications proposed reduce the incidence of PHLF...
December 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29344513/-in-situ-split-liver-resection-alpps-historical-development-and-current-practice
#5
REVIEW
Hans J Schlitt, Christina Hackl, Sven Arke Lang
Background: Liver tumors that are extensive, multifocal, or critically located frequently require advanced techniques of liver resection including '!' - enabling liver resection in certain situations. Methods: The development of the technique in the first and the subsequent 8 patients in the index center, and also the method's spread throughout Germany and the world were reviewed. Results: In 2007, in the first patient, the new technique was developed intraoperatively by necessity...
December 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29318366/-surgical-innovations-in-treatment-of-metastatic-colorectal-cancer-complexity-of-metastatic-surgery-as-example-for-personalized-medicine
#6
REVIEW
C Hackl, S M Brunner, K M Schmidt, H J Schlitt
BACKGROUND: Extensive, bilobular and multifocal colorectal liver metastases (CLM) or metastases that are critically situated require an experienced surgeon and advanced surgical techniques to enable curative resection. OBJECTIVE: This article describes the toolbox of hepato-oncologic surgery including functional augmentation of liver segments by portal vein embolization/ligation, combinations of ablation and resection, two-stage resections and in situ split liver resection, also known as associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)...
January 9, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29306519/rescue-alpps-after-portal-embolization-for-colorectal-metastases-with-video
#7
C Maulat, B Suc, F Muscari
No abstract text is available yet for this article.
January 3, 2018: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29279592/rapidly-increasing-liver-progenitor-cell-numbers-in-human-regenerating-liver-after-portal-vein-ligation-and-liver-partition
#8
K H Lin, H T Hsu, T H Teng, P Y Lin, C J Ko, C E Hsieh, Y L Chen
BACKGROUND: Liver regeneration is dependent on the proliferation of hepatocytes. Hepatic progenitor cells are intra-hepatic precursor cells capable of differentiating into hepatocytes or biliary cells. Although liver progenitor cell proliferation during the regenerative process has been observed in animal models of severe liver injury, it has never been observed in vivo in humans because it is unethical to take multiple biopsy specimens for the purpose of studying the proliferation of liver progenitor cells and the roles they play in liver regeneration...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29258518/associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-versus-conventional-two-stage-hepatectomy-a-systematic-review-and-meta-analysis
#9
Zheng Zhou, Mingxing Xu, Nan Lin, Chuzhi Pan, Boxuan Zhou, Yuesi Zhong, Ruiyun Xu
BACKGROUND: It is generally accepted that an insufficient future liver remnant is a major limitation of large-scale hepatectomy for patients with primary hepatocellular carcinoma. Conventional two-stage hepatectomy (TSH) is commonly considered to accelerate future liver regeneration despite its low regeneration rate. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), which is characterized by a rapid regeneration, has brought new opportunities. METHODS: Relevant studies were identified by searching the selected databases up to September 2017...
December 19, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29248180/impact-of-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-alpps-on-growth-of-colorectal-liver-metastases
#10
Patryk Kambakamba, Michael Linecker, Marcel Schneider, Cäcilia S Reiner, Thi Dan Linh Nguyen-Kim, Perparim Limani, Ivan Romic, Joan Figueras, Henrik Petrowsky, Pierre-Alain Clavien, Mickaël Lesurtel
BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy induces an unprecedented liver hypertrophy and enables resection of otherwise unresectable liver tumors. The effect of associating liver partition and portal vein ligation for staged hepatectomy on tumor proliferation, however, remains a concern. This study investigated the impact of associating liver partition and portal vein ligation for staged hepatectomy on growth of colorectal metastases in mice and in humans...
December 13, 2017: Surgery
https://www.readbyqxmd.com/read/29239077/high-incidence-of-biliary-stricture-after-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy
#11
Srinivas Sanjeevi, Ernesto Sparrelid, Stefan Gilg, Eduard Jonas, Bengt Isaksson
BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a two-stage procedure most frequently applied in the setting of an extended right-sided hemi-hepatectomy. Initial reports of high mortality have sparked debate regarding the safety and efficacy of the procedure. We describe a higher incidence of early post-operative bile duct strictures after ALPPS, a complication rarely seen after conventional liver resection. METHODS: An institutional review was conducted to assess the incidence of post-operative biliary strictures following conventional right-sided or extended right-sided hemi-hepatectomy and ALPPS...
December 14, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29224266/-application-of-liver-three-dimensional-visualization-technologies-in-the-treatment-planning-of-hepatic-malignant-tumor
#12
P P Li, Z H Wang, G Huang, Z P Huang, Y Li, J S Ni, H Liu, C H Fang, W P Zhou
Objective: To discuss the application of three dimentional(3D)visualization technologies in treatment plan of hepatic malignant tumor. Methods: The clinical data of 300 patients with liver malignant tumor who received treatment from January 2016 to January 2017 in the Third Department of Hepatic Surgery of Eastern Hepatobiliary Surgery Hospital was retrospectively analyzed in this study, including 221 male and 79 female patients aged from 7 to 76 years with median age of 54 years. The median height was 168 cm (115-183 cm), the median weight was 65 kg (20-105 kg) and the median tumor volume was 142 ml (23-2 493 ml)...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29215371/pushing-the-envelope-in-perihiler-cholangiocellularcarcinoma-surgery-tipe-alpps
#13
Deniz Balci
No abstract text is available yet for this article.
February 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29203284/intermediate-term-survival-and-quality-of-life-outcomes-in-patients-with-advanced-colorectal-liver-metastases-undergoing-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy
#14
Kerollos Nashat Wanis, Victoria Ardiles, Fernando A Alvarez, Mauro Enrique Tun-Abraham, David Linehan, Eduardo de Santibañes, Roberto Hernandez-Alejandro
BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is an innovative, 2-staged hepatectomy which has elicited controversy within the international hepatobiliary community. Uptake of ALPPS has been limited due to concerns related to evidence of high morbidity and mortality and scant oncologic and quality of life outcome data and quality of life (Ool). Demonstrating reasonable long-term benefits with a short-term risk is necessary to support more widespread endorsement of ALPPS...
December 1, 2017: Surgery
https://www.readbyqxmd.com/read/29198493/impact-of-associating-liver-partition-and-portal-vein-occlusion-for-staged-hepatectomy-on-tumor-growth-in-a-mouse-model-of-liver-metastasis
#15
Yutaro Kikuchi, Yukihiko Hiroshima, Kenichi Matsuo, Takashi Murakami, Daisuke Kawaguchi, Kohei Kasahara, Kuniya Tanaka
BACKGROUND: The impact of associating liver partition and portal vein occlusion for staged hepatectomy (ALPPS) on tumor growth activity was investigated. METHODS: A BALB/c mouse model (male, 8-10 weeks old) of liver metastasis labeled by red fluorescent protein was established. Changes in future liver remnant (FLR) volumes, tumor growth activity, and levels of cytokines and growth factors in liver tissues during the treatment period were compared among the models involving ALPPS, portal vein ligation (PVL), or sham operation...
November 23, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29173259/optimizing-associated-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-outcomes-surgical-experience-or-appropriate-patient-selection
#16
COMPARATIVE STUDY
Ibrahim Al Hasan, Mauro Enrique Tun-Abraham, Kerollos N Wanis, Carlos Garcia-Ochoa, Mark A Levstik, Bandar Al-Judaibi, Roberto Hernandez-Alejandro
BACKGROUND: Early reports of associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) outcomes have been suboptimal. The literature has confirmed that learning curves influence surgical outcomes. We have 54 months of continuous experience performing ALPPS with strict selection criteria. This study aimed to evaluate the impact of the learning curve on ALPPS outcomes. METHODS: We retrospectively compared patients who underwent ALPPS between April 2012 and March 2016...
December 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/29137004/the-principle-of-preserving-outflow-structures-in-partial-alpps-a-commentary-on-segment-4-a-key-point-of-alpps-procedure
#17
LETTER
Henrik Petrowsky, Pierre-Alain Clavien
No abstract text is available yet for this article.
December 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29137003/segment-4-a-key-point-of-alpps-procedure
#18
Giuseppe Maria Ettorre, Nicola Guglielmo, Roberto Luca Meniconi, Giovanni Battista Levi Sandri, Marco Colasanti, Giovanni Vennarecci
No abstract text is available yet for this article.
December 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29136967/are-we-ready-to-perform-fully-minimally-invasive-alpps
#19
Giovanni Battista Levi Sandri, Francesco Guerra
No abstract text is available yet for this article.
December 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29046476/tracking-mesenchymal-stem-cell-contributions-to-regeneration-in-an-immunocompetent-cartilage-regeneration-model
#20
Daniela Zwolanek, María Satué, Verena Proell, José R Godoy, Kathrin I Odörfer, Magdalena Flicker, Sigrid C Hoffmann, Thomas Rülicke, Reinhold G Erben
It is currently controversially discussed whether mesenchymal stem cells (MSC) facilitate cartilage regeneration in vivo by a progenitor- or a nonprogenitor-mediated mechanism. Here, we describe a potentially novel unbiased in vivo cell tracking system based on transgenic donor and corresponding immunocompetent marker-tolerant recipient mouse and rat lines in inbred genetic backgrounds. Tolerance of recipients was achieved by transgenic expression of an immunologically neutral but physicochemically distinguishable variant of the marker human placental alkaline phosphatase (ALPP)...
October 19, 2017: JCI Insight
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