keyword
MENU ▼
Read by QxMD icon Read
search

pharmacology,probiotics

keyword
https://www.readbyqxmd.com/read/28736228/dbz-is-a-putative-ppar%C3%AE-agonist-that-prevents-high-fat-diet-induced-obesity-insulin-resistance-and-gut-dysbiosis
#1
Pengfei Xu, Fan Hong, Jialin Wang, Jing Wang, Xia Zhao, Sheng Wang, Tingting Xue, Jingwei Xu, Xiaohui Zheng, Yonggong Zhai
BACKGROUND: The nuclear receptor PPARγ is an effective pharmacological target for some types of metabolic syndrome, including obesity, diabetes, nonalcoholic fatty liver disease, and cardiovascular disease. However, the current PPARγ-targeting thiazolidinedione drugs have undesirable side effects. Danshensu Bingpian Zhi (DBZ), also known as tanshinol borneol ester derived from Salvia miltiorrhiza, is a synthetic derivative of natural compounds used in traditional Chinese medicine for its anti-inflammatory activity...
July 20, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28732069/saccharomyces-boulardii-cncm-i-745-supplementation-reduces-gastrointestinal-dysfunction-in-an-animal-model-of-ibs
#2
Paola Brun, Melania Scarpa, Chiara Marchiori, Gloria Sarasin, Valentina Caputi, Andrea Porzionato, Maria Cecilia Giron, Giorgio Palù, Ignazio Castagliuolo
BACKGROUND: We evaluated the effect of Saccharomyces boulardii CNCM I-745 on intestinal neuromuscular anomalies in an IBS-type mouse model of gastrointestinal motor dysfunctions elicited by Herpes Simplex Virus type 1 (HSV-1) exposure. METHODS: Mice were inoculated intranasally with HSV-1 (102 PFU) or vehicle at time 0 and 4 weeks later by the intragastric (IG) route (108 PFU). Six weeks after IG inoculum, mice were randomly allocated to receive oral gavage with either S...
2017: PloS One
https://www.readbyqxmd.com/read/28729815/symposium-report-an-evidence-based-approach-to-ibs-and-cic-applying-new-advances-to-daily-practice-a-review-of-an-adjunct-clinical-symposium-of-the-american-college-of-gastroenterology-meeting-october-16-2016-%C3%A2-las-vegas-nevada
#3
William D Chey
Many nonpharmacologic and pharmacologic therapies are available to manage irritable bowel syndrome (IBS) and chronic idiopathic constipation (CIC). The American College of Gastroenterology (ACG) regularly publishes reviews on IBS and CIC therapies. The most recent of these reviews was published by the ACG Task Force on the Management of Functional Bowel Disorders in 2014. The key objective of this review was to evaluate the efficacy of therapies for IBS or CIC compared with placebo or no treatment in randomized controlled trials...
February 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28686541/the-role-of-probiotics-in-children-with-autism-spectrum-disorder-a-prospective-open-label-study
#4
Sanaa Y Shaaban, Yasmin G El Gendy, Nayra S Mehanna, Waled M El-Senousy, Howaida S A El-Feki, Khaled Saad, Osama M El-Asheer
OBJECTIVE: There are limited data on the efficacy of probiotics in children with ASD, therefore, this study aims to evaluate the efficacy and tolerability of probiotics in an Egyptian cohort of children with ASD. METHODS: Gastrointestinal (GI) flora were assessed by quantitative real-time PCR of stool samples of 30 autistic children from 5 to 9 years old. GI symptoms of autistic children were assessed with a modified six-item Gastrointestinal Severity Index (6-GSI) questionnaire, and autistic symptoms were assessed with Autism Treatment Evaluation Checklist (ATEC) before and after 3 months of supplementation of probiotics nutritional supplement formula (each gram contains 100 × 10(6) colony forming units of three probiotic strains; Lactobacillus acidophilus, Lactobacillus rhamnosus and Bifidobacteria longum)...
July 7, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28679372/fermented-herbal-formula-kiom-ma-128-protects-against-acute-colitis-induced-by-dextran-sodium-sulfate-in-mice
#5
Dong-Gun Kim, Mi-Ra Lee, Jae-Myung Yoo, Kwang-Il Park, Jin-Yeul Ma
BACKGROUND: Colitis is a well-known subtype of inflammatory bowel disease and is caused by diverse factors. Previous research has shown that KIOM-MA elicits anti-inflammatory and anti-allergic effects on various diseases. KIOM-MA-128, our novel herbal formula, was generated from KIOM-MA using probiotics to improve the therapeutic efficacy. We investigated whether KIOM-MA-128 has protective activity in a mouse model of acute colitis induced by dextran sodium sulfate (DSS). METHODS: Colitis was induced by DSS administered to ICR mice in drinking water...
July 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28640632/gut-microbiota-nitric-oxide-and-microglia-as-prerequisites-for-neurodegenerative-disorders
#6
Joyce K Y Tse
Regulating fluctuating endogenous nitric oxide (NO) levels is necessary for proper physiological functions. Aberrant NO pathways are implicated in a number of neurological disorders, including Alzheimer's disease (AD) and Parkinson's disease. The mechanism of NO in oxidative and nitrosative stress with pathological consequences involves reactions with reactive oxygen species (e.g., superoxide) to form the highly reactive peroxynitrite, hydrogen peroxide, hypochloride ions and hydroxyl radical. NO levels are typically regulated by endogenous nitric oxide synthases (NOS), and inflammatory iNOS is implicated in the pathogenesis of neurodegenerative diseases, in which elevated NO mediates axonal degeneration and activates cyclooxygenases to provoke neuroinflammation...
July 7, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28431202/pharmacological-interventions-for-acute-pancreatitis
#7
REVIEW
Elisabetta Moggia, Rahul Koti, Ajay P Belgaumkar, Federico Fazio, Stephen P Pereira, Brian R Davidson, Kurinchi Selvan Gurusamy
BACKGROUND: In people with acute pancreatitis, it is unclear what the role should be for medical treatment as an addition to supportive care such as fluid and electrolyte balance and organ support in people with organ failure. OBJECTIVES: To assess the effects of different pharmacological interventions in people with acute pancreatitis. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL, 2016, Issue 9), MEDLINE, Embase, Science Citation Index Expanded, and trial registers to October 2016 to identify randomised controlled trials (RCTs)...
April 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28413079/mexican-consensus-on-dyspepsia
#8
R Carmona-Sánchez, O Gómez-Escudero, M Zavala-Solares, M V Bielsa-Fernández, E Coss-Adame, A I Hernández-Guerrero, F Huerta-Iga, M E Icaza-Chávez, M A Lira-Pedrín, J A Lizárraga-López, A López-Colombo, A Noble-Lugo, J Pérez-Manauta, R H Raña-Garibay, J M Remes-Troche, J L Tamayo, L F Uscanga, F Zamarripa-Dorsey, M A Valdovinos Díaz, J A Velarde-Ruiz Velasco
Since the publication of the 2007 dyspepsia guidelines of the Asociación Mexicana de Gastroenterología, there have been significant advances in the knowledge of this disease. A systematic search of the literature in PubMed (01/2007 to 06/2016) was carried out to review and update the 2007 guidelines and to provide new evidence-based recommendations. All high-quality articles in Spanish and English were included. Statements were formulated and voted upon using the Delphi method. The level of evidence and strength of recommendation of each statement were established according to the GRADE system...
April 14, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28411687/oral-administration-of-red-ginseng-powder-fermented-with-probiotic-alleviates-the-severity-of-dextran-sulfate-sodium-induced-colitis-in-a-mouse-model
#9
Sun-Hee Jang, Jisang Park, Sae-Hae Kim, Kyung-Min Choi, Eun-Sil Ko, Jeong-Dan Cha, Young-Ran Lee, Hyonseok Jang, Yong-Suk Jang
Red ginseng is a well-known alternative medicine with anti-inflammatory activity. It exerts pharmacological effects through the transformation of saponin into metabolites by intestinal microbiota. Given that intestinal microflora vary among individuals, the pharmacological effects of red ginseng likely vary among individuals. In order to produce homogeneously effective red ginseng, we prepared probiotic-fermented red ginseng and evaluated its activity using a dextran sulfate sodium (DSS)-induced colitis model in mice...
March 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28397382/immunotropic-aspect-of-the-bacillus-coagulans-probiotic-action
#10
Tatiana V Bomko, Tatiana N Nosalskaya, Tatiana V Kabluchko, Yury V Lisnyak, Artur V Martynov
OBJECTIVES: Currently, probiotics are increasingly used as the alternative to antibiotics as well as the preventive measures in humans. In particular, probiotics occupy a key position in the treatment of antibiotics-associated intestinal dysbiosis. A spore-forming microorganism lactobacillus Bacillus coagulans is one of the most promising probiotics. However, some of its pharmacological effects remain poorly understood. This study was aimed at investigation of the effect of B. coagulans (Laktovit Forte) on the intestinal dysbiosis syndrome in mice caused by streptomycin against the background of cyclophosphamide-induced cellular immunodeficiency...
April 11, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28392493/the-efficacy-of-probiotics-as-pharmacological-treatment-of-cutaneous-wounds-meta-analysis-of-animal-studies
#11
REVIEW
Christos G Tsiouris, Martha Kelesi, Georgios Vasilopoulos, Ioannis Kalemikerakis, Effie G Papageorgiou
The aim of the current meta-analysis of animal studies was to evaluate the efficacy of probiotics as pharmacological treatment of cutaneous wounds. A systematic electronic literature search was conducted and in total six animal studies which undertake twelve experiments met our inclusion criteria. We used the percentage (%) of wound area at the end of the first week after initial wounding to evaluate the efficacy of the probiotic treatment. The heterogeneity was estimated as statistically significant (p<0...
June 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28386250/means-to-facilitate-the-overcoming-of-gastric-juice-barrier-by-a-therapeutic-staphylococcal-bacteriophage-a5-80
#12
Ryszard Międzybrodzki, Marlena Kłak, Ewa Jończyk-Matysiak, Barbara Bubak, Anna Wójcik, Marta Kaszowska, Beata Weber-Dąbrowska, Małgorzata Łobocka, Andrzej Górski
In this article we compare the efficacy of different pharmacological agents (ranitidine, and omeprazole) to support phage transit from stomach to distal portions of the gastrointestinal tract in rats. We show that a temporal modification of environment in the animal stomach may protect Twort-like therapeutic antistaphylococcal phage A5/80 (from bacteriophage collection of the Hirszfeld Institute of Immunology and Experimental Therapy PAS in Wroclaw, Poland) from the inactivation by gastric juice effectively enough to enable a significant fraction of orally administered A5/80 to pass to the intestine...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28363962/mechanisms-for-pseudoalteromonas-piscicida-induced-killing-of-vibrios-and-other-bacterial-pathogens
#13
Gary P Richards, Michael A Watson, David S Needleman, Joseph Uknalis, E Fidelma Boyd, Johnna P Fay
Pseudoalteromonas piscicida is a Gram-negative gammaproteobacterium found in the marine environment. Three strains of pigmented P. piscicida were isolated from seawater and partially characterized by inhibition studies, electron microscopy, and analysis for proteolytic enzymes. Growth inhibition and death occurred around colonies of P. piscicida on lawns of the naturally occurring marine pathogens Vibrio vulnificus, Vibrio parahaemolyticus, Vibrio cholerae, Photobacterium damselae, and Shewanella algae Inhibition also occurred on lawns of Staphylococcus aureus but not on Escherichia coli O157:H7 or Salmonella enterica serovar Typhimurium...
June 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28165442/antimicrobial-efficacy-of-probiotic-containing-toothpastes-an-in-vitro-evaluation
#14
Miro Klarić, Vjekoslav Mandić, Sanjin Lovrić, Martina Krešić Ćorić, Nikolina Zovko
Most people have heard of the placebo effect, while relatively few have heard of nocebo, even within the circles of medical staff. Placebo effect means positive results by treatment via pharmacological inert substances. In contrast to placebo, by nocebo effect, due to negative beliefs and expectations, opposite results are achieved. Said in a more formal manner, what a sick person expects, unfortunately, he/she most often gets. It is a fact that a high number of medical staff is still uninterested in placebo and nocebo effects, although they would benefit from them...
February 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/28160762/dietary-therapy-in-patients-with-inflammatory-arthritis
#15
Rauli Mäkelä, Heli Mäkilä, Ritva Peltomaa
Context • The exact etiology of rheumatoid disease is currently unknown. Changes in the microbiota of the gastrointestinal (GI) tract, chronic bacterial infection of the upper urinary tract, increased permeability of the GI tract, and food sensitivities have been classified among the factors that may cause or aggravate the disease. Dietary deficiencies also may render patients more susceptible to inflammatory conditions and disorders of the immunological system. Objective • The study intended to determine the effects of a therapy consisting of dietary elimination, dietary supplements, and probiotics, collectively called DDP therapy, which is given either independently or in combination with conventional pharmacological agents...
January 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28129718/response-surface-methodology-a-non-conventional-statistical-tool-to-maximize-the-throughput-of-streptomyces-species-biomass-and-their-bioactive-metabolites
#16
Selvanathan Latha, Govindhan Sivaranjani, Dharumadurai Dhanasekaran
Among diverse actinobacteria, Streptomyces is a renowned ongoing source for the production of a large number of secondary metabolites, furnishing immeasurable pharmacological and biological activities. Hence, to meet the demand of new lead compounds for human and animal use, research is constantly targeting the bioprospecting of Streptomyces. Optimization of media components and physicochemical parameters is a plausible approach for the exploration of intensified production of novel as well as existing bioactive metabolites from various microbes, which is usually achieved by a range of classical techniques including one factor at a time (OFAT)...
January 27, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28120718/nutraceuticals-and-dietary-supplements-to-improve-quality-of-life-and-outcomes-in-heart-failure-patients
#17
Arrigo Fg Cicero, Alessandro Colletti
BACKGROUND: Heart failure (HF) is a complex clinical syndrome that can result from any structural or functional cardiac disorder that impairs the ability of the ventricle to fill or eject blood. It represents a major public health issue, with a prevalence of over 23 million worldwide. The lifetime risk of developing HF is one in five and the most important risk factors identified are ischemic heart disease, hypertension, smoking, obesity and diabetes. Preventive approaches are based on improvements of lifestyle, associated with pharmacological therapy...
January 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27927080/red-ginseng-powder-fermented-with-probiotics-exerts-antidiabetic-effects-in-the-streptozotocin-induced-mouse-diabetes-model
#18
Sun-Hee Jang, Jisang Park, Sae-Hae Kim, Kyung-Min Choi, Eun-Sil Ko, Jeong-Dan Cha, Young-Ran Lee, Hyonseok Jang, Yong-Suk Jang
CONTEXT: Red ginseng (heat-processed Panax ginseng) is a well-known alternative medicine with pharmacological antidiabetic activity. It exerts pharmacological effects through the transformation of saponin into metabolites by the intestinal microbiota. Given that intestinal conditions and intestinal microflora vary among individuals, the pharmacological effects of orally administered red ginseng likely may vary among individuals. OBJECTIVE: To overcome this variation and produce homogeneously effective red ginseng, we evaluated the antidiabetic effects of probiotic-fermented red ginseng in a mouse model...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27763879/a-prospective-descriptive-study-to-assess-the-effect-of-dietary-and-pharmacological-strategies-to-manage-constipation-in-patients-with-a-stoma
#19
Lukasz Krokowicz, Adam Bobkiewicz, Maciej Borejsza-Wysocki, Barbara Kuczynska, Aleksandra Lisowska, Urszula Skowronska-Piekarska, Jacek Paszkowski, Jaroslaw Walkowiak, Michal Drews, Tomasz Banasiewicz
The term constipation with regard to patients with a stoma is defined as impaired bowel movements associated with increased stool consistency or long periods without bowel movements that lead to discomfort, flatulence, and abdominal pain. Information about constipation in patients with a stoma is limited. A prospective, descriptive study was conducted among patients attending ostomy and proctology outpatient clinics in Poznan, Poland between January 2011 and December 2014 to assess the role of dietary and pharmacological strategies in the management of constipation in patients with a stoma...
December 2015: Ostomy/wound Management
https://www.readbyqxmd.com/read/27696378/probiotics-fibre-and-herbal-medicinal-products-for-functional-and-inflammatory-bowel-disorders
#20
REVIEW
Diego Currò, Gianluca Ianiro, Silvia Pecere, Stefano Bibbò, Giovanni Cammarota
Functional bowel disorders (FBD), mainly irritable bowel syndrome (IBS) and functional constipation (FC, also called chronic idiopathic constipation), are very common worldwide. Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, although less common, has a strong impact on patients' quality of life, as well as being highly expensive for our healthcare. A definite cure for those disorders is still yet to come. Over the years, several therapeutic approaches complementary or alternative to traditional pharmacological treatments, including probiotics, prebiotics, synbiotics, fibre and herbal medicinal products, have been investigated for the management of both groups of diseases...
June 2017: British Journal of Pharmacology
keyword
keyword
36271
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"