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"Cold-induced urticaria"

Terrance McGovern, Justin McNamee, Steven Marcus, Josh Kashani
Cyproheptadine is an H-1 antihistamine with anticholinergic and antiserotonergic effects. Cyproheptadine's most common use has been in the management cold-induced urticaria. It is often used in primary care for its side effect of appetite stimulation. Recently there has been increasing interest in its use in the treatment of drug-induced serotonin syndrome. Cyproheptadine overdose is uncommonly reported in the medical literature. We report the rare case of a pediatric cyproheptadine overdose with a confirmatory cyproheptadine level...
August 2017: Clinical practice and cases in emergency medicine
Michelle C Maciag, Charles Nargozian, Ana Dioun Broyles
No abstract text is available yet for this article.
April 4, 2018: Journal of Allergy and Clinical Immunology in Practice
Yael Gernez, Scott H Sicherer, Julie Wang
No abstract text is available yet for this article.
February 10, 2018: Journal of Allergy and Clinical Immunology in Practice
Paolo Romita, Paola Mascia, Gianfranco Calogiuri, Caterina Foti
BACKGROUND AND OBJECTIVE: The present review investigated cold-induced anaphylaxis, a potentially life-threatening condition that occurs after exposure to cold stimuli and is characterized by respiratory distress and/or hypotension. Anaphylaxis is rarely associated to cold-induced urticarial (CU), a particular form of physical urticaria that is difficult to diagnose and manage. The incidence of cold-induced urticaria has been estimated at about 0.05%, higher in colder regions and in women; its pathological mechanisms are still unknown...
July 3, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
Erin M Maddy, Joseph D Schmoker, William G Tharp, S Patrick Bender, Erik P Anderson, Jacob A Martin
No abstract text is available yet for this article.
October 2017: Journal of Cardiothoracic and Vascular Anesthesia
J C Alba Marín, A Martorell Aragones, P Satorre Viejo, E Gastaldo Simeon
No abstract text is available yet for this article.
2015: Journal of Investigational Allergology & Clinical Immunology
Michael G Fitzsimons, Gus Vlahakes, Robert Makar, Joshua Dilley, Cameron Wright, Elizabeth M Van Cott, Mandakolathur Murali
Acquired cold urticaria is a condition characterized by the onset of pruritic hives, swelling, and occasional severe systemic reactions, during the rewarming phase, after cold exposure. Pulmonary thromboendarterectomy (PTE) is a cardiac surgical procedure where organized thrombus is excised from the pulmonary vasculature in order to improve pulmonary blood flow and relieve pressure on the right ventricle. A PTE requires institution of deep hypothermic circulatory arrest (DHCA) in order to reduce blood flow from collateral vessels during thrombus excision...
August 2015: Annals of Thoracic Surgery
Jasmin B Kuemmerle-Deschner
The cryopyrin-associated periodic syndrome (CAPS) is a severity spectrum of rare diseases. CAPS comprises the three conditions previously described as familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disorder (NOMID), also known as chronic infantile neurologic, cutaneous, and articular (CINCA) syndrome. The clinical phenotype of CAPS is characterized by systemic inflammation. General symptoms are fatigue and fever. Local manifestations affect multiple tissues such as skin, joints, muscles, eyes, and the central nervous system...
July 2015: Seminars in Immunopathology
Bahar Torabi, Moshe Ben-Shoshan
Physical urticaria is often challenging to diagnose and manage. We present a case of both cholinergic and cold-induced urticaria and discuss the diagnosis and management strategies of these two important conditions.
February 18, 2015: BMJ Case Reports
Hirsh D Komarow, Sarah Arceo, Michael Young, Celeste Nelson, Dean D Metcalfe
BACKGROUND: Physical urticaria is a subtype of chronic urticaria induced by a physical stimulus. OBJECTIVE: To evaluate the consistency between a history of physical urticaria and results of challenge testing. METHODS: Seventy-six subjects, ages 3 to 77 years old, were referred with the diagnosis of a physical urticaria and were evaluated by using challenge testing directed toward the presenting diagnosis, yet included other stimuli based on history...
November 2014: Journal of Allergy and Clinical Immunology in Practice
Angeliki Giannelou, Qing Zhou, Daniel L Kastner
PURPOSE OF REVIEW: Next-generation sequencing is revolutionizing the molecular taxonomy of human disease. Recent studies of patients with unexplained autoinflammatory disorders reveal germline genetic mutations that target important regulators of innate immunity. RECENT FINDINGS: Whole-exome analyses of previously undiagnosed patients have catalyzed the recognition of two new disease genes. First, a phenotypic spectrum, including livedo racemosa, fever with early-onset stroke, polyarteritis nodosa, and Sneddon syndrome, is caused by loss-of-function mutations in cat eye syndrome chromosome region, candidate 1 (CECR1), encoding adenosine deaminase 2...
December 2014: Current Opinion in Allergy and Clinical Immunology
Anne K Ellis, Tarit Saha, Ramiro Arellano, Andrew Zajac, Darrin M Payne
Cold-induced urticaria (CIU) is a potentially life-threatening immunologic disorder characterized by swelling and edema of exposed tissue in response to a cold stimulus. We describe the successful management of a patient with a history of severe CIU who required coronary bypass and repair of an ascending aortic aneurysm using hypothermic circulatory arrest.
November 2013: Annals of Thoracic Surgery
Elana Fay Hochstadter, Moshe Ben-Shoshan
Cold-induced urticaria (CU) is a chronic physical urticaria that can be hard to diagnose and manage. Symptoms of CU can vary from mild localised urticaria, angio-oedema to anaphylaxis. CU may be induced by a wide range of cold triggers from aquatic activities to ingestions of cold substances. This exemplifies the importance of accurate diagnosis and management of patients with CU. We present three cases of CU that demonstrate the variability in triggers and clinical presentation.
July 8, 2013: BMJ Case Reports
Joseph Meyer, Alexander M Gorbach, Wei-Min Liu, Nevenka Medic, Michael Young, Celeste Nelson, Sarah Arceo, Avanti Desai, Dean D Metcalfe, Hirsh D Komarow
BACKGROUND: While a number of the consequences of mast cell degranulation within tissues have been documented including tissue-specific changes such as bronchospasm and the subsequent cellular infiltrate, there is little known about the immediate effects of mast cell degranulation on the associated vasculature, critical to understanding the evolution of mast cell dependent inflammation. OBJECTIVE: To characterize the microcirculatory events that follow mast cell degranulation...
2013: PloS One
Qing Zhou, Geun-Shik Lee, Jillian Brady, Shrimati Datta, Matilda Katan, Afzal Sheikh, Marta S Martins, Tom D Bunney, Brian H Santich, Susan Moir, Douglas B Kuhns, Debra A Long Priel, Amanda Ombrello, Deborah Stone, Michael J Ombrello, Javed Khan, Joshua D Milner, Daniel L Kastner, Ivona Aksentijevich
Whole-exome sequencing was performed in a family affected by dominantly inherited inflammatory disease characterized by recurrent blistering skin lesions, bronchiolitis, arthralgia, ocular inflammation, enterocolitis, absence of autoantibodies, and mild immunodeficiency. Exome data from three samples, including the affected father and daughter and unaffected mother, were filtered for the exclusion of reported variants, along with benign variants, as determined by PolyPhen-2. A total of eight transcripts were identified as possible candidate genes...
October 5, 2012: American Journal of Human Genetics
Joe C Furr, Mukta Panda
INTRODUCTION: Cryopyrin-associated periodic syndrome is a rare genetic disorder causing cold-induced urticaria, severe arthralgias, and (potentially) renal failure and hearing loss. Therapies that effectively control the symptoms and prevent the complications of this debilitating disorder are now available, making recognition of this disease important. CASE PRESENTATION: A 60-year-old Caucasian woman presented with complaints of rash and joint pains to a general medicine clinic...
February 20, 2012: Journal of Medical Case Reports
Michael J Ombrello, Elaine F Remmers, Guangping Sun, Alexandra F Freeman, Shrimati Datta, Parizad Torabi-Parizi, Naeha Subramanian, Tom D Bunney, Rhona W Baxendale, Marta S Martins, Neil Romberg, Hirsh Komarow, Ivona Aksentijevich, Hun Sik Kim, Jason Ho, Glenn Cruse, Mi-Yeon Jung, Alasdair M Gilfillan, Dean D Metcalfe, Celeste Nelson, Michelle O'Brien, Laura Wisch, Kelly Stone, Daniel C Douek, Chhavi Gandhi, Alan A Wanderer, Hane Lee, Stanley F Nelson, Kevin V Shianna, Elizabeth T Cirulli, David B Goldstein, Eric O Long, Susan Moir, Eric Meffre, Steven M Holland, Daniel L Kastner, Matilda Katan, Hal M Hoffman, Joshua D Milner
BACKGROUND: Mendelian analysis of disorders of immune regulation can provide insight into molecular pathways associated with host defense and immune tolerance. METHODS: We identified three families with a dominantly inherited complex of cold-induced urticaria, antibody deficiency, and susceptibility to infection and autoimmunity. Immunophenotyping methods included flow cytometry, analysis of serum immunoglobulins and autoantibodies, lymphocyte stimulation, and enzymatic assays...
January 26, 2012: New England Journal of Medicine
Nevenka Medic, Avanti Desai, Hirsh Komarow, Lauranell H Burch, Geethani Bandara, Michael A Beaven, Dean D Metcalfe, Alasdair M Gilfillan
Mast cells are considered the primary initiators of allergic diseases as a consequence of the release of multiple inflammatory mediators on activation. Although predominately activated through antigen-mediated aggregation of IgE-occupied-FcɛRI, they can also be induced to release mediators by other receptors and environmental stimuli. Based on studies conducted in the RBL 2H3 rodent mast cell line, the transient receptor potential melastatin 8 (TRPM8) cation channel has been implicated in the activation of mast cells in response to cold and, by inference, the development of urticaria...
November 2011: Cell Calcium
Anil Kurian, Jason K Lee, Peter Vadas
BACKGROUND: Schnitzler syndrome encompasses monoclonal gammopathy, urticaria, inflammation, recurrent fever, bone pain and arthralgia, with occasional lymphadenopathy and/or hepatosplenomegaly. It is a rare condition with approximately 100 cases reported in the literature. To our knowledge, this is the first reported case of cold-induced physical urticaria with Schnitzler syndrome. MAIN OBSERVATIONS: A 43-year-old woman presented to an allergy and immunology clinic with a 7 year history of chronic urticaria, angioedema with anaphylaxis, monoclonal gammopathy and bone pain...
December 31, 2010: Journal of Dermatological Case Reports
Nancy Habib, Nazanin Saedi, Christopher Zachary
No abstract text is available yet for this article.
November 2011: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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