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https://www.readbyqxmd.com/read/28920797/description-of-gastric-ulcers-and-of-their-suspected-associated-risk-factors-in-deceased-wild-equids-at-the-r%C3%A3-serve-africaine-de-sigean-france-2010-2016
#1
Benjamin Lamglait, Marielle Vandenbunder-Beltrame, Elodie Trunet, Karin Lemberger
Gastric ulcers are common in domestic horses and foals, affecting at least 90% of unmedicated racehorses in active training. Despite these high prevalences in domestic horses, literature about this condition in wild equids is almost nonexistent. The presence of gastric ulcers was evaluated at necropsy in six species of wild equids that died at the Réserve Africane de Sigean, a safari park in the south of France from 2010 to 2016. Among the 55 individuals that died during that period, a description of the gastric mucosa was available in 82% (45/55) of cases...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28917574/-apparent-worsening-of-psoriasis-lesions-revealing-methotrexate-overdosage
#2
R Haber, B Baroudjian, M Battistella, M Bagot, A Petit
BACKGROUND: Methotrexate (MTX) is an antimetabolite drug used in the treatment of cancers and autoimmune diseases and frequently in dermatology for cutaneous and/or arthritic psoriasis. Toxicities due to MTX overdosage are mainly cutaneous, hepatic and hematologic. Herein, we report a case of MTX overdosage presenting as an erosive and an inflammatory flare of preexisting psoriatic plaques and with new palmar lesions. PATIENTS AND METHODS: A 51-year-old male with a 6-year history of plaque psoriasis resistant to topical corticosteroids was started for the first time on MTX 20mg weekly...
September 13, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28914954/resident-rounds-part-iii-case-report-metastatic-cutaneous-squamous-cell-carcinoma-in-an-african-american-female
#3
Jennifer N Harb, Alexandra L Owens, Kathryn Mooneyham Potter, Michael Montuno, Reordan O De Jesus, Sailesh Konda
Cutaneous squamous cell carcinoma (cSCC) is the most common skin cancer diagnosed in African Americans.<sup>1</sup> Twenty to forty percent of cSCCs reported in African Americans are related to chronic scarring processes or areas of in ammation.<sup>2</sup> Risk factors for developing cSCCs in patients of color include chronic scars resulting from burns, skin ulcers, and radiation sites; and chronic inflammatory diseases such as discoid lupus and hidradenitis suppuritiva.<sup>1</sup> Although skin cancer only accounts for 1% to 2% of cancers diagnosed within African Americans, it is associated with increased morbidity and mortality in this population...
January 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28913339/ulcerative-gastritis-and-esophagitis-in-two-children-with-sarcina-ventriculi-infection
#4
Tim G J de Meij, Michiel P van Wijk, Aart Mookhoek, Andries E Budding
Sarcina ventriculi is a Gram-positive, obligate anaerobic coccus, with a characteristic morphology. Only 22 cases of human infections by this microorganism, including 7 in children, have been reported in literature so far. Affected subjects usually present with abdominal pain, nausea, vomiting, and delayed gastric emptying. However, life-threatening complications, like emphysematous gastritis and gastric perforation have also been described. Gastroparesis and gastric outlet obstruction have been considered as a potential etiologic factor...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28911962/development-and-psychometric-validation-of-a-questionnaire-to-evaluate-nurses-adherence-to-recommendations-for-preventing-pressure-ulcers-qarppu
#5
Ana Belén Moya-Suárez, José Miguel Morales-Asencio, Marta Aranda-Gallardo, Margarita Enríquez de Luna-Rodríguez, José Carlos Canca-Sánchez
AIM OF THE STUDY: The main objective of this work is the development and psychometric validation of an instrument to evaluate nurses' adherence to the main recommendations issued for preventing pressure ulcers. MATERIAL AND METHODS: An instrument was designed based on the main recommendations for the prevention of pressure ulcers published in various clinical practice guides. Subsequently, it was proceeded to evaluate the face and content validity of the instrument by an expert group...
September 5, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28902290/effect-of-secondary-infection-on-epithelialisation-and-total-healing-of-cutaneous-leishmaniasis-lesions
#6
Liliane de Fátima Antonio, Marcelo Rosandiski Lyra, Maurício Naoto Saheki, Armando de Oliveira Schubach, Luciana de Freitas Campos Miranda, Maria de Fátima Madeira, Maria Cristina da Silva Lourenço, Aline Fagundes, Érica Aparecida Dos Santos Ribeiro, Leonardo Barreto, Maria Inês Fernandes Pimentel
BACKGROUND: Cutaneous leishmaniasis (CL) generally presents with a single or several localised cutaneous ulcers without involvement of mucous membranes. Ulcerated lesions are susceptible to secondary contamination that may slow the healing process. OBJECTIVE: This study verified the influence of non-parasitic wound infection on wound closure (epithelialisation) and total healing. METHODS: Twenty-five patients with a confirmed diagnosis of CL and ulcerated lesions underwent biopsy of ulcer borders...
September 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28898558/combination-of-capillaroscopic-and-ultrasonographic-evaluations-in-systemic-sclerosis-results-of-a-cross-sectional-study
#7
Alain Lescoat, Guillaume Coiffier, Marine de Carlan, Catherine Droitcourt, Alice Ballerie, Cazalets Claire, Aleth Perdriger, Jégo Patrick
OBJECTIVES: To compare microvascular damages on nailfold capillaroscopy (NC) with macrovascular manifestations evaluated by hand power doppler ultrasonography (PDUS) in Systemic Sclerosis (SSc) patients, and to assess the associations of these damages with the main digital manifestations of the disease: digital ulcers (DU), acro-osteolysis and Calcinosis. METHODS: NC, hand X-Rays and PDUS were systematically performed in 64 unselected SSc patients. PDUS evaluation with assessment of ulnar artery occlusion (UAO) and finger pulp blood flow (FPBF) was performed blinded for the results of X-Rays and NC...
September 12, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28885076/late-mucosal-ulcers-in-dose-escalated-adaptive-dose-painting-treatments-for-head-and-neck-cancer
#8
Luiza Ana Maria Olteanu, Fréderic Duprez, Wilfried De Neve, Dieter Berwouts, Tom Vercauteren, Wouter Bauters, Philippe Deron, Wouter Huvenne, Katrien Bonte, Ingeborg Goethals, Julie Schatteman, Werner De Gersem
BACKGROUND: To identify predictive factors for the development of late grade 4 mucosal ulcers in adaptive dose-escalated treatments for head-and-neck cancer. MATERIAL AND METHODS: Patient data of four dose-escalated three-phase adaptive dose-painting by numbers (DPBN) clinical trials were analyzed in this study. Correlations between the development of late grade 4 ulcers and factors related with the treatment, disease characteristics and the patient were investigated...
September 8, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28880761/predictive-validity-of-the-braden-scale-for-assessing-risk-of-developing-pressure-ulcers-and-dependence-related-lesions
#9
A Roca-Biosca, L Rubio-Rico, M I de Molina Fernández, N García Grau, G Tuset Garijo, F P García Fernández
OBJECTIVE: In 2014, a new theoretical model explained the mechanism of the development of pressure ulcers (PUs) and that of seven types of lesions known as dependence-related lesions (DRL). The aim of this study was to calculate the incidence of DRL that have been classified as PUs and to check the predictive validity of the Braden scale for assessing DRL in accordance with the new theoretical model in an intensive care unit (ICU). Method This longitudinal, prospective study was conducted in a Spanish ICU...
September 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28878904/a-case-of-choledochoduodenal-fistula-an-unusual-case-report
#10
Bhaviya B S, Abhimanyu Kar, Monalisa Dutta, Ajay Mandal, Sanjay De Bakshi
Choledochoduodenal fistula (CDF) is an abnormal communication between the choledochus and the duodenum, accounts for 5-25% of all internal biliary fistulas. Here, we report a case of CDF secondary to chronic duodenal ulcer who presented with cholangitis. CDF is suspected in case of pneumobilia, and surgery is recommended for refractory cases.
September 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28877863/the-paget-trial-a-multicenter-observational-cohort-intervention-study-for-the-clinical-efficacy-safety-and-immunological-response-of-topical-5-imiquimod-cream-for-vulvar-paget-disease
#11
Michelle van der Linden, Kim Meeuwis, Colette van Hees, Eleonora van Dorst, Johan Bulten, Tjalling Bosse, Joanna IntHout, Dorry Boll, Brigitte Slangen, Manon van Seters, Marc van Beurden, Mariëtte van Poelgeest, Joanne de Hullu
BACKGROUND: Vulvar Paget disease is a rare skin disorder, which is most common in postmenopausal Caucasian women. They usually present with an erythematous plaque that may show fine or typical "cake icing" scaling or ulceration that may cause itching, pain, irritation, or a burning sensation. Although most cases are noninvasive, vulvar Paget disease may be invasive or associated with an underlying vulvar or distant adenocarcinoma. The histological evidence of so-called "Paget cells" with abundant pale cytoplasm in the epithelium confirms the diagnosis...
September 6, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28874779/relation-between-characteristics-of-carotid-atherosclerotic-plaques-and-brain-white-matter-hyperintensities-in-asymptomatic-patients
#12
Enrico Ammirati, Francesco Moroni, Marco Magnoni, Maria A Rocca, Roberta Messina, Nicoletta Anzalone, Costantino De Filippis, Isabella Scotti, Francesca Besana, Pietro Spagnolo, Ornella E Rimoldi, Roberto Chiesa, Andrea Falini, Massimo Filippi, Paolo G Camici
White matter hyperintensities (WMH) can be incidentally found in patients with carotid atherosclerosis on brain magnetic resonance imaging (MRI). We investigated the relationship between WMH and characteristics of carotid plaques in asymptomatic patients without indication for carotid revascularization. We prospectively screened 235 consecutive patients with carotid stenosis <70%. After excluding patients with confounding causes of cerebral damage, 67 asymptomatic patients underwent carotid computed tomography angiography (CTA), contrast-enhanced ultrasound and brain MRI...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870469/first-demonstration-of-equid-gammaherpesviruses-within-the-gastric-mucosal-epithelium-of-horses
#13
Matthew R Pennington, Brieuc G A Cossic, Gillian A Perkins, Carol Duffy, Gerald E Duhamel, Gerlinde R Van de Walle
Horses commonly develop gastric mucosal ulcers, similar to humans, a condition known as equine gastric ulcer syndrome (EGUS) that can lead to poor performance and lost training time and care expenses. Unlike humans, however, an infectious bacterial cause of ulcers has not been conclusively identified. Herpesviruses, while well-established causative agents of diseases such as cold sores, genital lesions, and certain types of cancer, have also been implicated in the development of a subset of gastric ulcers in humans...
September 1, 2017: Virus Research
https://www.readbyqxmd.com/read/28868094/pressure-ulcer-risk-evaluation-in-critical-patients-clinical-and-social-characteristics
#14
Mônica Suêla de Azevedo Macena, Rayanne Suely da Costa Silva, Maria Isabel Da Conceição Dias Fernandes, Ana Beatriz de Almeida Medeiros, Kadyjina Daiane Batista Lúcio, Ana Luisa Brandão de Carvalho Lira
BACKGROUND: Pressure ulcers increase hospital stays and treatment costs due to their complications. Therefore, recognizing factors that contribute to pressure ulcer risk are important to patient safety. OBJECTIVE: To evaluate the association between the scores of the Waterlow, Braden, and Norton scales and clinical and social characteristics in critically ill patients. METHOD: A cross-sectional study of 78 patients in an adult intensive care unit of a university hospital in Northeastern Brazil was conducted from July to December 2015...
2017: Open Nursing Journal
https://www.readbyqxmd.com/read/28866982/protein-profile-of-leprosy-patients-with-plantar-ulcers-from-the-eastern-amazon-region
#15
Marineia Porto de Oliveira, Jorge Rodrigues de Sousa, Rafael Silva de Araujo, Tinara Leila de Sousa Aarão, Juarez Antonio Simões Quaresma
BACKGROUND: Studies investigating the nutritional status of patients with leprosy and plantar ulcers are sparse. Therefore, the objective of this study was to describe the protein profile of leprosy patients with plantar ulcers from the Eastern Amazon region. METHODS: A case record form was created for 75 patients with leprosy (31 with plantar ulcers and 44 without plantar ulcers) with the following data: sociodemographic characteristics, clinical form of leprosy, presence or absence of plantar ulcers, and nutritional assessment using anthropometry consisting of the measurement of body mass index, arm circumference, arm muscle circumference, and triceps skinfold...
September 4, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28862980/management-of-chronic-wounds-diagnosis-preparation-treatment-and-follow-up
#16
Subhas Gupta, Charles Andersen, Joyce Black, Jean de Leon, Caroline Fife, John C Lantis Ii, Jeffrey Niezgoda, Robert Snyder, Bauer Sumpio, William Tettelbach, Terry Treadwell, Dot Weir, Ronald P Silverman
Management of chronic wounds remains challenging in terms of prevalence and complexity. Considerable progress has been made in understanding the science of wound healing during the past decade, sparking volumes of publications and the development of hundreds of dressing and therapy options. There is a need for a simpli ed overview of evidence-based criteria to assist in the accurate diagnosis and appropriate management of chronic wounds in all care settings. An expert panel of 11 wound healing specialists experienced in various care settings convened to discuss best practices and recommended guidelines for managing major chronic wound types...
September 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28860510/a-functional-il1rl1-variant-regulates-corticosteroid-induced-sst2-expression-in-ulcerative-colitis
#17
David Díaz-Jiménez, Lucía Núñez, Marjorie De la Fuente, Karen Dubois-Camacho, Hugo Sepúlveda, Martín Montecino, Alejandro Torres-Riquelme, Paulina García-González, Jonás Chnaiderman, Anna Vossenkamper, Thomas T MacDonald, Daniela Simian, María-Julieta González, John A Cidlowski, Rodrigo Quera, Marcela A Hermoso
The ST2/IL33 signalling pathway has been associated with ulcerative colitis (UC). ST2, encoded by the IL1RL1 gene, is expressed as both a membrane-anchored receptor (ST2L) activated by IL33 and as a soluble receptor (sST2) with anti-inflammatory properties. In UC patients, sST2 is further increased by corticosteroid treatment; however, the glucocorticoid-mediated molecular regulation remains unknown. We therefore tested whether genetic variants in the IL1RL1 distal promoter are involved in UC and affect glucocorticoid-mediated ST2 expression...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28839437/elaboration-and-validation-of-crohn-s-disease-anoperineal-lesions-consensual-definitions
#18
Clémence Horaist, Vincent de Parades, Laurent Abramowitz, Paul Benfredj, Guillaume Bonnaud, Dominique Bouchard, Nadia Fathallah, Agnès Sénéjoux, Laurent Siproudhis, Ghislain Staumont, Manuelle Viguier, Philippe Marteau
AIM: To establish consensual definitions of anoperineal lesions of Crohn's (APLOC) disease and assess interobserver agreement on their diagnosis between experts. METHODS: A database of digitally recorded pictures of APLOC was examined by a coordinating group who selected two series of 20 pictures illustrating the various aspects of APLOC. A reading group comprised: eight experts from the Société Nationale Française de Colo Proctologie group of study and research in proctology and one academic dermatologist...
August 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28837522/risk-factors-and-clinical-outcomes-in-patients-with-ibd-with-melanoma
#19
Loes H C Nissen, Marieke Pierik, Lauranne A A P Derikx, Elke de Jong, Wietske Kievit, Tim R A van den Heuvel, Alexander R van Rosendael, Elsemieke I Plasmeijer, Pieter Dewint, Rob H A Verhoeven, Lucy I H Overbeek, Iris D Nagtegaal, Frank Hoentjen, Andrea E van der Meulen-de Jong
BACKGROUND: Patients with inflammatory bowel disease (IBD) are at increased risk to develop malignant melanoma and this risk may increase with use of anti-tumor necrosis factor (TNF) therapy. Impaired survival of immunosuppressed melanoma patients is reported in transplant and rheumatology patients. This study aims to (1) identify risk factors for melanoma development in patients with IBD, (2) compare clinical characteristics of melanoma in patients with IBD to the general population, and (3) assess the influence of immunosuppressive medication on survival...
August 22, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28835826/an-atypical-case-of-trigeminal-trophic-syndrome-a-legal-medicine-perspective-in-medical-responsibility
#20
Alessandro di Luca, Massimo Ralli, Sara Hemied, Marco de Vincentiis, Natale Mario di Luca
BACKGROUND: Trigeminal trophic syndrome is a rare complication of peripheral or central damage to the trigeminal nerve characterized by anesthesia, paresthesia and a secondary persistent facial ulceration. METHODS: We describe the case of a 40-year-old woman with previous history of Le Fort I osteotomy for a class III malocclusion who developed trigeminal trophic syndrome. Atypically, the cutaneous symptoms appeared bilaterally and 8 years after surgery. RESULTS: Differential diagnosis was based on clinical history, tissue biopsy and serologic evaluation...
2017: SAGE open medical case reports
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