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https://www.readbyqxmd.com/read/29664513/vitiligo-type-cutaneous-manifestation-of-chronic-graft-versus-host-disease-case-report
#1
Karla Gálvez, Paula Muñoz, Valentina Vera, Claudio Arce
INTRODUCTION: Graft-versus-host disease (GVHD) is caused by a pathologic and destructive response of the organism as a result of the interaction between donor immunocompetent T lymphocytes and the recipient tisular antigens. It's considered the most serious complication of hematopoietic stem cell transplantation, most frequently described after bone marrow transplantation (BMT). The skin is usually the first and most commonly affected organ, in both acute and chronic, with a variable clinical spectrum of presentation...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29664112/efficacy-of-d-red-blood-cell-transfusion-and-rituximab-therapy-in-autoimmune-hemolytic-anemia-with-anti-d-and-panreactive-autoantibodies-arising-after-hematopoietic-stem-cell-transplant
#2
Keiji Minakawa, Hitoshi Ohto, Hiroyasu Yasuda, Shunichi Saito, Kinuyo Kawabata, Kazuei Ogawa, Kenneth E Nollet, Kazuhiko Ikeda
BACKGROUND: Autoimmune hemolytic anemia (AIHA) is caused by autoantibodies to red blood cells (RBCs), which can be panreactive and/or specific to Rh/other blood group antigens. We report a severe case of AIHA after bone marrow transplantation (BMT) due to autoanti-D triggered by reactivation of Epstein-Barr virus (EBV) infection. A combined strategy of D- RBC transfusion and administration of anti-CD20 monoclonal antibody (MoAb) resolved the hemolysis. CASE REPORT: A 33-year-old male underwent allogeneic BMT from an ABO-identical and HLA-matched unrelated male donor...
April 17, 2018: Transfusion
https://www.readbyqxmd.com/read/29661789/late-mortality-after-autologous-blood-or-marrow-transplantation-in-childhood-a-bmtss-2-report
#3
Anna Sällfors Holmqvist, Yanjun Chen, Jessica Wu, Kevin Battles, Ravi Bhatia, Liton Francisco, Lindsey Hageman, Michelle Kung, Emily Ness, Mariel Parman, Donna Salzman, Jeanette Falck Winther, Joseph Rosenthal, Stephen J Forman, Daniel J Weisdorf, Mukta Arora, Saro H Armenian, Smita Bhatia
Autologous BMT is a curative option for several types of childhood cancer. However, there is paucity of information regarding their risk of late mortality. We examined all-cause, relapse-related [RRM] and non-relapse-related [NRM] mortality in 2-year survivors of autologous BMT performed before age 22 between 1980 and 2010 at one of two U.S. transplant centers. Vital status information was collected using medical records, National Death Index, and Accurint databases. Overall survival was calculated using Kaplan-Meier techniques...
April 16, 2018: Blood
https://www.readbyqxmd.com/read/29660960/are-functional-mobility-tests-responsive-to-group-physical-therapy-intervention-in-individuals-with-parkinson-s-disease
#4
Gessyca Spagnuolo, Christina D C M Faria, Bruna Adriana da Silva, Angélica Cristiane Ovando, Joyce Gomes-Osman, Alessandra Swarowsky
BACKGROUND: The Timed up and go test (TUG), the Five times sit-to-stand test (FTSTS) and the Bed Mobility test (BMT) are widely used in clinical practice for Parkinson Disease (PD). However, no reported studies have evaluated the responsiveness to group physical therapy intervention (GPTI). OBJECTIVE: To verify if TUG, FTSTS and BMT were responsive to GPTI. METHODS: Thirty individuals with PD were assessed prior to and after an 8-week evidence-based GPTI...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29649435/food-for-gut-microbiota-fuels-immune-reconstitution-after-bmt
#5
Tiffany R Simms-Waldrip, Andrew Y Koh
The host factors that modulate hematopoietic reconstitution after bone marrow transplantation are poorly understood. In this issue of Cell Host & Microbe, Staffas et al. (2018) demonstrate that gut microbiota play a critical role in immune reconstitution after bone marrow transplantation, partly through dietary energy harvest and uptake.
April 11, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29642677/selection-response-and-estimation-of-the-genetic-parameters-for-multidimensional-measured-breast-meat-yield-related-traits-in-a-long-term-breeding-pekin-duck-line
#6
Yaxi Xu, Jian Hu, Yunsheng Zhang, Zhanbao Guo, Wei Huang, Ming Xie, Hehe Liu, Shuisheng Hou, Zhengkui Zhou, Chuzhao Lei, Xiaolin Liu
Objective: This study was conducted to estimate the genetic parameters and breeding values of breast meat related traits of Pekin ducks. Selection response was also determined by using ultrasound breast muscle thickness (BMT) measurements in combination with bosom breadth (BB) and keel length (KL) values. Methods: The traits analyzed were breast meat weight (BMW), body weight (BW), breast meat percentage (BMP) and the three parameters of breast meat (BB, KL, and BMT)...
April 12, 2018: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29629900/recipient-mucosal-associated-invariant-t-cells-control-gvhd-within-the-colon
#7
Antiopi Varelias, Mark D Bunting, Kate L Ormerod, Motoko Koyama, Stuart D Olver, Jasmin Straube, Rachel D Kuns, Renee J Robb, Andrea S Henden, Leanne Cooper, Nancy Lachner, Kate H Gartlan, Olivier Lantz, Lars Kjer-Nielsen, Jeffrey Yw Mak, David P Fairlie, Andrew D Clouston, James McCluskey, Jamie Rossjohn, Steven W Lane, Philip Hugenholtz, Geoffrey R Hill
Mucosal-associated invariant T (MAIT) cells are a unique innate-like T cell subset that responds to a wide array of bacteria and yeast through recognition of riboflavin metabolites presented by the MHC class I-like molecule MR1. Here, we demonstrate using MR1 tetramers that recipient MAIT cells are present in small but definable numbers in graft-versus-host disease (GVHD) target organs and protect from acute GVHD in the colon following bone marrow transplantation (BMT). Consistent with their preferential juxtaposition to microbial signals in the colon, recipient MAIT cells generate large amounts of IL-17A, promote gastrointestinal tract integrity, and limit the donor alloantigen presentation that in turn drives donor Th1 and Th17 expansion specifically in the colon after BMT...
April 9, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29617362/a-novel-approach-to-improve-immune-effector-responses-post-transplant-by-restoration-of-ccl21-expression
#8
Heather E Stefanski, Leslie Jonart, Emily Goren, James J Mulé, Bruce R Blazar
Chemotherapy or chemoradiotherapy conditioning regimens required for bone marrow transplantation (BMT) cause significant morbidity and mortality as a result of insufficient immune surveillance mechanisms leading to increased risks of infection and tumor recurrence. Such conditioning causes host stromal cell injury, impairing restoration of the central (thymus) and peripheral (spleen and lymph node) T cell compartments and slow immune reconstitution. The chemokine, CCL21, produced by host stromal cells, recruits T- and B-cells that provide lymphotoxin mediated instructive signals to stromal cells for lymphoid organogenesis...
2018: PloS One
https://www.readbyqxmd.com/read/29610366/exomechip-analyses-identify-genes-affecting-mortality-after-hla-matched-unrelated-donor-blood-and-marrow-transplantation
#9
Qianqian Zhu, Li Yan, Qian Liu, Chi Zhang, Lei Wei, Qiang Hu, Leah Preus, Alyssa I Clay-Gilmour, Kenan Onel, Daniel O Stram, Loreall Pooler, Xin Sheng, Christopher A Haiman, Xiaochun Zhu, Stephen R Spellman, Marcelo Pasquini, Philip L McCarthy, Song Liu, Theresa Hahn, Lara E Sucheston-Campbell
While survival outcomes have significantly improved, up to 40% of patients die within 1-year after HLA-matched unrelated donor (URD) blood and marrow transplant (BMT). To identify non-HLA genetic contributors to mortality after BMT, we performed the first exome-wide association study in the DISCOVeRY-BMT cohorts using the Illumina HumanExome BeadChip. This study includes 2,473 AML, ALL, MDS patients and 2,221 10/10 HLA matched donors treated from 2000-2011. Single variant and gene-level analyses were performed with overall survival (OS), transplant-related mortality (TRM), and disease-related mortality (DRM)...
April 2, 2018: Blood
https://www.readbyqxmd.com/read/29599809/electroacupuncture-at-st36-increases-bone-marrow-derived-interstitial-cells-of-cajal-via-the-sdf-1-cxcr4-and-mscf-kit-etv1-pathways-in-the-stomach-of-diabetic-mice
#10
Jiao Zhao, Jing An, Shi Liu
Background: The loss of interstitial cells of Cajal (ICC) is observed in diabetic gastroparesis. Electroacupuncture (EA) maintains ICC networks, but the effects and mechanisms of EA on ICC of bone marrow derivation in the stomach have not been investigated. Methods: C57BL/6 mice were randomized into six groups: control, diabetic (DM), bone marrow transplantation (BMT) + DM, BMT + DM + sham EA (SEA), BMT + DM + low-frequency EA (LEA), and BMT + DM + high-frequency (HEA)...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29587595/health-related-quality-of-life-before-and-after-hematopoietic-stem-cell-transplant-evidence-from-a-survey-in-suzhou-china
#11
Yongchun Liang, Haifang Wang, Meie Niu, Xiaming Zhu, Jianzheng Cai, Xiubei Wang
OBJECTIVES: The aim of our longitudinal study was to explore changes in HRQOL over a 6-month period and to identify factors associated with the HRQOL of HSCT recipients. METHOD: Our study comprised 191 HSCT patients; their data were collected before transplantation and at 30, 90, and 180 days posttransplantation. The Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) questionnaire was used to assess HRQOL.We also evaluated the patients' demographic characteristics and clinical histories to determine the relative contributions of these factors to HRQOL outcomes...
March 27, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29576480/nutritional-support-from-the-intestinal-microbiota-improves-hematopoietic-reconstitution-after-bone-marrow-transplantation-in-mice
#12
Anna Staffas, Marina Burgos da Silva, Ann E Slingerland, Amina Lazrak, Curtis J Bare, Corey D Holman, Melissa D Docampo, Yusuke Shono, Benjamin Durham, Amanda J Pickard, Justin R Cross, Christoph Stein-Thoeringer, Enrico Velardi, Jennifer J Tsai, Lorenz Jahn, Hillary Jay, Sophie Lieberman, Odette M Smith, Eric G Pamer, Jonathan U Peled, David E Cohen, Robert R Jenq, Marcel R M van den Brink
Bone marrow transplantation (BMT) offers curative potential for patients with high-risk hematologic malignancies, but the post-transplantation period is characterized by profound immunodeficiency. Recent studies indicate that the intestinal microbiota not only regulates mucosal immunity, but can also contribute to systemic immunity and hematopoiesis. Using antibiotic-mediated microbiota depletion in a syngeneic BMT mouse model, here we describe a role for the intestinal flora in hematopoietic recovery after BMT...
March 19, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29573075/plasmodium-falciparum-infection-transmitted-by-transfusion-a-cause-of-hemophagocytic-syndrome-after-bone-marrow-tranplantation-in-a-non-endemic-country
#13
Saloua Ladeb, Nour Ben Abdejlil, Najla Fakhfakh, Amel Lakhal, Dorra Belloumi, Leila Ben Hamed, Aicha Kallel, Lamia Torjman, Rym El Fatimi, Slama Hmida, Kalthoum Kallel, Tarek Ben Othman
A 27-year-old man with severe aplastic anemia underwent bone marrow transplantation from his HLA identical brother in July 2016. Conditioning included ATGAM 30 mg/kg for 3 days and Cyclophosphamide 50 mg/kg for 4 days. The patient received several platelet and red blood cell transfusions before and after the conditioning. The patient received broad spectrum antibiotics and caspofungin because persistant febrile neutropenia without bacteriological or mycological documentation. Hemophagocytic syndrome was diagnosed on day +12...
March 23, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29552987/outcomes-of-thoracic-endovascular-aortic-repair-for-acute-type-b-dissection-in-patients-with-intractable-pain-or-refractory-hypertension
#14
Liza Laquian, Salvatore T Scali, Thomas M Beaver, Paul Kubilis, Adam W Beck, Kristina Giles, Thomas S Huber, Robert J Feezor
PURPOSE: To compare uncomplicated acute type B aortic dissection (UATBAD) patients with intractable pain/refractory hypertension treated with thoracic endovascular aortic repair (TEVAR) to UATBAD subjects without these features receiving best medical therapy (BMT). METHODS: Interrogation of the hospital database identified 101 consecutive UATBAD patients admitted between January 2011 and December 2014. Of these, 74 patients (mean age 62±13 years; 44 men) were treated with BMT; the other 27 UATBAD patients (mean age 63±13 years; 17 men) were subsequently treated with TEVAR for intractable pain (24, 89%) and/or refractory hypertension (3, 11%) at a mean 2...
April 2018: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29547607/heparin-versus-normal-saline-flushing-effectiveness-in-managing-central-venous-catheters-in-patients-undergoing-blood-and-marrow-transplantation
#15
John Klein, Amelia Jepsen, Amy Patterson, Richard R Reich, Tina M Mason
BACKGROUND: Patients undergoing blood and marrow transplantation (BMT) use a central venous catheter (CVC); heparin is often employed to maintain patency but may increase the risk of complications. Research has not provided conclusive differences in efficacy and safety regarding heparin flushing versus normal saline flushing in CVC maintenance. Minimal research is specific to this patient population. OBJECTIVES: This study aimed to determine if differences exist in CVC patency, tissue plasminogen activator usage, and the incidence of central line-associated bloodstream infections when flushing with normal saline only versus heparin and normal saline among patients undergoing BMT...
April 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29545594/high-transplant-related-mortality-associated-with-haematopoietic-stem-cell-transplantation-for-paediatric-therapy-related-acute-myeloid-leukaemia-t-aml-a-study-on-behalf-of-the-united-kingdom-paediatric-blood-and-bone-marrow-transplant-group
#16
Adam Gassas, Ponni Sivaprakasam, Michelle Cummins, Patricia Breslin, Katharine Patrick, Mary Slatter, Roderick Skinner, Geof Shenton, Brenda Gibson, Sarah Lawson, Toni Petterson, Michael Potter, Beki James, Rachael Hough, Prashant Hiwarkar, Ajay Vora, Paul Veys, Josu De La Fuente, Robert Wynn, Persis Amrolia
Paediatric therapy-related acute myeloid leukaemia (t-AML) is rare and the outcome is poor. While allogeneic haematopoietic stem cell transplantation (HSCT) is generally the accepted modality of treatment, data regarding salvage chemotherapy, remission induction, conditioning regimens, transplant-related mortality and outcome is scarce. Between 2000 and2016, 36 children with t-AML were treated in seven UK paediatric HSCT centres. The most common salvage protocol for remission induction was FLAG with or without idarubicin and 28 patients were in complete morphological remission prior to BMT...
March 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29537491/pilot-study-of-a-multimodal-intervention-to-enhance-sexual-function-in-survivors-of-hematopoietic-stem-cell-transplantation
#17
Areej El-Jawahri, Sarah R Fishman, Julie Vanderklish, Don S Dizon, Nicole Pensak, Lara Traeger, Joseph A Greer, Elyse R Park, Netana Markovitz, Lauren Waldman, Chrisa Hunnewell, Meredith Saylor, Jessica Driscoll, Zhigang Li, Thomas R Spitzer, Steven McAfee, Yi-Bin Chen, Jennifer S Temel
BACKGROUND: Although sexual dysfunction is common after hematopoietic stem cell transplantation (HCT), interventions to address sexual function are lacking. METHODS: We conducted a pilot study to assess the feasibility and preliminary efficacy of a multimodal intervention to address sexual dysfunction in allogeneic HCT survivors. Transplant clinicians screened HCT survivors ≥3 months post-HCT for sexual dysfunction causing distress. Those who screened positive attended monthly visits with a trained transplant clinician who: 1) performed an assessment of the causes of sexual dysfunction; 2) educated and empowered the patient to address his or her sexual concerns; and 3) implemented therapeutic interventions targeting the patient's needs...
March 14, 2018: Cancer
https://www.readbyqxmd.com/read/29535395/systematic-review-and-network-meta-analysis-of-treatment-strategies-for-asymptomatic-carotid-disease
#18
Mohamed Barkat, Iain Roy, Stavros A Antoniou, Francesco Torella, George A Antoniou
We aim to perform a systematic review and meta-analysis to investigate outcomes of treatment strategies for asymptomatic carotid disease. We searched electronic bibliographic sources (MEDLINE, EMBASE, CINAHL and CENTRAL) to identify randomised controlled trials (RCT) reporting comparative outcomes of carotid endarterectomy (CEA), carotid stenting (CAS) and best medical therapy (BMT) in asymptomatic carotid disease. We performed pairwise meta-analysis applying random or fixed-effects models and reported the results as the odds ratio (OR) or risk difference (RD) and 95% confidence interval (CI)...
March 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29535105/filgrastim-enhances-t-cell-clearance-by-antithymocyte-globulin-exposure-after-unrelated-cord-blood-transplantation
#19
Coco de Koning, Julie-Anne Gabelich, Jurgen Langenhorst, Rick Admiraal, Jurgen Kuball, Jaap Jan Boelens, Stefan Nierkens
Residual antithymocyte globulin (ATG; Thymoglobulin) exposure after allogeneic hematopoietic (stem) cell transplantation (HCT) delays CD4+ T-cell immune reconstitution (CD4+ IR), subsequently increasing morbidity and mortality. This effect seems particularly present after cord blood transplantation (CBT) compared to bone marrow transplantation (BMT). The reason for this is currently unknown. We investigated the effect of active-ATG exposure on CD4+ IR after BMT and CBT in 275 patients (CBT n = 155, BMT n = 120; median age, 7...
March 13, 2018: Blood Advances
https://www.readbyqxmd.com/read/29534294/a-group-sequential-test-for-treatment-effect-based-on-the-fine-gray-model
#20
Michael J Martens, Brent R Logan
Competing risks endpoints arise when patients can fail therapy from several causes. Analyzing these outcomes allows one to assess directly the benefit of treatment on a primary cause of failure in a clinical trial setting. Regression models can be used in clinical trials to adjust for residual imbalances in patient characteristics, improving the power to detect treatment differences. But, none of the competing risks methods currently available for use in group sequential trials adjust for covariates. We propose a group sequential test for treatment effect that, because it is based on the Fine-Gray model, permits adjustment for covariates...
March 13, 2018: Biometrics
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