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https://www.readbyqxmd.com/read/28099644/use-of-biomarkers-in-pediatric-sepsis-literature-review
#1
Vanessa Soares Lanziotti, Pedro Póvoa, Márcio Soares, José Roberto Lapa E Silva, Arnaldo Prata Barbosa, Jorge Ibrain Figueira Salluh
Despite advances in recent years, sepsis is still a leading cause of hospitalization and mortality in infants and children. The presence of biomarkers during the response to an infectious insult makes it possible to use such biomarkers in screening, diagnosis, prognosis (risk stratification), monitoring of therapeutic response, and rational use of antibiotics (for example, the determination of adequate treatment length). Studies of biomarkers in sepsis in children are still relatively scarce. This review addresses the use of biomarkers in sepsis in pediatric patients with emphasis on C-reactive protein, procalcitonin, interleukins 6, 8, and 18, human neutrophil gelatinase, and proadrenomedullin...
October 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/28069685/associations-of-body-mass-index-with-laboratory-and-biomarkers-in-patients-with-acute-heart-failure
#2
Koen W Streng, Jozine M Ter Maaten, John G Cleland, Christopher M O'Connor, Beth A Davison, Marco Metra, Michael M Givertz, John R Teerlink, Piotr Ponikowski, Daniel M Bloomfield, Howard C Dittrich, Hans L Hillege, Dirk J van Veldhuisen, Adriaan A Voors, Peter van der Meer
BACKGROUND: Plasma concentrations of natriuretic peptides decline with obesity in patients with heart failure. Whether this is true for other biomarkers is unknown. We investigated a wide range of biomarker profiles in acute heart failure across the body mass index (BMI) spectrum. METHODS AND RESULTS: A total of 48 biomarkers, assessing multiple pathophysiological pathways, were measured in 2033 patients included in PROTECT (Placebo-Controlled Randomized Study of the Selective A1 Adenosine Receptor Antagonist Rolofylline for Patients Hospitalized With Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function), a trial comparing the effects of rolofylline to placebo in patients with acute heart failure...
January 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28067676/severe-community-acquired-pneumonia-optimal-management
#3
Davide Leoni, Jordi Rello
PURPOSE OF REVIEW: Community-acquired pneumonia (CAP) is the leading cause of mortality among infectious diseases. Several efforts have been implemented to achieve better outcomes, but an important proportion of patients continue dying. This review focuses on the newest research on prognostic factors and diagnostics, opening new perspectives in the management of CAP. RECENT FINDINGS: CAP survival improved in recent years despite an increasing incidence of severe presentations...
January 6, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28004184/midregional-proadrenomedullin-and-growth-differentiation-factor-15-are-not-influenced-by-obesity-in-heart-failure-patients
#4
Christoph Sinning, Francisco Ojeda, Philipp S Wild, Renate B Schnabel, Michael Schwarzl, Sevenai Ohdah, Karl J Lackner, Norbert Pfeiffer, Matthias Michal, Maria Blettner, Thomas Munzel, Tibor Kempf, Kai C Wollert, Kari Kuulasmaa, Stefan Blankenberg, Veikko Salomaa, Dirk Westermann, Tanja Zeller
BACKGROUND: Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population. METHODS: Midregional proadrenomedullin (MR-proADM), growth differentiation factor-15 (GDF-15), midregional pro-atrial natriuretic peptide (MR-proANP), and NT-proBNP were measured in 5000 individuals of the population-based Gutenberg Health Study (GHS), including 1204 obese individuals (BMI ≥ 30 kg/m(2)) and 107 individuals with HF...
December 21, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27998909/association-of-circulating-biomarkers-adrenomedullin-tnfr1-and-nt-probnp-with-renal-function-decline-in-patients-with-type-2-diabetes-a-french-prospective-cohort
#5
Pierre-Jean Saulnier, Elise Gand, Gilberto Velho, Kamel Mohammedi, Philippe Zaoui, Mathilde Fraty, Jean Michel Halimi, Ronan Roussel, Stéphanie Ragot, Samy Hadjadj
OBJECTIVE: We explored the prognostic value of three circulating candidate biomarkers-midregional-proadrenomedullin (MR-proADM), soluble tumor necrosis factor receptor 1 (sTNFR1), and N-terminal prohormone brain natriuretic peptide (NT-proBNP)-for change in renal function in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: Outcomes were defined as renal function loss (RFL), ≥40% decline of estimated glomerular filtration rate (eGFR) from baseline, and rapid renal function decline (RRFD), absolute annual eGFR slope <-5 mL/min/year...
December 20, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27956398/neurohormonal-activation-after-atrial-fibrillation-initiation-in-patients-eligible-for-catheter-ablation-a-randomized-controlled-study
#6
Emmanouil Charitakis, Håkan Walfridsson, Eva Nylander, Urban Alehagen
BACKGROUND: Biomarker activation in atrial fibrillation (AF) has been widely studied, but the immediate effect of AF initiation remains unclear. We studied the effect of AF initiation on 2 cardiac biomarkers: the N-terminal fragment of the proB-type natriuretic peptide (NT-proBNP), the midregional fragment of the N-terminal of pro-atrial natriuretic peptide (MR-proANP), and 2 extracardiac biomarkers-the copeptin and the midregional portion of proadrenomedullin (MR-proADM). METHODS AND RESULTS: This was a randomized controlled study, including 45 patients with AF who had been referred for radiofrequency ablation to the University Hospital, Linköping, Sweden, between February 2012 and April 2014...
December 12, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27880050/stable-state-proadrenomedullin-level-in-copd-patients-a-validation-study
#7
Maaike Zuur-Telgen, Paul VanderValk, Job van der Palen, Huib A M Kerstjens, Marjolein Brusse-Keizer
In patients with stable COPD, proadrenomedullin (MR-proADM) has been shown to be a good predictor for mortality. This study aims to provide an external validation of earlier observed cut-off values used by Zuur-Telgen et al. and Stolz.et al. in COPD patients in stable state and at hospitalization for an acute exacerbation of COPD (AECOPD). From the COMIC cohort study we included 545 COPD patients with a blood sample obtained in stable state (n = 490) and/or at hospitalization for an AECOPD (n = 101). Time to death was compared between patients with MR-proADM cut-off scores 0...
November 23, 2016: COPD
https://www.readbyqxmd.com/read/27846213/sensitivity-and-specificity-of-soluble-triggering-receptor-expressed-on-myeloid-cells-1-midregional-proatrial-natriuretic-peptide-and-midregional-proadrenomedullin-for-distinguishing-etiology-and-to-assess-severity-in-community-acquired-pneumonia
#8
Susanna Esposito, Maria Di Gangi, Fabio Cardinale, Eugenio Baraldi, Ilaria Corsini, Liviana Da Dalt, Pier Angelo Tovo, Antonio Correra, Alberto Villani, Oliviero Sacco, Laura Tenero, Piera Dones, Monia Gambino, Alberto Zampiero, Nicola Principi
STUDY DESIGN: This study aimed to evaluate the diagnostic accuracy of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), midregional proatrial natriuretic peptide (MR-proANP) and midregional proadrenomedullin (MR-proADM) to distinguish bacterial from viral community-acquired pneumonia (CAP) and to identify severe cases in children hospitalized for radiologically confirmed CAP. Index test results were compared with those derived from routine diagnostic tests, i.e., white blood cell (WBC) counts, neutrophil percentages, and serum C-reactive protein (CRP) and procalcitonin (PCT) levels...
2016: PloS One
https://www.readbyqxmd.com/read/27797370/the-clinical-value-of-biomarkers-in-respiratory-complications-in-hematopoietic-sct
#9
C M Lucena, M Rovira, A Gabarrús, X Filella, C Martínez, R Domingo, A Torres, C Agustí
To determine the role of biomarkers in the clinical management of respiratory complications (RC) in hematopoietic stem cell transplantation (HSCT) recipients, we have prospectively evaluated a cohort of 175 patients followed-up for 1 year after HSCT. To avoid misinterpretation, we have excluded both unidentified respiratory infections (RI) and mixed RI. A total of 64 RC were included. Plasma levels of C-reactive protein (CRP), procalcitonin (PCT) and proadrenomedullin (proADM) were measured at diagnosis and on day 3 and 7...
October 31, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27788594/the-prognostic-value-of-mr-proadrenomedullin-in-patients-with-acute-coronary-syndrome-complicated-by-cardiogenic-shock
#10
Karolina Supeł, Michał Kacprzak, Marzenna Zielińska
CONTEXT: Cardiogenic shock (CS) still remains one of the main causes of death in AMI. OBJECTIVE: The aim of this study was to evaluate the prognostic value of MR-proadrenomedullin in AMI complicated by CS. METHODS: 47 consecutive patients were included in our prospective observational study. All patients underwent coronarography and successful PCI. Plasma levels of MR-proADM were measured by a immunofluorescence method. The primary endpoint of the study, defined as cardiovascular death, occurred in 17 patients (36%)...
October 28, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27742103/obesity-paradox-in-patients-with-community-acquired-pneumonia-is-inflammation-the-missing-link
#11
Nina Braun, Claus Hoess, Alexander Kutz, Mirjam Christ-Crain, Robert Thomann, Christoph Henzen, Werner Zimmerli, Beat Mueller, Philipp Schuetz
OBJECTIVE: Positive associations between body mass index (BMI) and clinical outcomes have been found and are called "the obesity survival paradox." However, whether obesity has protective effects or if this paradox is because of confounding remains unclear. Herein, we analyzed the effects of weight on long-term mortality in a large cohort of patients with community-acquired pneumonia (CAP) and investigated whether the differential effects of obesity on inflammation pathways accounted for mortality differences...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27633393/short-term-influence-of-radiofrequency-ablation-on-nt-probnp-mr-proanp-copeptin-and-mr-proadm-in-patients-with-atrial-fibrillation-data-from-the-observational-smurf-study
#12
Emmanouil Charitakis, Håkan Walfridsson, Urban Alehagen
BACKGROUND: There is limited knowledge on the short-term influence of radiofrequency ablation (RFA) of atrial fibrillation (AF) on 2 cardiac biomarkers; the N-terminal pro-B-type natriuretic peptide (NT-proBNP) and the midregional fragment of the N-terminal of pro-ANP (MR-proANP) and 2 extracardiac biomarkers; the c-terminal provasopressin (copeptin) and the midregional portion of proadrenomedullin (MR-proADM). There are also limited data concerning cardiac production of the latter two...
September 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27609121/evaluation-of-proadrenomedullin-as-a-diagnostic-or-prognostic-biomarker-of-acute-appendicitis-in-children
#13
Concepción Míguez, Cristina Tomatis Souverbielle, Ana Haro, Gloria Guerrero, Laura Pérez-Egido, Mercedes García-Gamiz, Rafael Marañon
INTRODUCTION: A delay in the diagnosis of acute appendicitis (AA), with the added complication of symptoms that mimic other self-limited causes of abdominal pain, can lead to an increase in ruptured appendices and morbimortality. None of the serum biomarkers evaluated to date have shown a predictive value for early diagnosis. OBJECTIVE: The objective of this study was to evaluate the usefulness of proadrenomedullin (MR-proADM) in the diagnosis of AA in children presenting with acute abdominal pain...
December 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27568502/cardiovascular-mortality-in-chest-pain-patients-comparison-of-natriuretic-peptides-with-novel-biomarkers-of-cardiovascular-stress
#14
Christoph Sinning, Francisco Ojeda, Tanja Zeller, Elvin Zengin, Hans-J Rupprecht, Karl-J Lackner, Christoph Bickel, Stefan Blankenberg, Renate B Schnabel, Dirk Westermann
BACKGROUND: Natriuretic peptides are the standard biomarker for risk stratification in cardiovascular disease. Novel biomarkers of cardiovascular stress might allow refinement in risk stratification for patients with acute coronary syndrome (ACS). We tested the performance of these novel biomarkers for cardiovascular risk stratification in patients who presented with ACS. METHODS: In the AtheroGene study, 873 patients presented with ACS in the emergency department...
May 20, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27345325/adrenomedullin-regulates-intestinal-physiology-and-pathophysiology
#15
REVIEW
S Martínez-Herrero, A Martínez
Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are 2 biologically active peptides produced by the same gene, ADM, with ubiquitous distribution and many physiological functions. Adrenomedullin is composed of 52 amino acids, has an internal molecular ring composed by 6 amino acids and a disulfide bond, and shares structural similarities with calcitonin gene-related peptide, amylin, and intermedin. The AM receptor consists of a 7-transmembrane domain protein called calcitonin receptor-like receptor in combination with a single transmembrane domain protein known as receptor activity-modifying protein...
July 2016: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27307771/cardiopulmonary-laboratory-biomarkers-in-the-evaluation-of-acute-dyspnea
#16
REVIEW
Natalie R Stokes, Brett W Dietz, Jackson J Liang
Dyspnea is a common chief complaint in the emergency department, with over 4 million visits annually in the US. Establishing the correct diagnosis can be challenging, because the subjective sensation of dyspnea can result from a wide array of underlying pathology, including pulmonary, cardiac, neurologic, psychiatric, toxic, and metabolic disorders. Further, the presence of dyspnea is linked with increased mortality in a variety of conditions, and misdiagnosis of the cause of dyspnea leads to poor patient-level outcomes...
2016: Open Access Emergency Medicine: OAEM
https://www.readbyqxmd.com/read/27290423/initial-levels-of-mr-proadrenomedullin-a-predictor-of-severity-in-patients-with-influenza-a-virus-pneumonia
#17
F Valenzuela Sanchez, B Valenzuela Mendez, J F Rodríguez Gutierrez, R Bohollo de Austria, J Rubio Quiñones, L Puget Martínez, I Valiente Alemán, A Estella García
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27289930/acute-exacerbations-of-copd-aecopd-in-the-emergency-room-er-prognostic-value-of-proadrenomedulline-proadm
#18
M Dres, P Hausfater, J-M Treluyer, F Foissac, A-L Philippon, L-M Joly, M Sebbane, P Plaisance, N Roche
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27207959/multimarker-risk-stratification-in-patients-with-acute-myocardial-infarction
#19
Michelle L O'Donoghue, David A Morrow, Christopher P Cannon, Petr Jarolim, Nihar R Desai, Matthew W Sherwood, Sabina A Murphy, Robert E Gerszten, Marc S Sabatine
BACKGROUND: Several biomarkers have individually been shown to be useful for risk stratification in patients with acute myocardial infarction (MI). The optimal multimarker strategy remains undefined. METHODS AND RESULTS: Biomarkers representing different pathobiological axes were studied, including myocardial stress/structural changes (NT-pro B-type natriuretic peptide [NT-proBNP], midregional proatrial natriuretic peptide [MR-proANP], suppression of tumorigenicity 2 [ST2], galectin-3, midregional proadrenomedullin [MR-proADM], and copeptin), myonecrosis (troponin T), and inflammation (myeloperoxidase [MPO], high sensitivity C-reactive protein [hsCRP], pregnancy-associated plasma protein A [PAPP-A], and growth-differentiation factor-15 [GDF-15]), in up to 1258 patients from Clopidogrel as Adjunctive Reperfusion Therapy-Thrombolysis in Myocardial Infarction 28 (CLARITY-TIMI 28), a randomized trial of clopidogrel in ST-elevation MI (STEMI)...
May 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27160747/mid-regional-proadrenomedullin-an-early-marker-of-response-in-critically-ill-patients-with-severe-community-acquired-pneumonia
#20
J M Pereira, A Azevedo, C Basílio, C Sousa-Dias, P Mergulhão, J A Paiva
BACKGROUND: Mid-regional proadrenomedullin (MR-proADM) is a novel biomarker with potential prognostic utility in patients with community-acquired pneumonia (CAP). PURPOSE: To evaluate the value of MR-proADM levels at ICU admission for further severity stratification and outcome prediction, and its kinetics as an early predictor of response in severe CAP (SCAP). MATERIALS AND METHODS: Prospective, single-center, cohort study of 19 SCAP patients admitted to the ICU within 12h after the first antibiotic dose...
November 2016: Revista Portuguesa de Pneumologia
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