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https://www.readbyqxmd.com/read/28526612/histomorphological-observation-of-surgical-debridement-combined-with-negative-pressure-therapy-in-treatment-of-diabetic-foot
#1
Jiao-Yun Dong, Fei Song, Chun Qing, Shu-Liang Lu
PURPOSE: To further study the mechanism of epithelization on the fascia side of the flap after surgical incision and the treatment of the negative pressure therapy. METHODS: With the patients' informed consent, parts of tissue samples were obtained from a 51-year-old diabetic patient who was suffering lower extremity ulcers. The samples were processed with hematoxylin and eosin (HE) staining and Masson trichrome staining. The keratin 19, keratin 15 and carcino-embryonic antigen (CEA) were immunohistochemically detected...
April 20, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28526427/atypical-presentations-of-cutaneous-leishmaniasis-a-systematic-review
#2
REVIEW
Camilla Barros Meireles, Laís Chaves Maia, Gustavo Coelho Soares, Ilara Parente Pinheiro Teodoro, Maria do Socorro Vieira Gadelha, Cláudio Gleidiston Lima da Silva, Marcos Antonio Pereira de Lima
Cutaneous Leishmaniasis (CL) is endemic in 88 countries, showing relevant prevalences. The aim of this study was to perform a systematic review on atypical lesions of CL around the world, addressing clinico-epidemiological, immunological and therapeutic aspects. A search of the literature was conducted via electronic databases Scopus and PubMed for articles published between 2010 and 2015. The search terms browsed were "cutaneous leishmaniasis", "atypical" and "unusual". Based on the eligibility criteria, 34 out of 122 articles were included in the final sample...
May 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28524250/one-plant-many-uses-a-review-of-the-pharmacological-applications-of-morinda-citrifolia
#3
REVIEW
Mylena Andréa Oliveira Torres, Isadora de Fátima Braga Magalhães, Renata Mondêgo-Oliveira, Joicy Cortez de Sá, Alessandra Lima Rocha, Ana Lucia Abreu-Silva
Morinda citrifolia, also known as noni, is commonly used in popular medicine in Brazil. Many parts of the noni tree are utilized in such practices, including the roots, leaves and seeds. Through a search of online databases, the present article reviews 92 research studies on the biological actions of M. citrifolia. The paper will discuss the therapeutic effects of noni and its compounds in a variety of forms of presentation, focusing on studies that support its traditional use. A large and diverse number of properties were identified, which were divided into immunostimulatory, antitumor, antidiabetic, anti-obesity, antibacterial and anti-septic, antifungal, antiviral, leishmanicidal, antiinflammatory, antinociceptive and analgesic, antioxidant, neuroprotective, wound healing, antiallergic, antiangiogenic, antiemetic and anti-nausea, anti-gastric ulcer and oesophagitis, anthelmintic, antimutagenic, antipsychotic, anxiolytic, photoprotective, anti-wrinkle and periodontal tissue regeneration activities...
May 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28523493/the-socio-economic-impact-of-work-disability-due-to-inflammatory-bowel-disease-in-brazil
#4
Renata de S B Fróes, Ana Teresa Pugas Carvalho, Antonio Jose de V Carneiro, Adriana Maria Hilu de Barros Moreira, Jessica P L Moreira, Ronir R Luiz, Heitor S de Souza
BACKGROUND: Inflammatory bowel disease (IBD) might have economic and social impacts in Brazil, where its prevalence has increased recently. This study aimed to assess disability due to IBD in the Brazilian population and demographic factors potentially associated with absence from work. METHODS: Analysis was performed using the computerized Single System of Social Security Benefits Information, with a cross-check for aid pension and disability retirement, for Crohn's disease (CD) and ulcerative colitis (UC)...
May 18, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28513805/third-european-evidence-based-consensus-on-diagnosis-and-management-of-ulcerative-colitis-part-2-current-management
#5
Marcus Harbord, Rami Eliakim, Dominik Bettenworth, Konstantinos Karmiris, Konstantinos Katsanos, Uri Kopylov, Torsten Kucharzik, Tamás Molnár, Tim Raine, Shaji Sebastian, Helena Tavares de Sousa, Axel Dignass, Franck Carbonnel
No abstract text is available yet for this article.
January 28, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28513576/biofilm-is-a-major-virulence-determinant-in-bacterial-colonization-of-chronic-skin-ulcers-independently-from-the-multidrug-resistant-phenotype
#6
Enea Gino Di Domenico, Ilaria Farulla, Grazia Prignano, Maria Teresa Gallo, Matteo Vespaziani, Ilaria Cavallo, Isabella Sperduti, Martina Pontone, Valentina Bordignon, Laura Cilli, Alessandra De Santis, Fabiola Di Salvo, Fulvia Pimpinelli, Ilaria Lesnoni La Parola, Luigi Toma, Fabrizio Ensoli
Bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (MDROs). Nevertheless, a quantitative correlation between biofilm production and the profile of antimicrobial drug resistance in delayed wound healing remains to be determined. Microbial identification, antibiotic susceptibility and biofilm production were assessed in 135 clinical isolates from 87 patients. Gram-negative bacteria were the most represented microorganisms (60...
May 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28512689/long-term-results-of-fibular-achilles-tenodesis-westin-s-tenodesis-for-paralytic-pes-calcaneus-is-hypercorrection-avoidable-a-longitudinal-retrospective-study
#7
Helder Henzo Yamada, Patricia Maria Moraes de Barros Fucs
PURPOSE: The purpose of this study was to review all cases of patients submitted to Westin's tenodesis, who had calcaneus feet secondary to myelomeningocele sequel, in order to evaluate the anatomical change provided by surgery and also to verify, in a long-term follow-up, the inversion of the deformity depending on the patient's age. METHODS: In this longitudinal retrospective study, all medical records of patients with myelomeningocele sequelae submitted to Westin's tenodesis from 1993 to 2013 in a public university hospital were reviewed...
May 16, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28509590/health-care-costs-associated-with-australian-tertiary-inflammatory-bowel-disease-care
#8
Belinda Jackson, Danny Con, Ronald Ma, Alexandra Gorelik, Danny Liew, Peter De Cruz
INTRODUCTION: We aimed to describe the total costs of illness for IBD patients and compare the costs of patients with active disease to those with inactive disease. MATERIALS AND METHODS: Resource use for IBD management was itemized for attributable costs (AUD) among all IBD patients over a 12-month period at an Australian hospital. RESULTS: One hundred and eighty-three patients were included (87 ulcerative colitis (UC); 93 Crohn's disease (CD); three IBD-unclassified)...
May 16, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28501878/-oral-manifestations-of-ulcerative-colitis
#9
C X W Tan, H S Brand, N K H de Boer, T Forouzanfar
Ulcerative colitis is an inflammatory bowel disease occurring relatively frequently in industrialised regions of the world. Pyostomatitis vegetans is the most characteristic pathognomonic oral manifestation but other oral abnormalities like aphthous lesions, caries and periodontitis are more prevalent in patients with ulcerative colitis. Oral care providers must be aware of these problems if they are to provide adequate oral care.
May 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28500815/oral-pentoxifylline-associated-with-pentavalent-antimony-a-randomized-trial-for-cutaneous-leishmaniasis
#10
Graça Brito, Mayra Dourado, Luiz Henrique Guimarães, Everson Meireles, Albert Schriefer, Edgar Marcelino de Carvalho, Paulo Roberto Lima Machado
AbstractCutaneous leishmaniasis (CL) by Leishmania braziliensis is associated with decreasing cure rates in Brazil. Standard treatment with pentavalent antimony (Sb(v)) cures only 50-60% of the cases. The immunopathogenesis of CL ulcer is associated with high interferon-γ and tumor necrosis factor (TNF) production. Pentoxifylline, a TNF inhibitor, has been successfully used in association with Sb(v) in mucosal and cutaneous leishmaniasis. This randomized, double-blind, and placebo-controlled trial aimed to evaluate the efficacy and safety of oral pentoxifylline plus Sb(v) versus placebo plus Sb(v) in patients with CL in Bahia, Brazil...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28499034/functional-disability-and-its-predictors-in-systemic-sclerosis-a-study-from-the-desscipher-project-within-the-eustar-group
#11
Veronika K Jaeger, Oliver Distler, Britta Maurer, Laszlo Czirják, Veronika Lóránd, Gabriele Valentini, Serena Vettori, Francesco Del Galdo, Giuseppina Abignano, Christopher Denton, Svetlana Nihtyanova, Yannick Allanore, Jerome Avouac, Gabriele Riemekasten, Elise Siegert, Dörte Huscher, Marco Matucci-Cerinic, Serena Guiducci, Marc Frerix, Ingo H Tarner, Beata Garay Toth, Beat Fankhauser, Jörg Umbricht, Anastasia Zakharova, Carina Mihai, Franco Cozzi, Sule Yavuz, Nicolas Hunzelmann, Simona Rednic, Alessandra Vacca, Tim Schmeiser, Valeria Riccieri, Paloma García de la Peña Lefebvre, Armando Gabrielli, Brigitte Krummel-Lorenz, Duska Martinovic, Codrina Ancuta, Vanessa Smith, Ulf Müller-Ladner, Ulrich A Walker
Objectives.: The multisystem manifestations of SSc can greatly impact patients' quality of life. The aim of this study was to identify factors associated with disability in SSc. Methods.: SSc patients from the prospective DeSScipher cohort who had completed the scleroderma health assessment questionnaire (SHAQ), a disability score that combines the health assessment questionnaire and five visual analogue scales, were included in this analysis. The effect of factors possibly associated with disability was analysed with multiple linear regressions...
May 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28498563/identification-of-factors-associated-with-treatment-refractoriness-of-oral-lesions-in-pemphigus-vulgaris
#12
S Kumar, D De, S Handa, R K Ratho, S Bhandari, A Pal, P Kamboj, S Sarkar
BACKGROUND: Oral mucosal lesions of pemphigus vulgaris (PV) are known to show more treatment refractoriness than skin lesions. OBJECTIVES: To identify the role of different clinical and laboratory parameters in the treatment refractoriness in the oral lesions of PV. METHODS: This prospective study recruited 50 adult patients of PV having oral lesions. Patients were given treatment appropriate for overall disease severity. Treatment refractoriness was defined arbitrarily as less than 75% reduction in oral objective Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) after treatment for 6 months...
May 12, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28498343/anti-helicobacter-pylori-activity-of-isocoumarin-paepalantine-morphological-and-molecular-docking-analysis
#13
João Paulo L Damasceno, Ricardo P Rodrigues, Rita de Cássia R Gonçalves, Rodrigo R Kitagawa
The Helicobacterpylori bacterium is one of the main causes of chronic gastritis, peptic ulcers, and even gastric cancer. It affects an average of half of the world population. Its difficult eradication depends upon multi-drug therapy. Since its classification as a group 1 carcinogenic by International Agency for Research on Cancer (IARC), the importance of H. pylori eradication has obtained a novel meaning. There is considerable interest in alternative therapies for the eradication of H. pylori using compounds from a wide range of natural products...
May 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28489260/histologic-changes-associated-with-talaporfin-sodium-mediated-photodynamic-therapy-in-rat-skin
#14
Wesley J Moy, Jonathan Yao, Sébastien M de Feraudy, Sean M White, Jocelynda Salvador, Kristen M Kelly, Bernard Choi
BACKGROUND AND OBJECTIVE: Alternative treatments are needed to achieve consistent and more complete port wine stain (PWS) removal, especially in darker skin types; photodynamic therapy (PDT) is a promising alternative treatment. To this end, we previously reported on Talaporfin Sodium (TS)-mediated PDT. It is essential to understand treatment tissue effects to design a protocol that will achieve selective vascular injury without ulceration and scarring. The objective of this work is to assess skin changes associated with TS-mediated PDT with clinically relevant treatment parameters...
May 10, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28489215/negative-pressure-therapy-for-the-treatment-of-complex-wounds
#15
Renan Victor Kümpel Schmidt Lima, Pedro Soler Coltro, Jayme Adriano Farina
The objective of this study is to evaluate the effectiveness of negative pressure therapy (NPT) in the treatment of complex wounds, with emphasis on its mechanisms of action and main therapeutic indications. We searched the Pubmed / Medline database for articles published from 1997 to 2016, and selected the most relevant ones. The mechanisms of action of NPT involveboth physical effects, such as increased perfusion, control of edema and exudate, reduction of wound dimensions and bacterial clearance, and biological ones, such as the stimulation of granulation tissue formation, microdeformations and reduction of Inflammatory response...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28489214/efficacy-of-bacterial-cellulose-membrane-for-the-treatment-of-lower-limbs-chronic-varicose-ulcers-a-randomized-and-controlled-trial
#16
Luciana Marins Cavalcanti, Flávia Cristina Morone Pinto, Glícia Maria DE Oliveira, Salvador Vilar Correia Lima, José Lamartine DE Andrade Aguiar, Esdras Marques Lins
Objective: to evaluate the efficacy of Bacterial Cellulose (BC) membrane dressings in the treatment of lower limb venous ulcers. Methods: we carried out a prospective, randomized, controlled study of 25 patients with chronic venous ulcer disease in the lower limbs from the Angiology and Vascular Surgery Service of the Federal University of Pernambuco Hospital and from the Salgado Polyclinic of the County Health Department, Caruaru, Pernambuco. We randomly assigned patients to two groups: control group, receiving dressings with triglyceride oil (11 patients) and experimental group, treated with BC membrane (14 patients)...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28485309/reticulate-erythema-with-ulceration
#17
Rajsmita Bhattacharjee, Keshavamurthy Vinay, Dipankar De, Anindita Sinha, Uma Nahar Saikia
No abstract text is available yet for this article.
May 8, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28472309/impact-on-experimental-colitis-of-vitamin-d-receptor-deletion-in-intestinal-epithelial-or-myeloid-cells
#18
Carlien Leyssens, Lieve Verlinden, Gert De Hertogh, Shigeaki Kato, Conny Gysemans, Chantal Mathieu, Geert Carmeliet, Annemieke Verstuyf
Inflammatory bowel diseases are gastrointestinal diseases including Crohn's disease and ulcerative colitis. The chronic inflammation is thought to result from an excessive inflammatory response to environmental factors such as luminal bacteria in genetically predisposed individuals. Studies revealed that mice with impaired vitamin D signaling are more susceptible to experimental colitis. To better understand the contribution of vitamin D signaling in different cells of the gut to this disease, we investigated the effects of intestinal-specific or myeloid vitamin D receptor deletion...
May 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28465717/protein-signature-characterizing-helicobacter-pylori-strains-of-patients-with-autoimmune-atrophic-gastritis-duodenal-ulcer-and-gastric-cancer
#19
Valli De Re, Ombretta Repetto, Stefania Zanussi, Mariateresa Casarotto, Laura Caggiari, Vincenzo Canzonieri, Renato Cannizzaro
BACKGROUND: Helicobacter pylori (H. pylori) represents a key factor in the etiology of autoimmune atrophic gastritis (AAG), duodenal ulcer (DU) and gastric cancer (GC). The aim of this study was to characterize the differential protein expression of H. pylori isolated from gastric biopsies of patients affected by either AAG, DU or GC. METHODS: The H. pylori strains were isolated from endoscopic biopsies from the stomach of patients with gastric disease. Protein profiles of H...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28465149/diabetic-foot-ulcer-carries-high-amputation-and-mortality-rates-particularly-in-the-presence-of-advanced-age-peripheral-artery-disease-and-anemia
#20
Rafael Henrique Rodrigues Costa, Natália Anício Cardoso, Ricardo Jayme Procópio, Túlio Pinho Navarro, Alan Dardik, Ligia de Loiola Cisneros
INTRODUCTION: Foot ulcer is also a clinical marker for limb amputation and for death in diabetic patients. The purpose of this study was to determine amputation and mortality rates and its associated factors in patients with diabetic foot ulcerations in a tertiary hospital in Brazil. METHODS: Retrospective medical records from 654 diabetic foot patients were reviewed. The risk factors were determined using the conditional logistic regression model analysis. RESULTS: The mean patient age was 63...
April 12, 2017: Diabetes & Metabolic Syndrome
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