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Pregnancy infection

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https://www.readbyqxmd.com/read/28546324/risk-factors-for-pregnancy-associated-stroke-in-women-with-preeclampsia
#1
Eliza C Miller, Hajere J Gatollari, Gloria Too, Amelia K Boehme, Lisa Leffert, Randolph S Marshall, Mitchell S V Elkind, Joshua Z Willey
BACKGROUND AND PURPOSE: Preeclampsia affects 3% to 8% of pregnancies and increases risk of pregnancy-associated stroke (PAS). Data are limited on which women with preeclampsia are at highest risk for PAS. METHODS: Using billing data from the 2003 to 2012 New York State Department of Health inpatient database, we matched women with preeclampsia and PAS 1:3 to preeclamptic controls based on age and race/ethnicity. Pre-defined PAS risk factors included pregnancy complications, infection present on admission, vascular risk factors, prothrombotic states, and coagulopathies...
May 25, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28545476/prenatal-diagnosis-and-prevention-of-toxoplasmosis-in-pregnant-women-in-northern-vietnam-study-protocol
#2
G Suzanne A Smit, Thi Lam Binh Vu, Trung Dung Do, Niko Speybroeck, Brecht Devleesschauwer, Elizaveta Padalko, Ellen Roets, Pierre Dorny
BACKGROUND: In Vietnam, no systematic prenatal toxoplasmosis screening is in place, and only few studies have assessed the prevalence and importance of this zoonotic parasite infection. In addition, no studies have been conducted to assess the risk factors associated with toxoplasmosis. This study protocol was developed to determine the seroprevalence of toxoplasmosis in pregnant women in Hanoi and Thai Binh, Northern Vietnam, and to evaluate the association with risk factors and congenital toxoplasmosis...
May 25, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28543426/predictors-and-pathways-of-language-and-motor-development-in-four-prospective-cohorts-of-young-children-in-ghana-malawi-and-burkina-faso
#3
Elizabeth L Prado, Souheila Abbeddou, Seth Adu-Afarwuah, Mary Arimond, Per Ashorn, Ulla Ashorn, Jaden Bendabenda, Kenneth H Brown, Sonja Y Hess, Emma Kortekangas, Anna Lartey, Kenneth Maleta, Brietta M Oaks, Eugenia Ocansey, Harriet Okronipa, Jean Bosco Ouédraogo, Anna Pulakka, Jérôme W Somé, Christine P Stewart, Robert C Stewart, Stephen A Vosti, Elizabeth Yakes Jimenez, Kathryn G Dewey
BACKGROUND: Previous reviews have identified 44 risk factors for poor early child development (ECD) in low- and middle-income countries. Further understanding of their relative influence and pathways is needed to inform the design of interventions targeting ECD. METHODS: We conducted path analyses of factors associated with 18-month language and motor development in four prospective cohorts of children who participated in trials conducted as part of the International Lipid-Based Nutrient Supplements (iLiNS) Project in Ghana (n = 1,023), Malawi (n = 675 and 1,385), and Burkina Faso (n = 1,122)...
May 23, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28542585/highly-efficient-maternal-fetal-zika-virus-transmission-in-pregnant-rhesus-macaques
#4
Sydney M Nguyen, Kathleen M Antony, Dawn M Dudley, Sarah Kohn, Heather A Simmons, Bryce Wolfe, M Shahriar Salamat, Leandro B C Teixeira, Gregory J Wiepz, Troy H Thoong, Matthew T Aliota, Andrea M Weiler, Gabrielle L Barry, Kim L Weisgrau, Logan J Vosler, Mariel S Mohns, Meghan E Breitbach, Laurel M Stewart, Mustafa N Rasheed, Christina M Newman, Michael E Graham, Oliver E Wieben, Patrick A Turski, Kevin M Johnson, Jennifer Post, Jennifer M Hayes, Nancy Schultz-Darken, Michele L Schotzko, Josh A Eudailey, Sallie R Permar, Eva G Rakasz, Emma L Mohr, Saverio Capuano, Alice F Tarantal, Jorge E Osorio, Shelby L O'Connor, Thomas C Friedrich, David H O'Connor, Thaddeus G Golos
Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report clear viremia within 10-12 days, maternal viremia was prolonged in 3 of 4 pregnancies. Fetal head growth velocity in the last month of gestation determined by ultrasound assessment of head circumference was decreased in comparison with biparietal diameter and femur length within each fetus, both within normal range...
May 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28542391/effectiveness-of-facility-based-personalized-maternal-nutrition-counseling-in-improving-child-growth-and-morbidity-up-to-18-months-a-cluster-randomized-controlled-trial-in-rural-burkina-faso
#5
Laetitia Nikièma, Lieven Huybregts, Yves Martin-Prevel, Philippe Donnen, Hermann Lanou, Joep Grosemans, Priscilla Offoh, Michèle Dramaix-Wilmet, Blaise Sondo, Dominique Roberfroid, Patrick Kolsteren
The period from conception to 24 months of age is a crucial window for nutrition interventions. Personalized maternal counseling may improve childbirth outcomes, growth, and health. We assessed the effectiveness of facility-based personalized maternal nutrition counseling (from pregnancy to 18 months after birth) in improving child growth and health in rural Burkina Faso. We conducted a paired cluster randomized controlled trial in a rural district of Burkina Faso with 12 primary health centers (clusters). Healthcare providers in the intervention centers received patient-centered communication and nutrition counseling training...
2017: PloS One
https://www.readbyqxmd.com/read/28542366/illicit-drug-use-and-its-association-with-key-sexual-risk-behaviours-and-outcomes-findings-from-britain-s-third-national-survey-of-sexual-attitudes-and-lifestyles-natsal-3
#6
Rachelle Paquette, Clare Tanton, Fiona Burns, Philip Prah, Maryam Shahmanesh, Nigel Field, Wendy Macdowall, Kirsten Gravningen, Pam Sonnenberg, Catherine H Mercer
OBJECTIVES: We explore the hypothesis that using illicit drugs other than, or in addition to, cannabis is associated with sexual risk behaviour and sexual health outcomes in the British population. METHODS: We analysed data, separately by gender, reported by sexually-active participants (those reporting > = 1 partners/past year) aged 16-44 years (3,395 men, 4,980 women) in Britain's third National Survey of Sexual Attitudes and Lifestyles (Natsal-3), a probability survey undertaken 2010-12 involving computer-assisted personal-interview and computer-assisted self-interview...
2017: PloS One
https://www.readbyqxmd.com/read/28542081/dapivirine-vaginal-ring-use-does-not-diminish-the-effectiveness-of-hormonal-contraception
#7
Jennifer E Balkus, Thesla Palanee-Phillips, Krishnaveni Reddy, Samantha Siva, Ishana Harkoo, Clemensia Nakabiito, Kenneth Kintu, Gonasangrie Nair, Catherine Chappell, Flavia Matovu Kiweewa, Samuel Kabwigu, Logashvari Naidoo, Nitesha Jeenarain, Mark Marzinke, Lydia Soto-Torres, Elizabeth R Brown, Jared M Baeten
OBJECTIVE: To evaluate the potential for a clinically relevant drug-drug interaction with concomitant use of a dapivirine vaginal ring, a novel antiretroviral-based HIV-1 prevention strategy, and hormonal contraception by examining contraceptive efficacies with and without dapivirine ring use. DESIGN: A secondary analysis of women participating in MTN-020/ASPIRE, a randomized, double-blind, placebo-controlled trial of the dapivirine vaginal ring for HIV-1 prevention...
May 23, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28540262/inactive-hepatitis-b-carrier-and-pregnancy-outcomes-a-systematic-review-and-meta-analysis
#8
REVIEW
Afsaneh Keramat, Masud Younesian, Mohammad Gholami Fesharaki, Maryam Hasani, Samaneh Mirzaei, Elham Ebrahimi, Seyed Moaed Alavian, Fatemeh Mohammadi
BACKGROUND: We aimed to explore whether maternal asymptomatic hepatitis B (HB) infection effects on pre-term rupture of membranous (PROM), stillbirth, preeclampsia, eclampsia, gestational hypertension, or antepartum hemorrhage. METHODS: We searched the PubMed, Scopus, and ISI web of science from 1990 to Feb 2015. In addition, electronic literature searches supplemented by searching the gray literature (e.g., conference abstracts thesis and the result of technical reports) and scanning the reference lists of included studies and relevant systematic reviews...
April 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28539867/prevalence-of-periodontal-disease-its-association-with-systemic-diseases-and-prevention
#9
REVIEW
Muhammad Ashraf Nazir
Periodontal diseases are prevalent both in developed and developing countries and affect about 20-50% of global population. High prevalence of periodontal disease in adolescents, adults, and older individuals makes it a public health concern. Several risk factors such as smoking, poor oral hygiene, diabetes, medication, age, hereditary, and stress are related to periodontal diseases. Robust evidence shows the association of periodontal diseases with systemic diseases such as cardiovascular disease, diabetes, and adverse pregnancy outcomes...
April 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28539842/a-review-of-antiviral-use-for-the-treatment-of-chronic-hepatitis-b-virus-infection-in-pregnant-women
#10
Ariel Jaffe, Robert S Brown
Mother-to-child transmission (MTCT) of hepatitis B virus (HBV) remains high even with the proper use of active-passive immunoprophylaxis in newborns. Mothers with significant viremia are at a much higher risk of MTCT; therefore, treatments aimed at lowering HBV DNA levels during pregnancy may ultimately decrease global disease burden. The exact threshold for treatment remains controversial; however, most studies have accepted levels greater than 2 × 5 log10 IU/mL as significant viremia. We reviewed the most recent literature on antiviral efficacy, maternal and fetal safety, and viral resistance patterns when used for short-duration therapy in pregnancy...
March 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28539446/infectious-prions-in-the-pregnancy-microenvironment-of-cwd-infected-reeves-muntjac-deer
#11
Amy V Nalls, Erin McNulty, Clare E Hoover, Laura A Pulscher, Edward A Hoover, Candace K Mathiason
Ample evidence exists for the presence of infectious agents at the maternal-fetal interface, often with grave outcomes to the developing fetus (i.e. zika virus, brucella, cytomegalovirus, toxoplasma). While less studied, pregnancy-related transmissible spongiform encephalopathies (TSEs) have been implicated in several species, including humans. Our previous work has shown that prions can be transferred from mother-to-offspring resulting in the development of clinical TSE disease in offspring born to CWD-infected muntjac dams (64)...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28536957/brief-report-association-between-autism-spectrum-disorder-gastrointestinal-problems-and-perinatal-risk-factors-within-sibling-pairs
#12
Johan Isaksson, Erik Pettersson, Elzbieta Kostrzewa, Rochellys Diaz Heijtz, Sven Bölte
Autism spectrum disorder (ASD) has been associated with gastrointestinal (GI) problems, but the nature of this association is unclear. Parents to siblings, concordant or discordant for ASD (N = 217), participated in a web survey covering mother's weight gain during pregnancy, maternal viral/bacterial infection and use of antibiotics, duration of breastfeeding, mode of delivery, birth weight and child GI problems. ASD was associated with GI problems and perinatal environmental risk, based on a summation of maternal infection and antibiotic use during pregnancy and/or the breastfeeding period...
May 23, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28536811/listeriosis-during-pregnancy
#13
REVIEW
Mitko Madjunkov, Shahnaz Chaudhry, Shinya Ito
PURPOSE: Listeriosis is a rare foodborne illness caused by Listeria monocytogenes. It can be transmitted by consuming contaminated ready-to-eat food, long shelf-life products, deli meats, and soft cheeses. Listeria has a predilection to affect immunocompromised patients, elderly people, pregnant women and neonates. In particular, pregnant women are at ~18 times greater risk of infection than general population due to specific pregnancy-related suppressed cell-mediated immunity and placental tropism of L...
May 23, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28536443/diagnostic-accuracy-of-ultrasound-scanning-for-prenatal-microcephaly-in-the-context-of-zika-virus-infection-a-systematic-review-and-meta-analysis
#14
Ezinne C Chibueze, Alex J Q Parsons, Katharina da Silva Lopes, Takemoto Yo, Toshiyuki Swa, Chie Nagata, Nobuyuki Horita, Naho Morisaki, Olukunmi O Balogun, Amarjargal Dagvadorj, Erika Ota, Rintaro Mori, Olufemi T Oladapo
To assess the accuracy of ultrasound measurements of fetal biometric parameters for prenatal diagnosis of microcephaly in the context of Zika virus (ZIKV) infection, we searched bibliographic databases for studies published until March 3rd, 2016. We extracted the numbers of true positives, false positives, true negatives, and false negatives and performed a meta-analysis to estimate group sensitivity and specificity. Predictive values for ZIKV-infected pregnancies were extrapolated from those obtained for pregnancies unrelated to ZIKV...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28535868/helicobacter-infection-significantly-alters-pregnancy-success-in-laboratory-mice
#15
Tara C Bracken, Caitlin A Cooper, Zil Ali, Ha Truong, Julie M Moore
Helicobacter spp. are gram-negative, helically shaped bacteria that cause gastric and enterohepatic infections in mammalian species. Although Helicobacter infection frequently is implicated to interfere with reproductive success, few experimental data support these claims. We therefore retrospectively investigated the effect of Helicobacter infection on murine pregnancy outcome after the identification of endemic Helicobacter infection in an animal research facility. Multiplex conventional PCR analysis was used to characterize Helicobacter infection status in one inbred and 2 transgenic strains of mice in 2 self-contained rooms assigned to the same investigator...
May 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28535404/placental-inflammation-and-its-relationship-to-cervicovaginal-fetal-fibronectin-in-preterm-birth
#16
Laura van der Krogt, Alexandra E Ridout, Paul T Seed, Andrew H Shennan
OBJECTIVE: Late miscarriage and preterm birth are frequently thought to be associated with inflammation and infection, although in most cases the underlying cause of early delivery remains unknown. The placenta is the organ that links mother and fetus during pregnancy, and postnatal examination may provide useful information about pathophysiology. The relationship between placental pathological lesions and predictive markers of early delivery has not been explored. We sought to characterize preterm deliveries according to placental pathology and relate these to the performance of reliable predictive markers, fetal fibronectin and cervical length...
May 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28535184/maternal-zika-virus-disease-severity-virus-load-prior-dengue-antibodies-and-their-relationship-to-birth-outcomes
#17
U A Halai, K Nielsen-Saines, M E Moreira, P C Sequeira, J P Pereira Junior, A A Zin, J D Cherry, C R Gabaglia, S L Gaw, K Adachi, I Tsui, J H Pilotto, R M Ribeiro Nogueira, A M Bispo de Filippis, P Brasil
Background: Congenital Zika virus (ZIKV) syndrome is a newly identified condition resulting from infection during pregnancy. We analyzed outcome data from a mother-infant cohort in Rio de Janeiro in order to assess whether clinical severity of maternal ZIKV infection was associated with maternal virus load, prior dengue antibodies or abnormal pregnancy/infant outcomes. Methods: A clinical severity assessment tool was developed based on duration of fever, severity of rash, multisystem involvement and duration of symptoms during ZIKV infection...
May 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28534010/autophagy-in-the-placenta
#18
REVIEW
Soo-Young Oh, Cheong-Rae Roh
Autophagy is an evolutionarily conserved catalytic process by which cytoplasmic components including damaged macromolecules and organelles are degraded. The role of autophagy includes adaptive responses to nutrition deprivation or intracellular stimuli. Although autophagosomes were first observed in early 1960s, it was 1990s that autophagy-related genes in yeast were identified and studied. Nowadays, the molecular machinery of autophagy and signaling pathway to various stimuli are almost outlined. Dysregulation of autophagic activity has been implicated in many human diseases including neurodegenerative diseases, infection and inflammation, and malignancies...
May 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28532649/condom-availability-in-schools-a-practical-approach-to-the-prevention-of-sexually-transmitted-infection-hiv-and-unintended-pregnancy
#19
(no author information available yet)
Adolescents and young adults are highly impacted by sexually transmitted infections (STIs) and unplanned pregnancy in the United States and globally. Consistent and correct use of male latex condoms is associated with protection against both STIs and pregnancy. Providing adolescents and young adults with access to free condoms in schools may increase the use of condoms by improving condom availability, eliminating cost, and decreasing embarrassment associated with purchasing condoms. Studies demonstrate that condom availability in schools is associated with the increased use of condoms and improved overall sexual health...
June 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28528802/symptomatic-dengue-infection-during-pregnancy-and-livebirth-outcomes-in-brazil-2007-13-a-retrospective-observational-cohort-study
#20
Laura B Nascimento, Cláudio M Siqueira, Giovanini E Coelho, João B Siqueira
BACKGROUND: Dengue is a major public health challenge in Brazil. We assessed the relationship between symptomatic dengue infection during pregnancy and adverse birth outcomes in the country between 2007 and 2013. METHODS: We did a retrospective observational cohort study using information reported in the Brazilian national reportable disease information system (SINAN) and the livebirth information system (SINASC) databases. We probabilistically linked confirmed dengue-positive and dengue-negative pregnancies with live childbirths using Fine-Grained Record Integration and Linkage (FRIL) software...
May 18, 2017: Lancet Infectious Diseases
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