Claudia Sciacca, Nunzio Cardullo, Luana Pulvirenti, Gabriele Travagliante, Alessandro D'Urso, Roberta D'Agata, Emanuela Peri, Patrizia Cancemi, Anaëlle Cornu, Denis Deffieux, Laurent Pouységu, Stéphane Quideau, Vera Muccilli
Diabetes mellitus is a metabolic disease characterized by hyperglycemia, which can be counteracted by the inhibition of α-glucosidase (α-Glu) and α-amylase (α-Amy), enzymes responsible for the hydrolysis of carbohydrates. In recent decades, many natural compounds and their bioinspired analogues have been studied as α-Glu and α-Amy inhibitors. However, no studies have been devoted to the evaluation of α-Glu and α-Amy inhibition by the neolignan obovatol (1). In this work, we report the synthesis of 1 and a library of new analogues...
April 24, 2024: Bioorganic Chemistry