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https://www.readbyqxmd.com/read/29452245/haploidentical-bone-marrow-transplantation-with-post-transplant-cyclophosphamide-using-non-first-degree-related-donors
#1
Hany Elmariah, Yvette L Kasamon, Marianna Zahurak, Karen W Macfarlane, Noah Tucker, Gary L Rosner, Javier Bolaños-Meade, Ephraim J Fuchs, Nina Wagner-Johnston, Lode J Swinnen, Carol Ann Huff, William H Matsui, Douglas E Gladstone, Shannon R McCurdy, Ivan Borrello, Christian B Gocke, Satish Shanbhag, Kenneth R Cooke, Syed Abbas Ali, Robert A Brodsky, Amy E DeZern, Leo Luznik, Richard J Jones, Richard F Ambinder
Outcomes of nonmyeloablative (NMA) haploidentical (haplo) blood or marrow transplant (BMT) with post-transplantation cyclophosphamide (PTCy) using non-first-degree relatives are unknown. We evaluated 33 consecutive adult patients (median age 56 years) with hematologic malignancies who underwent NMA haplo T-cell replete BMT with PTCy at Johns Hopkins using second- or third-degree related donors. Donors consisted of 10 nieces (30%), 9 nephews (27%), 7 first cousins (21%), 5 grandchildren (15%), and 2 uncles (6%)...
February 13, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29447888/pathogenesis-of-chronic-rhinosinusitis-in-patients-affected-by-%C3%AE-thalassemia-major-and-sickle-cell-anaemia-post-allogenic-bone-marrow-transplant
#2
F Martino, R Di Mauro, K Paciaroni, J Gaziev, C Alfieri, L Greco, R Floris, S Di Girolamo, M Di Girolamo
OBJECTIVES: Sickle cell anemia (SCA) and β -thalassemia major are well-recognized beta-globin gene disorders of red blood cells associated to mortality and morbidity included bone morbidities due to ineffective erythropoiesis and bone marrow expansion, which affect every part of the skeleton. While there are an abundance of described disease manifestations of the head and neck, the manner of paranasal sinuses involvement and its relations to β-thalassemia and SCA process was not studied yet...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29432889/best-medical-treatment-and-selective-stent-graft-repair-for-acute-type-b-aortic-intramural-hematoma
#3
Gabriele Piffaretti, Chiara Lomazzi, Filippo Benedetto, Narayana Pipitò, Patrizio Castelli, Santi Trimarchi, Walter Dorigo, Matteo Tozzi
OBJECTIVES: To describe our experience with the management and the results of stent-graft (SG) repair of acute type B aortic intramural hematoma (B-IMH). METHODS: Between January 2005 and July 2016, we identified 41 B-IMHs. Major end-points were early and long-term survival, aortic remodeling, freedom from aortic-related mortality (ARM), and freedom from reintervention. RESULTS: Thirty-one (76%) patients eventually underwent SG repair: 16 (52%) cases in the acute phase, and 6 (19%) in the subacute (14-30 days) phase...
February 9, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29422477/parental-presence-absence-in-the-dental-operatory-as-a-behavior-management-technique-a-review-and-modified-view
#4
Hicham Riba, Asma Al-Shahrani, Hayat Al-Ghutaimel, Adel Al-Otaibi, Salim Al-Kahtani
INTRODUCTION: Parental presence/absence in the dental operatory (also called: Parent-in-parent-out technique) is an extremely controversial aspect of the nonpharmacological BMTs. Historically, dentists used to exclude parents from dental operatory to avoid their interference with the dentist's aptitude to build a rapport and relationship with the child, hence increasing the child management problems by disrupting treatment and making the dentist unfocused and uncomfortable. AIM: The purpose of this article is to review and emphasize on the importance of parental presence/absence in the dental operatory, especially in a certain age group, as a behavior management technique (BMT) in pediatric dentistry, and to present a modified view of this technique...
February 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29416817/transplants-of-unrelated-cord-blood-or-sibling-allogeneic-peripheral-blood-stem-cells-bone-marrow-in-adolescent-and-young-adults-with-chronic-myeloid-leukemia-comparable-outcomes-but-better-chronic-gvhd-free-and-relapse-free-survival-among-survivors-with-cord
#5
Changcheng Zheng, Xiaoyu Zhu, Baolin Tang, Xuhan Zhang, Lei Zhang, Liangquan Geng, Huilan Liu, Zimin Sun
Adolescent and young adult (AYA) patients with hematological malignancy aged 15 to 39 years are recognized as a separate entity, and the efficacy and safety of unrelated cord blood transplantation (CBT) for chronic myeloid leukemia (CML) in AYA patients has not been reported. From March 2002 to June 2015, total of 106 CML patients received allogeneic hematopoietic cell transplantation (allo-HCT) in our center. Included in the present study were CML patients aged 15 to 39 years who received unrelated CBT or sibling allo-HCT, and 74 consecutive AYA patients with CML enrolled in this analysis...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29410536/acute-appendicitis-in-leukaemia-patients-undergoing-haematopoietic-stem-cell-transplantation-during-the-neutropaenic-phase-a-case-series-from-a-single-bmt-centre-in-china
#6
Q Zhang, Y Zhou, J K Majaw, J Xu, Z Wei, Q Mai, C Zou, Y Zhang, Z Fan, F Huang, J Sun, Q Liu, Q Jiang
No abstract text is available yet for this article.
February 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29410535/corrigendum-disease-status-is-a-more-reliable-predictive-factor-than-histology-in-lymphoma-patients-after-reduced-intensity-conditioning-regimen-and-allo-sct
#7
L Castagna, R Boubdallah, S Furst, D Coso, J El Cheikh, C Faucher, R Crocchiolo, A Granata, C Chabannon, C Lemarié, B Calmels, J M Boher, M Mohty, D Blaise
This corrects the article DOI: 10.1038/bmt.2012.225.
February 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29399409/development-of-chimeric-antigen-receptors-targeting-t-cell-malignancies-using-two-structurally-different-anti-cd5-antigen-binding-domains-in-nk-and-crispr-edited-t-cell-lines
#8
Sunil S Raikar, Lauren C Fleischer, Robert Moot, Andrew Fedanov, Na Yoon Paik, Kristopher A Knight, Christopher B Doering, H Trent Spencer
Relapsed T-cell malignancies have poor outcomes when treated with chemotherapy, but survival after allogeneic bone marrow transplantation (BMT) approaches 50%. A limitation to BMT is the difficulty of achieving remission prior to transplant. Chimeric antigen receptor (CAR) T-cell therapy has shown successes in B-cell malignancies. This approach is difficult to adapt for the treatment of T-cell disease due to lack of a T-lymphoblast specific antigen and the fratricide of CAR T cells that occurs with T-cell antigen targeting...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29397835/-establishment-of-a20-murine-b-lymphoma-transplantation-model-labeled-with-luciferase
#9
Sha-Sha Zhao, Li-Xun Guan, Zhe Gao, Fei-Yan Wang, Li-Li Wang, Chun-Ji Gao
OBJECTIVE: To establish the animal model of luciferase-transfected A20 murine B cell lymphoma, so as to provide experimental tools to explore the effect of graft versus tumor. METHODS: Luciferase- labeled A20 cells were cloned with puromycin selection. Transfected A20 cells and C57BL/6 bone marrow were inoculated into the irradiated BALB/c mice by injection in tailvein to establish the transplantation model. The bioluminescent imaging technique was used to monitor the tumor growth, and then the survival, body weight, tumor formation and pathological characteristics of target organs were observed...
February 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29391546/the-gs-nitroxide-jp4-039-improves-intestinal-barrier-and-stem-cell-recovery-in-irradiated-mice
#10
Liang Wei, Brian J Leibowitz, Michael Epperly, Cheng Bi, Allen Li, Justin Steinman, Peter Wipf, Song Li, Lin Zhang, Joel Greenberger, Jian Yu
Total body irradiation (TBI) leads to dose- and tissue-specific lethality. In the current study, we demonstrate that a mitochondrion-targeted nitroxide JP4-039 given once 24 hours after 9-10 Gy TBI significantly improves mouse survival, and the recovery of intestinal barrier, differentiation and stem cell functions. The GI-protective effects are associated with rapid and selective induction of tight junction proteins and cytokines including TGF-β, IL-10, IL-17a, IL-22 and Notch signaling long before bone marrow depletion...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29388675/influenza-vaccines-in-immunosuppressed-adults-with-cancer
#11
REVIEW
Roni Bitterman, Noa Eliakim-Raz, Inbal Vinograd, Anca Zalmanovici Trestioreanu, Leonard Leibovici, Mical Paul
BACKGROUND: This is an update of the Cochrane review published in 2013, Issue 10.Immunosuppressed cancer patients are at increased risk of serious influenza-related complications. Guidelines, therefore, recommend influenza vaccination for these patients. However, data on vaccine effectiveness in this population are lacking, and the value of vaccination in this population remains unclear. OBJECTIVES: To assess the effectiveness of influenza vaccine in immunosuppressed adults with malignancies...
February 1, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29380715/the-need-to-support-caregivers-during-pediatric-bone-marrow-transplantation-bmt-a-case-report
#12
Christina Mangurian, Wendy Packman, Nicholas S Riano, Julia Kearney
OBJECTIVE: Pediatric bone marrow transplants represent a medically stressful, potentially traumatic experience for children and caregivers, and psychological support for parental caregivers is paramount to their long-term well-being. However, many medical centers do not have protocols in place to sustain caregiver well-being during these distressing experiences. METHOD: We report on a case of a 10-month-old infant with Wiskott Aldrich Syndrome who was hospitalized for bone marrow transplantation...
January 30, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29367710/the-japan-marrow-donor-program-25-years-of-experience-in-achieving-20-000-bone-marrow-transplantations-organization-structure-activity-and-financial-basis
#13
Hidehiko Saito, Masaharu Ito, Shunichi Kato, Yoshihisa Kodera, Shinichiro Okamoto, Shuichi Taniguchi, Minoko Takanashi, Heiwa Kanamori, Toru Masaoka, Fumimaro Takaku
The Japan Marrow Donor Program (JMDP), established in 1991, has continued to grow in its capacity to facilitate unrelated bone marrow (BMT) and peripheral blood stem cell transplantation (PBSCT) for the past 25 years in Japan. The current donor pool is 463,465 (as of 31 December 2016) and 20,237 transplants were performed with the help of the Japanese Red Cross, government, and supporters. As JMDP introduced PBSCT in 2010, the vast majority of transplants are BMT. All donors are fully typed for HLA-A, B, C, and DR...
January 24, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29367429/flt-3l-expansion-of-recipient-cd8%C3%AE-dendritic-cells-deletes-alloreactive-donor-t-cells-and-represents-an-alternative-to-post-transplant-cyclophosphamide-for-the-prevention-of-gvhd
#14
Kate Markey, Rachel D Kuns, Daniel J Browne, Kate H Gartlan, Renee J Robb, J Paulo Martins, Andrea S Henden, Simone A Minnie, Melody Cheong, Motoko Koyama, Mark J Smyth, Raymond J Steptoe, Gabrielle Belz, Thomas Brocker, Mariapia A Degli-Esposti, Steven W Lane, Geoffrey R Hill
PURPOSE: Allogeneic bone marrow transplantation (BMT) provides curative therapy for leukemia via immunological graft-versus-leukemia (GVL) effects. In practice, this must be balanced against life threatening pathology induced by graft-versus-host disease (GVHD). Recipient dendritic cells (DC) are thought to be important in the induction of GVL and GVHD. EXPERIMENTAL DESIGN: We have utilized preclinical models of allogeneic BMT to dissect the role and modulation of recipient DC in controlling donor T cell mediated GVHD and GVL...
January 24, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29366434/screening-for-asymptomatic-clostridium-difficile-among-bone-marrow-transplant-patients-a-mixed-methods-study-of-intervention-effectiveness-and-feasibility
#15
Anna K Barker, Benjamin Krasity, Jackson Musuuza, Nasia Safdar
OBJECTIVE To identify facilitators and barriers to implementation of a Clostridium difficile screening intervention among bone marrow transplant (BMT) patients and to evaluate the clinical effectiveness of the intervention on the rate of hospital-onset C. difficile infection (HO-CDI). DESIGN Before-and-after trial SETTING A 505-bed tertiary-care medical center PARTICIPANTS All 5,357 patients admitted to the BMT and general medicine wards from January 2014 to February 2017 were included in the study. Interview participants included 3 physicians, 4 nurses, and 4 administrators...
February 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29360515/choosing-wisely-bmt-american-society-for-blood-and-marrow-transplantation-and-canadian-blood-and-marrow-transplant-group-s-list-of-five-tests-and-treatments-to-question-in-blood-and-marrow-transplantation
#16
REVIEW
Sita Bhella, Navneet S Majhail, Jeffrey Betcher, Luciano J Costa, Andrew Daly, Christopher E Dandoy, Zachariah DeFilipp, Vi Doan, Alison Gulbis, Lisa Hicks, Mark Juckett, Nandita Khera, Amrita Krishnan, George Selby, Nirav N Shah, Melisa Stricherz, Auro Viswabandya, Christopher Bredeson, Matthew D Seftel
Choosing Wisely encourages dialogue about reducing unnecessary procedures, tests, or treatments in healthcare. The American Society for Blood and Marrow Transplantation (ASBMT) and Canadian Blood and Marrow Transplant Group (CBMTG) established a Choosing Wisely BMT Task Force whose objective was to create a list of top five practices in blood and marrow transplantation to be questioned. The Task Force consisted of representatives from ASBMT's Quality Outcomes, Education, and Practice Guidelines Committees, ASBMT's Pharmacy Special Interest Group, CBMTG Program Directors, and Center for International Blood and Marrow Transplant Research (CIBMTR)...
January 19, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29359939/strong-hydrogen-bonds-at-the-interface-between-proton-donating-and-accepting-self-assembled-monolayers-on-au-111
#17
Hiroyuki S Kato, Shinya Yoshimoto, Akira Ueda, Susumu Yamamoto, Yusuke Kanematsu, Masanori Tachikawa, Hatsumi Mori, Jun Yoshinobu, Iwao Matsuda
Hydrogen-bonding heterogeneous bilayers on substrates have been studied as a base for new functions of molecular adlayers by means of atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), infrared reflection absorption spectroscopy (IRAS), and density functional theory (DFT) calculations. Here, we report the formation of the catechol-fused bis(methylthio)tetrathiafulvalene (H2Cat-BMT-TTF) adlayer hydrogen bonding with an imidazole-terminated alkanethiolate self-assembled monolayer (Im-SAM) on Au(111)...
January 23, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29353808/determination-of-polymeric-impurities-in-asunaprevir-drug-substance-and-product-using-size-exclusion-effect-of-reversed-phase-columns
#18
Zongyun Huang, Yue Hu, Yan Zha, Robert Perrone, Joan Ruan, William P Fish
This paper describes the development of a simple reversed-phase HPLC method that can quantitate trace amounts of a polymeric degradants (BMT-041910) in asunaprevir drug substance and formulated drug product with quantitation limits of ∼0.05% w/w. The method has overcome several challenges of polymer quantitation such as band broadening, peak coeluting and low sensitivity. The hydrophobic function group (BOC) of BMT-041910 is removed to increase its aqueous solubility by a simple sample treatment procedure (des-BOC)...
January 11, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29353109/shortened-duration-tacrolimus-after-nonmyeloablative-hla-haploidentical-bmt
#19
Yvette L Kasamon, Ephraim J Fuchs, Marianna Zahurak, Gary L Rosner, Heather J Symons, Douglas E Gladstone, Carol Ann Huff, Lode J Swinnen, Robert A Brodsky, William H Matsui, Ivan Borrello, Satish Shanbhag, Kenneth R Cooke, Richard F Ambinder, Leo Luznik, Javier Bolaños-Meade, Richard J Jones
With posttransplantation cyclophosphamide (PTCy) as graft-versus-host disease (GVHD) prophylaxis, nonmyeloablative HLA-haploidentical (NMA haplo) and HLA-matched blood or marrow transplantation (BMT) have comparable outcomes. Early discontinuation of immunosuppression may reduce relapse, as well as improve immune reconstitution, but may increase GVHD. We conducted a prospective trial of NMA haplo BMT for patients with hematologic malignancies (median age, 61), evaluating the safety of early discontinuation of tacrolimus...
January 15, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29335629/a-prospective-randomized-evaluation-of-the-feasibility-of-exergaming-on-patients-undergoing-hematopoietic-stem-cell-transplantation
#20
Helge Schumacher, Sabrina Stüwe, Peter Kropp, Doreen Diedrich, Sebastian Freitag, Nico Greger, Christian Junghanss, Mathias Freund, Inken Hilgendorf
The positive effects of physical and sports therapy for strain dependent physical practice and improved quality of life (QoL) are well known. Nevertheless, the available capacities and problem-oriented therapies in the setting of hematopoietic stem cell transplantation (HSCT) are limited. We conducted a prospective, randomized study among 42 HSCT recipients in order to investigate the influence of exergaming on Nintendo Wii® or classical physiotherapy (PT) on physical fitness and psychological well-being. The trial included evaluation of muscle strength, endurance, physical activity, distress, QoL, anxiety, and depression...
January 15, 2018: Bone Marrow Transplantation
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