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https://www.readbyqxmd.com/read/27920769/transcriptional-profiling-of-type-ii-toxin-antitoxin-genes-of-helicobacter-pylori-under-different-environmental-conditions-identification-of-hp0967-hp0968-system
#1
María G Cárdenas-Mondragón, Miguel A Ares, Leonardo G Panunzi, Sabino Pacheco, Margarita Camorlinga-Ponce, Jorge A Girón, Javier Torres, Miguel A De la Cruz
Helicobacter pylori is a Gram-negative bacterium that colonizes the human gastric mucosa and is responsible for causing peptic ulcers and gastric carcinoma. The expression of virulence factors allows the persistence of H. pylori in the stomach, which results in a chronic, sometimes uncontrolled inflammatory response. Type II toxin-antitoxin (TA) systems have emerged as important virulence factors in many pathogenic bacteria. Three type II TA systems have previously been identified in the genome of H. pylori 26695: HP0315-HP0316, HP0892-HP0893, and HP0894-HP0895...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27902515/comparison-of-health-related-quality-of-life-and-disability-in-ulcerative-colitis-patients-following-restorative-proctocolectomy-with-ileal-pouch-anal-anastomosis-versus-anti-tumor-necrosis-factor-therapy
#2
Sara van Gennep, Saloomeh Sahami, Christianne J Buskens, Gijs R van den Brink, Cyriel Y Ponsioen, André D'Hoore, Anthony de Buck van Overstraeten, Gert van Assche, Marc Ferrante, Séverine Vermeire, Willem A Bemelman, Geert R A M D'Haens, Mark Löwenberg
BACKGROUND AND AIMS: Health-related quality of life (HRQL) and disability were compared in ulcerative colitis (UC) patients who underwent restorative proctocolectomy versus patients who received treatment with anti-tumor necrosis factor (anti-TNF) agents. PATIENTS AND METHODS: UC patients who underwent restorative proctocolectomy or started anti-TNF treatment between January 2010 and January 2015 were included at two tertiary referral centers. A matched cohort was created using propensity score matching for the covariates disease duration, Montreal classification, age, and sex...
November 29, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27902390/virulence-determinants-in-clinical-staphylococcus-aureus-from-monomicrobial-and-polymicrobial-infections-of-diabetic-foot-ulcers
#3
Kavitha Shettigar, Spoorthi Jain, Deepika V Bhat, Raviraj Acharya, Lingadakai Ramachandra, Kapaettu Satyamoorthy, T S Murali
Antibiotic resistance in Staphylococcus aureus is a major public health concern and Methicillin Resistant S. aureus has emerged as an important pathogen. We characterized S. aureus isolates from monomicrobial and polymicrobial wound infections from 200 diabetic individuals with foot ulcers to understand their underlying diversity and pathogenicity. Staphylococcal Cassette Chromosome mec typing was performed and genes coding for production of biofilm, Panton-Valentine Leukocidin, Toxic Shock Syndrome Toxin, Leukotoxins DE and M were screened...
October 19, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27898939/evaluating-pellet-and-meal-feeding-regimens-on-finishing-pig-performance-stomach-morphology-and-carcass-characteristics
#4
J A De Jong, J M DeRouchey, M D Tokach, S S Dritz, R D Goodband, J C Woodworth, M W Allerson
A total of 2,100 pigs (PIC 327 × 1050; initially 31.2 kg BW) were used in a 118-d trial to determine the effects of pellet or meal feeding regimens on finishing pig growth performance, stomach morphology, and carcass characteristics. Pens of pigs were balanced by initial BW and randomly allotted to 1 of 6 dietary treatments (14 pens/treatment with 25 pigs/pen). Pens were sorted by gender allowing for 7 barrow pens and 7 gilt pens per treatment. The same corn-soybean meal-based diets containing 15% dried distillers' grains with solubles were used for all treatments and fed in 5 phases...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27889483/classification-surgical-management-and-outcomes-of-patients-with-gastrogastric-fistula-after-roux-en-y-gastric-bypass
#5
Lara Ribeiro-Parenti, Gregoire De Courville, Abdenasser Daikha, Konstantinos Arapis, Denis Chosidow, Jean-Pierre Marmuse
BACKGROUND: Gastrogastric fistula (GGF) is a known complication after Roux-en-Y gastric bypass that can lead to marginal ulceration (MU) and failure of weight loss. OBJECTIVES: To describe our experience with GGF management and propose a classification of GGF based on its anatomic location. SETTING: University hospital, France. METHODS: After internal review board approval, data from all patients with a GGF were reviewed...
September 28, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27878223/experimental-study-with-nursing-staff-related-to-the-knowledge-about-pressure-ulcers
#6
Miriam Viviane Baron, Cézane Priscila Reuter, Miria Suzana Burgos, Veniria Cavalli, Cristine Brandenburg, Suzane Beatriz Frantz Krug
Objective: to compare the scores of knowledge in teams participating or not participating in educational interventions about pressure ulcers. Method: a quantitative study with experimental design. Data were collected through a validated questionnaire. The study included 71 individuals, including nurses and nursing technicians from three intensive care units, divided into intervention group and control group. Data analysis considered the scores of the groups in the moment before and after intervention...
November 21, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27878218/nursing-care-missed-in-patients-at-risk-of-or-having-pressure-ulcers
#7
Jonathan Hermayn Hernández Valles, María Guadalupe Moreno Monsiváis, Ma Guadalupe Interial Guzmán, Leticia Vázquez Arreola
Objective: to determine the nursing care missed as perceived by the nursing staff and its relation with the nursing care missed identified in the assessment of patients at risk of or having pressur ulcers. Method: descriptive correlation study. The participants were 161 nurses and 483 patients from a public hospital. The MISSCARE survey was used in combination with a Nursing Care Assessment Form for Patients at Risk of or having pressure ulcers. For the analysis, descriptive and inferential statistics were used...
November 21, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27877040/intestinal-anti-inflammatory-effects-of-rgd-functionalized-silk-fibroin-nanoparticles-in-trinitrobenzenesulfonic-acid-induced-experimental-colitis-in-rats
#8
Alba Rodriguez-Nogales, Francesca Algieri, Laura De Matteis, A Abel Lozano-Perez, Jose Garrido-Mesa, Teresa Vezza, J M de la Fuente, Jose Luis Cenis, Julio Gálvez, Maria Elena Rodriguez-Cabezas
BACKGROUND: Current treatment of inflammatory bowel disease is based on the use of immunosuppressants or anti-inflammatory drugs, which are characterized by important side effects that can limit their use. Previous research has been performed by administering these drugs as nanoparticles that target the ulcerated intestinal regions and increase their bioavailability. It has been reported that silk fibroin can act as a drug carrier and shows anti-inflammatory properties. PURPOSE: This study was designed to enhance the interaction of the silk fibroin nanoparticles (SFNs) with the injured intestinal tissue by functionalizing them with the peptide motif RGD (arginine-glycine-aspartic acid) and to evaluate the intestinal anti-inflammatory properties of these RGD-functionalized silk fibroin nanoparticles (RGD-SFNs) in the trinitrobenzenesulfonic acid (TNBS) model of rat colitis...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27871896/gastroprotective-and-ulcer-healing-effects-of-hydroethanolic-extract-of-leaves-of-caryocar-coriaceum-mechanisms-involved-in-the-gastroprotective-activity
#9
Luis Jardelino de Lacerda Neto, Andreza Guedes Barbosa Ramos, Valterlucio Santos Sales, Severino Denicio Gonçalves de Souza, Antonia Thassya Lucas Dos Santos, Larissa Rolim de Oliveira, Marta Regina Kerntopf, Thais Rodrigues de Albuquerque, Henrique Douglas Melo Coutinho, Lucindo Jose Quintans-Júnior, Almir Gonçalves Wanderley, Irwin Rose Alencar de Menezes
This work aimed to determine the chemical fingerprint of hydroethanolic extract of leaves of Caryocar coriaceum (HELCC) and the gastroprotective activity. The chemical fingerprint of HELCC was analyzed by HPLC-DAD, to quantify total phenols and flavonoids were carried out by Folin-Ciocalteu reagent and aluminum chloride assay, while in vitro antioxidant activity was evaluated by the DPPH method. The methods used to determine pharmacological activity were: gastroprotective screening test in classical models of induced acute and chronic gastric lesions and physical barrier test...
November 18, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27869384/-atypical-mucocutaneous-manifestations-in-neonates-and-infants-with-chikungunya-fever-in-the-municipalities-of-c%C3%A3%C2%BAcuta-los-patios-and-villa-del-rosario-norte-de-santander-colombia-2014
#10
Claudia Marcela Muñoz, José Orlando Castillo, Daniela Salas, Milena Alexandra Valderrama, Claudia Teresa Rangel, Heiddy Patricia Vargas, Diana Carolina Silva
INTRODUCTION: Atypical clinical manifestations have been observed in newborns and infants suffering from fever caused by the chikungunya virus. Objective: To describe the cases of fever caused by the chikungunya virus in newborns and infants with atypical mucocutaneous lesions. Materials and methods: We reviewed the clinical records, as well as lab tests and histopathological results, of newborns and infants diagnosed with Chikungunya virus and atypical mucocutaneous lesions in three regional hospitals...
September 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27865503/effect-of-claw-disorders-on-milk-production-fertility-and-longevity-and-their-economic-impact-in-spanish-holstein-cows
#11
N Charfeddine, M A Pérez-Cabal
The aims of this study were (1) to estimate the phenotypic association between different degrees of severity of claw disorders and production, fertility performance, and longevity in Spanish dairy cattle, and (2) to quantify its economic impact at the animal and herd level. In this study, claw data comprised 108,468 trimmings collected between 2012 and 2014 by 25 trimmers from 804 Holstein dairy herds. The claw disorders considered were the 3 most frequent disorders in Spanish dairy herds: dermatitis (DE), sole ulcer (SU), and white line disease (WL)...
November 16, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27864055/gastroprotective-effect-and-chemical-characterization-of-a-polysaccharide-fraction-from-leaves-of-croton-cajucara
#12
Adamara M Nascimento, Daniele Maria-Ferreira, Evana Figueiredo J de Souza, Lauro M de Souza, Guilherme L Sassaki, Marcello Iacomini, Maria Fernanda de P Werner, Thales R Cipriani
Croton cajucara Benth. is a tree from the Amazon Forest, where it is known as sacaca. Its leaves and barks are used in medicinal preparations to treat different diseases, including gastric ulcers. The crude polysaccharide fraction (CCP), obtained from the hot aqueous extract of C. cajucara leaves, was able to promote gastroprotection on an ethanol induced gastric ulcer model. Therefore, a bioguided fractionation was performed to isolate the active polysaccharide fraction. After freezing-thawing, ultrafiltration and dialyses at 100, 50, and 25kDa cut-off membranes, fraction 25R was obtained...
November 15, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27863590/quality-of-life-of-people-with-chronic-ulcers
#13
Karina de Fátima Rodrigues Dos Santos, Paula Rogéria da Silva, Valéria Tristão Ferreira, Elaine Aparecida Rocha Domingues, Ivandira Ribeiro Anselmo Simões, Rogério Silva Lima, Neusa Maria Costa Alexandre
INTRODUCTION: Patients with chronic ulcers have physical, social, and psychological changes that directly affect their quality of life. OBJECTIVES: To evaluate the quality of life and analyze the association between personal and health characteristics in patient quality of life for those with chronic ulcers. METHOD: A cross-sectional study, nonprobabilistic. The questionnaire to evaluate personal and health characteristics and the Ferrans and Power Quality of Life Index-Wound Version were used for the data collection...
December 2016: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/27862714/de-novo-inflammatory-bowel-disease-after-pediatric-kidney-or-liver-transplant
#14
Melissa A Fernandes, Hillary J Braun, Kim Evason, Sue Rhee, Emily R Perito
A subset of children who receive a liver and/or kidney transplant develop de novo inflammatory bowel disease-like chronic intestinal inflammation, not explained by infection or medications, following transplant. We have conducted a single-center, retrospective case series describing the unique clinical and histologic features of this IBD-like chronic intestinal inflammation following solid organ transplant. At our center, nine of 327 kidney or liver recipients developed de novo IBD following transplant (six liver, two kidney, one liver-kidney)...
November 11, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27851860/dermatopulmonary-syndrome-associated-with-anti-mda5-antibodies-after-allogeneic-hematopoietic-stem-cell-transplantation
#15
Clémence Lepelletier, Djaouida Bengoufa, Zeltni Lyes, Adèle de Masson, François Chasset, Marie Jachiet, David Michonneau, Marie Robin, Régis Peffault de Latour, Flore Sicre de Fontbrune, Yacine Tandjaoui-Lambiotte, Armand Bensussan, Michel Rybojad, Abdellatif Tazi, Martine Bagot, Gérard Socié, Anne Bergeron, Jean-David Bouaziz
Importance: Chronic graft-vs-host-disease (cGVHD) after allogeneic stem cell transplantation (AHSCT) may resemble autoimmune diseases. Anti-MDA5 (melanoma differentiation-associated gene 5) dermatopulmonary syndrome is a subset of dermatomyositis defined by specific clinical features and detection of anti-MDA5-antibodies in the serum. Objective: To characterize the clinical features of patients who underwent AHSCT and screened positively for anti-MDA5 antibodies...
November 16, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27849283/social-repercussions-experienced-by-elderly-with-venous-ulcer
#16
Aline Cristiane de Sousa Azevedo Aguiar, Dora Sadigursky, Lucas Amaral Martins, Tânia Maria de Oliva Menezes, Alana Libânia de Souza Santos, Luana Araújo Dos Reis
Objective: Understand the social consequences experienced by elderly affected by venous ulcers. Methodology: descriptive and exploratory study with a qualitative approach carried out in 2012 with eight participants at a physiotherapy clinic in the state of Bahia. Data was collected through semi-structured interviews and analyzed through Bardin's thematic content analysis. Results: They showed that elderly patients with venous leg ulcers have become victims of prejudice, discrimination and have experienced embarrassment and shame in their daily routines because of the chronic wounds in their bodies, which makes than different from other people...
October 31, 2016: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/27847125/mitotic-rate-correlates-with-sentinel-lymph-node-status-and-outcome-in-cutaneous-melanoma-greater-than-1%C3%A2-millimeter-in-thickness-a-multi-institutional-study-of-1524-cases
#17
Mario Mandalà, Francesca Galli, Laura Cattaneo, Barbara Merelli, Eliana Rulli, Simone Ribero, Pietro Quaglino, Vincenzo De Giorgi, Jacopo Pigozzo, Vanna Chiarion Sileni, Alessandra Chirco, Pier Francesco Ferrucci, Marcella Occelli, Gianlorenzo Imberti, Dario Piazzalunga, Daniela Massi, Carlo Tondini, Paola Queirolo
BACKGROUND: The 7th edition of the TNM American Joint Committee on Cancer classification incorporates mitotic rate (MR) only for primary cutaneous melanoma (PCM) with Breslow thickness (BT) ≤1 mm. OBJECTIVE: To investigate whether and to what extent MR is able to predict sentinel lymph node (SLN) status and clinical outcome of PCM patients with BT >1 mm. METHODS: The study included consecutive patients with PCM. Logistic regression and Cox regression model were used to analyze the impact of MR on SLN status, disease-free survival (DFS), and overall survival...
November 12, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27833392/efficacy-of-thioguanine-treatment-in-inflammatory-bowel-disease-a-systematic-review
#18
Berrie Meijer, Chris Jj Mulder, Godefridus J Peters, Adriaan A van Bodegraven, Nanne Kh de Boer
AIM: To critically assess the available literature regarding the efficacy of thioguanine treatment in inflammatory bowel disease (IBD) patients, irrespective of the (hepato-) toxicity profile. METHODS: A systematic literature search of the MEDLINE database using PubMed was performed using the keywords "thioguanine", "6-TG", "thioguanine", "inflammatory bowel disease", "IBD", "Crohn's disease", "Ulcerative colitis" and "effectiveness" in order to identify relevant articles published in English starting from 2000...
October 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27828650/leg-ulcer-in-lepromatous-leprosy-case-report
#19
Tania Rita Moreno de Oliveira Fernandes, Talita Suzany Siqueira Dos Santos, Ramon Rodrigues de Macedo Lopes
In Brazil, leprosy is a widespread infectious and contagious disease. Clinicians and specialists view leprosy broadly as a systemic infection, since, in its manifestations, it mimics many conditions, such as rheumatic, vascular, ENT, neurological and dermatological diseases. There are few studies that characterize the factors associated with ulcers in leprosy. These injuries should be prevented and treated promptly to avoid serious problems like secondary infections, sepsis, carcinomatous degeneration and amputations...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27828625/clinical-management-of-localized-bcg-adverse-events-in-children
#20
Thais das Neves Fraga Moreira, Maria Isabel de Moraes-Pinto, Beatriz Tavares Costa-Carvalho, Anete Sevciovic Grumach, Lily Yin Weckx
BCG adverse events (BCG-AE) are rare conditions with no well-established treatment. This study aims to describe clinical characteristics and outcome of localized BCG-AE. Children with BCG-AEs who were treated at the Reference Center for Special Immunobiologicals of the Federal University of São Paulo from 2009 to 2011 were included. Patients were followed monthly until 3 months after healing. One hundred and twenty-seven patients with localized BCG-AE were followed: 67 (52.7%) had suppurative lymphadenitis; 30 (23...
November 3, 2016: Revista do Instituto de Medicina Tropical de São Paulo
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