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Nina Braun, Claus Hoess, Alexander Kutz, Mirjam Christ-Crain, Robert Thomann, Christoph Henzen, Werner Zimmerli, Beat Mueller, Philipp Schuetz
OBJECTIVE: Positive associations between body mass index (BMI) and clinical outcomes have been found and are called "the obesity survival paradox." However, whether obesity has protective effects or if this paradox is because of confounding remains unclear. Herein, we analyzed the effects of weight on long-term mortality in a large cohort of patients with community-acquired pneumonia (CAP) and investigated whether the differential effects of obesity on inflammation pathways accounted for mortality differences...
August 9, 2016: Nutrition
Emmanouil Charitakis, Håkan Walfridsson, Urban Alehagen
BACKGROUND: There is limited knowledge on the short-term influence of radiofrequency ablation (RFA) of atrial fibrillation (AF) on 2 cardiac biomarkers; the N-terminal pro-B-type natriuretic peptide (NT-proBNP) and the midregional fragment of the N-terminal of pro-ANP (MR-proANP) and 2 extracardiac biomarkers; the c-terminal provasopressin (copeptin) and the midregional portion of proadrenomedullin (MR-proADM). There are also limited data concerning cardiac production of the latter two...
September 2016: Journal of the American Heart Association
Concepción Míguez, Cristina Tomatis Souverbielle, Ana Haro, Gloria Guerrero, Laura Pérez-Egido, Mercedes García-Gamiz, Rafael Marañon
INTRODUCTION: A delay in the diagnosis of acute appendicitis (AA), with the added complication of symptoms that mimic other self-limited causes of abdominal pain, can lead to an increase in ruptured appendices and morbimortality. None of the serum biomarkers evaluated to date have shown a predictive value for early diagnosis. OBJECTIVE: The objective of this study was to evaluate the usefulness of proadrenomedullin (MR-proADM) in the diagnosis of AA in children presenting with acute abdominal pain...
August 16, 2016: American Journal of Emergency Medicine
Christoph Sinning, Francisco Ojeda, Tanja Zeller, Elvin Zengin, Hans-J Rupprecht, Karl-J Lackner, Christoph Bickel, Stefan Blankenberg, Renate B Schnabel, Dirk Westermann
BACKGROUND: Natriuretic peptides are the standard biomarker for risk stratification in cardiovascular disease. Novel biomarkers of cardiovascular stress might allow refinement in risk stratification for patients with acute coronary syndrome (ACS). We tested the performance of these novel biomarkers for cardiovascular risk stratification in patients who presented with ACS. METHODS: In the AtheroGene study, 873 patients presented with ACS in the emergency department...
May 20, 2016: Canadian Journal of Cardiology
S Martínez-Herrero, A Martínez
Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are 2 biologically active peptides produced by the same gene, ADM, with ubiquitous distribution and many physiological functions. Adrenomedullin is composed of 52 amino acids, has an internal molecular ring composed by 6 amino acids and a disulfide bond, and shares structural similarities with calcitonin gene-related peptide, amylin, and intermedin. The AM receptor consists of a 7-transmembrane domain protein called calcitonin receptor-like receptor in combination with a single transmembrane domain protein known as receptor activity-modifying protein...
July 2016: Domestic Animal Endocrinology
Natalie R Stokes, Brett W Dietz, Jackson J Liang
Dyspnea is a common chief complaint in the emergency department, with over 4 million visits annually in the US. Establishing the correct diagnosis can be challenging, because the subjective sensation of dyspnea can result from a wide array of underlying pathology, including pulmonary, cardiac, neurologic, psychiatric, toxic, and metabolic disorders. Further, the presence of dyspnea is linked with increased mortality in a variety of conditions, and misdiagnosis of the cause of dyspnea leads to poor patient-level outcomes...
2016: Open Access Emergency Medicine: OAEM
F Valenzuela Sanchez, B Valenzuela Mendez, J F Rodríguez Gutierrez, R Bohollo de Austria, J Rubio Quiñones, L Puget Martínez, I Valiente Alemán, A Estella García
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
M Dres, P Hausfater, J-M Treluyer, F Foissac, A-L Philippon, L-M Joly, M Sebbane, P Plaisance, N Roche
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
Michelle L O'Donoghue, David A Morrow, Christopher P Cannon, Petr Jarolim, Nihar R Desai, Matthew W Sherwood, Sabina A Murphy, Robert E Gerszten, Marc S Sabatine
BACKGROUND: Several biomarkers have individually been shown to be useful for risk stratification in patients with acute myocardial infarction (MI). The optimal multimarker strategy remains undefined. METHODS AND RESULTS: Biomarkers representing different pathobiological axes were studied, including myocardial stress/structural changes (NT-pro B-type natriuretic peptide [NT-proBNP], midregional proatrial natriuretic peptide [MR-proANP], suppression of tumorigenicity 2 [ST2], galectin-3, midregional proadrenomedullin [MR-proADM], and copeptin), myonecrosis (troponin T), and inflammation (myeloperoxidase [MPO], high sensitivity C-reactive protein [hsCRP], pregnancy-associated plasma protein A [PAPP-A], and growth-differentiation factor-15 [GDF-15]), in up to 1258 patients from Clopidogrel as Adjunctive Reperfusion Therapy-Thrombolysis in Myocardial Infarction 28 (CLARITY-TIMI 28), a randomized trial of clopidogrel in ST-elevation MI (STEMI)...
May 2016: Journal of the American Heart Association
J M Pereira, A Azevedo, C Basílio, C Sousa-Dias, P Mergulhão, J A Paiva
BACKGROUND: Mid-regional proadrenomedullin (MR-proADM) is a novel biomarker with potential prognostic utility in patients with community-acquired pneumonia (CAP). PURPOSE: To evaluate the value of MR-proADM levels at ICU admission for further severity stratification and outcome prediction, and its kinetics as an early predictor of response in severe CAP (SCAP). MATERIALS AND METHODS: Prospective, single-center, cohort study of 19 SCAP patients admitted to the ICU within 12h after the first antibiotic dose...
May 5, 2016: Revista Portuguesa de Pneumologia
Johannes Tobias Neumann, Marius Schwerg, Oliver Dörr, Kai Mortensen, Klaas Franzen, Tanja Zeller, Francisco Ojeda, Stefan Blankenberg, Christian Hamm, Holger Nef, Verena Stangl, Martin Möckel, Karsten Sydow
BACKGROUND: Renal denervation has been proposed as a therapeutic option in patients with resistant hypertension. Circulating blood borne biomarkers might be helpful to identify individuals responding to RDN therapy. MR-proADM is a strong prognostic marker in patients with cardiovascular disease. The aim of this multicenter study was to evaluate the effect of RDN on MR-proADM concentrations. METHODS AND RESULTS: We measured MR-proADM, BNP, and MR-proANP in 110 patients before and after RDN in a multicenter setting...
May 6, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Jian Ma, Yinglu Feng, Zaiquan Li, Chaoshu Tang
OBJECTIVES: The study aimed to investigate the effects of adrenomedullin (ADM) and proadrenomedullin N- terminal 20 peptide (PAMP) on angiotensin (AngII)-stimulated proliferation in vascular smooth muscle cells (VSMCs). MATERIALS AND METHODS: Thoracic aorta was obtained from Wistar rats and VSMCs were isolated from aorta tissues and then cultured. In vitro cultured VSMCs were stimulated with Ang II (10(-8) mol/l) followed by various doses of PAMP or ADM (10(-9), 10(-8), or 10(-7) mol/l)...
January 2016: Iranian Journal of Basic Medical Sciences
Susan Felder, Nina Braun, Zeno Stanga, Prasad Kulkarni, Lukas Faessler, Alexander Kutz, Deborah Steiner, Svenja Laukemann, Sebastian Haubitz, Andreas Huber, Beat Mueller, Philipp Schuetz
BACKGROUND AND AIMS: Malnutrition is associated with poor clinical outcomes. Whether there is a causal relationship or it merely mirrors a severe patient condition remains unclear. We examined the association of malnutrition with biomarkers characteristic of different pathophysiological states to better understand the underlying etiological mechanisms. METHODS: We prospectively followed consecutive adult medical inpatients. Multivariable regression models were used to investigate the associations between malnutrition - as assessed using the Nutritional Risk Screening (NRS 2002) - and biomarkers linked to inflammation, stress, renal dysfunction, nutritional status and hematologic function...
2016: Annals of Nutrition & Metabolism
Silvia Angeletti, Giordano Dicuonzo, Marta Fioravanti, Marina De Cesaris, Marta Fogolari, Alessandra Lo Presti, Massimo Ciccozzi, Lucia De Florio
BACKGROUND: Elevated cytokines levels correlate with sepsis severity and mortality but their role in the diagnosis is controversial, whereas Procalcitonin (PCT) has been largely used. Recently, the mid-regional proadrenomedullin (MR-proADM) has been combined with PCT for diagnosis optimization. In this study the combined measurement of PCT, MR-proADM, and cytokines in patients with sepsis was evaluated. METHODS: One hundred and four septic patients and 101 controls were enrolled...
2015: Disease Markers
Adam Csordas, Fabian Nietlispach, Philipp Schuetz, Andreas Huber, Beat Müller, Francesco Maisano, Maurizio Taramasso, Igal Moarof, Slayman Obeid, Barbara E Stähli, Martin Cahenzly, Ronald K Binder, Christoph Liebetrau, Helge Möllmann, Won-Keun Kim, Christian Hamm, Thomas F Lüscher
BACKGROUND: Conventional surgical risk scores lack accuracy in risk stratification of patients undergoing transcatheter aortic valve replacement (TAVR). Elevated levels of midregional proadrenomedullin (MR-proADM) levels are associated with adverse outcome not only in patients with manifest chronic disease states, but also in the general population. OBJECTIVES: We investigated the predictive value of MR-proADM for mortality in an unselected contemporary TAVR population...
2015: PloS One
Takashi Tsuchiya, Tsukasa Osaki, Naoto Minamino, Kazuki Sasaki
Limited proteolysis is a pivotal mechanism regulating protein functions. Identifying physiologically or pathophysiologically relevant cleavage sites helps to develop molecular tools that can be used for diagnostics or therapeutics. During proteolysis of secretory and membrane proteins, part of the cleaved protein is liberated and destined to undergo degradation but should retain original cleavage sites created by proteolytic enzymes. We profiled endogenous peptides accumulated for 4 h in media conditioned by primary cultured rat cardiac fibroblasts...
November 6, 2015: Journal of Proteome Research
J Riera, A Senna, M Cubero, A Roman, J Rello
Primary graft dysfunction (PGD) after lung transplantation (LT) is a heterogeneous syndrome that comprises clinical presentations with diverse grades of severity. Proadrenomedullin (proADM) levels may be associated with PGD and may enhance its relationship with outcomes. We prospectively included 100 LT recipients. Plasma levels of proADM were measured at 24, 48 and 72 h after admission to the intensive care unit (ICU). We assessed their relationship with PGD grade and ICU mortality. Fifty patients (50%) presented grade 3 PGD at ICU admission...
February 2016: American Journal of Transplantation
Gabriel Alcoba, Sergio Manzano, Laurence Lacroix, Annick Galetto-Lacour, Alain Gervaix
BACKGROUND: Community-acquired-pneumonia is the leading cause of child mortality worldwide. Very few studies have explored the predictive value of Proadrenomedullin and Copeptin in pediatric severe pneumonia and bacteremia. METHODS: Proadrenomedullin and Copeptin were assessed as predictors for complicated community-acquired pneumonia (bacteremia, empyema) in 88 children aged 0 to 16 years presenting to the pediatric emergency department, using B.R.A.H.M.S. Kryptor Compact pro-ADM and Copeptin with the TRACE technology (time-resolved amplified cryptase emission)...
2015: BMC Infectious Diseases
S Bello, S Fandos, A B Lasierra, E Mincholé, C Panadero, A L Simon, O Gavin, F De Pablo, R Menendez, A Torres
Proadrenomedullin (proADM), a cardiovascular biomarker, has shown high prognostic power for community-acquired pneumonia (CAP) outcomes. Red-blood-cell distribution width (RDW), linked to cardiovascular disorders, has been associated with short-term and medium-term mortality after CAP. Our objective was to assess the accuracy of both biomarkers for CAP long-term mortality (>90 days). Adults hospitalized with CAP underwent blood proADM, RDW, C-reactive protein (CRP) and procalcitonin (PCT) measurements at admission, and were evaluated after 30, 90, and 180 days, and 1, 2, and 3 years, until either death or 5 years of follow-up...
September 2015: Respiratory Medicine
Haihui Wu, Meiqi Zeng, Eric Y P Cho, Wenqi Jiang, Ou Sha
Mas-related genes (Mrgs) belong to a large family of G protein-coupled receptor genes found in rodents. Human MRGX proteins are G protein-coupled 7-transmembrane proteins sharing 41-52% amino acid identity with each other, but have no orthologs in rodents. MrgX2 is a member of the MrgX family. MRGX2 is expressed in the small neurons of sensory ganglia and mast cells. It can interact with a series of factors and genes such as the peptides substance P, vasoactive intestinal peptide, cortistatin (CST), proadrenomedullin N-terminal peptide (PAMP), LL-37, PMX-53 and β-defensins...
July 2015: Progress in Histochemistry and Cytochemistry
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