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https://www.readbyqxmd.com/read/28125446/inpatient-gamma-hydroxybutyrate-detoxification-a-case-report-describing-day-to-day-therapeutic-management
#1
Louis von Theobald, Morgane Rousselet, Jennyfer Cholet, Hélène Debar, David Boels, Caroline Victorri-Vigneau, Marie Grall-Bronnec
BACKGROUND: Gamma-hydroxybutyrate (GHB) is a synthetic drug increasingly used by consumers of psychoactive substances. The sought after psychoactive effects of GHB have resulted in an increase in recreational use in Europe. GHB is considered to have a high dependence potential, and abrupt discontinuation after long-term use can result in a severe withdrawal syndrome. Despite a large number of publications related to GHB withdrawal and detoxification, to date, no evidence-based protocol or consensual international therapeutic guidelines are available (over and above the administration of benzodiazepines)...
January 25, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28054436/low-dose-of-caffeine-enhances-the-efficacy-of-antidepressants-in-major-depressive-disorder-and-the-underlying-neural-substrates
#2
Qing-Shan Liu, Ran Deng, Yuyan Fan, Keqin Li, Fanggang Meng, Xueli Li, Rui Liu
SCOPE: Caffeine is one of the most frequently used psychoactive substances ingested mainly via beverage or food products. Major depressive disorder is a serious and devastating psychiatric disorder. Emerging evidence indicates that caffeine enhances the antidepressant-like activity of common antidepressant drugs in rodents. However, whether joint administration of low dose of caffeine enhances the antidepressant actions in depressed patients remains unclear. METHODS AND RESULTS: A total of 95 male inpatients were assigned to three groups and were asked to take either caffeine (60, 120mg) or placebo (soymilk powder) daily for 4 weeks on the basis of their current antidepressant medications...
January 5, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28035127/medical-use-nonmedical-use-of-prescription-medication-and-risk-behaviour-among-croatian-adolescents
#3
Marina Kuzman, Marija Posavec
BACKGROUND: At the drug scene some major shifts were observed, more and more reports highlighted the abuse of prescription medication. Despite the importance of controlled medication in treatment child and adolescent disorders, this increase may be a factor which influence misuse and nonmedical use of prescribed drugs among adolescents. SUBJECT AND METHODS: Croatian data from ESPAD survey in 2003, 2007 and 2011 were used, and variables selected from the international ESPAD questionnaire...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/28029499/development-of-an-enantioseparation-method-for-novel-psychoactive-drugs-by-hplc-using-a-lux-%C3%A2-cellulose-2-column-in-polar-organic-phase-mode
#4
Magdalena Taschwer, Jörg Grascher, Martin G Schmid
Since the last decade, the hype of the recreational use of novel psychoactive drugs is still on its top in entire Europe. Every year, new derivatives enter the drug market and enlarge the broad spectrum of misused drugs. Many of these compounds contain a stereogenic centre and therefore two enantiomers exist. It is obvious that the pharmacological potency of the isomers differ as it is already known from various pharmaceutical ingredients. Therefore, the development of analytical methods for the chiral separation of new psychoactive substances is of great medical and forensic interest...
October 20, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27798074/stability-of-tetrahydrocannabinol-and-cannabidiol-in-prepared-quality-control-medible-brownies
#5
Carl E Wolf, Justin L Poklis, Alphonse Poklis
The legalization of marijuana in the USA for both medicinal and recreational use has increased in the past few years. Currently, 24 states have legalized marijuana for medicinal use. The US Drug Enforcement Administration has classified marijuana as a Schedule I substance. The US Food and Drug Administration does not regulate formulations or packages of marijuana that are currently marketed in states that have legalized marijuana. Marijuana edibles or "medibles" are typically packages of candies and baked goods consumed for medicinal as well as recreational marijuana use...
October 18, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27789102/nps-and-the-methadone-queue-spillages-of-space-and-time
#6
Liviu Alexandrescu
BACKGROUND: Between 2008 and 2013, powder-stimulants sold by 'head shops' as novel psychoactive substances (NPS) or 'legal highs' have displaced heroin among groups of injecting substance users in Bucharest, Romania. Rising HIV-infection rates and other medical or social harms have been reported to follow this trend. METHODS: The study builds on two sets of original (N=30) and existing (N=20) interview data and on observations collected mainly at the site of a methadone substitution treatment facility...
October 24, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27775683/-hospital-emergencies-associated-with-the-consumption-of-hypnotics-and-sedatives-2009-2013-castilla-y-le%C3%A3-n-spain
#7
Verónica Rubio González, Susana Redondo Martín, Gema Ruíz López Del Prado, Mª Fe Muñoz Moreno, Alexander Velázquez Miranda
OBJECTIVE: Household Survey on Alcohol and Other Drugs shows the progressive increase in the consumption of hypnotics, alone or in combination with other substances. The aim of the research was to obtain information about the consumption of hypnotics and sedatives in population of Castilla y León treated in emergency medical services of four monitored hospitals between 2009-2013, describing clinical and epidemiological characteristics of the emergencies and what drugs were consumed, to provide information for future interventions...
October 24, 2016: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/27701009/cannabis-and-its-effects-on-driving-skills
#8
REVIEW
Percy Bondallaz, Bernard Favrat, Haïthem Chtioui, Eleonora Fornari, Philippe Maeder, Christian Giroud
Traffic policies show growing concerns about driving under the influence of cannabis, since cannabinoids are one of the most frequently encountered psychoactive substances in the blood of drivers who are drug-impaired and/or involved in accidents, and in the context of a legalization of medical marijuana and of recreational use. The neurobiological mechanisms underlying the effects of cannabis on safe driving remain poorly understood. In order to better understand its acute and long-term effects on psychomotor functions involved in the short term ability and long-term fitness to drive, experimental research has been conducted based on laboratory, simulator or on-road studies, as well as on structural and functional brain imaging...
November 2016: Forensic Science International
https://www.readbyqxmd.com/read/27663045/-predictors-of-medication-non-adherence-among-a-moroccan-sample-of-patients-with-schizophrenia-a-cross-sectional-study
#9
A El Ammouri, H Kisra
BACKGROUND: Schizophrenia is a chronic, relapsing, mental disorder, and lack of adherence is a common and severe problem in such patients leadingto global and heavy consequences for patients (relapses, hospitalizations, impaired quality of life…), for the family and for society. Improved understanding of the underlying reasons will help to form intervention strategies relevant to the context. OBJECTIVES: We aimed to assess medication adherence among stable patients suffering from schizophrenia and to identify factors associated with non-adherence...
September 20, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27649360/adrenaline-instead-of-amphetamine-replacing-psychoactive-substances-with-parachute-jumps
#10
Ryszard Makarowski, Piotr Makarowski, Zbigniew Kamiński
The "Adrenaline Instead of Amphetamine" program was launched by Gdańsk's MONAR association-a center for drug treatment. The purpose of the program was to show some alternatives to using psychoactive substances and to propose replacing these anti-medical behaviors with parachuting. The treatment effectiveness in this center is about 30%, and the program's effectiveness was 80%.
October 2016: Journal of General Psychology
https://www.readbyqxmd.com/read/27638057/analytically-confirmed-intoxications-involving-mdmb-chmica-from-the-strida-project
#11
Matilda Bäckberg, Luiza Tworek, Olof Beck, Anders Helander
INTRODUCTION: About a decade ago, synthetic cannabinoids (SC) started to appear as recreational drugs on the new psychoactive substance (NPS) market. This report from the STRIDA project describes analytically confirmed intoxications involving MDMB-CHMICA (methyl-2-(1-(cyclohexylmethyl)-1H-indol-3-ylcarbonylamino)-3,3-dimethylbutanoate), a SC that was first detected in 2014. STUDY DESIGN: This is an observational case series of patients from Sweden with suspected NPS exposure presenting in emergency departments and intensive care units...
September 16, 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27623834/-cocaine-characteristics-and-addiction
#12
REVIEW
Katarzyna Girczys-Połedniok, Robert Pudlo, Magdalena Jarząb, Agnieszka Szymlak
Cocaine use leads to health, social and legal problems. The aim of this paper is to discuss cocaine action, addicts characteristics, use patterns and consequences, as well as addiction treatment methods. A literature review was based on the Medline, PubMed, Polish Medical Bibliography databases and the Silesian Library resources. The Police and Central Statistical Office statistics, as well as the World Health Organization, the European Monitoring Centre for Drugs and Drug Addiction and the National Office for Combating Drug Addiction reports were used...
2016: Medycyna Pracy
https://www.readbyqxmd.com/read/27599617/polysubstance-induced-relapse-of-schizoaffective-disorder-refractory-to-high-dose-antipsychotic-medications-a-case-report
#13
Murray G Tucker, Sebastian Kekulawala, Michelle Kent, Sam Mostafa, Richard Harvey
BACKGROUND: The high prevalence of comorbid illicit drug use in persons with chronic psychotic illness represents a strong determinant of psychotic relapse and rehospitalization. Epidemiological studies indicate changing patterns of illicit drug use in Australia, which are concerning because of increased use of crystal methamphetamine, also known as "ice." An important complication of habitual use of crystal methamphetamine is the development of a dose-dependent acute psychotic reaction...
September 6, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27582720/drugs-as-instruments-describing-and-testing-a-behavioral-approach-to-the-study-of-neuroenhancement
#14
Ralf Brand, Wanja Wolff, Matthias Ziegler
Neuroenhancement (NE) is the non-medical use of psychoactive substances to produce a subjective enhancement in psychological functioning and experience. So far empirical investigations of individuals' motivation for NE however have been hampered by the lack of theoretical foundation. This study aimed to apply drug instrumentalization theory to user motivation for NE. We argue that NE should be defined and analyzed from a behavioral perspective rather than in terms of the characteristics of substances used for NE...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27568897/urine-toxicology-in-adults-evaluated-for-a-central-hypersomnia-and-how-the-results-modify-the-physician-s-diagnosis
#15
Christopher A Kosky, Anastasios Bonakis, Arthee Yogendran, Gihan Hettiarachchi, Paul I Dargan, Adrian J Williams
STUDY OBJECTIVES: Drugs and psychoactive substances can cause sleepiness and when undetected, may lead to over diagnosis of central hypersomnias. We performed urine drug testing using gas chromatography-mass spectrometry in adults undergoing multiple sleep latency testing (MSLT) for a suspected central hypersomnia. We examined how the drug test results modified the treating physician's diagnosis. METHODS: One hundred eighty-six consecutive patients with a suspected central hypersomnia who underwent clinical assessment, MSLT and urine drug testing by gas chromatography-mass spectrometry were retrospectively studied...
November 15, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27535017/characterization-and-in-vitro-phase-i-microsomal-metabolism-of-designer-benzodiazepines-an-update-comprising-adinazolam-cloniprazepam-fonazepam-3-hydroxyphenazepam-metizolam-and-nitrazolam
#16
Bjoern Moosmann, Philippe Bisel, Florian Franz, Laura M Huppertz, Volker Auwärter
Designer benzodiazepines represent an emerging class of new psychoactive substances (NPS). While other classes of NPS such as cannabinoid receptor agonists and designer stimulants are mainly consumed for hedonistic reasons, designer benzodiazepines may also be consumed as 'self-medication' by persons with anxiety or other psychiatric disorders or as stand-by 'antidote' by users of stimulant and hallucinogenic drugs. In the present study, five benzodiazepines (adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, and nitrazolam) and one thienodiazepine (metizolam) offered as 'research chemicals' on the Internet were characterized and their main in vitro phase I metabolites tentatively identified after incubation with pooled human liver microsomes...
August 17, 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/27484692/are-alcohol-anti-relapsing-and-alcohol-withdrawal-drugs-useful-in-cannabinoid-users
#17
Patrycja Kleczkowska, Irena Smaga, Małgorzata Filip, Magdalena Bujalska-Zadrozny
Cannabinoids are still classified as illegal psychoactive drugs despite their broad and increasingly acknowledged therapeutic potential. These substances are most famous for their wide recreational use, particularly among young adults to either alter the state of consciousness, intensify pleasure induced by other psychoactive substances or as an alternative to the previously abused drugs. It is important to emphasize that cannabinoids are often taken together with a variety of medications intended for the treatment of alcohol use disorder (AUD) or alcohol withdrawal syndrome (AWS)...
November 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27471990/ocfentanil-overdose-fatality-in-the-recreational-drug-scene
#18
Vera Coopman, Jan Cordonnier, Marc De Leeuw, Vincent Cirimele
This paper describes the first reported death involving ocfentanil, a potent synthetic opioid and structure analogue of fentanyl abused as a new psychoactive substance in the recreational drug scene. A 17-year-old man with a history of illegal substance abuse was found dead in his home after snorting a brown powder purchased over the internet with bitcoins. Acetaminophen, caffeine and ocfentanil were identified in the powder by gas chromatography mass spectrometry and reversed-phase liquid chromatography with diode array detector...
September 2016: Forensic Science International
https://www.readbyqxmd.com/read/27456262/acute-toxicity-associated-with-use-of-5f-derivations-of-synthetic-cannabinoid-receptor-agonists-with-analytical-confirmation
#19
Rachelle Abouchedid, James H Ho, Simon Hudson, Alison Dines, John R H Archer, David M Wood, Paul I Dargan
INTRODUCTION: Synthetic Cannabinoid Receptor Agonists (SCRAs) are the largest group of new psychoactive substances reported to the European Warning System and the United Nations Office on Drugs and Crime to date. The heterogeneous nature and speed of diversification of these compounds make it challenging to accurately characterise and predict harms of these compounds in pre-clinical studies, ahead of their appearance. CASE REPORT: We report the case of a 19-year-old female who purchased three products from a headshop: two new psychoactive substances (sachets of "cannabis tea" and "mushroom tea") as well as two LSD blotters...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27434697/small-molecule-detection-in-saliva-facilitates-portable-tests-of-marijuana-abuse
#20
Jung-Rok Lee, Joohong Choi, Tyler O Shultz, Shan X Wang
As medical and recreational use of cannabis, or marijuana, becomes more prevalent, law enforcement needs a tool to evaluate whether drivers are operating vehicles under the influence of cannabis, specifically the psychoactive substance, tetrahydrocannabinol (THC). However, the cutoff concentration of THC that causes impairment is still controversial, and current on-site screening tools are not sensitive enough to detect trace amounts of THC in oral fluids. Here we present a novel sensing platform that employs giant magnetoresistive (GMR) biosensors integrated with a portable reader system and smartphone to detect THC in saliva using competitive assays...
August 2, 2016: Analytical Chemistry
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