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https://www.readbyqxmd.com/read/28295458/improvement-in-erectile-function-in-a-rat-model-of-high-cholesterol-diet-induced-atherosclerosis-by-atorvastatin-in-a-manner-that-is-independent-of-its-lipid-lowering-property
#1
Z Zhang, L Tang, W Yu, Y Chen, Y-T Dai
The purpose of the present study is to explore the effects of a lipid-lowering drug atorvastatin, a three-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, in the treatment of erectile dysfunction (ED) in a rat model of atherosclerosis (AS) and the possible mechanisms underneath. A high-cholesterol diet was administrated to Sprague-Dawley rats in an attempt to induce an ASED model, which was later confirmed by abdominal aorta histopathology and erectile function evaluation. ASED rats were further assigned to non-treatment group, atorvastatin low-dose treatment group (5 mg kg(-1)  day(-1) ), high-dose group (10 mg kg(-1)  day(-1) ) and sildenafil (1...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28280316/the-impact-of-hypomagnesemia-on-erectile-dysfunction-in-elderly-non-diabetic-stage-3-and-4-chronic-kidney-disease-patients-a-prospective-cross-sectional-study
#2
Omer Toprak, Yasin Sarı, Akif Koç, Erhan Sarı, Ali Kırık
BACKGROUND: Erectile dysfunction (ED) is common in older men with chronic kidney disease. Magnesium is essential for metabolism of nitric oxide which helps in penile erection. There is little information available about the influence of serum magnesium on ED. The aim of the study was to assess the influence of hypomagnesemia on ED in elderly chronic kidney disease patients. SUBJECTS AND METHODS: A total of 372 patients aged 65-85 years, with an estimated glomerular filtration rate of 60-15 mL/min/1...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28235412/the-herbal-formula-kh-204-is-protective-against-erectile-dysfunction-by-minimizing-oxidative-stress-and-improving-lipid-profiles-in-a-rat-model-of-erectile-dysfunction-induced-by-hypercholesterolaemia
#3
Hoon Jang, Woong Jin Bae, Su Jin Kim, Hyuk Jin Cho, Seung Mo Yuk, Dong Seok Han, Chang Shik Youn, Eun Bi Kwon, Sung Yeoun Hwang, Sae Woong Kim
BACKGROUND: Hypercholesterolaemia (HC) is a major risk factor for ischemic heart disease and is also known to be a risk factor for erectile dysfunction (ED). ED caused by HC is thought to be related to HC-induced oxidative stress damage in the vascular endothelium and erectile tissue. KH-204 is an herbal formula with a strong antioxidant effect. We evaluated the effects of KH-204 on erectile function in a rat model of HC-induced ED. METHODS: Male Sprague-Dawley rats (6 weeks old) were divided into normal control, high-fat and cholesterol diet (HFC), and HFC with KH-204 treatment (HFC + KH) groups (n = 12 each)...
February 24, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28179637/the-relationship-between-acquired-premature-ejaculation-and-metabolic-syndrome-a-prospective-comparative-study
#4
D Bolat, G U Kocabas, B Gunlusoy, O Aydogdu, M E Aydin
The aim of this study was to investigate the relationship between metabolic syndrome (MetS) and acquired premature ejaculation (PE). A total of 100 patients with acquired PE and 100 control cases were enrolled in the study. After obtaining a detailed medical history, anthropometric (weight, height and waist circumference) and blood pressure measurements were performed. Ejaculation and erection functions were evaluated by Premature Ejaculation Diagnostic Tool (PEDT) and International Index of Erectile Function-5 (IIEF-5), respectively...
February 9, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28109691/erectile-dysfunction-in-male-adults-with-atopic-dermatitis-and-psoriasis
#5
Alexander Egeberg, Peter R Hansen, Gunnar H Gislason, Lone Skov, Jacob P Thyssen
INTRODUCTION: Patients with psoriasis have increased risk of cardiovascular disease, but data on atopic dermatitis (AD) are less clear-cut. However, it is well-established that erectile dysfunction (ED) can serve as a risk marker for coronary disease. AIM: To investigate the incidence, prevalence, and risk of ED in men with psoriasis and AD. METHODS: The sample included all Danish men at least 30 years old. In patients with AD and psoriasis, we determined disease severity based on use of systemic therapy...
January 18, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27919363/the-effects-of-statin-treatment-on-adrenal-and-sexual-function-and-nitric-oxide-levels-in-hypercholesterolemic-male-patients-treated-with-a-statin
#6
Osman Baspınar, Fahri Bayram, Selda Korkmaz, Murat Aksu, Derya Kocer, Oğuzhan Sıtkı Dizdar, Yasin Simsek, Peter P Toth
BACKGROUND: Erectile dysfunction complaints among men treated with a statin are not uncommon. OBJECTIVES: To evaluate the effect of lowering low-density lipoprotein cholesterol (LDL-C) to target levels using varying doses of atorvastatin therapy in hypercholesterolemic male patients on adrenocortical hormones, sexual functions, and serum nitric oxide (NO) levels. METHODS: Eleven hypercholesterolemic male patients who had LDL-C levels greater than 160 mg/dL were included in the study and 11 healthy male individuals served as controls...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27914613/association-between-cardiometabolic-index-and-erectile-dysfunction-a-new-index-for-predicting-cardiovascular-disease
#7
Murat Dursun, Huseyin Besiroglu, Alper Otunctemur, Emin Ozbek
Over the past decade, it has been suggested that erectile dysfunction (ED) is an early indicator of cardiovascular disease. In a recent study, a new index, termed as cardiometabolic index (CMI), was defined and measured as the product of triglyceride (TG)/high-density lipoprotein-cholesterol (HDL-C) ratio and waist-to-height ratio, which are good predictors of coronary artery disease and main components of metabolic syndrome (MetS). All components of the CMI are also included in MetS criteria. Thus, we decided to evaluate the correlation between CMI, including the criteria of MetS, and ED...
December 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27819758/effect-of-tadalafil-5mg-daily-treatment-on-the-ejaculatory-times-lower-urinary-tract-symptoms-and-erectile-function-in-patients-with-erectile-dysfunction
#8
Mehmet Karabakan, Ercument Keskin, Serkan Akdemir, Aliseydi Bozkurt
OBJECTIVE: To investigate the effect of a 5mg daily tadalafil treatment on the ejaculation time, erectile function and lower urinary tract symptoms (LUTS) in patients with erectile dysfunction. MATERIALS AND METHODS: A total of 60 patients diagnosed with erectile dysfunction were retrospectively evaluated using the international index of erectile function questionnaire-5 (IIEF-5), intravaginal ejaculatory latency time (IELT) and international prostate symptoms scores (IPSS)...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27619893/hyperlipidemia-impairs-erectile-function-in-rats-by-causing-cavernosal-fibrosis
#9
R Li, K Cui, T Wang, S Wang, X Li, J Qiu, G Yu, J Liu, B Wen, K Rao
Men with hyperlipidemia are more likely to have erectile dysfunction (ED) than those without hyperlipidemia, but the mechanisms are not fully understood. The aim of this study was to investigate the underlying mechanism of ED caused by hyperlipidemia. Fourteen 8-week-old Sprague-Dawley rats were randomly divided into two groups: a control group and a hyperlipidemia group (fed chow containing 4% cholesterol and 1% cholic acid). After 6 months, we assessed erectile function by performing cavernous nerve electrostimulation followed by intracavernosal pressure/mean arterial pressure measurements, as well as plasma lipid profile assessment in all rats...
September 13, 2016: Andrologia
https://www.readbyqxmd.com/read/27562011/thiol-disulphide-homeostasis-levels-in-erectile-dysfunction-patients
#10
Y Ustundag-Budak, M Sambel, M Alisik, M Aydos, O Erel, S Oner, M Demirbas, M Kilic, D Unal
This study explored the use of thiol/disulphide homeostasis as a novel oxidative stress marker in patients with erectile dysfunction (ED). Fifty-five patients aged 40-57 were divided into two groups: Group I (International Index of Erectile Function [IIEF-5] score between 22 and 25, n = 20) and Group II (IIEF-5 score < 22, n = 35). Blood samples were used to evaluate hormone levels, lipid profile and thiol/disulphide levels. A novel, fully automated method measured plasma native thiol, total thiol and disulphide levels...
August 26, 2016: Andrologia
https://www.readbyqxmd.com/read/27513408/effects-of-resveratrol-on-the-alterations-of-cavernosal-enos-and-lox-1-expression-in-the-hypercholesterolemic-condition-a-preliminary-study
#11
Ozan Bozkurt, Aykut Kefi, Ömer Demir, Nergis Murat, Sedef Gidener, Ahmet Adil Esen
BACKGROUND/AIM: The aim of this study was to determine the effects of resveratrol on the alterations of cavernosal eNOS and LOX-1 mRNA expression in the hypercholesterolemic condition. MATERIALS AND METHODS: Twenty-one New Zealand white male rabbits were separated into three groups. Rabbits were fed with a normal dietary intake for the control group and a 2% cholesterol diet for the hypercholesterolemia and resveratrol groups for 6 weeks. Resveratrol 4 mg/kg daily was administered for the resveratrol group...
2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27468624/-mechanism-of-rhoa-rho-kinase-signal-pathway-induced-erectile-dysfunction-in-hyperlipidemic-rats
#12
R Li, K Cui, T Wang, S G Wang, W M Yang, J H Liu, K Rao
OBJECTIVE: To investigate the expression of RhoA/Rho-kinase (ROCK) in penile corpus cavernosum smooth muscles in rats of hyperlipidemia-induced erectile dysfunction and its molecular mechanism. METHODS: Forty male Sprague-Dawley rats were randomly divided into control and experimental groups using a random number table. Rats in the control group (n=20) were fed with regular diet for 24 weeks and those in the experimental group (n=20) with high-fat diet for the same period of time...
July 12, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27439215/improvement-of-endothelial-function-in-a-murine-model-of-mild-cholesterol-induced-atherosclerosis-by-mineralocorticoid-antagonism
#13
Mario T Kratz, Stephan H Schirmer, Magnus Baumhäkel, Michael Böhm
BACKGROUND AND AIMS: The renin-angiotensin-aldosterone-system (RAAS) plays a role in endothelial dysfunction and atherosclerosis. During treatment with RAAS-inhibitors, elevated aldosterone may sustain "aldosterone escape". METHODS: We investigated the effects of treatment with the mineralocorticoid antagonist eplerenone (Ep) compared with ramipril (Rami) or the combination of both on oxidative stress, plaque formation and endothelial function, in atherosclerotic apolipoprotein E deficient mice (ApoE(-/-)-mice)...
August 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27436076/effects-of-8-year-treatment-of-long-acting-testosterone-undecanoate-on-metabolic-parameters-urinary-symptoms-bone-mineral-density-and-sexual-function-in-men-with-late-onset-hypogonadism
#14
Sompol Permpongkosol, Kalayanee Khupulsup, Supatra Leelaphiwat, Sarawan Pavavattananusorn, Supranee Thongpradit, Thanom Petchthong
INTRODUCTION: The long-term effects of long-acting testosterone undecanoate (TU) and androgen receptor CAG repeat lengths in Thai men with late-onset hypogonadism (LOH) have not been reported. AIM: To analyze the 8-year follow-up effects of intramuscular TU therapy on metabolic parameters, urinary symptoms, bone mineral density, and sexual function and investigate CAG repeat lengths in men with LOH. METHODS: We reviewed the medical records of 428 men with LOH who had been treated with TU and 5 patients were diagnosed with prostate cancer during TU therapy...
August 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27172660/-risk-factors-of-erectile-dysfunction-in-patients-with-cardiovascular-diseases
#15
Jun-ping Xing, Liang Ning, Hui-ming Chen, Tan Tan
OBJECTIVE: To investigate the penile erectile function of hospitalized male patients with cardiovascular diseases, the incidence of erectile dysfunction (ED) in this cohort, and the relationship of ED with cardiovascular diseases and its risk factors. METHODS: Using a self-designed questionnaire, we conducted an investigation among the hospitalized patients in the Department of Cardiovascular Diseases of the First and Second Affiliated Hospitals of Xi'an Jiaotong University...
March 2016: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/27125688/the-synergy-effect-of-daidzein-and-genistein-isolated-from-butea-superba-roxb-on-the-reproductive-system-of-male-mice
#16
Griangsak Eumkeb, Sudarat Tanphonkrang, Kittipot Sirichaiwetchakoon, Tanaporn Hengpratom, Wanatkamon Naknarong
Butea superba Roxb. (BS) has been used in Thai men as an aphrodisiac, and prevent erectile dysfunction. Nevertheless, the active ingredients, dosages, have not been cleared. Hence, this study was to investigate the effect of compounds from the BS on the reproductive parameters of male mice. The results revealed that BS was extracted to afford biochanin A and genistein, which were first reported on BS, and daidzein. The mice were treated by daidzein and genistein alone and in combination. The results showed that the sperm number and motility, cholesterol and testosterone level of all isoflavones-treated groups were significantly higher than controls (p < 0...
March 2017: Natural Product Research
https://www.readbyqxmd.com/read/27052235/-sex-and-gender-aspects-in-regard-to-clinical-practice-recommendations-for-pre-diabetes-and-diabetes
#17
REVIEW
Alexandra Kautzky-Willer, Heidemarie Abrahamian, Raimund Weitgasser, Peter Fasching, Fritz Hoppichler, Monika Lechleitner
Metabolic diseases dramatically affect life of men and women from infancy up to old age and are a major challenge for clinicians. Health professionals are confronted with different needs of women and men. This article aims at an increase of gender awareness and the implementation of current knowledge of gender medicine in daily clinical practice with regard to pre-diabetes and diabetes. Sex and gender affect screening and diagnosis of metabolic diseases as well as treatment strategies and outcome. Impaired glucose and lipid metabolism, regulation of energy balance and body fat distribution are related to steroid hormones and therefore impose their influence on cardiovascular health in both men and women...
April 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/26960674/risk-factors-for-erectile-dysfunction-in-patients-with-cardiovascular-disease
#18
Rakesh Kumar Chaudhary, Bilal Haider Shamsi, Hui-Ming Chen, Tan Tan, Kai-Fa Tang, Jun-Ping Xing
OBJECTIVE: To examine the relationship between risk factors for cardiac disease and erectile dysfunction (ED) in men from Xi'an, China. METHODS: Participants were patients with cardiovascular disease who visited the Cardiovascular Medicine Department of Xi'an Jiaotong University First Affiliated Hospital between September 2011 and March 2012. Two hundred and fifty patients were issued with questionnaires and underwent a physical examination and blood test.Risk factors for ED were identified using univariate and multivariate analyses...
June 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/26812302/sac-1004-a-pseudo-sugar-derivative-of-cholesterol-restores-erectile-function-through-reconstruction-of-nonleaky-and-functional-cavernous-angiogenesis-in-the-streptozotocin-induced-diabetic-mouse
#19
Dulguun Batbold, Kang-Moon Song, Jin-Mi Park, Soo-Hwan Park, Tack Lee, Dong-Soo Ryu, Young-Ger Suh, Young-Guen Kwon, Ji-Kan Ryu, Jun-Kyu Suh
PURPOSE: We examined whether and how Sac-1004, a vascular leakage blocker, would restore erectile function in an animal model of diabetic erectile dysfunction. MATERIALS AND METHODS: Eight-week-old C57BL/6J mice were used. Diabetes was induced by intraperitoneal injection of streptozotocin. Eight weeks after diabetes induction the animals were divided into 6 groups, including controls, diabetic mice that received repeat intracavernous injections of phosphate buffered saline (20 μl) on days -3 and 0, and diabetic mice that received repeat intracavernous injections of Sac-1004 on days -3 and 0 (1, 2, 5 and 10 μg, respectively, in 20 μl phosphate buffered saline)...
June 2016: Journal of Urology
https://www.readbyqxmd.com/read/26803454/melatonin-improves-erectile-function-in-rats-with-chronic-lower-body-ischemia
#20
Norifumi Sawada, Masanori Nomiya, Mona Zarifpour, Takahiko Mitsui, Masayuki Takeda, Karl-Erik Andersson
INTRODUCTION: Arterial occlusive disease is the leading cause of erectile dysfunction (ED). Using an established rat model we wanted to characterize the changes caused by atherosclerosis-induced chronic ischemia on penile structures and erectile function. AIM: To investigate the effect of melatonin on these parameters. METHODS: Adult male Sprague-Dawley rats were divided into control, arterial injury (AI) and AI with melatonin treatment groups...
February 2016: Journal of Sexual Medicine
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