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https://www.readbyqxmd.com/read/29346146/use-of-oxidized-regenerated-cellulose-collagen-matrix-in-chronic-diabetic-foot-ulcers-a-systematic-review
#1
Gisele Chicone, Viviane Fernandes de Carvalho, André Oliveira Paggiaro
OBJECTIVE: Diabetic wounds that do not heal completely usually exhibit inflammatory markers, increased protease activity, and reduced levels of growth factors and cell count. A systematic review was performed to determine whether there is enough evidence to support the use of an oxidized regenerated cellulose/collagen matrix (ORC+C) to treat diabetic foot ulcers (DFUs). METHODS: Study authors analyzed randomized controlled trials (RCTs) on ORC+C dressings for the treatment of DFUs...
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29345298/leishmania-amazonensis-isolated-from-human-visceral-leishmaniasis-histopathological-analysis-and-parasitological-burden-in-different-inbred-mice
#2
Celeste da Silva Freitas de Souza, Kátia da Silva Calabrese, Ana Lúcia Abreu-Silva, Luiz Otávio Pereira Carvalho, Flávia de Oliveira Cardoso, Maria Elizabeth Moraes Cavalheiros Dorval, Elisa Teruya Oshiro, Patrícia Flávia Quaresma, Célia Maria Ferreira Gontijo, Raquel da Silva Pacheco, Maria Isabel Doria Rossi, Sylvio Celso Gonçalves da Costa, Tânia Zaverucha do Valle
Leishmania amazonensis is a major etiological agent of human cutaneous leishmaniasis in the Americas; nevertheless there are some reports of this species causing visceral disease in dogs and men. In the present work we have studied a Leishmania strain isolated from a human case of visceral leishmaniasis. We have infected different mouse strains and analyzed the development of the disease, studying the parasite's ability to visceralize and whether this ability is influenced by host genetics. Female BALB/c, C57BL/6, C57BL/10, CBA, DBA/2, and C3H/He mice were subcutaneously infected with 104 L...
January 18, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29342089/chitosan-gel-to-treat-pressure-ulcers-a-clinical-pilot-study
#3
Virginia Campani, Eliana Pagnozzi, Ilaria Mataro, Laura Mayol, Alessandra Perna, Floriana D'Urso, Antonietta Carillo, Maria Cammarota, Maria Chiara Maiuri, Giuseppe De Rosa
Chitosan is biopolymer with promising properties in wound healing. Chronic wounds represent a significant burden to both the patient and the medical system. Among chronic wounds, pressure ulcers are one of the most common types of complex wound. The efficacy and the tolerability of chitosan gel formulation, prepared into the hospital pharmacy, in the treatment of pressure ulcers of moderate severity were evaluated. The endpoint of this phase II study was the reduction of the area of the lesion by at least 20% after four weeks of treatment...
January 17, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29341035/when-an-unexpected-diagnosis-occurs-a-vaginal-premenopausal-sarcoma
#4
Pedro Marcos-Figueiredo, Diana de Sousa da Costa Moreira, Manuel Gonçalves Morim, Júlia Leite Pereira, Lurdes Silva Salgado
Vaginal cancer is a rare entity. The evidence on its management resides mostly in clinical cases or small case series. Of the histological types, the most frequent is the squamous cell carcinoma, followed by adenocarcinoma. But what to do when identifying an even more infrequent sarcoma in a premenopausal woman? In this study, we describe the case of a 53-year-old woman presenting with metrorrhagia for two months, who was evaluated after an intense episode. A necrotic and ulcerative vaginal swelling was documented and then submitted to biopsy, which revealed a vaginal sarcoma...
January 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29328869/inflammatory-bowel-diseases-and-fermentable-oligosaccharides-disaccharides-monosaccharides-and-polyols-an-overview
#5
Sandra Maria Barbalho, Ricardo de Alvares Goulart, Ana Luíza de Carvalho Aranão, Pamela Grazielle Correa de Oliveira
Inflammatory bowel diseases (IBDs) are mainly represented by ulcerative colitis and Crohn's disease, and the increase in the incidence tends to follow the rapid industrialization and lifestyle of modern societies. FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) consist of molecules that are poorly absorbed in the small intestine and are fermented by bacteria in the colon leading to symptoms such as bloating, flatulence, diarrhea, and abdominal pain. Reduction of the ingestion of FODMAP could reduce the symptoms and improve the quality of life...
January 12, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29319738/the-use-of-nanoparticles-in-wound-treatment-a-systematic-review
#6
Maria Michelle Pereira Silva, Maria Isis Freire de Aguiar, Andrea Bezerra Rodrigues, Maira Di Ciero Miranda, Michell Ângelo Marques Araújo, Isaura Letícia Tavares Palmeira Rolim, Angela Maria Alves E Souza
OBJECTIVE: To analyze the effects of nanoparticle-based dressings on the wound healing process in in vitro animals and human cells based on scientific evidence. METHOD: A systematic review of the literature in LILACS, PubMed and Science Direct databases. The articles were selected and evaluated for the level of evidence by the application of STROBE. RESULTS: The sample consisted of 12 articles. The application of the products occurred in surgical wounds, burns, infected wounds and gingival ulcers in laboratory animals, as well as in vitro tests, demonstrating that among other advantages, the nanoparticle-based dressings increased the healing speed, had good antibacterial capacity and were non cytotoxic agents...
January 8, 2018: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/29317275/increasing-infliximab-dose-based-on-symptoms-biomarkers-and-serum-drug-concentrations-does-not-increase-clinical-endoscopic-or-corticosteroid-free-remission-in-patients-with-active-luminal-crohn-s-disease
#7
Geert D'Haens, Severine Vermeire, Guy Lambrecht, Filip Baert, Peter Bossuyt, Benjamin Pariente, Anthony Buisson, Yoram Bouhnik, Jérôme Filippi, Janneke Vander Woude, Philippe Van Hootegem, Jacques Moreau, Edouard Louis, Denis Franchimont, Martine De Vos, Fazia Mana, Laurent Peyrin-Biroulet, Hedia Brixi, Matthieu Allez, Philip Caenepeel, Alexandre Aubourg, Bas Oldenburg, Marieke Pierik, Ann Gils, Sylvie Chevret, David Laharie
BACKGROUND & AIMS: A combination of infliximab and immunomodulators is the most efficacious treatment for Crohn's disease (CD). Patients have the best outcomes when their serum concentrations of these drugs are above a determined therapeutic threshold. We performed a prospective, randomized trial to determine whether therapeutic drug monitoring (TDM) to maintain serum levels of infliximab above 3 μg/mL produced higher rates of clinical and endoscopic remission than adapting dose based only on symptoms...
January 6, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29316457/topical-chlorhexidine-povidone-iodine-and-erythromycin-in-the-repair-of-traumatic-ulcers-on-the-rat-tongue-clinical-histological-and-microbiological-evaluation
#8
Dieni da Silveira Teixeira, Maria Antonia Zancanaro de Figueiredo, Karen Cherubini, Maria Claudia Rosa Garcia, Sílvia Dias de Oliveira, Fernanda Gonçalves Salum
OBJECTIVE: This study investigated the effect of topical application of 0.12% chlorhexidine, 10% povidone-iodine and 50% erythromycin on the optimization of healing process of traumatic ulcers made on ventral tongue of rats. DESIGN: Forty-Eight Wistar rats were randomly divided into four groups: control, chlorhexidine (Chx), povidone-iodine (PvI) and erythromycin (Er). An ulcer of 5 mm in diameter was made on the ventral tongue of the animals. After 24 h, a microbiological sample was taken and daily application of the substances started...
January 4, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29309774/glycosylation-of-immunoglobulin-g-associates-with-clinical-features-of-inflammatory-bowel-diseases
#9
Mirna Šimurina, Noortje de Haan, Frano Vučković, Nicholas A Kennedy, Jerko Štambuk, David Falck, Irena Trbojević-Akmačić, Florent Clerc, Genadij Razdorov, Anna Khon, Anna Latiano, Renata D'Incà, Silvio Danese, Stephan Targan, Carol Landers, Marla Dubinsky, Dermot P B McGovern, Vito Annese, Manfred Wuhrer, Gordan Lauc
BACKGROUND AND AIMS: Causes of inflammatory bowel diseases are not well understood and the most prominent forms Crohn's disease (CD) and ulcerative colitis (UC) are sometimes hard to distinguish. Glycosylation of immunoglobulin G (IgG) has been associated with CD and UC. IgG Fc-glycosylation affects IgG effector functions. We evaluated changes in IgG Fc-glycosylation associated with UC and CD, as well as with disease characteristics in different patient groups. METHODS: We analyzed 3441 plasma samples, obtained from 2 independent cohorts of patients with CD (874 patients in Italy and 391 in the United States [US]) or UC (1056 in Italy and 253 in the US and healthy individuals (controls) (427 in Italy and 440 in the US)...
January 5, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29295637/clostridial-collagenase-ointment-and-medicinal-honey-utilization-for-pressure-ulcers-in-u-s-hospitals
#10
Jill Dreyfus, Gary Delhougne, Bobbie James, Julie Gayle, Curtis Waycaster
AIMS: Describe the utilization of clostridial collagenase ointment (CCO) and medicinal honey debridement methods in real-world inpatient and outpatient hospital settings among pressure ulcer (PU) patients and compare the frequency of healthcare re-encounters between CCO- and medicinal honey-treated patients. MATERIALS AND METHODS: De-identified hospital discharge records for patients receiving CCO or medicinal honey methods of debridement and having an ICD-9 code for PU were extracted from the U...
January 3, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29290657/diagnostic-classification-of-endosonography-for-differentiating-colorectal-ulcerative-diseases-a-new-statistical-method
#11
En-Qi Qiu, Wen Guo, Tian-Ming Cheng, Yong-Li Yao, Wei Zhu, Si-De Liu, Fa-Chao Zhi
AIM: To establish a classification method for differential diagnosis of colorectal ulcerative diseases, especially Crohn's disease (CD), primary intestinal lymphoma (PIL) and intestinal tuberculosis (ITB). METHODS: We searched the in-patient medical record database for confirmed cases of CD, PIL and ITB from 2008 to 2015 at our center, collected data on endoscopic ultrasound (EUS) from randomly-chosen patients who formed the training set, conducted univariate logistic regression analysis to summarize EUS features of CD, PIL and ITB, and created a diagnostic classification method...
December 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29290654/prevalence-of-and-risk-factors-for-work-disability-in-dutch-patients-with-inflammatory-bowel-disease
#12
Lieke M Spekhorst, Bas Oldenburg, Ad A van Bodegraven, Dirk J de Jong, Floris Imhann, Andrea E van der Meulen-de Jong, Marieke J Pierik, Janneke C van der Woude, Gerard Dijkstra, Geert D'Haens, Mark Löwenberg, Rinse K Weersma, Eleonora A M Festen
AIM: To determine the prevalence of work disability in inflammatory bowel disease (IBD), and to assess risk factors associated with work disability. METHODS: For this retrospective cohort study, we retrieved clinical data from the Dutch IBD Biobank on July 2014, containing electronic patient records of 3388 IBD patients treated in the eight University Medical Centers in the Netherlands. Prevalence of work disability was assessed in 2794 IBD patients and compared with the general Dutch population...
December 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29290146/multifunctional-role-of-35-kilodalton-hyaluronan-in-promoting-defense-of-the-intestinal-epithelium
#13
Sean P Kessler, Dana R Obery, Kourtney P Nickerson, Aaron C Petrey, Christine McDonald, Carol A de la Motte
Intestinal epithelium plays a critical role in host defense against orally acquired pathogens. Dysregulation of this protective barrier is a primary driver of inflammatory bowel diseases (Crohn's and ulcerative colitis) and also infant gastrointestinal infections. Previously, our lab reported that hyaluronan (HA) isolated from human milk induces the expression of the antimicrobial peptide β-defensin in vivo and protects against Salmonella Typhimurium infection of epithelial cells in vitro. In addition, we demonstrated that commercially available 35 kDa size HA induces the expression of β-defensin, upregulates the expression of tight junction protein zonula occludens-1 (ZO-1), and attenuates murine Citrobacter rodentium infection in vivo...
December 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29286175/hyperbaric-oxygen-therapy-an-alternative-treatment-for-radiation-induced-cutaneous-ulcers
#14
Inés Fernández Canedo, Laura Padilla España, José Francisco Millán Cayetano, Juan Bosco Repiso Jiménez, Manuel Pérez Delgado, Magdalena de Troya Martín
Radiotherapy is a widely recognised treatment for non-melanoma skin cancer. We report three cases of radiation-induced skin ulcers in which hyperbaric oxygen therapy was administered in 90-min sessions, 5 days a week at 2.4 absolute atmospheres in a multiplace hyperbaric chamber. Hyperbaric oxygen therapy is an outpatient treatment that does not displace other classical treatments and may be used as an adjunct therapy.
December 29, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/29279186/digital-dermatitis-in-dairy-cattle-the-contribution-of-different-disease-classes-to-transmission
#15
Floor Biemans, Piter Bijma, Natasja M Boots, Mart C M de Jong
Digital Dermatitis (DD) is a claw disease mainly affecting the hind feet of dairy cattle. Digital Dermatitis is an infectious disease, transmitted via the environment, where the infectious "agent" is a combination of bacteria. The standardized classification for DD lesions developed by Döpfer et al. (1997) and extended by Berry et al. (2012) has six distinct classes: healthy (M0), an active granulomatous area of 0-2 cm (M1), an ulcerative lesion of >2 cm (M2), an ulcerative lesion covered by a scab (M3), alteration of the skin (M4), and a combination of M4 and M1 (M4...
December 22, 2017: Epidemics
https://www.readbyqxmd.com/read/29278418/aberrant-dna-methylation-is-associated-with-aggressive-clinicopathological-features-and-poor-survival-in-cutaneous-melanoma
#16
B de Unamuno Bustos, R Murria Estal, G Pérez Simó, J Simarro Farinos, C Pujol Marco, M Navarro Mira, V Alegre de Miquel, R Ballester Sánchez, V Sabater Marco, M Llavador Ros, S Palanca Suela, R Botella Estrada
BACKGROUND: Promoter methylation of tumor suppressor genes (TSGs) has recently been implicated in the pathogenesis of several types of cancer. Regarding melanoma, over a hundred genes that contribute to its pathogenesis have been identified to be aberrantly hypermethylated. This is a retrospective observational study that aims to analyze the prevalence of CpG island methylation in a series of primary melanoma, to identify the associations with the main clinicopathological features, and to explore the prognostic significance of methylation in melanoma survival...
December 26, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29277718/effect-of-allantoin-on-experimentally-induced-gastric-ulcers-pathways-of-gastroprotection
#17
Dayane Moreira da Silva, José Luís Rodrigues Martins, Danillo Ramos de Oliveira, Iziara Ferreira Florentino, Daiany Priscilla Bueno da Silva, Fernanda Cristina Alcântara Dos Santos, Elson Alves Costa
Gastric ulcer affects people worldwide, and its inefficacy and recurrence have fueled the search for new therapeutic strategies. Despite the well-known use of allantoin in medicines and cosmetic products, its effect has not yet been studied with regard to gastric ulcer. Hence, the aim of the present study was to explore the pharmaco-mechanistic efficacy of allantoin against commonly harmful agents that cause injuries to the stomach. Ethanol, indomethacin, and stress-induced gastric ulcer models were adopted, in addition to pylorus ligature, a quantification of vascular permeability, glutathione (GSH), gastric adhered mucus, prostaglandin (PGE2), pro-inflammatory cytokines levels, myeloperoxidase (MPO), and catalase (CAT) activities...
December 22, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29275001/recommendations-of-the-spanish-working-group-on-crohn-s-disease-and-ulcerative-colitis-geteccu-and-the-association-of-crohn-s-disease-and-ulcerative-colitis-patients-accu-in-the-management-of-psychological-problems-in-inflammatory-bowel-disease-patients
#18
Manuel Barreiro-de Acosta, Ignacio Marín-Jiménez, Abel Panadero, Jordi Guardiola, Mercedes Cañas, Milena Gobbo Montoya, Yolanda Modino, Guillermo Alcaín, Marta Maia Bosca-Watts, Xavier Calvet, Francesc Casellas, María Chaparro, Luis Fernández Salazar, Rocío Ferreiro-Iglesias, Daniel Ginard, Marisa Iborra, Noemí Manceñido, Miriam Mañosa, Olga Merino, Montserrat Rivero, Oscar Roncero, Laura Sempere, Pablo Vega, Yamile Zabana, Miguel Mínguez, Pilar Nos, Javier P Gisbert
AIMS: To establish recommendations for the management of psychological problems affecting patients with inflammatory bowel disease (IBD). METHODS: A meeting of a group of IBD experts made up of doctors, psychologists, nurses and patient representatives was held. The following were presented: 1) Results of a previous focal group, 2) Results of doctor and patient surveys, 3) Results of a systematic review of tools for detecting anxiety and depression. A guided discussion was then held about the most important psychological and emotional problems associated with IBD, appropriate referral criteria and situations to be avoided...
December 20, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29273315/staphylococcus-aureus-triggers-induction-of-mir-15b-5p-to-diminish-dna-repair-and-de-regulate-inflammatory-response-in-diabetic-foot-ulcers
#19
Horacio A Ramirez, Irena Pastar, Ivan Jozic, Olivera Stojadinovic, Rivka C Stone, Nkemcho Ojeh, Joel Gil, Stephen C Davis, Robert S Kirsner, Marjana Tomic-Canic
Diabetic foot ulcers (DFUs) are a debilitating complication of diabetes in which bacterial presence, including its frequent colonizer Staphylococcus aureus, contribute to inhibition of healing. MicroRNAs (miRs) play a role in healing and host response to bacterial pathogens. However, the mechanisms by which miR response to cutaneous S. aureus contributes to DFU pathophysiology are unknown. Herein we show S. aureus inhibits wound closure and induces miR-15b-5p in acute human and porcine wound models, and in chronic DFUs...
December 19, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29258704/acute-infection-due-to-mycobacterium-marinum-in-a-patient-with-ulcerative-colitis-and-metabolic-syndrome-on-infliximab-therapy
#20
Patricia Ramírez de la Piscina, Elvira Delgado, Ileana Duca, Silvia Estrada, Rosario Calderón, Marta Salvador, Francisco García Campos
No abstract text is available yet for this article.
December 16, 2017: Gastroenterología y Hepatología
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