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https://www.readbyqxmd.com/read/28288067/modified-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-for-hepatoblastoma-in-a-small-infant-how-far-can-we-push-the-envelope
#1
Johnny C Hong, Joohyun Kim, Meghen Browning, Amy Wagner, Stacee Lerret, Annette D Segura, Michael A Zimmerman
For patients with hepatoblastoma, a timely and complete resection of the tumor is critical to the patient's tumor recurrence-free survival. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), a 2-stage hepatectomy procedure, has revolutionized the surgical management of large hepatic tumors with insufficient future liver remnant (FLR) at presentation. Although existing data support the utility of ALPPS in adults with primary and metastatic hepatobiliary malignancy, the literature in children is scarce...
March 10, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28288058/hybrid-partial-alpps-a-feasible-approach-in-case-of-right-trisegmentectomy-and-macrovascular-invasion
#2
Quirino Lai, Fabio Melandro, Massimo Rossi
No abstract text is available yet for this article.
March 10, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28288054/reply-to-letter-minimize-the-surgical-damage-at-the-stage-1-operation-by-combining-hybrid-alpps-and-nontotal-parenchymal-transection
#3
Jun Li, Bjoern Nashan
No abstract text is available yet for this article.
March 10, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28283924/dynamic-evaluation-of-liver-volume-and-function-in-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy
#4
Ernesto Sparrelid, Eduard Jonas, Antonios Tzortzakakis, Ulrika Dahlén, Gustav Murquist, Torkel Brismar, Rimma Axelsson, Bengt Isaksson
BACKGROUND: Despite a fast and potent growth of the future liver remnant (FLR), patients operated with associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) are at risk of developing posthepatectomy liver failure. In this study, the relation between liver volume and function in ALPPS was studied using a multimodal assessment. METHODS: Nine patients with colorectal liver metastases treated with neoadjuvant chemotherapy and operated with ALPPS were studied with hepatobiliary scintigraphy, computed tomography, indocyanine green clearance test, and serum liver function tests...
March 10, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28281692/ibuprofen-results-in-alterations-of-human-fetal-testis-development
#5
Millissia Ben Maamar, Laurianne Lesné, Kristin Hennig, Christèle Desdoits-Lethimonier, Karen R Kilcoyne, Isabelle Coiffec, Antoine D Rolland, Cécile Chevrier, David M Kristensen, Vincent Lavoué, Jean-Philippe Antignac, Bruno Le Bizec, Nathalie Dejucq-Rainsford, Rod T Mitchell, Séverine Mazaud-Guittot, Bernard Jégou
Among pregnant women ibuprofen is one of the most frequently used pharmaceutical compounds with up to 28% reporting use. Regardless of this, it remains unknown whether ibuprofen could act as an endocrine disruptor as reported for fellow analgesics paracetamol and aspirin. To investigate this, we exposed human fetal testes (7-17 gestational weeks (GW)) to ibuprofen using ex vivo culture and xenograft systems. Ibuprofen suppressed testosterone and Leydig cell hormone INSL3 during culture of 8-9 GW fetal testes with concomitant reduction in expression of the steroidogenic enzymes CYP11A1, CYP17A1 and HSD17B3, and of INSL3...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28279621/high-mortality-after-alpps-for-perihilar-cholangiocarcinoma-case-control-analysis-including-the-first-series-from-the-international-alpps-registry
#6
Pim B Olthof, Robert J S Coelen, Jimme K Wiggers, Bas Groot Koerkamp, Massimo Malago, Roberto Hernandez-Alejandro, Stefan A Topp, Marco Vivarelli, Luca A Aldrighetti, Ricardo Robles Campos, Karl J Oldhafer, William R Jarnagin, Thomas M van Gulik
INTRODUCTION: Resection of perihilar cholangiocarcinoma (PHC) entails high-risk surgery with postoperative mortality reported up to 18%, even in specialized centers. The aim of this study was to compare outcomes of PHC patients who underwent associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) to patients who underwent resection without ALPPS. METHODS: All patients who underwent ALPPS for PHC were identified from the international ALPPS registry and matched controls were selected from a standard resection cohort from two centers based on future remnant liver size...
March 6, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28273656/animal-models-for-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-alpps-achievements-and-future-perspectives
#7
Andras Budai, Andras Fulop, Oszkar Hahn, Peter Onody, Tibor Kovacs, Tibor Nemeth, Miklos Dunay, Attila Szijarto
BACKGROUND: Since 2012, Associated Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has been standing in the limelight of modern liver surgery and numerous questions have been raised regarding this novel approach. On the one hand, ALPPS has proved to be a valuable method in the treatment of hepatic tumors, while on the other hand, there are many controversies, such as high mortality and morbidity rates. Further surgical research is essential for a better understanding of underlying mechanisms and for enhancing patient safety...
March 9, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28270160/alpps-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-does-not-affect-proliferation-apoptosis-or-angiogenesis-as-compared-to-standard-liver-resection-for-colorectal-liver-metastases
#8
Katharina Joechle, Christian Moser, Petra Ruemmele, Katharina M Schmidt, Jens M Werner, Edward K Geissler, Hans J Schlitt, Sven A Lang
BACKGROUND: ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) is a novel two-stage strategy to induce rapid hypertrophy of the future liver remnant (FLR) when patients are in danger of postoperative liver failure due to insufficient FLR. However, the effects of ALPPS on colorectal liver metastases (CRLM) are not clear so far. The aim of our study was to determine whether ALPPS induces proliferation, apoptosis, or vascularization compared to standard (one-stage) liver resection...
March 7, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28267203/expanding-the-limits-of-resectability-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-alpps-using-monosegment-6-facilitated-by-an-inferior-right-hepatic-vein
#9
Karen Pineda-Solís, Dave Paskar, Mauro Tun-Abraham, Roberto Hernandez-Alejandro
We describe our technique using the combination of a recent surgical technique (ALPPS) and an anomalous vascular anatomy to push the current limits of liver resectability. The approach allowed the resection of the three hepatic veins and preserved a peripheral segment 6 as the only future liver remnant, having an inferior hepatic vein as its outflow.
March 7, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28266972/laparoscopy-in-alpps-procedure-when-we-can-do-it
#10
Pablo Barros Schelotto, Gabriel Gondolesi
No abstract text is available yet for this article.
April 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28191866/laparoscopic-liver-resection-a-review-of-current-status
#11
Yihe Yan, Xiaoyong Cai, David A Geller
BACKGROUND: Laparoscopic liver resection (LLR) has been increasing since it was first reported in 1991. Two international expert consensus conferences on LLR surgery were held in Louisville, KY, USA, in 2008 and in Morioka, Japan, in 2014, respectively. While most initial minimally invasive liver resections were typically done for benign lesions in anterior or left lateral segments, LLR is currently being applied for major anatomic resections, malignancy, cirrhosis, and live donor hepatectomy...
February 13, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28159501/totally-laparoscopic-alpps-for-multiple-and-bilobar-colorectal-metastases-with-video
#12
M-A Machado, R-C Surjan, T Bassères, F-F Makdissi
No abstract text is available yet for this article.
January 31, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28154774/portal-vein-embolization-for-induction-of-selective-hepatic-hypertrophy-prior-to-major-hepatectomy-rationale-techniques-outcomes-and-future-directions
#13
David Li, David C Madoff
The ability to modulate the future liver remnant (FLR) is a key component of modern oncologic hepatobiliary surgery practice and has extended surgical candidacy for patients who may have been previously thought unable to survive liver resection. Multiple techniques have been developed to augment the FLR including portal vein embolization (PVE), associating liver partition and portal vein ligation (ALPPS), and the recently reported transhepatic liver venous deprivation (LVD). PVE is a well-established means to improve the safety of liver resection by redirecting blood flow to the FLR in an effort to selectively hypertrophy and ultimately improve functional reserve of the FLR...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28126206/conversion-to-segment-4-1-alpps-associated-with-right-bile-duct-section-and-external-tube-for-the-control-of-progression-through-the-bile-duct-of-colorectal-metastases
#14
Oscar Alonso Casado, Gloria Ortega Pérez, Sara Encinas García, Raquel Saiz Martínez, Santiago González Moreno
No abstract text is available yet for this article.
January 23, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28121683/interstage-assessment-of-remnant-liver-function-in-alpps-using-hepatobiliary-scintigraphy-prediction-of-posthepatectomy-liver-failure-and-introduction-of-the-hiba-index
#15
Matteo Serenari, Carlos Collaud, Fernando A Alvarez, Martin de Santibañes, Diego Giunta, Juan Pekolj, Victoria Ardiles, Eduardo de Santibañes
OBJECTIVE: The aim of this study was to evaluate interstage liver function in associating liver partition and portal vein occlusion for staged hepatectomy (ALPPS) using hepatobiliary scintigraphy (HBS) and whether this may help to predict posthepatectomy liver failure (PHLF). BACKGROUND: ALPPS remains controversial given the high rate of liver-related mortality after stage 2. HBS combined with single photon emission computed tomography (SPECT) accurately estimates future liver remnant function and may be useful to predict PHLF...
January 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28119254/associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-the-current-role-and-development
#16
Wan Yee Lau, Eric Ch Lai, Stephanie Hy Lau
BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has recently been developed to induce rapid liver hypertrophy and reduce post-hepatectomy liver failure in patients with insufficient future liver remnant (FLR). ALPPS is still considered to be in an early developmental phase because surgical indications and techniques have not been standardized. This article aimed to review the current role and future developments of ALPPS. DATA SOURCES: Studies were identified by searching MEDLINE and PubMed for articles from January 2007 to October 2016 using the keywords "associating liver partition and portal vein ligation for staged hepatectomy" and "ALPPS"...
February 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28115945/isolation-and-characterization-of-synovial-mesenchymal-stem-cell-derived-from-hip-joints-a-comparative-analysis-with-a-matched-control-knee-group
#17
Akihisa Hatakeyama, Soshi Uchida, Hajime Utsunomiya, Manabu Tsukamoto, Hirotaka Nakashima, Eiichiro Nakamura, Cecilia Pascual-Garrido, Ichiro Sekiya, Akinori Sakai
Purpose. To determine the characteristics of MSCs from hip and compare them to MSCs from knee. Methods. Synovial tissues were obtained from both the knee and the hip joints in 8 patients who underwent both hip and knee arthroscopies on the same day. MSCs were isolated from the knee and hip synovial samples. The capacities of MSCs were compared between both groups. Results. The number of cells per unit weight at passage 0 of synovium from the knee was significantly higher than that from the hip (P < 0.05)...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28059974/modified-alpps-procedures-avoiding-division-of-portal-pedicles
#18
Ricardo Robles-Campos, Roberto Brusadin, Asunción López-Conesa, Pascual Parrilla
No abstract text is available yet for this article.
February 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28038862/survival-after-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-alpps-for-advanced-colorectal-liver-metastases-a-case-matched-comparison-with-palliative-systemic-therapy
#19
Pim B Olthof, Joost Huiskens, Dennis A Wicherts, Pablo E Huespe, Victoria Ardiles, Ricardo Robles-Campos, René Adam, Michael Linecker, Pierre-Alain Clavien, Miriam Koopman, Cornelis Verhoef, Cornelis J A Punt, Thomas M van Gulik, Eduardo de Santibanes
BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) allows the resection of colorectal liver metastases with curative intent which would otherwise be unresectable and only eligible for palliative systemic therapy. This study aimed to compare outcomes of ALPPS in patients with otherwise unresectable colorectal liver metastases with matched historic controls treated with palliative systemic treatment. METHODS: All patients with colorectal liver metastases from the international ALPPS registry were identified and analyzed...
December 27, 2016: Surgery
https://www.readbyqxmd.com/read/28032566/rabbit-model-provides-new-insights-in-liver-regeneration-after-transection-with-portal-vein-ligation
#20
Mingheng Liao, Tao Zhang, Haichuan Wang, Ying Liu, Minxun Lu, Jiwei Huang, Yong Zeng
BACKGROUND: The rabbit model of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has not been reported before. MATERIALS AND METHODS: New Zealand white rabbits were allocated to two protocols. Protocol 1 involved either liver parenchymal transection (LPT, n = 5) or portal vein ligation (PVL, n = 5). Protocol 2 involved the ligation of different portal vein branches combined with liver partition, including the LPT + 20% PVL group (n = 5; the caudate portal vein was ligated), the LPT + 50% PVL group (n = 5; the left portal vein was ligated), and the LPT + 70% PVL group (n = 10; both veins were ligated)...
November 2, 2016: Journal of Surgical Research
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