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https://www.readbyqxmd.com/read/29035398/risks-factors-and-timing-of-genital-human-papillomavirus-hpv-infection-in-female-stem-cell-transplant-survivors-a-longitudinal-study
#1
D Shanis, P Anandi, C Grant, A Bachi, N Vyas, M A Merideth, P A Pophali, E Koklanaris, S Ito, B N Savani, A J Barrett, M Battiwalla, P Stratton
This longitudinal single-center study describes the timing and risk factors for genital human papillomavirus (HPV) disease in women after allogeneic hematopoietic cell transplantation (HCT). Between 1994 and 2014, 109 females underwent HCT of whom 82 surviving transplant for >1 year had regular, comprehensive genital tract assessment and treatment of HPV disease. The cumulative proportions of any genital HPV infection at 1, 3, 5, 10 and 20 years were 4.8%, 14.9%, 28.1%, 36.7% and 40.9%, respectively. Demographic, disease-related factors, chronic GvHD (cGvHD) and its treatment were analyzed for their association with persistent, multifocal or severe genital HPV disease...
October 16, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29035395/replacing-carmustine-by-thiotepa-and-cyclophosphamide-for-autologous-stem-cell-transplantation-in-hodgkin-s-and-non-hodgkin-s-b-cell-lymphoma
#2
E Joffe, D Rosenberg, U Rozovski, C Perry, I Kirgner, S Trestman, O Gur, F Aviv, N Sarid, A Kolomansky, L Gepstein, Y Herishanu, E Naparstek
This study aimed to compare the real-life results of TECAM, a thiotepa-based conditioning regimen consisting of thiotepa (40 mg/m(2) days -5 to -2), etoposide (200 mg/m(2) days -6 to -3), cytarabine (200 mg/m(2) days -4 to -1), cyclophosphamide (60 mg/kg day -3), and melphalan (60 mg/m(2) days -2 to -1) with that of the conventional carmustine-based regimen BEAM. We reviewed 125 consecutive patients who underwent a first autologous transplantation (ASCT) for B-cell lymphomas at a large tertiary transplantation center between 1999 and 2014...
October 16, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29035394/infusion-of-autograft-natural-killer-cell-cd14-hla-dr-dim-cell-ratio-predicts-survival-in-lymphoma-post-autologous-stem-cell-transplantation
#3
A Kansagra, D J Inwards, S M Ansell, I N Micallef, P B Johnston, W J Hogan, S N Markovic, L F Porrata
The infusion of autograft absolute lymphocyte count (A-ALC) and autograft natural killer cells (A-NKC) are prognostic factors for overall survival (OS) and PFS in non-Hodgkin's lymphoma (NHL) patients undergoing autologous peripheral blood hematopoietic stem cell transplantation (APBHSCT). The human monocytic CD14(+)HLA-DR(DIM) cells are associated with worse prognosis in NHL. Thus, we investigated whether the autograft A-NKC/A-CD14(+)HLA-DR(DIM) ratio predicts survival in NHL. In a total of 111 NHL patients, we analyzed apheresis collection samples for the content of A-NKC and A-CD14(+)HLA-DR(DIM)...
October 16, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29035393/donor-lymphocyte-infusion-following-haploidentical-hematopoietic-cell-transplantation-with-peripheral-blood-stem-cell-grafts-and-ptcy
#4
S R Goldsmith, M Slade, J F DiPersio, P Westervelt, M A Schroeder, F Gao, R Romee
Donor-lymphocyte infusion (DLI) for relapse following haploidentical hematopoietic cell transplantation (haploHCT) with post-transplant cyclophosphamide (PTCy) has been described in recipients of bone marrow grafts, but not recipients of G-CSF mobilized peripheral blood (PB) grafts. We retrospectively identified patients who underwent DLI following PB-haploHCT with PTCy for relapse, or loss of chimerism (LOC). Twelve patients (57%) received DLI for hematologic relapse/persistent disease, seven (33%) for extramedullary relapse and two (10%) for LOC...
October 16, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29035392/long-term-outcome-of-mixed-chimerism-after-stem-cell-transplantation-for-thalassemia-major-conditioned-with-busulfan-and-cyclophosphamide
#5
N A Fouzia, E S Edison, K M Lakshmi, A Korula, S R Velayudhan, P Balasubramanian, A Abraham, A Viswabandya, B George, V Mathews, A Srivastava
Mixed chimerism (MC) occurs frequently after allogeneic hematopoietic stem cell transplantation (HSCT) for thalassemia major (TM) and may be associated with rejection. We report the outcome of MC in 132 TM patients conditioned with Busulphan/Cyclophosphamide, who had successful engraftment and had ⩾1 year follow-up. Chimerism was first assessed at day +28, then every 3-9 months or more frequently if there was MC. If rejection was suspected, immunosuppression was stopped and donor-lymphocyte infusion (DLI) was given if there was no response...
October 16, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29032271/a-comparative-assessment-of-quality-of-life-in-multiple-myeloma-patients-undergoing-autologous-stem-cell-transplantation-through-an-outpatient-and-inpatient-model
#6
Massimo Martino, Sabino Ciavarella, Simona De Summa, Letteria Russo, Nicola Meliambro, Lucrezia Imbalzano, Giuseppe Alberto Gallo, Tiziana Moscato, Giuseppe Messina, Anna Ferreri, Maria Cuzzola, Giuseppe Irrera, Virginia Naso, Michele Cimminiello, Giuseppe Console, Giacomo Loseto, Stefania Tommasi, Attilio Guarini
Outpatient autologous stem cell transplantation (ASCT) has been shown to be feasible in terms of physical morbidity and mortality outcomes, but few data exist on the quality of life (QoL) impact of delivering such approach in this manner. The purpose of this prospective, observational, longitudinal, cohort study was to compare effects of inpatient (n = 76) and outpatient (n = 64) modes of care on QoL in multiple myeloma patients who underwent ASCT. Patients were treated according to their preference for inpatient or outpatient model...
October 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29026154/associations-of-interactions-between-nlrp3-snps-and-hla-mismatch-with-acute-and-extensive-chronic-graft-versus-host-diseases
#7
Hidekazu Takahashi, Naoko Okayama, Natsu Yamaguchi, Yuta Miyahara, Yasuo Morishima, Yutaka Suehiro, Takahiro Yamasaki, Koji Tamada, Satoshi Takahashi, Arinobu Tojo, Shigetaka Asano, Tsuyoshi Tanabe
HLA matching is a well-known genetic requirement for successful bone marrow transplantation (BMT). However, the importance of non-HLA single-nucleotide polymorphisms (SNPs) remains poorly understood. The NLR family pyrin domain-containing 3 (NLRP3) inflammasome, a key regulator of innate immunity, is associated with multiple diseases. We retrospectively genotyped SNPs of NLRP1-3 and caspase recruitment domain family member 8 (CARD8), which are implicated in the interleukin 1β (IL-1β) signaling, in 999 unrelated BMT donor-recipient pairs...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28993772/rescuing-self-transient-isolation-and-autologous-transplantation-of-bone-marrow-mitigates-radiation-induced-hematopoietic-syndrome-and-mortality-in-mice
#8
Subhajit Ghosh, Namita Indracanti, Jayadev Joshi, Prem Kumar Indraganti
The inflamed bone marrow niche shortly after total body irradiation (TBI) is known to contribute to loss of hematopoietic stem cells in terms of their number and function. In this study, autologous bone marrow transfer (AL-BMT) was evaluated as a strategy for mitigating hematopoietic form of the acute radiation syndrome by timing the collection phase (2 h after irradiation) and reinfusion (24 h after irradiation) using mice as a model system. Collection of bone marrow (BM) cells (0.5 × 10(6) total marrow cells) 2 h after lethal TBI rescued different subclasses of hematopoietic stem and progenitor cells (HSPCs) from the detrimental inflammatory and damaging milieu in vivo...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28991252/population-pharmacokinetics-and-pharmacodynamics-of-mycophenolic-acid-using-the-prospective-data-in-patients-undergoing-hematopoietic-stem-cell-transplantation
#9
K Yoshimura, I Yano, T Yamamoto, M Kawanishi, Y Isomoto, A Yonezawa, T Kondo, A Takaori-Kondo, K Matsubara
Mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), is used to suppress GvHD in patients undergoing hematopoietic stem cell transplantation (HCT). The purpose of this study was to construct a population pharmacokinetic and pharmacodynamic model in HCT patients for individualized MPA therapy. Blood samples were obtained from 49 HCT patients after starting MMF therapy. Population pharmacokinetic and pharmacodynamic parameters were obtained using the program NONMEM. MPA was described via a one-compartment model with a first-order elimination, and 30...
October 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28991250/assessment-of-trec-krec-and-telomere-length-in-long-term-survivors-after-allogeneic-hsct-the-role-of-gvhd-and-graft-source-and-evidence-for-telomere-homeostasis-in-young-recipients
#10
A Gaballa, A Norberg, A Stikvoort, J Mattsson, B Sundberg, M Uzunel, M Remberger, M Uhlin
Reconstitution of the adaptive immune system following allogeneic hematopoietic stem cell transplantation is crucial for beneficial outcome and is affected by several factors, such as GvHD and graft source. The impact of these factors on immune reconstitution has been thoroughly investigated during the early phase after transplantation. However, little is known about their long-term effect. Similarly, leukocyte telomere length (TL) shortening has been reported shortly after transplantation. Nevertheless, whether TL shortening continues in long-term aspect is still unsettled...
October 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28991247/long-term-prognosis-for-1-year-relapse-free-survivors-of-cd34-cell-selected-allogeneic-hematopoietic-stem-cell-transplantation-a-landmark-analysis
#11
C Cho, M Hsu, P Barba, M A Maloy, S T Avecilla, J N Barker, H Castro-Malaspina, S A Giralt, A A Jakubowski, G Koehne, R C Meagher, R J O'Reilly, E B Papadopoulos, D M Ponce, R Tamari, M R M van den Brink, J W Young, S M Devlin, M-A Perales
CD34+ cell selection significantly improves GvHD-free survival in allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, specific information regarding long-term prognosis and risk factors for late mortality after CD34+ cell-selected allo-HSCT is lacking. We conducted a single-center landmark analysis in 276 patients alive without relapse 1 year after CD34+ cell-selected allo-HSCT for AML (n=164), ALL (n=33) or myelodysplastic syndrome (n=79). At 5 years' follow-up after the 1-year landmark (range 0...
October 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28991245/secondary-solid-cancer-following-hematopoietic-cell-transplantation-in-patients-with-thalassemia-major
#12
S Santarone, A Pepe, A Meloni, A Natale, L Pistoia, P Olioso, G Papalinetti, L Cuccia, A Spasiano, R Lisi, M Di Ianni, T Bonfini, P Accorsi, S Salvadori, F Papola, S Angelini, P Di Bartolomeo
Hematopoietic cell transplant (HCT) recipients have a substantial risk of developing secondary solid cancers (SSCs). The aim of this retrospective study was to compare the incidence of SSC in a monocentric cohort of thalassemia major (TM) patients (n=122) who received HCT versus an hematopoietic cell donor monocentric cohort (n=122) and versus a large multicenter cohort of age- and sex-matched TM patients (n=244) who received conventional therapy. With a median follow-up of 24 years, 8 transplanted patients were diagnosed with SSC at a median of 18 years after HCT and at a median age of 33 years...
October 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28990661/second-tympanostomy-tube-placement-in-children-with-recurrent-acute-otitis-media
#13
Phillip Huyett, Joshua J Sturm, Amber D Shaffer, Dennis J Kitsko, David H Chi
OBJECTIVES/HYPOTHESIS: To determine the rate and predictors of electing for a second bilateral myringotomy and tympanostomy tube placement (BMT) in children with recurrent acute otitis media (RAOM). STUDY DESIGN: Retrospective chart review. METHODS: Charts of 600 children who underwent BMT for RAOM between 2012 and 2014 were reviewed. RESULTS: The overall rate of a second BMT was 15.2% (91/600) and occurred a median of 1...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28983259/remission-of-psychosis-in-treatment-resistant-schizophrenia-following-bone-marrow-transplantation-a-case-report
#14
Tsuyoshi Miyaoka, Rei Wake, Sadayuki Hashioka, Maiko Hayashida, Arata Oh-Nishi, Ilhamuddin Abdul Azis, Muneto Izuhara, Keiko Tsuchie, Tomoko Araki, Ryosuke Arauchi, Rostia Arianna Abdullah, Jun Horiguchi
The authors present the case of a 24-year-old male with treatment-resistant schizophrenia, with predominant severe delusion and hallucination, who received bone marrow transplantation (BMT) for acute myeloid leukemia. After BMT, he showed a remarkable reduction in psychotic symptoms without administration of neuroleptics. He also showed drastic improvement in social functioning. Follow-up evaluations 2 and 4 years after BMT showed persistent significant improvement of the psychotic state and social functioning...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28972053/case-3-blood-bugs-and-a-bmt
#15
Lina Patel, Deepa Kulkarni
No abstract text is available yet for this article.
October 2017: Pediatrics in Review
https://www.readbyqxmd.com/read/28967899/hematopoietic-stem-cell-transplant-associated-thrombotic-microangiopathy-current-paradigm-and-novel-therapies
#16
REVIEW
J Khosla, A C Yeh, T R Spitzer, B R Dey
Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (TA-TMA) remains a difficult complication to address due to its high mortality rate, lack of standard diagnostic criteria and limited therapeutic options. Underscoring this challenge is the complex pathophysiology involved and multiple contributing factors that converge on a final pathway involving widespread endothelial injury and complement activation. In addressing our current understanding of TA-TMA, we highlight the risk factors leading to endothelial damage and a pathophysiological cascade that ensues...
October 2, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28967897/donor-t-cell-responses-and-disease-progression-patterns-of-multiple-myeloma
#17
M Eefting, L C de Wreede, P A Von dem Borne, C J M Halkes, S Kersting, E W A Marijt, H Putter, H Veelken, J Schetelig, J H F Falkenburg
Donor T-cells transferred after allogeneic stem cell transplantation (alloSCT) can result in long-term disease control in myeloma by the graft-versus-myeloma (GvM) effect. However, T-cell therapy may show differential effectiveness against bone marrow (BM) infiltration and focal myeloma lesions resulting in different control and progression patterns. Outcomes of 43 myeloma patients who underwent T-cell-depleted alloSCT with scheduled donor lymphocyte infusion (DLI) were analyzed with respect to diffuse BM infiltration and focal progression...
October 2, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28967896/post-autologous-transplant-maintenance-therapies-in-lymphoma-current-state-and-future-directions
#18
REVIEW
P A Riedell, M R Bishop
Disease relapse following high-dose chemotherapy and autologous stem cell transplant (ASCT) remains the principal cause of mortality in patients with relapsed or refractory lymphomas. In an effort to prevent post-ASCT relapse, a number of studies have evaluated the role of maintenance therapy with varying success. In diffuse large B-cell lymphoma, studies evaluating maintenance rituximab (MR) following ASCT failed to demonstrate improved outcomes. In follicular lymphoma, MR was associated with an improvement in PFS; however, no overall survival (OS) benefit was noted...
October 2, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28967895/associations-between-acute-gastrointestinal-gvhd-and-the-baseline-gut-microbiota-of-allogeneic-hematopoietic-stem-cell-transplant-recipients-and-donors
#19
C Liu, D N Frank, M Horch, S Chau, D Ir, E A Horch, K Tretina, K van Besien, C A Lozupone, V H Nguyen
Growing evidence suggests that host-microbiota interactions influence GvHD risk following allogeneic hematopoietic stem cell transplant. However, little is known about the influence of the transplant recipient's pre-conditioning microbiota nor the influence of the transplant donor's microbiota. Our study examines associations between acute gastrointestinal GvHD (agGvHD) and 16S rRNA fecal bacterial profiles in a prospective cohort of N=57 recipients before preparative conditioning, as well as N=22 of their paired HLA-matched sibling donors...
October 2, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28961460/bacillus-subtilis-disa-helps-to-circumvent-replicative-stress-during-spore-revival
#20
Marina Raguse, Rubén Torres, Elena M Seco, Carolina Gándara, Silvia Ayora, Ralf Moeller, Juan C Alonso
The mechanisms that allow to circumvent replicative stress, and to resume DNA synthesis are poorly understood in Bacillus subtilis. To study the role of the diadenylate cyclase DisA and branch migration translocase (BMT) RadA/Sms in restarting a stalled replication fork, we nicked and broke the circular chromosome of an inert mature haploid spore, damaged the bases, and measured survival of reviving spores. During undisturbed ripening, nicks and breaks should be repaired by pathways that do not invoke long-range end resection or genetic exchange by homologous recombination, after which DNA replication might be initiated...
September 22, 2017: DNA Repair
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