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https://www.readbyqxmd.com/read/29778409/extensive-periosteal-new-bone-formation-in-a-skeleton-from-post-medieval-chichester-england-a-probable-case-of-metastatic-prostatic-carcinoma
#1
Carolyn Rando, Tony Waldron
An elderly male skeleton from a site in Chichester, UK, was found with a widespread periosteal reaction, principally affecting the axial skeleton and the pelvis. Radiography showed the presence of sclerosing infiltrates, mainly involving the lumbar vertebrae and pelvis. The differential diagnosis is discussed, reaching the conclusion that hypertrophic osteo-arthopathy (HOA) is the only reasonable alternative condition likely to produce such a widespread periosteal reaction as found here. HOA does not produce secondary deposits in the skeleton, however, and we conclude that his is most likely a case of prostatic carcinoma...
July 29, 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29775162/validation-of-prone-intraoperative-measurements-of-global-spinal-alignment
#2
Max Vaynrub, Brandon P Hirsch, Jared Tishelman, Dennis Vasquez-Montes, Aaron J Buckland, Thomas J Errico, Themistocles S Protopsaltis
OBJECTIVE Verifying the adequacy of surgical correction of adult spinal sagittal deformity (SSD) leads to improved postoperative alignment and clinical outcomes. Traditionally, surgeons relied on intraoperative measurements of lumbar lordosis (LL) correction. However, T-1 pelvic angle (TPA) and its component angles more reliably predict postoperative alignment. While TPA is readily measured on standing radiographs, intraoperative radiographs offer poor resolution of the bicoxofemoral axis. A method to recreate this radiographic landmark by extrapolating preoperative measurements has been described...
May 18, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29774581/association-of-polymorphisms-in-nr6a1-plag1-and-vrtn-with-the-number-of-vertebrae-in-chinese-tongcheng-%C3%A3-large-white-crossbred-pigs
#3
Yu Zhang, Meng Wang, Jiao Yuan, Xiang Zhou, Sanping Xu, Bang Liu
No abstract text is available yet for this article.
May 18, 2018: Animal Genetics
https://www.readbyqxmd.com/read/29774412/hybrid-constructs-pedicle-screw-with-apical-sublaminar-bands-versus-pedicle-screws-only-for-surgical-correction-of-adolescent-idiopathic-scoliosis
#4
Matteo Palmisani, Eugenio Dema, Stefano Cervellati, Rosa Palmisani
PURPOSE: To compare the 2-year minimum postoperative results of posterior correction and spinal arthrodesis using translational correction with hybrid (sublaminar bands on concave side and pedicle screw) constructs versus correction with intermediate density pedicle screw-only constructs in the treatment of AIS (Lenke 1). METHODS: A total of 37 patients with AIS at single institutions who underwent posterior spinal arthrodesis pedicle screw with sublaminar bands at the apex (19 patients) (Group A) or pedicle screw-only (18) constructs (Group B) were selected and matched according to similar age at surgery 13...
May 17, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29773673/lysosomal-proteome-and-secretome-analysis-identifies-missorted-enzymes-and-their-non-degraded-substrates-in-mucolipidosis-iii-mouse-cells
#5
Giorgia Di Lorenzo, Renata Voltolini Velho, Dominic Winter, Melanie Thelen, Shiva Ahmadi, Michaela Schweizer, Raffaella De Pace, Kerstin Cornils, Timur Alexander Yorgan, Saskia Grüb, Irm Hermans-Borgmeyer, Thorsten Schinke, Sven Müller-Loennies, Thomas Braulke, Sandra Pohl
Targeting of soluble lysosomal enzymes requires mannose 6-phosphate (M6P) signals whose formation is initiated by the hexameric N-acetylglucosamine (GlcNAc)-1-phosphotransferase complex (α2β2γ2). Upon proteolytic cleavage by site-1 protease, the α/β-subunit precursor is catalytically activated but the functions of γ-subunits (Gnptg) in M6P modification of lysosomal enzymes are unknown. To investigate this, we analyzed the Gnptg expression in mouse tissues, primary cultured cells, and in Gnptg reporter mice in vivo, and found high amounts in the brain, eye, kidney, femur, vertebra and fibroblasts...
May 17, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29773568/radiation-induced-myelitis-initial-and-follow-up-mri-and-clinical-features-in-patients-at-a-single-tertiary-care-institution-during-20-years
#6
M Khan, P Ambady, D Kimbrough, T Shoemaker, S Terezakis, J Blakeley, S D Newsome, I Izbudak
Myelitis is a rare complication of radiation exposure to the spinal cord and is often a diagnosis of exclusion. A retrospective review of clinical records and serial imaging was performed to identify subjects with documented myelitis and a history of prior radiation. Eleven patients fulfilled the inclusion criteria. All patients had longitudinally extensive cord involvement with homogeneous precontrast T1 hyperintense signal in the adjacent vertebrae, corresponding to the radiation field. T2 signal abnormalities involving the central two-thirds of the cord were seen in 6/11 patients (55%)...
May 17, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29772858/-observation-of-clinical-effects-of-percutaneous-vertebroplasty-in-the-treatment-of-vertebral-compression-fractures-complicated-with-intravertebral-clefts
#7
Lei Duan, Guang-Chuan Yang, Wei-Zhong Tang, Jun Zheng
OBJECTIVE: To explore the clinical effects of percutaneous vertebroplasty(PVP)in the treatment of osteoporotic vertebral compression fractures complicated with intravertebral clefts. METHODS: The clinical data of 176 patients with osteoporotic vertebral compression fractures underwent treatment from January 2013 to May 2016 were retrospectively analyzed. All the patients were treated by unilateral PVP procedure, 37 patients with intravertebral clefts. Seven cases were excluded according to the standard and 30 patients were internalized in the study...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29772857/-posterior-spinal-canal-decompression-with-screw-fixation-and-reconstruction-of-three-vertebral-column-for-thoracolumbar-burst-fractures-complicated-with-nerve-injury
#8
Li-Yong Wu, Xue-Mei Huang, Yue Wang, Zhao-Bo Yang, Sheng-Hui Su, Chun Wang
OBJECTIVE: To explore the feasibility and clinical effect of posterior spinal canal decompression with pedicle screw fixation and reconstruction of anterior and middle vertebral column for thoracolumbar burst fractures complicated with nerve injury. METHODS: A total of 36 patients with thoracolumbar burst fractures treated from March 2011 to April 2016 were enrolled in the retrospective study. There were 20 males and 16 females, aged from 21 to 52 years old with an average of 37...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29770581/effect-of-static-compression-loads-on-intervertebral-disc-an-in-vivo-bent-rat-tail-model
#9
Wei Xia, Lin-Lin Zhang, Jun Mo, Wen Zhang, Hai-Tao Li, Zong-Ping Luo, Hui-Lin Yang
OBJECTIVE: To evaluate how well different magnitudes of compression-induced degenerative changes using a bent rat tail model simulated human lumbar lordosis. It has been shown that compression plays an important role in intervertebral disc degeneration (IDD). METHODS: Sprague-Dawley rats (n = 25) were instrumented with a special compressive apparatus that was used to bend the intervertebral disc between the 8th and the 10th caudal vertebral bodies using two Kirschner wires inserted percutaneously into the middle of two tail vertebrae...
May 16, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29769040/novel-aggrecan-variant-p-gln2364pro-causes-severe-familial-nonsyndromic-adult-short-stature-and-poor-growth-hormone-response-in-chinese-children
#10
Dandan Xu, Chengjun Sun, Zeyi Zhou, Bingbing Wu, Lin Yang, Zhuo Chang, Miaoying Zhang, Li Xi, Ruoqian Cheng, Jinwen Ni, Feihong Luo
BACKGROUND: Mutations in the aggrecan (ACAN) gene can cause short stature (with heterogeneous clinical phenotypes), impaired bone maturation, and large variations in response to growth hormone (GH) treatment. For such cases, long-term longitudinal therapy data from China are still scarce. We report that a previously unknown ACAN gene variant reduces adult height and we analyze the GH response in children from an affected large Chinese family. METHODS: Two children initially diagnosed with idiopathic short stature (ISS) and a third mildly short child from a large Chinese family presented with poor GH response...
May 16, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29766944/craniovertebral-junction-evaluation-by-computed-tomography-in-asymptomatic-individuals-in-the-indian-population
#11
Chinmaya Dash, Raghav Singla, Mohit Agarwal, Ambuj Kumar, Hitesh Kumar, Shashwat Mishra, Bhawani S Sharma
Background: The available literature on the anatomy and imaging of the craniovertebral junction (CVJ) focusses on the osteometric indices described for the detection of abnormal relationships between the components of CVJ. However, a knowledge of the normal osteometry of this region in the Indian population is critically important for the operating surgeon as it may influence the surgical technique as well as the choice, size and configurations of the implants. It is also important to determine whether critical differences exist between the osteometric data of Indians and the rest of the world for this part of the anatomy...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29766508/repair-of-lumbosacral-fracture-luxation-with-bilateral-twisted-string-of-pearls-locking-plates
#12
U Segal, H Bar, J Shani
OBJECTIVES: To describe a surgical technique using bilateral twisted string-of-pearls locking plates for lumbosacral fracture-luxation in dogs and cats. MATERIALS AND METHODS: Twisted string-of-pearls locking plates were used to stabilise lumbosacral fracture-luxation between 2013 and 2017. Decompression of the cauda equina was achieved by dorsal laminectomy through a dorso-medial approach. Stabilisation was achieved using bilateral string-of-pearls plates attached to the lateral aspects of the vertebral body cranial to the fractured vertebra and the iliosacral joints...
May 15, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29764404/advanced-sporadic-renal-epithelioid-angiomyolipoma-case-report-of-an-extraordinary-response-to-sirolimus-linked-to-tsc2-mutation
#13
Marta Espinosa, Juan Maria Roldán-Romero, Ignacio Duran, Enrique de Álava, María Apellaniz-Ruiz, Alberto Cascón, Carmen Garrigos, Mercedes Robledo, Cristina Rodriguez-Antona
BACKGROUND: Renal epithelioid angiomyolipomas (EAML) are rare tumors with aggressive behavior. EAML can be sporadic or develop within the tuberous sclerosis complex syndrome, where mutations of TSC1 or TSC2 genes (critical negative regulators of mTOR Complex 1) result in an increased activation of mTOR pathway. Optimal EAML treatment, including mTOR inhibitors, remains undetermined. CASE PRESENTATION: Here we present the case of a young adult with a renal EAML that after radical nephrectomy developed metastases, first in liver and then in lumbar vertebrae...
May 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29763351/concomitant-temporomandibular-joint-ankylosis-and-maxillomandibular-fusion-in-a-child-with-klippel-feil-syndrome-a-case-report
#14
Deepika Pai, Abhay T Kamath, Pushpa Kini, Manish Bhagania, Saurabh Kumar
Klippel-Feil syndrome (KFS) is classically characterized by fusion of any of the two of seven cervical vertebrae. It is identified by the presence of a triad of clinical signs including short neck, limitation of head and neck movements and low posterior hairline. Unusual bony malformations leading to facial asymmetry is the most common oral manifestation associated with KFS. Such maxillomandibular fusion can also result in restricted mouth opening in children. It's a challenge to provide complete rehabilitation in such children...
May 15, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29762507/m-health-lessons-learned-by-m-experiences
#15
José Bravo, Ramón Hervás, Jesús Fontecha, Iván González
m-Health is an emerging area that is transforming how people take part in the control of their wellness condition. This vision is changing traditional health processes by discharging hospitals from the care of people. Important advantages of continuous monitoring can be reached but, in order to transform this vision into a reality, some factors need to be addressed. m-Health applications should be shared by patients and hospital staff to perform proper supervised health monitoring. Furthermore, the uses of smartphones for health purposes should be transformed to achieve the objectives of this vision...
May 15, 2018: Sensors
https://www.readbyqxmd.com/read/29762183/butterfly-vertebrae
#16
Curtis C Copeland, Bianca M Conti, L Yvette Fouché-Weber, Thomas Grissom
No abstract text is available yet for this article.
May 15, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29761492/c7-vertebra-homeotic-transformation-in-domestic-dogs-are-pug-dogs-breaking-mammalian-evolutionary-constraints
#17
J Brocal, S De Decker, R José-López, E G Manzanilla, J Penderis, C Stalin, S Bertram, J J Schoenebeck, C Rusbridge, N Fitzpatrick, R Gutierrez-Quintana
The number of cervical vertebrae in mammals is almost constant at seven, regardless of their neck length, implying that there is selection against variation in this number. Homebox (Hox) genes are involved in this evolutionary mammalian conservation, and homeotic transformation of cervical into thoracic vertebrae (cervical ribs) is a common phenotypic abnormality when Hox gene expression is altered. This relatively benign phenotypic change can be associated with fatal traits in humans. Mutations in genes upstream of Hox, inbreeding and stressors during organogenesis can also cause cervical ribs...
May 14, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29761038/a-new-large-bodied-thalattosuchian-crocodyliform-from-the-lower-jurassic-toarcian-of-hungary-with-further-evidence-of-the-mosaic-acquisition-of-marine-adaptations-in-metriorhynchoidea
#18
Attila Ősi, Mark T Young, András Galácz, Márton Rabi
Based on associated and three-dimensionally preserved cranial and postcranial remains, a new thalattosuchian crocodyliform, Magyarosuchus fitosi gen. et sp. nov. from the Lower Jurassic (Upper Toarcian) Kisgerecse Marl Formation, Gerecse Mountains, Hungary is described here. Phylogenetic analyses using three different datasets indicate that M. fitosi is the sister taxon of Pelagosaurus typus forming together the basal-most sub-clade of Metriorhynchoidea. With an estimated body length of 4.67-4.83 m M. fitosi is the largest known non-metriorhynchid metriorhynchoid...
2018: PeerJ
https://www.readbyqxmd.com/read/29760322/effect-of-dietary-difructose-anhydride-iii-supplementation-on-bone-mineral-density-and-calcium-metabolism-in-late-lactation-dairy-cows
#19
Ayami Maetani, Masayuki Ohtani, Kaoru Hatate, Kotaro Matsumoto, Norio Yamagishi
The aim of the present study was to examine the effect of 28 days of dietary difructose anhydride (DFA) III supplementation on calcium (Ca) metabolism in late-lactation dairy cows. Twenty-four multiparous pregnant Holstein cows were divided into two groups. The DFA group was fed total mixed ration (TMR) supplemented with 40 g of DFA III, and the control group was fed TMR only. The replenishment of bone Ca reserves was evaluated by measuring bone mineral density (BMD) and blood biochemical bone markers. Serum Ca concentrations, urinary Ca-to-creatinine (Cre) (Ca/Cre) ratios, and milk Ca concentrations were also analyzed...
May 14, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29758362/the-anti-epileptic-drugs-valproate-carbamazepine-and-levetiracetam-cause-bone-loss-and-modulate-wnt-inhibitors-in-normal-and-ovariectomised-rats
#20
Bushra Parveen, Ambrish Kumar Tiwari, Moon Jain, Subhashis Pal, Naibedya Chattopadhyay, Manjari Tripathi, Divya Vohora
Secondary osteoporosis is the major concern associated with long term intake of antiepileptic drugs (AEDs). Women are the vulnerable targets owing to post-menopausal bone loss. In the present work, we evaluated the effect of 10 weeks of treatment with AED therapy (carbamazepine, CBZ, 75 mg/kg; sodium valproate, SVP, 300 mg/kg; levetiracetam, LTM, 150 mg/kg) on bone mineral density and microarchitecture at femoral epiphysis, lumbar vertebrae and proximal tibia of normal and ovariectomised Wistar rats...
May 11, 2018: Bone
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