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https://www.readbyqxmd.com/read/28428053/discrimination-between-ulcerative-colitis-and-crohn-s-disease-using-phage-display-identified-peptides-and-virus-mimicking-synthetic-nanoparticles
#1
Sonia Facchin, Liboria Digiglio, Renata D'Incà, Elisabetta Casarin, Elisa Dassie, Monica Dettin, Annj Zamuner, Andrea Buda, Michele De Boni, Duilio Della Libera, Alessandra D'Urso, Giacomo Carlo Sturniolo, Margherita Morpurgo
Discrimination between Crohn Disease (CD) and Ulcerative Colitis (UC) is an unsolved clinical issue in up to 10-15% of inflammatory bowel disease (IBD) patients. We developed a method capable to discriminate between the two clinical conditions by combining random peptide phage display screenings and nanoparticle (NP) based assays. We identified two peptides able to recognize selectively biopsies of inflamed mucosa of either CD or UC patients. The peptides were integrated into synthetic virus-mimicking nanoassemblies using a poly-avidin NP platform...
April 17, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28422869/effects-of-jianpi-qingchang-decoction-on-the-quality-of-life-of-patients-with-ulcerative-colitis-a-randomized-controlled-trial
#2
Yan-Cheng Dai, Lie Zheng, Ya-Li Zhang, Xuan Chen, De-Liang Chen, Zhi-Peng Tang
This study aims to determine the effects of the Jianpi Qingchang decoction (JQD) on the quality of life (QOL) of patients with spleen deficiency and dampness-heat syndrome ulcerative colitis (UC).A total of 120 active UC patients with spleen deficiency and dampness-heat syndrome were enrolled into this study. These patients were randomly divided into 2 groups: test group and control group (n = 60, each group). Patients in the test group were treated with JQD, while patients in control group were treated with 5-amino salicylic acid...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28410605/frosted-branch-angiitis-and-cerebral-venous-sinus-thrombosis-as-an-initial-onset-of-neuro-beh%C3%A3-et-s-disease-a-case-report-and-review-of-the-literature
#3
Bruno Fortaleza de Aquino Ferreira, Ever Ernesto Caso Rodriguez, Leandro Lara do Prado, Celio Roberto Gonçalves, Carlos Eduardo Hirata, Joyce Hisae Yamamoto
BACKGROUND: Frosted branch angiitis is a rare, severe condition. It can be either a primary or a secondary condition and is characterized by rapid deterioration of vision and fulminant retinal vasculitis that manifests as diffuse sheathing of retinal vessels, macular edema, papillitis, vitritis and anterior uveitis. We aimed to describe a case of frosted branch angiitis and cerebral venous sinus thrombosis as an initial neuro-Behçet's disease onset. Diagnosis of Behçet's disease was based on the current 2014 International Criteria for Behçet's Disease and the International consensus recommendation criteria for neuro-Behçet's disease...
April 15, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28408791/all-trans-retinoic-acid-modulates-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway-targeting-tnf-%C3%AE-and-nitric-oxide-synthase-2-expression-in-colonic-mucosa-during-ulcerative-colitis-and-colitis-associated-cancer
#4
Hayet Rafa, Sarra Benkhelifa, Sonia AitYounes, Houria Saoula, Said Belhadef, Mourad Belkhelfa, Aziza Boukercha, Ryma Toumi, Imene Soufli, Olivier Moralès, Yvan de Launoit, Hassen Mahfouf, M'hamed Nakmouche, Nadira Delhem, Chafia Touil-Boukoffa
Colitis associated cancer (CAC) is the colorectal cancer (CRC) subtype that is associated with bowel disease such as ulcerative colitis (UC). The data on role of NF-κB signaling in development and progression of CAC were derived from preclinical studies, whereas data from human are rare. The aim of this work was to study the contribution of NF-κB pathway during UC and CAC, as well as the immunomodulatory effect of all-trans retinoic acid (AtRA). We analyzed the expression of NOS2, TNF-α, TLR4, and NF-κB, in colonic mucosa...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28407649/lymphogranuloma-venereum-serovar-l2b-presenting-with-painful-genital-ulceration-an-emerging-clinical-presentation
#5
Roger Haber, Ismaël Maatouk, Bertille de Barbeyrac, Martine Bagot, Michel Janier, Sébastien Fouéré
These 5 cases of atypical inflammatory lymphogranula venereum (LGV) serovar L2b presenting initially with edema and persistent painful ulceration illustrate that clinical manifestations of LGV in the current outbreak in men who have sex with men reflect the influence of both the serovars virulence and the host immune system and are not confined to proctitis. L2b serovar could have a particular high virulence profile, and the need for awareness of LGV as a cause of genital ulceration is crucial.
May 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28405731/reduced-bone-mass-and-preserved-marrow-adipose-tissue-in-patients-with-inflammatory-bowel-diseases-in-long-term-remission
#6
C M Bastos, I M Araújo, M H Nogueira-Barbosa, C E G Salmon, F J A de Paula, L E A Troncon
Bone marrow adipose tissue has not been studied in patients with inactive inflammatory bowel disease. We found that these patients have preserved marrow adiposity even with low bone mass. Factors involved in bone loss in active disease may have long-lasting effects but do not seem to affect bone marrow adiposity. INTRODUCTION: Reduced bone mass is known to occur at varying prevalence in patients with inflammatory bowel diseases (IBD) because of inflammation, malnutrition, and steroid therapy...
April 12, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28405140/diet-and-microbiota-in-inflammatory-bowel-disease-the-gut-in-disharmony
#7
REVIEW
Davy C M Rapozo, Claudio Bernardazzi, Heitor Siffert Pereira de Souza
Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and disease states. Recently, quantitative and qualitative changes in the composition of the gut microbiota have been detected in Crohn's disease and ulcerative colitis, reinforcing the hypothesis of dysbiosis as a relevant mechanism underlying inflammatory bowel disease (IBD) pathogenesis. Humans and microbes have co-existed and co-evolved for a long time in a mutually beneficial symbiotic association essential for maintaining homeostasis...
March 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28403297/knowledge-of-the-nursing-team-on-pressure-ulcer-prevention
#8
Nariani Souza Galvão, Maria Alice Barbosa Serique, Vera Lúcia Conceição de Gouveia Santos, Paula Cristina Nogueira
OBJECTIVE: describe and analyze the nursing team's knowledge about classification, evaluation and measures to prevent pressure ulcers (PU) in patients hospitalized in the ICU of a teaching hospital in the city of Manaus. METHOD: a descriptive and exploratory study was conducted after approval by a research ethics committee. Data were collected using a validated instrument. The study sample was made up of 40 nursing staff members, of whom 14 were nurses and 26 were nursing technicians/aides...
April 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28403291/impact-of-home-visits-on-the-functional-capacity-of-patients-with-venous-ulcers
#9
Fabiana Lopes Joaquim, Alessandra Conceição Leite Funchal Camacho, Rose Mary Costa Rosa Andrade Silva, Bruna Silva Leite, Raquel Santos de Queiroz, Cíntia Raquel da Costa de Assis
OBJECTIVE: to compare the impact of home visits, before and after instructions, on the functional capacity of adult and elderly patients with venous ulcers, by means of the KATZ-EIAVD Scale. METHOD: experimental, clinical, randomized, non-blind and controlled study, developed with 32 patients (case and control groups). The research settings were the Wound Care Clinic of the University Hospital Antonio Pedro, and the homes of patients assisted in this clinic. Data collection took place from February to June 2014, by means of a health unit evaluation tool, the KATZ-EIAVD Scale, and a script of instructions to be given to the research subjects that had received a home visit...
April 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28403284/unna-s-boot-experience-of-care-of-people-with-venous-ulcers
#10
Marcelo Henrique da Silva, Maria Cristina Pinto de Jesus, Deíse Moura de Oliveira, Miriam Aparecida Barbosa Merighi
OBJECTIVE: to understand the experience of care of people with venous ulcers using an Unna's boot. METHOD: a qualitative study, based on the social phenomenology by Alfred Schütz, was carried out with 12 adults interviewed in 2015. The statements were analyzed and organized in thematic categories. RESULTS: the following categories emerged: "Unna's boot annoyance versus wound improvement", "Difficulties for accessing care with the Unna's boot", "Care for healing and preventing recurrence", and "Receiving more attention from the healthcare professional"...
April 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28402995/etiopathogenesis-of-inflammatory-bowel-disease-today-and-tomorrow
#11
Heitor S P de Souza
PURPOSE OF REVIEW: Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD), represent chronic diseases of unknown cause, and they are regarded as prototypical complex diseases. Despite all the recent advances, a complete appreciation of the pathogenesis of IBD is still limited. In this review, we present recent information contributing to a better understanding of mechanisms underlying IBD. RECENT FINDINGS: Here, we attempt to highlight novel environmental triggers, data on the gut microbiota, its interaction with the host, and the potential influence of diet and food components...
April 11, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28399595/can-the-pessary-use-modify-the-vaginal-microbiological-flora-a-cross-sectional-study
#12
Suelene Costa de Albuquerque Coelho, Paulo César Giraldo, Juliana Oquendo Florentino, Edilson Benedito de Castro, Luiz Gustavo Oliveira Brito, Cássia Raquel Teatin Juliato
Introduction Vaginal pessary is used as a conservative treatment for pelvic organ prolapse (POP). Some studies have shown that common complaints of its use may include vaginal discomfort and increased vaginal discharge. Scant information is available about the microflora status after using this device. Objective To determine if the usage of vaginal pessary can interfere with the vaginal environment. Methods A cross-sectional study was performed from March of 2014 to July of 2015 including 90 women with POP...
April 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28398347/microbial-shifts-and-signatures-of-long-term-remission-in-ulcerative-colitis-after-faecal-microbiota-transplantation
#13
Susana Fuentes, Noortje G Rossen, Mirjam J van der Spek, Jorn Ha Hartman, Laura Huuskonen, Katri Korpela, Jarkko Salojärvi, Steven Aalvink, Willem M de Vos, Geert R D'Haens, Erwin G Zoetendal, Cyriel Y Ponsioen
Faecal microbiota transplantation (FMT) may contribute towards disease remission in ulcerative colitis (UC), but it is unknown which factors determine long-term effect of treatment. Here, we aimed to identify bacterial signatures associated with sustained remission. To this end, samples from healthy donors and UC patients-grouped into responders and non-responders at a primary end point (week 12) and further stratified by sustained clinical remission and relapse assessed at ⩾1-year follow-up were analysed, comparing the efficacy of FMT from either a healthy donor or autologous faeces...
April 11, 2017: ISME Journal
https://www.readbyqxmd.com/read/28397443/an-evaluation-of-dual-source-computed-tomography-used-with-the-de-weert-classification-to-detect-vulnerable-plaque-using-ivus-virtual-histology-as-a-standard-of-reference
#14
Bartosz Dołęga-Kozierowski, Piotr Klimeczek, Michał Lis, Róża Krycińska, Anna Chrapusta, Urszula Zaleska-Dorobisz, Jerzy Garcarek, Wojciech Witkiewicz
BACKGROUND: One of the main risk factors for cerebral ischemic events is atherosclerotic disease of the internal carotid artery (ICA). Nowadays, increasing attention is being paid to the relationship between the morphological features of atherosclerotic plaque and the occurrence of stroke. Several studies have demonstrated that the presence of specific vulnerable plaque types, with a large lipid core and thin fibrous cap, can be used as an independent risk predictor of cerebral ischemic events...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28396682/heterologous-fibrin-sealant-derived-from-snake-venom-from-bench-to-bedside-an-overview
#15
REVIEW
Rui Seabra Ferreira, Luciana Curtolo de Barros, Luciana Patrícia Fernandes Abbade, Silvia Regina Catharino Sartori Barraviera, Maria Regina Cavariani Silvares, Leticia Gomes de Pontes, Lucilene Delazari Dos Santos, Benedito Barraviera
Hemostatic and adhesive agents date back to World War II, when homologous fibrin sealant came onto scene. Considering that infectious diseases can be transmitted via human blood, a new heterologous fibrin sealant was standardized in the 1990s. Its components were a serine protease (a thrombin-like enzyme) extracted from the venom of Crotalus durissus terrificus snakes and a fibrinogen-rich cryoprecipitate extracted from the blood of Bubalus bubalis buffaloes. This new bioproduct has been used as a coagulant, sealant, adhesive and recently as a candidate scaffold for mesenchymal stem cells and bone and cartilage repair...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28395107/ebv-positive-b-cell-proliferations-of-varied-malignant-potential-2015-sh-eahp-workshop-report-part-1
#16
Yasodha Natkunam, John R Goodlad, Amy Chadburn, Daphne de Jong, Dita Gratzinger, John K C Chan, Jonathan Said, Elaine S Jaffe
Objectives: The 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology aimed to review B-cell proliferations of varied malignant potential associated with immunodeficiency. Methods: The Workshop Panel reviewed all cases of B-cell hyperplasias, polymorphic B-lymphoproliferative disorders, Epstein-Barr virus (EBV)-positive mucocutaneous ulcer, and large B-cell proliferations associated with chronic inflammation and rendered consensus diagnoses...
February 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28388655/functional-toll-like-receptor-tlr-2-polymorphisms-in-the-susceptibility-to-inflammatory-bowel-disease
#17
Helga Paula Török, Victor Bellon, Astrid Konrad, Martin Lacher, Laurian Tonenchi, Matthias Siebeck, Stephan Brand, Enrico Narciso De Toni
BACKGROUND: The recent genome-wide association studies (GWAS) in inflammatory bowel disease (IBD) suggest significant genetic overlap with complex mycobacterial diseases like tuberculosis or leprosy. TLR variants have previously been linked to susceptibility for mycobacterial diseases. Here we investigated the contribution to IBD risk of two TLR2 polymorphisms, the low-prevalence variant Arg753Gln and the GTn microsatellite repeat polymorphism in intron 2. We studied association with disease, possible correlations with phenotype and gene-gene interactions...
2017: PloS One
https://www.readbyqxmd.com/read/28386282/ulcerated-lesion-of-the-tongue-as-manifestation-of-systemic-coccidioidomycosis
#18
Luis A Mendez, Sergio A Flores, Ricardo Martinez, Oslei Paes de Almeida
Systemic mycoses and their oral manifestations are very rare. We present a case of a 60-year-old man with an ulcerated lesion on the lateral border of the tongue. Histologic studies revealed a granulomatous fungal infection by Coccidioides immitis. After pharmacological treatment, the lesion resolved. Recently, northern Mexico has been reported to be an endemic zone of C. immitis infections; therefore it should be considered in the differential diagnosis of mouth lesions. A comprehensive clinical history, physical exploration, and complementary studies are essential for an accurate diagnosis...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28380117/reactivation-of-cutaneous-and-mucocutaneous-tegumentary-leishmaniasis-in-rheumatoid-arthritis-patients-an-emerging-problem
#19
Regina Maia de Souza, Heitor Franco de Andrade, Maria Irma Seixas Duarte, Lucia Maria Almeida Braz, Armando de Oliveira Schubach, Fátima Conceição Silva, Valdir Sabbaga Amato
Rheumatoid arthritis (RA) is a chronic condition that is frequent in patients living in tropical areas exposed to leishmaniasis. RA therapy involves immunosuppressant drugs such as methotrexate (MTX), monoclonal antibodies (mAbs) and prednisone. We report an unusual presentation of cutaneous (CL) or mucocutaneous leishmaniasis (ML) in RA patients from an endemic area of leishmaniasis. A 51-year-old woman noted a cutaneous ulcer on her left ankle during MTX and prednisone RA therapy. Initially diagnosed as a venous stasis ulcer, the aspirate of the injury revealed the presence of Leishmania DNA...
April 3, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28377581/no-association-of-alcohol-use-and-the-risk-of-ulcerative-colitis-or-crohn-s-disease-data-from-a-european-prospective-cohort-study-epic
#20
M M Bergmann, V Hernandez, W Bernigau, H Boeing, S S M Chan, R Luben, K-T Khaw, F van Schaik, B Oldenburg, B Bueno-de-Mesquita, K Overvad, D Palli, G Masala, F Carbonnel, M-C Boutron-Ruault, A Olsen, A Tjonneland, R Kaaks, V Katzke, E Riboli, A R Hart
No abstract text is available yet for this article.
April 2017: European Journal of Clinical Nutrition
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