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Sylvie Grandemange, Elodie Sanchez, Pascale Louis-Plence, Frédéric Tran Mau-Them, Didier Bessis, Christine Coubes, Eric Frouin, Marieke Seyger, Manon Girard, Jacques Puechberty, Valérie Costes, Michel Rodière, Aurélia Carbasse, Eric Jeziorski, Pierre Portales, Guillaume Sarrabay, Michel Mondain, Christian Jorgensen, Florence Apparailly, Esther Hoppenreijs, Isabelle Touitou, David Geneviève
OBJECTIVES: Inflammasomes are multiprotein complexes that sense pathogens and trigger biological mechanisms to control infection. Nucleotide-binding oligomerisation domain-like receptor (NLR) containing a PYRIN domain 1 (NLRP1), NLRP3 and NLRC4 plays a key role in this innate immune system by directly assembling in inflammasomes and regulating inflammation. Mutations in NLRP3 and NLRC4 are linked to hereditary autoinflammatory diseases, whereas polymorphisms in NLRP1 are associated with autoimmune disorders such as vitiligo and rheumatoid arthritis...
July 2017: Annals of the Rheumatic Diseases
Fang-Ping Huang
No abstract text is available yet for this article.
2014: Frontiers in Immunology
Kazimierz Tomczykiewicz, Adam Stepień, Jacek Staszewski
Personage-Turner syndrome or acute brachial radiculitis is rare syndrome. In typical cases it was manifested by strong pain of shoulder region and the weakness of muscles which are supplies by individual nerves or part of brachial plexus and in longer time with atrophy. Aetiology of this disease is unknown, probably on the autoimmuno-inflammatory background. Diagnosis is made on the typical clinical picture and in exclusion many illness with impairment brachial plexus. In presented case the course of disease as well as executed investigations suggested that discopathy could be the reason of paresis, however renewed estimation caused the change of the diagnosis...
August 2011: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Erica Valencic, Elisa Piscianz, Marino Andolina, Alessandro Ventura, Alberto Tommasini
BACKGROUND: Mesenchymal stromal cells (MSC) have been proven to have potent immunosuppressive action and hence have been proposed for the treatment of severe Graft Versus Host Disease. However, in most models, MSC were added at the same time of lymphocyte stimulation, which is quite different from what occurs in vivo. AIMS: To investigate how the timing of lymphocyte activation and the exposure to activation-related cytokines (licensing) can influence the immunosuppressive action of Wharton's jelly stromal cells (WJSC)...
April 2010: Cytotherapy
No abstract text is available yet for this article.
1956: Le Sang
Hirofumi Ochi, Izumi Horiuchi, Norie Araki, Tosifusa Toda, Tomohiro Araki, Kaori Sato, Hiroyuki Murai, Manabu Osoegawa, Takeshi Yamada, Ken Okamura, Tomoaki Ogino, Kiyohisa Mizumoto, Hirohumi Yamashita, Hideyuki Saya, Jun-ichi Kira
Hashimoto's encephalopathy (HE) is a rare autoimmune disease associated with Hashimoto's thyroiditis (HT). To identify the HE-related autoantigens, we developed a human brain proteome map using two-dimensional electrophoresis and applied it to the immuno-screening of brain proteins that react with autoantibodies in HE patients. After sequential MALDI-TOF-MASS analysis, immuno-positive spots of 48 kDa (pI 7.3-7.8) detected from HE patient sera were identified as a novel autoimmuno-antigen, alpha-enolase, harboring several modifications...
September 25, 2002: FEBS Letters
D Gibellini, M C Re, C Ponti, C Celeghini, E Melloni, M La Placa, G Zauli
The regulatory human immunodeficiency virus-1 (HIV-1) Tat protein shows pleiotropic effects on the survival and growth of both HIV-1-infected and uninfected CD4+ T lymphocytes. In this study, we have demonstrated that low concentrations (10 ng/ml) of extracellular Tat protein induce the expression of both c-fos mRNA and protein in serum-starved Jurkat CD4+ lymphoblastoid T cells. Using deletion mutants, we demonstrates that the SRE, CRE and, to a lesser extent, also the SIE domains (all placed in the first 356 bp of c-fos promoter) play a key role in mediating the response to extracellular Tat...
March 2001: British Journal of Haematology
S Huang, G Wu, Z Wang
OBJECTIVE: To investigate the relationship between the anticardiophospholipid antibody (ACA)-positive cases and the poor pregnancy outcomes by observing the immuno-pathomorphology of the placenta. METHODS: 16 cases of ACA-positive placenta (8 normal and 8 poor pregnancy outcomes) were collected as the studied group, and 8 cases of ACA-negative placentas served as the controlled group, and immunofluorescence technique (IFT) was used. RESULTS: In the studied group, the deposits of immuno-complex were found in the cytoplasm of trophoblast and on the walls of villous blood vessels...
February 1998: Zhonghua Fu Chan Ke za Zhi
G Romano, P Michell, C Pacilio, A Giordano
Over the last decade, more than 300 phase I and phase II gene-based clinical trials have been conducted worldwide for the treatment of cancer and monogenic disorders. Lately, these trials have been extended to the treatment of AIDS and, to a lesser extent, cardiovascular diseases. There are 27 currently active gene therapy protocols for the treatment of HIV-1 infection in the USA. Preclinical studies are currently in progress to evaluate the possibility of increasing the number of gene therapy clinical trials for cardiopathies, and of beginning new gene therapy programs for neurologic illnesses, autoimmuno diseases, allergies, regeneration of tissues, and to implement procedures of allogeneic tissues or cell transplantation...
2000: Stem Cells
B D Janković, B M Marković, S Petrović, K Isaković
No abstract text is available yet for this article.
June 1973: European Journal of Immunology
M Miyata, R Matsuyama, M Sto, H Henmi, S Kawada
No abstract text is available yet for this article.
September 1969: Rinsho Byori. the Japanese Journal of Clinical Pathology
M Roget, M Buti, E Allende, M J Rodrigo, J L Rodríguez, R Esteban, J Guardia
The clinical and histological features of the 51 patients affected with chronic autoimmuno hepatitis are analyzed. 65% of them were over 50 years old. 41% were without symptoms. The incidence of systemic symptoms was of 25.5%. 84.3% had antinuclear antibodies superior of 1/40 and 53% had positive LMA. The incidence of HCA and CH was similar. 26.7% of the patients had complications.
January 1989: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
R Y Zheng
A series of 74 cases of delayed polyneuropathy induced by acute middle to serious toxicosis with Methamidophos is analysed. It consists of 49 males and 25 females aged 12 to 45 years, mean age 22.6 years. The clinical features is similar to those of acute polyneuritis in common. The determination of nerve conduction velocity and electromyography show denervation lesions. The recovery cause is from 0.5 to 2 years. The proposal of the five requirements for diagnosis is listed. It is regarded that the pathogenesis of methamidophos-induced delayed polyneuropathy is the toxic effect produced by the "aging" of the phosphoryl-enzyme complex caused by the phosphorylation of a protein neurotoxic esterase (NTE) in the nervous system, and also is the autoimmuno disorder induced by the "aging" of the NTE being probably an immunological basis...
February 1990: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
E Schulz, G Benker, H Bethäuser, L Stempka, M Hüfner
It has become evident in recent years that autoimmune thyroglobulin (Tg) antibodies of Graves disease and Hashimoto's thyroiditis show a restricted epitope repertoire compared to Tg heteroantibodies. We have produced monoclonal antibodies (Mab) against human Tg by the hybridoma technique and the epitope specificity was determined by crossblocking experiments. Six noncrossreactive Mabs were used in a double determinant IRMA system for plasma Tg measurements. Sensitivity of the assays was between 1 and 2 ng/ml, intraassay variation less than 5%...
January 1992: Journal of Endocrinological Investigation
H Heine, G Schaeg, T Nasemann
In Kaposi's sarcoma (K.S.) the regular metabolism between endothelial cell, extracellular matrix and fibrocyte is disturbed. Thereby the composition of the extracellular matrix change and via a feed-back to the CNS and hormonal system in return changes of endothelial cells and fibrocytes appear. Processing of misinformation sum up in transformation of fibrocytes to tumor cells and destruction of endothelial cells. Initial a widening of the interendothelial borders of the capillary bed seem to be of great importance for the pathogenesis of K...
April 27, 1977: Archives for Dermatological Research. Archiv Für Dermatologische Forschung
W Fröscher
The literature dealing with radiation myelopathy is reviewed. The following points are to be noticed:radiation myelopathy is a rare complication in the radiation therapy of extraspinal tumors, nevertheless the number of case reports is increasing during the last years; probably this is due to the increasing use of high energy therapy. Already a cord dose of 1000 rad may be dangerous; with an increasing dose the risk of radiation myelopathy is increasing too. Besides the total dose the incidence of radiation myelopathy depends on the rate of delivery, the over-all time of administration, the size of the individual fraction, the field size, the size of the volume irradiated, the type of irradiation, the use of hyperbaric oxygen and some other special conditions of radiation...
March 1976: Fortschritte der Neurologie, Psychiatrie, und Ihrer Grenzgebiete
M Zirm
Iritis, Iridocyclitis, Uveitis and Scleritis are sometimes caused by rheumatic diseases. Antinuclear antibodies of 64 patients with high ASL O titer and Antinuclear antibodies of 24 patients with negativ ASL O titer were investigated. The results demonstrate the existance of autoantibodies in many cases. These may be caused by autoimmuno-diseases or could be related directly to ophthalmic disorder.
January 1979: Klinische Monatsblätter Für Augenheilkunde
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