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https://www.readbyqxmd.com/read/28108324/the-circle-nephrostomy-tube-an-attractive-nephrostomy-drainage-system-following-complex-percutaneous-nephrolithotomy
#1
Marawan M El Tayeb, Michael S Borofsky, James E Lingeman
OBJECTIVE: To describe our experience with the circle NT (Cook® Medical), a drainage system uniquely designed for use after multiple access PNL. MATERIALS AND METHODS: A retrospective review of 1317 consecutive patients undergoing 1599 PNLs at IU Health Methodist Hospital was performed. All multiple access cases utilizing circle NTs were reviewed and analyzed. The method of insertion of circle NT is demonstrated. RESULTS: A total of 1843 accesses were obtained in 1599 renal units RUs: 380 upper, 129 mid, and 1334 lower...
January 17, 2017: Urology
https://www.readbyqxmd.com/read/28107523/look-into-the-hiv-epidemic-of-gay-community-with-a-socio-cultural-perspective-a-qualitative-study-in-china-2015-2016
#2
Huijing He, Fan Lv, Nanci Nanyi Zhang, Zunyou Wu, Qinghua Liao, Zhanjun Chang, Yi Li, Huifang Xu, Lin OuYang, Xiping Huan, Juan Yang
BACKGROUND: Current Chinese studies continue to view male homosexuality through a disease focused lens which pays limited attention to socio-cultural aspects of sexual behavior and HIV transmission. This qualitative study aimed to investigate how socio-cultural factors influence gay men's sexual beliefs and behaviors in contemporary China, and their implications for HIV epidemic. METHODS AND FINDINGS: Qualitative methodology was used in this study. During 2015-2016, in-depth interviews were conducted with 61 self identified gay men in Jiangxi, Henan, Heilongjiang, Guangdong, Jiangsu provinces and Chongqing municipality of China...
2017: PloS One
https://www.readbyqxmd.com/read/28107477/effects-of-ambient-environmental-factors-on-the-stereotypic-behaviors-of-giant-pandas-ailuropoda-melanoleuca
#3
He Liu, Hejun Duan, Cheng Wang
Stereotypies are commonly observed in zoo animals, and it is necessary to better understand whether ambient environmental factors contribute to stereotypy and how to affect animal welfare in zoo settings. This study investigated the relationships between stereotypic behaviors and environmental factors including ambient temperatures, humidity, light intensity, sound intensity and number of visitors. Seven giant pandas were observed in three indoor enclosures and three outdoor enclosures. Environmental factors were measured for both indoor and outdoor enclosures and the effect they had on stereotypical behaviors was investigated...
2017: PloS One
https://www.readbyqxmd.com/read/28107352/coping-well-with-advanced-cancer-a-serial-qualitative-interview-study-with-patients-and-family-carers
#4
Catherine Walshe, Diane Roberts, Lynda Appleton, Lynn Calman, Paul Large, Mari Lloyd-Williams, Gunn Grande
OBJECTIVES: To understand successful strategies used by people to cope well when living with advanced cancer; to explore how professionals can support effective coping strategies; to understand how to support development of effective coping strategies for patients and family carers. DESIGN: Qualitative serial (4-12 week intervals) interview study with people with advanced cancer and their informal carers followed by focus groups. The iterative design had a novel focus on positive coping strategies...
2017: PloS One
https://www.readbyqxmd.com/read/28107190/radiosynthesis-and-validation-of-%C3%A2-18f-3-fluoro-2-hydroxypropionate-18f-flac-as-a-pet-tracer-of-lactate-to-monitor-mct1-dependent-lactate-uptake-in-tumors
#5
Vincent F Van Hée, Daniel Labar, Gwenaël Dehon, Debora Grasso, Vincent Grégoire, Giulio G Muccioli, Raphaël Frédérick, Pierre Sonveaux
Cancers develop metabolic strategies to cope with their microenvironment often characterized by hypoxia, limited nutrient bioavailability and exposure to anticancer treatments. Among these strategies, the metabolic symbiosis based on the exchange of lactate between hypoxic/glycolytic cancer cells that convert glucose to lactate and oxidative cancer cells that preferentially use lactate as an oxidative fuel optimizes the bioavailability of glucose to hypoxic cancer cells. This metabolic cooperation has been described in various human cancers and can provide resistance to anti-angiogenic therapies...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28106881/phylogenomics-of-rhodobacteraceae-reveals-evolutionary-adaptation-to-marine-and-non-marine-habitats
#6
Meinhard Simon, Carmen Scheuner, Jan P Meier-Kolthoff, Thorsten Brinkhoff, Irene Wagner-Döbler, Marcus Ulbrich, Hans-Peter Klenk, Dietmar Schomburg, Jörn Petersen, Markus Göker
Marine Rhodobacteraceae (Alphaproteobacteria) are key players of biogeochemical cycling, comprise up to 30% of bacterial communities in pelagic environments and are often mutualists of eukaryotes. As 'Roseobacter clade', these 'roseobacters' are assumed to be monophyletic, but non-marine Rhodobacteraceae have not yet been included in phylogenomic analyses. Therefore, we analysed 106 genome sequences, particularly emphasizing gene sampling and its effect on phylogenetic stability, and investigated relationships between marine versus non-marine habitat, evolutionary origin and genomic adaptations...
January 20, 2017: ISME Journal
https://www.readbyqxmd.com/read/28106793/hybrid-intelligent-system-to-perform-fault-detection-on-bis-sensor-during-surgeries
#7
José-Luis Casteleiro-Roca, José Luis Calvo-Rolle, Juan Albino Méndez Pérez, Nieves Roqueñí Gutiérrez, Francisco Javier de Cos Juez
This paper presents a new fault detection system in hypnotic sensors used for general anesthesia during surgery. Drug infusion during surgery is based on information received from patient monitoring devices; accordingly, faults in sensor devices can put patient safety at risk. Our research offers a solution to cope with these undesirable scenarios. We focus on the anesthesia process using intravenous propofol as the hypnotic drug and employing a Bispectral Index (BIS(TM)) monitor to estimate the patient's unconsciousness level...
January 18, 2017: Sensors
https://www.readbyqxmd.com/read/28106766/the-anti-oxidant-defense-system-of-the-marine-polar-ciliate-euplotes-nobilii-characterization-of-the-msrb-gene-family
#8
Francesca Ricci, Federico M Lauro, Joseph J Grzymski, Robert Read, Rigers Bakiu, Gianfranco Santovito, Pierangelo Luporini, Adriana Vallesi
Organisms living in polar waters must cope with an extremely stressful environment dominated by freezing temperatures, high oxygen concentrations and UV radiation. To shed light on the genetic mechanisms on which the polar marine ciliate, Euplotes nobilii, relies to effectively cope with the oxidative stress, attention was focused on methionine sulfoxide reductases which repair proteins with oxidized methionines. A family of four structurally distinct MsrB genes, encoding enzymes specific for the reduction of the methionine-sulfoxide R-forms, were identified from a draft of the E...
January 18, 2017: Biology
https://www.readbyqxmd.com/read/28106669/translational-studies-identify-long-term-impact-of-prior-neonatal-pain-experience
#9
Suellen M Walker
Pain sensitivity and risk of chronic pain can be influenced by past experience. Childhood stress/adversity has been associated with chronic pain, mood disorders, and altered disease vulnerability decades later. As the rate of preterm birth and survival at earlier gestational ages increases, and advances in peri-operative care and surgery allow more complex surgical interventions to be performed in neonates, evaluation of treatment 'success' must extend beyond acute morbidity and mortality to encompass effects on subsequent neurodevelopmental outcome, and also sensory, cognitive and behavioral responses to pain in later life...
January 12, 2017: Pain
https://www.readbyqxmd.com/read/28106572/training-in-positivity-for-stroke-a-qualitative-study-of-acceptability-of-use-of-positive-mental-training-posmt-as-a-tool-to-assist-stroke-survivors-with-post-stroke-psychological-problems-and-in-coping-with-rehabilitation
#10
Nahal Mavaddat, Sheila Ross, Alastair Dobbin, Kate Williams, Jonathan Graffy, Jonathan Mant
BACKGROUND: Post-stroke psychological problems predict poor recovery, while positive affect enables patients to focus on rehabilitation and may improve functional outcomes. Positive Mental Training (PosMT), a guided self-help audio shows promise as a tool in promoting positivity, optimism and resilience. OBJECTIVE: To assess acceptability of training in positivity with PosMT for prevention and management of post-stroke psychological problems and to help with coping with rehabilitation...
January 18, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28106559/abca1-deficiency-affects-basal-cognitive-deficits-and-dendritic-density-in-mice
#11
Nicholas F Fitz, Alexis Y Carter, Victor Tapias, Emilie L Castranio, Ravindra Kodali, Iliya Lefterov, Radosveta Koldamova
ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoproteins and regulates the generation of high density lipoproteins. Previously, we have shown that lack of Abca1 significantly increases amyloid deposition and cognitive deficits in Alzheimer's disease model mice expressing human amyloid-β protein precursor (APP). The goal of this study was to determine if ABCA1 plays a role in memory deficits caused by amyloid-β (Aβ) oligomers and examine neurite architecture of pyramidal hippocampal neurons...
January 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28105918/mirnacle-machine-learning-with-smote-and-random-forest-for-improving-selectivity-in-pre-mirna-ab-initio-prediction
#12
Yuri Bento Marques, Alcione de Paiva Oliveira, Ana Tereza Ribeiro Vasconcelos, Fabio Ribeiro Cerqueira
BACKGROUND: MicroRNAs (miRNAs) are key gene expression regulators in plants and animals. Therefore, miRNAs are involved in several biological processes, making the study of these molecules one of the most relevant topics of molecular biology nowadays. However, characterizing miRNAs in vivo is still a complex task. As a consequence, in silico methods have been developed to predict miRNA loci. A common ab initio strategy to find miRNAs in genomic data is to search for sequences that can fold into the typical hairpin structure of miRNA precursors (pre-miRNAs)...
December 15, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28105908/degreecox-a-network-based-regularization-method-for-survival-analysis
#13
André Veríssimo, Arlindo Limede Oliveira, Marie-France Sagot, Susana Vinga
BACKGROUND: Modeling survival oncological data has become a major challenge as the increase in the amount of molecular information nowadays available means that the number of features greatly exceeds the number of observations. One possible solution to cope with this dimensionality problem is the use of additional constraints in the cost function optimization. LASSO and other sparsity methods have thus already been successfully applied with such idea. Although this leads to more interpretable models, these methods still do not fully profit from the relations between the features, specially when these can be represented through graphs...
December 13, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28105371/unfolding-anti-tumor-immunity-er-stress-responses-sculpt-tolerogenic-myeloid-cells-in-cancer
#14
REVIEW
Juan R Cubillos-Ruiz, Eslam Mohamed, Paulo C Rodriguez
Established tumors build a stressful and hostile microenvironment that blocks the development of protective innate and adaptive immune responses. Different subsets of immunoregulatory myeloid populations, including dendritic cells, myeloid-derived suppressor cells (MDSCs) and macrophages, accumulate in the stressed tumor milieu and represent a major impediment to the success of various forms of cancer immunotherapy. Specific conditions and factors within tumor masses, including hypoxia, nutrient starvation, low pH, and increased levels of free radicals, provoke a state of "endoplasmic reticulum (ER) stress" in both malignant cells and infiltrating myeloid cells...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28104889/a-peptide-hormone-required-for-casparian-strip-diffusion-barrier-formation-in-arabidopsis-roots
#15
Takuya Nakayama, Hidefumi Shinohara, Mina Tanaka, Koki Baba, Mari Ogawa-Ohnishi, Yoshikatsu Matsubayashi
Plants achieve mineral ion homeostasis by means of a hydrophobic barrier on endodermal cells called the Casparian strip, which restricts lateral diffusion of ions between the root vascular bundles and the soil. We identified a family of sulfated peptides required for contiguous Casparian strip formation in Arabidopsis roots. These peptide hormones, which we named Casparian strip integrity factor 1 (CIF1) and CIF2, are expressed in the root stele and specifically bind the endodermis-expressed leucine-rich repeat receptor kinase GASSHO1 (GSO1)/SCHENGEN3 and its homolog, GSO2...
January 20, 2017: Science
https://www.readbyqxmd.com/read/28104580/leveraging-electronic-health-care-record-information-to-measure-pressure-ulcer-risk-in-veterans-with-spinal-cord-injury-a-longitudinal-study-protocol
#16
Stephen L Luther, Susan S Thomason, Sunil Sabharwal, Dezon K Finch, James McCart, Peter Toyinbo, Lina Bouayad, Michael E Matheny, Glenn T Gobbel, Gail Powell-Cope
BACKGROUND: Pressure ulcers (PrUs) are a frequent, serious, and costly complication for veterans with spinal cord injury (SCI). The health care team should periodically identify PrU risk, although there is no tool in the literature that has been found to be reliable, valid, and sensitive enough to assess risk in this vulnerable population. OBJECTIVE: The immediate goal is to develop a risk assessment model that validly estimates the probability of developing a PrU...
January 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28104230/first-evidence-of-persistent-organic-contaminants-as-potential-anthropogenic-stressors-in-the-barndoor-skate-dipturus-laevis
#17
Kady Lyons, Douglas H Adams
Although exploited populations of elasmobranchs may be able to recover from fishing pressure, there is little information regarding the Barndoor Skate's ability to cope with other anthropogenic stressors such as organic contaminants (OCs). Legacy OCs were measured in liver, muscle and ova from fourteen Barndoor Skates with mature skates having significantly greater mean concentrations of OCs than immature skates, demonstrating bioaccumulation with age. Using Toxic Equivalency Factors, skates were found to have levels of PCBs that have been shown to elicit negative physiological responses in other fishes and these results highlight the need for future studies to investigate the potential impacts that bioaccumulated organic contaminants have on the recovery and conservation of this vulnerable species...
January 16, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28104056/psychological-distress-in-jordanian-parents-of-children-with-autism-spectrum-disorder-the-role-of-positive-reappraisal-coping
#18
Ahmad Rayan, Muayyad Ahmad
BACKGROUND: Parents of children with autism spectrum disorder (ASD) frequently report poor psychological well-being. Positive reappraisal coping (PRC) is a coping strategy which offers a protective effect from anxiety and depression. However, the association between PRC and the psychological distress in parents of children with ASD has yet to be established. AIM: This study examines the association between PRC and the psychological distress in parents of children with ASD...
February 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28103840/more-than-eight-in-every-nineteen-inmates-were-living-with-depression-at-prisons-of-northwest-amhara-regional-state-ethiopia-a-cross-sectional-study-design
#19
Teresa Kisi Beyen, Abel Fikadu Dadi, Berihun Assefa Dachew, Niguse Yigzaw Muluneh, Telake Azale Bisetegn
BACKGROUND: Mental health is the greatest challenges for the current and future generations. Worldwide, out of the 66 million people suffering from depression; majority (85%) were from low and middle income countries. The prevalence was more common among the prisons population than the community. However, a worldwide consideration given to the problems is very low, particularly for prisoners. METHODS: To assess level of depression and associated factors among prisoners in prisons of Northwest Amhara Regional State, Ethiopia, Institutional based cross sectional study was employed on 727 prisoners selected by multistage random sampling from three prisons of northwest Amhara...
January 19, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28103786/crh-receptor-signalling-potential-roles-in-pathophysiology
#20
Styliani Ourailidou, Dimitris Grammatopoulos
To maintain homeostatic equilibrium, living organisms have evolved complex adaptation systems that control an array of behavioural, autonomic, neuroendocrine and immune responses. One of the important switches The master switch of this system is the hypothalamic hormone corticotropin-releasing hormone (CRH), which together with a family of related peptides (urocortins, UCNs) orchestrate stress-coping responses that reinstate homeostasis. Persistent disturbances in the homeostatic equilibrium either due to inadequate or persistently uncontrolled responses have been associated with pathogenic mechanisms of disease...
January 10, 2017: Current Molecular Pharmacology
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