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https://www.readbyqxmd.com/read/28449286/full-dilatation-cesarean-section-a-risk-factor-for-recurrent-second-trimester-loss-and-preterm-birth
#1
Helena A Watson, Jenny Carter, Anna L David, Paul T Seed, Andrew H Shennan
INTRODUCTION: A previous cesarean section at full dilatation (FDCS) is a risk factor for preterm birth. To provide insight on the risk to subsequent pregnancies, this cohort study compares the outcomes of pregnant women with a previous preterm birth associated either with a prior FDCS or a prior term vaginal delivery. MATERIAL AND METHODS: We identified women attending two inner-city preterm surveillance clinics (Guy's and St Thomas Hospital and University College London Hospital, London, UK) who had a spontaneous late miscarriage (14(+0) -23(+6) weeks) or sPTB (<37weeks) following a term pregnancy, and then a further pregnancy for analysis...
April 27, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28449133/maternal-alcohol-use-during-pregnancy-and-offspring-attention-deficit-hyperactivity-disorder-adhd-a-prospective-sibling-control-study
#2
Espen Moen Eilertsen, Line C Gjerde, Ted Reichborn-Kjennerud, Ragnhild E Ørstavik, Gun Peggy Knudsen, Camilla Stoltenberg, Nikolai Czajkowski, Espen Røysamb, Kenneth S Kendler, Eivind Ystrom
Background: Maternal alcohol use during pregnancy has repeatedly been associated with development of attention-deficit hyperactivity disorder (ADHD) in the offspring. It is, however not known whether this reflects a direct casual intra-uterine effect or a non-causal relationship due to confounding. We used three different approaches to control for measured and unmeasured confounding: statistical adjustment for covariates, negative control comparison against maternal pre-pregnancy alcohol use, and comparison among differentially exposed siblings...
April 24, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28448910/exposure-to-2-2-4-4-tetrabromodiphenyl-ether-at-late-gestation-modulates-placental-signaling-molecules-in-the-mouse-model
#3
Yun Zhu, Yan Qin Tan, Lai K Leung
Polybrominated diphenyl ethers (PBDEs) are flame retardants generally employed in manufacturing household items. Surface water may remove and carry these chemicals to the drainage upon disposal of the items, and ultimately the chemicals enter our food chain. 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) is a PBDE congener commonly found in contaminated seafood. The placenta is the site of nutrient exchange and is responsible for reproductive hormone secretion during pregnancy. In the present study, pregnant ICR mice were given p...
April 22, 2017: Chemosphere
https://www.readbyqxmd.com/read/28448569/dynamics-and-complexity-of-body-temperature-in-preterm-infants-nursed-in-incubators
#4
Kerstin Jost, Isabelle Pramana, Edgar Delgado-Eckert, Nitin Kumar, Alexandre N Datta, Urs Frey, Sven M Schulzke
BACKGROUND: Poor control of body temperature is associated with mortality and major morbidity in preterm infants. We aimed to quantify its dynamics and complexity to evaluate whether indices from fluctuation analyses of temperature time series obtained within the first five days of life are associated with gestational age (GA) and body size at birth, and presence and severity of typical comorbidities of preterm birth. METHODS: We recorded 3h-time series of body temperature using a skin electrode in incubator-nursed preterm infants...
2017: PloS One
https://www.readbyqxmd.com/read/28447764/sevoflurane-anesthesia-in-pregnant-rats-negatively-affects-nerve-function-in-offspring-potentially-via-inhibition-of-the-wnt-%C3%AE-catenin-pathway
#5
Yiyao Wang, Yu Li, Qunzhi Xing, Xuechan G Han, Xu Dong, Yiping Lu, Mintao Zhou
Due to the rapid development of medical technology used to perform intrauterine procedures during pregnancy, the number of patients receiving fetal surgery under general anesthesia is increasing. The aim of the present study was to determine the effects of anesthetics on the offspring of rats, and to identify the potential mechanisms underlying these effects. On day 14 of pregnancy, Sprague‑Dawley rats were equally divided into the following 3 groups (n=9): Control group (n=3), 3% sevoflurane group (n=3) and 4% sevoflurane group (n=3)...
March 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447505/does-pituitary-suppression-affect-live-birth-rate-in-women-with-congenital-hypogonadotrophic-hypogonadism-undergoing-intra-cytoplasmic-sperm-injection-a-multicenter-cohort-study
#6
Sezcan Mumusoglu, Baris Ata, Volkan Turan, Berfu Demir, Inci Kahyaoglu, Kiper Aslan, Ayse Seyhan Ata, Bulent Yilmaz, Kayhan Yakin, Berrin Avci, Gurkan Uncu, Gurkan Bozdag
In this retrospective multicenter cohort study, women with congenital hypogonadotrophic hypogonadism (CHH) (n = 57) who underwent intra-cytoplasmic sperm injection in-between 2010-2014 were compared to age-matched controls with tubal factor infertility (n = 114) to assess ovarian stimulation cycle and pregnancy outcomes. Live birth rates (LBRs) per started cycle were 31.6 and 24.6% in CHH and controls groups, respectively (p = 0.36). Comparable success rates were also confirmed with the logistic regression analysis (OR: 1...
April 27, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28447275/risk-factors-for-shoulder-dystocia-the-impact-of-mother-s-race-and-ethnicity
#7
Jennifer Gaudet Hefele, Palmira Santos, Grant Ritter, Neha Varma, Ann Hendrich
Shoulder dystocia is a rare but severe birth trauma where the neonate's shoulders fail to deliver after delivery of the head. Failure to deliver the shoulders quickly can lead to severe, long-term injury to the infant, including nerve injury, skeletal fractures, and potentially death. This observational study examined shoulder dystocia risk factors by race and ethnicity using a sample of 19,236 pregnant women who presented for labor and delivery from July 1, 2010 until June 30, 2013 at five locations. Multivariate analyses were used to identify risk factors associated with shoulder dystocia occurrence in racial/ethnic groups with high incidence rates...
April 26, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28446592/bim-gene-dosage-is-critical-in-modulating-nephron-progenitor-survival-in-the-absence-of-micrornas-during-kidney-development
#8
Débora M Cerqueira, Andrew J Bodnar, Yu Leng Phua, Rachel Freer, Shelby L Hemker, Loren D Walensky, Neil A Hukriede, Jacqueline Ho
Low nephron endowment at birth has been associated with an increased risk for developing hypertension and chronic kidney disease. We demonstrated in an earlier study that conditional deletion of the miRNA-processing enzyme Dicer from nephron progenitors results in premature depletion of the progenitors and increased expression of the proapoptotic protein Bim (also known as Bcl-2L11). In this study, we generated a compound mouse model with conditional deletion of both Dicer and Bim, to determine the biologic significance of increased Bim expression in Dicer-deficient nephron progenitors...
April 26, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28446046/use-of-embryo-culture-supernatant-to-improve-clinical-outcomes-in-assisted-reproductive-technology-a-systematic-review-and-meta-analysis
#9
Mohan Shashikant Kamath, Mariano Mascarenhas, Richard Kirubakaran, Raju Nair, Abhijit Kulkarni
We planned a systematic review and meta-analysis of randomized clinical trials (RCTs) to examine the best available evidence regarding the intrauterine instillation of embryo culture supernatant prior to embryo transfer in ART. The outcomes were: (i) live birth; (ii) clinical pregnancy; (iii) multiple pregnancy; and (iv) miscarriage rates. Five RCTs were considered eligible and available for qualitative synthesis. Due to clinical heterogeneity, results from only two trials were combined for the meta-analysis...
April 26, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28445843/health-and-income-inequalities-in-europe-what-is-the-role-of-circumstances
#10
M Pasqualini, D Lanari, L Minelli, L Pieroni, L Salmasi
Equality of opportunity theories distinguish between inequalities due to individual effort and those due to external circumstances. Recent research has shown that half of the variability in income of World population was determined by country of birth and income distribution. Since health and income are generally strictly related, the aim of this paper is to estimate how much variability in income and health is determined by external circumstances. We use data from the Survey of Health, Ageing and Retirement (SHARE) and the English Longitudinal Survey on Ageing (ELSA), two comparable multidisciplinary surveys that provide micro-level data on health and financial resources among the elderly for a large number of European countries...
April 17, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/28445388/maternal-methyl-donor-supplementation-during-gestation-counteracts-the-bisphenol-a-induced-impairment-of-intestinal-morphology-disaccharidase-activity-and-nutrient-transporters-gene-expression-in-newborn-and-weaning-pigs
#11
Hong Liu, Jun Wang, Daolin Mou, Lianqiang Che, Zhengfeng Fang, Bin Feng, Yan Lin, Shengyu Xu, Jian Li, De Wu
This study was conducted to explore whether exposure to bisphenol A (BPA) during pregnancy could change intestinal digestion and absorption function in offspring using pigs as a model, and whether methyl donor (MET) could counteract the BPA-induced impacts. Fifty Landrace × Yorkshire sows were divided into four dietary groups throughout gestation: control diet (CON); control diet supplemented with BPA (50 mg/kg); control diet supplemented with MET (3 g/kg betaine, 400 mg/kg choline, 150 μg/kg vitamin B12, and 15 mg/kg folic acid); and control diet with BPA and MET supplementation (BPA + MET)...
April 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28444953/birth-decade-affects-the-sensitization-pattern-and-asthma-risk-in-finnish-adult-population
#12
S Toppila-Salmi, A Luukkainen, R Lemmetyinen, J Karjalainen, H Huhtala, R Renkonen, D Y Wang, M J Mäkelä, J Pekkanen
BACKGROUND: We have previously shown that sensitizations to several types of allergens distinguishes subjects with and without adult-onset asthma in Finland. The aim was to analyze how age affects sensitization and asthma-risk. METHODS: We used previous population-based case-control data (N=523) from Finnish adult asthma patients with one or two matched controls. Asthma was diagnosed based on a typical history of asthmatic symptoms and lung function tests. Allergic sensitization was determined by skin prick test (SPT) to 17 aeroallergens...
April 26, 2017: Allergy
https://www.readbyqxmd.com/read/28444513/in-vitro-fertilization-when-men-women-or-both-partners-are-positive-for-hiv-a-case-control-study
#13
Pauline Vankerkem, Yannick Manigart, Annick Delvigne, Lieveke Ameye, Deborah Konopnicki, Chloë Shaw-Jackson, Serge Rozenberg, Candice Autin
PURPOSE: The aim of this study was to compare the outcomes of in vitro fertilization (IVF) for couples where one or both partners were positive for the human immunodeficiency virus (HIV) to matched control couples. METHODS: A matched case-control retrospective study was performed. Data for 104 couples where the woman was HIV-positive; for 90 couples where the man was HIV-positive; and for 33 couples where both partners were HIV-positive were prospectively analyzed in comparison to matched controls treated in our center during the same period...
April 25, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28444285/preeclampsia-screening-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#14
Jillian T Henderson, Jamie H Thompson, Brittany U Burda, Amy Cantor
Importance: Preeclampsia is a complex disease of pregnancy with sometimes serious effects on maternal and infant morbidity and mortality. It is defined by hypertension after 20 weeks' gestation and proteinuria or other evidence of multisystem involvement. Objective: To systematically review the benefits and harms of preeclampsia screening and risk assessment for the US Preventive Services Task Force. Data Sources: MEDLINE, PubMed, and Cochrane Central Register of Controlled Trials databases from 1990 through September 1, 2015...
April 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28444225/genetic-influence-on-the-sulcal-pits-on-the-origin-of-the-first-cortical-folds
#15
Yann Le Guen, Guillaume Auzias, François Leroy, Marion Noulhiane, Ghislaine Dehaene-Lambertz, Edouard Duchesnay, Jean-François Mangin, Olivier Coulon, Vincent Frouin
The influence of genes on cortical structures has been assessed through various phenotypes. The sulcal pits, which are the putative first cortical folds, have for long been assumed to be under tight genetic control, but this was never quantified. We estimated the pit depth heritability in various brain regions using the high quality and large sample size of the Human Connectome Project pedigree cohort. Analysis of additive genetic variance indicated that their heritability ranges between 0.2 and 0.5 and displays a regional genetic control with an overall symmetric pattern between hemispheres...
April 21, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28444191/risks-of-miscarriage-or-preterm-delivery-in-trichorionic-and-dichorionic-triplet-pregnancies-with-embryo-reduction-versus-expectant-management-a-systematic-review-and-meta-analysis
#16
C Anthoulakis, T Dagklis, A Mamopoulos, A Athanasiadis
STUDY QUESTION: Is pregnancy outcome in triplet pregnancies improved with embryo reduction (ER) to twins compared to expectant management? SUMMARY ANSWER: In trichorionic triplet pregnancies, ER to twins reduces the risk of preterm birth (<34 weeks) without significantly increasing the risk of miscarriage (<24 weeks), whereas in dichorionic triplet pregnancies, the results are inconclusive. WHAT IS KNOWN ALREADY: Triplet pregnancies are associated with a high risk of miscarriage and preterm birth...
April 21, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28444119/spatial-variability-in-adhd-related-behaviors-among-children-born-to-mothers-residing-near-the-new-bedford-harbor-superfund-site
#17
Verónica M Vieira, M Patricia Fabian, Thomas F Webster, Jonathan I Levy, Susan A Korrick
Attention-deficit/hyperactivity disorder (ADHD) has an uncertain etiology, with potential contributions from different risk factors such as prenatal environmental exposure to organochlorines and metals, social risk factors, and genetics. The degree to which geographic variability in ADHD is independent of, or explained by, risk factors may provide etiological insight. We investigated determinants of geographic variation in ADHD-related behaviors among children living near the polychlorinated biphenyl-contaminated New Bedford Harbor (NBH) Superfund site in Massachusetts...
April 24, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28444001/birth-weight-and-risk-of-childhood-solid-tumors-in-brazil-a-record-linkage-between-population-based-data-sets
#18
Neimar de Paula Silva, Rejane de Souza Reis, Rafael Garcia Cunha, Julio Fernando Oliveira, Fernanda Cristina da Silva de Lima, Maria Socorro Pombo-de-Oliveira, Marceli Oliveira Santos, Beatriz de Camargo
Objective: To analyze the relationship between the development of childhood solid tumors and 1) birth weight and 2) fetal growth, using two Brazilian population-based data sets. Methods: A case-cohort study was performed using two population-based data sets, and linkage between the Live Birth Information System (Sistema de Informação sobre Nascidos Vivos, SINASC) and 14 population-based cancer registries (PBCRs) was established. Four controls per case were chosen randomly from the SINASC data set...
April 20, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28443698/impact-of-maternal-nutritional-supplementation-in-conjunction-with-a-breastfeeding-support-program-on-breastfeeding-performance-birth-and-growth-outcomes-in-a-vietnamese-population
#19
Dieu T T Huynh, Nga T Tran, Lam T Nguyen, Yatin Berde, Yen Ling Low
PURPOSE: This study aimed to evaluate the effects of maternal nutritional supplementation (MNS) in conjunction with a breastfeeding support program on birth outcomes and breastfeeding performance. METHODS: A total of 228 singleton Vietnamese mothers aged 20 to 35 years at 26 to 29 weeks of gestation with pre-pregnancy body mass index (BMI) <25.0 kg/m(2) were randomized to the intervention (n = 114), receiving MNS (252 kcal/day) daily up to 12 weeks postpartum and 4 breastfeeding education and support sessions or to the control (n = 114), receiving standards of care...
April 26, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28443064/loss-of-vagal-sensitivity-to-cholecystokinin-in-rats-born-with-intrauterine-growth-retardation-and-consequence-on-food-intake
#20
Marième Ndjim, Camille Poinsignon, Patricia Parnet, Gwenola Le Dréan
Perinatal malnutrition is associated with low birth weight and an increased risk of developing metabolic syndrome in adulthood. Modification of food intake (FI) regulation was observed in adult rats born with intrauterine growth retardation induced by maternal dietary protein restriction during gestation and maintained restricted until weaning. Gastrointestinal peptides and particularly cholecystokinin (CCK) play a major role in short-term regulation of FI by relaying digestive signals to the hindbrain via the vagal afferent nerve (VAN)...
2017: Frontiers in Endocrinology
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