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https://www.readbyqxmd.com/read/29166383/prematurity-disrupts-glomeruli-development-while-prematurity-and-hyperglycemia-lead-to-altered-nephron-maturation-and-increased-oxidative-stress-in-newborn-baboons
#1
Danielle A Callaway, Lisa L McGill-Vargas, Amy Quinn, Jasmine L Jordan, Lauryn A Winter, Diana Anzueto, Edward J Dick, Cynthia L Blanco
BACKGROUND: Premature birth occurs when nephrogenesis is incomplete and has been linked to increased renal pathologies in the adult. Metabolic factors complicating preterm birth may have additional consequences for kidney development. Here, we evaluated the effects of prematurity and hyperglycemia on nephrogenesis in premature baboons when compared to term animals. METHODS: Baboons were delivered prematurely (67% gestation; n=9) or at term (n=7) and survived 2-4 weeks...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29166380/food-and-nutrient-intakes-in-young-adults-born-preterm
#2
Hanna-Maria Matinolli, Satu Männistö, Marika Sipola-Leppänen, Marjaana Tikanmäki, Kati Heinonen, Johan G Eriksson, Dieter Wolke, Aulikki Lano, Marjo-Riitta Järvelin, Marja Vääräsmäki, Katri Räikkönen, Eero Kajantie
BACKGROUND: Adults born preterm have higher levels of cardiometabolic risk factors than their term-born peers. Studies have suggested that at least those born smallest eat less healthily. We examined the association between early (<34 weeks) and late (34 to 36 weeks) preterm birth and diet and food preferences in adult age. METHODS: Participants of two cohort studies located in Finland completed a validated food frequency questionnaire(FFQ) at age 24y to assess their usual diet and the adherence to healthy eating guidelines by using a recommended diet index(RDI)...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29166182/increasing-confidence-and-ability-in-implementing-kangaroo-mother-care-method-among-young-mothers
#3
Eleni Kenanga Purbasary, Yeni Rustina, Tri Budiarti
Mothers giving birth to low birth weight babies (LBWBs) have low confidence in caring for their babies because they are often still young and may lack the knowledge, experience, and ability to care for the baby. This research aims to determine the effect of education about kangaroo mother care (KMC) on the confidence and ability of young mothers to implement KMC. The research methodology used was a controlled-random experimental approach with pre- and post-test equivalent groups of 13 mothers and their LBWBs in the intervention group and 13 mothers and their LBWBs in the control group...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29165697/lifting-and-pregnancy-outcomes-feasibility-of-a-randomized-controlled-trial
#4
E Kwegyir-Afful, J Verbeek, L Aziato, J D Seffah, K Vehviläinen-Julkunen, K Räsänen
Background: The highest incidence of preterm birth (18%) occurs in Africa but the causes are largely unknown. Some studies have reported adverse effects of maternal physical exertion on birth outcomes. A randomized controlled trial (RCT) is proposed to determine the effectiveness of an intervention reducing lifting and carrying in pregnant women in reducing preterm birth and low birthweight. Aims: To test the feasibility and acceptability of the proposed lift-less intervention RCT...
November 19, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29165679/a-two-state-model-of-tree-evolution-and-its-applications-to-alu-retrotransposition
#5
Niema Moshiri, Siavash Mirarab
Models of tree evolution have mostly focused on capturing the cladogenesis processes behind speciation. Processes that derive the evolution of genomic elements, such as repeats, are not necessarily captured by these existing models. In this paper, we design a model of tree evolution that we call the dual-birth model, and we show how it can be useful in studying the evolution of short Alu repeats found in the human genome in abundance. The dual-birth model extends the traditional birth- only model to have two rates of propagation, one for active nodes that propagate often, and another for inactive nodes, that with a lower rate, activate and start propagating...
November 20, 2017: Systematic Biology
https://www.readbyqxmd.com/read/29165677/being-born-too-small-and-too-early-may-alter-sleep-in-childhood
#6
Stephanie R Yiallourou, Bianca C Arena, Euan M Wallace, Alexsandria Odoi, Samantha Hollis, Aidan Weichard, Rosemary S C Horne
Study Objectives: Fetal growth restriction (FGR) occurs in up to 10% of pregnancies and is associated with increased risk of prematurity and neurodevelopmental impairment. FGR also alters sleep state distribution in utero and maturation in infancy. Currently, limited data on the long-term associations of FGR and childhood sleep exist. Accordingly, we assessed the associations between preterm birth and FGR and sleep in children aged 5-12 years. Methods: 17 children born preterm and FGR, 15 children born preterm but appropriately grown (AGA) and 20 term AGA children (controls) were studied using overnight polysomnography...
November 20, 2017: Sleep
https://www.readbyqxmd.com/read/29165629/morbidity-mortality-and-socioeconomics-in-females-with-46-xy-disorders-of-sex-development-a-nationwide-study
#7
Agnethe Berglund, Trine H Johannsen, Kirstine Stochholm, Mette H Viuff, Jens Fedder, Katharina M Main, Claus H Gravholt
Context: Little is known about long-term health outcomes in phenotypic females with 46,XY disorders of sex development (XY females) and the socioeconomic profile is not described in detail. Objective: To describe morbidity, mortality and socioeconomic status in XY females in a comparison to the general population. Design: A nationwide registry study with complete follow-up. Setting: A uniform public health care system...
November 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29165598/fetal-growth-and-birth-anthropometrics-in-metformin-exposed-offspring-born-to-mothers-with-pcos
#8
Anna Hjorth-Hansen, Øyvind Salvesen, Liv Guro Engen Hanem, Torbjørn Eggebø, Kjell Å Salvesen, Eszter Vanky, Rønnaug Ødegård
Context: Metformin is used in attempt to reduce pregnancy complications associated with polycystic ovary syndrome (PCOS). Little is known about the metformin impact on fetal development and growth. Objectives: Exploring the metformin effect vs. placebo on fetal growth and birth anthropometrics in PCOS-offspring compared to a reference population in relation to maternal BMI. Design: Post-hoc analysis of an RCT. Setting: Double-blind, placebo-controlled, multicenter study...
November 17, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29165555/prenatal-exposure-to-di-2-ethylhexyl-phthalate-dehp-disrupts-ovarian-function-in-a-transgenerational-manner-in-female-mice
#9
Saniya Rattan, Emily Brehm, Liying Gao, Sarah Niermann, Jodi A Flaws
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer found in polyvinyl chloride products such as vinyl flooring, plastic food containers, medical devices, and children's toys. DEHP is a ubiquitous environmental contaminant and is a known endocrine disrupting chemical. Little is known about the effects of prenatal DEHP exposure on the ovary and whether effects occur in subsequent generations. Thus, we tested the hypothesis that prenatal exposure to DEHP disrupts ovarian functions in the F1, F2, and F3 generations of female mice...
November 20, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29164953/unintended-birth-and-children-s-long-term-mental-health
#10
Jessica Houston Su
Research has examined the proximate effects of unintended birth on infants and young children, but we know relatively little about the longer-term effects. Given that unintended birth is associated with several childhood risk factors, it might set the stage for poor mental health in adulthood. Drawing on rich intergenerational survey data from the National Longitudinal Survey of Youth, 1979 ( N = 3,742), this study used a variety of statistical techniques to examine whether maternal pregnancy intentions are associated with children's depressive symptoms during early adulthood...
September 2017: Journal of Health and Social Behavior
https://www.readbyqxmd.com/read/29164825/autism-spectrum-disorder-and-birth-spacing-findings-from-the-study-to-explore-early-development-seed
#11
Laura A Schieve, Lin H Tian, Carolyn Drews-Botsch, Gayle C Windham, Craig Newschaffer, Julie L Daniels, Li-Ching Lee, Lisa A Croen, M Danielle Fallin
Previous studies of autism spectrum disorder (ASD) and birth spacing had limitations; few examined phenotypic case subtypes or explored underlying mechanisms for associations and none assessed whether other (non-ASD) developmental disabilities (DDs) were associated with birth spacing. We assessed associations between inter-pregnancy interval (IPI) and both ASD and other DDs using data from the Study to Explore Early Development, a multi-site case-control study with rigorous case-finding and case-classification methods and detailed data collection on maternal reproductive history...
November 22, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29164811/congenital-heart-defects-in-ivf-icsi-pregnancy-a-systematic-review-and-meta-analysis
#12
REVIEW
Veronica Giorgione, Fabio Parazzini, Vlasta Fesslova, Sonia Cipriani, Massimo Candiani, Annalisa Inversetti, Cristina Sigismondi, Francesca Tiberio, Paolo Cavoretto
OBJECTIVE: There is no consensus in current practice guidelines whether IVF/ICSI conception represents an indication for performing a fetal echocardiogram. The aim of the study is to assess whether CHD occurs more often with the use of in-vitro-fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) techniques as compared to spontaneous pregnancies. METHODS: A systematic search for studies in PubMed/MEDLINE, Embase and Scopus from inception to September 2017 was conducted...
November 22, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29163643/persistent-bovine-viral-diarrhea-virus-bvdv-infection-in-cattle-herds
#13
REVIEW
A Khodakaram-Tafti, G H Farjanikish
Bovine viral diarrhea virus (BVDV) is a significant pathogen associated with gastrointestinal, respiratory, and reproductive diseases of cattle worldwide. It causes continuous economic losses to the cattle industry primarily due to decreased reproductive performance. The ability of virus to cross the placenta during early pregnancy can result in the birth of persistently infected (PI) calves. Persistently infected animals are generally much more efficient transmitters of BVDV than transiently or acutely infected animals because they are capable of shedding large quantities of virus throughout their lives and are considered the primary reservoirs for BVDV...
2017: Iranian journal of veterinary research
https://www.readbyqxmd.com/read/29163369/preconception-prebiotic-and-sitagliptin-treatment-in-obese-rats-affects-pregnancy-outcomes-and-offspring-microbiota-adiposity-and-glycemia
#14
Carol A Dennison, Amanda J Eslinger, Raylene A Reimer
Maternal obesity is associated with increased risk of pregnancy complications and greater risk of obesity in offspring, but studies designed to examine preconception weight loss are limited. The objective of this study was to determine if a combined dietary [oligofructose (OFS)] and pharmacological (sitagliptin) preconception intervention could mitigate poor pregnancy outcomes associated with maternal obesity and improve offspring metabolic health and gut microbiota composition. Diet-induced obese female Sprague-Dawley rats were randomized to one of four intervention groups for 8 weeks: (1) Obese-Control (consumed control diet during intervention); (2) Obese-OFS (10% OFS diet); (3) Obese-S (sitagliptin drug); (4) Obese-OFS + S (combination treatment)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29163361/girls-with-a-history-of-premature-adrenarche-have-advanced-growth-and-pubertal-development-at-the-age-of-12-years
#15
Jani Liimatta, Pauliina Utriainen, Raimo Voutilainen, Jarmo Jääskeläinen
Background: Premature adrenarche (PA) has been linked to early thelarche and menarche, but longitudinal data on growth and pubertal development after PA are insufficient. Methods: Growth and pubertal development of mostly full-term and appropriate for gestational age-born 43 PA (36 girls) and 63 control children (52 girls) were analyzed prospectively. Children examined first at the mean age of 7.6 years were reexamined at the mean age of 12.0 years. Results: The PA girls but not the boys were taller and had higher body mass index (BMI) than the controls...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29162726/foxj1a-is-expressed-in-ependymal-precursors-controls-central-canal-position-and-is-activated-in-new-ependymal-cells-during-regeneration-in-zebrafish
#16
Ana Ribeiro, Joana F Monteiro, Ana C Certal, Ana M Cristovão, Leonor Saúde
Zebrafish are able to regenerate the spinal cord and recover motor and sensory functions upon severe injury, through the activation of cells located at the ependymal canal. Here, we show that cells surrounding the ependymal canal in the adult zebrafish spinal cord express Foxj1a. We demonstrate that ependymal cells express Foxj1a from their birth in the embryonic neural tube and that Foxj1a activity is required for the final positioning of the ependymal canal. We also show that in response to spinal cord injury, Foxj1a ependymal cells actively proliferate and contribute to the restoration of the spinal cord structure...
November 2017: Open Biology
https://www.readbyqxmd.com/read/29162628/etiopathogenesis-and-pharmacological-prevention-of-a-type-2-diabetes-model-in-male-mice
#17
Alberto Loizzo, Santi M Spampinato, Gabriele Campana, Stefano Loizzo
We describe a stress-derived type-2 diabetes model in male mice, and formulate new hypotheses on how the model was induced, how diabetes-like alterations were prevented through specific pharmacological treatments, and how its possible neuroendocrine pathogenesis could be hypothesized. Pregnant females arrived in our laboratory on their 14th day of conceptional age. After birth, control mice never showed any apparent behavioral-metabolic-endocrine alterations. However, application of postnatal stress (brief mother deprivation, plus sham injection, daily from birth to weaning), was followed in adult male mice by two series of diabetes-like alterations...
November 21, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29162626/identification-of-isthmin-1-as-a-novel-clefting-and-craniofacial-patterning-gene-in-humans
#18
Lisa A Lansdon, Benjamin W Darbro, Aline L Petrin, Alissa M Hulstrand, Jennifer M Standley, Rachel B Brouillette, Abby Long, M Adela Mansilla, Robert A Cornell, Jeffery C Murray, Douglas W Houston, J Robert Manak
Orofacial clefts are one of the most common birth defects, affecting 1-2 per 1000 births, and have a complex etiology. High-resolution array-based comparative genomic hybridization has increased the ability to detect copy number variants that can be causative for complex diseases such as cleft lip and/or palate. Utilizing this technique on 97 non-syndromic cleft lip and palate cases and 43 cases with cleft palate only, we identified a heterozygous deletion of Isthmin 1 in one affected case, as well as a deletion in a second case which removes putative 3' regulatory information...
November 21, 2017: Genetics
https://www.readbyqxmd.com/read/29162597/prevalence-and-clinical-profile-of-microcephaly-in-south-america-pre-zika-2005-14-prevalence-and-case-control-study
#19
Iêda M Orioli, Helen Dolk, Jorge S Lopez-Camelo, Daniel Mattos, Fernando A Poletta, Maria G Dutra, Flavia M Carvalho, Eduardo E Castilla
Objective To describe the prevalence and clinical spectrum of microcephaly in South America for the period 2005-14, before the start of the Zika epidemic in 2015, as a baseline for future surveillance as the Zika epidemic spreads and as other infectious causes may emerge in future.Design Prevalence and case-control study.Data sources ECLAMC (Latin American Collaborative Study of Congenital Malformations) database derived from 107 hospitals in 10 South American countries, 2005 to 2014. Data on microcephaly cases, four non-malformed controls per case, and all hospital births (all births for hospital based prevalence, resident within municipality for population based prevalence)...
November 21, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29162493/outbreak-of-gentamicin-resistant-meticillin-susceptible-staphlococcus-aureus-on-a-neonatal-unit
#20
Sahar Eldirdiri, Jennifer Lee, Ann Jack, Alison Wright, Alison Findlay, Gabby Phillips
BACKGROUND: This report describes an outbreak of gentamicin-resistant meticillin-resistant Staphylococcus aureus (GR MSSA) which occurred on a 21-bed neonatal unit (NNU) in Ninewells Hospital, Dundee, Scotland. METHODS: An outbreak investigation was triggered by two new GR MSSA isolates from babies admitted directly to the unit who had acquired this organism during their stay. Data on MSSA cases and antibiograms of patient isolates were flagged as an alert and microbiology records trawled to detect previous cases...
November 18, 2017: Journal of Hospital Infection
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